Skip to main content

2019 | Spezielle Schmerztherapie | OriginalPaper | Buchkapitel

16. Komplementäre Verfahren in der Schmerztherapie

verfasst von : Bernhard Uehleke, Dominik Irnich, Wolfram Stör, Petra Bäumler, Lorenz Fischer

Erschienen in: Praktische Schmerzmedizin

Verlag: Springer Berlin Heidelberg

Zusammenfassung

Eine komplette Darstellung aller komplementärmedizinischen Verfahren unter dem Gesichtspunkt „Schmerz“ würde den Umfang dieses Buches sprengen. Es darf aber keineswegs übersehen werden, dass insbesondere bei Patienten mit chronischen Schmerzen seit Jahrzehnten großes Interesse an einer alternativen oder ergänzenden Behandlung mit anderen, vermeintlich nebenwirkungsärmeren Heilmethoden besteht. Die Inanspruchnahme von komplementärmedizinischen „Therapeuten“ und entsprechende Selbstbehandlungen wird eher selten den behandelnden Ärzten mitgeteilt. Zunächst folgt ein kurzer Überblick über den komplexen Bereich der Komplementärmedizin einschließlich einem allgemeinen Überblick über den Stand der klinischen Evidenz von komplementärmedizinischen Methoden bei Schmerz. Anschließend werden – quasi beispielhaft – drei ausgesuchte und für die Schmerztherapie besonders relevante Methoden ausführlich und für die praktische Anwendung dargestellt: Phytotherapie, Akupunktur und Neuraltherapie.
Literatur
Zurück zum Zitat Adkison JD1, Bauer DW, Chang T (2010) The effect of topical arnica on muscle pain. Ann Pharmacother 44(10):1579–1584PubMedCrossRef Adkison JD1, Bauer DW, Chang T (2010) The effect of topical arnica on muscle pain. Ann Pharmacother 44(10):1579–1584PubMedCrossRef
Zurück zum Zitat Ahluwalia J, Urban L, Bevan S, Nagy I (2003) Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid 1 receptor and the vanilloid receptor 1 in vitro. Eur J Neurosci 17:2611–2618PubMedCrossRef Ahluwalia J, Urban L, Bevan S, Nagy I (2003) Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid 1 receptor and the vanilloid receptor 1 in vitro. Eur J Neurosci 17:2611–2618PubMedCrossRef
Zurück zum Zitat Akhtar NM, Naseer R, Farooqi AZ, Aziz W, Nazir M (2004) Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee – a double-blind prospective randomized study. Clin Rheumatol 23:410–415PubMedCrossRef Akhtar NM, Naseer R, Farooqi AZ, Aziz W, Nazir M (2004) Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee – a double-blind prospective randomized study. Clin Rheumatol 23:410–415PubMedCrossRef
Zurück zum Zitat Ammon HP (2002) Boswelliasäuren (Inhaltsstoffe des Weihrauchs) als wirksame Prinzipien zur Behandlung chronisch entzündlicher Erkrankungen. Wien Med Wochenschr 152:373–378PubMedCrossRef Ammon HP (2002) Boswelliasäuren (Inhaltsstoffe des Weihrauchs) als wirksame Prinzipien zur Behandlung chronisch entzündlicher Erkrankungen. Wien Med Wochenschr 152:373–378PubMedCrossRef
Zurück zum Zitat Apati P, Szentmihalyi K, Kristo ST, Papp I, Vinkler P, Szoke E, Kery A (2003) Herbal remedies of Solidago – correlation of phytochemical characteristics and antioxidative properties. J Pharm Biomed Anal 32:1045–1053PubMedCrossRef Apati P, Szentmihalyi K, Kristo ST, Papp I, Vinkler P, Szoke E, Kery A (2003) Herbal remedies of Solidago – correlation of phytochemical characteristics and antioxidative properties. J Pharm Biomed Anal 32:1045–1053PubMedCrossRef
Zurück zum Zitat Atkinson DC, Hicks R (1975) The antiinflammatory activity of irritants. Agents Actions 5:239–249PubMedCrossRef Atkinson DC, Hicks R (1975) The antiinflammatory activity of irritants. Agents Actions 5:239–249PubMedCrossRef
Zurück zum Zitat Bäcker M, Hammes M (2005) Akupunktur in der Schmerztherapie. Urban & Fischer, München Bäcker M, Hammes M (2005) Akupunktur in der Schmerztherapie. Urban & Fischer, München
Zurück zum Zitat Backonja M, Wallace MS, Blonsky ER, Cutler BJ, Malan P Jr, Rauck R, Tobias J, NGX-4010 C116 Study Group (2008) NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomised, double-blind study. Lancet Neurol 7(12):1106–1112. Erratum in: Lancet Neurol 8(1):31 (2009)PubMedCrossRef Backonja M, Wallace MS, Blonsky ER, Cutler BJ, Malan P Jr, Rauck R, Tobias J, NGX-4010 C116 Study Group (2008) NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomised, double-blind study. Lancet Neurol 7(12):1106–1112. Erratum in: Lancet Neurol 8(1):31 (2009)PubMedCrossRef
Zurück zum Zitat Backonja MM, Malan TP, Vanhove GF, Tobias JK, C102/106 Study Group (2010) NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomized, double-blind, controlled study with an open-label extension. Pain Med 11(4):600–608PubMedCrossRef Backonja MM, Malan TP, Vanhove GF, Tobias JK, C102/106 Study Group (2010) NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomized, double-blind, controlled study with an open-label extension. Pain Med 11(4):600–608PubMedCrossRef
Zurück zum Zitat Baeumler PI, Fleckenstein J, Benedikt F, Bader J, Irnich D (2015) Acupuncture-induced changes of pressure pain threshold are mediated by segmental inhibition – a randomized controlled trial. Pain 156(11):2245–2255PubMedCrossRef Baeumler PI, Fleckenstein J, Benedikt F, Bader J, Irnich D (2015) Acupuncture-induced changes of pressure pain threshold are mediated by segmental inhibition – a randomized controlled trial. Pain 156(11):2245–2255PubMedCrossRef
Zurück zum Zitat Bahekar AA, Singh S, Saha S, Molnar J, Arora R (2007) The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: a meta-analysis. Am Heart J 154:830–837PubMedCrossRef Bahekar AA, Singh S, Saha S, Molnar J, Arora R (2007) The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: a meta-analysis. Am Heart J 154:830–837PubMedCrossRef
Zurück zum Zitat Baron R, Jänig W (1998) Schmerzsyndrome mit kausaler Beteiligung des Sympathikus. Anästhesist 74:4–23CrossRef Baron R, Jänig W (1998) Schmerzsyndrome mit kausaler Beteiligung des Sympathikus. Anästhesist 74:4–23CrossRef
Zurück zum Zitat Baron R, Schattschneider J, Binder A, Siebrecht D, Wasner G (2002) Relation between sympathetic vasoconstrictor activity and pain and hyperalgesia in complex regional pain syndromes: a case-control study. Lancet 11:1655–1660CrossRef Baron R, Schattschneider J, Binder A, Siebrecht D, Wasner G (2002) Relation between sympathetic vasoconstrictor activity and pain and hyperalgesia in complex regional pain syndromes: a case-control study. Lancet 11:1655–1660CrossRef
Zurück zum Zitat Barop H (2015) Lehrbuch und Atlas der Neuraltherapie. Haug, Stuttgart Barop H (2015) Lehrbuch und Atlas der Neuraltherapie. Haug, Stuttgart
Zurück zum Zitat Bäumler PI, Irnich D (2017) Physiologische Mechanismen der analgetischen Akupunkturwirkung – ein Updtae im klinische Kontext. DZA 60(1):9–15 Bäumler PI, Irnich D (2017) Physiologische Mechanismen der analgetischen Akupunkturwirkung – ein Updtae im klinische Kontext. DZA 60(1):9–15
Zurück zum Zitat Beijing College of Traditional Chinese Medizin et al (1980) Essentials of Chinese acupuncture. Foreign Language Press, Beijing Beijing College of Traditional Chinese Medizin et al (1980) Essentials of Chinese acupuncture. Foreign Language Press, Beijing
Zurück zum Zitat Bing Z, Cesselin F, Bourgoin S, Clot AM, Hamon M, Le Bars D (1991) Acupuncture-like stimulation induces a heterosegmental release of Met-enkephalin-like material in the rat spinal cord. Pain 47(1):71–77PubMedCrossRef Bing Z, Cesselin F, Bourgoin S, Clot AM, Hamon M, Le Bars D (1991) Acupuncture-like stimulation induces a heterosegmental release of Met-enkephalin-like material in the rat spinal cord. Pain 47(1):71–77PubMedCrossRef
Zurück zum Zitat Bissig P, Schöni-Affolter F, Fischer L, Busato A (2008) Is neural therapy cheaper than conventional medicine? A comparison of cost structure in Swiss primary care providers – an observational study. Dissertation, Universität Bern (im Druck) Bissig P, Schöni-Affolter F, Fischer L, Busato A (2008) Is neural therapy cheaper than conventional medicine? A comparison of cost structure in Swiss primary care providers – an observational study. Dissertation, Universität Bern (im Druck)
Zurück zum Zitat Bonaterra GA, Heinrich EU, Kelber O, Weiser D, Metz J, Kinscherf R (2010) Anti-inflammatory effects of the willow bark extract STW 33-I (Proaktiv(®)) in LPS-activated human monocytes and differentiated macrophages. Phytomedicine 17:1106–1113PubMedCrossRef Bonaterra GA, Heinrich EU, Kelber O, Weiser D, Metz J, Kinscherf R (2010) Anti-inflammatory effects of the willow bark extract STW 33-I (Proaktiv(®)) in LPS-activated human monocytes and differentiated macrophages. Phytomedicine 17:1106–1113PubMedCrossRef
Zurück zum Zitat Brendler T, Gruenwald J, Ulbricht C, Basch E, Natural Standard Research Collaboration (2006) Devil's Claw (Harpagophytum procumbens DC): an evidence-based systematic review by the Natural Standard Research Collaboration. J Herb Pharmacother 6(1):89–126 Brendler T, Gruenwald J, Ulbricht C, Basch E, Natural Standard Research Collaboration (2006) Devil's Claw (Harpagophytum procumbens DC): an evidence-based systematic review by the Natural Standard Research Collaboration. J Herb Pharmacother 6(1):89–126
Zurück zum Zitat Brien S, Lewith GT, McGregor G (2006) Devil’s Claw (Harpagophytum procumbens) as a treatment for osteoarthritis: a review of efficacy and safety. J Altern Complement Med 12:981–993PubMedCrossRef Brien S, Lewith GT, McGregor G (2006) Devil’s Claw (Harpagophytum procumbens) as a treatment for osteoarthritis: a review of efficacy and safety. J Altern Complement Med 12:981–993PubMedCrossRef
Zurück zum Zitat Brügger A (1980) Die Erkrankungen des Bewegungsapparates und seines Nervensystems. Fischer, Stuttgart Brügger A (1980) Die Erkrankungen des Bewegungsapparates und seines Nervensystems. Fischer, Stuttgart
Zurück zum Zitat Büttgen F (2011) Traditionelle Japanische Medizin (TJM) – geschichtlicher Abriss. DZA 54(2):10–13 Büttgen F (2011) Traditionelle Japanische Medizin (TJM) – geschichtlicher Abriss. DZA 54(2):10–13
Zurück zum Zitat Cassuto D, Sinclair R, Bonderovic M (2006) Anti-inflammatory properties of local anesthetics and their present and potential clinical implications. Acta Anaesthesiol Scand 50:265–282PubMedCrossRef Cassuto D, Sinclair R, Bonderovic M (2006) Anti-inflammatory properties of local anesthetics and their present and potential clinical implications. Acta Anaesthesiol Scand 50:265–282PubMedCrossRef
Zurück zum Zitat Chrubasik S, Conradt C (2000) Wirksamkeit eines Harpagophytum-Extrakts bei Patienten mit Rückenschmerzen. In: Rietbrock N (Hrsg) Phytopharmaka VI. Steinkopff, Darmstadt, S 94–98 Chrubasik S, Conradt C (2000) Wirksamkeit eines Harpagophytum-Extrakts bei Patienten mit Rückenschmerzen. In: Rietbrock N (Hrsg) Phytopharmaka VI. Steinkopff, Darmstadt, S 94–98
Zurück zum Zitat Chrubasik S, Eisenberg E, Balan E, Weinberger T, Luzzati R, Conradt C (2000) Treatment of low back pain exacerbation with willow bark extract: a randomised double-blind study. Am J Med 109:9–12PubMedCrossRef Chrubasik S, Eisenberg E, Balan E, Weinberger T, Luzzati R, Conradt C (2000) Treatment of low back pain exacerbation with willow bark extract: a randomised double-blind study. Am J Med 109:9–12PubMedCrossRef
Zurück zum Zitat Chrubasik S, Künzel O, Black A, Conradt C, Kerschbaumer F (2001) Potential economic impact of using a proprietary willow bark extract in outpatient treatment of low back pain: an open non-randomized study. Phytomedicine 8:241–251PubMedCrossRef Chrubasik S, Künzel O, Black A, Conradt C, Kerschbaumer F (2001) Potential economic impact of using a proprietary willow bark extract in outpatient treatment of low back pain: an open non-randomized study. Phytomedicine 8:241–251PubMedCrossRef
Zurück zum Zitat Chrubasik S, Weiser T, Beime B (2010) Effectiveness and safety of topical capsaicin cream in the treatment of chronic soft tissue pain. Phytother Res 24:1877–1885PubMedCrossRef Chrubasik S, Weiser T, Beime B (2010) Effectiveness and safety of topical capsaicin cream in the treatment of chronic soft tissue pain. Phytother Res 24:1877–1885PubMedCrossRef
Zurück zum Zitat Deal CL, Schnitzer TJ, Lipstein E, Seibold JR, Stevens RM, Levy MD, Albert D, Renold F (1991) Treatment of arthritis with topical capsaicin: a double-blind trial. Clin Ther 13:383–395PubMed Deal CL, Schnitzer TJ, Lipstein E, Seibold JR, Stevens RM, Levy MD, Albert D, Renold F (1991) Treatment of arthritis with topical capsaicin: a double-blind trial. Clin Ther 13:383–395PubMed
Zurück zum Zitat Derry S, Sven-Rice A, Cole P, Tan T, Moore RA (2013) Topical capsaicin (high concentration) for chronic neuropathic pain in adults. Cochrane Database Syst Rev 28(2):CD007393. https://doi.org/10.1002/14651858. CD007393.pub3. Review. Update in: Cochrane Database Syst Rev (1):CD007393 (2017). Derry S, Sven-Rice A, Cole P, Tan T, Moore RA (2013) Topical capsaicin (high concentration) for chronic neuropathic pain in adults. Cochrane Database Syst Rev 28(2):CD007393. https://​doi.​org/​10.​1002/​14651858. CD007393.pub3. Review. Update in: Cochrane Database Syst Rev (1):CD007393 (2017).
Zurück zum Zitat Di Lorenzo C, Dell’agli M, Badea M, Dima L, Colombo E, Sangiovanni E, Restani P, Bosisio E (2013) Plant food supplements with anti-inflammatory properties: a systematic review (II). Crit Rev Food Sci Nutr 53:507–516PubMedCrossRef Di Lorenzo C, Dell’agli M, Badea M, Dima L, Colombo E, Sangiovanni E, Restani P, Bosisio E (2013) Plant food supplements with anti-inflammatory properties: a systematic review (II). Crit Rev Food Sci Nutr 53:507–516PubMedCrossRef
Zurück zum Zitat Diener HC et al (2006) Efficacy of acupuncture for the prophylaxis of migraine: a multicentre randomised controlled clinical trial. Lancet Neurol 5(4):310–316PubMedCrossRef Diener HC et al (2006) Efficacy of acupuncture for the prophylaxis of migraine: a multicentre randomised controlled clinical trial. Lancet Neurol 5(4):310–316PubMedCrossRef
Zurück zum Zitat Egli S, Pfister M, Ludin SM, Busato A, Fischer L (2015) Long-term results of therapeutic local anesthesia (neural therapy) in 280 referred refractory chronic pain patients. BMC Complement Altern Med 15:200PubMedPubMedCentralCrossRef Egli S, Pfister M, Ludin SM, Busato A, Fischer L (2015) Long-term results of therapeutic local anesthesia (neural therapy) in 280 referred refractory chronic pain patients. BMC Complement Altern Med 15:200PubMedPubMedCentralCrossRef
Zurück zum Zitat Egorova N, Gollub RL, Kong J (2015) Repeated verum but not placebo acupuncture normalizes connectivity in brain regions dysregulated in chronic pain. Neuroimage Clin 25(9):430–435CrossRef Egorova N, Gollub RL, Kong J (2015) Repeated verum but not placebo acupuncture normalizes connectivity in brain regions dysregulated in chronic pain. Neuroimage Clin 25(9):430–435CrossRef
Zurück zum Zitat Endres HG, Victor N, Haake M, Witte S, Streitberger K, Zenz M (2007) Akupunktur bei chronischen Knie- und Rückenschmerzen Acupuncture for the Treatment of Chronic Knee and Back Pain. Dtsch Arztebl 104:A-123/B-113/C-109 Endres HG, Victor N, Haake M, Witte S, Streitberger K, Zenz M (2007) Akupunktur bei chronischen Knie- und Rückenschmerzen Acupuncture for the Treatment of Chronic Knee and Back Pain. Dtsch Arztebl 104:A-123/B-113/C-109
Zurück zum Zitat Epstein JB, Marcoe JH (1994) Topical application of capsaicin for treatment of oral neuropathic pain and trigeminal neuralgia. Oral Surg Oral Med Oral Pathol 77:135–140PubMedCrossRef Epstein JB, Marcoe JH (1994) Topical application of capsaicin for treatment of oral neuropathic pain and trigeminal neuralgia. Oral Surg Oral Med Oral Pathol 77:135–140PubMedCrossRef
Zurück zum Zitat Ernst E (1999) The efficacy of Phytodolor for the treatment of muculosceletal pain – a systematic review of randomised clinical trials. Nat Med 5:14–18 Ernst E (1999) The efficacy of Phytodolor for the treatment of muculosceletal pain – a systematic review of randomised clinical trials. Nat Med 5:14–18
Zurück zum Zitat Ernst E, Chrubasik S (2000) Phyto-anti-inflammatories. A systematic review of randomized, placebo-controlled, double-blind trials. Rheum Dis Clin N Am 26:13–27CrossRef Ernst E, Chrubasik S (2000) Phyto-anti-inflammatories. A systematic review of randomized, placebo-controlled, double-blind trials. Rheum Dis Clin N Am 26:13–27CrossRef
Zurück zum Zitat ESCOP (1996) Monographs on the medicinal uses of plant drugs. European Scientific Cooperative on Phytotherapy, Exeter ESCOP (1996) Monographs on the medicinal uses of plant drugs. European Scientific Cooperative on Phytotherapy, Exeter
Zurück zum Zitat ESCOP (1997) Monograph: Salicis cortex (Willow bark). Fascicule 4. European Scientific Cooperative on Phytotherapy, Exeter ESCOP (1997) Monograph: Salicis cortex (Willow bark). Fascicule 4. European Scientific Cooperative on Phytotherapy, Exeter
Zurück zum Zitat Etzel R (1996) Special extract of Boswellia serrata (H15) in the treatment of rheumatoid arthritis. Phytomed 3:91–94CrossRef Etzel R (1996) Special extract of Boswellia serrata (H15) in the treatment of rheumatoid arthritis. Phytomed 3:91–94CrossRef
Zurück zum Zitat Fiebich BL, Heinrich M, Hiller KO, Kammerer N (2001) Inhibition of TNFalpha synthesis in LPS-stimulated primary human monocytes by Harpagophytum extract SteiHap 69. Phytomedicine 8:28–30PubMedCrossRef Fiebich BL, Heinrich M, Hiller KO, Kammerer N (2001) Inhibition of TNFalpha synthesis in LPS-stimulated primary human monocytes by Harpagophytum extract SteiHap 69. Phytomedicine 8:28–30PubMedCrossRef
Zurück zum Zitat Fiebich BL, Muñoz E, Rose T, Weiss G, McGregor GP (2012) Molecular targets of the antiinflammatory Harpagophytum procumbens (devil’s claw): inhibition of TNFα and COX-2 gene expression by preventing activation of AP-1. Phytother Res 26:806–811PubMedCrossRef Fiebich BL, Muñoz E, Rose T, Weiss G, McGregor GP (2012) Molecular targets of the antiinflammatory Harpagophytum procumbens (devil’s claw): inhibition of TNFα and COX-2 gene expression by preventing activation of AP-1. Phytother Res 26:806–811PubMedCrossRef
Zurück zum Zitat Fischer L (2014) Neuraltherapie. Neurophysiologie, Injektionstechnik und Therapievorschläge, Vollst. überarb. 4. Aufl. Stuttgart, MVS4 Fischer L (2014) Neuraltherapie. Neurophysiologie, Injektionstechnik und Therapievorschläge, Vollst. überarb. 4. Aufl. Stuttgart, MVS4
Zurück zum Zitat Fischer L, Barop H, Marion Bergemann S (2005) Health Technology Assessment Neuraltherapie nach Huneke. PEK des Schweizerischen Bundesamtes für Gesundheit Fischer L, Barop H, Marion Bergemann S (2005) Health Technology Assessment Neuraltherapie nach Huneke. PEK des Schweizerischen Bundesamtes für Gesundheit
Zurück zum Zitat Fischer L, Ludin SM, Thommen D, Hausammann R (2010) Antrag auf Kostenübernahme durch die obligatorische Krankenpflegever-sicherung betreffend der Störfeld-Therapie (Neuraltherapie nach Huneke) an das Schweizerische Bundesamt für Gesundheit Fischer L, Ludin SM, Thommen D, Hausammann R (2010) Antrag auf Kostenübernahme durch die obligatorische Krankenpflegever-sicherung betreffend der Störfeld-Therapie (Neuraltherapie nach Huneke) an das Schweizerische Bundesamt für Gesundheit
Zurück zum Zitat Fischer L, Ludin SM, Puente de la Vega K, Sturzenegger M (2015) Neuralgia of the glossopharyngeal nerve in a patient with posttonsillectomy scarring: recovery after local infiltration of procaine – case report and pathophysiologic discussion. Case Rep Neurol Med 2015:560546 Fischer L, Ludin SM, Puente de la Vega K, Sturzenegger M (2015) Neuralgia of the glossopharyngeal nerve in a patient with posttonsillectomy scarring: recovery after local infiltration of procaine – case report and pathophysiologic discussion. Case Rep Neurol Med 2015:560546
Zurück zum Zitat Forst T, Pohlmann T, Kunt T, Goitom K, Schulz G, Lobig M, Engelbach M, Beyer J, Pfutzner A (2002) The influence of local capsaicin treatment on small nerve fibre function and neurovascular control in symptomatic diabetic neuropathy. Acta Diabetol 39:1–6PubMedCrossRef Forst T, Pohlmann T, Kunt T, Goitom K, Schulz G, Lobig M, Engelbach M, Beyer J, Pfutzner A (2002) The influence of local capsaicin treatment on small nerve fibre function and neurovascular control in symptomatic diabetic neuropathy. Acta Diabetol 39:1–6PubMedCrossRef
Zurück zum Zitat Fromy B, Abraham P, Saumet JL (1998) Non-nociceptive capsaicin-sensitive nerve terminal stimulation allows for an original vasodilatory reflex in the human skin. Brain Res 811:166–168PubMedCrossRef Fromy B, Abraham P, Saumet JL (1998) Non-nociceptive capsaicin-sensitive nerve terminal stimulation allows for an original vasodilatory reflex in the human skin. Brain Res 811:166–168PubMedCrossRef
Zurück zum Zitat Gagnier JJ, van Tulder MW, Berman B, Bombardier C (2007) Herbal medicine for low back pain: a Cochrane review. Spine (Phila Pa 1976) 32:82–92CrossRef Gagnier JJ, van Tulder MW, Berman B, Bombardier C (2007) Herbal medicine for low back pain: a Cochrane review. Spine (Phila Pa 1976) 32:82–92CrossRef
Zurück zum Zitat Galeotti N (2017) Hypericum perforatum (St John’s wort) beyond depression: a therapeutic perspective for pain conditions. J Ethnopharmacol 22(200):136–146CrossRef Galeotti N (2017) Hypericum perforatum (St John’s wort) beyond depression: a therapeutic perspective for pain conditions. J Ethnopharmacol 22(200):136–146CrossRef
Zurück zum Zitat Gleditsch J (2002) Mikroakupunktursysteme (MAPS). Hippokrates, Stuttgart Gleditsch J (2002) Mikroakupunktursysteme (MAPS). Hippokrates, Stuttgart
Zurück zum Zitat Göbel H, Schmidt G, Soyka D (1994) Effect of peppermint and eucalyptus oil preparations on neurophysiological and experimental algesimetric headache parameters. Cephalalgia 14:228–234PubMedCrossRef Göbel H, Schmidt G, Soyka D (1994) Effect of peppermint and eucalyptus oil preparations on neurophysiological and experimental algesimetric headache parameters. Cephalalgia 14:228–234PubMedCrossRef
Zurück zum Zitat Göbel H, Fresenius J, Heinze A, Dworschak M, Soyka D (1996) Effectiveness of Oleum menthae piperitae and paracetamol in therapy of headache of the tension type. Nervenarzt 67:672–681PubMedCrossRef Göbel H, Fresenius J, Heinze A, Dworschak M, Soyka D (1996) Effectiveness of Oleum menthae piperitae and paracetamol in therapy of headache of the tension type. Nervenarzt 67:672–681PubMedCrossRef
Zurück zum Zitat Göbel H, Heinze A, Ingwersen M, Niederberger U, Gerber D (2000) Wirkmechanismen von Harpagophytum-procumbens-Extrakt LI 174 bei der Behandlung von unspezifischen Rückenschmerzen. In: Rietbrock N (Hrsg) Phytopharmaka VI. Steinkopff, Darmstadt, S 99–115CrossRef Göbel H, Heinze A, Ingwersen M, Niederberger U, Gerber D (2000) Wirkmechanismen von Harpagophytum-procumbens-Extrakt LI 174 bei der Behandlung von unspezifischen Rückenschmerzen. In: Rietbrock N (Hrsg) Phytopharmaka VI. Steinkopff, Darmstadt, S 99–115CrossRef
Zurück zum Zitat Goldman N, Chen M, Fujita T, Xu Q, Peng W, Liu W, Jensen TK, Pei Y, Wang F, Han X, Chen JF, Schnermann J, Takano T, Bekar L, Tieu K, Nedergaard M (2010) Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. Nat Neurosci 13(7):883–888PubMedPubMedCentralCrossRef Goldman N, Chen M, Fujita T, Xu Q, Peng W, Liu W, Jensen TK, Pei Y, Wang F, Han X, Chen JF, Schnermann J, Takano T, Bekar L, Tieu K, Nedergaard M (2010) Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. Nat Neurosci 13(7):883–888PubMedPubMedCentralCrossRef
Zurück zum Zitat Harris RE, Zubieta JK, Scott DJ, Napadow V, Gracely RH, Clauw DJ (2009) Traditional Chinese acupuncture and placebo (sham) acupuncture are differentiated by their effects on mu-opioid receptors (MORs). NeuroImage 47(3):1077–1085PubMedCrossRef Harris RE, Zubieta JK, Scott DJ, Napadow V, Gracely RH, Clauw DJ (2009) Traditional Chinese acupuncture and placebo (sham) acupuncture are differentiated by their effects on mu-opioid receptors (MORs). NeuroImage 47(3):1077–1085PubMedCrossRef
Zurück zum Zitat Hong CH, Hur SK, Oh OJ, Kim SS, Nam KA, Lee SK (2002) Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells. J Ethnopharmacol 83:153–159PubMedCrossRef Hong CH, Hur SK, Oh OJ, Kim SS, Nam KA, Lee SK (2002) Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells. J Ethnopharmacol 83:153–159PubMedCrossRef
Zurück zum Zitat Hopfer F (1991) Phänomene bei neuraltherapeutischer Tätigkeit. Ärztez Naturheilverf 32:684–692 Hopfer F (1991) Phänomene bei neuraltherapeutischer Tätigkeit. Ärztez Naturheilverf 32:684–692
Zurück zum Zitat Hopton A, Thomas K, MacPherson H (2013) The acceptability of acupuncture for low back pain: a qualitative study of patient’s experiences nested within a randomised controlled trial. PLoS One 8(2):e56806PubMedPubMedCentralCrossRef Hopton A, Thomas K, MacPherson H (2013) The acceptability of acupuncture for low back pain: a qualitative study of patient’s experiences nested within a randomised controlled trial. PLoS One 8(2):e56806PubMedPubMedCentralCrossRef
Zurück zum Zitat Hostanska K, Melzer J, Rostock M, Suter A, Saller R (2014) Alteration of anti-inflammatory activity of Harpagophytum procumbens (devil’s claw) extract after external metabolic activation with S9 mix. J Pharm Pharmacol 66(11):1606–1614PubMedCrossRef Hostanska K, Melzer J, Rostock M, Suter A, Saller R (2014) Alteration of anti-inflammatory activity of Harpagophytum procumbens (devil’s claw) extract after external metabolic activation with S9 mix. J Pharm Pharmacol 66(11):1606–1614PubMedCrossRef
Zurück zum Zitat Houzé B, El-Khatib H, Arbour C (2017) Efficacy, tolerability, and safety of non-pharmacological therapies for chronic pain: an umbrella review on various CAM approaches. Prog Neuro-Psychopharmacol Biol Psychiatry 79(Pt B):192–205CrossRef Houzé B, El-Khatib H, Arbour C (2017) Efficacy, tolerability, and safety of non-pharmacological therapies for chronic pain: an umbrella review on various CAM approaches. Prog Neuro-Psychopharmacol Biol Psychiatry 79(Pt B):192–205CrossRef
Zurück zum Zitat Irnich D (2008) Leitfaden Triggerpunkte. Elsevier, München Irnich D (2008) Leitfaden Triggerpunkte. Elsevier, München
Zurück zum Zitat Irnich D, Beyer A (2002) Neurobiological mechanisms of acupuncture analgesia. Schmerz 16:93–102PubMedCrossRef Irnich D, Beyer A (2002) Neurobiological mechanisms of acupuncture analgesia. Schmerz 16:93–102PubMedCrossRef
Zurück zum Zitat Irving GA, Backonja MM, Dunteman E, Blonsky ER, Vanhove GF, Lu SP, Tobias J, NGX-4010 C117 Study Group (2011) A multicenter, randomized, double-blind, controlled study of NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia. Pain Med 12(1):99–109PubMedCrossRef Irving GA, Backonja MM, Dunteman E, Blonsky ER, Vanhove GF, Lu SP, Tobias J, NGX-4010 C117 Study Group (2011) A multicenter, randomized, double-blind, controlled study of NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia. Pain Med 12(1):99–109PubMedCrossRef
Zurück zum Zitat Iwasaki Y, Matsui T, Arakawa Y (2004) The protective and hormonal effects of proanthocyanidin against gastric mucosal injury in Wistar rats. J Gastroenterol 39:831–837PubMedCrossRef Iwasaki Y, Matsui T, Arakawa Y (2004) The protective and hormonal effects of proanthocyanidin against gastric mucosal injury in Wistar rats. J Gastroenterol 39:831–837PubMedCrossRef
Zurück zum Zitat Jacquet A, Girodet PO, Pariente A, Forest K, Mallet L, Moore N (2009) Phytalgic, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial. Arthritis Res Ther 11:R192PubMedPubMedCentralCrossRef Jacquet A, Girodet PO, Pariente A, Forest K, Mallet L, Moore N (2009) Phytalgic, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial. Arthritis Res Ther 11:R192PubMedPubMedCentralCrossRef
Zurück zum Zitat Jänig W (2011) Rolle von motorischen Rückkopplungsmechanismen in der Erzeugung von Schmerzen. In: Fischer L, Peuker E (Hrsg) Lehrbuch Integrative Schmerztherapie. Haug, Stuttgart, S 81–89 Jänig W (2011) Rolle von motorischen Rückkopplungsmechanismen in der Erzeugung von Schmerzen. In: Fischer L, Peuker E (Hrsg) Lehrbuch Integrative Schmerztherapie. Haug, Stuttgart, S 81–89
Zurück zum Zitat Jänig W, Baron R (2003) Complex regional pain syndrome: mistery explained? Lancet Neurol 2:687–697PubMedCrossRef Jänig W, Baron R (2003) Complex regional pain syndrome: mistery explained? Lancet Neurol 2:687–697PubMedCrossRef
Zurück zum Zitat Jänig W, Baron R (2011) Pathophysiologie des Schmerzes. In: Fischer L, Peuker E (Hrsg) Lehrbuch Integrative Schmerztherapie. Haug, Stuttgart, S 15–70 Jänig W, Baron R (2011) Pathophysiologie des Schmerzes. In: Fischer L, Peuker E (Hrsg) Lehrbuch Integrative Schmerztherapie. Haug, Stuttgart, S 15–70
Zurück zum Zitat Kennedy WR, Vanhove GF, Lu SP, Tobias J, Bley KR, Walk D, Wendelschafer-Crabb G, Simone DA, Selim MM (2010) A randomized, controlled, open-label study of the long-term effects of NGX-4010, a high-concentration capsaicin patch, on epidermal nerve fiber density and sensory function in healthy volunteers. J Pain 11(6):579–587PubMedCrossRef Kennedy WR, Vanhove GF, Lu SP, Tobias J, Bley KR, Walk D, Wendelschafer-Crabb G, Simone DA, Selim MM (2010) A randomized, controlled, open-label study of the long-term effects of NGX-4010, a high-concentration capsaicin patch, on epidermal nerve fiber density and sensory function in healthy volunteers. J Pain 11(6):579–587PubMedCrossRef
Zurück zum Zitat Kimmatkar N (2003) Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee- a randomized double blind placebo controlled trial. Phytomedicine 10:3–7PubMedCrossRef Kimmatkar N (2003) Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee- a randomized double blind placebo controlled trial. Phytomedicine 10:3–7PubMedCrossRef
Zurück zum Zitat Kizhakkeveettil A, Rose K, Kadar GE (2014) Integrative therapies for low back pain that include complementary and alternative medicine care: a systematic review. Glob Adv Health Med 3(5):49–64PubMedPubMedCentralCrossRef Kizhakkeveettil A, Rose K, Kadar GE (2014) Integrative therapies for low back pain that include complementary and alternative medicine care: a systematic review. Glob Adv Health Med 3(5):49–64PubMedPubMedCentralCrossRef
Zurück zum Zitat Klein G, Kullich W, Schnitker J, Schwann H (2006) Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs. Clin Exp Rheumatol 24:25–30PubMed Klein G, Kullich W, Schnitker J, Schwann H (2006) Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs. Clin Exp Rheumatol 24:25–30PubMed
Zurück zum Zitat Kluge G, Neugebauer G (1994) Grundlagen der Thermodynamik. Spektrum, Heidelberg Kluge G, Neugebauer G (1994) Grundlagen der Thermodynamik. Spektrum, Heidelberg
Zurück zum Zitat Kruedener S von, Schneider W, Elstner EF (1995) A combination of Populus tremula, Solidago virgaurea and Fraxinus excelsior as an anti-inflammatory and antirheumatic drug. A short review. Arzneimittelforschung 45:169– 171 Kruedener S von, Schneider W, Elstner EF (1995) A combination of Populus tremula, Solidago virgaurea and Fraxinus excelsior as an anti-inflammatory and antirheumatic drug. A short review. Arzneimittelforschung 45:169– 171
Zurück zum Zitat Langevin HM (2014) Acupuncture, connective tissue, and peripheral sensory modulation. Crit Rev Eukaryot Gene Expr 24(3):249–253PubMedCrossRef Langevin HM (2014) Acupuncture, connective tissue, and peripheral sensory modulation. Crit Rev Eukaryot Gene Expr 24(3):249–253PubMedCrossRef
Zurück zum Zitat Lee A, Chan SK, Fan LT (2015) Stimulation of the wrist acupuncture point PC6 for preventing postoperative nausea and vomiting. Cochrane Database Syst Rev 2(11):CD003281 Lee A, Chan SK, Fan LT (2015) Stimulation of the wrist acupuncture point PC6 for preventing postoperative nausea and vomiting. Cochrane Database Syst Rev 2(11):CD003281
Zurück zum Zitat Leriche R (1958) Die Chirurgie des Schmerzes. Barth, Leipzig Leriche R (1958) Die Chirurgie des Schmerzes. Barth, Leipzig
Zurück zum Zitat Lin L, Skakavac N, Lin X, Lin D, Borlongan MC, Borlongan CV, Cao C (2016) Acupuncture-induced analgesia: the role of microglial inhibition. Cell Transplant 25(4):621–628PubMedCrossRef Lin L, Skakavac N, Lin X, Lin D, Borlongan MC, Borlongan CV, Cao C (2016) Acupuncture-induced analgesia: the role of microglial inhibition. Cell Transplant 25(4):621–628PubMedCrossRef
Zurück zum Zitat Linde K, Witt CM, Streng A, Weidenhammer W, Wagenpfeil S, Brinkhaus B, Willich SN, Melchart D (2007) The impact of patient expectations on outcomes in four randomized controlled trials of acupuncture in patients with chronic pain. Pain 128(3):264–271PubMedCrossRef Linde K, Witt CM, Streng A, Weidenhammer W, Wagenpfeil S, Brinkhaus B, Willich SN, Melchart D (2007) The impact of patient expectations on outcomes in four randomized controlled trials of acupuncture in patients with chronic pain. Pain 128(3):264–271PubMedCrossRef
Zurück zum Zitat Loew D, Simmet T (2000) Zur Pharmakokinetik und zum Einfluss von Harpagophytumextrakten auf den Arachidonsäurestoffwechsel. In: Rietbrock N (Hrsg) Phytopharmaka VI. Steinkopff, Darmstadt, S 133–136CrossRef Loew D, Simmet T (2000) Zur Pharmakokinetik und zum Einfluss von Harpagophytumextrakten auf den Arachidonsäurestoffwechsel. In: Rietbrock N (Hrsg) Phytopharmaka VI. Steinkopff, Darmstadt, S 133–136CrossRef
Zurück zum Zitat Longhurst JC, Tjen-A-Looi S (2013) Acupuncture regulation of blood pressure: two decades of research. Int Rev Neurobiol 111:257–271PubMedCrossRef Longhurst JC, Tjen-A-Looi S (2013) Acupuncture regulation of blood pressure: two decades of research. Int Rev Neurobiol 111:257–271PubMedCrossRef
Zurück zum Zitat Lopez HL (2012) Nutritional interventions to prevent and treat osteoarthritis. Part I: focus on fatty acids and macronutrients. PMR 4(5 Suppl):145–154CrossRef Lopez HL (2012) Nutritional interventions to prevent and treat osteoarthritis. Part I: focus on fatty acids and macronutrients. PMR 4(5 Suppl):145–154CrossRef
Zurück zum Zitat Lyss G, Schmidt TJ, Merfort I, Pahl H (1997) Helenalin, an anti-inflammatory sesquiterpene lac-tone from Arnica, selectively inhibits transcription factor NF-kappaB. Biol Chem 378:951–962PubMedCrossRef Lyss G, Schmidt TJ, Merfort I, Pahl H (1997) Helenalin, an anti-inflammatory sesquiterpene lac-tone from Arnica, selectively inhibits transcription factor NF-kappaB. Biol Chem 378:951–962PubMedCrossRef
Zurück zum Zitat MacPherson H, Vertosick E, Lewith G, Linde K, Sherman KJ, Witt CM, Vickers AJ, Acupuncture Trialists’ Collaboration (2014) Influence of control group on effect size in trials of acupuncture for chronic pain: a secondary analysis of an individual patient data meta-analysis. PLoS One 9(4):e93739PubMedPubMedCentralCrossRef MacPherson H, Vertosick E, Lewith G, Linde K, Sherman KJ, Witt CM, Vickers AJ, Acupuncture Trialists’ Collaboration (2014) Influence of control group on effect size in trials of acupuncture for chronic pain: a secondary analysis of an individual patient data meta-analysis. PLoS One 9(4):e93739PubMedPubMedCentralCrossRef
Zurück zum Zitat Maeda Y, Kim H, Kettner N, Kim J, Cina S, Malatesta C, Gerber J, McManus C, Ong-Sutherland R, Mezzacappa P, Libby A, Mawla I, Morse LR, Kaptchuk TJ, Audette J, Napadow V (2017) Rewiring the primary somatosensory cortex in carpal tunnel syndrome with acupuncture. Brain 140:914–927PubMedPubMedCentralCrossRef Maeda Y, Kim H, Kettner N, Kim J, Cina S, Malatesta C, Gerber J, McManus C, Ong-Sutherland R, Mezzacappa P, Libby A, Mawla I, Morse LR, Kaptchuk TJ, Audette J, Napadow V (2017) Rewiring the primary somatosensory cortex in carpal tunnel syndrome with acupuncture. Brain 140:914–927PubMedPubMedCentralCrossRef
Zurück zum Zitat Maurer HR (2001) Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci 58:1234–1245PubMedCrossRef Maurer HR (2001) Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci 58:1234–1245PubMedCrossRef
Zurück zum Zitat Maurer HR (2002) Bromelain: Biochemie, Pharmakologie und medizinische Anwendung. Erfahrungsheilkunde 51:223–235CrossRef Maurer HR (2002) Bromelain: Biochemie, Pharmakologie und medizinische Anwendung. Erfahrungsheilkunde 51:223–235CrossRef
Zurück zum Zitat McCarthy GM, McCarthy DJ (1992) Treatment of topical capsaicin in the therapy of painful osteoarthritis of hands. J Rheumatol 19:604–607PubMed McCarthy GM, McCarthy DJ (1992) Treatment of topical capsaicin in the therapy of painful osteoarthritis of hands. J Rheumatol 19:604–607PubMed
Zurück zum Zitat Meißner K et al (2013) Differential effectiveness of placebo treatments: a systematic review of migraine prophylaxis. JAMA Intern Med 173(21):1941–1951PubMedCrossRef Meißner K et al (2013) Differential effectiveness of placebo treatments: a systematic review of migraine prophylaxis. JAMA Intern Med 173(21):1941–1951PubMedCrossRef
Zurück zum Zitat Melchart D, Streng A, Hoppe A, Jürgens S, Weidenhammer W, Linde K (2006) Akupunktur bei chronischen Schmerzen: Ergebnisse aus dem Modellvorhaben der Ersatzkassen Acupuncture for chronic pain – results from the research program of ten health insurance funds. Dtsch Arztebl 103:A-187/B-160/C-159 Melchart D, Streng A, Hoppe A, Jürgens S, Weidenhammer W, Linde K (2006) Akupunktur bei chronischen Schmerzen: Ergebnisse aus dem Modellvorhaben der Ersatzkassen Acupuncture for chronic pain – results from the research program of ten health insurance funds. Dtsch Arztebl 103:A-187/B-160/C-159
Zurück zum Zitat Melzak R, Wall P (1962) Pain mechanism: a new theory. Science 150:971–979CrossRef Melzak R, Wall P (1962) Pain mechanism: a new theory. Science 150:971–979CrossRef
Zurück zum Zitat Mermod J, Fischer L, Staub L, Busato A (2008) Patient satisfaction of primary care for musculoskeletal diseases: a comparison between Neural Therapy an conventional medicine. BMC Dermatol 8:33 Mermod J, Fischer L, Staub L, Busato A (2008) Patient satisfaction of primary care for musculoskeletal diseases: a comparison between Neural Therapy an conventional medicine. BMC Dermatol 8:33
Zurück zum Zitat Mueller SC, Majcher-Peszynska J, Mundkowski RG, Uehleke B, Klammt S, Sievers H, Lehnfeld R, Frank B, Thurow K, Kundt G, Drewelow B (2009) No clinically relevant CYP3A induction after St. John’s wort with low hyperforin content in healthy volunteers. Eur J Clin Pharmacol 65:81–87PubMedCrossRef Mueller SC, Majcher-Peszynska J, Mundkowski RG, Uehleke B, Klammt S, Sievers H, Lehnfeld R, Frank B, Thurow K, Kundt G, Drewelow B (2009) No clinically relevant CYP3A induction after St. John’s wort with low hyperforin content in healthy volunteers. Eur J Clin Pharmacol 65:81–87PubMedCrossRef
Zurück zum Zitat Mur E, Hartig F, Eibl G, Schirmer M (2002) Randomized double blind trial of an extract from the pentacycic alkaloid-chemotype of uncaria tomentosa for the treatment of rheumatoid arthritis. J Rheumatol 29:656–658 Mur E, Hartig F, Eibl G, Schirmer M (2002) Randomized double blind trial of an extract from the pentacycic alkaloid-chemotype of uncaria tomentosa for the treatment of rheumatoid arthritis. J Rheumatol 29:656–658
Zurück zum Zitat Murthy V, Sibbritt DW, Adams J (2015) An integrative review of complementary and alternative medicine use for back pain: a focus on prevalence, reasons for use, influential factors, self-perceived effectiveness, and communication. Spine J 15(8):1870–1883PubMedCrossRef Murthy V, Sibbritt DW, Adams J (2015) An integrative review of complementary and alternative medicine use for back pain: a focus on prevalence, reasons for use, influential factors, self-perceived effectiveness, and communication. Spine J 15(8):1870–1883PubMedCrossRef
Zurück zum Zitat Nahrstedt A, Schmidt M, Jäggi R, Metz J, Khayyal MT (2007) Willow bark extract: the contribution of polyphenols to the overall effect. Wien Med Wochenschr 157:348–351PubMedCrossRef Nahrstedt A, Schmidt M, Jäggi R, Metz J, Khayyal MT (2007) Willow bark extract: the contribution of polyphenols to the overall effect. Wien Med Wochenschr 157:348–351PubMedCrossRef
Zurück zum Zitat Obertreis B, Giller K, Teucher T, Behnke B, Schmitz H (1996) Anti-inflammatory effect of Urtica dioica folia extract in comparison to caffeic malic acid. Arzneimittelforschung 46:52–56PubMed Obertreis B, Giller K, Teucher T, Behnke B, Schmitz H (1996) Anti-inflammatory effect of Urtica dioica folia extract in comparison to caffeic malic acid. Arzneimittelforschung 46:52–56PubMed
Zurück zum Zitat Okpanyi SN, Schirpke-von Paczensky R, Dickson D (1989) Anti-inflammatory, analgesic and antipyretic effect of various plant extracts and their combinations in an animal model. Arzneimittelforschung 39:698–703PubMed Okpanyi SN, Schirpke-von Paczensky R, Dickson D (1989) Anti-inflammatory, analgesic and antipyretic effect of various plant extracts and their combinations in an animal model. Arzneimittelforschung 39:698–703PubMed
Zurück zum Zitat Oliveira MG de, Marques RB, de Santana MF, Santos AB, Brito FA, Barreto EO, De Sousa DP, Almeida FR, Badauê-Passos D Jr, Antoniolli AR, Quintans-Júnior LJ (2012) α-terpineol reduces mechanical hypernociception and inflammatory response. Basic Clin Pharmacol Toxicol 111:120–125 Oliveira MG de, Marques RB, de Santana MF, Santos AB, Brito FA, Barreto EO, De Sousa DP, Almeida FR, Badauê-Passos D Jr, Antoniolli AR, Quintans-Júnior LJ (2012) α-terpineol reduces mechanical hypernociception and inflammatory response. Basic Clin Pharmacol Toxicol 111:120–125
Zurück zum Zitat Paterson C, Britten N (2008) The patient’s experience of holistic care: insights from acupuncture research. Chronic Illn 4(4):264–277PubMedCrossRef Paterson C, Britten N (2008) The patient’s experience of holistic care: insights from acupuncture research. Chronic Illn 4(4):264–277PubMedCrossRef
Zurück zum Zitat Paterson C, Evans M, Bertschinger R, Chapman R, Norton R, Robinson J (2012) Communication about self-care in traditional acupuncture consultations: the co-construction of individualised support and advice. Patient Educ Couns 89(3):467–475PubMedCrossRef Paterson C, Evans M, Bertschinger R, Chapman R, Norton R, Robinson J (2012) Communication about self-care in traditional acupuncture consultations: the co-construction of individualised support and advice. Patient Educ Couns 89(3):467–475PubMedCrossRef
Zurück zum Zitat Pomeranz B, Stux G (2003) Scientific basis of acupuncture. Springer, BerlinCrossRef Pomeranz B, Stux G (2003) Scientific basis of acupuncture. Springer, BerlinCrossRef
Zurück zum Zitat Prigogine I, Stengers I (1981) Dialog mit der Natur. Neue Wege wissenschaftlichen Denkens. Piper, München Prigogine I, Stengers I (1981) Dialog mit der Natur. Neue Wege wissenschaftlichen Denkens. Piper, München
Zurück zum Zitat Puente de la Vega K, Gómez M, Roqueta C, Fischer L (2016) Effects on hemodynamic variables and echocardiographic parameters after stellate ganglion block in 15 healthy volunteers. Auton Neurosci 197:46–55CrossRef Puente de la Vega K, Gómez M, Roqueta C, Fischer L (2016) Effects on hemodynamic variables and echocardiographic parameters after stellate ganglion block in 15 healthy volunteers. Auton Neurosci 197:46–55CrossRef
Zurück zum Zitat Pumpa KL1, Fallon KE, Bensoussan A, Papalia S (2014) The effects of topical Arnica on performance, pain and muscle damage after intense eccentric exercise. Eur J Sport Sci 14(3):294–300PubMedCrossRef Pumpa KL1, Fallon KE, Bensoussan A, Papalia S (2014) The effects of topical Arnica on performance, pain and muscle damage after intense eccentric exercise. Eur J Sport Sci 14(3):294–300PubMedCrossRef
Zurück zum Zitat Randall C, Randall H, Dobbs F, Hutton C, Sanders H (2000) Randomized controlled trial of nettle sting for treatment of base-of-thumb pain. J R Soc Med 93:305–309PubMedPubMedCentralCrossRef Randall C, Randall H, Dobbs F, Hutton C, Sanders H (2000) Randomized controlled trial of nettle sting for treatment of base-of-thumb pain. J R Soc Med 93:305–309PubMedPubMedCentralCrossRef
Zurück zum Zitat Randall C, Dickens A, White A, Sanders H, Fox M, Campbell J (2008) Nettle sting for chronic knee pain: a randomised controlled pilot study. Complement Ther Med 16:66–72PubMedCrossRef Randall C, Dickens A, White A, Sanders H, Fox M, Campbell J (2008) Nettle sting for chronic knee pain: a randomised controlled pilot study. Complement Ther Med 16:66–72PubMedCrossRef
Zurück zum Zitat Ribbat JM, Schakau D (2001) Behandlung chronisch aktivierter Schmerzen am Bewegungsapparat. Nat Med 16:23–30 Ribbat JM, Schakau D (2001) Behandlung chronisch aktivierter Schmerzen am Bewegungsapparat. Nat Med 16:23–30
Zurück zum Zitat Riehemann K, Behnke B, Schulze-Osthoff K (1999) Plant extracts from stinging nettle (Urtica dioica), an antirheumatic remedy, inhibit the proinflammatory transcription factor NF-kappa B. FEBS Lett 442:89–94PubMedCrossRef Riehemann K, Behnke B, Schulze-Osthoff K (1999) Plant extracts from stinging nettle (Urtica dioica), an antirheumatic remedy, inhibit the proinflammatory transcription factor NF-kappa B. FEBS Lett 442:89–94PubMedCrossRef
Zurück zum Zitat Ringbom T, Segura L, Noreen Y, Perera P, Bohlin L (1998) Ursolic acid from Plantago major, a selective inhibitor of cyclooxygenase-2 catalyzed prostaglandin biosynthesis. J Nat Prod 61:1212–1215PubMedCrossRef Ringbom T, Segura L, Noreen Y, Perera P, Bohlin L (1998) Ursolic acid from Plantago major, a selective inhibitor of cyclooxygenase-2 catalyzed prostaglandin biosynthesis. J Nat Prod 61:1212–1215PubMedCrossRef
Zurück zum Zitat Rubach A (2000) Kompendium der Ohr-Akupunktur. Hippokrates, Stuttgart Rubach A (2000) Kompendium der Ohr-Akupunktur. Hippokrates, Stuttgart
Zurück zum Zitat Rubach A, Weise HJ (2000) Ohr-Akupunktur. Hippokrates, Stuttgart Rubach A, Weise HJ (2000) Ohr-Akupunktur. Hippokrates, Stuttgart
Zurück zum Zitat Safayhi H, Ammon HPT (1997) Pharmakologische Aspekte von Weihrauch und Boswelliasäuren. Pharm Ztg 142:3277–3286 Safayhi H, Ammon HPT (1997) Pharmakologische Aspekte von Weihrauch und Boswelliasäuren. Pharm Ztg 142:3277–3286
Zurück zum Zitat Safayhi H, Boden SE, Schweizer S, Ammon HP (2000) Concentration-dependent potentiating and inhibitory effects of Boswellia extracts on 5-lipoxygenase product formation in stimulated PMNL. Planta Med 66:110–113PubMedCrossRef Safayhi H, Boden SE, Schweizer S, Ammon HP (2000) Concentration-dependent potentiating and inhibitory effects of Boswellia extracts on 5-lipoxygenase product formation in stimulated PMNL. Planta Med 66:110–113PubMedCrossRef
Zurück zum Zitat Sander O, Herborn G, Rau R (1998) Is H15 (resin extract of Boswellia serrata, „incense“) a useful supplement to established drug therapy of chronic polyarthritis? Results of a double-blind pilot study. Z Rheumatol 57:11–16PubMedCrossRef Sander O, Herborn G, Rau R (1998) Is H15 (resin extract of Boswellia serrata, „incense“) a useful supplement to established drug therapy of chronic polyarthritis? Results of a double-blind pilot study. Z Rheumatol 57:11–16PubMedCrossRef
Zurück zum Zitat Schmid B (1997) Behandlung von Cox- und Gonathrosen mit einem Trockenextrakt aus Salix purpurea und S. daphnoides. Dissertation, Universität Tübingen, Pharmazie, Tübingen Schmid B (1997) Behandlung von Cox- und Gonathrosen mit einem Trockenextrakt aus Salix purpurea und S. daphnoides. Dissertation, Universität Tübingen, Pharmazie, Tübingen
Zurück zum Zitat Schmid B, Tschirdewahn B, Kötter I, Günaydin I, Lüdke R, Selbmann HK, Schaffner W, Heide L (1998) Analgesic effects of willow bark extract in osteoarthritis: results of a clinical double-blind trial. Fact 3:186CrossRef Schmid B, Tschirdewahn B, Kötter I, Günaydin I, Lüdke R, Selbmann HK, Schaffner W, Heide L (1998) Analgesic effects of willow bark extract in osteoarthritis: results of a clinical double-blind trial. Fact 3:186CrossRef
Zurück zum Zitat Schmid B, Kötter I, Heide L (2001) Pharmacokinetics of salicin after oral administration of a standardised willow bark extract. Eur J Clin Pharmacol 57:387–391PubMedCrossRef Schmid B, Kötter I, Heide L (2001) Pharmacokinetics of salicin after oral administration of a standardised willow bark extract. Eur J Clin Pharmacol 57:387–391PubMedCrossRef
Zurück zum Zitat Schmidt TJ, Brun R, Willuhn G, Khalid SA (2002) Anti-trypanosomal activity of helenalin and some structurally related sesquiterpene lactones. Planta Med 68:750–751PubMedCrossRef Schmidt TJ, Brun R, Willuhn G, Khalid SA (2002) Anti-trypanosomal activity of helenalin and some structurally related sesquiterpene lactones. Planta Med 68:750–751PubMedCrossRef
Zurück zum Zitat Schnitzer TJ, Morton C, Coker S, Flynn P (1992) Effectiveness of reduced applications of topical capsaicin (0,025 %) in osteoarthritis. Arthritis Rheum 35:1239 Schnitzer TJ, Morton C, Coker S, Flynn P (1992) Effectiveness of reduced applications of topical capsaicin (0,025 %) in osteoarthritis. Arthritis Rheum 35:1239
Zurück zum Zitat Schueler M, Messlinger K, Dux M, Neuhuber WL, De CR (2013) Extracranial projections of meningeal afferents and their impact on meningeal nociception and headache. Pain 154(9):1622–1631PubMedCrossRef Schueler M, Messlinger K, Dux M, Neuhuber WL, De CR (2013) Extracranial projections of meningeal afferents and their impact on meningeal nociception and headache. Pain 154(9):1622–1631PubMedCrossRef
Zurück zum Zitat Schweizer S, von Brocke AF, Boden SE, Bayer E, Ammon HP, Safayhi H (2000) Workup-dependent formation of 5-lipoxygenase inhibitory boswellic acid analogue. J Nat Prod 63:1058–1061PubMedCrossRef Schweizer S, von Brocke AF, Boden SE, Bayer E, Ammon HP, Safayhi H (2000) Workup-dependent formation of 5-lipoxygenase inhibitory boswellic acid analogue. J Nat Prod 63:1058–1061PubMedCrossRef
Zurück zum Zitat Speranski AD (1950) Grundlage einer Theorie der Medizin (ins Deutsche übertragen von Roques KR). Sänger, Berlin Speranski AD (1950) Grundlage einer Theorie der Medizin (ins Deutsche übertragen von Roques KR). Sänger, Berlin
Zurück zum Zitat Stander S, Luger TA (2003) Antipruritic effects of pimecrolimus and tacrolimus. Hautarzt 54:413–417PubMedCrossRef Stander S, Luger TA (2003) Antipruritic effects of pimecrolimus and tacrolimus. Hautarzt 54:413–417PubMedCrossRef
Zurück zum Zitat Stör W (2006) Abrechnung und Qualitätsmanagement in der Akupunktur. Elsevier, Urban & Fischer, München/Jena Stör W (2006) Abrechnung und Qualitätsmanagement in der Akupunktur. Elsevier, Urban & Fischer, München/Jena
Zurück zum Zitat Stör W, Hermkes A, Hammes M, Huemer G, Steveling A (2001) Grundkurs 1. In: Stör W (Hrsg) Akupunkturausbildung. Deutsche Ärztegesellschaft für Akupunktur, München Stör W, Hermkes A, Hammes M, Huemer G, Steveling A (2001) Grundkurs 1. In: Stör W (Hrsg) Akupunkturausbildung. Deutsche Ärztegesellschaft für Akupunktur, München
Zurück zum Zitat Sun Y, Gan TJ, Dubose JW, Habib AS (2008) Acupuncture and related techniques for postoperative pain: a systematic review of randomized controlled trials. Br J Anaesth 101(2):151–160PubMedCrossRef Sun Y, Gan TJ, Dubose JW, Habib AS (2008) Acupuncture and related techniques for postoperative pain: a systematic review of randomized controlled trials. Br J Anaesth 101(2):151–160PubMedCrossRef
Zurück zum Zitat Thomas DA, Maslin B, Legler A, Springer E, Asgerally A, Vadivelu N (2016) Role of alternative therapies for chronic pain syndromes. Curr Pain Headache Rep 20(5):29PubMedCrossRef Thomas DA, Maslin B, Legler A, Springer E, Asgerally A, Vadivelu N (2016) Role of alternative therapies for chronic pain syndromes. Curr Pain Headache Rep 20(5):29PubMedCrossRef
Zurück zum Zitat Tobaldini G, Aisengart B, Lima MM, Tambeli CH, Fischer L (2014) Ascending nociceptive control contributes to the antinociceptive effect of acupuncture in a rat model of acute pain. J Pain 15(4):422–434PubMedCrossRef Tobaldini G, Aisengart B, Lima MM, Tambeli CH, Fischer L (2014) Ascending nociceptive control contributes to the antinociceptive effect of acupuncture in a rat model of acute pain. J Pain 15(4):422–434PubMedCrossRef
Zurück zum Zitat Travell JG, Simons DG (1982) Myofascial pain and dysfunction, Bd I und II. Williams & Wilkins, Baltimore Travell JG, Simons DG (1982) Myofascial pain and dysfunction, Bd I und II. Williams & Wilkins, Baltimore
Zurück zum Zitat Turo D, Otto P, Hossain M, Gebreab T, Armstrong K, Rosenberger WF, Shao H, Shah JP, Gerber LH, Sikdar S (2015) Novel use of ultrasound elastography to quantify muscle tissue changes after dry needling of myofascial trigger points in patients with chronic myofascial pain. J Ultrasound Med 34:2149–2161PubMedPubMedCentralCrossRef Turo D, Otto P, Hossain M, Gebreab T, Armstrong K, Rosenberger WF, Shao H, Shah JP, Gerber LH, Sikdar S (2015) Novel use of ultrasound elastography to quantify muscle tissue changes after dry needling of myofascial trigger points in patients with chronic myofascial pain. J Ultrasound Med 34:2149–2161PubMedPubMedCentralCrossRef
Zurück zum Zitat Uehleke B (1996) Phytobalneologie. Z Phytother 17:26–43 Uehleke B (1996) Phytobalneologie. Z Phytother 17:26–43
Zurück zum Zitat Uehleke B, Stange R (2009) A clinical surrogate model for proof of efficacy of external phytomedicines for muscle pain. Results of a randomized, placebo-controlled clinical study in volunteers with muscle pain due to physical training. Phytomedicine 16:509–512PubMedCrossRef Uehleke B, Stange R (2009) A clinical surrogate model for proof of efficacy of external phytomedicines for muscle pain. Results of a randomized, placebo-controlled clinical study in volunteers with muscle pain due to physical training. Phytomedicine 16:509–512PubMedCrossRef
Zurück zum Zitat Uehleke B, Wöhling H (2004) Wirksamkeit und Verträglichkeit des Heusacks im Rahmen der Kneipp-Kur. Phys Med Rehab Kuror 14:97–101CrossRef Uehleke B, Wöhling H (2004) Wirksamkeit und Verträglichkeit des Heusacks im Rahmen der Kneipp-Kur. Phys Med Rehab Kuror 14:97–101CrossRef
Zurück zum Zitat Uehleke B, Brignoli R, Rostock M, Saller R, Melzer J (2011) Phytodolor® in musculoskeletal disorders: re-analysis and meta-analysis. Forsch Komplementmed 18:249–256PubMedCrossRef Uehleke B, Brignoli R, Rostock M, Saller R, Melzer J (2011) Phytodolor® in musculoskeletal disorders: re-analysis and meta-analysis. Forsch Komplementmed 18:249–256PubMedCrossRef
Zurück zum Zitat Uehleke B, Müller J, Stange R, Kelber O, Melzer J (2013) Willow bark extract STW 33-I in the long term treatment of outpatients with rheumatic pain mainly osteoarthritis or back pain. Phytomedicine, 20(11):980–984PubMedCrossRef Uehleke B, Müller J, Stange R, Kelber O, Melzer J (2013) Willow bark extract STW 33-I in the long term treatment of outpatients with rheumatic pain mainly osteoarthritis or back pain. Phytomedicine, 20(11):980–984PubMedCrossRef
Zurück zum Zitat Unschuld PU (1997) Chinesische Medizin. C.H. Beck, München Unschuld PU (1997) Chinesische Medizin. C.H. Beck, München
Zurück zum Zitat Valentao P, Fernandes E, Carvalho F, Andrade PB, Seabra RM, Bastos ML (2003) Hydroxyl radical and hypochlorous acid scavenging activity of small centaury (Centaurium erythraea) infusion. A comparative study with green tea (Camellia sinensis). Phytomedicine 10:517–522PubMedCrossRef Valentao P, Fernandes E, Carvalho F, Andrade PB, Seabra RM, Bastos ML (2003) Hydroxyl radical and hypochlorous acid scavenging activity of small centaury (Centaurium erythraea) infusion. A comparative study with green tea (Camellia sinensis). Phytomedicine 10:517–522PubMedCrossRef
Zurück zum Zitat Villar-Garea A, Fraga MF, Espada J, Esteller M (2003) Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. Cancer Res 63:4984–4989PubMed Villar-Garea A, Fraga MF, Espada J, Esteller M (2003) Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. Cancer Res 63:4984–4989PubMed
Zurück zum Zitat Vishal AA, Mishra A, Raychaudhuri SP (2011) A double blind, randomized, placebo controlled clinical study evaluates the early efficacy of aflapin in subjects with osteoarthritis of knee. Int J Med Sci 8:615–622PubMedPubMedCentralCrossRef Vishal AA, Mishra A, Raychaudhuri SP (2011) A double blind, randomized, placebo controlled clinical study evaluates the early efficacy of aflapin in subjects with osteoarthritis of knee. Int J Med Sci 8:615–622PubMedPubMedCentralCrossRef
Zurück zum Zitat Vlachojannis JE, Cameron M, Chrubasik S (2009) A systematic review on the effectiveness of willow bark for musculoskeletal pain. Phytother Res 23:897–900PubMedCrossRef Vlachojannis JE, Cameron M, Chrubasik S (2009) A systematic review on the effectiveness of willow bark for musculoskeletal pain. Phytother Res 23:897–900PubMedCrossRef
Zurück zum Zitat Wagner H, Fessler B, Knaus U, Wierer M (1987) Zum Wirknachweis antiphlogistisch wirksamer Arzneidrogen. Z Phytother 8:135–140 Wagner H, Fessler B, Knaus U, Wierer M (1987) Zum Wirknachweis antiphlogistisch wirksamer Arzneidrogen. Z Phytother 8:135–140
Zurück zum Zitat Watson CP, Tyler KL, Bickers DR, Millikan LE, Smith S, Coleman E (1993) A randomized vehicle-controlled trial of topical capsaicin in the treatment of postherpetic neuralgia. Clin Ther 15:510–526PubMed Watson CP, Tyler KL, Bickers DR, Millikan LE, Smith S, Coleman E (1993) A randomized vehicle-controlled trial of topical capsaicin in the treatment of postherpetic neuralgia. Clin Ther 15:510–526PubMed
Zurück zum Zitat Webster LR, Malan TP, Tuchman MM, Mollen MD, Tobias JK, Vanhove GF (2010) A multicenter, randomized, double-blind, controlled dose finding study of NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia. J Pain 11(10):972–982PubMedCrossRef Webster LR, Malan TP, Tuchman MM, Mollen MD, Tobias JK, Vanhove GF (2010) A multicenter, randomized, double-blind, controlled dose finding study of NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia. J Pain 11(10):972–982PubMedCrossRef
Zurück zum Zitat Widrig R, Suter A, Saller R, Melzer J (2007) Choosing between NSAID and arnica for topical treatment of hand osteoarthritis in a randomised, double-blind study. Rheumatol Int 27:585–591PubMedCrossRef Widrig R, Suter A, Saller R, Melzer J (2007) Choosing between NSAID and arnica for topical treatment of hand osteoarthritis in a randomised, double-blind study. Rheumatol Int 27:585–591PubMedCrossRef
Zurück zum Zitat Witt CM, Brinkhaus B, Jena S, Selim D, Straub C, Willich SN (2006) Wirksamkeit, Sicherheit und Wirtschaftlichkeit der Akupunktur – Ein Modellvorhaben mit der Techniker Krankenkasse. Dtsch Arztebl 103:A-196/B-169/C-167 Witt CM, Brinkhaus B, Jena S, Selim D, Straub C, Willich SN (2006) Wirksamkeit, Sicherheit und Wirtschaftlichkeit der Akupunktur – Ein Modellvorhaben mit der Techniker Krankenkasse. Dtsch Arztebl 103:A-196/B-169/C-167
Zurück zum Zitat Witt CM, Martins F, Willich SN, Schützler L (2012) Can I help you? Physicians’ expectations as predictor for treatment outcome. Eur J Pain 16:1455–1466PubMedCrossRef Witt CM, Martins F, Willich SN, Schützler L (2012) Can I help you? Physicians’ expectations as predictor for treatment outcome. Eur J Pain 16:1455–1466PubMedCrossRef
Zurück zum Zitat Zhang R, Lao L, Ren K, Berman BM (2014) Mechanisms of acupuncture-electroacupuncture on persistent pain. Anesthesiology 120(2):482–503PubMedCrossRef Zhang R, Lao L, Ren K, Berman BM (2014) Mechanisms of acupuncture-electroacupuncture on persistent pain. Anesthesiology 120(2):482–503PubMedCrossRef
Zurück zum Zitat Zhao ZQ (2008) Neural mechanism underlying acupuncture analgesia. Prog Neurobiol 85(4):355–375PubMedCrossRef Zhao ZQ (2008) Neural mechanism underlying acupuncture analgesia. Prog Neurobiol 85(4):355–375PubMedCrossRef
Zurück zum Zitat Zielisch H (2010) Phytotherapie bei Rückenschmerzen: zwei Anwendungsbeobachtungen zur Evaluation der Wirksamkeit und Verträglichkeit von Weidenrinde und Johanniskraut bei Patienten mit chronisch unspezifischen Rückenschmerzen und depressiver Verstimmung. Med. Dissertation, Berlin Zielisch H (2010) Phytotherapie bei Rückenschmerzen: zwei Anwendungsbeobachtungen zur Evaluation der Wirksamkeit und Verträglichkeit von Weidenrinde und Johanniskraut bei Patienten mit chronisch unspezifischen Rückenschmerzen und depressiver Verstimmung. Med. Dissertation, Berlin
Zurück zum Zitat Zypen E van der (1967) Elektronenmikroskopische Befunde an der Endausbreitung des vegetativen Nervensystems und ihre Deutung. Acta Anatom 67:431–515 Zypen E van der (1967) Elektronenmikroskopische Befunde an der Endausbreitung des vegetativen Nervensystems und ihre Deutung. Acta Anatom 67:431–515
Metadaten
Titel
Komplementäre Verfahren in der Schmerztherapie
verfasst von
Bernhard Uehleke
Dominik Irnich
Wolfram Stör
Petra Bäumler
Lorenz Fischer
Copyright-Jahr
2019
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-662-57487-4_16

Update AINS

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.