Erschienen in:
01.06.2005 | Brief Report
Isolation of vaccine-derived polioviruses in the Slovak Republic
verfasst von:
B. Černáková, Z. Sobotová, I. Rovný, Š. Bláhova, M. Roivainen, T. Hovi
Erschienen in:
European Journal of Clinical Microbiology & Infectious Diseases
|
Ausgabe 6/2005
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Excerpt
Environmental sampling is an important supplemental method for poliovirus surveillance in polio-free countries. Vaccine-derived polio viruses (VDPV), defined as Sabin vaccine viruses that show greater than 1% drift within the VP1 region of the genome, represent a major challenge to the eradication of polio [
1]. VDPVs may acquire the neurovirulence and, potentially, the transmission characteristics of wild polioviruses, possibly leading to polio outbreaks. In this communication we report the repeated isolation of VDPVs in Slovakia and note the implications with regard to vaccination in the Slovak Republic and the eradication of polio. …