Background
Methods
Selection criteria
Data extraction
Statistical analysis
-
wtmt vs wtwt (OR1)
-
mtmt vs wtwt (OR2).
-
Recessive model (mtmt versus wt carriers): if OR2 ≠ 1 and OR1 = 1
-
Dominant model (mt carriers versus wtwt): if OR2 = OR1 ≠ 1,
Results
Characteristics of the studies
Rs number | First author | Year | Tumour site | Country | Ethnicity | Sample size (No. cases/controls) | Crude OR° (95 % CI) recessive model | Crude OR (95 % CI) dominant model |
---|---|---|---|---|---|---|---|---|
rs762551 | Goodman MT. [73] | 2001 | Ovaries | USA | Mixed | 116/138*a | 0.52 (0.19–1.43) | – |
Sachse C. [18] | 2002 | Colorectum | UK | Caucasian | 490/593*ª | 1.15 (0.70–1.88) | – | |
Goodman MT. [74] | 2003 | Ovaries | USA | Mixed | 164/194*ª | 0.73 (0.34–1.55) | – | |
Hopper J. [36] | 2003 | Breast | Australia | Caucasian | 204/287*c | 0.55 (0.27–1.13) | – | |
Doherty JA. [68] | 2005 | Endometrium | USA | Mixed | 371/420*ª | 1.27 (0.75–2.15) | – | |
Landi S. [16] | 2005 | Colorectum | Spain | Caucasian | 361/321*b |
1.74 (1.05–2.88)
| – | |
Le Marchand L. [39] | 2005 | Breast | USA | Mixed | 1339/1369*a |
0.73 (0.55–0.96)
| – | |
Prawan A. [81] | 2005 | Liver | Thailand | Asian | 216/233*a | 0.52 (0.24–1.13) | – | |
Mochizuki J. [79] | 2005 | Liver | Japan | Asian | 31/123*a | 1.35 (0.26–7.01) | – | |
Agudo A. [61] | 2006 | Stomach | European countries1 | Caucasian | 242/943*a | 0.88 (0.50–1.55) | – | |
Bae SY. [9] | 2006 | Colorectum | S. Korea | Asian | 111/93*b | 1.14 (0.51–2.54) | – | |
De Roos AJ. [67] | 2006 | Lymphoma | USA | Mixed | 745/640*a | 0.91 (0.63–1.31) | – | |
Li D. [8] | 2006 | Pancreas | USA | Mixed | 307/333*b | 1.10 (0.65–1.84) | – | |
Long JR. [41] | 2006 | Breast | China | Asian | 1082/1139*a | 0.89 (0.71–1.13) | – | |
Rebbeck TR [82] | 2006 | Endometrium | USA | Mixed | 475/1233*a | 1.03 (0.73–1.46) | – | |
Kiss I. [13] | 2007 | Colorectum | Hungary | Caucasian | 500/500*b | 1.07 (0.74–1.54) | – | |
Kury S. [15] | 2007 | Colorectum | France | Caucasian | 1013/1118*a | 1.03 (0.75–1.41) | – | |
Osawa Y. [29] | 2007 | Lung | Japan | Asian | 103/111*a | 1.17 (0.57–2.42) | – | |
Takata Y. [46] | 2007 | Breast | USA (Hawaii) | Mixed | 325/250*a | 0.76 (0.39–1.49) | – | |
Yoshida K. [23] | 2007 | Colorectum | Japan | Asian | 64/111*a | 0.57 (0.21–1.53) | – | |
Gemignani F. [26] | 2007 | Lung | European countries2 | Caucasian | 297/310*b | 0.86 (0.50–1.49) | – | |
Kotsopoulos J. [38] | 2007 | Breast | Canada | Caucasian | 170/241*b |
2.12 (0.99–4.57)
| – | |
Gulyaeva LF. [35] | 2008 | Endometrium | Russia | Caucasian | 166/180*a | 2.20 (0.40–12.16) | – | |
Gulyaeva LF. [35] | 2008 | Ovaries | Russia | Caucasian | 96/180*a |
9.21 (1.95–43.53)
| – | |
Gulyaeva LF. [35] | 2008 | Breast | Russia | Caucasian | 93/180*a |
27.58 (6.32–120.35)
| – | |
Hirata H. [75] | 2008 | Endometrium | USA | Caucasian | 150/165*a | 0.96 (0.62–1.51) | – | |
Saebo M. [19] | 2008 | Colorectum | Norway | Caucasian | 198/222*a | 1.05 (0.49–2.23) | – | |
Suzuki H. [84] | 2008 | Pancreas | USA | Caucasian | 649/585*a | 0.93 (0.56–1.54) | – | |
Figueroa JD [48] | 2008 | Bladder | Spain | Caucasian | 1101/1021*b | 0.80 (0.62–1.04) | – | |
Zienolddiny S. [32] | 2008 | Lung | Norway | Caucasian | 335/393*a | 1.43 (0.88–2.32) | – | |
Cotterchio M. [11] | 2008 | Colorectum | Canada | Caucasian | 835/1247*a | 0.91 (0.67–1.23) | – | |
Aldrich MC. [7] | 2009 | Lung | USA | Mixed | 113/299*a |
3.36 (1.58–7.13)
| – | |
Altayli E. [4] | 2009 | Bladder | Turkey | Caucasian | 135/128*b | 1.51 (0.88–2.60) | – | |
B’chir F. [24] | 2009 | Lung | Tunisia | Caucasian | 101/98*b | 0.90 (0.47–1.70) | – | |
Kobayashi M. [78] | 2009 | Stomach | Japan | Asian | 141/286*b | 0.62 (0.33–1.18) | – | |
Kobayashi M. [14] | 2009 | Colorectum | Japan | Asian | 104/225*b | 0.64 (0.31–1.32) | – | |
Shimada N (a) [45] | 2009 | Breast | Japan and Brazil | Asian | 483/484*b | 1.02 (0.71–1.47) | – | |
Shimada N (b) [45] | 2009 | Breast | Brazil | Mixed | 389/389*b |
0.50 (0.31–0.80)
| – | |
Sangrajrang S. [44] | 2009 | Breast | Thailand | Asian | 552/483*b |
2.72 (1.52–4.86)
| – | |
Villanueva C. [52] | 2009 | Bladder | Spain | Caucasian | 1034/911*b | 0.82 (0.62–1.07) | – | |
Canova C. [64] | 2009 | UADT | European countries3 | Caucasian | 1480/1437*b | 0.88 (0.69–1.13) | – | |
Cleary SP [10] | 2010 | Colorectum | Canada | Caucasian | 1165/1290*a | 0.93 (0.71–1.22) | – | |
Pavanello S. [50] | 2010 | Bladder | Italy | Caucasian | 155/161*b | 0.57 (0.25–1.30) | – | |
Singh A. [31] | 2010 | Lung | India | Caucasian | 200/200*a |
0.61 (0.37–1.00)
| – | |
The MARIE-GENICA Consortium [43] | 2010 | Breast | Germany | Caucasian | 3147/5485*a | 1.04 (0.88–1.22) | – | |
Canova C. [65] | 2010 | UADT | Italy | Caucasian | 376/386*b | 1.21 (0.77–1.89) | – | |
Ashton KA [62] | 2010 | Endometrium | Australia | Caucasian | 191/291*a | 1.03 (0.71–1.49) | – | |
Guey LT [49] | 2010 | Bladder | Spain | Caucasian | 1005/1021*b |
0.77 (0.58–1.00)
| – | |
Rudolph A. [17] | 2011 | Colorectum | Germany | Caucasian | 678/680*a | 1.38 (0.93–2.05) | – | |
Sainz J. [20] | 2011 | Colorectum | Germany | Caucasian | 1764/1786*a | 0.95 (0.75–1.19) | – | |
Jang JH [77] | 2012 | Pancreas | Canada | Mixed | 447/880*a | 1.08 (0.73–1.59) | – | |
Khvostova EP [37] | 2012 | Breast | Russia | Caucasian | 323/526*b |
1.82 (1.14–2.90)
| – | |
Pavanello S. [30] | 2012 | Lung | Denmark | Caucasian | 421/776*a |
1.63 (1.08–2.48)
| – | |
Wang J. [21] | 2012 | Colorectum | USA | Mixed | 305/357*a | 0.97 (0.55–1.70) | – | |
Anderson LN [33] | 2012 | Breast | Canada | Mixed | 886/932*a |
1.50 (1.09–2.07)
| – | |
Ayari I. [34] | 2013 | Breast | Tunisia | Caucasian | 117/42*b | 1.62 (0.51–5.11) | – | |
Barbieri RB [63] | 2013 | Thyroid gland | Brasil | Mixed | 123/339*a |
2.12 (1.16–3.87)
| – | |
Dik VK [12] | 2013 | Colorectum | The Netherlands | Caucasian | 970/1590*a | 1.10 (0.85–1.43) | – | |
Gervasini G. [27] | 2013 | Lung | Spain | Caucasian | 95/196*b | 1.25 (0.60–2.61) | – | |
Lee HJ. [40] | 2013 | Breast | USA | Mixed | 579/981*a | 1.22 (0.85–1.75) | – | |
Lowcock E. [42] | 2013 | Breast | Canada | Mixed | 1693/1761*a | 1.24 (0.97–1.57) | – | |
Ghoshal U. [72] | 2014 | Stomach | India | Caucasian | 88/170*a | 1.13 (0.57–2.22) | – | |
Mikhalenko AP. [28] | 2014 | Lung | Belarus | Caucasian | 92/328*a | 1.14 (0.44–2.93) | – | |
Shahabi A. [83] | 2014 | Prostate | USA | Mixed | 1480/777*a | 0.97 (0.72–1.30) | – | |
rs2069514 | Sachse C. [18] | 2002 | Colorectum | UK | Caucasian | 60/73*a | – |
12.71 (1.56–103.44)
|
Tsukino H. [51] | 2004 | Bladder | Japan | Asian | 306/306*a | – | 0.95 (0.69–1.31) | |
Landi S. [16] | 2005 | Colorectum | Spain | Caucasian | 328/295*b | – | 0.90 (0.38–2.10) | |
Chiou HL [25] | 2005 | Lung | China | Asian | 162/208*b | – | 1.04 (0.69–1.57) | |
Agudo A. [61] | 2006 | Stomach | European countries1 | Caucasian | 243/945*a | – | 1.66 (0.72–3.84) | |
Chen X. [66] | 2006 | Liver | China | Asian | 430/546*a | – | 0.97 (0.75–1.24) | |
Bae SY. [9] | 2006 | Colorectum | S. Korea | Asian | 111/93*b | – | 0.68 (0.39–1.18) | |
Yoshida K. [23] | 2007 | Colorectum | Japan | Asian | 66/113*a | – | 0.82 (0.44–1.52) | |
Osawa Y. [29] | 2007 | Lung | Japan | Asian | 106/113*a | – | 0.80 (0.46–1.36) | |
Gemignani F. [26] | 2007 | Lung | European countries2 | Caucasian | 278/294*b | – | 0.52 (0.16–1.75) | |
Zienolddiny S. [32] | 2008 | Lung | Norway | Caucasian | 243/214*a | – | 0.65 (0.22–1.91) | |
Imaizumi T. [76] | 2009 | Liver | Japan | Asian | 209/256*a | – | 0.88 (0.61–1.27) | |
B’chir F. [24] | 2009 | Lung | Tunisia | Caucasian | 101/98*b | – |
5.88 (2.96–11.70)
| |
Yeh CC [22] | 2009 | Colorectum | Taiwan | Asian | 718/731*b | – | 1.08 (0.88–1.32) | |
Gemignani F. [71] | 2009 | Pleura | Italy | Caucasian | 92/643*b | – | 0.33 (0.04–2.45) | |
Singh A. [31] | 2010 | Lung | India | Caucasian | 200/200*a | – | 0.84 (0.47–1.50) | |
Pavanello S. [30] | 2012 | Lung | Denmark | Caucasian | 423/777*a | – | 0.85 (0.32–2.24) | |
Ayari I. [34] | 2013 | Breast | Tunisia | Caucasian | 109/41*b | – |
0.35 (0.14–0.90)
| |
Gervasini G. [27] | 2013 | Lung | Spain | Caucasian | 95/196*b | – | 2.67 (0.70–10.17) | |
Cui X. [47] | 2013 | Bladder | Japan | Asian | 282/257*b | – | 0.89 (0.63–1.26) | |
rs2069526 | Sachse C. [18] | 2002 | Colorectum | UK | Caucasian | 490/593*a | – | 0.86 (0.60–1.22) |
Landi S. [16] | 2005 | Colorectum | Spain | Caucasian | 321/288*b | – | 1.27 (0.55–2.90) | |
Gemignani F. [26] | 2007 | Lung | European countries2 | Caucasian | 247/251*b | – |
0.34 (0.14–0.81)
| |
Zienolddiny S. [32] | 2008 | Lung | Norway | Caucasian | 194/239*a | – | 1.66 (0.37–7.49) | |
Gemignani F. [71] | 2009 | Pleura | Italy | Caucasian | 78/579*b | – | 1.10 (0.42–2.90) | |
Singh A. [31] | 2010 | Lung | India | Caucasian | 200/200*a | – | 1.07 (0.65–1.75) | |
Gervasini G. [27] | 2013 | Lung | Spain | Caucasian | 95/196*b | – | 1.36 (0.57–3.27) | |
rs2470890 | Hopper J. [36] | 2003 | Breast | Australia | Caucasian | 204/287*c | 0.82 (0.47–1.43) | – |
Landi S. [16] | 2005 | Colorectum | Spain | Caucasian | 353/320*b | 1.24 (0.84–1.82) | – | |
Chen X. [66] | 2006 | Liver | China | Asian | 428/545*a | 0.53 (0.27–1.06) | – | |
Kury S. [15] | 2007 | Colorectum | France | Caucasian | 1013/1118*a | 1.07 (0.90–1.27) | – | |
Gemignani F. [26] | 2007 | Lung | European countries2 | Caucasian | 283/298*b | 0.83 (0.51–1.35) | – | |
Aldrich MC. [7] | 2009 | Lung | USA | Mixed | 113/299*a | 1.12 (0.59–2.13) | – | |
Gemignani F. [71] | 2009 | Pleura | Italy | Caucasian | 85/669*b | 1.02 (0.56–1.88) | – | |
Canova C. [64] | 2009 | UADT | European countries3 | Caucasian | 1455/1403*b | 1.03 (0.84–1.26) | – | |
Canova C. [65] | 2010 | UADT | Italy | Caucasian | 374/387*b |
1.51 (1.02–2.23)
| – | |
Anderson LN [33] | 2012 | Breast | Canada | Mixed | 884/927*a |
1.49 (1.18–1.89)
| – | |
Eom SY. [69] | 2013 | Stomach | S. Korea | Asian | 473/472*b | 1.15 (0.55–2.37) | – | |
rs2472304 | Hopper J. [36] | 2003 | Breast | Australia | Caucasian | 204/286*c | 0.81 (0.46–1.43) | – |
Sangrajrang S. [44] | 2009 | Breast | Thailand | Asian | 552/478*b | 1.16 (0.59–2.29) | – | |
Aldrich MC. [7] | 2009 | Lung | USA | Mixed | 112/297*a | 1.12 (0.59–2.14) | – | |
Ferlin A. [70] | 2010 | Testicles | Italy | Caucasian | 234/218*a |
0.68 (0.46–1.01)
| – | |
rs35694136 | Li D. [8] | 2006 | Pancreas | USA | Mixed | 307/329*b | – | 0.87 (0.63–1.18) |
Olivieri EH [80] | 2009 | Head and Neck | Brasil | Mixed | 81/134*b | – |
8.98 (4.49–17.93)
| |
Pavanello S. [50] | 2010 | Bladder | Italy | Caucasian | 167/141*b | – | 0.73 (0.46–1.14) | |
Singh A. [31] | 2010 | Lung | India | Caucasian | 200/200*a | – |
1.65 (1.11–2.45)
| |
Pavanello S. [30] | 2012 | Lung | Denmark | Caucasian | 415/760*a | – | 0.98 (0.65–1.49) | |
Ayari I. [34] | 2013 | Breast | Tunisia | Caucasian | 108/38*b | – | 0.88 (0.40–1.93) |
Quantitative synthesis
Number cases/controls | Recessive model | |||||
---|---|---|---|---|---|---|
Exposed | Not exposed | OR° | 95 % CI° | I
2
(%) | P value for heterogeneity | |
rs762551 | 3373/4006 | 29,808/36,562 | 1.03 | 0.96–1.12 | 50.4 | <0.01 |
Study design | ||||||
Hospital based | 1048/1110 | 8289/8482 | 1.03 | 0.88–1.20 | 60.3 | <0.01 |
Population based | 2314/2869 | 21,326/27,820 | 1.05 | 0.96–1.15 | 41.8 | <0.01 |
Study sample size | ||||||
Large | 2883/3387 | 27,381/32,680 | 1.02 | 0.94–1.11 | 55.9 | <0.01 |
Small | 490/619 | 2427/3882 | 1.09 | 0.90–1.32 | 36.0 | 0.05 |
Ethnicity | ||||||
Asian | 348/414 | 2539/2874 | 0.95 | 0.72–1.27 | 54.6 | 0.02 |
Caucasian | 2132/2600 | 18,305/23,388 | 1.03 | 0.94–1.13 | 42.4 | <0.01 |
Mixed | 893/992 | 8964/10,300 | 1.05 | 0.89–1.25 | 62.8 | <0.01 |
Tumour site | ||||||
Bladder | 392/436 | 3038/2806 |
0.84
|
0.70–1.01
| 28.5 | 0.23 |
Breast | 1097/1280 | 10,285/13,269 | 1.17 | 0.94–1.45 | 79.2 | <0.01 |
Colorectum | 803/934 | 7755/9199 | 1.03 | 0.93–1.14 | 0.0 | 0.56 |
Endometrium | 258/391 | 1095/1898 | 1.06 | 0.87–1.30 | 0.0 | 0.85 |
Liver | 12/26 | 235/330 | 0.63 | 0.30–1.32 | 5.0 | 0.31 |
Lung | 221/265 | 1536/2446 | 1.20 | 0.87–1.64 | 58.9 | 0.01 |
Ovaries | 27/34 | 349/478 | 1.31 | 0.33–5.19 | 80.3 | 0.01 |
Pancreas | 107/142 | 1296/1656 | 1.04 | 0.80–1.36 | 0.0 | 0.87 |
Stomach | 46/141 | 425/1258 | 0.85 | 0.59–1.21 | 0.0 | 0.45 |
UADT | 186/192 | 1670/1631 | 0.97 | 0.73–1.29 | 29.9 | 0.23 |
Number cases/controls | Dominant model | |||||
Exposed | Not exposed | OR | 95 % CI | I
2
(%) | P value for heterogeneity | |
rs2069514 | 1229/1373 | 3333/5026 | 0.99 | 0.81–1.21 | 60.0 | <0.01 |
Study design | ||||||
Hospital based | 758/783 | 1727/2329 | 1.01 | 0.73–1.40 | 73.7 | <0.01 |
Population based | 471/590 | 1606/2697 | 0.94 | 0.78–1.14 | 10.6 | 0.35 |
Study sample size | ||||||
Large | 969/1085 | 2691/3736 | 0.97 | 0.86–1.09 | 0.0 | 0.89 |
Small | 260/288 | 642/1290 | 1.18 | 0.65–2.11 | 81.1 | <0.01 |
Ethnicity | ||||||
Asian | 1093/1235 | 1297/1388 | 0.96 | 0.86–1.07 | 0.0 | 0.86 |
Caucasian | 136/138 | 2036/3638 | 1.16 | 0.63–2.14 | 75.7 | <0.01 |
Tumour site | ||||||
Bladder | 236/237 | 352/326 | 0.92 | 0.73–1.17 | 0.0 | 0.81 |
Colorectum | 447/458 | 836/847 | 0.96 | 0.65–1.43 | 53.2 | 0.07 |
Liver | 315/409 | 324/393 | 0.94 | 0.76–1.15 | 0.0 | 0.68 |
Lung | 211/219 | 1397/1881 | 1.16 | 0.68–1.99 | 76.3 | <0.01 |
Number cases/controls | Dominant model | |||||
Exposed | Not exposed | OR | 95 % CI | I
2
(%) | P value for heterogeneity | |
rs2069526 | 139/202 | 1486/2144 | 0.94 | 0.70–1.26 | 20.7 | 0.27 |
Study design | ||||||
Hospital based | 35/78 | 706/1236 | 0.89 | 0.47–1.72 | 53.9 | 0.09 |
Population based | 104/124 | 780/908 | 0.94 | 0.71–1.25 | 0.0 | 0.59 |
Study sample size | ||||||
Large | 121/151 | 1137/1181 | 0.85 | 0.56–1.28 | 49.4 | 0.12 |
Small | 18/51 | 349/963 | 1.29 | 0.71–2.35 | 0.0 | 0.89 |
Ethnicity | ||||||
Caucasian | 139/202 | 1486/2144 | 0.94 | 0.70–1.26 | 20.7 | 0.27 |
Tumour site | ||||||
Colorectum | 74/93 | 737/788 | 0.91 | 0.66–1.26 | 0.0 | 0.40 |
Lung | 60/75 | 676/811 | 0.90 | 0.47–1.71 | 55.4 | 0.08 |
Number cases/controls | Recessive model | |||||
Exposed | Not exposed | OR | 95 % CI | I
2
(%) | P value for heterogeneity | |
rs2470890 | 1106/1187 | 4559/5538 | 1.11 | 0.96–1.28 | 39.0 | 0.09 |
Study design | ||||||
Hospital based | 429/480 | 2594/3069 | 1.10 | 0.95–1.27 | 0.0 | 0.46 |
Population based | 655/670 | 1783/2219 | 1.09 | 0.80–1.50 | 70.5 | 0.02 |
Study sample size | ||||||
Large | 1077/1043 | 4390/4714 | 1.11 | 0.94–1.30 | 50.9 | 0.04 |
Small | 29/144 | 169/824 | 1.07 | 0.69–1.66 | 0.0 | 0.85 |
Ethnicity | ||||||
Asian | 28/42 | 873/975 | 0.77 | 0.37–1.64 | 55.4 | 0.13 |
Caucasian | 863/957 | 2904/3525 | 1.07 | 0.96–1.20 | 0.0 | 0.47 |
Mixed | 215/188 | 782/1038 |
1.44
|
1.16–1.80
| 0.0 | 0.41 |
Tumour site | ||||||
Breast | 222/189 | 866/1025 | 1.17 | 0.65–2.08 | 73.4 | 0.05 |
Colorectum | 500/509 | 866/929 | 1.10 | 0.94–1.28 | 0.0 | 0.51 |
Lung | 48/77 | 348/520 | 0.92 | 0.63–1.37 | 0.0 | 0.47 |
UADT | 294/262 | 1535/1528 | 1.20 | 0.83–1.74 | 65.7 | 0.09 |
Number cases/controls | Recessive model | |||||
Exposed | Not exposed | OR | 95 % CI | I
2
(%) | P value for heterogeneity | |
rs2472304 | 127/172 | 975/1107 | 0.84 | 0.64–1.09 | 0.0 | 0.43 |
Study design | ||||||
Population based | 85/120 | 261/395 | 0.82 | 0.51–1.30 | 40.4 | 0.20 |
Study sample size | ||||||
Large | 112/136 | 878/846 | 0.79 | 0.59–1.05 | 0.0 | 0.41 |
Ethnicity | ||||||
Caucasian | 92/121 | 346/383 |
0.72
|
0.52–0.99
| 0.0 | 0.61 |
Tumour site | ||||||
Breast | 42/52 | 714/712 | 0.94 | 0.61–1.45 | 0.0 | 0.43 |
Number cases/controls | Dominant model | |||||
Exposed | Not exposed | OR | 95 % CI | I
2
(%) | P value for heterogeneity | |
rs35694136 | 439/419 | 839/1183 | 1.37 | 0.78–2.42 | 89.0 | <0.01 |
Study design | ||||||
Hospital based | 290/263 | 373/379 | 1.46 | 0.56–3.77 | 92.7 | <0.01 |
Population based | 149/156 | 466/804 | 1.28 | 0.77–2.13 | 68.4 | 0.08 |
Study sample size | ||||||
Large | 290/319 | 632/970 | 1.11 | 0.75–1.64 | 69.8 | 0.04 |
Small | 149/100 | 207/213 | 1.78 | 0.37–8.60 | 94.6 | <0.01 |
Ethnicity | ||||||
Caucasian | 255/241 | 635/898 | 1.04 | 0.70–1.53 | 62.0 | 0.05 |
Mixed | 184/178 | 204/285 | 2.73 | 0.28–27.09 | 97.3 | <0.01 |
Tumour site | ||||||
Lung | 149/156 | 466/804 | 1.28 | 0.77–2.13 | 68.4 | 0.08 |