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Clinical Pharmacokinetics

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08.08.2017 | Leading Article

Key Pharmacokinetic Essentials of Fixed-Dosed Combination Products: Case Studies and Perspectives

verfasst von: Ranjeet Prasad Dash, Rana Rais, Nuggehally R. Srinivas

Erschienen in: Clinical Pharmacokinetics | Ausgabe 4/2018

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Abstract

Fixed-dose combinations are gaining popularity because they provide convenience while enhancing patient compliance. Literature examples suggest that many fixed-dose combinations are being rationalized and investigated for their potential utility in therapy. This article provides an introspection into the pharmacokinetic essentials that need to be considered prior to implementing a fixed-dose combination strategy. While the drug–drug interaction potential is an important question for the two drugs in a fixed-dose combination, the occurrence of a drug–drug interaction in itself is not a negative outcome for the proposed fixed-dose combination. However, the magnitude of a drug–drug interaction may require a re-assessment of the doses of the two drugs in a fixed-dose combination. Several case studies are provided and discussed to provide a broad perspective on the topic along with a representative framework and strategy on the development of fixed-dose combinations using key pharmacokinetic parameters.

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Titel: Key Pharmacokinetic Essentials of Fixed-Dosed Combination Products: Case Studies and Perspectives
verfasst von: Ranjeet Prasad Dash
Rana Rais
Nuggehally R. Srinivas
Publikationsdatum: 08.08.2017
Verlag: Springer International Publishing
Erschienen in: Clinical Pharmacokinetics / Ausgabe 4/2018
Print ISSN: 0312-5963
Elektronische ISSN: 1179-1926
DOI: https://doi.org/10.1007/s40262-017-0589-2

Springer Medizin

Abstract

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