Background
Methods
Patients
Evaluation of clinicopathological variables
Statistical analysis
Results
Effect of adjuvant chemotherapy on disease-free survival
Adjuvant chemotherapy (N = 150) | Surgery-only (N = 360) |
P-value | |||
---|---|---|---|---|---|
N
| % |
N
| % | ||
Age (years) | |||||
≤ 65 | 108 | 72.0 | 246 | 69.3 | 0.461 |
> 65 | 42 | 28.0 | 114 | 31.7 | |
Gender | 0.920 | ||||
Male | 95 | 63.3 | 225 | 62.5 | |
Female | 55 | 36.7 | 135 | 37.5 | |
BMI (kg/m2) | 0.990 | ||||
< 25 | 102 | 68.0 | 245 | 68.1 | |
≥ 25 | 48 | 32.0 | 115 | 31.9 | |
Type of resection | 0.060 | ||||
STG | 140 | 93.3 | 315 | 87.5 | |
TG | 10 | 6.7 | 45 | 12.5 | |
Reconstruction | 0.168 | ||||
BI | 70 | 46.7 | 174 | 48.3 | |
BII | 68 | 45.3 | 139 | 38.6 | |
Roux-en-Y | 12 | 8.0 | 47 | 13.1 | |
Tumor location | 0.416 | ||||
Upper | 9 | 6.0 | 20 | 5.6 | |
Middle | 44 | 29.3 | 128 | 35.6 | |
Lower | 97 | 64.7 | 212 | 58.9 | |
Gross type | 0.812 | ||||
Elevated | 30 | 20.0 | 77 | 21.4 | |
Non-elevated | 120 | 80.0 | 283 | 78.6 | |
Depth of invasion | 0.420 | ||||
Mucosa | 26 | 17.3 | 52 | 14.4 | |
Submucosa | 124 | 82.7 | 308 | 85.6 | |
No. of metastatic LN |
0.015
| ||||
One | 85 | 56.7 | 245 | 68.1 | |
Two | 65 | 43.3 | 115 | 31.9 | |
Lymphovascular invasion |
<0.001
| ||||
Positive | 91 | 60.7 | 150 | 41.7 | |
Negative | 59 | 39.3 | 210 | 58.3 | |
Histologic type | 0.656 | ||||
Differentiated | 23 | 12.5 | 161 | 87.5 | |
Undifferentiated | 28 | 14.1 | 171 | 85.9 |
Prevalence and predictive factors of tumor recurrence
Univariate analysis | Multivariate analysis | |||||
---|---|---|---|---|---|---|
HR | 95% CI |
P
| HR | 95% CI |
P
| |
Age | ||||||
≤ 65 | ||||||
> 65 | 2.625 | 1.384–4.981 |
0.003
| 2.541 | 1.336–4.831 |
0.004
|
Gender | ||||||
Female | ||||||
Male | 2.401 | 1.101–5.240 |
0.028
| 2.217 | 1.013–4.854 |
0.046
|
BMI (kg/m2) | ||||||
≥ 25 | ||||||
< 25 | 2.599 | 1.086–6.216 |
0.032
| 2.400 | 1.001–5.759 | 0.050 |
Type of resection | ||||||
Subtotal | ||||||
Total | 0.718 | 0.221–2.334 | 0.581 | |||
Tumor location | ||||||
Upper | ||||||
Middle | 0.871 | 0.193–3.932 | 0.857 | |||
Lower | 1.167 | 0.276–4.928 | 0.834 | |||
Gross type | ||||||
Non-elevated | ||||||
Elevated | 2.063 | 1.054–4.037 |
0.035
| 1.821 | 0.929–3.570 | 0.081 |
Depth of invasion | ||||||
Mucosa | ||||||
Submucosa | 3.464 | 0.834–14.394 | 0.087 | |||
No. of metastatic LN | ||||||
One | ||||||
Two | 1.194 | 0.623–2.288 | 0.594 | |||
No. of negative LN | 0.996 | 0.975–1.017 | 0.697 | |||
Lymphatic invasion | ||||||
Negative | ||||||
Positive | 1.800 | 0.939–3.454 | 0.077 | |||
Histologic type | ||||||
Undifferentiated | ||||||
Differentiated | 2.251 | 1.163–4.356 |
0.016
| 1.548 | 0.776–3.087 | 0.215 |
Adjuvant CTx | ||||||
No | ||||||
Yes | 0.919 | 0.455–1.859 | 0.815 | 0.952 | 0.467–1.937 | 0.891 |
Patterns of tumor recurrence
Recurrence | ||||
---|---|---|---|---|
Pattern | Total (N = 38) | Within 2 years (N = 18) | 2–5 years (N = 14) | After 5 years (N = 6) |
Remnant stomach | 7 (A: 2, R: 5) | 2 (R: 2) | 3 (A: 2, R:1) | 2 (R: 2) |
Peritoneal | 2 | 2 | 0 | 0 |
Hematogenous | 9 (H: 1, P: 1, B: 1) | 6 (H: 5, P: 1) | 1 (H: 1) | 2(H: 1, B: 1) |
Distant lymph node | 11 | 3 | 7 | 1 |
Mixed | 9 | 5 | 3 | 1 |