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Erschienen in: Current Geriatrics Reports 3/2013

01.09.2013 | Infectious Diseases in the Elderly (SF Bradley, Section Editor)

Issues in the Diagnosis and Management of Urinary Tract Infections in the Older Adult

verfasst von: Lindsay E. Nicolle

Erschienen in: Current Geriatrics Reports | Ausgabe 3/2013

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Abstract

Urinary tract infection is a common problem of elderly populations. Clinical trials addressing urinary infection in the elderly frequently use nonstandardized diagnostic criteria, which compromises the validity of conclusions. Studies of prevention of infection in postmenopausal women in the community consistently report outcomes similar to observations in premenopausal women. Antimicrobial prophylaxis or self-treatment is effective, and cranberry products or probiotics are not beneficial. Critical evaluation of nursing home populations reports no association between nonspecific, nonlocalizing symptoms of any duration and bacteriuria. Optimal antimicrobial use for urinary infection, particularly for residents of long term care facilities, remains challenging. A high proportion of residents in some facilities receive prophylactic therapy to prevent urinary tract infections without evidence to support this practice. Evaluations of multifaceted antimicrobial stewardship programs to improve antimicrobial use in nursing homes report modest benefits.
Literatur
1.
Zurück zum Zitat Nicolle LE. Urinary tract infections in the elderly. Clin Geriat Med. 2009;25:423–36.CrossRef Nicolle LE. Urinary tract infections in the elderly. Clin Geriat Med. 2009;25:423–36.CrossRef
2.
Zurück zum Zitat Beveridge LA, Davey PG, Phillips G, McMurdo MET. Optimal management of urinary tract infections in older people. Clin Interv Aging. 2011;6:173–80.PubMedCrossRef Beveridge LA, Davey PG, Phillips G, McMurdo MET. Optimal management of urinary tract infections in older people. Clin Interv Aging. 2011;6:173–80.PubMedCrossRef
3.
Zurück zum Zitat Ariathianto Y. Asymptomatic bacteriuria. Prevalence in the elderly population. Aust Fam Physician. 2011;40:805–9.PubMed Ariathianto Y. Asymptomatic bacteriuria. Prevalence in the elderly population. Aust Fam Physician. 2011;40:805–9.PubMed
4.
Zurück zum Zitat Buhr GT, Genao L, White HK. Urinary tract infections in long-term care residents. Clin Geriatr Med. 2011;27:229–39.PubMedCrossRef Buhr GT, Genao L, White HK. Urinary tract infections in long-term care residents. Clin Geriatr Med. 2011;27:229–39.PubMedCrossRef
5.
Zurück zum Zitat Marques LPJ, Flores JT, Barros Jr O, Rodrigues GB, Mourao C, Moreira RMP. Epidemiological and clinical aspects of urinary tract infection in community-dwelling elderly women. Braz J Infect Dis. 2012;16:436–41.PubMedCrossRef Marques LPJ, Flores JT, Barros Jr O, Rodrigues GB, Mourao C, Moreira RMP. Epidemiological and clinical aspects of urinary tract infection in community-dwelling elderly women. Braz J Infect Dis. 2012;16:436–41.PubMedCrossRef
6.
Zurück zum Zitat • Caljouw MAA, den Elzen WPJ, Cools HJM, Gussekloo J. Predictive factors of urinary tract infections among the oldest in the general population. A population-based prospective follow-up study. BMC Med. 2011;9:57. This prospective population based study describes the frequency of urinary infection in a cohort of subjects over 85 years of age. Independent predictors of urinary infection in community subjects were functional impairment and prior urinary infection, similar to observations in long term care facility residents.PubMedCrossRef • Caljouw MAA, den Elzen WPJ, Cools HJM, Gussekloo J. Predictive factors of urinary tract infections among the oldest in the general population. A population-based prospective follow-up study. BMC Med. 2011;9:57. This prospective population based study describes the frequency of urinary infection in a cohort of subjects over 85 years of age. Independent predictors of urinary infection in community subjects were functional impairment and prior urinary infection, similar to observations in long term care facility residents.PubMedCrossRef
7.
Zurück zum Zitat Arinzon Z, Shabat S, Peisakh A, Berner Y. Clinical presentation of urinary tract infection (UTI) differs with aging in women. Arch Gerontol Geriatr. 2012;55:145–7.PubMedCrossRef Arinzon Z, Shabat S, Peisakh A, Berner Y. Clinical presentation of urinary tract infection (UTI) differs with aging in women. Arch Gerontol Geriatr. 2012;55:145–7.PubMedCrossRef
8.
Zurück zum Zitat Zhong YH, Fang Y, Zhou JZ, et al. Effectiveness and safety of patient-initiated single-dose versus continuous low-dose antibiotic prophylaxis for recurrent urinary tract infections in postmenopausal women: a randomized controlled study. J Int Med Res. 2011;39:2335–43.PubMedCrossRef Zhong YH, Fang Y, Zhou JZ, et al. Effectiveness and safety of patient-initiated single-dose versus continuous low-dose antibiotic prophylaxis for recurrent urinary tract infections in postmenopausal women: a randomized controlled study. J Int Med Res. 2011;39:2335–43.PubMedCrossRef
9.
Zurück zum Zitat Takahashi S, Hamasuna R, Yasuda M, et al. A randomized clinical trial to evaluate the preventive effect of cranberry juice (UR65) for patients with recurrent urinary tract infection. J Infect Chemother 2012; Sep 8. (Epub ahead of print). Takahashi S, Hamasuna R, Yasuda M, et al. A randomized clinical trial to evaluate the preventive effect of cranberry juice (UR65) for patients with recurrent urinary tract infection. J Infect Chemother 2012; Sep 8. (Epub ahead of print).
10.
Zurück zum Zitat •• Beerepoot MAJ, ter Riet G, Nys S, Stobberingh E, Geerlings SE. Lactobacilli vs antibiotics to prevent urinary tract infections. Arch Intern Med. 2012;172:704–12. For post-menopausal women with frequent recurrent urinary tract infection, trimethoprim/sulfamethoxazole prophylaxis was superior to oral probiotic capsules for prevention. This benefit was restricted to women with uncomplicated urinary tract infection.PubMedCrossRef •• Beerepoot MAJ, ter Riet G, Nys S, Stobberingh E, Geerlings SE. Lactobacilli vs antibiotics to prevent urinary tract infections. Arch Intern Med. 2012;172:704–12. For post-menopausal women with frequent recurrent urinary tract infection, trimethoprim/sulfamethoxazole prophylaxis was superior to oral probiotic capsules for prevention. This benefit was restricted to women with uncomplicated urinary tract infection.PubMedCrossRef
11.
Zurück zum Zitat Caterino JM, Ting SA, Sisbarro SG, et al. Age, nursing home residence, and presentation of urinary tract infection in U.S. emergency departments, 2001-2008. Acad Emerg Med. 2012;19:1173–80.PubMedCrossRef Caterino JM, Ting SA, Sisbarro SG, et al. Age, nursing home residence, and presentation of urinary tract infection in U.S. emergency departments, 2001-2008. Acad Emerg Med. 2012;19:1173–80.PubMedCrossRef
12.
Zurück zum Zitat •• Sundvall P-D, Ulleryd P, Gunnarsson RK. Urine culture doubtful in determining etiology of diffuse symptoms among elderly individuals: a cross-sectional study of 32 nursing homes. BMC Fam Pract. 2011;12:36. This study examined the correlation of bacteriuria with a wide range of nonspecific symptoms of varying duration among nursing home residents. No symptoms had prognostic value for identifying bacteriuria. It was concluded that obtaining urine cultures in these individuals was unhelpful for clinical management.PubMedCrossRef •• Sundvall P-D, Ulleryd P, Gunnarsson RK. Urine culture doubtful in determining etiology of diffuse symptoms among elderly individuals: a cross-sectional study of 32 nursing homes. BMC Fam Pract. 2011;12:36. This study examined the correlation of bacteriuria with a wide range of nonspecific symptoms of varying duration among nursing home residents. No symptoms had prognostic value for identifying bacteriuria. It was concluded that obtaining urine cultures in these individuals was unhelpful for clinical management.PubMedCrossRef
13.
Zurück zum Zitat •• Das R, Towle V, Van Ness PH, Juthani-Mehta M. Adverse outcomes in nursing home residents with increased episodes of observed bacteriuria. Infect Cont Hosp Epidemiol. 2011;32:84–6. An increasing number of episodes of bacteriuria with pyuria identified in female residents was associated with increased antimicrobial use and isolation of multiply drug resistant gram negative rods, but not with changes in mental status or hospitalization for urinary infection. The adverse events were those of inappropriate antimicrobial use rather than attributable to bacteriuria.CrossRef •• Das R, Towle V, Van Ness PH, Juthani-Mehta M. Adverse outcomes in nursing home residents with increased episodes of observed bacteriuria. Infect Cont Hosp Epidemiol. 2011;32:84–6. An increasing number of episodes of bacteriuria with pyuria identified in female residents was associated with increased antimicrobial use and isolation of multiply drug resistant gram negative rods, but not with changes in mental status or hospitalization for urinary infection. The adverse events were those of inappropriate antimicrobial use rather than attributable to bacteriuria.CrossRef
14.
Zurück zum Zitat Lin S-Y. A pilot study – fluid intake and bacteriuria in nursing home residents in southern Taiwan. Nursing Res. 2013;62:66–72.CrossRef Lin S-Y. A pilot study – fluid intake and bacteriuria in nursing home residents in southern Taiwan. Nursing Res. 2013;62:66–72.CrossRef
15.
Zurück zum Zitat • 15. Bianco L, Perrelli E, Towle V, et al. Pilot randomized controlled dosing study of cranberry capsules for reduction of bacteriuria plus pyuria in female nursing home residents. Jour Amer Ger Soc 60:1180-1181. This pilot study reported no decrease in bacteriuria in residents given any of three doses of cranberry capsules compared with placebo. • 15. Bianco L, Perrelli E, Towle V, et al. Pilot randomized controlled dosing study of cranberry capsules for reduction of bacteriuria plus pyuria in female nursing home residents. Jour Amer Ger Soc 60:1180-1181. This pilot study reported no decrease in bacteriuria in residents given any of three doses of cranberry capsules compared with placebo.
16.
Zurück zum Zitat Jonsson K, Claesson BEB, Hedelin H. Urine cultures from indwelling bladder catheters in nursing home patients: a point prevalence study in a Swedish county. Scand J Urol Nephrol. 2011;45:265–9.PubMedCrossRef Jonsson K, Claesson BEB, Hedelin H. Urine cultures from indwelling bladder catheters in nursing home patients: a point prevalence study in a Swedish county. Scand J Urol Nephrol. 2011;45:265–9.PubMedCrossRef
17.
Zurück zum Zitat Chung Y-C, Chen H-H, Yeh M-L. Vinegar for decreasing catheter-associated bacteriuria in long-term catheterized patients: a randomized controlled trial. Biol Res Nurs. 2012;14:294–301.PubMedCrossRef Chung Y-C, Chen H-H, Yeh M-L. Vinegar for decreasing catheter-associated bacteriuria in long-term catheterized patients: a randomized controlled trial. Biol Res Nurs. 2012;14:294–301.PubMedCrossRef
18.
Zurück zum Zitat Haasum Y, Fastbom J, Johnell K. Different patterns in use of antibiotics for lower urinary tract infection in institutionalized and home-dwelling elderly: a register-based study. Eur J Clin Pharmacol. 2013;69:665–71.PubMedCrossRef Haasum Y, Fastbom J, Johnell K. Different patterns in use of antibiotics for lower urinary tract infection in institutionalized and home-dwelling elderly: a register-based study. Eur J Clin Pharmacol. 2013;69:665–71.PubMedCrossRef
19.
Zurück zum Zitat Fagan M, Maehlen M, Lindbaek M, Berild D. Antibiotic prescribing in nursing homes in an area with low prevalence of antibiotic resistance: Compliance with national guidelines. Scand J Prim Health Care. 2012;30:10–5.PubMedCrossRef Fagan M, Maehlen M, Lindbaek M, Berild D. Antibiotic prescribing in nursing homes in an area with low prevalence of antibiotic resistance: Compliance with national guidelines. Scand J Prim Health Care. 2012;30:10–5.PubMedCrossRef
20.
Zurück zum Zitat • Bergman J, Schjott J, Blix HS. Prevention of urinary tract infections in nursing homes: lack of evidence-based prescription? BMC Geriatr. 2011;11:69. A point prevalence survey in Norwegian nursing homes reported that 18 % of residents were receiving prophylaxis for urinary infection, despite there being no evidence to support prophylactic use in this setting.PubMedCrossRef • Bergman J, Schjott J, Blix HS. Prevention of urinary tract infections in nursing homes: lack of evidence-based prescription? BMC Geriatr. 2011;11:69. A point prevalence survey in Norwegian nursing homes reported that 18 % of residents were receiving prophylaxis for urinary infection, despite there being no evidence to support prophylactic use in this setting.PubMedCrossRef
21.
Zurück zum Zitat Phillips CD, Adepoju O, Stone N, et al. Asymptomatic bacteriuria, antibiotic use, and suspected urinary tract infections in four nursing homes. BMC Geriatr. 2012;12:73.PubMedCrossRef Phillips CD, Adepoju O, Stone N, et al. Asymptomatic bacteriuria, antibiotic use, and suspected urinary tract infections in four nursing homes. BMC Geriatr. 2012;12:73.PubMedCrossRef
22.
Zurück zum Zitat •• Rummukainen J-L, Jakobsson A, Matsinen M, et al. Reduction in inappropriate prevention of urinary tract infections in long-term care facilities. Am J Infect Control. 2012;40:711–4. The authors developed and tested a multifaceted intervention to decrease the use of prophylactic antimicrobials for urinary infection in Finnish long term care facilities. There was a significant decrease in the proportion of residents receiving antimicrobial prophylaxis for urinary infection, which was attributed to the intervention program.PubMedCrossRef •• Rummukainen J-L, Jakobsson A, Matsinen M, et al. Reduction in inappropriate prevention of urinary tract infections in long-term care facilities. Am J Infect Control. 2012;40:711–4. The authors developed and tested a multifaceted intervention to decrease the use of prophylactic antimicrobials for urinary infection in Finnish long term care facilities. There was a significant decrease in the proportion of residents receiving antimicrobial prophylaxis for urinary infection, which was attributed to the intervention program.PubMedCrossRef
23.
Zurück zum Zitat • Pettersson E, Vernby A, Holstad S, Lundborg CS. Can a multifaceted educational intervention targeting both nurses and physicians change the prescribing of antibiotics to nursing home residents? A cluster randomized controlled trial. J Antimicrob Chemother. 2011;66:2659–66. The primary outcome of fluoroquinolone use for urinary infection decreased for both intervention and control homes, but there was no difference post-intervention between the two. Overall antimicrobial use and a “wait and see” approach for infection management were significantly improved in intervention homes.PubMedCrossRef • Pettersson E, Vernby A, Holstad S, Lundborg CS. Can a multifaceted educational intervention targeting both nurses and physicians change the prescribing of antibiotics to nursing home residents? A cluster randomized controlled trial. J Antimicrob Chemother. 2011;66:2659–66. The primary outcome of fluoroquinolone use for urinary infection decreased for both intervention and control homes, but there was no difference post-intervention between the two. Overall antimicrobial use and a “wait and see” approach for infection management were significantly improved in intervention homes.PubMedCrossRef
24.
Zurück zum Zitat Smithson A, Chico C, Ramos J, et al. Prevalence and risk factors for quinolone resistance among Escherichia coli strains isolated from males with community febrile urinary tract infection. Eur J Clin Microbiol Infect Dis. 2012;31:423–30.PubMedCrossRef Smithson A, Chico C, Ramos J, et al. Prevalence and risk factors for quinolone resistance among Escherichia coli strains isolated from males with community febrile urinary tract infection. Eur J Clin Microbiol Infect Dis. 2012;31:423–30.PubMedCrossRef
25.
Zurück zum Zitat Tinelli M, Cataldo MA, Mantengoli E, et al. Epidemiology and genetic characteristics of extended-spectrum β-lactamase-producing Gram-negative bacteria causing urinary tract infections in long-term care facilities. J Antimicrob Chemother. 2012;67:2982–7.PubMedCrossRef Tinelli M, Cataldo MA, Mantengoli E, et al. Epidemiology and genetic characteristics of extended-spectrum β-lactamase-producing Gram-negative bacteria causing urinary tract infections in long-term care facilities. J Antimicrob Chemother. 2012;67:2982–7.PubMedCrossRef
26.
Zurück zum Zitat Neuner EA, Sekeres J, Hall GS, van Duin D. Experience with fosfomycin for treatment of urinary tract infections due to multidrug-resistant organisms. Antimicrob Agents Chemother. 2012;56:5744–8.PubMedCrossRef Neuner EA, Sekeres J, Hall GS, van Duin D. Experience with fosfomycin for treatment of urinary tract infections due to multidrug-resistant organisms. Antimicrob Agents Chemother. 2012;56:5744–8.PubMedCrossRef
27.
Zurück zum Zitat Alexander BT, Marschall J, Tibbetts RJ, et al. Treatment and clinical outcomes of urinary tract infections caused by KPC-producing Enterobacteriaceae in a retrospective cohort. Clin Ther. 2012;34:1314–23.PubMedCrossRef Alexander BT, Marschall J, Tibbetts RJ, et al. Treatment and clinical outcomes of urinary tract infections caused by KPC-producing Enterobacteriaceae in a retrospective cohort. Clin Ther. 2012;34:1314–23.PubMedCrossRef
28.
Zurück zum Zitat • Tasbakan MI, Pullukcu H, Sipahi OR, Yamazhan T, Ulusoy S. Nitrofurantoin in the treatment of extended-spectrum β-lactamase producing Escherichia coli-related lower urinary tract infection. Int J Antimicrob Agents. 2012;40:554–6. In patients with ESBL producing organisms sensitive to nitrofurantoin isolated from urinary culture, 70 % were cured with nitrofurantoin therapy. Most of these patients had complicated lower urinary tract infection.PubMedCrossRef • Tasbakan MI, Pullukcu H, Sipahi OR, Yamazhan T, Ulusoy S. Nitrofurantoin in the treatment of extended-spectrum β-lactamase producing Escherichia coli-related lower urinary tract infection. Int J Antimicrob Agents. 2012;40:554–6. In patients with ESBL producing organisms sensitive to nitrofurantoin isolated from urinary culture, 70 % were cured with nitrofurantoin therapy. Most of these patients had complicated lower urinary tract infection.PubMedCrossRef
Metadaten
Titel
Issues in the Diagnosis and Management of Urinary Tract Infections in the Older Adult
verfasst von
Lindsay E. Nicolle
Publikationsdatum
01.09.2013
Verlag
Springer US
Erschienen in
Current Geriatrics Reports / Ausgabe 3/2013
Elektronische ISSN: 2196-7865
DOI
https://doi.org/10.1007/s13670-013-0046-5

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