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Lasers in Medical Science

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01.03.2007 | Original Article

Irradiation at 634 nm releases nitric oxide from human monocytes

verfasst von: Ann Lindgård, Lillemor Mattsson Hultén, Lennart Svensson, Bassam Soussi

Erschienen in: Lasers in Medical Science | Ausgabe 1/2007

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Abstract

Previous studies have shown that irradiation at 634 nm decreases the release of extracellular reactive oxygen species (ROS) without affecting viability in human monocytes. Here, we examined the effect of irradiation at 634 nm on the release of nitric oxide (NO), activation of inducible nitric oxide synthase (iNOS) and endothelial NOS (eNOS), and release of intracellular ROS. Chemiluminescence assays were used to measure NO release, intracellular ROS, and adenosine triphosphate levels (to assess cell viability). Levels of iNOS and eNOS mRNA were analyzed using PCR. Irradiation resulted in elevated levels of NO but had no effect on iNOS or eNOS. Irradiation also caused a decrease in levels of intracellular ROS and had no effect on cell viability. Our studies indicate that irradiation at 634 nm releases NO, possibly from a preformed store, and reduces the production of intracellular ROS without affecting cell viability. Irradiation at 634 nm may have a wide range of clinical applications, including a reduction in oxidative stress-mediated injury in the vasculature.

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Titel: Irradiation at 634 nm releases nitric oxide from human monocytes
verfasst von: Ann Lindgård
Lillemor Mattsson Hultén
Lennart Svensson
Bassam Soussi
Publikationsdatum: 01.03.2007
Verlag: Springer-Verlag
Erschienen in: Lasers in Medical Science / Ausgabe 1/2007
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-006-0419-5

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

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Irradiation at 634 nm releases nitric oxide from human monocytes

Abstract

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

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