Ausgabe Sonderheft 1/2014
Melanoma Bridge 2013: Poster and Oral Presentations
Inhalt (26 Artikel)
Revealing cancer initiating cells in metastatic melanomas by harnessing the host′s anti tumor humoral immune mechanisms
Beatrix Kotlan, Gabriella Liszkay, Gyorgy Naszados, Judit Olasz, Szabolcs Horvath, Klara Eles, Miri Blank, Yehuda Shoenfeld, Laszlo Gobor, Laszlo Toth, Orsolya Csuka, Maria Godeny, Miklos Kasler, Francesco M Marincola
Activation of the ErbB3-AKT axis promotes melanoma cell survival and proliferation in response to RAF/MEK inhibition
Luigi Fattore, Emanuele Marra, Maria Elena Pisanu, Alessia Noto, Claudia De Vitis, Francesca Belleudi, Luigi Aurisicchio, Rita Mancini, Maria Rosaria Torrisi, Paolo Antonio Ascierto, Gennaro Ciliberto
Assessment of germline and somatic alterations in main candidate genes among patients with multiple primary melanoma
Maria Colombino, Maria Cristina Sini, Amelia Lissia, Antonio Cossu, Vincenzo De Giorgi, Daniela Massi, Ignazio Stanganelli, Corrado Rubino, Antonella Manca, Grazia Palomba, Gerardo Botti, Corrado Caracò, Nicola Mozzillo, Paolo Antonio Ascierto, Giuseppe Palmieri
Regulation of melanoma initiating cells by Hedgehog signaling and SOX2
Roberta Santini, Silvia Pandolfi, Valentina Montagnani, Silvia Pietrobono, Nicola Pimpinelli, Lorenzo Borgognoni, Barbara Stecca
Efficacy of radiotherapy in patients on progression after treatment with ipilimumab 3 mg/kg
Antonio M Grimaldi, Ester Simeone, Diana Giannarelli, Paolo Muto, Sara Falivene, Fabio Sandomenico, Antonella Petrillo, Marcello Curvietto, Assunta Esposito, Miriam Paone, Marco Palla, Corrado Caracò, Gennaro Ciliberto, Nicola Mozzillo, Paolo A Ascierto
Updated results and correlative FDG-PET analysis of a phase IB study of vemurafenib and cobimetinib (MEK inhibitor [GDC-0973]), in advanced BRAF V600 - mutated melanoma (BRIM7)
Igor Puzanov, Grant McArthur, Rene Gonzalez, Anna Pavlick, Omid Hamid, Thomas F Gajewski, Ming Yin, Jill Fredrickson, Nicholas Choong, Antoni Ribas
Peripheral and tumor immune correlates in patients with advanced melanoma treated with nivolumab (anti-PD-1, BMS-936558, ONO-4538) monotherapy or in combination with ipilimumab
Michael A Postow, Diana M Cardona, Janis M Taube, Robert A Anders, Clive R Taylor, Jedd D Wolchok, Margaret K Callahan, Michael A Curran, Alexander M Lesokhin, Joseph F Grosso, Christine E Horak, John Cogswell, Jason S Simon, Ashok K Gupta, Mario Sznol
Ipilimumab treatment results in an early decrease in the frequency of circulating granulocytic myeloid derived suppressor cells as well as their arginase 1 production
Giusy Gentilcore, Coaña Pico de Yago, Isabel Poschke, Yumeng Mao, Maria Nyström, Johan Hansson, Giuseppe V Masucci, Rolf Kiessling
Harnessing host innate immunity may combat acquired resistance to BRAFi
Thomas Tan, Pradeepa Pangigadde, Francesco Sabbatino, Elvira Favoino, Laura Orgiano, Soldano Ferrone, Ennio Carbone, Francesco Colucci
Regulated intratumoral expression of IL-12 as a basis for combination therapy in melanoma
John J Nemunaitis, Gerald P Linette, Omid Hamid, Sanjiv S Agarwala, Alexander Starodub, Lei Sun, Francois Lebel, John A Barrett, Jonathan Lewis
Biomarker analysis of on-treatment and at progression biopsies from BRIM7 - a phase 1B trial of combined vemurafenib and cobimetinib treatment in BRAF V600 mutated melanoma
Yibing Yan, Grant McArthur, Omid Hamid, Igor Puzanov, Rene Gonzalez, Thomas Gajewski, Yulei Wang, Matthew Wongchenko, Nicholas Choong, Antoni Ribas
Systems biology analysis of immune signaling in peripheral blood mononuclear cells (PBMC) of melanoma patients receiving ipilimumab; basis for response biomarker identification
Drew Hotson, Ryan Alvarado, Andy Conroy, Santosh Putta, Ester Simeone, Assunta Esposito, Mariaelena Capone, Gabriele Madonna, Antonio M Grimaldi, David B Rosen, Spencer Liang, Alessandra Cesano, Carmela Cacciapuoti, Paolo A Ascierto, Rachael E Hawtin
Long-term response after electrochemotherapy in patients with relapsed or refractory cutaneous melanoma
Nicola Mozzillo, Corrado Caracò, Ugo Marone, Ester Simeone, Stefano Mori, Lucia Benedetto, Gianluca Di Monta, Maria Luisa Di Cecilia, Massimiliano Di Marzo, Gerardo Botti, Paolo Antonio Ascierto
A novel approach to target metastases of melanoma cells in an organ-selective manner
Saurav Roy Choudhury, Jennifer Rahn, Xiaoguang Hao, Liane Babes, Paul Kubes, Stephen M Robbins, Donna L Senger
UV exposure and melanoma prognostic factors : results from Clinical National Melanoma Registry (CNMR)
Maurizio Montella, Sara Gandini, Carlo Riccardo Rossi, Alessandro Testori, Giuseppe Mastrangelo, Diego Serraino, Mario Budroni, Anna Crispo, Antonio Maria Grimaldi, Paolo Antonio Ascierto
Psychological features in lower risk melanoma: an analysis on 204 patients
Ribero Simone, Bassino Stefania, Castelli Lorys, Grassi Marcella, Caliendo Virginia, Lauro Danilo, Balagna Elena Maira, Giaretti Marta, Leombruni Paolo, Torta Riccardo, Macripo Giuseppe
Phase Ib/II, open-label, dose-escalation study of LGX818, an oral selective BRAF inhibitor, in combination with MEK162, an oral MEK1/2 inhibitor, in patients with BRAF V600-dependent advanced solid tumors: preliminary results
Richard Kefford, Ryan J Sullivan, Wilson H Miller Jr, Elena M Elez, Daniel Tan, Kevin B Kim, Georgina V Long, Keith T Flaherty, David Tai, Simone Stutvoet, Heiko Maacke, Matt Whiley, Laure Moutouh-de Parseval, Josep Tabernero
Enrichment of KIR+CD57+ highly cytotoxic NK cells in sentinel lymph nodes of melanoma patients
Talib Hassan Ali, Simona Pisanti, Elena Ciaglia, Roberta Mortarini, Andrea Anichini, Mario Santinami, Elio Gulletta, Caterina Ietto, Mario Galgani, Cinzia Garofalo, Giuseppe Matarese, Maurizio Bifulco, Soldano Ferrone, Francesco Colucci, Alessandro Moretta, Klas Kärre, Ennio Carbone
MISIPI study: Melanoma ImmunoScore evaluation in patients treated with IPIlimumab
Carlo Bifulco, Marilena Capone, Zip Feng, Gabriele Madonna, Ester Simeone, Marcello Curvietto, Nicola Mozzillo, Gennaro Ciliberto, Gerardo Botti, Bernard A Fox, Paolo A Ascierto
hMENA splicing program impacts the clinical outcome of early stage lung cancer patients. How and why?
Paolo Visca, Sheila Spada, Francesca Di Modugno, Emilio Bria, Isabella Sperduti, Barbara Antoniani, Gabriele Alessandrini, Belinda Palermo, Vienna Ludovini, Lucio Crinò, Francesco Facciolo, Michele Milella, Marcella Mottolese, Paola Nisticò
Natural immunomodulator preimplantation factor PIF affected cancer growth in malignant melanomas
Beatrix Kotlan, Gyorgy Naszados, József Továri, János F László, Maria Godeny, Eytan R Barnea
Combination therapy with ipilimumab and electrochemotherapy: preliminary efficacy results and correlation with immunological parameters
Ester Simeone, Lucia Benedetto, Giusy Gentilcore, Marilena Capone, Corrado Caracò, Gianluca Di Monta, Ugo Marone, Marialuisa Di Cecilia, Antonio Maria Grimaldi, Stefano Mori, Nicola Mozzillo, Paolo A Ascierto
In vivo targeting of cutaneous melanoma using an MSH-engineered human protein cage bearing fluorophore and MRI tracers
Luca Vannucci, Elisabetta Falvo, Cristina Maria Failla, Miriam Carbo, Manuela Fornara, Rossella Canese, Serena Cecchetti, Lenka Rajsiglova, Dmitry Stakheev, Jiri Krizan, Alberto Boffi, Giulia Carpinelli, Veronica Morea, Pierpaolo Ceci
Barasertib: a novel approach for the treatment of metastatic melanoma
Amalia Azzariti, Letizia Porcelli, Anna Elisa Quatrale, Letizia Sidella, RM Iacobazzi, Gabriella Guida, Immacolata Maida, Tiziana Cocco, Anna Ferretta, Sabino Strippoli, Stefania Giuda, Stefani Tommasi, Angelo Paradiso, Michele Guida
Overall survival of patients with chemotherapy-naive advanced melanoma treated with ipilimumab 3 mg/kg in clinical trials
Reinhard Dummer, Dirk Schadendorf, Paolo A Ascierto, James Larkin, Celeste Lebbé, Axel Hauschild
The mitochondrial master regulator gene PGC1alpha in novel sporadic melanoma cell lines: correlations with BRAF mutational status
Gabriella Guida, Immacolata Maida, Anna Ferretta, Tiziana Cocco, Stefania Guida, Paola Zanna, Rossella Labarile, Letizia Porcelli, Amalia Azzariti, Stefania Tommasi, Anna Albano, Sabino Strippoli, Mari C Turpin Sevilla, Raffaele Filotico, Michele Guida