Journal of Translational Medicine

Endoplasmic reticulum stress mediates the myeloid-derived immune suppression associated with cancer and infectious disease

Xiaoli Lou, Deyong Gao, Liyuan Yang, Yue Wang, Yanqiang Hou

Angiotensin-(1–7) ameliorates sepsis-induced cardiomyopathy by alleviating inflammatory response and mitochondrial damage through the NF-κB and MAPK pathways

Xin-Sen Chen, Jing-Rui Cui, Xiang-Long Meng, Shu-Hang Wang, Wei Wei, Yu-Lei Gao, Song-Tao Shou, Yan-Cun Liu, Yan-Fen Chai

Gene’s expression underpinning the divergent predictive value of [18F]F-fluorodeoxyglucose and prostate-specific membrane antigen positron emission tomography in primary prostate cancer: a bioinformatic and experimental study

Matteo Bauckneht, Cecilia Marini, Vanessa Cossu, Cristina Campi, Mattia Riondato, Silvia Bruno, Anna Maria Orengo, Francesca Vitale, Sonia Carta, Silvia Chiola, Sabrina Chiesa, Alberto Miceli, Francesca D’Amico, Giuseppe Fornarini, Carlo Terrone, Michele Piana, Silvia Morbelli, Alessio Signori, Paola Barboro, Gianmario Sambuceti

Computed tomography-detected extramural venous invasion-related gene signature: a potential negative biomarker of immune checkpoint inhibitor treatment in patients with gastric cancer

Hao Yang, Xinyi Gou, Caizhen Feng, Yinli Zhang, Fan Chai, Nan Hong, Yingjiang Ye, Yi Wang, Bo Gao, Jin Cheng

PHF5A facilitates the development and progression of gastric cancer through SKP2-mediated stabilization of FOS

Zhandong Zhang, Liangqun Peng, Wei Yang, Baodong Li, Yawei Hua, Suxia Luo

Splicing factor-mediated regulation patterns reveals biological characteristics and aid in predicting prognosis in acute myeloid leukemia

Fang-Min Zhong, Fang-Yi Yao, Jing Liu, Mei-Yong Li, Jun-Yao Jiang, Ying Cheng, Shuai Xu, Shu-Qi Li, Nan Zhang, Bo Huang, Xiao-Zhong Wang

Aa-Z2 triggers ROS-induced apoptosis of osteosarcoma by targeting PDK-1

Yixin Liu, Wenyan She, Yi Li, Miao Wang, Yin Liu, Biao Ning, Tianzi Xu, Tianhe Huang, Yongchang Wei

D-Mannose prevents bone loss under weightlessness

Ranli Gu, Hao Liu, Menglong Hu, Yuan Zhu, Xuenan Liu, Feilong Wang, Likun Wu, Danyang Song, Yunsong Liu

Papillary thyroid cancer organoids harboring BRAFV600E mutation reveal potentially beneficial effects of BRAF inhibitor-based combination therapies

Dong Chen, Xi Su, Lizhang Zhu, Hao Jia, Bin Han, Haibo Chen, Qingzhuang Liang, Chenchen Hu, Hao Yang, Lisa Liu, Peng Li, Wei Wei, Yongsheng Zhao

Association between radiotherapy and risk of second primary malignancies in patients with resectable lung cancer: a population-based study

Bolun Zhou, Ruochuan Zang, Peng Song, Moyan Zhang, Fenglong Bie, Guangyu Bai, Yuan Li, Qilin Huai, Yuning Han, Shugeng Gao

A two-stage genome-wide association study identifies novel germline genetic variations in CACNA2D3 associated with radiotherapy response in nasopharyngeal carcinoma

Lu-Lu Yu, Bi-Wen Hu, Han-Xue Huang, Bing Yu, Qi Xiao, Qiao-Li Lv, Chen-Hui Luo, Cheng-Xian Guo, Jin-Gao Li, Xiao-Xue Xie, Ji-Ye Yin

Metabolomics to identify fingerprints of carotid atherosclerosis in nonobese metabolic dysfunction-associated fatty liver disease

Congxiang Shao, Lishu Xu, Pingguang Lei, Wei Wang, Shiting Feng, Junzhao Ye, Bihui Zhong

In-silico design and evaluation of an epitope-based serotype-independent promising vaccine candidate for highly cross-reactive regions of pneumococcal surface protein A

Elnaz Afshari, Reza Ahangari Cohan, Fattah Sotoodehnejadnematalahi, Seyed Fazlollah Mousavi

β-glucan protects against necrotizing enterocolitis in mice by inhibiting intestinal inflammation, improving the gut barrier, and modulating gut microbiota

Xingdao Zhang, Yuni Zhang, Yu He, Xingwang Zhu, Qing Ai, Yuan Shi

Multi-omics characterization of a scoring system to quantify hypoxia patterns in patients with head and neck squamous cell carcinoma

Cong Peng, Huiping Ye, Zhengyang li, Xiaofeng Duan, Wen Yang, Zhuguang Yi

GSDMD-mediated pyroptosis dominantly promotes left ventricular remodeling and dysfunction in post-myocardial infarction: a comparison across modes of programmed cell death and mitochondrial involvement

Chanon Piamsiri, Chayodom Maneechote, Kewarin Jinawong, Busarin Arunsak, Titikorn Chunchai, Wichwara Nawara, Siriporn C Chattipakorn, Nipon Chattipakorn

Concept and application of the probability of pharmacological success (PoPS) as a decision tool in drug development: a position paper

Chao Chen, Xuan Zhou, Silvia Maria Lavezzi, Usman Arshad, Raman Sharma

AFAP1L1 promotes gastric cancer progression by interacting with VAV2 to facilitate CDC42-mediated activation of ITGA5 signaling pathway

Bo Sun, Bai Ding, Yu Chen, Chuang Peng, Xu Chen

Molecular imaging of HER2 expression in breast cancer patients using a novel peptide-based tracer 99mTc-HP-Ark2: a pilot study

Jiyun Shi, Shuaifan Du, Rongxi Wang, Hannan Gao, Qi Luo, Guozhu Hou, Yidong Zhou, Zhaohui Zhu, Fan Wang

A machine learning framework develops a DNA replication stress model for predicting clinical outcomes and therapeutic vulnerability in primary prostate cancer

Rong-Hua Huang, Ying-Kai Hong, Heng Du, Wei-Qi Ke, Bing-Biao Lin, Ya-Lan Li

Plasma GAS6 predicts mortality risk in acute heart failure patients: insights from the DRAGON-HF trial

Teng Ma, Rongrong Huang, Yanhua Xu, Yangbo Lv, Yifan Liu, Xin Pan, Jia Dong, Di Gao, Zeyu Wang, Fenglei Zhang, Chunxi Yan, Sang-Bing Ong, Yang Su, Dachun Xu

CircNDC80 promotes glioblastoma multiforme tumorigenesis via the miR-139-5p/ECE1 pathway

Yuhang Wang, Binbin Wang, Fengqi Zhou, Kun Lv, Xiupeng Xu, Wenping Cao

A drug screening to identify novel combinatorial strategies for boosting cancer immunotherapy efficacy

Zongliang Zhang, Guoqing Wang, Kunhong Zhong, Yongdong Chen, Nian Yang, Qizhong Lu, Boyang Yuan, Zeng Wang, Hexian Li, Liping Guo, Ruyuan Zhang, Zhiguo Wu, Meijun Zheng, Shasha Zhao, Xin Tang, Bin Shao, Aiping Tong

Alamandine/MrgD axis prevents TGF-β1-mediated fibroblast activation via regulation of aerobic glycolysis and mitophagy

Wei Wang, Yue Zhang, Wenhui Huang, Yafei Yuan, Qiaohui Hong, Zhanzhan Xie, Lijuan Li, Yixin Chen, Xu Li, Ying Meng

Soluble PD-L1: a potential dynamic predictive biomarker for immunotherapy in patients with proficient mismatch repair colorectal cancer

Yinjun He, Xiang Zhang, Ming Zhu, Wenguang He, Hanju Hua, Feng Ye, Xile Zhou, Nan Chen, Yandong Li, Weixiang Zhong, Guosheng Wu, Hui Cai, Weiqin Jiang

M2 tumor-associated macrophage mediates the maintenance of stemness to promote cisplatin resistance by secreting TGF-β1 in esophageal squamous cell carcinoma

Kaige Yang, Yufang Xie, Lele Xue, Fanping Li, Chenghua Luo, Weihua Liang, Haijun Zhang, Ya Li, Yilin Ren, Mengmeng Zhao, Weinan Wang, Jia Liu, Xihua Shen, Wenhu Zhou, Jing Fei, Weigang Chen, Wenyi Gu, Lianghai Wang, Feng Li, Jianming Hu

Association of mitochondrial homeostasis and dynamic balance with malignant biological behaviors of gastrointestinal cancer

Ao-ran Liu, Zhi Lv, Zi-wei Yan, Xiao-yang Wu, Li-rong Yan, Li-ping Sun, Yuan Yuan, Qian Xu

EREG is the core onco-immunological biomarker of cuproptosis and mediates the cross-talk between VEGF and CD99 signaling in glioblastoma

Yujie Zhou, Dongdong Xiao, Xiaobing Jiang, Chuansheng Nie

Supplementation with medium-chain fatty acids increases body weight loss during very low-calorie ketogenic diet: a retrospective analysis in a real-life setting

Claudia Vetrani, Ludovica Verde, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri, Luigi Barrea

Transcriptomic analyses of treatment-naïve pediatric ulcerative colitis patients and exploration of underlying disease pathogenesis

Xiaoli Pang, Hongxiao Song, Xiaolu Li, Fengchao Xu, Bingxun Lei, Fei Wang, Jing Xu, Lingli Qi, Libo Wang, Guangyun Tan

Unmasking the biological function and regulatory mechanism of NOC2L: a novel inhibitor of histone acetyltransferase

Siyi Lu, Zhaoyu Chen, Zhenzhen Liu, Zhentao Liu

FASN multi-omic characterization reveals metabolic heterogeneity in pancreatic and prostate adenocarcinoma

Ugo Chianese, Chiara Papulino, Ahmad Ali, Fortunato Ciardiello, Salvatore Cappabianca, Lucia Altucci, Vincenzo Carafa, Rosaria Benedetti

The persistent viral infections in the development and severity of myalgic encephalomyelitis/chronic fatigue syndrome

Santa Rasa-Dzelzkaleja, Angelika Krumina, Svetlana Capenko, Zaiga Nora-Krukle, Sabine Gravelsina, Anda Vilmane, Lauma Ievina, Yehuda Shoenfeld, Modra Murovska

Tanshinone IIA ameliorates Aβ transendothelial transportation through SIRT1-mediated endoplasmic reticulum stress

Can Wan, Xiao-Qi Liu, Mei Chen, Hui-Han Ma, Guang-Liang Wu, Li-Jun Qiao, Ye-Feng Cai, Shi-Jie Zhang

Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging

Wei Wan, Lieliang Zhang, Yue Lin, Xiuqing Rao, Xifeng Wang, Fuzhou Hua, Jun Ying

Good practice in medicine and biology: scientific integrity needs global bioethics

Henri-Corto Stoeklé, Achille Ivasilevitch, Christian Hervé

The epigenetic factor CHD4 contributes to metastasis by regulating the EZH2/β-catenin axis and acts as a therapeutic target in ovarian cancer

Jieyu Wang, Fangfang Zhong, Jun Li, Huiran Yue, Wenzhi Li, Xin Lu

Hyperuricemia as an effect modifier of the association between metabolic phenotypes and nonalcoholic fatty liver disease in Chinese population

Jun Zheng, Xuerui Li, Yuan Zhang, Yuyang Miao, Qiang Zhang

Alterations of plasma exosomal proteins and motabolies are associated with the progression of castration-resistant prostate cancer

Pengyu Liu, Wenxuan Wang, Fei Wang, Jiaqi Fan, Jinan Guo, Tao Wu, Dongliang Lu, Qingchun Zhou, Zhuohao Liu, Yuliang Wang, Zhiqun Shang, Franky Leung Chan, Wei Yang, Xin Li, Shan-Chao Zhao, Qingyou Zheng, Fei Wang, Dinglan Wu

Panomics reveals patient individuality as the major driver of colorectal cancer progression

Friederike Praus, Axel Künstner, Thorben Sauer, Michael Kohl, Katharina Kern, Steffen Deichmann, Ákos Végvári, Tobias Keck, Hauke Busch, Jens K. Habermann, Timo Gemoll

An artificial intelligence model for the pathological diagnosis of invasion depth and histologic grade in bladder cancer

Jiexin Pan, Guibin Hong, Hong Zeng, Chengxiao Liao, Huarun Li, Yuhui Yao, Qinghua Gan, Yun Wang, Shaoxu Wu, Tianxin Lin

CCL3 secreted by hepatocytes promotes the metastasis of intrahepatic cholangiocarcinoma by VIRMA-mediated N6-methyladenosine (m6A) modification

Shurui Zhou, Kege Yang, Shaojie Chen, Guoda Lian, Yuzhou Huang, Hanming Yao, Yue Zhao, Kaihong Huang, Dong Yin, Haoming Lin, Yaqing Li

Radiogenomic analysis of prediction HER2 status in breast cancer by linking ultrasound radiomic feature module with biological functions

Hao Cui, Yue Sun, Dantong Zhao, Xudong Zhang, Hanqing Kong, Nana Hu, Panting Wang, Xiaoxuan Zuo, Wei Fan, Yuan Yao, Baiyang Fu, Jiawei Tian, Meixin Wu, Yue Gao, Shangwei Ning, Lei Zhang

Low expression of the dynamic network markers FOS/JUN in pre-deteriorated epithelial cells is associated with the progression of colorectal adenoma to carcinoma

Xiaoqi Huang, Chongyin Han, Jiayuan Zhong, Jiaqi Hu, Yabin Jin, Qinqin Zhang, Wei Luo, Rui Liu, Fei Ling

A multi-omic analysis reveals the esophageal dysbiosis as the predominant trait of eosinophilic esophagitis

Luca Massimino, Alberto Barchi, Francesco Vito Mandarino, Salvatore Spanò, Luigi Antonio Lamparelli, Edoardo Vespa, Sandro Passaretti, Laurent Peyrin-Biroulet, Edoardo Vincenzo Savarino, Vipul Jairath, Federica Ungaro, Silvio Danese

Lipolysis and gestational diabetes mellitus onset: a case-cohort genome-wide association study in Chinese

Miao Zhang, Qing Li, Kai-Lin Wang, Yao Dong, Yu-Tong Mu, Yan-Min Cao, Jin Liu, Zi-Heng Li, Hui-Lu Cui, Hai-Yan Liu, An-Qun Hu, Ying-Jie Zheng

DeepMPF: deep learning framework for predicting drug–target interactions based on multi-modal representation with meta-path semantic analysis

Zhong-Hao Ren, Zhu-Hong You, Quan Zou, Chang-Qing Yu, Yan-Fang Ma, Yong-Jian Guan, Hai-Ru You, Xin-Fei Wang, Jie Pan

Correction: Clinical validation of full HR-HPV genotyping HPV Selfy assay according to the international guidelines for HPV test requirements for cervical cancer screening on clinician-collected and self-collected samples

Alice Avian, Nicolò Clemente, Elisabetta Mauro, Erica Isidoro, Michela Di Napoli, Sandra Dudine, Anna Del Fabro, Stefano Morini, Tiziana Perin, Fabiola Giudici, Tamara Cammisuli, Nicola Foschi, Marco Mocenigo, Michele Montrone, Chiara Modena, Martina Polenghi, Luca Puzzi, Vjekoslav Tomaic, Giulio Valenti, Riccardo Sola, Shivani Zanolla, Enea Vogrig, Elisabetta Riva, Silvia Angeletti, Massimo Ciccozzi, Santina Castriciano, Maria Pachetti, Matteo Petti, Sandro Centonze, Daniela Gerin, Lawrence Banks, Bruna Marini, Vincenzo Canzonieri, Francesco Sopracordevole, Fabrizio Zanconati, Rudy Ippodrino

β-catenin-IRP2-primed iron availability to mitochondrial metabolism is druggable for active β-catenin-mediated cancer

Yuting Wu, Shuhui Yang, Luyang Han, Kezhuo Shang, Baohui Zhang, Xiaochen Gai, Weiwei Deng, Fangming Liu, Hongbing Zhang

Predisposition to cortical neurodegenerative changes in brains of hypertension prone rats

Moti Ben-Shabat, Yaseen Awad-Igbaria, Shifra Sela, Bella Gross, Yoram Yagil, Chana Yagil, Eilam Palzur

The involvement and therapeutic potential of lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway in arsenic trioxide-induced cardiotoxicity

Xiuyun Shen, Fengnan Zhi, Chunpeng Shi, Jincheng Xu, Yuqiu Chao, Juan Xu, Yanan Jiang, Yunlong Bai, Baofeng Yang

Upregulation of HMGB1 in tumor-associated macrophages induced by tumor cell-derived lactate further promotes colorectal cancer progression

Xinyi Gao, Shiqi Zhou, Zhaofu Qin, Dechuan Li, Yuping Zhu, Dening Ma

Targeting epigenetic features in clear cell sarcomas based on patient-derived cell lines

Christina Karner, Ines Anders, Djenana Vejzovic, Joanna Szkandera, Susanne Scheipl, Alexander J. A. Deutsch, Larissa Weiss, Klemens Vierlinger, Dagmar Kolb, Stefan Kühberger, Ellen Heitzer, Hansjörg Habisch, Fangrong Zhang, Tobias Madl, Birgit Reininger-Gutmann, Bernadette Liegl-Atzwanger, Beate Rinner

Pan-cancer onco-signatures reveal a novel mitochondrial subtype of luminal breast cancer with specific regulators

Ines Simeone, Michele Ceccarelli

ADAM12 promotes clear cell renal cell carcinoma progression and triggers EMT via EGFR/ERK signaling pathway

Jinming Xu, Yan Wang, Jiahao Jiang, Cong Yin, Bentao Shi

Leveraging a cuproptosis-based signature to predict the prognosis and drug sensitivity of cutaneous melanoma

Da Liu, Fan Yang, Tongtong Zhang, Rui Mao

Correction: HNRNPA2B1-mediated m6A modification of TLR4 mRNA promotes progression of multiple myeloma

Chuiming Jia, Yiwei Guo, Yao Chen, Xinya Wang, Qiuting Xu, Yu Zhang, Lina Quan

Fibrosis

Monica Pernia Marin, Mary Salvatore

Impact of the gut microbiota and associated metabolites on cardiometabolic traits, chronic diseases and human longevity: a Mendelian randomization study

Eloi Gagnon, Patricia L. Mitchell, Hasanga D. Manikpurage, Erik Abner, Nele Taba, Tõnu Esko, Nooshin Ghodsian, Sébastien Thériault, Patrick Mathieu, Benoit J. Arsenault

Characterization of large extracellular vesicles (L-EV) derived from human regulatory macrophages (Mreg): novel mediators in wound healing and angiogenesis?

Martin Albrecht, Lars Hummitzsch, Rene Rusch, Katharina Heß, Markus Steinfath, Jochen Cremer, Frank Lichte, Fred Fändrich, Rouven Berndt, Karina Zitta

A prediction model for the impact of environmental and genetic factors on cardiovascular events: development in a salt substitutes population

Dan Zhao, Hao Sun, Huamin Li, Chaoxiu Li, Bo Zhou

Development and validation of postoperative circulating tumor DNA combined with clinicopathological risk factors for recurrence prediction in patients with stage I-III colorectal cancer

Zhaoya Gao, Dandan Huang, Hui Chen, Yong Yang, Ke An, Changmin Ding, Zheping Yuan, Zhichao Zhai, Pengfei Niu, Qingkun Gao, Jinping Cai, Qingmin Zeng, Yanzhao Wang, Yuming Hong, Wanshui Rong, Wensheng Huang, Fuming Lei, Xiaodong Wang, Shiqing Chen, Xiaochen Zhao, Yuezong Bai, Jin Gu

High proportion of circulating CD8 + CD28- senescent T cells is an independent predictor of distant metastasis in nasopharyngeal carcinoma after radiotherapy

Xiaotian Xu, Fangze Wei, Lin Xiao, Runye Wu, Baojun Wei, Shengkai Huang, Junlin Yi, Wei Cui

Impact of total cerebral small vessel disease score on ophthalmic artery morphologies and hemodynamics

Jia-lin Wang, Xue-ru Cheng, Zhao-yang Meng, Yan-ling Wang

Role of mitochondrial metabolic disorder and immune infiltration in diabetic cardiomyopathy: new insights from bioinformatics analysis

Cheng Peng, Yanxiu Zhang, Xueyan Lang, Yao Zhang

Evaluation of serum miRNAs expression in frail and robust subjects undergoing multicomponent exercise protocol (VIVIFRAIL)

Simone Agostini, Roberta Mancuso, Lorenzo Agostino Citterio, Gabriela Alexandra Mihali, Beatrice Arosio, Mario Clerici

Overview of microbial profiles in human hepatocellular carcinoma and adjacent nontumor tissues

Yuting He, Qiyao Zhang, Xiao Yu, Shuijun Zhang, Wenzhi Guo

Proteomic analysis predicts anti-angiogenic resistance in recurred glioblastoma

Hanwool Jeon, Joonho Byun, Hayeong Kang, Kyunggon Kim, Eunyeup Lee, Jeong Hoon Kim, Chang Ki Hong, Sang Woo Song, Young-Hoon Kim, Sangjoon Chong, Jae Hyun Kim, Soo Jeong Nam, Ji Eun Park, Seungjoo Lee

PSAT1 positively regulates the osteogenic lineage differentiation of periodontal ligament stem cells through the ATF4/PSAT1/Akt/GSK3β/β-catenin axis

Linglu Jia, Dongfang Li, Ya-Nan Wang, Dongjiao Zhang, Xin Xu

The soluble epoxide hydrolase inhibitor TPPU improves comorbidity of chronic pain and depression via the AHR and TSPO signaling

Ailin Luo, Zifeng Wu, Shan Li, Cindy B. McReynolds, Di Wang, Hanyu Liu, Chaoli Huang, Teng He, Xinying Zhang, Yuanyuan Wang, Cunming Liu, Bruce D. Hammock, Kenji Hashimoto, Chun Yang

Enterococcus faecalis promotes the progression of colorectal cancer via its metabolite: biliverdin

Li Zhang, Jing Liu, Mingxia Deng, Xiangliu Chen, Lushun Jiang, Jiajie Zhang, Lisheng Tao, Wei Yu, Yunqing Qiu

Identification and validation of a novel survival prediction model based on the T-cell phenotype in the tumor immune microenvironment and peripheral blood for gastric cancer prognosis

Jing Ma, Jianhui Li, Nan He, Meirui Qian, Yuanyuan Lu, Xin Wang, Kaichun Wu

VEGF-A enhances the cytotoxic function of CD4+ cytotoxic T cells via the VEGF-receptor 1/VEGF-receptor 2/AKT/mTOR pathway

Ziyi Chen, Meng Zhang, Yufeng Liu, Zhe Chen, Ling Wang, Wenjuan Wang, Jincheng Wang, Mingqian He, Bingyin Shi, Yue Wang

Clinical impact of volume of disease and time of metastatic disease presentation on patients receiving enzalutamide or abiraterone acetate plus prednisone as first-line therapy for metastatic castration-resistant prostate cancer

Pier Vitale Nuzzo, Filippo Pederzoli, Calogero Saieva, Elisa Zanardi, Giuseppe Fotia, Andrea Malgeri, Sabrina Rossetti, Loana Valenca Bueno, Livia Maria Q. S. Andrade, Anna Patrikidou, Ricardo Pereira Mestre, Mikol Modesti, Sandro Pignata, Giuseppe Procopio, Giuseppe Fornarini, Ugo De Giorgi, Antonio Russo, Edoardo Francini

Incorporating knowledge of disease-defining hub genes and regulatory network into a machine learning-based model for predicting treatment response in lupus nephritis after the first renal flare

Ding-Jie Lee, Ping-Huang Tsai, Chien-Chou Chen, Yang-Hong Dai

Loss of miR-26b-5p promotes gastric cancer progression via miR-26b-5p-PDE4B/CDK8-STAT3 feedback loop

Tingting Xu, Mengyan Xie, Xinming Jing, Huning Jiang, Xi Wu, Xinzhu Wang, Yongqian Shu

Prognostic value of genetic aberrations and tumor immune microenvironment in primary acral melanoma

Rong Huang, Gaigai Shen, Yu Ren, Kelin Zheng, Jiayu Wang, Yan Shi, Jiani C. Yin, Lanqun Qin, Guiying Zhang, Mengke Zhao, Xinyu Su, Luqiao Li, Fufeng Wang, Yang Shao, Baorui Liu, Zhengyun Zou

Prognostic value of the pretreatment systemic immune-inflammation index in patients with prostate cancer: a systematic review and meta-analysis

Linghao Meng, Yujia Yang, Xu Hu, Ruohan Zhang, Xiang Li

Cancer functional states-based molecular subtypes of gastric cancer

Qi Zhou, Yiwu Yuan, Hao Lu, Xueqin Li, Ziyang Liu, Jinheng Gan, Zhenqi Yue, Jiping Wu, Jie Sheng, Lin Xin

Sirt3 restricts tumor initiation via promoting LONP1 deacetylation and K63 ubiquitination

Liyi Wu, Xinyi Yan, Ruibo Sun, Ye Ma, Wanyu Yao, Baogui Gao, Qingyuan Zhang, Junxiong You, Hao Wang, Qinrui Han, Xuegang Sun

Intestinal epithelium-specific Fut2 deficiency promotes colorectal cancer through down-regulating fucosylation of MCAM

Weijun Wang, Xuelian Tang, Caihan Duan, Shuxin Tian, Chaoqun Han, Wei Qian, Xin Jiang, Xiaohua Hou, Rong Lin

Circular RNA 0001789 sponges miR-140-3p and regulates PAK2 to promote the progression of gastric cancer

Jun You, Yinan Chen, Donghan Chen, Yongwen Li, Tinghao Wang, Jingtao Zhu, Qingqi Hong, Qiyuan Li

FYN: emerging biological roles and potential therapeutic targets in cancer

SanFei Peng, Yang Fu

Blockage of glycolysis by targeting PFKFB3 suppresses the development of infantile hemangioma

Kaiying Yang, Tong Qiu, Jiangyuan Zhou, Xue Gong, Xuepeng Zhang, Yuru Lan, Zixin Zhang, Yi Ji

Transcriptomics-proteomics Integration reveals alternative polyadenylation driving inflammation-related protein translation in patients with diabetic nephropathy

Tingting Zhao, Dongdong Zhan, Shuang Qu, Song Jiang, Wenhua Gan, Weisong Qin, Chunxia Zheng, Fang Cheng, Yinghui Lu, Mingwei Liu, Jinsong Shi, Hongwei Liang, Yi Wang, Jun Qin, Ke Zen, Zhihong Liu

Bi-anti therapy for SARS-CoV-2 infection among mild/moderate patients to prevent coronavirus disease 2019 from progressing to severe disease

Jian Xu

Associations of types of grains and lifestyle with all-cause mortality among Chinese adults aged 65 years or older: a prospective cohort study

Yongjie Chen, Boran Sun, Caihong Wang, Keming Zhang, Wenli Lu, Guowei Huang

Young and undamaged recombinant albumin alleviates T2DM by improving hepatic glycolysis through EGFR and protecting islet β cells in mice

Hongyi Liu, Anji Ju, Xuan Dong, Zongrui Luo, Jiaze Tang, Boyuan Ma, Yan Fu, Yongzhang Luo

Association between sleep duration and metabolic syndrome: linear and nonlinear Mendelian randomization analyses

Yannis Yan Liang, Jie Chen, Miaoguan Peng, Jiajin Zhou, Xinru Chen, Xiao Tan, Ningjian Wang, Huan Ma, Lan Guo, Jihui Zhang, Yun-Kwok Wing, Qingshan Geng, Sizhi Ai

A novel model for predicting prolonged stay of patients with type-2 diabetes mellitus: a 13-year (2010–2022) multicenter retrospective case–control study

Juntao Tan, Zhengyu Zhang, Yuxin He, Yue Yu, Jing Zheng, Yunyu Liu, Jun Gong, Jianjun Li, Xin Wu, Shengying Zhang, Xiantian Lin, Yuxi Zhao, Xiaoxin Wu, Songjia Tang, Jingjing Chen, Wenlong Zhao

Robust SNP-based prediction of rheumatoid arthritis through machine-learning-optimized polygenic risk score

Ashley J. W. Lim, C. Tera Tyniana, Lee Jin Lim, Justina Wei Lynn Tan, Ee Tzun Koh, Andrea Ee Ling Ang, Grace Yin Lai Chan, Madelynn Tsu-Li Chan, Faith Li-Ann Chia, Hiok Hee Chng, Choon Guan Chua, Hwee Siew Howe, Li Wearn Koh, Kok Ooi Kong, Weng Giap Law, Samuel Shang Ming Lee, Tsui Yee Lian, Xin Rong Lim, Jess Mung Ee Loh, Mona Manghani, Sze-Chin Tan, Claire Min-Li Teo, Bernard Yu-Hor Thong, Paula Permatasari Tjokrosaputro, Chuanhui Xu, Samuel S. Chong, Chiea Chuen Khor, Khai Pang Leong, Caroline G. Lee

Multi-omics data reveals the important role of glycerophospholipid metabolism in the crosstalk between gut and brain in depression

Jing Xie, Qi Zhong, Wen-tao Wu, Jian-jun Chen

Glucose metabolic reprogramming and its therapeutic potential in obesity-associated endometrial cancer

Pengzhu Huang, Xiangqin Fan, Hongfei Yu, Kaiwen Zhang, Huanrong Li, Yingmei Wang, Fengxia Xue

Alterations in the human oral microbiota in systemic lupus erythematosus

Jinyan Guo, Guangying Cui, Wei Huang, Zhaohui Zheng, Tianfang Li, Guanmin Gao, Zhen Huang, Yuwei Zhan, Suying Ding, Shengyun Liu, Zujiang Yu, Zhigang Ren

Correction: Current advances in gene therapy of mitochondrial diseases

Vladislav O. Soldatov, Marina V. Kubekina, Marina Yu. Skorkina, Andrei E. Belykh, Tatiana V. Egorova, Mikhail V. Korokin, Mikhail V. Pokrovskiy, Alexey V. Deykin, Plamena R. Angelova

Genetic dissection of the impact of lncRNA AI662270 during the development of atherosclerosis

Yang Hong, Yue Zhang, Hui Chen, Xueqing Tang, Hongrui Zhao, Ziyu Meng, Xueling Jia, Wenfeng Liu, Xiaohan Li, Lin Wang, Xinrui Zhong, Xuefeng Bai, Heyang Sun, Philipp Kopylov, Bestavashvili Afina, Dmitry Shchekochikhin, Yong Zhang, Xin Liu, Yuhua Fan

Presence of depression and anxiety with distinct patterns of pharmacological treatments before the diagnosis of chronic fatigue syndrome: a population-based study in Taiwan

Chi Chen, Hei-Tung Yip, Kam-Hang Leong, Wei-Cheng Yao, Chung-Lieh Hung, Ching-Huang Su, Chien-Feng Kuo, Shin-Yi Tsai

Abnormal signal pathways and tumor heterogeneity in osteosarcoma

Yifeng Sun, Chunming Zhang, Qiongxuan Fang, Wenqiang Zhang, Wei Liu

Renal nerve stimulation identifies renal innervation and optimizes the strategy for renal denervation in canine

Hang Liu, Yidan Li, Hao Zhou, Weijie Chen, Yanping Xu, Huaan Du, Bo Zhang, Tianli Xia, Dan Li, Zhenhong Ou, Ruotian Tang, Qingsong Chen, Binyi Zhao, Yuehui Yin

Role of noncoding RNAs in orthodontic tooth movement: new insights into periodontium remodeling

Yuming Chen, Chao Zhang

Inhibition of MMPs supports amoeboid angiogenesis hampering VEGF-targeted therapies via MLC and ERK 1/2 signaling

Anastasia Chillà, Cecilia Anceschi, Elena Frediani, Francesca Scavone, Tommaso Del Rosso, Giuseppe Pelagio, Antonio Tufaro, Giuseppe De Palma, Mario Del Rosso, Gabriella Fibbi, Paola Chiarugi, Anna Laurenzana, Francesca Margheri

ApoE4 associated with severe COVID-19 outcomes via downregulation of ACE2 and imbalanced RAS pathway

Feng Chen, Yanting Chen, Qiongwei Ke, Yongxiang Wang, Zheng Gong, Xiongjin Chen, Yujie Cai, Shengnan Li, Yuanhong Sun, Xiaoping Peng, Yao Ji, Tianzhen Zhang, Wenxian Wu, Lili Cui, Yan Wang

The genetic basis of multiple system atrophy

Fan Shuen Tseng, Joel Qi Xuan Foo, Aaron Shengting Mai, Eng-King Tan

The members of the miR-148/152 family inhibit cancer stem cell-like properties in gastric cancer via negative regulation of ITGA5

Xiaoying Li, Lin Li, Jiangying Wu

BCG-induced trained immunity: history, mechanisms and potential applications

Jingjing Chen, Li Gao, Xinya Wu, Yuxin Fan, Meixiao Liu, Li Peng, Jieqin Song, Bingxue Li, Aihua Liu, Fukai Bao

Association between oxidative stress, mitochondrial function of peripheral blood mononuclear cells and gastrointestinal cancers

Weili Liu, Yuan Gao, Hua Li, Xinxing Wang, Min Jin, Zhiqiang Shen, Dong Yang, Xuelian Zhang, Zilin Wei, Zhaoli Chen, Junwen Li

BAX as the mediator of C-MYC sensitizes acute lymphoblastic leukemia to TLR9 agonists

Ling Bai, Lei Zhou, Wei Han, Jingtao Chen, Xiaoyi Gu, Zheng Hu, Yongguang Yang, Wei Li, Xiaoying Zhang, Chao Niu, Yongchong Chen, Hui Li, Jiuwei Cui

Bioinformatics analyses of combined databases identify shared differentially expressed genes in cancer and autoimmune disease

Yuan Sui, Shuping Li, Xue-Qi Fu, Zhizhuang Joe Zhao, Shu Xing

Cellular senescence in the response of HR+ breast cancer to radiotherapy and CDK4/6 inhibitors

Vanessa Klapp, Aitziber Buqué, Norma Bloy, Ai Sato, Takahiro Yamazaki, Xi Kathy Zhou, Silvia C. Formenti, Lorenzo Galluzzi, Giulia Petroni

Discovery of potential FGFR3 inhibitors via QSAR, pharmacophore modeling, virtual screening and molecular docking studies against bladder cancer

Mahmoud Ganji, Shohreh Bakhshi, Alireza Shoari, Reza Ahangari Cohan

Symptom-based clusters in people with ME/CFS: an illustration of clinical variety in a cross-sectional cohort

Anouk W. Vaes, Maarten Van Herck, Qichen Deng, Jeannet M. Delbressine, Leonard A. Jason, Martijn A. Spruit

Cell–cell communications shape tumor microenvironment and predict clinical outcomes in clear cell renal carcinoma

Liu-xun Chen, Shen-jie Zeng, Xv-dong Liu, Hai-bin Tang, Jia-wu Wang, Qing Jiang

Focus on global public health, screening for tuberculosis using colour-coded electronic health signs similar to that employed for screening coronavirus disease 2019 in China

Jian Xu

Spermatogenesis associated serine rich 2 like plays a prognostic factor and therapeutic target in acute myeloid leukemia by regulating the JAK2/STAT3/STAT5 axis

Fenglin Li, Wenle Ye, Yiyi Yao, Wenwen Wei, Xiangjie Lin, Haihui Zhuang, Chenying Li, Xia Li, Qing Ling, Chao Hu, Xin Huang, Yu Qian, Shihui Mao, Jiansong Huang, Ying Lu, Jie Jin

Low muscle mass in lung cancer is associated with an inflammatory and immunosuppressive tumor microenvironment

Sarah Santiloni Cury, Diogo de Moraes, Jakeline Santos Oliveira, Paula Paccielli Freire, Patricia Pintor dos Reis, Miguel Luiz Batista Jr, Érica Nishida Hasimoto, Robson Francisco Carvalho

Alternation of the gut microbiota in irritable bowel syndrome: an integrated analysis based on multicenter amplicon sequencing data

Han Chen, Rong Ou, Nana Tang, Wei Su, Ruoyun Yang, Xin Yu, Guoxin Zhang, Jianhua Jiao, Xiaoying Zhou

Liquid biopsies: the future of cancer early detection

Siobhan Connal, James M. Cameron, Alexandra Sala, Paul M. Brennan, David S. Palmer, Joshua D. Palmer, Haley Perlow, Matthew J. Baker

An initial study on the predictive value using multiple MRI characteristics for Ki-67 labeling index in glioma

Ningfang Du, Weiquan Shu, Kefeng Li, Yao Deng, Xinxin Xu, Yao Ye, Feng Tang, Renling Mao, Guangwu Lin, Shihong Li, Xuhao Fang

LINC00478-derived novel cytoplasmic lncRNA LacRNA stabilizes PHB2 and suppresses breast cancer metastasis via repressing MYC targets

Rong Guo, Yonghui Su, Qi Zhang, Bingqiu Xiu, Sheng Huang, Weiru Chi, Liyi Zhang, Lun Li, Jianjing Hou, Jia Wang, Jiajian Chen, Yayun Chi, Jingyan Xue, Jiong Wu

Hepatocyte SGK1 activated by hepatic ischemia-reperfusion promotes the recurrence of liver metastasis via IL-6/STAT3

Xiangdong Li, Ziyi Wang, Chenyu Jiao, Yu Zhang, Nan Xia, Wenjie Yu, Xuejiao Chen, Likalamu Pascalia Wikana, Yue Liu, Linfeng Sun, Minhao Chen, Yuhao Xiao, Yuhua Shi, Sheng Han, Liyong Pu

Safety and efficacy of first-in-man intrathecal injection of human astrocytes (AstroRx®) in ALS patients: phase I/IIa clinical trial results

Marc Gotkine, Yoseph Caraco, Yossef Lerner, Simcha Blotnick, Maor Wanounou, Shalom Guy Slutsky, Judith Chebath, Graciela Kuperstein, Elena Estrin, Tamir Ben-Hur, Arik Hasson, Kfir Molakandov, Tehila Sonnenfeld, Yafit Stark, Ariel Revel, Michel Revel, Michal Izrael

Immune profiling of SARS-CoV-2 epitopes in asymptomatic and symptomatic pediatric and adult patients

Anna Lucia Tornesello, Chiara Botti, Alberto Micillo, Francesco Labonia, Sergio Arpino, Maria Antonietta Isgrò, Serena Meola, Luigi Russo, Ernesta Cavalcanti, Silvia Sale, Carmine Nicastro, Luigi Atripaldi, Noemy Starita, Andrea Cerasuolo, Ulf Reimer, Pavlo Holenya, Luigi Buonaguro, Franco M. Buonaguro, Maria Lina Tornesello

Tumor-associated macrophages and Tregs influence and represent immune cell infiltration of muscle-invasive bladder cancer and predict prognosis

Florestan J. Koll, Severine Banek, Luis Kluth, Jens Köllermann, Katrin Bankov, Felix K.-H. Chun, Peter J. Wild, Andreas Weigert, Henning Reis

HDAC inhibitor ITF2357 reduces resistance of mutant-KRAS non-small cell lung cancer to pemetrexed through a HDAC2/miR-130a-3p-dependent mechanism

Jian Cui, Fei Xu, Wei Bai, Tiantian Zhao, Junbo Hong, Wei Zuo

Characterization of the intestinal fungal microbiome in patients with hepatocellular carcinoma

Lilong Zhang, Chen Chen, Dongqi Chai, Chunlei Li, Zhendong Qiu, Tianrui Kuang, Li Liu, Wenhong Deng, Weixing Wang

Genome-wide polygenic risk score for major osteoporotic fractures in postmenopausal women using associated single nucleotide polymorphisms

Qing Wu, Jongyun Jung

Very low-calorie ketogenic diet (VLCKD): an antihypertensive nutritional approach

Luigi Barrea, Ludovica Verde, Pasquale Santangeli, Stefania Lucà, Annamaria Docimo, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri

Anti-oncogenic effects of dutasteride, a dual 5-alpha reductase inhibitor and a drug for benign prostate hyperplasia, in bladder cancer

Jaekwon Seok, Hee Jeong Kwak, Yeonjoo Kwak, Moonjung Lee, Kyoung Sik Park, Aram Kim, Ssang-Goo Cho

Association of milk consumption with all-cause mortality and cardiovascular outcomes: a UK Biobank based large population cohort study

Jian Zhou, Ziyi Wu, Zhengjun Lin, Wanchun Wang, Rongjun Wan, Tang Liu

Soluble low-density lipoprotein receptor-related protein 1 as a surrogate marker of carotid plaque inflammation assessed by 18F-FDG PET in patients with a recent ischemic stroke

Eduardo Garcia, Pol Camps-Renom, Núria Puig, Alejandro Fernández-Leon, Ana Aguilera-Simón, Aleyda Benitez-Amaro, Arnau Solé, David Vilades, José Luis Sanchez-Quesada, Joan Martí-Fàbregas, Elena Jiménez-Xarrié, Sonia Benitez, Vicenta Llorente-Cortés

P2RX7 promotes osteosarcoma progression and glucose metabolism by enhancing c-Myc stabilization

Gaohong Sheng, Yuan Gao, Qing Ding, Ruizhuo Zhang, Tianqi Wang, Shaoze Jing, Hongqi Zhao, Tian Ma, Hua Wu, Yong Yang

Emerging therapeutic strategies for unmet need in neovascular age-related macular degeneration

Levon M. Khachigian, Gerald Liew, Kelvin Y. C. Teo, Tien Y. Wong, Paul Mitchell

FLI1 regulates radiotherapy resistance in nasopharyngeal carcinoma through TIE1-mediated PI3K/AKT signaling pathway

Enni Chen, Jiajia Huang, Miao Chen, Jiawei Wu, Puyun Ouyang, Xiaonan Wang, Dingbo Shi, Zhiqiao Liu, Wancui Zhu, Haohui Sun, Shanshan Yang, Baoyu Zhang, Wuguo Deng, Huijuan Qiu, Fangyun Xie

Advances in photobiomodulation for cognitive improvement by near-infrared derived multiple strategies

Wei-tong Pan, Pan-miao Liu, Daqing Ma, Jian-jun Yang

Identification and validation of a novel prognostic signature based on mitochondria and oxidative stress related genes for glioblastoma

Shiao Tong, Minqi Xia, Yang Xu, Qian Sun, Liguo Ye, Fanen Yuan, Yixuan Wang, Jiayang Cai, Zhang Ye, Daofeng Tian

The relationship of reproductive factors with adiposity and body shape indices changes overtime: findings from a community-based study

Mina Amiri, Maryam Mousavi, Fereidoun Azizi, Fahimeh Ramezani Tehrani

Modeling of Fabry disease nephropathy using patient derived human induced pluripotent stem cells and kidney organoid system

Sheng Cui, Xianying Fang, Hanbi Lee, Yoo Jin Shin, Eun-Sil Koh, Sungjin Chung, Hoon Suk Park, Sun Woo Lim, Kang In Lee, Jae Young Lee, Chul Woo Yang, Byung Ha Chung

Low-intensity pulsed ultrasound triggers a beneficial neuromodulation in dementia mice with chronic cerebral hypoperfusion via activation of hippocampal Fndc5/irisin signaling

Degang Song, Xiaomin Chen, Na Zhou, Yi Yuan, Shuo Geng, Cong Zhang, Zhe Zhao, Xingran Wang, Xinran Bao, Xifa Lan, Xiangjian Zhang

IL-6 as new prognostic factor in patients with advanced cutaneous squamous cell carcinoma treated with cemiplimab

Domenico Mallardo, Ester Simeone, Lucia Festino, Marilena Tuffanelli, Vito Vanella, Claudia Trojaniello, Maria Grazia Vitale, Margaret Ottaviano, Mariaelena Capone, Gabriele Madonna, Francesca Sparano, Eleonora Cioli, Luigi Scarpato, Marco Palla, Rossella Di Trolio, Paolo Meinardi, Corrado Caracò, Gerardo Ferrara, Paolo Muto, Ernesta Cavalcanti, Paolo Antonio Ascierto

Whole transcriptome analysis to explore the impaired immunological features in critically ill elderly patients with sepsis

I-Chieh Chen, Hsin-Hua Chen, Yu-Han Jiang, Tzu-Hung Hsiao, Tai-Ming Ko, Wen-Cheng Chao

Weigh change across adulthood is related to the presence of NAFLD: results from NHANES III

Lili Wang, Jiayi Yi, Jiajun Guo, Xiangpeng Ren

Transcranial direct current stimulation to the left dorsolateral prefrontal cortex enhances early dexterity skills with the left non-dominant hand: a randomized controlled trial

Akihiro Watanabe, Daisuke Sawamura, Hisato Nakazono, Yukina Tokikuni, Hiroshi Miura, Kazuhiro Sugawara, Kanako Fuyama, Harukazu Tohyama, Susumu Yoshida, Shinya Sakai

Large-scale in vitro microdosimetry via live cell microscopy imaging: implications for radiosensitivity and RBE evaluations in alpha-emitter radiopharmaceutical therapy

Remco Bastiaannet, Ioanna Liatsou, Robert F Hobbs, George Sgouros

Matrine alleviates depressive-like behaviors via modulating microbiota–gut–brain axis in CUMS-induced mice

Ming Zhang, Aoqiang Li, Qifang Yang, Jingyi Li, Lihua Zheng, Guannan Wang, Ying Sun, Yanxin Huang, Muqing Zhang, Zhenbo Song, Lei Liu

Metabolic classifications of renal cell carcinoma reveal intrinsic connections with clinical and immune characteristics

Le Li, Zheng Chao, Un Waikeong, Jun Xiao, Yue Ge, Yanan Wang, Zezhong Xiong, Sheng Ma, Zhihua Wang, Zhiquan Hu, Xing Zeng

Valtrate, an iridoid compound in Valeriana, elicits anti-glioblastoma activity through inhibition of the PDGFRA/MEK/ERK signaling pathway

Xuemeng Liu, Yaotian Hu, Zhiyi Xue, Xun Zhang, Xiaofei Liu, Guowei Liu, Muzi Wen, Anjing Chen, Bin Huang, Xingang Li, Ning Yang, Jian Wang

Modeling the enigma of complex disease etiology

Lynn M. Schriml, Richard Lichenstein, Katharine Bisordi, Cynthia Bearer, J. Allen Baron, Carol Greene

The role of non-steroidal anti-inflammatory drugs as adjuncts to periodontal treatment and in periodontal regeneration

Jianhan Ren, Melissa Rachel Fok, Yunfan Zhang, Bing Han, Yifan Lin

Identification of MET fusions as novel therapeutic targets sensitive to MET inhibitors in lung cancer

Dantong Sun, Weizheng Wu, Li Wang, Jialin Qu, Qiman Han, Huiyun Wang, Shanai Song, Ning Liu, Yongjie Wang, Helei Hou

Integrated multi-omics analyses and functional validation reveal TTK as a novel EMT activator for endometrial cancer

Yu Miao, Yosuke Konno, Baojin Wang, Lin Zhu, Tianyue Zhai, Kei Ihira, Noriko Kobayashi, Hidemichi Watari, Xin Jin, Junming Yue, Peixin Dong, Mingyan Fang

Global landscape of SARS-CoV-2 mutations and conserved regions

Mohammad Hadi Abbasian, Mohammadamin Mahmanzar, Karim Rahimian, Bahar Mahdavi, Samaneh Tokhanbigli, Bahman Moradi, Mahsa Mollapour Sisakht, Youping Deng

LINC00543 promotes colorectal cancer metastasis by driving EMT and inducing the M2 polarization of tumor associated macrophages

Jinsen Zheng, Rongzhang Dou, Xinyao Zhang, Bo Zhong, Chenggang Fang, Qian Xu, Ziyang Di, Sihao Huang, Zaihuan Lin, Jialin Song, Shuyi Wang, Bin Xiong

Muscle distribution in relation to all-cause and cause-specific mortality in young and middle-aged adults

Chen-An Liu, Tong Liu, Yi-Zhong Ge, Meng-Meng Song, Guo-Tian Ruan, Shi-Qi Lin, Hai-Lun Xie, Jin-Yu Shi, Xin Zheng, Yue Chen, Liuyi Shen, Li Deng, Han-Ping Shi

Metformin and long non-coding RNAs in breast cancer

Morteza Gholami, Zeynab Nickhah Klashami, Pirooz Ebrahimi, Amir Ali Mahboobipour, Amir Salehi Farid, Aida Vahidi, Marziyeh Zoughi, Mojgan Asadi, Mahsa M. Amoli

Lactoferrin suppresses the progression of colon cancer under hyperglycemia by targeting WTAP/m6A/NT5DC3/HKDC1 axis

Huiying Li, Chaonan Li, Boyang Zhang, Hongpeng Jiang

Precision information extraction for rare disease epidemiology at scale

William Z. Kariampuzha, Gioconda Alyea, Sue Qu, Jaleal Sanjak, Ewy Mathé, Eric Sid, Haley Chatelaine, Arjun Yadaw, Yanji Xu, Qian Zhu

Nanoscale, antigen encounter-dependent, IL-12 delivery by CAR T cells plus PD-L1 blockade for cancer treatment

Zhifen Yang, Violena Pietrobon, Maggie Bobbin, Ofir Stefanson, Jin Yang, Angshumala Goswami, Bennett Alphson, Hana Choi, Khristina Magallanes, Qi Cai, David Barrett, Bing Wang, Lei S. Qi, Francesco M. Marincola

Caprin-1 plays a role in cell proliferation and Warburg metabolism of esophageal carcinoma by regulating METTL3 and WTAP

Yan Gao, Lingling Yuan, Changbin Ke, Zhijun Pei, Xiaobo Liu, Ruimin Wu, Xueyan Kui, Yanmin Zhang

Expanding the phenome and variome of the ROBO-SLIT pathway in congenital heart defects: toward improving the genetic testing yield of CHD

Hager Jaouadi, Chris Jopling, Fanny Bajolle, Alexis Théron, Adèle Faucherre, Hilla Gerard, Sarab Al Dybiat, Caroline Ovaert, Damien Bonnet, Jean-François Avierinos, Stéphane Zaffran

Automating iPSC generation to enable autologous photoreceptor cell replacement therapy

Laura R. Bohrer, Nicholas E. Stone, Nathaniel K. Mullin, Andrew P. Voigt, Kristin R. Anfinson, Jessica L. Fick, Viviane Luangphakdy, Bradley Hittle, Kimerly Powell, George F. Muschler, Robert F. Mullins, Edwin M. Stone, Budd A. Tucker

Immunogenic cell death in cancer: concept and therapeutic implications

Lorenzo Galluzzi, Oliver Kepp, Erik Hett, Guido Kroemer, Francesco M. Marincola

MiR-200/183 family-mediated module biomarker for gastric cancer progression: an AI-assisted bioinformatics method with experimental functional survey

Wenying Yan, Yuqi Chen, Guang Hu, Tongguo Shi, Xingyi Liu, Juntao Li, Linqing Sun, Fuliang Qian, Weichang Chen

Epigenetics as a versatile regulator of fibrosis

Yangdan Liu, Dongsheng Wen, Chiakang Ho, Li Yu, Danning Zheng, Steven O’Reilly, Ya Gao, Qingfeng Li, Yifan Zhang

Valproic acid inhibits cell growth in both MCF-7 and MDA-MB231 cells by triggering different responses in a cell type-specific manner

Francesca Giordano, Alessandro Paolì, Martina Forastiero, Stefania Marsico, Francesca De Amicis, Mariangela Marrelli, Giuseppina Daniela Naimo, Loredana Mauro, Maria Luisa Panno

Landscape analysis of m6A modification regulators related biological functions and immune characteristics in myasthenia gravis

Shuang Li, Hui Liu, Zhe Ruan, Rongjing Guo, Chao Sun, Yonglan Tang, Xiaoxi Huang, Ting Gao, Sijia Hao, Huanhuan Li, Na Song, Yue Su, Fan Ning, Zhuyi Li, Ting Chang

CD206+ tumor-associated macrophages interact with CD4+ tumor-infiltrating lymphocytes and predict adverse patient outcome in human laryngeal squamous cell carcinoma

Yu Heng, Xiaoke Zhu, Hanqing Lin, Ma jingyu, Xuping Ding, Lei Tao, Liming Lu

Correction: Transplanted allogeneic cardiac progenitor cells secrete GDF-15 and stimulate an active immune remodeling process in the ischemic myocardium

Rachana Mishra, Progyaparamita Saha, Srinivasa Raju Datla, Pranav Mellacheruvu, Muthukumar Gunasekaran, Sameer Ahmad Guru, Xuebin Fu, Ling Chen, Roberto Bolli, Sudhish Sharma, Sunjay Kaushal

Short term starvation potentiates the efficacy of chemotherapy in triple negative breast cancer via metabolic reprogramming

Ioannis S. Pateras, Chloe Williams, Despoina D. Gianniou, Aggelos T. Margetis, Margaritis Avgeris, Pantelis Rousakis, Aigli-Ioanna Legaki, Peter Mirtschink, Wei Zhang, Konstantina Panoutsopoulou, Anastasios D. Delis, Stamatis N. Pagakis, Wei Tang, Stefan Ambs, Ulrika Warpman Berglund, Thomas Helleday, Anastasia Varvarigou, Antonios Chatzigeorgiou, Anders Nordström, Ourania E. Tsitsilonis, Ioannis P. Trougakos, Jonathan D. Gilthorpe, Teresa Frisan

Correction: The involvement and therapeutic potential of lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway in arsenic trioxide-induced cardiotoxicity

Xiuyun Shen, Fengnan Zhi, Chunpeng Shi, Jincheng Xu, Yuqiu Chao, Juan Xu, Yanan Jiang, Yunlong Bai, Baofeng Yang

The link between glycemic control measures and eye microvascular complications in a clinical cohort of type 2 diabetes with microRNA-223-3p signature

Sahar I. Da’as, Ikhlak Ahmed, Waseem H. Hasan, Doua A. Abdelrahman, Elbay Aliyev, Sabah Nisar, Ajaz Ahmad Bhat, Mugdha V. Joglekar, Anandwardhan A. Hardikar, Khalid A. Fakhro, Ammira S. Al-Shabeeb Akil

Metagenomic analysis examines oral microbiome changes and interplay with immune response following prenatal total oral rehabilitation

Tong Tong Wu, Michael Sohn, Samantha Manning, Robert Beblavy, Steven Gill, Sally Quataert, Shruti Vasani, Hoonji Jang, Yan Zeng, Jennifer Bruno, Adriana Vazquez, Kevin Fiscella, Jin Xiao

The spatiotemporal matching pattern of Ezrin/Periaxin involved in myoblast differentiation and fusion and Charcot-Marie-Tooth disease-associated muscle atrophy

Ruo-nan Zhang, Xin Bao, Yun Liu, Yan Wang, Xing-Yuan Li, Ge Tan, Magdaleena Naemi Mbadhi, Wei Xu, Qian Yang, Lu-yuan Yao, Long Chen, Xiao-ying Zhao, Chang-qing Hu, Jing-xuan Zhang, Hong-tao Zheng, Yan Wu, Shan Li, Shao-juan Chen, Shi-you Chen, Jing Lv, Liu-liu Shi, Jun-ming Tang

Integration of longitudinal deep-radiomics and clinical data improves the prediction of durable benefits to anti-PD-1/PD-L1 immunotherapy in advanced NSCLC patients

Benito Farina, Ana Delia Ramos Guerra, David Bermejo-Peláez, Carmelo Palacios Miras, Andrés Alcazar Peral, Guillermo Gallardo Madueño, Jesús Corral Jaime, Anna Vilalta-Lacarra, Jaime Rubio Pérez, Arrate Muñoz-Barrutia, German R. Peces-Barba, Luis Seijo Maceiras, Ignacio Gil-Bazo, Manuel Dómine Gómez, María J. Ledesma-Carbayo

J-shape relationship between normal fasting plasma glucose and risk of type 2 diabetes in the general population: results from two cohort studies

Linfeng He, Wenbin Zheng, Zeyu Li, Lu Chen, Wen Kong, Tianshu Zeng

Identification of hub genes and potential molecular mechanisms related to radiotherapy sensitivity in rectal cancer based on multiple datasets

Pengfei Zhao, Hongchao Zhen, Hong Zhao, Yongjie Huang, Bangwei Cao

Lactation duration and lifetime progression to metabolic syndrome in women according to their history of gestational diabetes: a prospective longitudinal community-based cohort study

Maryam Farahmand, Maryam Rahmati, Fereidoun Azizi, Fahimeh Ramezani Tehrani

Immunotherapy trials in Parkinson’s disease: challenges

Bin Xiao, Eng-King Tan

TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury

Wen-Jing Zhong, Jun Zhang, Jia-Xi Duan, Chen-Yu Zhang, Sheng-Chao Ma, Yu-Sheng Li, Nan-Shi-Yu Yang, Hui-Hui Yang, Jian-Bing Xiong, Cha-Xiang Guan, Zhi-Xing Jiang, Zhi-Jian You, Yong Zhou

Correction: Good practice in medicine and biology: scientific integrity needs global bioethics

Henri-Corto Stoeklé, Achille Ivasilevitch, Christian Hervé

Correction: Lymphatic metastasis-associated circRNA‒miRNA‒mRNA network for exploring the pathogenesis and therapeutic target of triple negative breast cancer based on whole-transcriptome sequencing analysis: an experimental verification study

Jiayue Luo, Dong Cao, Chuwen Hu, Zhen Liang, Yuanping Zhang, Jianguo Lai

Identification of novel immune subtypes and potential hub genes of patients with psoriasis

Yingxi Li, Lin Li, Yao Tian, Jing Luo, Junkai Huang, Litao Zhang, Junling Zhang, Xiaoxia Li, Lizhi Hu

APE1 promotes non-homologous end joining by initiating DNA double-strand break formation and decreasing ubiquitination of artemis following oxidative genotoxic stress

Qin Zhang, Lujie Yang, Han Gao, Xunjie Kuang, He Xiao, Chen Yang, Yi Cheng, Lei Zhang, Xin Guo, Yong Zhong, Mengxia Li

Targeting KK-LC-1 inhibits malignant biological behaviors of triple-negative breast cancer

Xudong Zhu, Jiawen Bu, Tong zhu, Yi Jiang

CRS: a circadian rhythm score model for predicting prognosis and treatment response in cancer patients

Yuwei Liu, Shuang Guo, Yue Sun, Caiyu Zhang, Jing Gan, Shangwei Ning, Junwei Wang

CircDNAJC11 interacts with TAF15 to promote breast cancer progression via enhancing MAPK6 expression and activating the MAPK signaling pathway

Bin Wang, Hang Chen, Yumei Deng, Hong Chen, Lei Xing, Yuping Guo, Min Wang, Junxia Chen

Hypermethylation of ACADVL is involved in the high-intensity interval training-associated reduction of cardiac fibrosis in heart failure patients

Chih-Chin Hsu, Jong-Shyan Wang, Yu-Chiau Shyu, Tieh-Cheng Fu, Yu-Hsiang Juan, Shin-Sheng Yuan, Chao-Hung Wang, Chi-Hsiao Yeh, Po-Cheng Liao, Hsin-Yi Wu, Pang-Hung Hsu

Identification of Timm13 protein translocase of the mitochondrial inner membrane as a potential mediator of liver fibrosis based on bioinformatics and experimental verification

Xiaomin Liao, Xianxian Ruan, Xianbin Wu, Zhejun Deng, Shanyu Qin, Haixing Jiang

Multi-omics and experimental analysis unveil theragnostic value and immunological roles of inner membrane mitochondrial protein (IMMT) in breast cancer

Hung-Yu Lin, Hsing-Ju Wu, Pei-Yi Chu

Plasma gelsolin levels are associated with diabetes, sex, race, and poverty

Nicole Noren Hooten, Nicolle A. Mode, Edward Kowalik, Victor Omoniyi, Alan B. Zonderman, Ngozi Ezike, Mark J. DiNubile, Susan L. Levinson, Michele K. Evans

Constructing a novel mitochondrial-related gene signature for evaluating the tumor immune microenvironment and predicting survival in stomach adenocarcinoma

Jingjia Chang, Hao Wu, Jin Wu, Ming Liu, Wentao Zhang, Yanfen Hu, Xintong Zhang, Jing Xu, Li Li, Pengfei Yu, Jianjun Zhu

Lipid metabolism, BMI and the risk of nonalcoholic fatty liver disease in the general population: evidence from a mediation analysis

Song Lu, Qiyang Xie, Maobin Kuang, Chong Hu, Xinghui Li, Huijian Yang, Guotai Sheng, Guobo Xie, Yang Zou

Atf4 regulates angiogenic differences between alveolar bone and long bone macrophages by regulating M1 polarization, based on single-cell RNA sequencing, RNA-seq and ATAC-seq analysis

Lanxin Gu, Zhongyuan Wang, Hong Gu, Hua Wang, Luwei Liu, Wei-Bing Zhang

Tumor immune contexture predicts recurrence after prostatectomy and efficacy of androgen deprivation and immunotherapy in prostate cancer

Sujun Han, Taoping Shi, Yuchen Liao, Dong Chen, Feiya Yang, Mingshuai Wang, Jing Ma, Hu Li, Yu Xu, Tengfei Zhu, Wenxi Chen, Guoqiang Wang, Yusheng Han, Chunwei Xu, Wenxian Wang, Shangli Cai, Xu Zhang, Nianzeng Xing

Lactobacillus rhamnosus GG cell-free supernatant as a novel anti-cancer adjuvant

Rossella Salemi, Silvia Vivarelli, Daria Ricci, Marina Scillato, Maria Santagati, Giuseppe Gattuso, Luca Falzone, Massimo Libra

CCL5/CCR5-mediated peripheral inflammation exacerbates blood‒brain barrier disruption after intracerebral hemorrhage in mice

Jie Lin, Ya Xu, Peiwen Guo, Yù-Jié Chen, Jiru Zhou, Min Xia, Binbin Tan, Xin Liu, Hua Feng, Yujie Chen

Tuning CARs: recent advances in modulating chimeric antigen receptor (CAR) T cell activity for improved safety, efficacy, and flexibility

Piotr Celichowski, Marcello Turi, Sandra Charvátová, Dhwani Radhakrishnan, Neda Feizi, Zuzana Chyra, Michal Šimíček, Tomáš Jelínek, Juli Rodriguez Bago, Roman Hájek, Matouš Hrdinka

Gut microbiota mediated the individualized efficacy of Temozolomide via immunomodulation in glioma

Xiaoying Hou, Hongzhi Du, Yufei Deng, Haiping Wang, Jinmi Liu, Jialu Qiao, Wei Liu, Xiji Shu, Binlian Sun, Yuchen Liu

Increased circulating uric acid aggravates heart failure via impaired fatty acid metabolism

Bowen Lou, Haoyu Wu, Hannes Ott, Katrin Bennewitz, Chen Wang, Gernot Poschet, Hui Liu, Zuyi Yuan, Jens Kroll, Jianqing She

Grpel2 maintains cardiomyocyte survival in diabetic cardiomyopathy through DLST-mediated mitochondrial dysfunction: a proof-of-concept study

Rongjin Yang, Xiaomeng Zhang, Yunyun Zhang, Yingfan Wang, Man Li, Yuancui Meng, Jianbang Wang, Xue Wen, Jun Yu, Pan Chang

EGR1 induces EMT in pancreatic cancer via a P300/SNAI2 pathway

Yuanyang Wang, Cheng Qin, Bangbo Zhao, Zeru Li, Tianyu Li, Xiaoying Yang, Yutong Zhao, Weibin Wang

Tumor cell density dependent IL-8 secretion induces the fluctuation of tregs/CD8 + T cells infiltration in hepatocellular carcinoma: one prompt for the existence of density checkpoint

Mengchao Yan, Jia Yao, Yan Lin, Jun Yan, Ye Xie, Zongli Fu, Yongqiang Zhou, Jiayun Wei, Xun Li

Identification of FCN1 as a novel macrophage infiltration-associated biomarker for diagnosis of pediatric inflammatory bowel diseases

Xixi Chen, Yuanqi Gao, Jinfang Xie, Huiying Hua, Chun Pan, Jiebin Huang, Mengxia Jing, Xuehua Chen, Chundi Xu, Yujing Gao, Pu Li

An integrated approach of network pharmacology, molecular docking, and experimental verification uncovers kaempferol as the effective modulator of HSD17B1 for treatment of endometrial cancer

Guan-Yu Ruan, Li-Xiang Ye, Jian-Song Lin, Hong-Yu Lin, Li-Rui Yu, Cheng-Yan Wang, Xiao-Dan Mao, Shui-Hua Zhang, Peng-Ming Sun

iRGD-modified memory-like NK cells exhibit potent responses to hepatocellular carcinoma

Yanbing Dong, Ying Huang, Zhe Zhang, Aoxing Chen, Lin Li, Manman Tian, Jie Shen, Jie Shao

Multi-omics profiling of papillary thyroid microcarcinoma reveals different somatic mutations and a unique transcriptomic signature

Qiang Li, Tienan Feng, Tengteng Zhu, Weituo Zhang, Ying Qian, Huan Zhang, Xiangqian Zheng, Dapeng Li, Xinwei Yun, Jingzhu Zhao, Yangyang Li, Herbert Yu, Ming Gao, Biyun Qian

Correction: Uncovering the gene regulatory network of type 2 diabetes through multi-omic data integration

Jiachen Liu, Shenghua Liu, Zhaomei Yu, Xiaorui Qiu, Rundong Jiang, Weizheng Li

Identification of the MMP family as therapeutic targets and prognostic biomarkers in the microenvironment of head and neck squamous cell carcinoma

Maohua Liu, Lijuan Huang, Yunling Liu, Sen Yang, Yong Rao, Xiao Chen, Minhai Nie, Xuqian Liu

Transcriptomes of the tumor-adjacent normal tissues are more informative than tumors in predicting recurrence in colorectal cancer patients

Jinho Kim, Hyunjung Kim, Min-Seok Lee, Heetak Lee, Yeon Jeong Kim, Woo Yong Lee, Seong Hyeon Yun, Hee Cheol Kim, Hye Kyung Hong, Sridhar Hannenhalli, Yong Beom Cho, Donghyun Park, Sun Shim Choi

Immune profiling and prognostic model of pancreatic cancer using quantitative pathology and single-cell RNA sequencing

Kai Chen, Qi Wang, Xinxin Liu, Xiaodong Tian, Aimei Dong, Yinmo Yang

The oral microbiome in autoimmune diseases: friend or foe?

Xiaoyan Huang, Xiangyu Huang, Yi Huang, Jiarong Zheng, Ye Lu, Zizhao Mai, Xinyuan Zhao, Li Cui, Shaohong Huang

Role of OAS gene family in COVID-19 induced heart failure

Li-Juan Gao, Zhong-Mei He, Yi-Ying Li, Rui-Rui Yang, Min Yan, Xuan Shang, Ji-Min Cao

Safety and efficacy of co-administration of CD19 and CD22 CAR-T cells in children with B-ALL relapse after CD19 CAR-T therapy

Wenjie Li, Lixia Ding, Wenhua Shi, Xinyu Wan, Xiaomin Yang, Jing Yang, Tianyi Wang, Lili Song, Xiang Wang, Yani Ma, Chengjuan Luo, Jingyan Tang, Longjun Gu, Jing Chen, Jun Lu, Yanjing Tang, Benshang Li

CT-based deep learning model for the prediction of DNA mismatch repair deficient colorectal cancer: a diagnostic study

Wuteng Cao, Huabin Hu, Jirui Guo, Qiyuan Qin, Yanbang Lian, Jiao Li, Qianyu Wu, Junhong Chen, Xinhua Wang, Yanhong Deng

The Glioma-IRE project − Molecular profiling in patients with glioma: steps toward an individualized diagnostic and therapeutic approach

Veronica Villani, Beatrice Casini, Antonio Tanzilli, Mario Lecce, Fabrizio Rasile, Stefano Telera, Andrea Pace, Francesca Piludu, Irene Terrenato, Francesca Rollo, Francesca De Nicola, Maurizio Fanciulli, Matteo Pallocca, Gennaro Ciliberto, Mariantonia Carosi

Metabolically healthy obesity is associated with higher risk of both hyperfiltration and mildly reduced estimated glomerular filtration rate: the role of serum uric acid in a cross-sectional study

Hong Zhang, Rui Chen, Xiaohong Xu, Minxing Yang, Wenrong Xu, Shoukui Xiang, Long Wang, Xiaohong Jiang, Fei Hua, Xiaolin Huang

Exploring the putative role of PRDM1 and PRDM2 transcripts as mediators of T lymphocyte activation

Erika Di Zazzo, Monica Rienzo, Amelia Casamassimi, Caterina De Rosa, Nicola Medici, Patrizia Gazzerro, Maurizio Bifulco, Ciro Abbondanza

Mitochondrial ROS driven by NOX4 upregulation promotes hepatocellular carcinoma cell survival after incomplete radiofrequency ablation by inducing of mitophagy via Nrf2/PINK1

Chao Peng, Xi Li, Feng Ao, Ting Li, Jingpei Guo, Junfeng Liu, Xiaoting Zhang, Jinyan Gu, Junjie Mao, Bin Zhou

Mesenchymal stromal cells promote the drug resistance of gastrointestinal stromal tumors by activating the PI3K-AKT pathway via TGF-β2

Yu Zhao, Zuyi Weng, Xuan Zhou, Zhi Xu, Bei Cao, Bin Wang, Juan Li

PHF6 recruits BPTF to promote HIF-dependent pathway and progression in YAP-high breast cancer

Sheng Gao, Wensheng Zhang, Jingjing Ma, Xiaojian Ni

Prospective, longitudinal analysis of the gut microbiome in patients with locally advanced rectal cancer predicts response to neoadjuvant concurrent chemoradiotherapy

Yi Sun, Xiang Zhang, Chuandi Jin, Kaile Yue, Dashuang Sheng, Tao Zhang, Xue Dou, Jing Liu, Hongbiao Jing, Lei Zhang, Jinbo Yue

Tumor-targeted superantigens produce curative tumor immunity with induction of memory and demonstrated antigen spreading

Meir Azulay, Michal Shahar, Eitan Shany, Eti Elbaz, Sveta Lifshits, Marie Törngren, Adam Friedmann, Robert Kramer, Gunnar Hedlund

Comprehensive analysis of scRNA-Seq and bulk RNA-Seq reveals dynamic changes in the tumor immune microenvironment of bladder cancer and establishes a prognostic model

Zhiyong Tan, Xiaorong Chen, Jieming Zuo, Shi Fu, Haifeng Wang, Jiansong Wang

Cholesterol suppresses human iTreg differentiation and nTreg function through mitochondria-related mechanisms

Huanzhi Zhang, Ni Xia, Tingting Tang, Shaofang Nie, Lingfeng Zha, Min Zhang, Bingjie Lv, Yuzhi Lu, Jiao Jiao, Jingyong Li, Xiang Cheng

M1 polarization enhances the antitumor activity of chimeric antigen receptor macrophages in solid tumors

Yi Huo, Han Zhang, Longqi Sa, Wenjing Zheng, Yang He, Haohan Lyu, Mengjie Sun, Lingling Zhang, Lequn Shan, Angang Yang, Tao Wang

LMP2 deficiency causes abnormal metabolism, oxidative stress, neuroinflammation, myelin loss and neurobehavioral dysfunctions

Xingyong Chen, Yanguang Mao, Yueting Guo, Dongyun Xiao, Zejing Lin, Yiyi Huang, Ying Chun Liu, Xu Zhang, Yinzhou Wang

Mesenchymal stem cells can prevent or promote the progression of colon cancer based on their timing of administration

Weiqian Hu, Weijun Wang, Xin Jiang, Zeyu Wang, Rong Lin

Identification of transcription factors related to diabetic tubulointerstitial injury

Jialu Liu, Guangzhong Duan, Wenxia Yang, Shumin Zhang, Fuyou Liu, Youming Peng, Lin Sun, Yu Liu, Li Xiao

An integrated multi-omic approach demonstrates distinct molecular signatures between human obesity with and without metabolic complications: a case–control study

Fayaz Ahmad Mir, Raghvendra Mall, Ehsan Ullah, Ahmad Iskandarani, Farhan Cyprian, Tareq A. Samra, Meis Alkasem, Ibrahem Abdalhakam, Faisal Farooq, Shahrad Taheri, Abdul-Badi Abou-Samra

Klebsiella quasipneumoniae in intestine damages bile acid metabolism in hematopoietic stem cell transplantation patients with bloodstream infection

Guankun Yin, Yifan Guo, Qi Ding, Shuai Ma, Fengning Chen, Qi Wang, Hongbin Chen, Hui Wang

Microfat exerts an anti-fibrotic effect on human hypertrophic scar via fetuin-A/ETV4 axis

Qian Yu, Qiang Dai, Zonglin Huang, Chen Li, Li Yan, Xin Fu, Qian Wang, Yi Zhang, Lei Cai, Zhigang Yang, Ran Xiao

Analysis of circulating extracellular vesicle derived microRNAs in breast cancer patients with obesity: a potential role for Let-7a

Ines Barone, Luca Gelsomino, Felice Maria Accattatis, Francesca Giordano, Balazs Gyorffy, Salvatore Panza, Mario Giuliano, Bianca Maria Veneziani, Grazia Arpino, Carmine De Angelis, Pietro De Placido, Daniela Bonofiglio, Sebastiano Andò, Cinzia Giordano, Stefania Catalano

Intestinal barrier functions in hematologic and oncologic diseases

Elio Haroun, Prashanth Ashok Kumar, Ludovic Saba, Joseph Kassab, Krishna Ghimire, Dibyendu Dutta, Seah H. Lim

Correction: Tumor immunogenomic signatures improve a prognostic model of melanoma survival

Leah Morales, Danny Simpson, Robert Ferguson, John Cadley, Eduardo Esteva, Kelsey Monson, Vylyny Chat, Carlos Martinez, Jefrey Weber, Iman Osman, Tomas Kirchhof

Treatment with decitabine induces the expression of stemness markers, PD-L1 and NY-ESO-1 in colorectal cancer: potential for combined chemoimmunotherapy

Nassiba Taib, Maysaloun Merhi, Varghese Inchakalody, Sarra Mestiri, Shereena Hydrose, Karama Makni-Maalej, Afsheen Raza, Fairooz Sahir, Fouad Azizi, Parveen B. Nizamuddin, Queenie Fernandes, Zeenath Safira K. M. Yoosuf, Salam Almoghrabi, Lobna Al-Zaidan, Alaaeldin Shablak, Shahab Uddin, Cristina Maccalli, Mohammed Ussama Al Homsi, Said Dermime

The stromal-tumor amplifying STC1-Notch1 feedforward signal promotes the stemness of hepatocellular carcinoma

Shuya Bai, Yuchong Zhao, Wei Chen, Wang Peng, Yun Wang, Si Xiong, Aruna, Yanling Li, Yilei Yang, Shiru Chen, Bin Cheng, Ronghua Wang

Phase separation in cancer at a glance

Qingqing Xie, Jiejuan Cheng, Wuxuan Mei, Dexing Yang, Pengfei Zhang, Changchun Zeng

LncRNA H19-rich extracellular vesicles derived from gastric cancer stem cells facilitate tumorigenicity and metastasis via mediating intratumor communication network

Hongying Zhao, Rongke Jiang, Chunmei Zhang, Zhijing Feng, Xue Wang

Emerging healthy lifestyle factors and all-cause mortality among people with metabolic syndrome and metabolic syndrome-like characteristics in NHANES

Mengying Niu, Jiahao Chen, Rongyao Hou, Yu Sun, Qi Xiao, Xudong Pan, Xiaoyan Zhu

The roles of dietary lipids and lipidomics in gut-brain axis in type 2 diabetes mellitus

Duygu Ağagündüz, Mehmet Arif Icer, Ozge Yesildemir, Tevfik Koçak, Emine Kocyigit, Raffaele Capasso

Identification of serum exosomal metabolomic and proteomic profiles for remote ischemic preconditioning

Yang Du, Rui Qiu, Lei Chen, Yuewen Chen, Zhifeng Zhong, Peng Li, Fangcheng Fan, Yong Cheng

Natural killer cytotoxicity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a multi-site clinical assessment of ME/CFS (MCAM) sub-study

Troy D. Querec, Jin-Mann S. Lin, Yang Chen, Britany Helton, Andreas M. Kogelnik, Nancy G. Klimas, Daniel L. Peterson, Lucinda Bateman, Charles Lapp, Richard N. Podell, Benjamin H. Natelson, Elizabeth R. Unger, Elizabeth Unger, Jin-Mann Sally Lin, Monica Cornelius, Irina Dimulescu, Elizabeth Fall, Maung Khin, Mangalathu Rajeevan, Jennifer Bland, Patricia Jeys, Veronica Parkinson, Wendy Springs, Nancy Klimas, Elizabeth Balbin, Jeffry Cournoyer, Melissa Fernandez, Shuntae Parnell, Precious Leaks-Gutierrez, Benjamin Natelson, Michelle Blate, Gudrun Lange, Sarah Khan, Diana Vu, Andreas Kogelnik, Joan Danver, David Kaufman, Macy Pa, Catt Phan, Sophia Taleghani, Richard N Podell, Trisha Fitzpatrick, Beverly Licata, Daniel Peterson, Elena Lascu, Gunnar Gottschalk, Marco Maynard, Janet Smith

Correction: Muscle sodium content in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Elisabeth Petter, Carmen Scheibenbogen, Peter Linz, Christian Stehning, Klaus Wirth, Titus Kuehne, Marcus Kelm

Optimal timing and sequence of combining stereotactic radiosurgery with immune checkpoint inhibitors in treating brain metastases: clinical evidence and mechanistic basis

Wentao Tian, Xianjing Chu, Guilong Tanzhu, Rongrong Zhou

miRNA-seq identification and clinical validation of CD138+ and circulating miR-25 in treatment response of multiple myeloma

Maria-Alexandra Papadimitriou, Konstantinos Soureas, Aristea-Maria Papanota, Panagiotis Tsiakanikas, Panagiotis G. Adamopoulos, Ioannis Ntanasis-Stathopoulos, Panagiotis Malandrakis, Maria Gavriatopoulou, Diamantis C. Sideris, Efstathios Kastritis, Margaritis Avgeris, Meletios-Athanasios Dimopoulos, Evangelos Terpos, Andreas Scorilas

Altered cerebellar lobular volumes correlate with clinical deficits in siblings and children with ASD: evidence from toddlers

Manoj Kumar, Chandrakanta Hiremath, Sunil Kumar Khokhar, Eshita Bansal, Kommu John Vijay Sagar, Hansashree Padmanabha, Akhila S. Girimaji, Shweta Narayan, M. Thomas Kishore, B. K. Yamini, A. R. Jac Fredo, Jitender Saini, Rose Dawn Bharath

Modeling of clinical phenotypes in systemic lupus erythematosus based on the platelet transcriptome and FCGR2a genotype

MacIntosh G. Cornwell, Hanane El Bannoudi, Elliot Luttrell-Williams, Alexis Engel, Tessa J. Barrett, Khrystyna Myndzar, Peter Izmirly, H. Michael Belmont, Robert Clancy, Kelly V. Ruggles, Jill P. Buyon, Jeffrey S. Berger

Rocuronium bromide suppresses esophageal cancer via blocking the secretion of C–X–C motif chemokine ligand 12 from cancer associated fibroblasts

Jingyi Li, Xuefeng Gu, Guoqing Wan, Yuhan Wang, Kaijie Chen, Qi Chen, Changlian Lu

RETRACTED ARTICLE: Palmitoyl transferases act as novel drug targets for pancreatic cancer

Zhiqing Lin, Ziru Lv, Xin Liu, Keke Huang

Molecular fingerprints of nuclear genome and mitochondrial genome for early diagnosis of lung adenocarcinoma

Yichun Xu, Yong Yang, Yichao Wang, Jun Su, Tianlong Chan, Jiajing Zhou, Yi Gong, Ke Wang, Yifeng Gu, Congmeng Zhang, Guanjin Wu, Ling Bi, Xiong Qin, Junsong Han

SARS-CoV-2 before and after Omicron: two different viruses and two different diseases?

Renata Gili, Roberto Burioni

Association between metabolic syndrome components and gingival bleeding is women-specific: a nested cross-sectional study

Davide Pietropaoli, Serena Altamura, Eleonora Ortu, Luca Guerrini, Theresa T. Pizarro, Claudio Ferri, Rita Del Pinto

HIGD2A silencing impairs hepatocellular carcinoma growth via inhibiting mitochondrial function and the MAPK/ERK pathway

Kuiyuan Huang, Ziying Liu, Zhanglian Xie, Xiaoran Li, Haixing Zhang, Yu Chen, Yiran Wang, Zimo Lin, Chuanjiang Li, Hongyan Liu, Xiaoyong Zhang

Single-cell transcriptomics in ovarian cancer identify a metastasis-associated cell cluster overexpressed RAB13

Jiahao Guo, Xiaoyang Han, Jie Li, Zhefeng Li, Junjie Yi, Yan Gao, Xiaoting Zhao, Wentao Yue

FAP-targeted CAR-T suppresses MDSCs recruitment to improve the antitumor efficacy of claudin18.2-targeted CAR-T against pancreatic cancer

Yifan Liu, Yansha Sun, Peng Wang, Songling Li, Yiwei Dong, Min Zhou, Bizhi Shi, Hua Jiang, Ruixin Sun, Zonghai Li

Identification of novel cell-free RNAs in maternal plasma as preterm biomarkers in combination with placental RNA profiles

Heyue Jin, Yimin Zhang, Zhigang Fan, Xianyan Wang, Chen Rui, Shaozhen Xing, Hongmei Dong, Qunan Wang, Fangbiao Tao, Yumin Zhu

Cross-platform comparison of immune signatures in immunotherapy-treated patients with advanced melanoma using a rank-based scoring approach

Yizhe Mao, Tuba N. Gide, Nurudeen A. Adegoke, Camelia Quek, Nigel Maher, Alison Potter, Ellis Patrick, Robyn P. M. Saw, John F. Thompson, Andrew J. Spillane, Kerwin F. Shannon, Matteo S. Carlino, Serigne N. Lo, Alexander M. Menzies, Inês Pires da Silva, Georgina V. Long, Richard A. Scolyer, James S. Wilmott

Compensatory remodeling of a septo-hippocampal GABAergic network in the triple transgenic Alzheimer’s mouse model

Connor M Wander, Ya-Dong Li, Hechen Bao, Brent Asrican, Yan-Jia Luo, Heather A Sullivan, Tzu-Hao Harry Chao, Wei-Ting Zhang, Samantha L Chéry, Dalton S Tart, Ze-Ka Chen, Yen-Yu Ian Shih, Ian R Wickersham, Todd J Cohen, Juan Song

The interplay between androgens and the immune response in polycystic ovary syndrome

Sania Shabbir, Emaan Khurram, Vedhika Sathya Moorthi, Youssef Tamer Hassan Eissa, Mohammad Azhar Kamal, Alexandra E. Butler

Brevilin A is a potent anti-metastatic CRC agent that targets the VEGF-IL6-STAT3 axis in the HSCs-CRC interplay

Xueying Fan, Mingjing Meng, Baoting Li, Hui Chen, Jincheng Tan, Keyang Xu, Shilin Xiao, Hiu-Yee Kwan, Zhongqiu Liu, Tao Su

Phospholipase A2 regulates autophagy in gouty arthritis: proteomic and metabolomic studies

Weili Fu, Minghao Ge, Jian Li

Protective properties of extracellular vesicles in sepsis models: a systematic review and meta-analysis of preclinical studies

Shujun Yang, Kanglong Zhang, Jingyu Hou, Xin Liu, Daishi Xu, Xuxiang Chen, Shuangmei Li, Yinghui Hong, Changqing Zhou, Hao Wu, Guanghui Zheng, Chaotao Zeng, Haidong Wu, Jiaying Fu, Tong Wang

The convergent application of metabolites from Avena sativa and gut microbiota to ameliorate non-alcoholic fatty liver disease: a network pharmacology study

Ki-Kwang Oh, Sang-Jun Yoon, Su-Been Lee, Sang Youn Lee, Haripriya Gupta, Raja Ganesan, Satya Priya Sharma, Sung-Min Won, Jin-Ju Jeong, Dong Joon Kim, Ki-Tae Suk

Microbiota-derived tryptophan metabolites indole-3-lactic acid is associated with intestinal ischemia/reperfusion injury via positive regulation of YAP and Nrf2

Fang-Ling Zhang, Xiao-Wei Chen, Yi-Fan Wang, Zhen Hu, Wen-Juan Zhang, Bo-Wei Zhou, Peng-Fei Ci, Ke-Xuan Liu

The “Great Debate” at Melanoma Bridge 2022, Naples, December 1st–3rd, 2022

Paolo A. Ascierto, Christian Blank, Alexander M. Eggermont, Claus Garbe, Jeffrey E. Gershenwald, Omid Hamid, Axel Hauschild, Jason J. Luke, Janice M. Mehnert, Jeffrey A. Sosman, Hussein A. Tawbi, Mario Mandalà, Alessandro Testori, Corrado Caracò, Iman Osman, Igor Puzanov

Integrated microbiome and metabolome analysis reveals novel urinary microenvironmental signatures in interstitial cystitis/bladder pain syndrome patients

Zhenming Zheng, Jintao Hu, Wenshuang Li, Kaiqun Ma, Caixia Zhang, Kuiqing Li, Yousheng Yao

Mesenchymal–epithelial transition in lymph node metastases of oral squamous cell carcinoma is accompanied by ZEB1 expression

Kai Horny, Christoph Sproll, Lukas Peiffer, Frauke Furtmann, Patricia Gerhardt, Jan Gravemeyer, Nikolas H. Stoecklein, Ivelina Spassova, Jürgen C. Becker

Correction: Molecular fingerprints of nuclear genome and mitochondrial genome for early diagnosis of lung adenocarcinoma

Yichun Xu, Yong Yang, Yichao Wang, Jun Su, Tianlong Chan, Jiajing Zhou, Yi Gong, Ke Wang, Yifeng Gu, Congmeng Zhang, Guanjin Wu, Ling Bi, Xiong Qin, Junsong Han

Can the ChatGPT and other large language models with internet-connected database solve the questions and concerns of patient with prostate cancer and help democratize medical knowledge?

Lingxuan Zhu, Weiming Mou, Rui Chen

Size matters: the impact of nucleus size on results from spatial transcriptomics

Elyas Mohammadi, Katarzyna Chojnowska, Michał Bieńkowski, Anna Kostecka, Magdalena Koczkowska, Michał A. Żmijewski, Marcin Jąkalski, Martin Ingelsson, Natalia Filipowicz, Paweł Olszewski, Hanna Davies, Justyna M. Wierzbicka, Bradley T. Hyman, Jan P. Dumanski, Arkadiusz Piotrowski, Jakub Mieczkowski

Blockade of CCR4 breaks immune tolerance in chronic hepatitis B patients by modulating regulatory pathways

Arshi Khanam, Alip Ghosh, Joel V. Chua, Shyam Kottilil

Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants

Silvia Alemany, María Soler-Artigas, Judit Cabana-Domínguez, Dana Fakhreddine, Natalia Llonga, Laura Vilar-Ribó, Amanda Rodríguez-Urrutia, Judit Palacio, Ana María González-Castro, Beatriz Lobo, Carmen Alonso-Cotoner, Magnus Simrén, Javier Santos, Josep Antoni Ramos-Quiroga, Marta Ribasés

Spontaneous cancer remission after COVID-19: insights from the pandemic and their relevance for cancer treatment

Concetta Meo, Giuseppe Palma, Francesca Bruzzese, Alfredo Budillon, Claudio Napoli, Filomena de Nigris

Analogies between the periphery of cancer and the leading edge of pulmonary fibrosis

Monica Pernia Marin, Mary Salvatore

The “Great Debate” at Immunotherapy Bridge 2022, Naples, November 30th–December 1st, 2022

Paolo A. Ascierto, Renier Brentjens, Samir N. Khleif, Kunle Odunsi, Katayoun Rezvani, Marco Ruella, Ryan J. Sullivan, Bernard A. Fox, Igor Puzanov

The activation of mTOR signalling modulates DNA methylation by enhancing DNMT1 translation in hepatocellular carcinoma

Mengke Chen, Yi Fang, Meinong Liang, Ning Zhang, Xinyue Zhang, Lixia Xu, Xuxin Ren, Qingfeng Zhang, Yufeng Zhou, Sui Peng, Jun Yu, Judeng Zeng, Xiaoxing Li

Anti-Alzheimers molecular mechanism of icariin: insights from gut microbiota, metabolomics, and network pharmacology

Yuqing Liu, Hongli Li, Xiaowei Wang, Jianhua Huang, Di Zhao, Yejun Tan, Zheyu Zhang, Zhen Zhang, Lemei Zhu, Beibei Wu, Zhibao Chen, Weijun Peng

Comprehensive single-cell transcriptomic and proteomic analysis reveals NK cell exhaustion and unique tumor cell evolutionary trajectory in non-keratinizing nasopharyngeal carcinoma

Cuimin Chen, Chun Wang, Ruifang Pang, Huanyu Liu, Weihua Yin, Jiakang Chen, Lili Tao

A dominant variant in apoptosis-related gene XKR8 is relevant to hereditary auditory neuropathy

Kaitian Chen, Changwu Li, Chang Dong, Xiaoqing Cen, Yueying Wang, Yue Liang, Yuanping Zhu, Shubin Fang, Hongyan Jiang

Association of oily fish and nonoily fish intakes with all-cause mortality and cause-specific mortality: a large population-based prospective study

Jian Zhou, Xiankui Tan, Yihan Li, Rongjun Wan, Ziyi Wu, Zhengjun Lin, Wanchun Wang, Yingquan Luo, Tang Liu

STIL/AURKA axis promotes cell proliferation by influencing primary cilia formation in bladder cancer

Jingxian Li, Yuanjiong Qi, Bo Li, Yan Liu, Kuo Yang, Zhihong Zhang, Jianqiang Zhu, E. Du

A tumor focused approach to resolving the etiology of DNA mismatch repair deficient tumors classified as suspected Lynch syndrome

Romy Walker, Khalid Mahmood, Jihoon E. Joo, Mark Clendenning, Peter Georgeson, Julia Como, Sharelle Joseland, Susan G. Preston, Yoland Antill, Rachel Austin, Alex Boussioutas, Michelle Bowman, Jo Burke, Ainsley Campbell, Simin Daneshvar, Emma Edwards, Margaret Gleeson, Annabel Goodwin, Marion T. Harris, Alex Henderson, Megan Higgins, John L. Hopper, Ryan A. Hutchinson, Emilia Ip, Joanne Isbister, Kais Kasem, Helen Marfan, Di Milnes, Annabelle Ng, Cassandra Nichols, Shona O’Connell, Nicholas Pachter, Bernard J. Pope, Nicola Poplawski, Abiramy Ragunathan, Courtney Smyth, Allan Spigelman, Kirsty Storey, Rachel Susman, Jessica A. Taylor, Linda Warwick, Mathilda Wilding, Rachel Williams, Aung K. Win, Michael D. Walsh, Finlay A. Macrae, Mark A. Jenkins, Christophe Rosty, Ingrid M. Winship, Daniel D. Buchanan

Taxonomic reclassification of Kaposi Sarcoma identifies disease entities with distinct immunopathogenesis

M. R. Openshaw, E. Gervasi, C. A. M. Fulgenzi, D. J. Pinato, A. Dalla Pria, M. Bower

The relationship between micronutrient status, frailty, systemic inflammation, and clinical outcomes in patients admitted to hospital with COVID-19

Josh McGovern, John Wadsworth, Anthony Catchpole, Conor Richards, Donald C. McMillan, Tadhg Kelliher, Emma Goodall, Ellie Murray, Terry Melaugh, Shannon McPhillips, Kathryn Brice, Katie Barbour, Sophie Robinson, Peter Moffitt, Olivia Kemp, Dinesh Talwar, Donogh Maguire

The intratumour microbiota and neutrophilic inflammation in squamous cell vulvar carcinoma microenvironment

Natalia Rustetska, Magdalena Szczepaniak, Krzysztof Goryca, Elwira Bakuła-Zalewska, Małgorzata Figat, Artur Kowalik, Stanisław Góźdź, Magdalena Kowalewska

Ubiquitin specific peptidase 37 and PCNA interaction promotes osteosarcoma pathogenesis by modulating replication fork progression

Ravi Chauhan, Ashna Gupta, Lakshay Malhotra, Ajaz A. Bhat, Raj K. Pandita, Tariq Masoodi, Gunjan Dagar, Hana Q. Sadida, Sara K. Al-Marzooqi, Atul Batra, Sameer Bakhshi, Mehar Chand Sharma, Pranay Tanwar, Shah Alam Khan, Ethayathulla Abdul Samath, Shahab Uddin, Ammira S. Al-Shabeeb Akil, Mohammad Haris, Muzafar A. Macha, Tej K. Pandita, Mayank Singh

Validation of multiparametric MRI based prediction model in identification of pseudoprogression in glioblastomas

Laiz Laura de Godoy, Suyash Mohan, Sumei Wang, MacLean P. Nasrallah, Yu Sakai, Donald M. O’Rourke, Stephen Bagley, Arati Desai, Laurie A. Loevner, Harish Poptani, Sanjeev Chawla

Circular RNA EPHA3 suppresses progression and metastasis in prostate cancer through the miR-513a-3p/BMP2 axis

Huan Feng, Zhiyao Deng, Wei Peng, Xian Wei, Jihong Liu, Tao Wang

Correction: Mechanistically informed non-invasive peripheral nerve stimulation for peripheral neuropathic pain: a randomised double-blind sham-controlled trial

Selina Johnson, Anne Marshall, Dyfrig Hughes, Emily Holmes, Florian Henrich, Turo Nurmikko, Manohar Sharma, Bernhard Frank, Paul Bassett, Andrew Marshall, Walter Magerl, Andreas Goebel

OSMR deficiency aggravates pressure overload-induced cardiac hypertrophy by modulating macrophages and OSM/LIFR/STAT3 signalling

Yizhou Feng, Yuan Yuan, Hongxia Xia, Zhaopeng Wang, Yan Che, Zhefu Hu, Jiangyang Deng, Fangfang Li, Qingqing Wu, Zhouyan Bian, Heng Zhou, Difei Shen, Qizhu Tang

Correction: Precision information extraction for rare disease epidemiology at scale

William Z. Kariampuzha, Gioconda Alyea, Sue Qu, Jaleal Sanjak, Ewy Mathé, Eric Sid, Haley Chatelaine, Arjun Yadaw, Yanji Xu, Qian Zhu

Strengths and limitations of new artificial intelligence tool for rare disease epidemiology

David Lapidus

Protectin conjugates in tissue regeneration 1 alleviates sepsis-induced acute lung injury by inhibiting ferroptosis

Ya Lv, Deming Chen, Xinyi Tian, Ji Xiao, Congcong Xu, Linan Du, Jiacong Li, Siyu Zhou, Yuxiang Chen, Rong Zhuang, Yuqiang Gong, Binyu Ying, Fang Gao-Smith, Shengwei Jin, Ye Gao

Mitochondria-derived vesicles and their potential roles in kidney stone disease

Sakdithep Chaiyarit, Visith Thongboonkerd

Preventative effect of TSPO ligands on mixed antibody-mediated rejection through a Mitochondria-mediated metabolic disorder

Yannan Zhang, Jiannan He, Zhe Yang, Haofeng Zheng, Haoxiang Deng, Zihuan Luo, Qipeng Sun, Qiquan Sun

Genomic alterations of cerebrospinal fluid cell-free DNA in leptomeningeal metastases of gastric cancer

Xin Chen, Kaixuan Bai, Yu Zhang, Yang Xu, Yinghao Huo, Sha Wang, Yueli Zou, Xuejiao Qi, Rongyun Guo, Qiuxiang Ou, Dengxiang Liu, Shaohua Yin, Shubo Chen, Hui Bu

Neuropilin-1 promotes mitochondrial structural repair and functional recovery in rats with cerebral ischemia

Ting Guo, Manli Chen, Ji Liu, Zengyu Wei, Jinjin Yuan, Wenwen Wu, Zhiyun Wu, Yongxing Lai, Zijun Zhao, Hongbin Chen, Nan Liu

The potential crosstalk between tumor and plasma cells and its association with clinical outcome and immunotherapy response in bladder cancer

Fei Long, Wei Wang, Shuo Li, Bicheng Wang, Xin Hu, Jun Wang, Yaqi Xu, Min Liu, Junting Zhou, Huaqi Si, Xiaodan Xi, Xiang-yu Meng, Chunhui Yuan, Fubing Wang

Assessing temporal differences in the predictive power of baseline TyG-related parameters for future diabetes: an analysis using time-dependent receiver operating characteristics

Maobin Kuang, Ruijuan Yang, Xin Huang, Chao Wang, Guotai Sheng, Guobo Xie, Yang Zou

Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease

Chuyun Yan, Wanting Hu, Jinqi Tu, Jinyao Li, Qionglin Liang, Shuxin Han

A Pronectin™ AXL-targeted first-in-class bispecific T cell engager (pAXLxCD3ε) for ovarian cancer

Caterina Riillo, Nicoletta Polerà, Maria Teresa Di Martino, Giada Juli, Craig A. Hokanson, Tatjana Odineca, Stefania Signorelli, Katia Grillone, Serena Ascrizzi, Antonia Mancuso, Nicoletta Staropoli, Basilio Caparello, Maria Cerra, Giuseppe Nisticò, Pierosandro Tagliaferri, Roberto Crea, Daniele Caracciolo, Pierfrancesco Tassone

Disheveled3 enhanced EMT and cancer stem-like cells properties via Wnt/β-catenin/c-Myc/SOX2 pathway in colorectal cancer

Zhengguang Li, Zhirong Yang, Wei Liu, Wanglong Zhu, Lan Yin, Zhenyu Han, Yu Xian, Jie Wen, Hualong Tang, Xinyue Lin, Yuhan Yang, Jingyi Wang, Kun Zhang

SYTL2 promotes metastasis of prostate cancer cells by enhancing FSCN1-mediated pseudopodia formation and invasion

Zean Li, Yiran Tao, Ze Gao, Shirong Peng, Yiming Lai, Kaiwen Li, Xu Chen, Hai Huang

Correction: Transcriptomes of the tumor-adjacent normal tissues are more informative than tumors in predicting recurrence in colorectal cancer patients

Jinho Kim, Hyunjung Kim, Min‑Seok Lee, Heetak Lee, Yeon Jeong Kim, Woo Yong Lee, Seong Hyeon Yun, Hee Cheol Kim, Hye Kyung Hong, Sridhar Hannenhalli, Yong Beom Cho, Donghyun Park, Sun Shim Choi

Benefits of applying molecular barcoding systems are not uniform across different genomic applications

Jonathan Bieler, Slawomir Kubik, Morgane Macheret, Christian Pozzorini, Adrian Willig, Zhenyu Xu

The oncogenic role of NF1 in gallbladder cancer through regulation of YAP1 stability by direct interaction with YAP1

Lingxiao Zhang, Lin Jiang, Ling Zeng, Zhaohui Jin, Xuanjia Dong, Yuhan Zhang, Litian Chen, Yijun Shu, Yingbin Liu, Ying Huang

Sp1 promotes tumour progression by remodelling the mitochondrial network in cervical cancer

Xu Xu, Xiaona Wang, Qihui Chen, Aman Zheng, Donglu Li, Ziqi Meng, Xinran Li, Hanchen Cai, Wangzhi Li, Shiyuan Huang, Fan Wang

Infantile hemangioma models: is the needle in a haystack?

Meng Kong, Yanan Li, Kai Wang, Shisong Zhang, Yi Ji

MicroRNA-143 acts as a tumor suppressor through Musashi-2/DLL1/Notch1 and Musashi-2/Snail1/MMPs axes in acute myeloid leukemia

Fanfan Li, Yixiang Han, Rongrong Chen, Yinyan Jiang, Cheng Chen, Xiaofang Wang, Jifan Zhou, Qingqing Xu, Songfu Jiang, Si Zhang, Kang Yu, Shenghui Zhang

Detection of mild cognitive impairment in Parkinson’s disease using gradient boosting decision tree models based on multilevel DTI indices

Boyu Chen, Ming Xu, Hongmei Yu, Jiachuan He, Yingmei Li, Dandan Song, Guo Guang Fan

Correction: iRGD-modified memory-like NK cells exhibit potent responses to hepatocellular carcinoma

Yanbing Dong, Ying Huang, Zhe Zhang, Aoxing Chen, Lin Li, Manman Tian, Jie Shen, Jie Shao

Retraction Note: Circular RNA hsa_circ_0055538 regulates the malignant biological behavior of oral squamous cell carcinoma through the p53/Bcl-2/caspase signaling pathway

Wen Su, Shuai Sun, Feng Wang, Yuehong Shen, Hongyu Yang

Cardiomyocyte-targeting exosomes from sulforaphane-treated fibroblasts affords cardioprotection in infarcted rats

Gaia Papini, Giulia Furini, Marco Matteucci, Vanessa Biemmi, Valentina Casieri, Nicole Di Lascio, Giuseppina Milano, Lucia Rosa Chincoli, Francesco Faita, Lucio Barile, Vincenzo Lionetti

P21 facilitates macrophage chemotaxis by promoting CCL7 in the lung epithelial cell lines treated with radiation and bleomycin

Xinglong Liu, Liang Zeng, Yuchuan Zhou, Xinrui Zhao, Lin Zhu, Jianghong Zhang, Yan Pan, Chunlin Shao, Jiamei Fu

Correction: Correlations between cytoplasmic CSE1L in neoplastic colorectal glands and depth of tumor penetration and cancer stage

Cheng-Jeng Tai, Tzu-Cheng Su, Ming-Chung Jiang, Hung-Chang Chen, Shing-Chuan Shen, Woan-Ruoh Lee, Ching-Fong Liao, Ying-Chun Chen, Shu-Hui Lin, Li-Tzu Li, Ko-Hung Shen, Chung-Min Yeh, Kun-Tu Yeh, Ching-Hsiao Lee, Hsin-Yi Shih, Chun-Chao Chang

Gut microbiome combined with metabolomics reveals biomarkers and pathways in central precocious puberty

Xiaoyan Huang, Jixiong Chen, Haozhe Zou, Peng Huang, Hailing Luo, Haidan Li, Yuhua Cai, Li Liu, Yongsheng Li, Xiaojie He, Wei Xiang

Human pancreatic cancer patients with Epithelial-to-Mesenchymal Transition and an aggressive phenotype show a disturbed balance in Protein Phosphatase Type 2A expression and functionality

Jos van Pelt, Bob Meeusen, Rita Derua, Liesbeth Guffens, Eric Van Cutsem, Veerle Janssens, Chris Verslype

Potential clinical implications of CD4+CD26high T cells for nivolumab treated melanoma patients

Domenico Galati, Serena Zanotta, Mariaelena Capone, Gabriele Madonna, Domenico Mallardo, Marilena Romanelli, Ester Simeone, Lucia Festino, Francesca Sparano, Rosa Azzaro, Rosaria De Filippi, Antonio Pinto, Chrystal M. Paulos, Paolo A. Ascierto

The serum proteome of VA-ECMO patients changes over time and allows differentiation of survivors and non-survivors: an observational study

Patrick Malcolm Siegel, Bálint András Barta, Lukas Orlean, Ines Derya Steenbuck, Miguel Cosenza-Contreras, Tobias Wengenmayer, Georg Trummer, Dennis Wolf, Dirk Westermann, Oliver Schilling, Philipp Diehl

Functional status and spatial architecture of tumor-infiltrating CD8+ T cells are associated with lymph node metastases in non-small cell lung cancer

Guanqun Yang, Siqi Cai, Mengyu Hu, Chaozhuo Li, Liying Yang, Wei Zhang, Jujie Sun, Fenghao Sun, Ligang Xing, Xiaorong Sun

LINC00963-FOSB-mediated transcription activation of UBE3C enhances radioresistance of breast cancer cells by inducing ubiquitination-dependent protein degradation of TP73

Yansu Wang, Ming Liu, Xiaoqian Liu, Xianling Guo

Proteomics and cytokine analyses distinguish myalgic encephalomyelitis/chronic fatigue syndrome cases from controls

Ludovic Giloteaux, Jiayin Li, Mady Hornig, W. Ian Lipkin, David Ruppert, Maureen R. Hanson

The PI3K-Akt-mTOR pathway mediates renal pericyte-myofibroblast transition by enhancing glycolysis through HKII

Liangmei Chen, Xiaofan Li, Yiyao Deng, Jianwen Chen, Mengjie Huang, Fengge Zhu, Zhumei Gao, Lingling Wu, Quan Hong, Zhe Feng, Guangyan Cai, Xuefeng Sun, Xueyuan Bai, Xiangmei Chen

A novel Chr1-miR-200 driven whole transcriptome signature shapes tumor immune microenvironment and predicts relapse in early-stage lung adenocarcinoma

Simon Garinet, Audrey Didelot, Laetitia Marisa, Guillaume Beinse, Marine Sroussi, Françoise Le Pimpec-Barthes, Elizabeth Fabre, Laure Gibault, Pierre Laurent-Puig, Sophie Mouillet-Richard, Antoine Legras, Hélène Blons

MiR-146a rs2910164 (G/C) polymorphism is associated with the development and prognosis of acute coronary syndromes: an observational study including case control and validation cohort

Xiang-Rui Qiao, Tao Zheng, Yifei Xie, Xinyi yao, Zuyi Yuan, Yue Wu, Dong Zhou, Tao Chen

SDMA attenuates renal tubulointerstitial fibrosis through inhibition of STAT4

Yanzhe Wang, Ming Wu, Dongping Chen, Bo Tan, Pinglan Lin, Di Huang, Chaoyang Ye

Alterations in the microenvironment and the effects produced of TRPV5 in osteoporosis

Zhi-heng Luo, Jian-xiong Ma, Wei Zhang, Ai-xian Tian, Shu-wei Gong, Yan Li, Yu-xiao Lai, Xin-long Ma

Mitochondrial impairment and downregulation of Drp1 phosphorylation underlie the antiproliferative and proapoptotic effects of alantolactone on oral squamous cell carcinoma cells

Yafei Zhang, Bingqian Yang, Chengwei Tu, Yifan Ping, Shuhong Chen, Tong Wu, Zheyu Zhao, Yixin Mao, Zhan Yang, Zelin Cao, Jianmin Li, Kate Huang, Xi Ding, Gang Wu, Peng Zou, Zhennan Deng, Xiaoyu Sun

Haploidentical transplants deliver equal outcomes to matched sibling transplants: a propensity score-matched analysis

Hengwei Wu, Yeqian Zhao, Fei Gao, Jimin Shi, Yi Luo, Jian Yu, Xiaoyu Lai, Lizhen Liu, Huarui Fu, Pengxu Qian, He Huang, Yanmin Zhao

Advances in spatial transcriptomics and related data analysis strategies

Jun Du, Yu-Chen Yang, Zhi-Jie An, Ming-Hui Zhang, Xue-Hang Fu, Zou-Fang Huang, Ye Yuan, Jian Hou

Inflammatory and interferon gene expression signatures in patients with mitochondrial disease

Emily B. Warren, Eliza M. Gordon-Lipkin, Foo Cheung, Jinguo Chen, Amrita Mukherjee, Richard Apps, John S. Tsang, Jillian Jetmore, Melissa L. Schlein, Shannon Kruk, Yuanjiu Lei, A. Phillip West, Peter J. McGuire

Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer’s disease patients

Abdulahad Bayraktar, Xiangyu Li, Woonghee Kim, Cheng Zhang, Hasan Turkez, Saeed Shoaie, Adil Mardinoglu

SARS-CoV-2 Omicron infection, who will be developed into severe/critical diseases?

Mudan Feng, Qing Lin, Jian Xu

CEBPG suppresses ferroptosis through transcriptional control of SLC7A11 in ovarian cancer

Xiaoqian Zhang, Xiaocui Zheng, Xiang Ying, Weiwei Xie, Yujia Yin, Xipeng Wang

IL-17A-mediated mitochondrial dysfunction induces pyroptosis in colorectal cancer cells and promotes CD8 + T-cell tumour infiltration

Wen-Qing Feng, Yu-Chen Zhang, Zhuo-Qing Xu, Su-Yue Yu, Jian-ting Huo, Abudumaimaitijiang Tuersun, Min-Hua Zheng, Jing-Kun Zhao, Ya-Ping Zong, Ai-Guo Lu

Get this thing out of my body! Factors determining consent for translational oncology research: a qualitative research

Desprès Caroline, Mamzer Marie-France

Noninvasive prediction of node-positive breast cancer response to presurgical neoadjuvant chemotherapy therapy based on machine learning of axillary lymph node ultrasound

Hao Zhang, Wen Cao, Lianjuan Liu, Zifan Meng, Ningning Sun, Yuanyuan Meng, Jie Fei

Predicting response and toxicity to immune checkpoint inhibitors in lung cancer using antibodies to frameshift neoantigens

Luhui Shen, Justin R. Brown, Stephen Albert Johnston, Mehmet Altan, Kathryn F. Sykes

Expression pattern analysis of m6A regulators reveals IGF2BP3 as a key modulator in osteoarthritis synovial macrophages

Yuheng Lu, Hongbo Zhang, Haoyan Pan, Zhicheng Zhang, Hua Zeng, Haoyu Xie, Jianbin Yin, Wen Tang, Rengui Lin, Chun Zeng, Daozhang Cai

Targeting unfolded protein response reverts ER stress and ER Ca2+ homeostasis in cardiomyocytes expressing the pathogenic variant of Lamin A/C R321X

Giusy Pietrafesa, Roberta De Zio, Simona Ida Scorza, Maria Francesca Armentano, Martino Pepe, Cinzia Forleo, Giuseppe Procino, Andrea Gerbino, Maria Svelto, Monica Carmosino

ISG15 targets glycosylated PD-L1 and promotes its degradation to enhance antitumor immune effects in lung adenocarcinoma

Tongyuan Qu, Wenshuai Zhang, Chenhui Yan, Danyang Ren, Yalei Wang, Yuhong Guo, Qianru Guo, Jinpeng Wang, Liren Liu, Lei Han, Lingmei Li, Qiujuan Huang, Lu Cao, Zhaoxiang Ye, Bin Zhang, Qiang Zhao, Wenfeng Cao

The Swedish childhood tumor biobank: systematic collection and molecular characterization of all pediatric CNS and other solid tumors in Sweden

Teresita Díaz de Ståhl, Alia Shamikh, Markus Mayrhofer, Szilvester Juhos, Elisa Basmaci, Gabriela Prochazka, Maxime Garcia, Praveen Raj Somarajan, Katarzyna Zielinska-Chomej, Christopher Illies, Ingrid Øra, Peter Siesjö, Per-Erik Sandström, Jakob Stenman, Magnus Sabel, Bengt Gustavsson, Per Kogner, Susan Pfeifer, Gustaf Ljungman, Johanna Sandgren, Monica Nistér

Fatty acids metabolism affects the therapeutic effect of anti-PD-1/PD-L1 in tumor immune microenvironment in clear cell renal cell carcinoma

Hansen Lin, Liangmin Fu, Pengju Li, Jiangquan Zhu, Quanhui Xu, Yinghan Wang, Mukhtar Adan Mumin, Xinwei Zhou, Yuhang Chen, Guannan Shu, Gaosheng Yao, Minyu Chen, Jun Lu, Lizhen Zhang, YuJun Liu, Yiqi Zhao, Jiahao Bao, Wei Chen, Junhang Luo, Xiaofei Li, Zhenhua Chen, Jiazheng Cao

Validation of circulating histone detection by mass spectrometry for early diagnosis, prognosis, and management of critically ill septic patients

José Luis García-Giménez, Eva García-López, Salvador Mena-Mollá, Jesús Beltrán-García, Rebeca Osca-Verdegal, Elena Nacher-Sendra, Carmen Aguado-Velasco, Germán Casabó-Vallés, Carlos Romá-Mateo, María Rodriguez-Gimillo, Oreto Antúnez, José Ferreres, Federico V. Pallardó, Nieves Carbonell

The role of mitochondria in the resistance of melanoma to PD-1 inhibitors

Fei Du, Lu-han Yang, Jiao Liu, Jian Wang, Lianpeng Fan, Suwit Duangmano, Hao Liu, Minghua Liu, Jun Wang, Xiaolin Zhong, Zhuo Zhang, Fang Wang

A bispecific antibody AP203 targeting PD-L1 and CD137 exerts potent antitumor activity without toxicity

Po-Lin Huang, Hung-Tsai Kan, Ching-Hsuan Hsu, Hsin-Ta Hsieh, Wan-Chien Cheng, Ren-Yeong Huang, Jhong-Jhe You

Mitochondrial transplantation as a novel therapeutic strategy for cardiovascular diseases

Mingchu Sun, Wenhua Jiang, Nan Mu, Zihui Zhang, Lu Yu, Heng Ma

Targeting severe symptoms of early 2023-new outbreak of COVID-19 by classical drug dexamethasone: a potential fatality reducing agent

Dongsheng Liu, Aamir Saeed, Sidra Majaz, Bashrat Ahmad, Ashfaq Ahmad, Yingqiu Xie

Effect of the gut microbiota and their metabolites on postoperative intestinal motility and its underlying mechanisms

TianRong Ma, XiaoLei Xue, Hui Tian, XinXiu Zhou, JunKe Wang, ZhiWen Zhao, MingFei Wang, JiYuan Song, RenXiang Feng, Leping Li, Changqing Jing, Feng Tian

Suicide gene therapy using allogeneic adipose tissue-derived mesenchymal stem cell gene delivery vehicles in recurrent glioblastoma multiforme: a first-in-human, dose-escalation, phase I clinical trial

Saeed Oraee-Yazdani, Roozbeh Tavanaei, Fatemeh Rostami, Atieh Hajarizadeh, Marzieh Mehrabadi, Mohammadhosein Akhlaghpasand, Mona Tamaddon, Samin Khannejad, Kaveh Oraii Yazdani, Alireza Zali

Biometals in Alzheimer disease: emerging therapeutic and diagnostic potential of molybdenum and iodine

Benson O. A. Botchway, Xuehong Liu, Yu Zhou, Marong Fang

Cerebellar connectome alterations and associated genetic signatures in multiple sclerosis and neuromyelitis optica spectrum disorder

Yuping Yang, Junle Li, Ting Li, Zhen Li, Zhizheng Zhuo, Xuemei Han, Yunyun Duan, Guanmei Cao, Fenglian Zheng, Decai Tian, Xinli Wang, Xinghu Zhang, Kuncheng Li, Fuqing Zhou, Muhua Huang, Yuxin Li, Haiqing Li, Yongmei Li, Chun Zeng, Ningnannan Zhang, Jie Sun, Chunshui Yu, Fudong Shi, Umer Asgher, Nils Muhlert, Yaou Liu, Jinhui Wang

Development and validation of explainable machine-learning models for carotid atherosclerosis early screening

Ke Yun, Tao He, Shi Zhen, Meihui Quan, Xiaotao Yang, Dongliang Man, Shuang Zhang, Wei Wang, Xiaoxu Han

Association between lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide in a Norwegian population-based adult cohort

Maryia Khomich, Huang Lin, Andrei Malinovschi, Susanne Brix, Lucia Cestelli, Shyamal Peddada, Ane Johannessen, Carsten Eriksen, Francisco Gomez Real, Cecilie Svanes, Randi Jacobsen Bertelsen

Ideal vitamin D and handgrip strength counteracts the risk effect of APOE genotype on dementia: a population-based longitudinal study

Jiangtao Feng, Qi Wang, Yuan Zhang

Circular RNA circ0001955 promotes cervical cancer tumorigenesis and metastasis via the miR-188-3p/NCAPG2 axis

Wei Wang, Haixia Luo, Jingjing Chang, Xin Yang, Xiu Zhang, Qingmei Zhang, Yuanxing Li, Yueyang Zhao, Jianbing Liu, Binbin Zou, Min Hao

Causality of genetically determined metabolites and metabolic pathways on osteoarthritis: a two-sample mendelian randomization study

Yifei Gu, Qianmei Jin, Jinquan Hu, Xinwei Wang, Wenchao Yu, Zhanchao Wang, Chen Wang, Yang Liu, Yu Chen, Wen Yuan

Single-cell analysis of adult human heart across healthy and cardiovascular disease patients reveals the cellular landscape underlying SARS-CoV-2 invasion of myocardial tissue through ACE2

Cong Chen, Jie Wang, Yong-Mei Liu, Jun Hu

Screening of immune-related secretory proteins linking chronic kidney disease with calcific aortic valve disease based on comprehensive bioinformatics analysis and machine learning

Enyi Zhu, Xiaorong Shu, Zi Xu, Yanren Peng, Yunxiu Xiang, Yu Liu, Hui Guan, Ming Zhong, Jinhong Li, Li-Zhen Zhang, Ruqiong Nie, Zhihua Zheng

Analysis of clinical features, genomic landscapes and survival outcomes in HER2-low breast cancer

Juan Jin, Bin Li, Jianing Cao, Ting Li, Jian Zhang, Jun Cao, Mingchuan Zhao, Leiping Wang, Biyun Wang, Zhonghua Tao, Xichun Hu

Dental pulp stem cell-derived exosomes revitalize salivary gland epithelial cell function in NOD mice via the GPER-mediated cAMP/PKA/CREB signaling pathway

Shilin Hu, Bo Chen, Jiannan Zhou, Fangqi Liu, Tianjiao Mao, Janak L. Pathak, Nobumoto Watanabe, Jiang Li

NUCB2/Nesfatin-1 drives breast cancer metastasis through the up-regulation of cholesterol synthesis via the mTORC1 pathway

Siyi Ning, Caiying Liu, Kangtao Wang, Yubo Cai, Zhicheng Ning, Ming Li, Liang Zeng

Group-specific cellular metabolism in Medulloblastoma

Viktoria L. E. Funke, Carolin Walter, Viktoria Melcher, Lanying Wei, Sarah Sandmann, Marc Hotfilder, Julian Varghese, Natalie Jäger, Marcel Kool, David T. W. Jones, Stefan M. Pfister, Till Milde, Martin Mynarek, Stefan Rutkowski, Jochen Seggewiss, Daniela Jeising, Flavia W. de Faria, Thorsten Marquardt, Thomas K. Albert, Ulrich Schüller, Kornelius Kerl

Maternal microbiota and gestational diabetes: impact on infant health

Parul Singh, Duaa Ahmed Idris Elhaj, Ibrahim Ibrahim, Hala Abdullahi, Souhaila Al Khodor

Mitochondrial folate pathway regulates myofibroblast differentiation and silica-induced pulmonary fibrosis

Yaqian Qu, Ruonan Zhai, Dandan Wang, Zheng Wang, Guangjie Hou, Chenchen Wu, Meian Tang, Xiongbin Xiao, Jie Jiao, Yue Ba, Fang Zhou, Jian Qiu, Wu Yao

Atrial epicardial adipose tissue abundantly secretes myeloperoxidase and activates atrial fibroblasts in patients with atrial fibrillation

Eva R. Meulendijks, Rushd F. M. Al-Shama, Makiri Kawasaki, Benedetta Fabrizi, Jolien Neefs, Robin Wesselink, Auriane C. Ernault, Sander Piersma, Thang V. Pham, Connie R. Jimenez, Jaco C. Knol, Wim J. P. van Boven, Antoine H. G. Driessen, Tim A. C. de Vries, Britt van der Leeden, Hans W. M. Niessen, Onno J. de Boer, Sébastien P. J. Krul, Joris R. de Groot

Characterization of chimeric antigen receptor modified T cells expressing scFv-IL-13Rα2 after radiolabeling with 89Zirconium oxine for PET imaging

Pamela Leland, Dhiraj Kumar, Sridhar Nimmagadda, Steven R. Bauer, Raj K. Puri, Bharat H. Joshi

Re-evaluating the risk factors for radiation pneumonitis in the era of immunotherapy

Feihu Chen, Jiling Niu, Min Wang, Hui Zhu, Zhijun Guo

The interplay between noncoding RNAs and drug resistance in hepatocellular carcinoma: the big impact of little things

Yuan Fang, XiaoLi Zhang, HanFei Huang, Zhong Zeng

Evaluating the distinct pleiotropic effects of omega-3 fatty acids on type 2 diabetes mellitus: a mendelian randomization study

Chunyan Hu, Yulin Zhou, Xueyan Wu, Xiaojing Jia, Yuanyue Zhu, Ruizhi Zheng, Shuangyuan Wang, Lin Lin, Hongyan Qi, Hong Lin, Mian Li, Tiange Wang, Zhiyun Zhao, Min Xu, Yu Xu, Yuhong Chen, Guang Ning, Maria-Carolina Borges, Weiqing Wang, Jie Zheng, Yufang Bi, Jieli Lu

Crucial role of the transcription factors family activator protein 2 in cancer: current clue and views

Chen Jin, Yuxiao Luo, Zhu Liang, Xi Li, Damian Kołat, Linyong Zhao, Weixi Xiong

Exploring the molecular mechanism of comorbidity of autism spectrum disorder and inflammatory bowel disease by combining multiple data sets

Jinyi Zhu, Haoran Meng, Li Zhang, Yan Li

Identification of colorectal cancer progression-associated intestinal microbiome and predictive signature construction

Jungang Liu, Xiaoliang Huang, Chuanbin Chen, Zhen Wang, Zigui Huang, Mingjian Qin, Fuhai He, Binzhe Tang, Chenyan Long, Hong Hu, Shuibo Pan, Junduan Wu, Weizhong Tang

Predominantly defective CD8+ T cell immunity to SARS-CoV-2 mRNA vaccination in lung transplant recipients

Ellie Taus, Michael Y. Shino, F. Javier Ibarrondo, Mary Ann Hausner, Christian Hofmann, Otto O. Yang

The relevance of pacing strategies in managing symptoms of post-COVID-19 syndrome

Alaa Ghali, Valentin Lacombe, Camille Ravaiau, Estelle Delattre, Maria Ghali, Geoffrey Urbanski, Christian Lavigne

HPV-positive murine oral squamous cell carcinoma: development and characterization of a new mouse tumor model for immunological studies

Ziva Modic, Maja Cemazar, Bostjan Markelc, Andrej Cör, Gregor Sersa, Simona Kranjc Brezar, Tanja Jesenko

Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function

Cristiana Iosef, Michael J. Knauer, Michael Nicholson, Logan R. Van Nynatten, Gediminas Cepinskas, Sorin Draghici, Victor K. M. Han, Douglas D. Fraser

Implementation of Nanopore sequencing as a pragmatic workflow for copy number variant confirmation in the clinic

Stephanie U. Greer, Jacquelin Botello, Donna Hongo, Brynn Levy, Premal Shah, Matthew Rabinowitz, Danny E. Miller, Kate Im, Akash Kumar

Downregulation of Claudin5 promotes malignant progression and radioresistance through Beclin1-mediated autophagy in esophageal squamous cell carcinoma

Shan Huang, Jiayi Zhang, Yi Li, Yaqiong Xu, Hui Jia, Lei An, Xiaotan Wang, Yuting Yang

Uncovering the mechanism of resveratrol in the treatment of diabetic kidney disease based on network pharmacology, molecular docking, and experimental validation

Shengnan Chen, Bo Li, Lei Chen, Hongli Jiang

Establishment of a potent weighted risk model for determining the progression of diabetic kidney disease

Tianxiao Zhang, Xiaodan Wang, Yueying Zhang, Ying Yang, Congying Yang, Huiyi Wei, Qingbin Zhao

HNRNPA2B1-mediated m6A modification of lncRNA MEG3 facilitates tumorigenesis and metastasis of non-small cell lung cancer by regulating miR-21-5p/PTEN axis

Ke Li, Quan Gong, Xu-Dong Xiang, Gang Guo, Jia Liu, Li Zhao, Jun Li, Nan Chen, Heng Li, Li-Juan Zhang, Chun-Yan Zhou, Zhi-Yong Wang, Li Zhuang

Inhalable CAR-T cell-derived exosomes as paclitaxel carriers for treating lung cancer

Wei Zheng, Tianchuan Zhu, Lantian Tang, Zhijian Li, Guanmin Jiang, Xi Huang

Metabolomic phenotyping of obesity for profiling cardiovascular and ocular diseases

Pingting Zhong, Shaoying Tan, Zhuoting Zhu, Gabriella Bulloch, Erping Long, Wenyong Huang, Mingguang He, Wei Wang

Assessment of brain cancer atlas maps with multimodal imaging features

Enrico Capobianco, Marco Dominietto

Translating discoveries as novel biomarkers and interventions in ophthalmology

Geoffrey K. Broadhead, Levon M. Khachigian

Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia

Michael Kurnellas, Ananya Mitra, Tina Schwabe, Robert Paul, Andrew E. Arrant, Erik D. Roberson, Michael Ward, Felix Yeh, Hua Long, Arnon Rosenthal

Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration

Lingzi Wu, Lei Zhou, Jinying An, Xianfeng Shao, Hui Zhang, Chunxi Wang, Guixia Zhao, Shuang Chen, Xuexue Cui, Xinyi Zhang, Fuhua Yang, Xiaorong Li, Xiaomin Zhang

Mitochondrial DNA induces nucleus pulposus cell pyroptosis via the TLR9-NF-κB-NLRP3 axis

Peng Lu, Huayong Zheng, Hao Meng, Chuan Liu, Lianhong Duan, Jianzheng Zhang, Zhicheng Zhang, Jie Gao, Yang Zhang, Tiansheng Sun

Predicting tumor repopulation through the gene panel derived from radiation resistant colorectal cancer cells

Yanwei Song, Zheng Deng, Haoran Sun, Yucui Zhao, Ruyi Zhao, Jin Cheng, Qian Huang

Oral microbiota may affect osteoradionecrosis following radiotherapy for head and neck cancer

Zhengrui Li, Rao Fu, Xufeng Huang, Xutao Wen, Ling Zhang

Exploring the potential of microRNA as a diagnostic tool for gestational diabetes

Duaa Ahmed Elhag, Souhaila Al Khodor

Establishment and evaluation of a novel practical tool for the diagnosis of pre-sarcopenia in young people with diabetes mellitus

Ruina Li, Sixian Lin, Jiayuan Tu, Yongzhuang Chen, Bin Cheng, Xiaoqiao Mo, Tian Xie

DHA supplementation and pregnancy complications

Yi Jiang, Yuting Chen, Lijie Wei, Huiting Zhang, Jingyi Zhang, Xuan Zhou, Shenglan Zhu, Yuanyuan Du, Rui Su, Chenyun Fang, Wencheng Ding, Ling Feng

Integrative analysis of the gut microbiota and faecal and serum short-chain fatty acids and tryptophan metabolites in patients with cirrhosis and hepatic encephalopathy

Qiang Wang, Chengxin Chen, Shi Zuo, Kun Cao, Haiyang Li

RNA aptamers with specific binding affinity to CD40 (CD40Apt) represents a promising antagonist of the CD40-CD40L signaling for thyroid-associated ophthalmopathy (TAO) treatment in mouse

Yizhi Chen, Renhong Tang, Wei Xiong, Feng Zhang, Nuo Wang, Bingyu Xie, Jiamin Cao, Zhuokun Chen, Chen Ma

Effects of sevoflurane on lung epithelial permeability in experimental models of acute respiratory distress syndrome

Ruoyang Zhai, Woodys Lenga Ma Bonda, Charlotte Leclaire, Cécile Saint-Béat, Camille Theilliere, Corinne Belville, Randy Coupet, Raiko Blondonnet, Damien Bouvier, Loic Blanchon, Vincent Sapin, Matthieu Jabaudon

Comparison of serum acylcarnitine levels in patients with myalgic encephalomyelitis/chronic fatigue syndrome and healthy controls: a systematic review and meta-analysis

Ryuhei Jinushi, Sakue Masuda, Yuki Tanisaka, Sho Nishiguchi, Kento Shionoya, Ryo Sato, Kei Sugimoto, Takahiro Shin, Rie Shiomi, Akashi Fujita, Masafumi Mizuide, Shomei Ryozawa

Induction of filopodia formation by α-Actinin-2 via RelA with a feedforward activation loop promoting overt bone marrow metastasis of gastric cancer

Caiqin Wang, Bo Xie, Shi Yin, Jianghua Cao, Junhao Huang, Longyang Jin, Ge Du, Xiaohui Zhai, Rongqin Zhang, Shanshan Li, Taiyuan Cao, Hongen Yu, Xinjuan Fan, Zuli Yang, Junsheng Peng, Jian Xiao, Lei Lian

TIMELESS upregulates PD-L1 expression and exerts an immunosuppressive role in breast cancer

Xinrui Dong, Huijuan Dai, Yanping Lin, Xiaonan Sheng, Ye Li, Yaohui Wang, Xueli Zhang, Shuheng Jiang, Wenjin Yin, Jinsong Lu

NIPSNAP1 directs dual mechanisms to restrain senescence in cancer cells

Enyi Gao, Xiaoya Sun, Rick Francis Thorne, Xu Dong Zhang, Jinming Li, Fengmin Shao, Jianli Ma, Mian Wu

CircNFATC3 promotes the proliferation of gastric cancer through binding to IGF2BP3 and restricting its ubiquitination to enhance CCND1 mRNA stability

Feifei Yang, Qiang Ma, Bo Huang, Xiaolin Wang, Xiaojuan Pan, Ting Yu, Lingyu Ran, Shan Jiang, Haiping Li, Ye Chen, Yuying Liu, Ce Liang, Junwu Ren, Yuying Zhang, Shimin Wang, Wei Li, Bin Xiao

Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing

Yu Hua, Yue Zheng, Yiran Yao, Renbing Jia, Shengfang Ge, Ai Zhuang

Novel models by machine learning to predict prognosis of breast cancer brain metastases

Chaofan Li, Mengjie Liu, Yinbin Zhang, Yusheng Wang, Jia Li, Shiyu Sun, Xuanyu Liu, Huizi Wu, Cong Feng, Peizhuo Yao, Yiwei Jia, Yu Zhang, Xinyu Wei, Fei Wu, Chong Du, Xixi Zhao, Shuqun Zhang, Jingkun Qu

Interactions between MFAP5 + fibroblasts and tumor-infiltrating myeloid cells shape the malignant microenvironment of colorectal cancer

Zhiwei Peng, Zihao Ren, Zhiwei Tong, Yinan Zhu, Yansong Zhu, Kongwang Hu

Construction and validation of prognostic models in critically Ill patients with sepsis-associated acute kidney injury: interpretable machine learning approach

Zhiyan Fan, Jiamei Jiang, Chen Xiao, Youlei Chen, Quan Xia, Juan Wang, Mengjuan Fang, Zesheng Wu, Fanghui Chen

METTL3-mediated m6A modification of SIRT1 mRNA inhibits progression of endometriosis by cellular senescence enhancing

Xiaotong Wang, Jing Wang, Xibo Zhao, Han Wu, Jixin Li, Yan Cheng, Qiuyan Guo, Xuejiao Cao, Tian Liang, Liyuan Sun, Guangmei Zhang

Clinical, pathological, and comprehensive molecular analysis of the uterine clear cell carcinoma: a retrospective national study from TMRG and GINECO network

Elsa Nigon, Claudia Lefeuvre-Plesse, Alejandra Martinez, Céline Chauleur, Alain Lortholary, Laure Favier, Anne-Sophie Bats, Arnaud Guille, José AdélaÏde, Pascal Finetti, Victoire de Casteljac, Magali Provansal, Emilie Mamessier, François Bertucci, Isabelle Ray-Coquard, Renaud Sabatier

Cuproptosis engages in c-Myc-mediated breast cancer stemness

Runtian Wang, Kun Xu, Qin Chen, Qin Hu, Jian Zhang, Xiaoxiang Guan

Implementation of genomic medicine for rare disease in a tertiary healthcare system: Mayo Clinic Program for Rare and Undiagnosed Diseases (PRaUD)

Intensive cycles of neoadjuvant camrelizumab combined with chemotherapy in locally advanced esophageal squamous cell carcinoma: a single-arm, phase II trial

Guozhen Yang, Xiaodong Su, Yuanheng Huang, Guangyu Luo, Zhiqiang Wang, Peiqiang Cai, Yating Zheng, Ting Bei, Mengli Huang, Yuezong Bai, Haoqiang He, Jin Xiang, Muyan Cai, Jiudi Zhong, Qiyu Guo, Xu Zhang

Targeting choroidal vasculopathy via up-regulation of tRNA-derived fragment tRF-22 expression for controlling progression of myopia

Chang Liu, Meiyan Li, Yaming Shen, Xiaoyan Han, Ruoyan Wei, Yunzhe Wang, Shanshan Xu, Xingtao Zhou

The new insights into autophagy in thyroid cancer progression

Yu-Bo Shi, Shu-Yuan Chen, Ren-Bin Liu

Novel method for highly multiplexed gene expression profiling of circulating tumor cells (CTCs) captured from the blood of women with metastatic breast cancer

Morvarid Farhang Ghahremani, Kelly Kai Yin Seto, Woohyun Cho, Michael Craig Miller, Paul Smith, David Frederick Englert

Development of complemented comprehensive networks for rapid screening of repurposable drugs applicable to new emerging disease outbreaks

Yonghyun Nam, Anastasia Lucas, Jae-Seung Yun, Seung Mi Lee, Ji Won Park, Ziqi Chen, Brian Lee, Xia Ning, Li Shen, Anurag Verma, Dokyoon Kim

Pharmacologic inhibition of IL11/STAT3 signaling increases MHC-I expression and T cell infiltration

Wenjun Xiong, Yuehong Chen, Chaoting Zhang, Jin Li, Haipeng Huang, Yu Zhu, Guangxu Deng, Junhong Cheng, Yixiong Lin, Zhimin Shi, Tingyu Mou

Fam20c regulates the calpain proteolysis system through phosphorylating Calpasatatin to maintain cell homeostasis

Xinpeng Liu, Lili Jiang, Wenxuan Zhang, Jiahui Zhang, Xinrui Luan, Yuanbo Zhan, Tuo Wang, Junlong Da, Lixue Liu, Shujian Zhang, Yuyao Guo, Kai Zhang, Zhiping Wang, Nan Miao, Xiaohua Xie, Peihong Liu, Ying Li, Han jin, Bin Zhang

RP11-296E3.2 acts as an important molecular chaperone for YBX1 and promotes colorectal cancer proliferation and metastasis by activating STAT3

Qian Shi, Ying He, Shouyu He, Jingjing Li, Ji Xia, Tianwei Chen, Lixia Huo, Yuhang Ling, Qinchen Liu, Wei Zang, Qiang Wang, Chengwu Tang, Xiang Wang

Intrahepatic macrophage reprogramming associated with lipid metabolism in hepatitis B virus-related acute-on-chronic liver failure

Bo Peng, Hao Li, Kai Liu, Pengpeng Zhang, Quan Zhuang, Junhui Li, Min Yang, Ke Cheng, Yingzi Ming

ST6GALNAC4 promotes hepatocellular carcinogenesis by inducing abnormal glycosylation

Da Man, Yifan Jiang, Deguo Zhang, Jingjing Wu, Bo Ding, Hanqing Liu, Guangming Xu, Jiahua Lu, Junnan Ru, Rongliang Tong, Shusheng Zheng, Diyu Chen, Jian Wu

Discovery of extracellular vesicle-delivered miR-185-5p in the plasma of patients as an indicator for advanced adenoma and colorectal cancer

Yun-Jie Shi, Yu-Xiang Fang, Tong-Guan Tian, Wei-Ping Chen, Qiang Sun, Fang-Qi Guo, Pi-Qing Gong, Chun-Mei Li, Hao Wang, Zhi-Qian Hu, Xin-Xing Li

A novel camptothecin derivative, ZBH-01, exhibits superior antitumor efficacy than irinotecan by regulating the cell cycle

Yongqi Li, Dawei Zhao, Wenqiu Zhang, Miaomiao Yang, Zhihui Wu, Weiguo Shi, Shijie Lan, Zhen Guo, Hong Yu, Di Wu

Randomized, double-blind, placebo-controlled study to evaluate the effect of treatment with an SPMs-enriched oil on chronic pain and inflammation, functionality, and quality of life in patients with symptomatic knee osteoarthritis: GAUDI study

Ingrid Möller, Gil Rodas, Jose María Villalón, Jose A. Rodas, Francisco Angulo, Nina Martínez, Josep Vergés

Pharmacological targeting of one‑carbon metabolism as a novel therapeutic strategy for glioblastoma

Yanfei Sun, Guangjing Mu, Zhiwei Xue, Xingang Li, Xiaoying Lin, Mingzhi Han

Cell death and senescence

Lorenzo Galluzzi, Melissa Myint

Growth hormone reduces aneuploidy and improves oocytes quality by JAK2-MAPK3/1 pathway in aged mice

Yun-Yao Luo, Xi Zeng, Ling Zhu, Chong Li, Juan Xie, Qiang Dong, Qing-Yuan Sun, Guo-Ning Huang, Jing-Yu Li

Inhibition of DRP1-dependent mitochondrial fission by Mdivi-1 alleviates atherosclerosis through the modulation of M1 polarization

Ze-da-zhong Su, Chun-qiu Li, Hua-wei Wang, Min-ming Zheng, Qing-wei Chen

Targeting RNA-binding protein HuR to inhibit the progression of renal tubular fibrosis

Zhimin Huang, Simeng Liu, Anna Tang, Xiaoqing Wu, Jeffrey Aube, Liang Xu, Yufeng Huang

Alterations of gut microbiota are associated with blood pressure: a cross-sectional clinical trial in Northwestern China

Jing Lv, Jihan Wang, Yan Yu, Mengyao Zhao, Wenjuan Yang, Junye Liu, Yan Zhao, Yanjie Yang, Guodong Wang, Lei Guo, Heping Zhao

Dose–effect of long-snake-like moxibustion for chronic fatigue syndrome: a randomized controlled trial

Hong Luo, Rui Gong, Rui Zheng, Jing Tan, Ruixue Chen, Jie Wu, Tingting Ma

Artificial intelligence for the prevention and prediction of colorectal neoplasms

Kohjiro Tokutake, Aaron Morelos-Gomez, Ken-ichi Hoshi, Michio Katouda, Syogo Tejima, Morinobu Endo

Efficacy of low-dose risperidone in combination with sertraline in first-episode drug-naïve patients with schizophrenia: a randomized controlled open-label study

Xiaoe Lang, Mei Xue, Xiaocui Zang, Fengchun Wu, Meihong Xiu, Xiangyang Zhang

The promoting effect and mechanism of Nrf2 on cell metastasis in cervical cancer

Mengwen Zhang, Xiaoling Hong, Ning Ma, Zhentong Wei, Xinxin Ci, Songling Zhang

Pharmacological inhibition of demethylzeylasteral on JAK-STAT signaling ameliorates vitiligo

Yuqian Chang, Pan Kang, Tingting Cui, Weinan Guo, Weigang Zhang, Pengran Du, Xiuli Yi, Sen Guo, Tianwen Gao, Chunying Li, Shuli Li

Association of non-high-density lipoprotein cholesterol trajectories with the development of non-alcoholic fatty liver disease: an epidemiological and genome-wide association study

Jun-Hyuk Lee, Jiyeon Kim, Jung Oh Kim, Yu-Jin Kwon

Association of impaired sensitivity to thyroid hormones with hyperuricemia through obesity in the euthyroid population

Zhiyuan Wu, Yue Jiang, Pingan Li, Yutao Wang, Haiping Zhang, Zhiwei Li, Xia Li, Lixin Tao, Bo Gao, Xiuhua Guo

Intraparenchymal convection enhanced delivery of AAV in sheep to treat Mucopolysaccharidosis IIIC

Claire O’Leary, Gabriella Forte, Nadia L. Mitchell, Amir Saam Youshani, Adam Dyer, Martin P. Wellby, Katharina N. Russell, Samantha J. Murray, Nelly Jolinon, Simon A Jones, Kevin Stacey, Daniel M. Davis, Els Henckaerts, David N. Palmer, Ian Kamaly-Asl, Brian W. Bigger

Oral-microbiome-derived signatures enable non-invasive diagnosis of laryngeal cancers

Shuting Yu, Junru Chen, Yan Zhao, Fangxu Yan, Yue Fan, Xin Xia, Guangliang Shan, Peng Zhang, Xingming Chen

Novel inflammatory mediator profile observed during pediatric heart surgery with cardiopulmonary bypass and continuous ultrafiltration

Joel Bierer, Roger Stanzel, Mark Henderson, Suvro Sett, John Sapp, Pantelis Andreou, Jean S. Marshall, David Horne

A systematic review and meta-analysis of urinary biomarkers in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

Asher Taccori, Rebekah Maksoud, Natalie Eaton-Fitch, Maharshi Patel, Sonya Marshall-Gradisnik

Mitochondria in endothelial cells angiogenesis and function: current understanding and future perspectives

Zhen Luo, Jianbo Yao, Zhe Wang, Jianxiong Xu

The effects of probiotics supplementation on glycaemic control among adults with type 2 diabetes mellitus: a systematic review and meta-analysis of randomised clinical trials

Guang Li, Hao Feng, Xin-Liang Mao, Yan-Jun Deng, Xiao-Bao Wang, Qiong Zhang, Yan Guo, Su-Mei Xiao

Aberrant KAT2A accumulations render TRIM22-low melanoma sensitive to Notch1 inhibitors via epigenetic reprogramming

Xiaoli Gu, Wei Min, Yibin Zeng, Ni Fan, Qihong Qian

Targeting GBM with an Oncolytic Picornavirus SVV-001 alone and in combination with fractionated Radiation in a Novel Panel of Orthotopic PDX models

Huiyuan Zhang, Yuchen Du, Lin Qi, Sophie Xiao, Frank K. Braun, Mari Kogiso, Yulun Huang, Frank Huang, Aalaa Abdallah, Milagros Suarez, Sekar Karthick, Nabil M. Ahmed, Vita S. Salsman, Patricia A. Baxter, Jack M. Su, Daniel J. Brat, Paul L. Hellenbeck, Wan-Yee Teo, Akash J. Patel, Xiao-Nan Li

PARP1 negatively regulates transcription of BLM through its interaction with HSP90AB1 in prostate cancer

Mengqiu Huang, Lin Chen, Yingchu Guo, Yong Ruan, Houqiang Xu

Genetic risk assessment of lethal prostate cancer using polygenic risk score and hereditary cancer susceptibility genes

Xiaohao Ruan, Da Huang, Jingyi Huang, James Hok-Leung Tsu, Rong Na

ChatGPT: when the artificial intelligence meets standardized patients in clinical training

Xiaoni Liu, Chaoling Wu, Rui Lai, Hai Lin, Yiying Xu, Yuansheng Lin, Weilong Zhang

Identifying a distinct fibrosis subset of NAFLD via molecular profiling and the involvement of profibrotic macrophages

Weiwei He, Yinxiang Huang, Xiulin Shi, Qingxuan Wang, Menghua Wu, Han Li, Qiuhong Liu, Xiaofang Zhang, Caoxin Huang, Xuejun Li

Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments

Gunjan Dagar, Ashna Gupta, Tariq Masoodi, Sabah Nisar, Maysaloun Merhi, Sheema Hashem, Ravi Chauhan, Manisha Dagar, Sameer Mirza, Puneet Bagga, Rakesh Kumar, Ammira S. Al-Shabeeb Akil, Muzafar A. Macha, Mohammad Haris, Shahab Uddin, Mayank Singh, Ajaz A. Bhat

Machine learning to improve interpretability of clinical, radiological and panel-based genomic data of glioma grade 4 patients undergoing surgical resection

Michele Dal Bo, Maurizio Polano, Tamara Ius, Federica Di Cintio, Alessia Mondello, Ivana Manini, Enrico Pegolo, Daniela Cesselli, Carla Di Loreto, Miran Skrap, Giuseppe Toffoli

Sodium butyrate ameliorates diabetic retinopathy in mice via the regulation of gut microbiota and related short-chain fatty acids

Yinhua Huang, Zhijie Wang, Bo Ye, Jacey Hongjie MA, Shangli Ji, Wang Sheng, Suna Ye, Yiwen Ou, Yanfang Peng, Xu Yang, Jiansu Chen, Shibo Tang

Targeting macrophagic PIM-1 alleviates osteoarthritis by inhibiting NLRP3 inflammasome activation via suppressing mitochondrial ROS/Cl− efflux signaling pathway

Zhen Zhang, Shujun Xie, Jin Qian, Fengqiang Gao, Wenjian Jin, Lingqiao Wang, Lili Yan, Hao Chen, Wangxiang Yao, Maoqiang Li, Xuepeng Wang, Liulong Zhu

USP51 promotes non-small cell lung carcinoma cell stemness by deubiquitinating TWIST1

Jin Chen, Zhongqiu Wu, Wenyi Deng, Minying Tang, Lvying Wu, Na Lin, Liuyan Chen, Yunfeng Fu, Min Zhao, Changguo Chen, Wenting Li

Salivary microbiome and hypertension in the Qatari population

Selvasankar Murugesan, Souhaila Al Khodor

The role of TET2-mediated ROBO4 hypomethylation in the development of diabetic retinopathy

Liangliang Zhao, Haitao Xu, Xin Liu, Yan Cheng, Jia’nan Xie

Prognostic risk factors of serous ovarian carcinoma based on mesenchymal stem cell phenotype and guidance for therapeutic efficacy

Xiaohui Yang, Minying Zheng, Yidi Ning, Jie Sun, Yongjun Yu, Shiwu Zhang

Impaired angiogenesis in ageing: the central role of the extracellular matrix

Ping Xiao, Yanli Zhang, Yuting Zeng, Dehong Yang, Jiayao Mo, Ziting Zheng, Jilei Wang, Yuxin Zhang, Zhiyan Zhou, Xincen Zhong, Wenjuan Yan

Identification of mitochondrial related signature associated with immune microenvironment in Alzheimer’s disease

Yaodan Zhang, Yuyang Miao, Jin Tan, Fanglian Chen, Ping Lei, Qiang Zhang

Comprehensive analysis of m6A regulators characterized by the immune microenvironment in Duchenne muscular dystrophy

Xu Han, Guang Ji, Ning Wang, Le Yi, Yafei Mao, Jinliang Deng, Hongran Wu, Shaojuan Ma, Jingzhe Han, Yi Bu, Pingping Fang, Juyi Liu, Fanzhe Sun, Xueqin Song

Correction: Mitochondria-derived vesicles and their potential roles in kidney stone disease

Sakdithep Chaiyarit, Visith Thongboonkerd

High glucose-upregulated PD-L1 expression through RAS signaling-driven downregulation of PTRH1 leads to suppression of T cell cytotoxic function in tumor environment

Chenggang Gao, Jiaoshun Chen, Jianwei Bai, Haoxiang Zhang, Yanyi Tao, Shihong Wu, Hehe Li, Heshui Wu, Qiang Shen, Tao Yin

Ketoglutaric acid can reprogram the immunophenotype of triple-negative breast cancer after radiotherapy and improve the therapeutic effect of anti-PD-L1

Hongpei Tan, Jiahao Liu, Jing Huang, Yanan Li, Qiongxuan Xie, Yuqian Dong, Ze Mi, Xiaoqian Ma, Pengfei Rong

Hyperuricemia and gout increased the risk of long-term mortality in patients with heart failure: insights from the National Health and Nutrition Examination Survey

Yingdong Han, Yu Cao, Xinxin Han, Hong Di, Yue Yin, Juan Wu, Yun Zhang, Xuejun Zeng

Elevated CHCHD4 orchestrates mitochondrial oxidative phosphorylation to disturb hypoxic pulmonary hypertension

Yu Wang, Zhenyu Zeng, Zhaoxiang Zeng, Guojun Chu, Xinghua Shan

Development and validation of a clinic machine-learning nomogram for the prediction of risk stratifications of prostate cancer based on functional subsets of peripheral lymphocyte

Chunguang Yang, Zhenghao Liu, Yin Fang, Xinyu Cao, Guoping Xu, Zhihua Wang, Zhiquan Hu, Shaogang Wang, Xinglong Wu

A precise molecular subtyping of ulcerative colitis reveals the immune heterogeneity and predicts clinical drug responses

Shaocong Mo, Bryan Jin, Yujen Tseng, Lingxi Lin, Lishuang Lin, Xin Shen, Huan Song, Mingjia Kong, Zhongguang Luo, Yiwei Chu, Chen Jiang, Zhiwei Cao, Jie Liu, Feifei Luo

Flubendazole inhibits PD-1 and suppresses melanoma growth in immunocompetent mice

Yue Li, Ben Wu, Md Jakir Hossain, Lily Quagliata, Connor O’Meara, Marc R. Wilkins, Susan Corley, Levon M. Khachigian

Orchestrating smart therapeutics to achieve optimal treatment in small cell lung cancer: recent progress and future directions

Chenyue Zhang, Chenxing Zhang, Kai Wang, Haiyong Wang

Time spent in a better cardiovascular health and risk of cardiovascular diseases and mortality: a prospective cohort study

Qiuyue Tian, Shuohua Chen, Xiaoni Meng, Haotian Wang, Cancan Li, Deqiang Zheng, Lijuan Wu, Aitian Wang, Shouling Wu, Youxin Wang

Single-cell analysis of white adipose tissue reveals the tumor-promoting adipocyte subtypes

Si-Qing Liu, Ding-Yuan Chen, Bei Li, Zhi-Jie Gao, Hong-Fang Feng, Xin Yu, Zhou Liu, Yuan Wang, Wen-Ge Li, Si Sun, Sheng-Rong Sun, Qi Wu

Development and validation of a blood biomarker score for predicting mortality risk in the general population

Jing Yang, Jiayi Lu, Junyan Miao, Jiacong Li, Meng Zhu, Juncheng Dai, Hongxia Ma, Guangfu Jin, Dong Hang

Maresin1 alleviates liver ischemia/reperfusion injury by reducing liver macrophage pyroptosis

Tong Li, Houshuai Zeng, Wenjing Xian, Hongxing Cai, Jianbo Zhang, Shiji Zhou, Yingxue Yang, Min Luo, Peng Zhu

IL-1RA promotes oral squamous cell carcinoma malignancy through mitochondrial metabolism-mediated EGFR/JNK/SOX2 pathway

Shyng-Shiou F. Yuan, Yun-Ming Wang, Leong-Perng Chan, Amos C. Hung, Hieu D. H. Nguyen, Yuk-Kwan Chen, Stephen Chu‐Sung Hu, Steven Lo, Yen-Yun Wang

CHSY3 promotes proliferation and migration in gastric cancer and is associated with immune infiltration

Xinkun Huang, Yonghui Liu, Chenyu Qian, Qicheng Shen, Menglong Wu, Bin Zhu, Ying Feng

TGF-β1 dominates stromal fibroblast-mediated EMT via the FAP/VCAN axis in bladder cancer cells

Qinrong Ping, Chunhui Wang, Xin Cheng, Yiming Zhong, Ruping Yan, Meng Yang, Yunqiang Shi, Xiangmeng Li, Xiao Li, Wenwen Huang, Liqiong Wang, Xiaofang Bi, Libing Hu, Yang Yang, Yingbao Wang, Rui Gong, Jun Tan, Rui Li, Hui Li, Jian Li, Wenju Wang, Ruhong Li

Genetic characterization of dilated cardiomyopathy patients undergoing heart transplantation in the Chinese population by whole-exome sequencing

Hong Lian, Shen Song, Wenzheng Chen, Anteng Shi, Haobin Jiang, Shengshou Hu

Unraveling the epigenetic landscape of pulmonary arterial hypertension: implications for personalized medicine development

Jaydev Dave, Vineeta Jagana, Radoslav Janostiak, Malik Bisserier

Comparison of immunotherapy mediated by apoptotic bodies, microvesicles and exosomes: apoptotic bodies’ unique anti-inflammatory potential

Jing Wen, Dale Creaven, Xiangshu Luan, Jiemin Wang

Can the ketogenic diet improve our dreams? Effect of very low-calorie ketogenic diet (VLCKD) on sleep quality

Luigi Barrea, Ludovica Verde, Cherubino Di Lorenzo, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri

Endoplasmic reticulum stress: a novel targeted approach to repair bone defects by regulating osteogenesis and angiogenesis

Tingyu Wu, Yaping Jiang, Weipeng Shi, Yingzhen Wang, Tao Li

DNMT3A mutation promotes leukemia development through NAM-NAD metabolic reprogramming

Xuejiao Yang, Xiao Wang, Ying Yang, Zhiyang Li, Yunshuo Chen, Siqi Shang, Yueying Wang

Adherence to the Paleolithic diet and Paleolithic-like lifestyle reduce the risk of colorectal cancer in the United States: a prospective cohort study

Yi Xiao, Yaxu Wang, Haitao Gu, Zhiquan Xu, Yunhao Tang, Hongmei He, Linglong Peng, Ling Xiang

Attenuated Dengue virus PV001-DV induces oncolytic tumor cell death and potent immune responses

Josef W. Goldufsky, Preston Daniels, Michael D. Williams, Kajal Gupta, Bruce Lyday, Tony Chen, Geeta Singh, Howard L. Kaufman, Andrew Zloza, Amanda L. Marzo

Association between periodontitis and the prevalence and prognosis of prediabetes: a population-based study

Liao Tan, Jie Liu, Zhaoya Liu

Ensemble learning model for identifying the hallmark genes of NFκB/TNF signaling pathway in cancers

Yin-Yuan Su, Yu-Ling Liu, Hsuan-Cheng Huang, Chen-Ching Lin

An Fgr kinase inhibitor attenuates sepsis-associated encephalopathy by ameliorating mitochondrial dysfunction, oxidative stress, and neuroinflammation via the SIRT1/PGC-1α signaling pathway

Yuqiang Liu, Han Yang, Nanbo Luo, Yifei Fu, Fang Qiu, Zhenglong Pan, Xiongjuan Li, Wenling Jian, Xinping Yang, Qingsheng Xue, Yan Luo, Buwei Yu, Zhiheng Liu

L-carnitine promotes liver regeneration after hepatectomy by enhancing lipid metabolism

Xi Zhou, Guobin Huang, Lu Wang, Yuanyuan Zhao, Junbo Li, Dong Chen, Lai Wei, Zhishui Chen, Bo Yang

Perspectives in Immunotherapy: meeting report from Immunotherapy Bridge (Naples, November 30th–December 1st, 2022)

Paolo A. Ascierto, Antonio Avallone, Carlo Bifulco, Sergio Bracarda, Joshua D. Brody, Leisha A. Emens, Robert L. Ferris, Silvia C. Formenti, Omid Hamid, Douglas B. Johnson, Tomas Kirchhoff, Christopher A. Klebanoff, Gregory B. Lesinski, Anne Monette, Bart Neyns, Kunle Odunsi, Chrystal M. Paulos, Daniel J. Powell Jr., Katayoun Rezvani, Brahm H. Segal, Nathan Singh, Ryan J. Sullivan, Bernard A. Fox, Igor Puzanov

Spatial heterogeneity of tumor microenvironment influences the prognosis of clear cell renal cell carcinoma

Dawei Zhang, Yuanli Ni, Yongquan Wang, Juan Feng, Na Zhuang, Jiatao Li, Limei Liu, Wenhao Shen, Ji Zheng, Wei Zheng, Cheng Qian, Juanjuan Shan, Zhansong Zhou

Identification of pyroptosis-related genes and potential drugs in diabetic nephropathy

Meng Yan, Wenwen Li, Rui Wei, Shuwen Li, Yan Liu, Yuqian Huang, Yunye Zhang, Zihao Lu, Qian Lu

Elucidating shared biomarkers and pathways in kidney stones and diabetes: insights into novel therapeutic targets and the role of resveratrol

Shanlin Shen, Jiafeng Wei, Weiting Kang, Tengteng Wang

Dietary flavonoids intake contributes to delay biological aging process: analysis from NHANES dataset

Wenmin Xing, Wenyan Gao, Zhenlei Zhao, Xiaogang Xu, Hongyan Bu, Huili Su, Genxiang Mao, Jun Chen

Chimeric antigen receptor T cells targeting cell surface GRP78 efficiently kill glioblastoma and cancer stem cells

Shijie Wang, Wenwen Wei, Yuncang Yuan, Bin Sun, Dong Yang, Nan Liu, Xudong Zhao

SIRT3 ameliorates diabetes-associated cognitive dysfunction via regulating mitochondria-associated ER membranes

Yanmin Chang, Cailin Wang, Jiahui Zhu, Siyi Zheng, Shangqi Sun, Yanqing Wu, Xingjun Jiang, Lulu Li, Rong Ma, Gang Li

Time- and cost-effective production of untagged recombinant MVA by flow virometry and direct virus sorting

Daniela Boselli, Maddalena Panigada, Simona Di Terlizzi, Monica Romanò, Emanuele Canonico, Chiara Villa, Claudia Minici, Eelco van Anken, Elisa Soprana, Antonio G. Siccardi

Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia

Qian Chen, Jiexing He, Haihua Liu, Qiuyu Huang, Shuoshi Wang, Ailan Yin, Shuying Chen, Xinyang Shen, Yanxuan Xiao, Haoyue Hu, Jiayi Jiang, Wenqian Chen, Song Wang, Zhenqin Huang, Jiaqi Li, You Peng, Xiaocong Wang, Xinping Yang, Zhijian Wang, Mei Zhong

Transcriptome profile and immune infiltrated landscape revealed a novel role of γδT cells in mediating pyroptosis in celiac disease

Shuze Chen, Xiuying Liu, Zhi Wang, Dekai Zheng, Ying Wang, Yiling Yan, Xiaojie Peng, Qiujuan Ye, Ye Chen

Insulin alleviates murine colitis through microbiome alterations and bile acid metabolism

Shuying He, Jiating Li, Zirong Yao, Zixian Gao, Yonghong Jiang, Xueqing Chen, Liang Peng

Integration of single-cell regulon atlas and multi-omics data for prognostic stratification and personalized treatment prediction in human lung adenocarcinoma

Yi Xiong, Yihao Zhang, Na Liu, Yueshuo Li, Hongwei Liu, Qi Yang, Yu Chen, Zhizhi Xia, Xin Chen, Siyi Wanggou, Xuejun Li

Oncolytic virotherapy evolved into the fourth generation as tumor immunotherapy

Xianwang Wang, Yihua Shen, Xingxia Wan, Xiaoqing Hu, Wen-Qi Cai, Zijun Wu, Qiang Xin, Xiaoqing Liu, Jingang Gui, Hong-Yi Xin, Hong-Wu Xin

Adapting modeling and simulation credibility standards to computational systems biology

Lillian T. Tatka, Lucian P. Smith, Joseph L. Hellerstein, Herbert M. Sauro

Evaluate the accuracy of ChatGPT’s responses to diabetes questions and misconceptions

Chunling Huang, Lijun Chen, Huibin Huang, Qingyan Cai, Ruhai Lin, Xiaohong Wu, Yong Zhuang, Zhengrong Jiang

Mitochondrial dysfunction: roles in skeletal muscle atrophy

Xin Chen, Yanan Ji, Ruiqi Liu, Xucheng Zhu, Kexin Wang, Xiaoming Yang, Boya Liu, Zihui Gao, Yan Huang, Yuntian Shen, Hua Liu, Hualin Sun

A traditional gynecological medicine inhibits ovarian cancer progression and eliminates cancer stem cells via the LRPPRC–OXPHOS axis

Ruibin Jiang, Zhongjian Chen, Maowei Ni, Xia Li, Hangjie Ying, Jianguo Fen, Danying Wan, Chanjuan Peng, Wei Zhou, Linhui Gu

Novel heavily fucosylated glycans as a promising therapeutic target in colorectal cancer

Kuei-Yen Tsai, Yu-Jia Chang, Chien-Yu Huang, G. M. Shazzad Hossain Prince, Hsin-An Chen, Precious Takondwa Makondi, Ying-Rou Shen, Po-Li Wei

Immunostimulatory gene therapy targeting CD40, 4-1BB and IL-2R activates DCs and stimulates antigen-specific T-cell and NK-cell responses in melanoma models

Jessica Wenthe, Emma Eriksson, Ann-Charlotte Hellström, Rafael Moreno, Gustav Ullenhag, Ramon Alemany, Tanja Lövgren, Angelica Loskog

Radiomics using computed tomography to predict CD73 expression and prognosis of colorectal cancer liver metastases

Ralph Saber, David Henault, Nouredin Messaoudi, Rolando Rebolledo, Emmanuel Montagnon, Geneviève Soucy, John Stagg, An Tang, Simon Turcotte, Samuel Kadoury

Perspectives in Melanoma: meeting report from the Melanoma Bridge (December 1st–3rd, 2022—Naples, Italy)

Paolo A. Ascierto, Sanjiv S. Agarwala, Allison Betof Warner, Marc S. Ernstoff, Bernard A. Fox, Thomas F. Gajewski, Jérôme Galon, Claus Garbe, Brian R. Gastman, Jeffrey E. Gershenwald, Pawel Kalinski, Michelle Krogsgaard, Rom S. Leidner, Roger S. Lo, Alexander M. Menzies, Olivier Michielin, Poulikos I. Poulikakos, Jeffrey S. Weber, Corrado Caracò, Iman Osman, Igor Puzanov, Magdalena Thurin

Hsa_circ_0002348 regulates trophoblast proliferation and apoptosis through miR-126-3p/BAK1 axis in preeclampsia

Jizi Zhou, Ying Zhao, Ping An, Huanqiang Zhao, Xiaotian Li, Yu Xiong

Mitochondrial metabolic dysfunction and non-alcoholic fatty liver disease: new insights from pathogenic mechanisms to clinically targeted therapy

Youwei Zheng, Shiting Wang, Jialiang Wu, Yong Wang

Discovery of therapeutic targets for spinal cord injury based on molecular mechanisms of axon regeneration after conditioning lesion

Xiaoxiong Wang, Wenxiang Li, Jianping Zhang, Jinze Li, Xianjin Zhang, Min Wang, Zhijian Wei, Shiqing Feng

RNA binding protein: coordinated expression between the nuclear and mitochondrial genomes in tumors

Jiaoyan Ma, Liankun Sun, Weinan Gao, Yang Li, Delu Dong

Randomized, double-blinded, placebo-controlled pilot study: efficacy of faecal microbiota transplantation on chronic fatigue syndrome

Tapani Salonen, Elina Jokinen, Reetta Satokari, Perttu Lahtinen

Ferroptosis in tumors and its relationship to other programmed cell death: role of non-coding RNAs

Qi Zhang, Xinfeng Fan, Xinyu Zhang, Shaoqing Ju

Complexities in comparing the impact of costimulatory domains on approved CD19 CAR functionality

Richard Smith, Rhine Shen

Recent advances of exosomal circRNAs in cancer and their potential clinical applications

Qian Yi, Jiaji Yue, Yang Liu, Houyin Shi, Wei Sun, Jianguo Feng, Weichao Sun

A novel explainable online calculator for contrast-induced AKI in diabetics: a multi-centre validation and prospective evaluation study

Mengqing Ma, Xin Wan, Yuyang Chen, Zhichao Lu, Danning Guo, Huiping Kong, Binbin Pan, Hao Zhang, Dawei Chen, Dongxu Xu, Dong Sun, Hong Lang, Changgao Zhou, Tao Li, Changchun Cao

Association between Chinese visceral adiposity index and risk of stroke incidence in middle-aged and elderly Chinese population: evidence from a large national cohort study

Zenglei Zhang, Lin Zhao, Yiting Lu, Xu Meng, Xianliang Zhou

Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease

Qian Yan, Shasha Liu, Yang Sun, Chen Chen, Songwei Yang, Meiyu Lin, Junpeng Long, Jiao Yao, Yuting Lin, Fan Yi, Lei Meng, Yong Tan, Qidi Ai, Naihong Chen, Yantao Yang

Subject: Motivation can be suppressed, but scientific ability cannot and should not be ignored

Najmaldin Saki, Habib Haybar, Mojtaba Aghaei

UCP1 alleviates renal interstitial fibrosis progression through oxidative stress pathway mediated by SIRT3 protein stability

Wei Xiong, Zhiyong Xiong, Anni Song, Chuntao Lei, Chen Ye, Hua Su, Chun Zhang

Downregulation of mitochondrial complex I induces ROS production in colorectal cancer subtypes that differently controls migration

Jean Bastin, Marine Sroussi, Ivan Nemazanyy, Pierre Laurent-Puig, Sophie Mouillet-Richard, Fatima Djouadi

GSG2 facilitates the progression of human breast cancer through MDM2-mediated ubiquitination of E2F1

Yu Tang, Gaosai Dai, Yupeng Yang, Huantao Liu

Correction: NUCB2/Nesfatin-1 drives breast cancer metastasis through the up-regulation of cholesterol synthesis via the mTORC1 pathway

Siyi Ning, Caiying Liu, Kangtao Wang, Yubo Cai, Zhicheng Ning, Ming Li, Liang Zeng

Effects of probiotic administration on overweight or obese children: a meta-analysis and systematic review

Ya Li, Tonghua Liu, Lingling Qin, Lili Wu

Advances in radiotherapy and immunity in hepatocellular carcinoma

Yuhan Yang, Liting Xiong, Mengyuan Li, Ping Jiang, Junjie Wang, Chunxiao Li

Mendelian randomization and transcriptomic analysis reveal an inverse causal relationship between Alzheimer’s disease and cancer

Zehua Dong, Mengli Xu, Xu Sun, Xiaosheng Wang

Spatial tumour gene signature discriminates neoplastic from non-neoplastic compartments in colon cancer: unravelling predictive biomarkers for relapse

Katja Sallinger, Michael Gruber, Christin-Therese Müller, Lilli Bonstingl, Elisabeth Pritz, Karin Pankratz, Armin Gerger, Maria Anna Smolle, Ariane Aigelsreiter, Olga Surova, Jessica Svedlund, Mats Nilsson, Thomas Kroneis, Amin El-Heliebi

The role of triple therapy and therapy sequence in treatment of BRAF-mutant metastatic melanoma. Response to overall survival with first-line atezolizumab in combination with vemurafenib and cobimetinib in BRAFV600 mutation-positive advanced melanoma (IMspire150): second interim analysis of a multicentre, randomised, phase 3 study

Reinhard Dummer, Michèle Welti, Egle Ramelyte

Epithelial cell adhesion molecule (EpCAM) regulates HGFR signaling to promote colon cancer progression and metastasis

Chi-Chiu Lee, Chia-Jui Yu, Sushree Shankar Panda, Kai-Chi Chen, Kang-Hao Liang, Wan-Chen Huang, Yu-Shiuan Wang, Pei-Chin Ho, Han-Chung Wu

Remnant cholesterol, but not other cholesterol parameters, is associated with gestational diabetes mellitus in pregnant women: a prospective cohort study

Yajing Gao, Yanhua Hu, Lan Xiang

Preclinical evaluation of Mito-LND, a targeting mitochondrial metabolism inhibitor, for glioblastoma treatment

Tongxuan Guo, Changyong Wu, Lingni Zhou, Junhao Zhang, Wanzhou Wang, Yang Shen, Ludong Zhang, Mingshan Niu, Xu Zhang, Rutong Yu, Xuejiao Liu

COVPRIG robustly predicts the overall survival of IDH wild-type glioblastoma and highlights METTL1+ neural-progenitor-like tumor cell in driving unfavorable outcome

Hang Ji, Fang Wang, Zhihui Liu, Yue Li, Haogeng Sun, Anqi Xiao, Huanxin Zhang, Chao You, Shaoshan Hu, Yi Liu

Basic, translational and clinical studies in reproductive medicine and clinical reproductive sciences

Fadi Choucair, Matteo Avella

Identification of host gene-microbiome associations in colorectal cancer patients using mendelian randomization

Yaoxian Xiang, Chan Zhang, Jing Wang, Yurong Cheng, Li Wang, Yingying Tong, Dong Yan

BMI trajectory of rapid and excessive weight gain during adulthood is associated with bone loss: a cross-sectional study from NHANES 2005–2018

Jiacheng Wang, Yi Zheng, Yawen Wang, Chengjun Zhang, Yanfeng Jiang, Chen Suo, Mei Cui, Tiejun Zhang, Xingdong Chen, Kelin Xu

Weighted gene coexpression network analysis and machine learning reveal oncogenome associated microbiome plays an important role in tumor immunity and prognosis in pan-cancer

Shi-Wei Guan, Quan Lin, Xi-Dong Wu, Hai-Bo Yu

Association of dietary inflammatory index with helicobacter pylori infection and mortality among US population

Yu-Jun Xiong, Lei-Lei Du, Yun-Lian Diao, Jun Wen, Xiang-Bin Meng, Jun Gao, Chun-Li Shao, Wen-Yao Wang, Xing-yun Zhu, Yi-Da Tang

CD58 acts as a tumor promotor in hepatocellular carcinoma via activating the AKT/GSK-3β/β-catenin pathway

Chuanzheng Wang, Fei Cao, Jiahao Cao, Zhen Jiao, Yuting You, Yu Xiong, Wenxiu Zhao, Xiaomin Wang

Decreased cyclooxygenase-2 associated with impaired megakaryopoiesis and thrombopoiesis in primary immune thrombocytopenia

Xibing Zhuang, Pengcheng Xu, Yang Ou, Xia Shao, Ying Li, Yanna Ma, Shanshan Qin, Fanli Hua, Yanxia Zhan, Lili Ji, Tiankui Qiao, Hao Chen, Yunfeng Cheng

Influence of arterial blood gases on the renal arterial resistive index in intensive care unit

Stéphanie Ruiz, Fanny Vardon-Bounes, Marie Virtos, Thierry Seguin, Laure Crognier, Antoine Rouget, Bernard Georges, Jean-Marie Conil, Vincent Minville

GPRC5D as a promising therapeutic target in EGFR-wild and immuno-cold non-small cell lung cancer

Jie Mei, Yun Cai, Guanyu Jiang, Zhao He, Ruixin Wang, Chenghu Song, Yuan Wan, Wenjun Mao

Investigations of brain-wide functional and structural networks of dopaminergic and CamKIIα-positive neurons in VTA with DREADD-fMRI and neurotropic virus tracing technologies

Ning Zheng, Zhu Gui, Xiaodong Liu, Yang Wu, Huadong Wang, Aoling Cai, Jinfeng Wu, Xihai Li, Challika Kaewborisuth, Zhijian Zhang, Qitian Wang, Anne Manyande, Fuqiang Xu, Jie Wang

TNFSF14/LIGHT promotes cardiac fibrosis and atrial fibrillation vulnerability via PI3Kγ/SGK1 pathway-dependent M2 macrophage polarisation

Yirong Wu, Siyao Zhan, Lian Chen, Mingrui Sun, Miaofu Li, Xuanting Mou, Zhen Zhang, Linhao Xu, Yizhou Xu

HBO treatment enhances motor function and modulates pain development after sciatic nerve injury via protection the mitochondrial function

Yaseen Awad-Igbaria, Nadine Ferreira, Ali Keadan, Reem Sakas, Doron Edelman, Alon Shamir, Jean Francous-Soustiel, Eilam Palzur

Stargardt disease-associated in-frame ABCA4 exon 17 skipping results in significant ABCA4 function

Melita Kaltak, Rocio Blanco-Garavito, Laurie L. Molday, Claire-Marie Dhaenens, Eric E. Souied, Gerard Platenburg, Jim Swildens, Robert S. Molday, Frans P. M. Cremers

Warburg effect enhanced by AKR1B10 promotes acquired resistance to pemetrexed in lung cancer-derived brain metastasis

Wenzhe Duan, Wenwen Liu, Shengkai Xia, Yang Zhou, Mengyi Tang, Mingxin Xu, Manqing Lin, Xinyu Li, Qi Wang

Platelet-derived circRNAs signature in patients with gastroenteropancreatic neuroendocrine tumors

Federica Campolo, Franz Sesti, Tiziana Feola, Giulia Puliani, Antongiulio Faggiano, Maria Grazia Tarsitano, Marta Tenuta, Valeria Hasenmajer, Elisabetta Ferretti, Monica Verrico, Daniele Gianfrilli, Mary Anna Venneri, Andrea M. Isidori, Elisa Giannetta

Integrated multi-omics analyses reveal Jorunnamycin A as a novel suppressor for muscle-invasive bladder cancer by targeting FASN and TOP1

Ruijiao Chen, Xiaopeng Hao, Jingyuan Chen, Changyue Zhang, Huixia Fan, Fuming Lian, Xiaochuan Chen, Chao Wang, Yong Xia

Correction: A bispecific antibody AP203 targeting PD-L1 and CD137 exerts potent antitumor activity without toxicity

Po-Lin Huang, Hung-Tsai Kan, Ching-Hsuan Hsu, Hsin-Ta Hsieh, Wan-Chien Cheng, Ren-Yeong Huang, Jhong-Jhe You

Eosinophils in the tumor microenvironment: implications for cancer immunotherapy

Sasan Ghaffari, Nima Rezaei

The tight junction protein claudin 6 is a potential target for patient-individualized treatment in esophageal and gastric adenocarcinoma and is associated with poor prognosis

Adrian Georg Simon, Su Ir Lyu, Mark Laible, Stefan Wöll, Özlem Türeci, Uğur Şahin, Hakan Alakus, Luca Fahrig, Thomas Zander, Reinhard Buettner, Christiane Josephine Bruns, Wolfgang Schroeder, Florian Gebauer, Alexander Quaas

Rutaecarpine induces the differentiation of triple-negative breast cancer cells through inhibiting fumarate hydratase

Jie Lei, Yujia Pan, Rui Gao, Bin He, Zifeng Wang, Xinxing Lei, Zijian Zhang, Na Yang, Min Yan

Dynamic alterations in metabolomics and transcriptomics associated with intestinal fibrosis in a 2,4,6-trinitrobenzene sulfonic acid-induced murine model

Jinzhen Wu, Zhenyi Tian, Xiaoduan Zhuang, Yiru Chen, Tingting Fan, Jiayun Li, Xinying Wang

Targeting FSCN1 with an oral small-molecule inhibitor for treating ocular neovascularization

Wen Bai, Jun-Song Ren, Min Xia, Ya Zhao, Jing-Juan Ding, Xi Chen, Qin Jiang

Long non-coding RNAs as the critical regulators of PI3K/AKT, TGF-β, and MAPK signaling pathways during breast tumor progression

Amirhosein Maharati, Meysam Moghbeli

Uplifts and hassles are related to worsening in chronic fatigue syndrome: a prospective study

Fred Friedberg, Jenna L. Adamowicz, Patricia Bruckenthal, Maria Milazzo, Sameera Ramjan, Xiaoyue Zhang, Jie Yang

Pancancer network analysis reveals key master regulators for cancer invasiveness

Mahesh Jethalia, Siddhi P. Jani, Michele Ceccarelli, Raghvendra Mall

Altered insulin secretion dynamics relate to oxidative stress and inflammasome activation in children with obesity and insulin resistance

Álvaro González-Domínguez, Thalía Belmonte, Jesús Domínguez-Riscart, Pablo Ruiz-Ocaña, Inés Muela-Zarzuela, Ana Saez-Benito, Raúl Montañez-Martínez, Rosa M. Mateos, Alfonso M. Lechuga-Sancho

Phosphodiesterase and psychiatric disorders: a two-sample Mendelian randomization study

Miaomiao Jiang, Weiheng Yan, Yuyanan Zhang, Zhe Lu, Tianlan Lu, Dai Zhang, Jun Li, Lifang Wang

A compendium of mitochondrial molecular characteristics provides novel perspectives on the treatment of rheumatoid arthritis patients

Qi Wang, Qi-Chao Gao, Qi-Chuan Wang, Li Wu, Qi Yu, Pei-Feng He

Alpha-melanocyte stimulating hormone (α-MSH): biology, clinical relevance and implication in melanoma

Luigi Dall’Olmo, Nicole Papa, Nicoletta Concetta Surdo, Ilaria Marigo, Simone Mocellin

Acetylglutamine facilitates motor recovery and alleviates neuropathic pain after brachial plexus root avulsion in rats

Lin Wu, Shuangxi Chen, Bing He, Guijuan Zhou, Yan Xu, Guanghua Zhu, Juan Xie, Limin Deng, Xuanwei Wen, Sijing Li, Zijian Xiao

Peripheral immune landscape for hypercytokinemia in myasthenic crisis utilizing single-cell transcriptomics

Huahua Zhong, Xiao Huan, Rui Zhao, Manqiqige Su, Chong Yan, Jie Song, Jianying Xi, Chongbo Zhao, Feifei Luo, Sushan Luo

Low-intensity pulsed ultrasound ameliorates glia-mediated inflammation and neuronal damage in experimental intracerebral hemorrhage conditions

Wei-Shen Su, Chun-Hu Wu, Wen-Shin Song, Szu-Fu Chen, Feng-Yi Yang

An arrhythmogenic metabolite in atrial fibrillation

Julia Krause, Alexander Nickel, Alexandra Madsen, Hamish M. Aitken-Buck, A. M. Stella Stoter, Jessica Schrapers, Francisco Ojeda, Kira Geiger, Melanie Kern, Michael Kohlhaas, Edoardo Bertero, Patrick Hofmockel, Florian Hübner, Ines Assum, Matthias Heinig, Christian Müller, Arne Hansen, Tobias Krause, Deung-Dae Park, Steffen Just, Dylan Aïssi, Daniela Börnigen, Diana Lindner, Nele Friedrich, Khaled Alhussini, Constanze Bening, Renate B. Schnabel, Mahir Karakas, Licia Iacoviello, Veikko Salomaa, Allan Linneberg, Hugh Tunstall-Pedoe, Kari Kuulasmaa, Paulus Kirchhof, Stefan Blankenberg, Torsten Christ, Thomas Eschenhagen, Regis R. Lamberts, Christoph Maack, Justus Stenzig, Tanja Zeller

Inhibiting NLRP3 inflammasome signaling pathway promotes neurological recovery following hypoxic-ischemic brain damage by increasing p97-mediated surface GluA1-containing AMPA receptors

Yuxin Chen, Xiaohuan Li, Qian Xiong, Yehong Du, Man Luo, Lilin Yi, Yayan Pang, Xiuyu Shi, Yu Tian Wang, Zhifang Dong

ACLY as a modulator of liver cell functions and its role in Metabolic Dysfunction-Associated Steatohepatitis

Paolo Convertini, Anna Santarsiero, Simona Todisco, Michele Gilio, Donatella Palazzo, Ilaria Pappalardo, Dominga Iacobazzi, Maria Frontuto, Vittoria Infantino

Hyperoside protects against oxidative stress-mediated photoreceptor degeneration: therapeutic potentials for photoreceptor degenerative diseases

Daijin Li, Jing Xu, Jie Chang, Yujue Wang, Xiaoye Du, Hanhan Wu, Jingang Cui, Peiwei Wang, Teng Zhang, Yu Chen

Single-cell RNA sequencing reveals small extracellular vesicles derived from malignant cells that contribute to angiogenesis in human breast cancers

Youxue Zhang, Fang Zhen, Yue Sun, Bing Han, Hongyi Wang, Yuhang Zhang, Huaixi Zhang, Jing Hu

Correction: Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments

Gunjan Dagar, Ashna Gupta, Tariq Masoodi, Sabah Nisar, Maysaloun Merhi, Sheema Hashem, Ravi Chauhan, Manisha Dagar, Sameer Mirza, Puneet Bagga, Rakesh Kumar, Ammira S. Al-Shabeeb Akil, Muzafar A. Macha, Mohammad Haris, Shahab Uddin, Mayank Singh, Ajaz A. Bhat

Improving the cytotoxicity of immunotoxins by reducing the affinity of the antibody in acidic pH

Xiaoyu Liu, Qingqing Tan, Jiaqi Wen, Xufei Wang, Gang Yang, Yuxiao Li, Ming Lu, Wei Ye, Anfeng Si, Sujuan Ma, Tong Ding, Luan Sun, Fang Liu, Mei Zhang, Tao Jiang, Wei Gao

CX3CL1 promotes M1 macrophage polarization and osteoclast differentiation through NF-κB signaling pathway in ankylosing spondylitis in vitro

Xinzhe Feng, Shanbang Zhu, Junjie Qiao, Zhou Ji, Bole Zhou, Weidong Xu

DARS2 overexpression is associated with PET/CT metabolic parameters and affects glycolytic activity in lung adenocarcinoma

Xu-Sheng Liu, Ling-Ling Yuan, Yan Gao, Xing Ming, Yao-Hua Zhang, Yu Zhang, Zi-Yue Liu, Yi Yang, Zhi-Jun Pei

Glutathione Peroxidase 3 induced mitochondria-mediated apoptosis via AMPK /ERK1/2 pathway and resisted autophagy-related ferroptosis via AMPK/mTOR pathway in hyperplastic prostate

Yan Li, Yongying Zhou, Daoquan Liu, Zhen Wang, Jizhang Qiu, Junchao Zhang, Ping Chen, Guang Zeng, Yuming Guo, Xinghuan Wang, Michael E. DiSanto, Xinhua Zhang

Prognostic biomarkers for the response to the radiosensitizer nimorazole combined with RCTx: a pre-clinical trial in HNSCC xenografts

Lydia Koi, Verena Bitto, Corina Weise, Lisa Möbius, Annett Linge, Steffen Löck, Ala Yaromina, María José Besso, Chiara Valentini, Manuel Pfeifer, Jens Overgaard, Daniel Zips, Ina Kurth, Mechthild Krause, Michael Baumann

Multiparametric chemical exchange saturation transfer MRI detects metabolic changes in breast cancer following immunotherapy

Emily Hoffmann, Daniel Schache, Carsten Höltke, Jens Soltwisch, Stephan Niland, Tobias Krähling, Klaus Bergander, Martin Grewer, Christiane Geyer, Linda Groeneweg, Johannes A. Eble, Thomas Vogl, Johannes Roth, Walter Heindel, Bastian Maus, Anne Helfen, Cornelius Faber, Moritz Wildgruber, Mirjam Gerwing, Verena Hoerr

SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression

Nuno Bastos, Stéphanie A. Castaldo, Bárbara Adem, José C. Machado, Carlos A. Melo, Sonia A. Melo

Discovery of novel JAK1 inhibitors through combining machine learning, structure-based pharmacophore modeling and bio-evaluation

Zixiao Wang, Lili Sun, Yu Xu, Peida Liang, Kaiyan Xu, Jing Huang

Identifying prognostic markers in spatially heterogeneous breast cancer microenvironment

Guohong Liu, Liping Wang, Lili Ji, Dan He, Lihua Zeng, Guangzheng Zhuo, Qian Zhang, Dujuan Wang, Yunbao Pan

Quantitative proteomic and phosphoproteomic analysis reveal the relationship between mitochondrial dysfunction and cytoskeletal remodeling in hiPSC-CMs deficient in PINK1

Huiwen Liu, Li Wang, Hao Xu, Bin Tan, Qin Yi, Hongrong Deng, Yunxia Chen, Bolin He, Jie Tian, Jing Zhu

Breast stiffness, a risk factor for cancer and the role of radiology for diagnosis

Sofia M. Tarchi, Monica Pernia Marin, Md. Murad Hossain, Mary Salvatore

RGS2 and female common diseases: a guard of women’s health

Qiang Xu, Mukun Yao, Chao Tang

Crush syndrome: a review for prehospital providers and emergency clinicians

Daisuke Usuda, Shintaro Shimozawa, Hiroki Takami, Yoshinobu Kako, Taigo Sakamoto, Junya Shimazaki, Junichi Inoue, Shinichi Nakayama, Yuichi Koido, Jiro Oba

New insights into the biology and development of lung cancer in never smokers—implications for early detection and treatment

Peiyao Wang, Sophie Sun, Stephen Lam, William W. Lockwood

Suppressive stroma-immune prognostic signature impedes immunotherapy in ovarian cancer and can be reversed by PDGFRB inhibitors

Dong Yang, Mei-Han Duan, Qiu-Er Yuan, Zhi-Ling Li, Chuang-Hua Luo, Lan-Yue Cui, Li-Chao Li, Ying Xiao, Xian-Ying Zhu, Hai-Liang Zhang, Gong-Kan Feng, Guo-Chen Liu, Rong Deng, Jun-Dong Li, Xiao-Feng Zhu

Interplay of chronic obstructive pulmonary disease and colorectal cancer development: unravelling the mediating role of fatty acids through a comprehensive multi-omics analysis

Youtao Zhou, Zikai Lin, Shuojia Xie, Yuan Gao, Haobin Zhou, Fengzhen Chen, Yuewu Fu, Cuiyan Yang, Chuanfeng Ke

Integrated machine learning survival framework develops a prognostic model based on inter-crosstalk definition of mitochondrial function and cell death patterns in a large multicenter cohort for lower-grade glioma

Hu Qin, Aimitaji Abulaiti, Aierpati Maimaiti, Zulihuma Abulaiti, Guofeng Fan, Yirizhati Aili, Wenyu Ji, Zengliang Wang, Yongxin Wang

Association between 5-year change in cardiovascular risk and the incidence of atherosclerotic cardiovascular diseases: a multi-cohort study

Jiayi Yi, Lili Wang, Xinli Guo, Xiangpeng Ren

STING signaling activation modulates macrophage polarization via CCL2 in radiation-induced lung injury

Jianjiao Ni, Tiantian Guo, Yue Zhou, Shanshan Jiang, Long Zhang, Zhengfei Zhu

Proteomic analysis unveils Gb3-independent alterations and mitochondrial dysfunction in a gla−/− zebrafish model of Fabry disease

Hassan Osman Alhassan Elsaid, Mariell Rivedal, Eleni Skandalou, Einar Svarstad, Camilla Tøndel, Even Birkeland, Øystein Eikrem, Janka Babickova, Hans-Peter Marti, Jessica Furriol

Osteonecrosis of the jaw induced by immune checkpoint inhibitors: an urgent need for attention

Xinya Li, Zaiwei Song, Rongsheng Zhao

BM-MSCs display altered gene expression profiles in B-cell acute lymphoblastic leukemia niches and exert pro-proliferative effects via overexpression of IFI6

Chengyun Pan, Tianzhen Hu, Ping Liu, Dan Ma, Shuyun Cao, Qin Shang, Luxin Zhang, Qingzhen Chen, Qin Fang, Jishi Wang

Micro-inflammation related gene signatures are associated with clinical features and immune status of fibromyalgia

Menghui Yao, Shuolin Wang, Yingdong Han, He Zhao, Yue Yin, Yun Zhang, Xuejun Zeng

RAS signaling and immune cells: a sinister crosstalk in the tumor microenvironment

Yongting Liu, Bin Xie, Qiong Chen

Ligand-based adoptive T cell targeting CA125 in ovarian cancer

Haihong Zhao, Lina Wu, Jiemin Dai, Ke Sun, Zhenguo Zi, Junhua Guan, Liwen Zhang

Cantharidin induces apoptosis of human triple negative breast cancer cells through mir-607-mediated downregulation of EGFR

Tianfeng Yang, Runze Yu, Cheng Cheng, Jian Huo, Zhengyan Gong, Hanbing Cao, Yu Hu, Bingling Dai, Yanmin Zhang

Application of radiomics-based multiomics combinations in the tumor microenvironment and cancer prognosis

Wendi Kang, Xiang Qiu, Yingen Luo, Jianwei Luo, Yang Liu, Junqing Xi, Xiao Li, Zhengqiang Yang

Non-spatial and spatial heterogeneity revealed a suppressive immune feature of Siglec-15 in lung adenocarcinomas

Baihui Li, Yan Guo, Yeran Yi, Ziqi Huang, Yulin Ren, Hao Wang, Lili Yang

CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity

Jiasheng Chen, Yuxin Lin, Shukai zheng, Qingshan Chen, Shijie Tang, Xiaoping Zhong

Cell-therapy for Parkinson’s disease: a systematic review and meta-analysis

Fang Wang, Zhengwu Sun, Daoyong Peng, Shikha Gianchandani, Weidong Le, Johannes Boltze, Shen Li

X-ray cross-complementing family: the bridge linking DNA damage repair and cancer

Qiang Liu, Qiu Peng, Bin Zhang, Yueqiu Tan

Diagnostic value of cerebrospinal fluid Neutrophil Gelatinase-Associated Lipocalin for differentiation of bacterial meningitis from tuberculous meningitis or cryptococcal meningitis: a prospective cohort study

Qi Wang, Qingwen Lin, Haiyan Wang, Minjie Tang, Kengna Fan, Zeqin Zhang, Er Huang, Weiqing Zhang, Fengqing Wang, Qishui Ou, Xiaofeng Liu

CUDC-907, a dual PI3K/histone deacetylase inhibitor, increases meta-iodobenzylguanidine uptake (123/131I-mIBG) in vitro and in vivo: a promising candidate for advancing theranostics in neuroendocrine tumors

Joana Grand-Guillaume, Rosalba Mansi, Raghuvir H. Gaonkar, Sandra Zanger, Melpomeni Fani, Philippe J. Eugster, Maja Beck Popovic, Eric Grouzmann, Karim Abid

ESRRG-PKM2 axis reprograms metabolism to suppress esophageal squamous carcinoma progression and enhance anti-PD-1 therapy efficacy

Tianxiao Wang, Yongjun Zhu, Lu Chen, WenXin Zhang, Huijie Qi, Xiaojin Shi, Mingkang Zhong, Haifei Chen, Qunyi Li

Antileukemic effect of venetoclax and hypomethylating agents via caspase-3/GSDME-mediated pyroptosis

Fanghua Ye, Wen Zhang, Chenying Fan, Jiajia Dong, Min Peng, Wenjun Deng, Hui Zhang, Liangchun Yang

Sildenafil, a phosphodiesterase-5 inhibitor, stimulates angiogenesis and bone regeneration in an atrophic non-union model in mice

Maximilian M. Menger, David Bauer, Michelle Bleimehl, Claudia Scheuer, Benedikt J. Braun, Steven C. Herath, Mika F. Rollmann, Michael D. Menger, Matthias W. Laschke, Tina Histing

Long-term outcomes of offspring from multiple gestations: a two-sample Mendelian randomization study on multi-system diseases using UK Biobank and FinnGen databases

Yi Jiang, Yuanyuan Du, Rui Su, Xuan Zhou, Lijie Wei, Jingyi Zhang, Shenglan Zhu, Huiting Zhang, Chenyun Fang, Yuting Chen, Peng Gao, Liangnan Zhang, Shaoshuai Wang, Jun Yu, Mengzhou He, Wencheng Ding, Ling Feng

Methods of ex vivo analysis of tissue status in vascularized composite allografts

Carolyn Ton, Sara Salehi, Sara Abasi, John R. Aggas, Renee Liu, Gerald Brandacher, Anthony Guiseppi-Elie, Warren L. Grayson

CD39 and LDHA affects the prognostic role of NLR in metastatic melanoma patients treated with immunotherapy

Domenico Mallardo, Mario Fordellone, Andrew White, Margaret Ottaviano, Francesca Sparano, Michael Bailey, Arianna Bianca Facchini, Sufey Ong, Piera Maiolino, Corrado Caracò, Sarah Church, Ernesta Cavalcanti, Sarah Warren, Alfredo Budillon, Alessandra Cesano, Ester Simeone, Paolo Chiodini, Paolo Antonio Ascierto

Establishment of a high-fidelity patient-derived xenograft model for cervical cancer enables the evaluation of patient’s response to conventional and novel therapies

Liting Liu, Min Wu, Anni Huang, Chun Gao, Yifan Yang, Hong Liu, Han Jiang, Long Yu, Yafei Huang, Hui Wang

Metastasis organotropism in colorectal cancer: advancing toward innovative therapies

Kai He, Zhihan Wang, Maochao Luo, Bowen Li, Ning Ding, Lei Li, Bo He, Han Wang, Jiangjun Cao, Canhua Huang, Jun Yang, Hai-Ning Chen

Mitochondrial dysfunction in neurodegenerative disorders: Potential therapeutic application of mitochondrial transfer to central nervous system-residing cells

Felipe A. Bustamante-Barrientos, Noymar Luque-Campos, María Jesús Araya, Eliana Lara-Barba, Javiera de Solminihac, Carolina Pradenas, Luis Molina, Yeimi Herrera-Luna, Yildy Utreras-Mendoza, Roberto Elizondo-Vega, Ana María Vega-Letter, Patricia Luz-Crawford

Tamoxifen exerts anti-peritoneal fibrosis effects by inhibiting H19-activated VEGFA transcription

Tingting Zhao, Zhengyu Sun, Xueli Lai, Hongtao Lu, Lulu Liu, Shuangxi Li, Ji-hang Yuan, Zhiyong Guo

Portraying the dark side of endogenous IFN-λ for promoting cancer progression and immunoevasion in pan-cancer

Zhen Zhen Wang, Xiao Ling Wen, Na Wang, Xu Hua Li, Yu Guo, Xu Zhu, Shu Heng Fu, Fei Fan Xiong, Jin Li, Limei Wang, Xiao Ling Gao, Hong Jiu Wang

Identification of potential drug targets for rheumatoid arthritis from genetic insights: a Mendelian randomization study

Yu Cao, Ying Yang, Qingfeng Hu, Guojun Wei

Vibrational spectroscopy identifies myocardial chemical modifications in heart failure with preserved ejection fraction

Leonardo Pioppi, Reza Parvan, Alan Samrend, Gustavo Jose Justo Silva, Marco Paolantoni, Paola Sassi, Alessandro Cataliotti

Exploration of the radiosensitivity-related prognostic risk signature in patients with glioma: evidence from microarray data

Xiaonan Zhang, Qiannan Ren, Zhiyong Li, Xiaolin Xia, Wan Zhang, Yue Qin, Dehua Wu, Chen Ren

Enhanced systemic tumor suppression by in situ vaccine combining radiation and OX40 agonist with CpG therapy

Zhichen Sun, Yanhong Chu, Jie Xiao, Yueling Yang, Fanyan Meng, Xinyue Wang, Yanbing Dong, Junmeng Zhu, Yirong Wu, Lanqun Qin, Yaohua Ke, Baorui Liu, Qin Liu

A diagnostic model for sepsis-induced acute lung injury using a consensus machine learning approach and its therapeutic implications

Yongxin Zheng, Jinping Wang, Zhaoyi Ling, Jiamei Zhang, Yuan Zeng, Ke Wang, Yu Zhang, Lingbo Nong, Ling Sang, Yonghao Xu, Xiaoqing Liu, Yimin Li, Yongbo Huang

Non-coding RNAs/DNMT3B axis in human cancers: from pathogenesis to clinical significance

Chunjie Huang, Paniz Azizi, Masoud Vazirzadeh, Seyed Mohsen Aghaei-Zarch, Fatemehsadat Aghaei-Zarch, Jalaledin Ghanavi, Poopak Farnia

Association between life’s essential 8 and biological ageing among US adults

Ronghuai Zhang, Min Wu, Wei Zhang, Xuna Liu, Jie Pu, Tao Wei, Zhanfang Zhu, Zhiguo Tang, Na Wei, Bo Liu, Qianwei Cui, Junkui Wang, Fuqiang Liu, Ying Lv

Function and mechanism of MCM8 in the development and progression of colorectal cancer

Shaojun Yu, Weixing Dai, Senlin Zhao, Yongzhi Yang, Ye Xu, Jianwei Wang, Qun Deng, Jinghu He, Debing Shi

Predictive performance of triglyceride glucose index (TyG index) to identify glucose status conversion: a 5-year longitudinal cohort study in Chinese pre-diabetes people

Xiaojie Chen, Danfeng Liu, Weiting He, Haofei Hu, Wenjian Wang

Arginine methylation of HSPA8 by PRMT9 inhibits ferroptosis to accelerate hepatitis B virus-associated hepatocellular carcinoma progression

Wensheng Deng, Jiaoyu Ai, Wanlin Zhang, Zhenyu Zhou, Muqi Li, Likun Yan, Lidong Zhang, Zongjing Huang, Ziyi Wu, Junhua Ai, Hai Jiang

Targeting FGFRs by pemigatinib induces G1 phase cell cycle arrest, cellular stress and upregulation of tumor suppressor microRNAs

Angelica Pace, Fabio Scirocchi, Chiara Napoletano, Ilaria Grazia Zizzari, Agnese Po, Francesca Megiorni, Angela Asquino, Paola Pontecorvi, Hassan Rahimi, Cinzia Marchese, Elisabetta Ferretti, Marianna Nuti, Aurelia Rughetti

SIRT1 activation promotes energy homeostasis and reprograms liver cancer metabolism

Benluvankar Varghese, Ugo Chianese, Lucia Capasso, Veronica Sian, Paola Bontempo, Mariarosaria Conte, Rosaria Benedetti, Lucia Altucci, Vincenzo Carafa, Angela Nebbioso

Identification of metabolism-related subtypes and feature genes in Alzheimer’s disease

Piaopiao Lian, Xing Cai, Cailin Wang, Ke Liu, Xiaoman Yang, Yi Wu, Zhaoyuan Zhang, Zhuoran Ma, Xuebing Cao, Yan Xu

Association of serum 25-hydroxyvitamin D levels with all-cause and cause-specific mortality among postmenopausal females: results from NHANES

Jia-Wei Shi, Jiang-Nan Wu, Xiao-Yong Zhu, Wen-Hui Zhou, Jin-Ying Yang, Ming-Qing Li

A novel NET-related gene signature for predicting DLBCL prognosis

Huizhong Shi, Yiming Pan, Guifen Xiang, Mingwei Wang, Yusong Huang, Liu He, Jue Wang, Qian Fang, Ling Li, Zhong Liu

Deep dissection of stemness-related hierarchies in hepatocellular carcinoma

Rui Liang, Weifeng Hong, Yang Zhang, Di Ma, Jinwei Li, Yisong Shi, Qing Luo, Shisuo Du, Guanbin Song

LAD1 promotes malignant progression by diminishing ubiquitin-dependent degradation of vimentin in gastric cancer

Yingming Jiang, Yanchun Feng, Jintuan Huang, Zhenze Huang, Rongchang Tan, Tuoyang Li, Zijian Chen, Xiaocheng Tang, Jun Qiu, Chujun Li, Hao Chen, Zuli Yang

Epstein–Barr virus-acquired immunodeficiency in myalgic encephalomyelitis—Is it present in long COVID?

Manuel Ruiz-Pablos, Bruno Paiva, Aintzane Zabaleta

Identification of novel first-trimester serum biomarkers for early prediction of preeclampsia

Mingxi Liu, Yue Niu, Kongyang Ma, Peter C. K. Leung, Zi-Jiang Chen, Daimin Wei, Yan Li

Mitochondrial dysfunction at the crossroad of cardiovascular diseases and cancer

Carmine Rocca, Teresa Soda, Ernestina Marianna De Francesco, Marco Fiorillo, Francesco Moccia, Giuseppe Viglietto, Tommaso Angelone, Nicola Amodio

Correction: Characterization of chimeric antigen receptor modified T cells expressing scFv-IL-13Rα2 after radiolabeling with 89Zirconium oxine for PET imaging

Pamela Leland, Dhiraj Kumar, Sridhar Nimmagadda, Steven R. Bauer, Raj K. Puri, Bharat H. Joshi

Immunologic constant of rejection as a predictive biomarker of immune checkpoint inhibitors efficacy in non-small cell lung cancer

Alice Mogenet, Pascal Finetti, Emilie Denicolai, Laurent Greillier, Pascaline Boudou-Rouquette, François Goldwasser, Gwenael Lumet, Michele Ceccarelli, Daniel Birnbaum, Davide Bedognetti, Emilie Mamessier, Fabrice Barlesi, François Bertucci, Pascale Tomasini

Transcriptome profiling of patient-derived tumor xenografts suggests novel extracellular matrix-related signatures for gastric cancer prognosis prediction

Ziqian Deng, Ting Guo, Jiwang Bi, Gangjian Wang, Ying Hu, Hong Du, Yuan Zhou, Shuqin Jia, Xiaofang Xing, Jiafu Ji

Brahma-related gene 1 acts as a profibrotic mediator and targeting it by micheliolide ameliorates peritoneal fibrosis

Shuting Li, Congwei Luo, Sijia Chen, Yiyi Zhuang, Yue Ji, Yiqun Zeng, Yao Zeng, Xiaoyang He, Jing Xiao, Huizhen Wang, Xiaowen Chen, Haibo Long, Fenfen Peng

Increased expression of OPN contributes to idiopathic pulmonary fibrosis and indicates a poor prognosis

Jie Ji, Shudan Zheng, Yuxin Liu, Tian Xie, Xiaoyu Zhu, Yang Nie, Yi Shen, Xiaodong Han

The heterogeneity and clonal evolution analysis of the advanced prostate cancer with castration resistance

Ao Liu, Yi Gao, Qi Wang, Wenhao Lin, Zhiyang Ma, Xiaoqun Yang, Lu Chen, Danfeng Xu

Perampanel’s forgiveness factor in a variable medication adherence paradigm in a rat model of chronic epilepsy

Michelle Guignet, Amanda Campbell, Jonathan Vuong, Dale Whittington, H. Steve White

Correlation of the tumor escape phenotype with loss of PRELP expression in melanoma

Helene Schäfer, Karthikeyan Subbarayan, Chiara Massa, Christoforos Vaxevanis, Anja Mueller, Barbara Seliger

Sirtuin1, not NAMPT, possesses anti-inflammatory effects in epicardial, pericardial and subcutaneous adipose tissue in patients with CHD

Trine Baur Opstad, Bianca Papotti, Sissel Åkra, Charlotte Holst Hansen, Bjørn Braathen, Theis Tønnessen, Svein Solheim, Ingebjørg Seljeflot

Neoadjuvant chemotherapy remodels the tumor immune microenvironment by increasing activated and cytotoxic T cell, decreasing B cells and macrophages in small cell lung cancer

Xiaoling Shang, Chenyue Zhang, Kai Wang, Haiyong Wang

Proteome-wide mendelian randomization study implicates therapeutic targets in common cancers

Feihong Ren, Qiubai Jin, Tongtong Liu, Xuelei Ren, Yongli Zhan

Characterization of tumor microenvironment and tumor immunology based on the double-stranded RNA-binding protein related genes in cervical cancer

Jin Li, Chong Wan, Xiaoqi Li, Chenlian Quan, Xiaoqiu Li, Xiaohua Wu

Identification of memory B-cell-associated miRNA signature to establish a prognostic model in gastric adenocarcinoma

Ruquan Liu, Biaojie Huang, Yongzhao Shao, Yongming Cai, Xi Liu, Zhonglu Ren

Integrating single-nucleus sequence profiling to reveal the transcriptional dynamics of Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis

Li-Yuan Fan, Jing Yang, Ruo-Yu Liu, Ying Kong, Guang-Yu Guo, Yu-Ming Xu

GMP-grade human neural progenitors delivered subretinally protect vision in rat model of retinal degeneration and survive in minipigs

Bin Lu, Pablo Avalos, Soshana Svendsen, Changqing Zhang, Laura Nocito, Melissa K. Jones, Cosmo Pieplow, Joshua Saylor, Sean Ghiam, Amanda Block, Michael Fernandez, Alexander V. Ljubimov, Kent Small, David Liao, Clive N. Svendsen, Shaomei Wang

Hypoxia-induced AFAP1L1 regulates pathological neovascularization via the YAP-DLL4-NOTCH axis

Jun-Song Ren, Wen Bai, Jing-Juan Ding, Hui-Min Ge, Su-Yu Wang, Xi Chen, Qin Jiang

FTO-targeted siRNA delivery by MSC-derived exosomes synergistically alleviates dopaminergic neuronal death in Parkinson's disease via m6A-dependent regulation of ATM mRNA

Yan Geng, Xinyi Long, Yuting Zhang, Yupeng Wang, Guoxing You, Wenjie Guo, Gaoming Zhuang, Yuanyuan Zhang, Xiao Cheng, Zhengqiang Yuan, Jie Zan

Transcriptional landscape of Kaposi sarcoma tumors identifies unique immunologic signatures and key determinants of angiogenesis

Ramya Ramaswami, Takanobu Tagawa, Guruswamy Mahesh, Anna Serquina, Vishal Koparde, Kathryn Lurain, Sarah Dremel, Xiaofan Li, Ameera Mungale, Alex Beran, Zoe Weaver Ohler, Laura Bassel, Andrew Warner, Ralph Mangusan, Anaida Widell, Irene Ekwede, Laurie T. Krug, Thomas S. Uldrick, Robert Yarchoan, Joseph M. Ziegelbauer

The application of HER2 and CD47 CAR-macrophage in ovarian cancer

Yizhao Chen, Xiangling Zhu, Hanze Liu, Cunzhi Wang, Yu Chen, Huihui Wang, Yilong Fang, Xuming Wu, Yuting Xu, Chunhua Li, Xinyue Lv, Jinghua Huang, Xintong Han, Ruilin Li, Wenming Hong, Zhiying Yu, Wei Wei, Jiajie Tu

Repurposing Metformin for periodontal disease management as a form of oral-systemic preventive medicine

Vitor C. M. Neves, Luciana Satie Okajima, Eyad Elbahtety, Susan Joseph, James Daly, Athul Menon, Di Fan, Ayste Volkyte, Giuseppe Mainas, Kathy Fung, Pawan Dhami, Andre A. Pelegrine, Paul Sharpe, Luigi Nibali, Mark Ide

Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression

Tao Liu, Meng-Qi Fan, Xiao-Xiao Xie, Qi-Peng Shu, Xue-Hua Du, Lin-Zhi Qi, Xiao-Dong Zhang, Ming-Hui Zhang, Guang Shan, Run-Lei Du, Shang-Ze Li

The effect of hyperthyroidism on cognitive function, neuroinflammation, and necroptosis in APP/PS1 mice

Kai Lou, Shudong Liu, Fengxia Zhang, Wenxiu Sun, Xinhuan Su, Wenkai Bi, Qingqing Yin, Yaxin Qiu, Zhenyuan Zhang, Mengzhe Jing, Shizhan Ma

Matched analysis of circulating selenium with the breast cancer selenotranscriptome: a multicentre prospective study

Kamil Demircan, Ylva Bengtsson, Thilo Samson Chillon, Johan Vallon-Christersson, Qian Sun, Christer Larsson, Martin Malmberg, Lao H. Saal, Lisa Rydén, Åke Borg, Jonas Manjer, Lutz Schomburg

LncRNA AC142119.1 facilitates the progression of neuroblastoma by epigenetically initiating the transcription of MYCN

Rui Yang, Nanjing Liu, Ting Li, Fangjie Liu, Jun Zhang, Hui Zhao, Lin Zou, Xiaoyan He

DNA methylation regulator-mediated modification patterns and risk of intracranial aneurysm: a multi-omics and epigenome-wide association study integrating machine learning, Mendelian randomization, eQTL and mQTL data

Aierpati Maimaiti, Mirzat Turhon, Aimitaji Abulaiti, Yilidanna Dilixiati, Fujunhui Zhang, Aximujiang Axieer, Kaheerman Kadeer, Yisen Zhang, Aisha Maimaitili, Xinjian Yang

Synovium is a sensitive tissue for mapping the negative effects of systemic iron overload in osteoarthritis: identification and validation of two potential targets

Zhuangzhuang Jin, He Zhang, Lunhao Bai, Lingyu Yue, Weiming Zhang, Jiajian Liang, Bohan Chang, Yue Yang, Zhehan Hu, Liang Chen, Chuanji Guo

Multi-omics analysis reveals attenuation of cellular stress by empagliflozin in high glucose-treated human cardiomyocytes

Lucia Scisciola, Ugo Chianese, Vicky Caponigro, Manuela Giovanna Basilicata, Emanuela Salviati, Lucia Altucci, Pietro Campiglia, Giuseppe Paolisso, Michelangela Barbieri, Rosaria Benedetti, Eduardo Sommella

Urinary peptides provide information about the risk of mortality across a spectrum of diseases and scenarios

Felix Keller, Joachim Beige, Justyna Siwy, Alexandre Mebazaa, Dewei An, Harald Mischak, Joost P. Schanstra, Marika Mokou, Paul Perco, Jan A. Staessen, Antonia Vlahou, Agnieszka Latosinska

Advancing polytrauma care: developing and validating machine learning models for early mortality prediction

Wen He, Xianghong Fu, Song Chen

Spotlights on ubiquitin-specific protease 12 (USP12) in diseases: from multifaceted roles to pathophysiological mechanisms

Kaiyi Niu, Yanlong Shi, Qingpeng Lv, Yizhu Wang, Jiping Chen, Wenning Zhang, Kung Feng, Yewei Zhang

Semiautomated pipeline for quantitative analysis of heart histopathology

Patrick Droste, Dickson W. L. Wong, Mathias Hohl, Saskia von Stillfried, Barbara M. Klinkhammer, Peter Boor

Tumor microenvironment in a minipig model of spinal cord glioma

Muhibullah S. Tora, Stewart G. Neill, Yuliya Lakhina, Hemza Assed, Michelle Zhang, Purva P. Nagarajan, Thais Federici, Juanmarco Gutierrez, Kimberly B. Hoang, Yuhong Du, Kecheng Lei, Nicholas M. Boulis

Romosozumab in osteoporosis: yesterday, today and tomorrow

Dong Wu, Lei Li, Zhun Wen, Guangbin Wang

Plant-based dietary patterns, genetic predisposition and risk of colorectal cancer: a prospective study from the UK Biobank

Fubin Liu, Yanling Lv, Yu Peng, Yating Qiao, Peng Wang, Changyu Si, Xixuan Wang, Jianxiao Gong, Huijun Zhou, Ming Zhang, Liangkai Chen, Fangfang Song

Intercellular adhesion molecule 2 as a novel prospective tumor suppressor induced by ERG promotes ubiquitination-mediated radixin degradation to inhibit gastric cancer tumorigenicity and metastasis

Xiaocheng Tang, Jintuan Huang, Yingming Jiang, Jun Qiu, Tuoyang Li, Weiyao Li, Zijian Chen, Zhenze Huang, Xihu Yu, Tao Yang, Xiang Ji, Rongchang Tan, Li lv, Zuli Yang, Hao Chen

Understanding the relationship between circulating lipids and risk of chronic kidney disease: a prospective cohort study and large-scale genetic analyses

Yutong Wang, Li Zhang, Wenqiang Zhang, Mingshuang Tang, Huijie Cui, Xueyao Wu, Xunying Zhao, Lin Chen, Peijing Yan, Chao Yang, Chenghan Xiao, Yanqiu Zou, Yunjie Liu, Ling Zhang, Chunxia Yang, Yuqin Yao, Jiayuan Li, Zhenmi Liu, Xia Jiang, Ben Zhang

B7H3-targeting chimeric antigen receptor modification enhances antitumor effect of Vγ9Vδ2 T cells in glioblastoma

Yi Wang, Nan Ji, Yang Zhang, Junsheng Chu, Changcun Pan, Peng Zhang, Weiwei Ma, Xueguang Zhang, Jianzhong Jeff Xi, Mingze Chen, Yonghui Zhang, Liwei Zhang, Tao Sun

Correction: Time- and cost-effective production of untagged recombinant MVA by flow virometry and direct virus sorting

Daniela Boselli, Maddalena Panigada, Simona Di Terlizzi, Monica Romanò, Emanuele Canonico, Chiara Villa, Claudia Minici, Eelco van Anken, Elisa Soprana, Antonio G. Siccardi

Genetic evidence strengthens the bidirectional connection between gut microbiota and periodontitis: insights from a two-sample Mendelian randomization study

Xinjian Ye, Bin Liu, Yijing Bai, Yue Cao, Sirui Lin, Linshuoshuo Lyu, Haohao Meng, Yuwei Dai, Ding Ye, Weiyi Pan, Zhiyong Wang, Yingying Mao, Qianming Chen

Adherence to the Mediterranean diet as a possible additional tool to be used for screening the metabolically unhealthy obesity (MUO) phenotype

Luigi Barrea, Ludovica Verde, Daniel Simancas-Racines, Ana Karina Zambrano, Evelyn Frias-Toral, Annamaria Colao, Silvia Savastano, Giovanna Muscogiuri

Tyrosine phosphorylation of band 3 impairs the storage quality of suspended red blood cells in the Tibetan high-altitude polycythemia population

Xiaodong Wu, Zhijuan Liu, Doudou Hao, Qin Zhao, Wanjing Li, Maodi Xie, Xia Feng, Xia Liao, Siyuan Chen, Siyu Wang, Chaohua Zhou, Wenchun Long, Yajun Zhong, Shen Li, Ye Cao, Hong Wang, Aiping Wang, Yuehong Xu, Min Huang, Jiaxin Liu, Rui Zhong, Yunhong Wu, Zeng He

Translational process

Marina Boccardi

MicroRNA-125a-5p regulates the effect of Tregs on Th1 and Th17 through targeting ETS-1/STAT3 in psoriasis

Kexiang Yan, Fuxin Zhang, Jie Ren, Qiong Huang, Nikhil Yawalkar, Ling Han

Cytosine–phosphate–guanine oligodeoxynucleotides alleviate radiation-induced kidney injury in cervical cancer by inhibiting DNA damage and oxidative stress through blockade of PARP1/XRCC1 axis

Deyu Zhang, Shitai Zhang, Zheng He, Ying Chen

Simultaneous diagnosis of tuberculous pleurisy and malignant pleural effusion using metagenomic next-generation sequencing (mNGS)

Fudong Xu, Qingfeng Wang, Nana Zhang, Xuya Xing, Zichen Liu, Kun Li, Yutong Ma, Qiuxiang Ou, Yaqiong Jia, Xuejing Chen, Chen Zhang, Junhua Pan, Nanying Che

Genetically proxied antidiabetic drugs targets and stroke risk

Yahui Zhu, Mao Li, Hongfen Wang, Fei Yang, Xinyuan Pang, Rongrong Du, Jinghong Zhang, Xusheng Huang

Tyrosine kinase signaling-independent MET-targeting with CAR-T cells

Anna Qin, Yuan Qin, Joseph Lee, Anna Musket, Mingyao Ying, Giedre Krenciute, Francesco M. Marincola, Zhi Q. Yao, Phillip R. Musich, Qian Xie

The addition of anlotinib reduces the incidence of radiation and immunotherapy-induced pneumonia

Linlin Yang, Qian Zhao, Jinming Yu, Linlin Wang

Association of diabetes risk reduction diet with renal cancer risk in 101,755 participants: a prospective study

Ling Xiang, Yi Xiao, Zhiquan Xu, Haoyun Luo, Xiaorui Ren, Qi Wei, Zhiyong Zhu, Yahui Jiang, Yunhao Tang, Hongmei He, Zhihang Zhou, Haitao Gu, Yaxu Wang, Linglong Peng

Preoperative fluorescence in situ hybridization analysis as a predictor of tumor recurrence in patients with non-muscle invasive bladder cancer: a bi-institutional study

Junjiong Zheng, Sihong Lu, Yi Huang, Xu Chen, Jie Zhang, Yuhui Yao, Jinhua Cai, Jieying Wu, Jianqiu Kong, Tianxin Lin

Exploring the dynamic interplay between cancer stem cells and the tumor microenvironment: implications for novel therapeutic strategies

Yan-Ruide Li, Ying Fang, Zibai Lyu, Yichen Zhu, Lili Yang

A comparison of laboratory-based and office-based Framingham risk scores to predict 10-year risk of cardiovascular diseases: a population-based study

Azizallah Dehghan, Sajjad Ahmadnia Motlagh, Rozhan Khezri, Fatemeh Rezaei, Dagfinn Aune

Potent antitumor efficacy of human dental pulp stem cells armed with YSCH-01 oncolytic adenovirus

Xu He, Wei Yao, Ji-Ding Zhu, Xin Jin, Xin-Yuan Liu, Kang-Jian Zhang, Shou-Liang Zhao

The gut microbiome tango in the progression of chronic kidney disease and potential therapeutic strategies

Zijing Tang, Shiyan Yu, Yu Pan

Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity

Chia Yee Tan, Pui Shi Chan, Hansen Tan, Sung Wei Tan, Chang Jie Mick Lee, Jiong-Wei Wang, Shu Ye, Hendrikje Werner, Ying Jie Loh, Yin Loon Lee, Matthew Ackers-Johnson, Roger S. Y. Foo, Jianming Jiang

Association between systemic immune-inflammation index and metabolic syndrome and its components: results from the National Health and Nutrition Examination Survey 2011–2016

Yang Zhao, Wenyu Shao, Qihan Zhu, Rui Zhang, Tao Sun, Bijia Wang, Xiaofei Hu

Very-low-calorie ketogenic diet vs hypocaloric balanced diet in the prevention of high-frequency episodic migraine: the EMIKETO randomized, controlled trial

Massimiliano Caprio, Eleonora Moriconi, Elisabetta Camajani, Alessandra Feraco, Vincenzo Marzolla, Laura Vitiello, Stefania Proietti, Andrea Armani, Stefania Gorini, Caterina Mammi, Gabriella Egeo, Cinzia Aurilia, Giulia Fiorentini, Carlo Tomino, Piero Barbanti

Mechanisms and research advances in mRNA antibody drug-mediated passive immunotherapy

Yuxiang Zhao, Linchuan Gan, Dangjin Ke, Qi Chen, Yajuan Fu

Antibody against apolipoprotein-A1, non-alcoholic fatty liver disease and cardiovascular risk: a translational study

Sabrina Pagano, Stephan J. L. Bakker, Catherine Juillard, Stefania Vossio, Dimitri Moreau, Karim J. Brandt, François Mach, Robin P. F. Dullaart, Nicolas Vuilleumier

TRPA1 promotes cisplatin-induced acute kidney injury via regulating the endoplasmic reticulum stress-mitochondrial damage

Fei Deng, Heping Zhang, Wei Zhou, Shijie Ma, Yuwei Kang, Wei Yang, Liangbin Zhao, Wei Qin

Mitochondrial heteroplasmic shifts reveal a positive selection of breast cancer

Yanni Li, Kristina Sundquist, Sakshi Vats, Mun-Gwan Hong, Xiao Wang, Yilun Chen, Anna Hedelius, Lao H. Saal, Jan Sundquist, Ashfaque A. Memon

Periodontitis is associated with stroke

Xiaodan Zheng, Xin Li, Juanying Zhen, Dai Xue, Jun Hu, Qing Cao, Aimin Xu, Bernard Man Yung Cheung, Jun Wu, Chao Li

Real-time detection of laryngopharyngeal cancer using an artificial intelligence-assisted system with multimodal data

Yun Li, Wenxin Gu, Huijun Yue, Guoqing Lei, Wenbin Guo, Yihui Wen, Haocheng Tang, Xin Luo, Wenjuan Tu, Jin Ye, Ruomei Hong, Qian Cai, Qingyu Gu, Tianrun Liu, Beiping Miao, Ruxin Wang, Jiangtao Ren, Wenbin Lei

Causal relationships of circulating amino acids with cardiovascular disease: a trans-ancestry Mendelian randomization analysis

Song Hu, Zhennan Lin, Meng-Jin Hu, Jiang-Shan Tan, Ting-Ting Guo, Xin Huang, Lu Hua

Novel role for epalrestat: protecting against NLRP3 inflammasome-driven NASH by targeting aldose reductase

Wei Shi, Guang Xu, Yuan Gao, Jun Zhao, Tingting Liu, Jia Zhao, Huijie Yang, Ziying Wei, Hui Li, An-Long Xu, Zhaofang Bai, Xiaohe Xiao

Knockdown of NR3C1 inhibits the proliferation and migration of clear cell renal cell carcinoma through activating endoplasmic reticulum stress–mitophagy

Minbo Yan, Jinhua Wang, Haojie Wang, Jun Zhou, Hao Qi, Yaser Naji, Liangyu Zhao, Yuxin Tang, Yingbo Dai

Immunization with a multi-antigen targeted DNA vaccine eliminates chemoresistant pancreatic cancer by disrupting tumor-stromal cell crosstalk

Hongquan Qin, Jiali Chen, Katia Bouchekioua-Bouzaghou, Ya-Ming Meng, Jordi Bach Griera, Xue Jiang, Xiangzhan Kong, Minghui Wang, Qiuping Xu, Ping-Pui Wong

Fibrosis and bone marrow: understanding causation and pathobiology

Kanjaksha Ghosh, Durjoy K. Shome, Bipin Kulkarni, Malay K. Ghosh, Kinjalka Ghosh

Fusobacterium nucleatum upregulates MMP7 to promote metastasis-related characteristics of colorectal cancer cell via activating MAPK(JNK)-AP1 axis

Suwen Ou, Haipeng Chen, Hufei Wang, Jinhua Ye, Huidi Liu, Yangbao Tao, Songlin Ran, Xiaoqin Mu, Fangzhou Liu, Shuang Zhu, Kangjia Luo, Zilong Guan, Yinghu Jin, Rui Huang, Yanni Song, Shu-lin Liu

The association of moderate-to-vigorous physical activity and sedentary behaviour with abdominal aortic calcification

Chang Sheng, Weihua Huang, Wei Wang, Guoqiang Lin, Mingmei Liao, Pu Yang

The complexity of nicotinamide adenine dinucleotide (NAD), hypoxic, and aryl hydrocarbon receptor cell signaling in chronic kidney disease

Colleen S. Curran, Jeffrey B. Kopp

Neuroplastin exerts antiepileptic effects through binding to the α1 subunit of GABA type A receptors to inhibit the internalization of the receptors

Sijun Li, Xing Wei, Hongmi Huang, Lin Ye, Meigang Ma, Lanfeng Sun, Yuling Lu, Yuan Wu

Tissue fibrosis induced by radiotherapy: current understanding of the molecular mechanisms, diagnosis and therapeutic advances

Zuxiang Yu, Chaoyu Xu, Bin Song, Shihao Zhang, Chong Chen, Changlong Li, Shuyu Zhang

Genomic communication via circulating extracellular vesicles and long-term health consequences of COVID-19

Soumyalekshmi Nair, Estefania Nova-Lamperti, Gonzalo Labarca, Arutha Kulasinghe, Kirsty R. Short, Flavio Carrión, Carlos Salomon

CD22 is a potential target of CAR-NK cell therapy for esophageal squamous cell carcinoma

Tingdang Liu, Ximing Dai, Yien Xu, Tian Guan, Liangli Hong, Tahir Zaib, Qi Zhou, Ke Cheng, Xiaoling Zhou, Changchun Ma, Pingnan Sun

Matrix stiffness induces Drp1-mediated mitochondrial fission through Piezo1 mechanotransduction in human intervertebral disc degeneration

Wencan Ke, Bingjin Wang, Zhiwei Liao, Yu Song, Gaocai Li, Liang Ma, Kun Wang, Shuai Li, Wenbin Hua, Cao Yang

Insights into the liver-eyes connections, from epidemiological, mechanical studies to clinical translation

Junhao Wu, Caihan Duan, Yuanfan Yang, Zhe Wang, Chen Tan, Chaoqun Han, Xiaohua Hou

Characterization of endoplasmic reticulum stress unveils ZNF703 as a promising target for colorectal cancer immunotherapy

Hufei Wang, Zhi Li, Yangbao Tao, Suwen Ou, Jinhua Ye, Songlin Ran, Kangjia Luo, Zilong Guan, Jun Xiang, Guoqing Yan, Yang Wang, Tianyi Ma, Shan Yu, Yanni Song, Rui Huang

Prediction of clinically significant prostate cancer through urine metabolomic signatures: A large-scale validated study

Hsiang-Po Huang, Chung-Hsin Chen, Kai-Hsiung Chang, Ming-Shyue Lee, Cheng-Fan Lee, Yen-Hsiang Chao, Shih-Yu Lu, Tzu-Fan Wu, Sung-Tzu Liang, Chih-Yu Lin, Yuan Chi Lin, Shih-Ping Liu, Yu-Chuan Lu, Chia-Tung Shun, William J. Huang, Tzu-Ping Lin, Ming-Hsuan Ku, Hsiao-Jen Chung, Yen-Hwa Chang, Chun-Hou Liao, Chih-Chin Yu, Shiu-Dong Chung, Yao-Chou Tsai, Chia-Chang Wu, Kuan-Chou Chen, Chen-Hsun Ho, Pei-Wen Hsiao, Yeong-Shiau Pu

Myeloid PTP1B deficiency protects against atherosclerosis by improving cholesterol homeostasis through an AMPK-dependent mechanism

Helk Oliver, Dekeryte Ruta, Dawn Thompson, Sarah Kamli-Salino, Sam Philip, Heather M. Wilson, Nimesh Mody, Mirela Delibegovic

Dissecting transcription of the 8q24-MYC locus in prostate cancer recognizes the equilibration between androgen receptor direct and indirect dual-functions

Ju Guo, Zhao Wei, Tianwei Jia, Liyang Wang, Nuosu Nama, Jiaqian Liang, Xinghua Liao, Xiaming Liu, Yanfei Gao, Xiaoqiang Liu, Keshan Wang, Bin Fu, Shaoyong Shawn Chen

Increased co-expression of PD1 and TIM3 is associated with poor prognosis and immune microenvironment heterogeneity in gallbladder cancer

Xing He, Yaorong Peng, Gui He, Huilin Ye, Liqiang Liu, Qixian Zhou, Juanyi Shi, Sha Fu, Jie Wang, Zhenyu Zhou, Wenbin Li

Association between HMGCR, CRP, and CETP gene polymorphisms and metabolic/inflammatory serum profile in healthy adolescents

Benedetta Perrone, Paola Ruffo, Giuseppina Augimeri, Diego Sisci, Maria Stefania Sinicropi, Giovanni Tripepi, Corrado Mammì, Daniela Bonofiglio, Francesca Luisa Conforti

Molecular mechanism of vimentin nuclear localization associated with the migration and invasion of daughter cells derived from polyploid giant cancer cells

Linlin Fan, Minying Zheng, Xinyue Zhou, Yongjun Yu, Yidi Ning, Wenzheng Fu, Jing Xu, Shiwu Zhang

A scoping review of ‘Pacing’ for management of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): lessons learned for the long COVID pandemic

Nilihan E. M. Sanal-Hayes, Marie Mclaughlin, Lawrence D. Hayes, Jacqueline L. Mair, Jane Ormerod, David Carless, Natalie Hilliard, Rachel Meach, Joanne Ingram, Nicholas F. Sculthorpe

Cancer stem cell-derived CHI3L1 activates the MAF/CTLA4 signaling pathway to promote immune escape in triple-negative breast cancer

Shufeng Ji, Hao Yu, Dan Zhou, Xulong Fan, Yan Duan, Yijiang Tan, Min Lang, Guoli Shao

Bidirectional Mendelian randomization analysis of the genetic association between primary lung cancer and colorectal cancer

Zhihan Xiao, Zichen Wang, Tongyu Zhang, Yi Liu, Mingxuan Si

Adipose stromal cells bioproducts as cell-free therapies: manufacturing and therapeutic dose determine in vitro functionality

Renata Skovronova, Eleonora Scaccia, Sandra Calcat-i-Cervera, Benedetta Bussolati, Timothy O’Brien, Karen Bieback

Cardiovascular and microvascular outcomes according to vitamin D level and genetic variants among individuals with prediabetes: a prospective study

Pingting Zhong, Zhuoting Zhu, Yunlong Wang, Wenyong Huang, Mingguang He, Wei Wang

The Molecular Tumor Board of the Regina Elena National Cancer Institute: from accrual to treatment in real-world

Patrizio Giacomini, Fabio Valenti, Matteo Allegretti, Matteo Pallocca, Francesca De Nicola, Ludovica Ciuffreda, Maurizio Fanciulli, Stefano Scalera, Simonetta Buglioni, Elisa Melucci, Beatrice Casini, Mariantonia Carosi, Edoardo Pescarmona, Elena Giordani, Francesca Sperati, Nicoletta Jannitti, Martina Betti, Marcello Maugeri-Saccà, Fabiana Letizia Cecere, Veronica Villani, Andrea Pace, Marialuisa Appetecchia, Patrizia Vici, Antonella Savarese, Eriseld Krasniqi, Virginia Ferraresi, Michelangelo Russillo, Alessandra Fabi, Lorenza Landi, Gabriele Minuti, Federico Cappuzzo, Massimo Zeuli, Gennaro Ciliberto

Personalized radiomics signature to screen for KIT-11 mutation genotypes among patients with gastrointestinal stromal tumors: a retrospective multicenter study

Qing-Wei Zhang, Ran-Ying Zhang, Zhi-Bo Yan, Yu-Xuan Zhao, Xin-Yuan Wang, Jing-Zheng Jin, Qi-Xuan Qiu, Jie-Jun Chen, Zhen-Hui Xie, Jiang Lin, Hui Cao, Yan Zhou, Hui-Min Chen, Xiao-Bo Li

KDeep: a new memory-efficient data extraction method for accurately predicting DNA/RNA transcription factor binding sites

Saeedeh Akbari Rokn Abadi, SeyedehFatemeh Tabatabaei, Somayyeh Koohi

Harnessing large language models (LLMs) for candidate gene prioritization and selection

Mohammed Toufiq, Darawan Rinchai, Eleonore Bettacchioli, Basirudeen Syed Ahamed Kabeer, Taushif Khan, Bishesh Subba, Olivia White, Marina Yurieva, Joshy George, Noemie Jourde-Chiche, Laurent Chiche, Karolina Palucka, Damien Chaussabel

Acellular ex vivo lung perfusate silences pro-inflammatory signaling in human lung endothelial and epithelial cells

Jamie E. Jeon, Lei Huang, Zhiyuan Zhu, Aaron Wong, Shaf Keshavjee, Mingyao Liu

Genetic assessment of pathogenic germline alterations in lysosomal genes among Asian patients with pancreatic ductal adenocarcinoma

Youngil Koh, Hyemin Kim, So Young Joo, Seulki Song, Young Hoon Choi, Hyung Rae Kim, Byul Moon, Jamin Byun, Junshik Hong, Dong-Yeop Shin, Solip Park, Kwang Hyuck Lee, Kyu Taek Lee, Jong Kyun Lee, Daechan Park, Se-Hoon Lee, Jin-Young Jang, Hyunsook Lee, Jung-Ae Kim, Sung-Soo Yoon, Joo Kyung Park

A novel deep learning-based algorithm combining histopathological features with tissue areas to predict colorectal cancer survival from whole-slide images

Yan-Jun Li, Hsin-Hung Chou, Peng-Chan Lin, Meng-Ru Shen, Sun-Yuan Hsieh

The HIFIA/LINC02913/IGF1R axis promotes the cell function of adipose-derived mesenchymal stem cells under hypoxia via activating the PI3K/AKT pathway

Xiang Xiong, Liqin Yuan, Kai Yang, Xiancheng Wang

Neurotrophin-3 promotes peripheral nerve regeneration by maintaining a repair state of Schwann cells after chronic denervation via the TrkC/ERK/c-Jun pathway

Xiong Xu, Lili Song, Yueying Li, Jin Guo, Shuo Huang, Shuang Du, Weizhen Li, Rangjuan Cao, Shusen Cui

Deciphering intratumoral heterogeneity of hepatocellular carcinoma with microvascular invasion with radiogenomic analysis

Yi Wang, Gui-Qi Zhu, Rui Yang, Cheng Wang, Wei-Feng Qu, Tian-Hao Chu, Zheng Tang, Chun Yang, Li Yang, Chang-Wu Zhou, Geng-Yun Miao, Wei-Ren Liu, Ying-Hong Shi, Meng-Su Zeng

The potential role of reprogrammed glucose metabolism: an emerging actionable codependent target in thyroid cancer

Sai-li Duan, Min Wu, Zhe-Jia Zhang, Shi Chang

RIZ2 at the crossroad of the EGF/EGFR signaling in colorectal cancer

Marzia Di Donato, Erika Di Zazzo, Annamaria Salvati, Carmela Sorrentino, Giorgio Giurato, Donatella Fiore, Maria Chiara Proto, Monica Rienzo, Amelia Casamassimi, Patrizia Gazzerro, Maurizio Bifulco, Gabriella Castoria, Alessandro Weisz, Giovanni Nassa, Ciro Abbondanza

BRAF D594A mutation defines a unique biological and immuno-modulatory subgroup associated with functional CD8+ T cell infiltration in colorectal cancer

Wenjing Li, Chenyi Zhao, Wenhui Li, Yang Gong, Kaili Ma, Yujie Lu, Xiaowei Liu, Lianjun Zhang, Feng Guo

Targeting RPA promotes autophagic flux and the antitumor response to radiation in nasopharyngeal carcinoma

Yanchun Feng, Yingming Jiang, Jun Liu, Jiaqi Liu, Mengchen Shi, Junxiong Chen, Jingdan Zhang, Yu Tian, Xiangling Yang, Huanliang Liu

Insulin-induced gene 2 protects against hepatic ischemia–reperfusion injury via metabolic remodeling

Yichao Wu, Changbiao Li, Abid Ali Khan, Kangchen Chen, Renyi Su, Shengjun Xu, Yiyang Sun, Fengqiang Gao, Kai Wang, Xiaodong Wang, Zhengxing Lian, Shuo Wang, Mengyuan Yu, Xin Hu, Fan Yang, Shusen Zheng, Nasha Qiu, Zhikun Liu, Xiao Xu

Washed microbiota transplantation improves renal function in patients with renal dysfunction: a retrospective cohort study

Hao-Jie Zhong, Xinqiang Xie, Wen-Jia Chen, Yu-Pei Zhuang, Xuan Hu, Ying-Li Cai, Hong-Lie Zeng, Chuanxing Xiao, Ying Li, Yu Ding, Liang Xue, Moutong Chen, Jumei Zhang, Qingping Wu, Xing-Xiang He

ALKBH5 enhances lipid metabolism reprogramming by increasing stability of FABP5 to promote pancreatic neuroendocrine neoplasms progression in an m6A-IGF2BP2-dependent manner

Jinhao Chen, Mujie Ye, Jianan Bai, Zhihui Gong, Lijun Yan, Danyang Gu, Chunhua Hu, Feiyu Lu, Ping Yu, Lin Xu, Yan Wang, Ye Tian, Qiyun Tang

Circulating miR-133a-3p defines a low-risk subphenotype in patients with heart failure and central sleep apnea: a decision tree machine learning approach

David de Gonzalo-Calvo, Pablo Martinez-Camblor, Thalia Belmonte, Ferran Barbé, Kevin Duarte, Martin R. Cowie, Christiane E. Angermann, Andrea Korte, Isabelle Riedel, Josephine Labus, Wolfgang Koenig, Faiez Zannad, Thomas Thum, Christian Bär

Myeloperoxidase and its negative relationship with cholesterol efflux capacity in patients with psoriasis: results from an observational cohort study

Elizabeth M. Florida, Haiou Li, J. Rodante, H. L. Teague, Martin P. Playford

Sarcopenia and myosteatosis diagnostic tool for gastrointestinal cancer: creatinine to cystatin C ratio as evaluation marker

Hao Liu, Junjie Wang, Shanjun Tan, Zhige Zhang, Mingyue Yan, Jun Han, Xiangyu Sui, Fan Yang, Guohao Wu

Elesclomol, a copper-transporting therapeutic agent targeting mitochondria: from discovery to its novel applications

Mojtaba Tarin, Maryam Babaie, Hossein Eshghi, Maryam M. Matin, Amir Sh. Saljooghi

CRISPR/Cas9 technology: applications in oocytes and early embryos

Yi-ran Zhang, Tai-lang Yin, Li-quan Zhou

miR-100a-5p-enriched exosomes derived from mesenchymal stem cells enhance the anti-oxidant effect in a Parkinson’s disease model via regulation of Nox4/ROS/Nrf2 signaling

Songzhe He, Qiongqiong Wang, Liankuai Chen, Yusheng Jason He, Xiaofang Wang, Shaogang Qu

One episode of low intensity aerobic exercise prior to systemic AAV9 administration augments transgene delivery to the heart and skeletal muscle

Christina A. Pacak, Silveli Suzuki-Hatano, Fatemeh Khadir, Audrey L. Daugherty, Mughil Sriramvenugopal, Bennett J. Gosiker, Peter B. Kang, William Todd Cade

Preventive and therapeutic opportunities: targeting BAP1 and/or HMGB1 pathways to diminish the burden of mesothelioma

Michele Carbone, Michael Minaai, Yasutaka Takinishi, Ian Pagano, Haining Yang

Trajectory patterns of metabolic syndrome severity score and risk of type 2 diabetes

Atieh Amouzegar, Mohammadjavad Honarvar, Safdar Masoumi, Davood Khalili, Fereidoun Azizi, Ladan Mehran

Decoding meningioma heterogeneity and neoplastic cell—macrophage interaction through single-cell transcriptome profiling across pathological grades

Hailang Fan, Lairong Song, Jian Fan, Junpeng Ma, Xiaojie Li, Junting Zhang, Jian Hu, Zhen Wu, Dake Zhang, Liang Wang

JMJD6–BRD4 complex stimulates lncRNA HOTAIR transcription by binding to the promoter region of HOTAIR and induces radioresistance in liver cancer stem cells

Ruifeng Pei, Le Zhao, Yiren Ding, Zhan Su, Deqiang Li, Shuo Zhu, Lu Xu, Wei Zhao, Wuyuan Zhou

The role of diabetes in metastatic melanoma patients treated with nivolumab plus relatlimab

Domenico Mallardo, Rachel Woodford, Alexander M. Menzies, Lisa Zimmer, Andrew williamson, Egle Ramelyte, Florentia Dimitriou, Alexandre Wicky, Roslyn Wallace, Mario Mallardo, Alessio Cortellini, Alfredo Budillon, Victoria Atkinson, Shahneen Sandhu, Michielin Olivier, Reinhard Dummer, Paul Lorigan, Dirk Schadendorf, Georgina V. Long, Ester Simeone, Paolo A. Ascierto

Fasting mimicking diet inhibits tumor-associated macrophage survival and pro-tumor function in hypoxia: implications for combination therapy with anti-angiogenic agent

Lei Wang, Yu-jie Wang, Rong Wang, Fu-lian Gong, Yu-huan Shi, Sheng-nan Li, Pan-pan Chen, Yong-fang Yuan

Scientific evidence supporting the newly developed one-health labeling tool “Med-Index”: an umbrella systematic review on health benefits of mediterranean diet principles and adherence in a planeterranean perspective

Roberta Zupo, Fabio Castellana, Prisco Piscitelli, Pasquale Crupi, Addolorata Desantis, Enrico Greco, Franca Paola Severino, Manuela Pulimeno, Andrea Guazzini, Tassos C. Kyriakides, Vasilis Vasiliou, Antonia Trichopoulou, Laura Soldati, Carlo La Vecchia, Giovanni De Gaetano, Maria Benedetta Donati, Annamaria Colao, Alessandro Miani, Filomena Corbo, Maria Lisa Clodoveo

Mitochondrial modulation with leriglitazone as a potential treatment for Rett syndrome

Uliana Musokhranova, Cristina Grau, Cristina Vergara, Laura Rodríguez-Pascau, Clara Xiol, Alba A. Castells, Soledad Alcántara, Pilar Rodríguez-Pombo, Pilar Pizcueta, Marc Martinell, Angels García-Cazorla, Alfonso Oyarzábal

Inflammatory signaling in NASH driven by hepatocyte mitochondrial dysfunctions

Melissa Myint, Francesca Oppedisano, Valeria De Giorgi, Byeong-Moo Kim, Francesco M. Marincola, Harvey J. Alter, Salvatore Nesci

HCG18, LEF1AS1 and lncCEACAM21 as biomarkers of disease severity in the peripheral blood mononuclear cells of COVID-19 patients

Simona Greco, Alisia Made’, Martina Mutoli, Lu Zhang, Santiago Nicolas Piella, Mélanie Vausort, Andrew I. Lumley, Antonio Paolo Beltrami, Prashant Kumar Srivastava, Valentina Milani, Sara Boveri, Marco Ranucci, Laura Valentina Renna, Hüseyin Firat, Antonino Bruno, Gaia Spinetti, Costanza Emanueli, Yvan Devaux, Fabio Martelli

Unfolded protein response pathways in stroke patients: a comprehensive landscape assessed through machine learning algorithms and experimental verification

Haiyang Yu, Xiaoyu Ji, Yang Ouyang

Spatiotemporal evolution of AML immune microenvironment remodeling and RNF149-driven drug resistance through single-cell multidimensional analysis

Xin Wu, Zhongguang Wu, Woding Deng, Rong Xu, Chunmei Ban, Xiaoying Sun, Qiangqiang Zhao

Integration of machine learning to identify diagnostic genes in leukocytes for acute myocardial infarction patients

Lin Zhang, Yue Liu, Kaiyue Wang, Xiangqin Ou, Jiashun Zhou, Houliang Zhang, Min Huang, Zhenfang Du, Sheng Qiang

Clinical evaluation of metagenomic next-generation sequencing in unbiased pathogen diagnosis of urinary tract infection

Ye Wang, Ting Chen, Shengwei Zhang, Lei Zhang, Qian Li, Qingyu Lv, Decong Kong, Hua Jiang, Yuhao Ren, Yongqiang Jiang, Yan Li, Wenhua Huang, Peng Liu

Evaluation of viral infection as an etiology of ME/CFS: a systematic review and meta-analysis

Jae-Hyun Hwang, Jin-Seok Lee, Hyeon-Muk Oh, Eun-Jung Lee, Eun-Jin Lim, Chang-Gue Son

Meningioma animal models: a systematic review and meta-analysis

Mikkel Schou Andersen, Mikkel Seremet Kofoed, Asger Sand Paludan-Müller, Christian Bonde Pedersen, Tiit Mathiesen, Christian Mawrin, Martin Wirenfeldt, Bjarne Winther Kristensen, Birgitte Brinkmann Olsen, Bo Halle, Frantz Rom Poulsen

Efficacy of IVIG therapy for patients with sepsis: a systematic review and meta-analysis

Bo Pan, Pan Sun, Renjun Pei, Fangzhao Lin, Haijun Cao

Identification of RECK as a protective prognostic indicator and a tumor suppressor through regulation of the ERK/MAPK signaling pathway in gastric cancer

Fangyuan Qi, Yaru Wang, Bingxin Yu, Fan Li

“Emergency” multidisciplinary team meeting in cancer: a first feedback from a care team

Henri-Corto Stoeklé, David Billard, Jaafar Bennouna, Philippe Beuzeboc, Christian Hervé

Multipredictor risk models for predicting individual risk of Alzheimer’s disease

Xiao-He Hou, John Suckling, Xue-Ning Shen, Yong Liu, Chuan-Tao Zuo, Yu-Yuan Huang, Hong-Qi Li, Hui-Fu Wang, Chen-Chen Tan, Mei Cui, Qiang Dong, Lan Tan, Jin-Tai Yu

The important role of miR-1-3p in cancers

Shangming Dai, Fengjiao Li, Shuoguo Xu, Jinda Hu, Lichen Gao

Lycium barbarum glycopeptide alleviates neuroinflammation in spinal cord injury via modulating docosahexaenoic acid to inhibiting MAPKs/NF-kB and pyroptosis pathways

Zhanfeng Jiang, Zhong Zeng, He He, Mei Li, Yuanxiang Lan, Jianwen Hui, Pengfei Bie, Yanjun Chen, Hao Liu, Heng Fan, Hechun Xia

Changes of immune microenvironment in head and neck squamous cell carcinoma in 3D-4-culture compared to 2D-4-culture

Jian Xiao, Yexun Song, Ru Gao, Mingyang You, Changxin Deng, Guolin Tan, Wei Li

Network medicines™

Joyce Hu

KRASG12C inhibition using MRTX1257: a novel radio-sensitizing partner

Pierre-Antoine Laurent, Marina Milic, Clément Quevrin, Lydia Meziani, Winchygn Liu, Daphné Morel, Nicolas Signolle, Céline Clémenson, Antonin Levy, Michele Mondini, Eric Deutsch

Role of m6A modification in regulating the PI3K/AKT signaling pathway in cancer

Jie Liu, Xinyu Gu, Zhenjie Guan, Di Huang, Huiwu Xing, Lian Zheng

Genetic risk factors for severe and fatigue dominant long COVID and commonalities with ME/CFS identified by combinatorial analysis

Krystyna Taylor, Matthew Pearson, Sayoni Das, Jason Sardell, Karolina Chocian, Steve Gardner

Elevated phospholipids and acylcarnitines C4 and C5 in cerebrospinal fluid distinguish viral CNS infections from autoimmune neuroinflammation

Amani Al-Mekhlafi, Fakhar H. Waqas, Maike Krueger, Frank Klawonn, Manas K. Akmatov, Kirsten Müller-Vahl, Corinna Trebst, Thomas Skripuletz, Martin Stangel, Kurt-Wolfram Sühs, Frank Pessler

Deciphering the molecular and cellular atlas of immune cells in septic patients with different bacterial infections

Ping Sun, Mintian Cui, Jiongjie Jing, Fanyu Kong, Shixi Wang, Lunxian Tang, Junling Leng, Kun Chen

LncRNA-Gm9866 promotes liver fibrosis by activating TGFβ/Smad signaling via targeting Fam98b

Xiaomin Liao, Xianxian Ruan, Peishan Yao, Dan Yang, Xianbin Wu, Xia Zhou, Jie Jing, Dafu Wei, Yaodan Liang, Taicheng Zhang, Shanyu Qin, Haixing Jiang

Exploring the efficacy and beneficial population of preimplantation genetic testing for aneuploidy start from the oocyte retrieval cycle: a real-world study

Shujuan Ma, Jingnan Liao, Shuoping Zhang, Xiaoyi Yang, Berthold Hocher, Jing Tan, Yueqiu Tan, Liang Hu, Fei Gong, Pingyuan Xie, Ge Lin

Anaplastic thyroid cancer cells reduce CD71 levels to increase iron overload tolerance

Simona D’Aprile, Simona Denaro, Anna Maria Pavone, Sebastiano Giallongo, Cesarina Giallongo, Alfio Distefano, Lucia Salvatorelli, Filippo Torrisi, Raffaella Giuffrida, Stefano Forte, Daniele Tibullo, Giovanni Li Volti, Gaetano Magro, Nunzio Vicario, Rosalba Parenti

Advanced glycation end products impair bone marrow mesenchymal stem cells osteogenesis in periodontitis with diabetes via FTO-mediated N6-methyladenosine modification of sclerostin

Jie Zhou, Yanlin Zhu, Dongqing Ai, Mengjiao Zhou, Han Li, Guangyue Li, Leilei Zheng, Jinlin Song

Integrated machine learning identifies epithelial cell marker genes for improving outcomes and immunotherapy in prostate cancer

Weian Zhu, Hengda Zeng, Jiongduan Huang, Jianjie Wu, Yu Wang, Ziqiao Wang, Hua Wang, Yun Luo, Wenjie Lai

Deep neural network based tissue deconvolution of circulating tumor cell RNA

Fengyao Yan, Limin Jiang, Fei Ye, Jie Ping, Tetiana Y. Bowley, Scott A. Ness, Chung-I Li, Dario Marchetti, Jijun Tang, Yan Guo

Unveiling the dynamics of the breast milk microbiome: impact of lactation stage and gestational age

Parul Singh, Noora Al Mohannadi, Selvasankar Murugesan, Fajr Almarzooqi, Basirudeen Syed Ahamed Kabeer, Alexandra Katharina Marr, Tomoshige Kino, Tobias Brummaier, Annalisa Terranegra, Rose McGready, François Nosten, Damien Chaussabel, Souhaila Al Khodor

LncRNA-XR_002792574.1-mediated ceRNA network reveals potential biomarkers in myopia-induced retinal ganglion cell damage

Xuejun Wang, Qinghong Lin, Shengtao Liu, Xiaoying Li, Xiehe Kong, Yuliang Wang, Weijung Ten, Yangyi Huang, Yanting Yang, Jing Zhao, Xiaopeng Ma, Xingtao Zhou

Precision medicine in nasopharyngeal carcinoma: comprehensive review of past, present, and future prospect

Pui Yan Siak, Win Sen Heng, Sharon Siew Hoon Teoh, Yu Yu Lwin, Shiau-Chuen Cheah

The characteristics and the multiple functions of integrin β1 in human cancers

Li Sun, Shuwei Guo, Yiping Xie, Yongliang Yao

A multi-task deep learning model for EGFR genotyping prediction and GTV segmentation of brain metastasis

Zichun Zhou, Min Wang, Rubin Zhao, Yan Shao, Ligang Xing, Qingtao Qiu, Yong Yin

Integrative multi-omics analysis unveils stemness-associated molecular subtypes in prostate cancer and pan-cancer: prognostic and therapeutic significance

Kun Zheng, Youlong Hai, Yue Xi, Yukun Zhang, Zheqi Liu, Wantao Chen, Xiaoyong Hu, Xin Zou, Jie Hao

Systematic analysis of various RNA transcripts and construction of biological regulatory networks at the post-transcriptional level for chronic obstructive pulmonary disease

Beibei Li, Jiajun Zhang, Hui Dong, Xueyan Feng, Liang Yu, Jinyuan Zhu, Jin Zhang

Multimeric immunotherapeutic complexes activating natural killer cells towards HIV-1 cure

Rafaëla Schober, Bianca Brandus, Thessa Laeremans, Gilles Iserentant, Camille Rolin, Géraldine Dessilly, Jacques Zimmer, Michel Moutschen, Joeri L. Aerts, Xavier Dervillez, Carole Seguin-Devaux

Enhancing nasopharyngeal carcinoma cell radiosensitivity by suppressing AKT/mTOR via CENP-N knockdown

Li-Zhi Wu, You Zou, Bin-Ru Wang, Hai-Feng Ni, Yong-Gang Kong, Qing-Quan Hua, Shi-Ming Chen

Muc2 mucin o-glycosylation interacts with enteropathogenic Escherichia coli to influence the development of ulcerative colitis based on the NF-kB signaling pathway

Juan Wei, Chunyan Chen, Jing Feng, Shuping Zhou, Xiaoyue Feng, Zhao Yang, Heng Lu, Hui Tao, Liuying Li, Huabing Xv, Ji Xuan, Fangyu Wang

Unraveling temporal and spatial biomarkers of epithelial-mesenchymal transition in colorectal cancer: insights into the crucial role of immunosuppressive cells

Muhong Wang, Chunyu Deng, Cheng Yang, Mingze Yan, Haibo Lu, Yan Zhang, Honghao Liu, Zhekuan Tong, Jiaao Ma, Jiaming Wang, Yan Zhang, Jiahao Wang, Yuhong Xuan, Haiyue Cheng, Kai Zhao, Jiaqi Zhang, Cuicui Chai, Mingzhe Li, Zhiwei Yu

The role of germanium in diseases: exploring its important biological effects

Xiao Luo, Jiaxue Sun, Deshenyue Kong, Yi Lei, Fangyou Gong, Tong Zhang, Zongwen Shen, Kunhua Wang, Huayou Luo, Yu Xu

Repurposing dimethyl fumarate as an antiepileptogenic and disease-modifying treatment for drug-resistant epilepsy

Sereen Sandouka, Prince Kumar Singh, Aseel Saadi, Rhoda Olowe Taiwo, Yara Sheeni, Taige Zhang, Larin Deeb, Michelle Guignet, Steve H. White, Tawfeeq Shekh-Ahmad

ID1 and IGFBP3: roles in cellular senescence, cardiac development, angiogenesis and cancer diagnosis

Cheng Shen

Nomogram prediction of the 70-gene signature (MammaPrint) binary and quartile categorized risk using medical history, imaging features and clinicopathological data among Chinese breast cancer patients

Bo Pan, Ying Xu, Ru Yao, Xi Cao, Xingtong Zhou, Zhixin Hao, Yanna Zhang, Changjun Wang, Songjie Shen, Yanwen Luo, Qingli Zhu, Xinyu Ren, Lingyan Kong, Yidong Zhou, Qiang Sun

Pharmacological inhibition of the cysteine protease cathepsin C improves graft function after heart transplantation in rats

Baoer Liu, Brice Korkmaz, Patricia Kraft, Tobias Mayer, Alex A. Sayour, Marc A. Grundl, Roxane Domain, Matthias Karck, Gábor Szabó, Sevil Korkmaz-Icöz

Leveraging circulating microbiome signatures to predict tumor immune microenvironment and prognosis of patients with non-small cell lung cancer

Xiaohan Zhou, Liting You, Zhaodan Xin, Huiting Su, Juan Zhou, Ying Ma

System analysis based on the pyroptosis-related genes identifes GSDMD as a novel therapy target for skin cutaneous melanoma

Shixin Zhao, Yongkang Zhu, Hengdeng Liu, Xuefeng He, Julin Xie

Human Wharton’s jelly-derived mesenchymal stromal cells promote bone formation in immunodeficient mice when administered into a bone microenvironment

Raquel Cabrera-Pérez, Alexis Ràfols-Mitjans, Ángela Roig-Molina, Silvia Beltramone, Joaquim Vives, Laura Batlle-Morera

CD4+CCR8+ Tregs in ovarian cancer: a potential effector Tregs for immune regulation

Shuna Liu, Ziqi Tao, Jianfang Lou, Rong Li, Xin Fu, Juan Xu, Ting Wang, Lei Zhang, Wenwen Shang, Yepeng Mao, Fang Wang

Increased risk of chronic fatigue syndrome following infection: a 17-year population-based cohort study

Hsun Chang, Chien-Feng Kuo, Teng-Shun Yu, Liang-Yin Ke, Chung-Lieh Hung, Shin-Yi Tsai

Establishment and application of the BRP prognosis model for idiopathic pulmonary fibrosis

Xiaoyun Cheng, Zhichao Feng, Boyu Pan, Qingxiang Liu, Yuanyuan Han, Lijun Zou, Pengfei Rong, Jie Meng

Impact of statin treatment on cardiovascular risk in patients with type 1 diabetes: a population-based cohort study

Joonsang Yoo, Jimin Jeon, Minyoul Baek, Sun Ok Song, Jinkwon Kim

USP39 interacts with SIRT7 to promote cervical squamous cell carcinoma by modulating autophagy and oxidative stress via FOXM1

Juanpeng Yu, Shuai Yuan, Jinglin Song, Shengsheng Yu

The current status and future of ADC therapy for small cell Lung Cancer: a promising approach

Jiawei Zhou, Peiwen Ma, Qiyu Tang, Shuhang Wang, Ning Li

Liquid-based biomarkers in breast cancer: looking beyond the blood

You Shuai, Zhonghua Ma, Jie Ju, Tong Wei, Songlin Gao, Yikun Kang, Zixuan Yang, Xue Wang, Jian Yue, Peng Yuan

Insights into the regulatory role of RNA methylation modifications in glioma

Shengrong Long, Yu Yan, Hongyu Xu, Lesheng Wang, Jiazhi Jiang, Ziyue Xu, Runming Liu, Qiangqiang Zhou, Xiaopeng Huang, Jincao Chen, Zhiqiang Li, Wei Wei, Xiang Li

Notch-based gene signature for predicting the response to neoadjuvant chemotherapy in triple-negative breast cancer

Mohamed Omar, Pier Vitale Nuzzo, Francesco Ravera, Sara Bleve, Giuseppe Nicolò Fanelli, Claudio Zanettini, Itzel Valencia, Luigi Marchionni

A novel two-step administration of XPO-1 inhibitor may enhance the effect of anti-BCMA CAR-T in relapsed/refractory extramedullary multiple myeloma

Di Wang, Haiying Fu, Yimei Que, Haitao Ruan, Menglei Xu, Xiaolu Long, Qiuxia Yu, Chunhui Li, Zhe Li, Songbai Cai, Wei Chen, Cong Sun, Guang Hu, Shuai Wang, Donggou He, Jianming Mei, Wen Wang, Chunrui Li

The radio-induced immune response: ballistics is key

Céline Mirjolet, Jérémy Baude

Dysautonomia and small fiber neuropathy in post-COVID condition and Chronic Fatigue Syndrome

N. Azcue, R. Del Pino, M. Acera, T. Fernández-Valle, N. Ayo-Mentxakatorre, T. Pérez-Concha, A. Murueta-Goyena, J. V. Lafuente, A. Prada, A. López de Munain, G. Ruiz Irastorza, D. Martín-Iglesias, L. Ribacoba, I. Gabilondo, J. C. Gómez-Esteban, B. Tijero-Merino

Macrophage metabolism, phenotype, function, and therapy in hepatocellular carcinoma (HCC)

Jingquan Huang, Qiulin Wu, David A. Geller, Yihe Yan

Characteristics of vaginal microbiota in various cervical intraepithelial neoplasia: a cross-sectional study

Yiran Liu, Shuzhen Wang, Jun Liu, Mingrui Su, Xiaoli Diao, Xiaolong Liang, Jianxin Zhang, Qiuxi Wang, Yuxin Zhan

HOXD9/miR-451a/PSMB8 axis is implicated in the regulation of cell proliferation and metastasis via PI3K/AKT signaling pathway in human anaplastic thyroid carcinoma

Yong Zhong, Fan Yu, Ling Yang, Yu Wang, Lin Liu, Chengyou Jia, Haidong Cai, Jianshe Yang, Shiyang Sheng, Zhongwei Lv, Li Weng, Bo Wu, Xiaoping Zhang

The impact of fibrotic diseases on global mortality from 1990 to 2019

Henricus A. M. Mutsaers, Camilla Merrild, Rikke Nørregaard, Oleguer Plana-Ripoll

PTPRH promotes the progression of non-small cell lung cancer via glycolysis mediated by the PI3K/AKT/mTOR signaling pathway

Shu Wang, Zhiming Cheng, Yan Cui, Shuoyan Xu, Qiu Luan, Shan Jing, Bulin Du, Xuena Li, Yaming Li

YAP1/Piezo1 involve in the dynamic changes of lymphatic vessels in UVR-induced photoaging progress to squamous cell carcinoma

Yuling L. Yang, Chu Zhou, Qi Chen, Shuzhan Z. Shen, Jiandan D. Li, Xiuli L. Wang, Peiru R. Wang

A role of TRIM59 in pulmonary hypertension: modulating the protein ubiquitylation modification

Yingli Liu, Li Zhu, Yue Ming, Zhuhua Wu, Lili Zhang, Qi Chen, Yong Qi

Assessing the causal effect of genetically predicted metabolites and metabolic pathways on stroke

Tianlong Zhang, Yina Cao, Jianqiang Zhao, Jiali Yao, Gang Liu

WGX50 mitigates doxorubicin-induced cardiotoxicity through inhibition of mitochondrial ROS and ferroptosis

Panpan Tai, Xinyu Chen, Guihua Jia, Guanjun Chen, Lian Gong, Yaxin Cheng, Zhuan Li, Heng Wang, Aiyan Chen, Ganghua Zhang, Yuxing Zhu, Mengqing Xiao, Zhanwang Wang, Yunqing Liu, Dongyong Shan, Dong He, Moying Li, Tianzuo Zhan, Abbas Khan, Xiaohui Li, Xiangxiang Zeng, Chaopeng Li, Dongsheng Ouyang, Kelong Ai, Xuan Chen, Dongbo Liu, Zhonghua Liu, Dongqing Wei, Ke Cao

Profiling the metabolic disorder and detection of colorectal cancer based on targeted amino acids metabolomics

Yang Yang, Zhipeng Wang, Xinxing Li, Jianfeng Lv, Renqian Zhong, Shouhong Gao, Feng Zhang, Wansheng Chen

Long read sequencing characterises a novel structural variant, revealing underactive AKR1C1 with overactive AKR1C2 as a possible cause of severe chronic fatigue

Julia Oakley, Martin Hill, Adam Giess, Mélanie Tanguy, Greg Elgar

Palmitoylation landscapes across human cancers reveal a role of palmitoylation in tumorigenesis

Yue Kong, Yugeng Liu, Xianzhe Li, Menglan Rao, Dawei Li, Xiaolan Ruan, Shanglin Li, Zhenyou Jiang, Qiang Zhang

Crosstalk and plasticity driving between cancer-associated fibroblasts and tumor microenvironment: significance of breast cancer metastasis

Wenfeng Zhang, Jia Wang, Cun Liu, Ye Li, Changgang Sun, Jibiao Wu, Qibiao Wu

IL-17A promotes tumorigenesis and upregulates PD-L1 expression in non-small cell lung cancer

Hua Liao, Xiaodan Chang, Lin Gao, Cuiping Ye, Yujie Qiao, Lingyan Xie, Jie Lin, Shaoxi Cai, Hangming Dong

Mechanism and treatment of olfactory dysfunction caused by coronavirus disease 2019

Bian Hu, Mengdan Gong, Yizhen Xiang, Siyuan Qu, Hai Zhu, Dong Ye

Advancing personalized medicine in brain cancer: exploring the role of mRNA vaccines

Feng Lin, Emma Z. Lin, Misa Anekoji, Thomas E. Ichim, Joyce Hu, Francesco M. Marincola, Lawrence D. Jones, Santosh Kesari, Shashaanka Ashili

Oral microbiota disorder in GC patients revealed by 2b-RAD-M

Shengfu He, Yating Sun, Weijie Sun, Mingyang Tang, Bao Meng, Yanyan Liu, Qinxiang Kong, Yongxiang Li, Jiawen Yu, Jiabin Li

Pretreatment of UC-MSCs with IFN-α2 improves treatment of liver fibrosis by recruiting neutrophils

Ye Xie, Jia Yao, Mengchao Yan, Yan Lin, Jiayun Wei, Haiping Wang, Yongcui Mao, Pinyan Liu, Xun Li

Transcription factor LHX9 (LIM Homeobox 9) enhances pyruvate kinase PKM2 activity to induce glycolytic metabolic reprogramming in cancer stem cells, promoting gastric cancer progression

Hongying Zhao, Rongke Jiang, Zhijing Feng, Xue Wang, Chunmei Zhang

Sex differences in the association between plasma polyunsaturated fatty acids levels and moderate-to-severe plaque psoriasis severity: a cross-sectional and longitudinal study

Xin Wang, Rui Ma, Rongcan Shi, Hui Qin, Wenjuan Chen, Zengyang Yu, Yangfeng Ding, Chen Peng, Yuling Shi

Neutrophil-to-lymphocyte ratio (NLR) predicts mortality in hospitalized geriatric patients independent of the admission diagnosis: a multicenter prospective cohort study

Mirko Di Rosa, Jacopo Sabbatinelli, Luca Soraci, Andrea Corsonello, Anna Rita Bonfigli, Antonio Cherubini, Riccardo Sarzani, Roberto Antonicelli, Giuseppe Pelliccioni, Roberta Galeazzi, Francesca Marchegiani, Salvatore Iuorio, Daniele Colombo, Maurizio Burattini, Fabrizia Lattanzio, Fabiola Olivieri

Classification of tumor types using XGBoost machine learning model: a vector space transformation of genomic alterations

Veronica Zelli, Andrea Manno, Chiara Compagnoni, Rasheed Oyewole Ibraheem, Francesca Zazzeroni, Edoardo Alesse, Fabrizio Rossi, Claudio Arbib, Alessandra Tessitore

Real-world data suggest effectiveness of the allogeneic mesenchymal stromal cells preparation MSC-FFM in ruxolitinib-refractory acute graft-versus-host disease

Halvard Bonig, Mareike Verbeek, Peter Herhaus, Krischan Braitssch, Gernot Beutel, Christoph Schmid, Nadine Müller, Gesine Bug, Michaela Döring, Arend von Stackelberg, Johanna Tischer, Francis Ayuk, Gerald Wulf, Udo Holtick, Lisa-Marie Pfeffermann, Bernd Jahrsdörfer, Hubert Schrezenmeier, Selim Kuci, Zyrafete Kuci, Anke Zens, Michael Tribanek, Robert Zeiser, Sabine Huenecke, Peter Bader

LIPH contributes to glycolytic phenotype in pancreatic ductal adenocarcinoma by activating LPA/LPAR axis and maintaining ALDOA stability

Lijie Han, Yongsheng Jiang, Minmin Shi, Lina Gan, Zhichong Wu, Meilin Xue, Youwei Zhu, Cheng Xiong, Ting Wang, Xiaozhu Lin, Baiyong Shen, Lingxi Jiang, Hao Chen

Myrislignan targets extracellular signal-regulated kinase (ERK) and modulates mitochondrial function to dampen osteoclastogenesis and ovariectomy-induced osteoporosis

Tao Yang, Weiwei Chen, Kai Gan, Chaofeng Wang, Xiaoxiao Xie, Yuangang Su, Haoyu Lian, Jiake Xu, Jinmin Zhao, Qian Liu

A novel intronic circular RNA circFGFR1int2 up-regulates FGFR1 by recruiting transcriptional activators P65/FUS and suppressing miR-4687-5p to promote prostate cancer progression

Ruyue Wang, Jinjing Zhong, Xiuyi Pan, Zhengzheng Su, Yunyi Xu, Mengni Zhang, Xueqin Chen, Ni Chen, Ting Yu, Qiao Zhou

Biological underpinnings of radiomic magnetic resonance imaging phenotypes for risk stratification in IDH wild-type glioblastoma

Fangzhan Guan, Zilong Wang, Yuning Qiu, Yu Guo, Dongling Pei, Minkai Wang, Aoqi Xing, Zhongyi Liu, Bin Yu, Jingliang Cheng, Xianzhi Liu, Yuchen Ji, Dongming Yan, Jing Yan, Zhenyu Zhang

Improving the therapeutic efficacy of oncolytic viruses for cancer: targeting macrophages

Zhen Shen, Xiyu Liu, Guixiang Fan, Jintong Na, Qiaoqiao Liu, Faquan Lin, Zhikun Zhang, Liping Zhong

Talniflumate abrogates mucin immune suppressive barrier improving efficacy of gemcitabine and nab-paclitaxel treatment in pancreatic cancer

Antonio Agostini, Ilaria Guerriero, Geny Piro, Giuseppe Quero, Luca Roberto, Annachiara Esposito, Alessia Caggiano, Lorenzo Priori, Giulia Scaglione, Francesco De Sanctis, Antonella Sistigu, Martina Musella, Alberto Larghi, Gianenrico Rizzatti, Donatella Lucchetti, Sergio Alfieri, Alessandro Sgambato, Emilio Bria, Laura Bizzozero, Sabrina Arena, Stefano Ugel, Vincenzo Corbo, Giampaolo Tortora, Carmine Carbone

Parathyroid hormone stimulates bone regeneration in an atrophic non-union model in aged mice

Maximilian M. Menger, Anne L. Tobias, David Bauer, Michelle Bleimehl, Claudia Scheuer, Michael D. Menger, Tina Histing, Matthias W. Laschke

Altered m6A RNA methylation governs denervation-induced muscle atrophy by regulating ubiquitin proteasome pathway

Junjie Sun, Hai Zhou, Zehao Chen, Han Zhang, Yanzhe Cao, Xinlei Yao, Xin Chen, Boya Liu, Zihui Gao, Yuntian Shen, Lei Qi, Hualin Sun

Complement factor H attenuates TNF-α-induced inflammation by upregulating EIF3C in rheumatoid arthritis

Yimeng Jia, Bin Feng, Xin Ji, Xinping Tian, Lidan Zhao, Jiaxin Zhou, Wen Zhang, Mengtao Li, Yunyun Fei, Xunyao Wu

TIE1 and TEK signalling, intraocular pressure, and primary open-angle glaucoma: a Mendelian randomization study

Skanda Rajasundaram, Nazlee Zebardast, Puja Mehta, Anthony P. Khawaja, Alasdair Warwick, Katherine Duchinski, Stephen Burgess, Dipender Gill, Ayellet V. Segrè, Janey Wiggs

A Bayesian spatio-temporal study of the association between meteorological factors and the spread of COVID-19

Jamie D. Mullineaux, Baptiste Leurent, Takoua Jendoubi

Automatic generation of alloreactivity-reduced donor lymphocytes and hematopoietic stem cells from the same mobilized apheresis product

E. Wiercinska, P. Quade-Lyssy, C. Hümmer, J. Beifuß, K. Akarkach, C. Poppe, V. Olevska, J. Dzionek, H. Lahnor, A. Bosio, E. Papanikolaou, Halvard Bonig

CircTENM3 inhibites tumor progression via the miR-558/RUNX3 axis in prostate cancer

Lingxiang Lu, Fei Wang, Jianchun Chen, Chunchun Zhao, Shuai Guo, Da Dong, Minjun Jiang, Yuhua Huang

Radiogenomic analysis of cellular tumor-stroma heterogeneity as a prognostic predictor in breast cancer

Ming Fan, Kailang Wang, You Zhang, Yuanyuan Ge, Zhong Lü, Lihua Li

Paneth cell-derived iNOS is required to maintain homeostasis in the intestinal stem cell niche

Lingxiao Huang, Zhenni Xu, Xudan Lei, Yujun Huang, Siyu Tu, Lu Xu, Jieying Xia, Dengqun Liu

Clinical application of calcium silicate-based bioceramics in endodontics

Xinyuan Wang, Yizhi Xiao, Wencheng Song, Lanxiang Ye, Chen Yang, Yuzhen Xing, Zhenglin Yuan

LncRNA TDRKH-AS1 promotes breast cancer progression via the miR-134-5p/CREB1 axis

Yuqin Ding, Yuting Huang, Fanrong Zhang, Lijie Gong, Chenlu Liang, Kaijing Ding, Xiangming He, Xiaowen Ding, Yiding Chen

METTL3-mediated HOTAIRM1 promotes vasculogenic mimicry icontributionsn glioma via regulating IGFBP2 expression

Zhangyi Wu, Nan Wei

Research on radiotherapy related genes and prognostic target identification of rectal cancer based on multi-omics

Yi Liu, Yanguang Yang, Feng Ni, Guomei Tai, Cenming Yu, Xiaohui Jiang, Ding Wang

Hypoxia-inducible factor 1α modulates interstitial pneumonia-mediated lung cancer progression

Kiyofumi Shimoji, Taku Nakashima, Takeshi Masuda, Masashi Namba, Shinjiro Sakamoto, Kakuhiro Yamaguchi, Yasushi Horimasu, Takahiro Mimae, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Morihito Okada, Noboru Hattori

The novel norcantharidin derivative DCZ5417 suppresses multiple myeloma progression by targeting the TRIP13–MAPK–YWHAE signaling pathway

Yingcong Wang, Sanfeng Dong, Ke Hu, Li Xu, Qilin Feng, Bo Li, Guangli Wang, Gege Chen, Bibo Zhang, Xinyan Jia, Zhijian Xu, Xuejie Gao, Hui Zhang, Yongsheng Xie, Meiling Lu, Shuaikang Chang, Dongliang Song, Xiaosong Wu, Qi Jia, Huabin Zhu, Jinfeng Zhou, Weiliang Zhu, Jumei Shi

The construction of a testis transcriptional cell atlas from embryo to adult reveals various somatic cells and their molecular roles

Najmeh Salehi, Mehdi Totonchi

Metabolomic profiles of intact tissues reflect clinically relevant prostate cancer subtypes

Ilona Dudka, Kristina Lundquist, Pernilla Wikström, Anders Bergh, Gerhard Gröbner

hnRNPA2B1 promotes the occurrence and progression of hepatocellular carcinoma by downregulating PCK1 mRNA via a m6A RNA methylation manner

Weijie Hao, Zhimin Chen, Jingzhi Tang, Ru Yang, Wei-Qiang Gao, Huiming Xu

Identification and characterization of ARID1A-interacting proteins in renal tubular cells and their molecular regulation of angiogenesis

Sunisa Yoodee, Paleerath Peerapen, Sirikanya Plumworasawat, Thanyalak Malaitad, Visith Thongboonkerd

The promoting effect and mechanism of MAD2L2 on stemness maintenance and malignant progression in glioma

Zhiyuan Liu, Songtao Wang, Kuo Yu, Kaile Chen, Liang Zhao, Jiayue Zhang, Kexiang Dai, Peng Zhao

A novel complement-fixing IgM antibody targeting GPC1 as a useful immunotherapeutic strategy for the treatment of pancreatic ductal adenocarcinoma

Davide Busato, Sara Capolla, Paolo Durigutto, Monica Mossenta, Sara Bozzer, Daniele Sblattero, Paolo Macor, Michele Dal Bo, Giuseppe Toffoli

C–C chemokine receptor 5 is essential for conventional NK cell trafficking and liver injury in a murine hepatitis virus-induced fulminant hepatic failure model

Yun-Hui Liu, Lin Zhu, Zhong-Wei Zhang, Ting-Ting Liu, Qiu-Yu Cheng, Meng Zhang, Yu-Xin Niu, Lin Ding, Wei-Ming Yan, Xiao-Ping Luo, Qin Ning, Tao Chen

SIX1 amplification modulates stemness and tumorigenesis in breast cancer

Liantao Guo, Faminzi Li, Hanqing Liu, Deguang Kong, Chuang Chen, Shengrong Sun

Targeting epidermal growth factor receptor to recruit newly generated neuroblasts in cortical brain injuries

Ricardo Gómez-Oliva, Noelia Geribaldi-Doldán, Samuel Domínguez-García, Ricardo Pardillo-Díaz, Sergio Martínez-Ortega, José M. Oliva-Montero, Patricia Pérez-García, Francisco J. García-Cózar, Juan P. Muñoz-Miranda, Ismael Sánchez-Gomar, Pedro Nunez-Abades, Carmen Castro

Triglyceride to high-density lipoprotein cholesterol ratio is associated with regression to normoglycemia from prediabetes in adults: a 5-year cohort study in China

Zhiqiang Huang, Yong Han, Haofei Hu, Changchun Cao, Dehong Liu, Zhibin Wang

Inhibitory receptor CD47 binding to plasma TSP1 suppresses NK-cell IFN-γ production via activating the JAK/STAT3 pathway during HIV infection

Bin Lang, Meiting Wang, Zining Zhang, Yajing Fu, Xiaoxu Han, Qinghai Hu, Haibo Ding, Hong Shang, Yongjun Jiang

Association of vitamin B2 intake with cognitive performance in older adults: a cross-sectional study

Lingyan Zhou

Low-density lipoprotein receptor promotes crosstalk between cell stemness and tumor immune microenvironment in breast cancer: a large data-based multi-omics study

Qihang Yuan, Xiaona Lu, Hui Guo, Jiaao Sun, Mengying Yang, Quentin Liu, Mengying Tong

TP53 missense mutation reveals gain-of-function properties in small-sized KRAS transformed pancreatic ductal adenocarcinoma

Yiran Zhou, Jiabin Jin, Yuchen Ji, Jiaqiang Zhang, Ningzhen Fu, Mengmin Chen, Jun Wang, Kai Qin, Yu Jiang, Dongfeng Cheng, Xiaxing Deng, Baiyong Shen

A comparative study on ctDNA and tumor DNA mutations in lung cancer and benign cases with a high number of CTCs and CTECs

Jianzhu Xie, Binjie Hu, Yanping Gong, Sijia He, Jun Lin, Qian Huang, Jin Cheng

The enrichment of Fanconi anemia/homologous recombination pathway aberrations in ATM/ATR-mutated NSCLC was accompanied by unique molecular features and poor prognosis

Wei Wei, Fangfang Shi, Yang Xu, Yang Jiao, Ying Zhang, Qiuxiang Ou, Xue Wu, Lingyi Yang, Jinhuo Lai

A postmortem case control study of asbestos burden in lungs of malignant mesothelioma cases

S. D. Visonà, B. Bertoglio, C. Favaron, S. Capella, E. Belluso, C. Colosio, S. Villani, T. Ivic-Pavlicic, E. Taioli

Tigecycline causes loss of cell viability mediated by mitochondrial OXPHOS and RAC1 in hepatocellular carcinoma cells

Dominik T. Koch, Haochen Yu, Iris Beirith, Malte Schirren, Moritz Drefs, Yunfei Liu, Mathilda Knoblauch, Dionysios Koliogiannis, Weiwei Sheng, Enrico N. De Toni, Alexandr V. Bazhin, Bernhard W. Renz, Markus O. Guba, Jens Werner, Matthias Ilmer

ND630 controls ACACA and lipid reprogramming in prostate cancer by regulating the expression of circKIF18B_003

Yu-Peng Wu, Wen-Cai Zheng, Qi Huang, Xu-Yun Huang, Fei Lin, Zhi-Bin Ke, Qi You, Qing-Shui Zheng, Yong Wei, Xue-Yi Xue, Ning Xu

Non-invasive biomarkers for early diagnosis of pancreatic cancer risk: metabolite genomewide association study based on the KCPS-II cohort

Youngmin Han, Keum Ji Jung, Unchong Kim, Chan Il Jeon, Kwangbae Lee, Sun Ha Jee

Altered splicing machinery in lung carcinoids unveils NOVA1, PRPF8 and SRSF10 as novel candidates to understand tumor biology and expand biomarker discovery

Ricardo Blázquez-Encinas, Víctor García-Vioque, Teresa Caro-Cuenca, María Trinidad Moreno-Montilla, Federica Mangili, Emilia Alors-Pérez, Sebastian Ventura, Aura D. Herrera-Martínez, Paula Moreno-Casado, Marco A. Calzado, Ángel Salvatierra, María A. Gálvez-Moreno, Lynnette Fernandez-Cuesta, Matthieu Foll, Raúl M. Luque, Nicolas Alcala, Sergio Pedraza-Arevalo, Alejandro Ibáñez-Costa, Justo P. Castaño

Cucurbitacin E reduces IL-1β-induced inflammation and cartilage degeneration by inhibiting the PI3K/Akt pathway in osteoarthritic chondrocytes

Lin Wang, Hui Xu, Xin Li, Hongwei Chen, Haigang Zhang, Xunpeng Zhu, Zhijie Lin, Shilei Guo, Zhibo Bao, Haicheng Rui, Wei He, Hui Zhang