BMC Cancer

A systematic review of geographical variation in access to chemotherapy

• Open Access
• Research article

Charlotte Chamberlain, Amanda Owen-Smith, Jenny Donovan, William Hollingworth

All-trans retinoic acid synergizes with topotecan to suppress AML cells via promoting RARα-mediated DNA damage

• Open Access
• Research article

Zhifei Xu, JinJin Shao, Lin Li, Xueming Peng, Min Chen, Guanqun Li, Hao Yan, Bo Yang, Peihua Luo, Qiaojun He

MicroRNA expression analysis in high fat diet-induced NAFLD-NASH-HCC progression: study on C57BL/6J mice

• Open Access
• Research article

Alessandra Tessitore, Germana Cicciarelli, Filippo Del Vecchio, Agata Gaggiano, Daniela Verzella, Mariafausta Fischietti, Valentina Mastroiaco, Antonella Vetuschi, Roberta Sferra, Remo Barnabei, Daria Capece, Francesca Zazzeroni, Edoardo Alesse

Prevalence and correlates of healthy lifestyle behaviors among early cancer survivors

• Open Access
• Research article

Iris M. Kanera, Catherine A. W. Bolman, Ilse Mesters, Roy A. Willems, Audrey A. J. M. Beaulen, Lilian Lechner

Population attributable risks of modifiable reproductive factors for breast and ovarian cancers in Korea

• Open Access
• Research article

Boyoung Park, Sohee Park, Hai-Rim Shin, Aesun Shin, Yohwan Yeo, Ji-Yeob Choi, Kyu-Won Jung, Byoung-Gie Kim, Yong-Man Kim, Dong-Young Noh, Sei-Hyun Ahn, Jae Weon Kim, Sokbom Kang, Jae Hoon Kim, Tae Jin Kim, Daehee Kang, Keun-Young Yoo, Sue K. Park

Successful en bloc venous resection with reconstruction and subsequent radiotherapy for 2 consecutive recurrences of intravenous leiomyoma—a case report

• Open Access
• Case report

Ying Zhang, Leslie H. Clark, Xiugui Sheng, Chunxiao Zhou

The role of GAGE cancer/testis antigen in metastasis: the jury is still out

• Open Access
• Research article

Morten Frier Gjerstorff, Mikkel Green Terp, Malene Bredahl Hansen, Henrik Jørn Ditzel

Erratum to: KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin in prostate cancer models

• Open Access
• Erratum

Giovanni Luca Gravina, Andrea Mancini, Patrizia Sanita, Flora Vitale, Francesco Marampon, Luca Ventura, Yosef Landesman, Dilara McCauley, Michael Kauffman, Sharon Shacham, Claudio Festuccia

Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma

• Open Access
• Research article

Yves-Paul Vandewynckel, Debby Laukens, Lindsey Devisscher, Eliene Bogaerts, Annelies Paridaens, Anja Van den Bussche, Sarah Raevens, Xavier Verhelst, Christophe Van Steenkiste, Bart Jonckx, Louis Libbrecht, Anja Geerts, Peter Carmeliet, Hans Van Vlierberghe

18F-fluoride positron emission tomography/computed tomography and bone scintigraphy for diagnosis of bone metastases in newly diagnosed, high-risk prostate cancer patients: study protocol for a multicentre, diagnostic test accuracy study

• Open Access
• Study protocol

Randi F. Fonager, Helle D. Zacho, Niels C. Langkilde, Lars J. Petersen

RASSF1 tumor suppressor gene in pancreatic ductal adenocarcinoma: correlation of expression, chromosomal status and epigenetic changes

• Open Access
• Research article

Eliana Amato, Stefano Barbi, Matteo Fassan, Claudio Luchini, Caterina Vicentini, Matteo Brunelli, Giuseppe Malleo, Aldo Scarpa, Giorgio Malpeli

Lgr5 expression is a valuable prognostic factor for colorectal cancer: evidence from a meta-analysis

• Open Access
• Research article

Yangyan Jiang, Wenlu Li, Xin He, Hongbo Zhang, Fangzhen Jiang, Zhigang Chen

GENESIS: a French national resource to study the missing heritability of breast cancer

• Open Access
• Research article

Olga M. Sinilnikova, Marie-Gabrielle Dondon, Séverine Eon-Marchais, Francesca Damiola, Laure Barjhoux, Morgane Marcou, Carole Verny-Pierre, Valérie Sornin, Lucie Toulemonde, Juana Beauvallet, Dorothée Le Gal, Noura Mebirouk, Muriel Belotti, Olivier Caron, Marion Gauthier-Villars, Isabelle Coupier, Bruno Buecher, Alain Lortholary, Catherine Dugast, Paul Gesta, Jean-Pierre Fricker, Catherine Noguès, Laurence Faivre, Elisabeth Luporsi, Pascaline Berthet, Capucine Delnatte, Valérie Bonadona, Christine M. Maugard, Pascal Pujol, Christine Lasset, Michel Longy, Yves-Jean Bignon, Claude Adenis, Laurence Venat-Bouvet, Liliane Demange, Hélène Dreyfus, Marc Frenay, Laurence Gladieff, Isabelle Mortemousque, Séverine Audebert-Bellanger, Florent Soubrier, Sophie Giraud, Sophie Lejeune-Dumoulin, Annie Chevrier, Jean-Marc Limacher, Jean Chiesa, Anne Fajac, Anne Floquet, François Eisinger, Julie Tinat, Chrystelle Colas, Sandra Fert-Ferrer, Clotilde Penet, Thierry Frebourg, Marie-Agnès Collonge-Rame, Emmanuelle Barouk-Simonet, Valérie Layet, Dominique Leroux, Odile Cohen-Haguenauer, Fabienne Prieur, Emmanuelle Mouret-Fourme, François Cornélis, Philippe Jonveaux, Odile Bera, Eve Cavaciuti, Anne Tardivon, Fabienne Lesueur, Sylvie Mazoyer, Dominique Stoppa-Lyonnet, Nadine Andrieu

Novel polymorphisms in caspase-8 are associated with breast cancer risk in the California Teachers Study

• Open Access
• Research article

Hannah Lui Park, Argyrios Ziogas, Jenny Chang, Bhumi Desai, Leona Bessonova, Chad Garner, Eunjung Lee, Susan L. Neuhausen, Sophia S. Wang, Huiyan Ma, Jessica Clague, Peggy Reynolds, James V. Lacey Jr, Leslie Bernstein, Hoda Anton-Culver

CD133+ liver cancer stem cells resist interferon-gamma-induced autophagy

• Open Access
• Research article

Jian Li, Jin-Na Chen, Ting-Ting Zeng, Fan He, Shu-Peng Chen, Stephanie Ma, Jiong Bi, Xiao-Feng Zhu, Xin-Yuan Guan

Prognostic value of high FoxC2 expression in resectable non-small cell lung cancer, alone or in combination with E-cadherin expression

• Open Access
• Research article

Wei Jiang, Hong Fan, Cheng Qian, Jianyong Ding, Qun Wang, Xuguang Pang

Silvestrol induces early autophagy and apoptosis in human melanoma cells

• Open Access
• Research article

Wei-Lun Chen, Li Pan, A. Douglas Kinghorn, Steven M. Swanson, Joanna E. Burdette

The lack of clinical value of peritoneal washing cytology in high risk patients undergoing risk-reducing salpingo-oophorectomy: a retrospective study and review

• Open Access
• Research article

F. Blok, E. M. Roes, G. J. L. H. van Leenders, H. J. van Beekhuizen

Cetuximab plus platinum-based chemotherapy in head and neck squamous cell carcinoma: a randomized, double-blind safety study comparing cetuximab produced from two manufacturing processes using the EXTREME study regimen

• Open Access
• Research article

Denis Soulières, Jose Luis Aguilar, Eric Chen, Krzysztof Misiukiewicz, Scott Ernst, Hyun Jung Lee, Katherine Bryant, Shuang He, Coleman K. Obasaju, Shao-Chun Chang, Steve Chin, Douglas Adkins

Prognostic value of protein inhibitor of activated STAT3 in breast cancer patients receiving hormone therapy

• Open Access
• Research article

Sheau-Fang Yang, Ming-Feng Hou, Fang-Ming Chen, Fu Ou-Yang, Yang-Chang Wu, Chee-Yin Chai, Yao-Tsung Yeh

DocOx (AIO-PK0106): a phase II trial of docetaxel and oxaliplatin as a second line systemic therapy in patients with advanced pancreatic ductal adenocarcinoma

• Open Access
• Research article

Thomas J. Ettrich, Lukas Perkhofer, Goetz von Wichert, Thomas M. Gress, Patrick Michl, Holger F. Hebart, Petra Büchner-Steudel, Michael Geissler, Rainer Muche, Bettina Danner, Volker Kächele, Andreas W. Berger, Melanie Güthle, Thomas Seufferlein

Correlation of KIT and PDGFRA mutational status with clinical benefit in patients with gastrointestinal stromal tumor treated with sunitinib in a worldwide treatment-use trial

• Open Access
• Research article

Peter Reichardt, George D. Demetri, Hans Gelderblom, Piotr Rutkowski, Seock-Ah Im, Sudeep Gupta, Yoon-Koo Kang, Patrick Schöffski, Jochen Schuette, Denis Soulières, Jean-Yves Blay, David Goldstein, Kolette Fly, Xin Huang, Massimo Corsaro, Maria Jose Lechuga, Jean-Francois Martini, Michael C. Heinrich

A potent betulinic acid analogue ascertains an antagonistic mechanism between autophagy and proteasomal degradation pathway in HT-29 cells

• Open Access
• Research article

Debasmita Dutta, Biswajit Chakraborty, Ankita Sarkar, Chinmay Chowdhury, Padma Das

FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine

• Open Access
• Research article

Dannel Yeo, Hong He, Oneel Patel, Andrew M. Lowy, Graham S. Baldwin, Mehrdad Nikfarjam

Dronabinol has preferential antileukemic activity in acute lymphoblastic and myeloid leukemia with lymphoid differentiation patterns

• Open Access
• Research article

Kerstin Maria Kampa-Schittenhelm, Olaf Salitzky, Figen Akmut, Barbara Illing, Lothar Kanz, Helmut Rainer Salih, Marcus Matthias Schittenhelm

Novel c-Met inhibitor suppresses the growth of c-Met-addicted gastric cancer cells

• Open Access
• Research article

Chi Hoon Park, Sung Yun Cho, Jae Du Ha, Heejung Jung, Hyung Rae Kim, Chong Ock Lee, In-Young Jang, Chong Hak Chae, Heung Kyoung Lee, Sang Un Choi

Erratum to: RIZ1: a potential tumor suppressor in glioma

• Open Access
• Erratum

Chenran Zhang, Qiubei Zhu, Hua He, Lei Jiang, Qiang Qiang, Liuhua Hu, Guohan Hu, Ying Jiang, Xuehua Ding, Yicheng Lu

Genetic heterogeneity of actionable genes between primary and metastatic tumor in lung adenocarcinoma

• Open Access
• Research article

Eun Young Kim, Eun Na Cho, Heae Surng Park, Arum Kim, Ji Young Hong, Seri Lim, Jong Pil Youn, Seung Yong Hwang, Yoon Soo Chang

Mutations in TP53 increase the risk of SOX2 copy number alterations and silencing of TP53 reduces SOX2 expression in non-small cell lung cancer

• Open Access
• Research article

Johanna Samulin Erdem, Vidar Skaug, Per Bakke, Amund Gulsvik, Aage Haugen, Shanbeh Zienolddiny

Correlation analyses between pre- and post-operative adverse events in gastric cancer patients receiving preoperative treatment and gastrectomy

• Open Access
• Research article

Shuang-Xi Li, Sang Hyuk Seo, Yoon Young Choi, Masatoshi Nakagawa, Ji Yeong An, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Sung Hoon Noh

Trabectedin for inoperable or recurrent soft tissue sarcoma in adult patients: a retrospective cohort study

• Open Access
• Research article

Fernando A. Angarita, Amanda J. Cannell, Albiruni R. Abdul Razak, Brendan C. Dickson, Martin E. Blackstein

(Secondary) solid tumors in thyroid cancer patients treated with the multi-kinase inhibitor sorafenib may present diagnostic challenges

• Open Access
• Case report

Tatiana C. Schneider, Ellen Kapiteijn, Tom van Wezel, Jan W. A. Smit, Jacobus J. M. van der Hoeven, Hans Morreau

Regulatory dissection of the CBX5 and hnRNPA1 bi-directional promoter in human breast cancer cells reveals novel transcript variants differentially associated with HP1α down-regulation in metastatic cells

• Open Access
• Research article

Johan Vad-Nielsen, Kristine Raaby Jakobsen, Tina Fuglsang Daugaard, Rune Thomsen, Anja Brügmann, Boe Sandahl Sørensen, Anders Lade Nielsen

MIR494 reduces renal cancer cell survival coinciding with increased lipid droplets and mitochondrial changes

• Open Access
• Research article

Punashi Dutta, Edward Haller, Arielle Sharp, Meera Nanjundan

Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines

• Open Access
• Research article

Haatisha Jandu, Kristina Aluzaite, Louise Fogh, Sebastian Wingaard Thrane, Julie B. Noer, Joanna Proszek, Khoa Nguyen Do, Stine Ninel Hansen, Britt Damsgaard, Signe Lykke Nielsen, Magnus Stougaard, Birgitta R. Knudsen, José Moreira, Petra Hamerlik, Madhavsai Gajjar, Marcel Smid, John Martens, John Foekens, Yves Pommier, Nils Brünner, Anne-Sofie Schrohl, Jan Stenvang

Clinicopathological analysis in patients with neuroendocrine tumors that metastasized to the brain

• Open Access
• Research article

Jiro Akimoto, Hirokazu Fukuhara, Tomohiro Suda, Kenta Nagai, Megumi Ichikawa, Shinjiro Fukami, Michihiro Kohno, Jun Matsubayashi, Toshitaka Nagao

Molecular targeted photoimmunotherapy for HER2-positive human gastric cancer in combination with chemotherapy results in improved treatment outcomes through different cytotoxic mechanisms

• Open Access
• Research article

Kimihiro Ito, Makoto Mitsunaga, Seiji Arihiro, Masayuki Saruta, Mika Matsuoka, Hisataka Kobayashi, Hisao Tajiri

LINE-1 silencing by retinoblastoma proteins is effected through the nucleosomal and remodeling deacetylase multiprotein complex

• Open Access
• Research article

Diego E. Montoya-Durango, Kenneth A. Ramos, Pasano Bojang, Lorell Ruiz, Irma N. Ramos, Kenneth S. Ramos

Aspirin inhibits epithelial-to-mesenchymal transition and migration of oncogenic K-ras-expressing non-small cell lung carcinoma cells by down-regulating E-cadherin repressor Slug

• Open Access
• Research article

Poulami Khan, Argha Manna, Shilpi Saha, Suchismita Mohanty, Shravanti Mukherjee, Minakshi Mazumdar, Deblina Guha, Tanya Das

Gene methylation profile of gastric cancerous tissue according to tumor site in the stomach

• Open Access
• Research article

Rita Kupcinskaite-Noreikiene, Rasa Ugenskiene, Alius Noreika, Viktoras Rudzianskas, Jurgita Gedminaite, Jurgita Skieceviciene, Elona Juozaityte

Pre-treatment neutrophil to lymphocyte ratio predicts the chemoradiotherapy outcome and survival in patients with oral squamous cell carcinoma: a retrospective study

• Open Access
• Research article

Hikaru Nakashima, Yuichiro Matsuoka, Ryoji Yoshida, Masashi Nagata, Akiyuki Hirosue, Kenta Kawahara, Junki Sakata, Hidetaka Arita, Akimitsu Hiraki, Hideki Nakayama

Asian expert recommendation on management of skin and mucosal effects of radiation, with or without the addition of cetuximab or chemotherapy, in treatment of head and neck squamous cell carcinoma

• Open Access
• Correspondence

Guopei Zhu, Jin-Ching Lin, Sung-Bae Kim, Jacques Bernier, Jai Prakash Agarwal, Jan B. Vermorken, Dang Huy Quoc Thinh, Hoi-Ching Cheng, Hwan Jung Yun, Imjai Chitapanarux, Prasert Lertsanguansinchai, Vijay Anand Reddy, Xia He

Thrombocytosis and hyperfibrinogenemia are predictive factors of clinical outcomes in high-grade serous ovarian cancer patients

• Open Access
• Research article

Zheng Feng, Hao Wen, Rui Bi, Yachen Duan, Wentao Yang, Xiaohua Wu

Impact of the introduction of EBUS on time to management decision, complications, and invasive modalities used to diagnose and stage lung cancer: a pragmatic pre-post study

• Open Access
• Research article

Neli S. Slavova-Azmanova, Catalina Lizama, Claire E. Johnson, Herbert P. Ludewick, Leanne Lester, Shanka Karunarathne, Martin Phillips

Both Talin-1 and Talin-2 correlate with malignancy potential of the human hepatocellular carcinoma MHCC-97 L cell

• Open Access
• Research article

Kun-peng Fang, Wei Dai, Yan-Hong Ren, Ye-Chuan Xu, She-min Zhang, Ye-Ben Qian

Long-term use of lenalidomide and low-dose dexamethasone in Chinese patients with relapsed/refractory multiple myeloma: MM-024 Extended Access Program

• Open Access
• Research article

Xin Du, Jie Jin, Zhen Cai, Fangping Chen, Dao-bin Zhou, Li Yu, Xiaoyan Ke, Xiao Li, Depei Wu, Fanyi Meng, Dena DeMarco, Jingshan Zhang, Jay Mei, Jian Hou

Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer

• Open Access
• Research article

Ryan A. Denu, Lauren M. Zasadil, Craig Kanugh, Jennifer Laffin, Beth A. Weaver, Mark E. Burkard

Cancer survival in New South Wales, Australia: socioeconomic disparities remain despite overall improvements

• Open Access
• Research article

Julia F. Stanbury, Peter D. Baade, Yan Yu, Xue Qin Yu

The dual specificity phosphatase 2 gene is hypermethylated in human cancer and regulated by epigenetic mechanisms

• Open Access
• Research article

Tanja Haag, Antje M. Richter, Martin B. Schneider, Adriana P. Jiménez, Reinhard H. Dammann

US-localized diffuse optical tomography in breast cancer: comparison with pharmacokinetic parameters of DCE-MRI and with pathologic biomarkers

• Open Access
• Research article

Min Jung Kim, Min-Ying Su, Hon J Yu, Jeon-Hor Chen, Eun-Kyung Kim, Hee Jung Moon, Ji Soo Choi

Low oxygen tension reverses antineoplastic effect of iron chelator deferasirox in human glioblastoma cells

• Open Access
• Research article

Claire Legendre, Sylvie Avril, Catherine Guillet, Emmanuel Garcion

Associations of microbiota and toll-like receptor signaling pathway in esophageal adenocarcinoma

• Open Access
• Research article

Ali H. Zaidi, Lori A. Kelly, Rachael E. Kreft, Mark Barlek, Ashten N. Omstead, Daisuke Matsui, Natalie H. Boyd, Kathryn E. Gazarik, Megan I. Heit, Laura Nistico, Pashtoon M. Kasi, Tracy L. Spirk, Barbara Byers, Emily J. Lloyd, Rodney J. Landreneau, Blair A. Jobe

Cooperation of Sox4 with β-catenin/p300 complex in transcriptional regulation of the Slug gene during divergent sarcomatous differentiation in uterine carcinosarcoma

• Open Access
• Research article

Hisako Inoue, Hiroyuki Takahashi, Miki Hashimura, Koji Eshima, Masashi Akiya, Toshihide Matsumoto, Makoto Saegusa

Establishment and characterization of a metastasis model of human gastric cancer in nude mice

• Open Access
• Research article

Kesheng Li, Huifen Du, Xiaowen Lian, Dandan Chai, Xinwen Li, Rong Yang, Chunya Wang

Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility

• Open Access
• Research article

Hui-min Zhou, Yuan-yuan Fang, Paul M. Weinberger, Ling-ling Ding, John K. Cowell, Farlyn Z. Hudson, Mingqiang Ren, Jeffrey R. Lee, Qi-kui Chen, Hong Su, William S. Dynan, Ying Lin

Fusion with stem cell makes the hepatocellular carcinoma cells similar to liver tumor-initiating cells

• Open Access
• Research article

Ran Wang, Shuxun Chen, Changxian Li, Kevin Tak Pan Ng, Chi-wing Kong, Jinping Cheng, Shuk Han Cheng, Ronald A. Li, Chung Mau Lo, Kwan Man, Dong Sun

Cancer risk in East Asian patients associated with acquired haemolytic anaemia: a nationwide population-based cohort study

• Open Access
• Research article

Victor C. Kok, Fung-Chang Sung, Chia-Hung Kao, Che-Chen Lin, Chun-Hung Tseng

Dietary leucine supplementation minimises tumour-induced damage in placental tissues of pregnant, tumour-bearing rats

• Open Access
• Research article

Bread Leandro Gomes Cruz, Priscila Cristina da Silva, Rebeka Tomasin, Andre Gustavo Oliveira, Lais Rosa Viana, Emilianne Miguel Salomao, Maria Cristina Cintra Gomes-Marcondes

Metabolic syndrome diagnosis and widespread high grade prostatic intraepithelial neoplasia significantly increase prostate cancer risk: results from a multicenter biopsy study

• Open Access
• Research article

Antonio Cicione, Cosimo De Nunzio, Andrea Tubaro, Francesco Cantiello, Stefano Manno, Carlos Oliveira, Estevao Lima, Rocco Damiano

Differences in TGF-β1 signaling and clinicopathologic characteristics of histologic subtypes of gastric cancer

• Open Access
• Research article

Kyung Ho Pak, Dong Hoon Kim, Hyunki Kim, Do Hyung Lee, Jae-Ho Cheong

Feasibility outcomes of a presurgical randomized controlled trial exploring the impact of caloric restriction and increased physical activity versus a wait-list control on tumor characteristics and circulating biomarkers in men electing prostatectomy for prostate cancer

• Open Access
• Research article

Wendy Demark-Wahnefried, Jeffery W. Nix, Gary R. Hunter, Soroush Rais-Bahrami, Renee A. Desmond, Balu Chacko, Casey D. Morrow, Maria Azrad, Andrew D. Frugé, Yuko Tsuruta, Travis Ptacek, Scott A. Tully, Roanne Segal, William E. Grizzle

Metastatic EML4-ALK fusion detected by circulating DNA genotyping in an EGFR-mutated NSCLC patient and successful management by adding ALK inhibitors: a case report

• Open Access
• Case report

Wenhua Liang, Qihua He, Ying Chen, Shaokun Chuai, Weiqiang Yin, Wei Wang, Guilin Peng, Caicun Zhou, Jianxing He

High mannose-binding Pseudomonas fluorescens lectin (PFL) downregulates cell surface integrin/EGFR and induces autophagy in gastric cancer cells

• Open Access
• Research article

Yuichiro Sato, Takanori Kubo, Kinjiro Morimoto, Kazuyoshi Yanagihara, Toshio Seyama

Novel germline mutations and unclassified variants of BRCA1 and BRCA2 genes in Chinese women with familial breast/ovarian cancer

• Open Access
• Research article

Wen-Ming Cao, Yun Gao, Hong-Jian Yang, Shang-Nao Xie, Xiao-Wen Ding, Zhi-Wen Pan, Wei-Wu Ye, Xiao-Jia Wang

Pitfalls of practicing cancer epidemiology in resource-limited settings: the case of survival and loss to follow-up after a diagnosis of Kaposi’s sarcoma in five countries across sub-Saharan Africa

• Open Access
• Research article

Esther Freeman, Aggrey Semeere, Megan Wenger, Mwebesa Bwana, F. Chite Asirwa, Naftali Busakhala, Emmanuel Oga, Elima Jedy-Agba, Vivian Kwaghe, Kenneth Iregbu, Antoine Jaquet, Francois Dabis, Habakkuk Azinyui Yumo, Jean Claude Dusingize, David Bangsberg, Kathryn Anastos, Sam Phiri, Julia Bohlius, Matthias Egger, Constantin Yiannoutsos, Kara Wools-Kaloustian, Jeffrey Martin

Scenario drafting for early technology assessment of next generation sequencing in clinical oncology

• Open Access
• Research article

S.E.P. Joosten, V.P. Retèl, V.M.H. Coupé, M.M. van den Heuvel, W.H. van Harten

FDG PET/CT as a prognostic biomarker in the era of molecular-targeting therapies: max SUVmax predicts survival of patients with advanced renal cell carcinoma

• Open Access
• Research article

Noboru Nakaigawa, Keiichi Kondo, Ukihide Tateishi, Ryogo Minamimoto, Tomohiro Kaneta, Kazuhiro Namura, Daiki Ueno, Kazuki Kobayashi, Takeshi Kishida, Ichiro Ikeda, Hisashi Hasumi, Kazuhide Makiyama, Yoshinobu Kubota, Tomio Inoue, Masahiro Yao

Optimal regimen of trastuzumab in combination with oxaliplatin/ capecitabine in first-line treatment of HER2-positive advanced gastric cancer (CGOG1001): a multicenter, phase II trial

• Open Access
• Research article

Jifang Gong, Tianshu Liu, Qingxia Fan, Li Bai, Feng Bi, Shukui Qin, Jinwan Wang, Nong Xu, Ying Cheng, Yuxian Bai, Wei Liu, Liwei Wang, Lin Shen

A randomized phase 3 study on the optimization of the combination of bevacizumab with FOLFOX/OXXEL in the treatment of patients with metastatic colorectal cancer-OBELICS (Optimization of BEvacizumab scheduLIng within Chemotherapy Scheme)

• Open Access
• Study protocol

Antonio Avallone, Maria Carmela Piccirillo, Luigi Aloj, Guglielmo Nasti, Paolo Delrio, Francesco Izzo, Elena Di Gennaro, Fabiana Tatangelo, Vincenza Granata, Ernesta Cavalcanti, Piera Maiolino, Francesco Bianco, Pasquale Aprea, Mario De Bellis, Biagio Pecori, Gerardo Rosati, Chiara Carlomagno, Alessandro Bertolini, Ciro Gallo, Carmela Romano, Alessandra Leone, Corradina Caracò, Elisabetta de Lutio di Castelguidone, Gennaro Daniele, Orlando Catalano, Gerardo Botti, Antonella Petrillo, Giovanni M. Romano, Vincenzo R. Iaffaioli, Secondo Lastoria, Francesco Perrone, Alfredo Budillon

The MYCN-HMGA2-CDKN2A pathway in non-small cell lung carcinoma—differences in histological subtypes

• Open Access
• Research article

Hanne A. Eide, Ann Rita Halvorsen, Maria Moksnes Bjaanæs, Hossein Piri, Ruth Holm, Steinar Solberg, Lars Jørgensen, Odd Terje Brustugun, Cecilie Essholt Kiserud, Åslaug Helland

Site disparities in apoptotic variants as predictors of risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck

• Open Access
• Research article

Yan Sun, Wenbin Yu, Erich M. Sturgis, Wei Peng, Dapeng Lei, Qingyi Wei, Xicheng Song, Guojun Li

Evaluation of TgH(CX3CR1-EGFP) mice implanted with mCherry-GL261 cells as an in vivo model for morphometrical analysis of glioma-microglia interaction

• Open Access
• Research article

Fernando F. B. Resende, Xianshu Bai, Elaine Aparecida Del Bel, Frank Kirchhoff, Anja Scheller, Ricardo Titze-de-Almeida

Computerized tomography angiography in preoperative assessment of intravenous leiomyomatosis extending to inferior vena cava and heart

• Open Access
• Research article

Ting Gui, Qiuhong Qian, Dongyan Cao, Jiaxin Yang, Ping Peng, Keng Shen

A pharmacogenetic pilot study reveals MTHFR, DRD3, and MDR1 polymorphisms as biomarker candidates for slow atorvastatin metabolizers

• Open Access
• Research article

Rafael B. R. León-Cachón, Jorge A. Ascacio-Martínez, María E. Gamino-Peña, Ricardo M. Cerda-Flores, Irene Meester, Hugo L. Gallardo-Blanco, Magdalena Gómez-Silva, Everardo Piñeyro-Garza, Hugo A. Barrera-Saldaña

Molecular pathways leading to loss of skeletal muscle mass in cancer cachexia – can findings from animal models be translated to humans?

• Open Access
• Review

Tara C. Mueller, Jeannine Bachmann, Olga Prokopchuk, Helmut Friess, Marc E. Martignoni

Using gene expression from urine sediment to diagnose prostate cancer: development of a new multiplex mRNA urine test and validation of current biomarkers

• Open Access
• Research article

Lourdes Mengual, Juan José Lozano, Mercedes Ingelmo-Torres, Laura Izquierdo, Mireia Musquera, María José Ribal, Antonio Alcaraz

Prediction of anticancer molecules using hybrid model developed on molecules screened against NCI-60 cancer cell lines

• Open Access
• Research article

Harinder Singh, Rahul Kumar, Sandeep Singh, Kumardeep Chaudhary, Ankur Gautam, Gajendra P. S. Raghava

Tumor slice culture system to assess drug response of primary breast cancer

• Open Access
• Research article

Kishan A. T. Naipal, Nicole S. Verkaik, Humberto Sánchez, Carolien H. M. van Deurzen, Michael A. den Bakker, Jan H.J. Hoeijmakers, Roland Kanaar, Maaike P.G. Vreeswijk, Agnes Jager, Dik C. van Gent

Evaluating early response of cervical cancer under concurrent chemo-radiotherapy by intravoxel incoherent motion MR imaging

• Open Access
• Research article

Li Zhu, Lijing Zhu, Hua Shi, Huanhuan Wang, Jing Yan, Baorui Liu, Weibo Chen, Jian He, Zhengyang Zhou, Xiaofeng Yang, Tian Liu

Inflammatory biomarker score and cancer: A population-based prospective cohort study

• Open Access
• Research article

Leavitt Morrison, Jari A. Laukkanen, Kimmo Ronkainen, Sudhir Kurl, Jussi Kauhanen, Adetunji T. Toriola

Chemotherapy with BCNU in recurrent glioma: Analysis of clinical outcome and side effects in chemotherapy-naïve patients

• Open Access
• Research article

Christine Jungk, Despina Chatziaslanidou, Rezvan Ahmadi, David Capper, Justo Lorenzo Bermejo, Janina Exner, Andreas von Deimling, Christel Herold-Mende, Andreas Unterberg

Capecitabine in the routine first-line treatment of elderly patients with advanced colorectal cancer - results from a non-interventional observation study

• Open Access
• Research article

Alexander Stein, Julia Quidde, Jan Klaus Schröder, Thomas Göhler, Barbara Tschechne, Annette-Rosel Valdix, Heinz-Gert Höffkes, Silke Schirrmacher-Memmel, Tim Wohlfarth, Axel Hinke, Andreas Engelen, Dirk Arnold

Lack of association between polymorphisms in the CYP1A2 gene and risk of cancer: evidence from meta-analyses

• Open Access
• Research article

Vladimir Vukovic, Carolina Ianuale, Emanuele Leoncini, Roberta Pastorino, Maria Rosaria Gualano, Rosarita Amore, Stefania Boccia

Impact of Bevacizumab on parenchymal damage and functional recovery of the liver in patients with colorectal liver metastases

• Open Access
• Research article

Andreas M. Volk, Johannes Fritzmann, Christoph Reissfelder, Georg F. Weber, Jürgen Weitz, Nuh N. Rahbari

HOX transcription factors are potential targets and markers in malignant mesothelioma

• Open Access
• Research article

Richard Morgan, Guy Simpson, Sophie Gray, Cheryl Gillett, Zsuzsanna Tabi, James Spicer, Kevin J. Harrington, Hardev S. Pandha

Regulation of the tumour suppressor PDCD4 by miR-499 and miR-21 in oropharyngeal cancers

• Open Access
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Xiaoying Zhang, Harriet Gee, Barbara Rose, C. Soon Lee, Jonathan Clark, Michael Elliott, Jennifer R. Gamble, Murray J. Cairns, Adrian Harris, Samantha Khoury, Nham Tran

Parallelism of DOG1 expression with recurrence risk in gastrointestinal stromal tumors bearing KIT or PDGFRA mutations

• Open Access
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Francesca Maria Rizzo, Raffaele Palmirotta, Andrea Marzullo, Nicoletta Resta, Mauro Cives, Marco Tucci, Franco Silvestris

Distinct genomic and epigenomic features demarcate hypomethylated blocks in colon cancer

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Mahfuza Sharmin, Héctor Corrada Bravo, Sridhar Hannenhalli

Comparative immunogenicity and structural analysis of epitopes of different bacterial L-asparaginases

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Vadim S. Pokrovsky, Marat D. Kazanov, Ilya N. Dyakov, Marina V. Pokrovskaya, Svetlana S. Aleksandrova

Establishment of a patient-derived intrahepatic cholangiocarcinoma xenograft model with KRAS mutation

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Giuliana Cavalloni, Caterina Peraldo-Neia, Francesco Sassi, Giovanna Chiorino, Ivana Sarotto, Massimo Aglietta, Francesco Leone

A phase II study of Epirubicin in oxaliplatin-resistant patients with metastatic colorectal cancer and TOP2A gene amplification

• Open Access
• Study protocol

Line S. Tarpgaard, Camilla Qvortrup, Sune B. Nygård, Signe L. Nielsen, Diana R. Andersen, Niels Frank Jensen, Jan Stenvang, Sönke Detlefsen, Nils Brünner, Per Pfeiffer

A nomogram for predicting the likelihood of lymph node metastasis in early gastric patients

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Zhixue Zheng, Yinan Zhang, Lianhai Zhang, Ziyu Li, Xiaojiang Wu, Yiqiang Liu, Zhaode Bu, Jiafu Ji

Effects of receptor for advanced glycation endproducts on microvessel formation in endometrial cancer

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Lu Zheng, Da Li, Yi-Ming Zhou, Hui Yang, Di Cheng, Xiao-Xin Ma

Organic Cation Transporter 1 (OCT1) mRNA expression in hepatocellular carcinoma as a biomarker for sorafenib treatment

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Daniel Grimm, Jonas Lieb, Veronika Weyer, Johanna Vollmar, Felix Darstein, Anja Lautem, Maria Hoppe-Lotichius, Sandra Koch, Arno Schad, Jörn M. Schattenberg, Marcus A. Wörns, Arndt Weinmann, Peter R. Galle, Tim Zimmermann

The prognostic value of stromal and epithelial periostin expression in human breast cancer: correlation with clinical pathological features and mortality outcome

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P. V. Nuzzo, A. Rubagotti, L. Zinoli, S. Salvi, S. Boccardo, F. Boccardo

Attitudes towards the Faecal Occult Blood Test (FOBT) versus the Faecal Immunochemical Test (FIT) for colorectal cancer screening: perceived ease of completion and disgust

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Julie A. Chambers, Alana S. Callander, Rebecca Grangeret, Ronan E. O’Carroll

Select Bcl-2 antagonism restores chemotherapy sensitivity in high-risk neuroblastoma

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Rachel Tanos, Dipan Karmali, Srilatha Nalluri, Kelly C. Goldsmith

Follicular thyroid carcinoma but not adenoma recruits tumor-associated macrophages by releasing CCL15

• Open Access
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Feng-Jiao Huang, Xiao-Yi Zhou, Lei Ye, Xiao-Chun Fei, Shu Wang, Weiqing Wang, Guang Ning

Erratum to: Differences in TGF-β1 signaling and clinicopathologic characteristics of histologic subtypes of gastric cancer

• Open Access
• Erratum

Kyung Ho Pak, Dong Hoon Kim, Hyunki Kim, Do Hyung Lee, Jae-Ho Cheong

BMC Cancer reviewer acknowledgement 2015

• Open Access
• Reviewer Acknowledgement

Dafne Solera

MiR-193b promotes autophagy and non-apoptotic cell death in oesophageal cancer cells

• Open Access
• Research article

Michelle J. Nyhan, Tracey R. O’Donovan, Antonius W. M. Boersma, Erik A. C. Wiemer, Sharon L. McKenna

Expression and promotor hypermethylation of miR-34a in the various histological subtypes of ovarian cancer

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Gabriel Schmid, Sara Notaro, Daniel Reimer, Samira Abdel-Azim, Michaela Duggan-Peer, Jessica Holly, Heidi Fiegl, Julia Rössler, Annemarie Wiedemair, Nicole Concin, Peter Altevogt, Christian Marth, Alain Gustave Zeimet

RETRACTED ARTICLE: BCORL1 is an independent prognostic marker and contributes to cell migration and invasion in human hepatocellular carcinoma

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Guozhi Yin, Zhikui Liu, Yufeng Wang, Changwei Dou, Chao Li, Wei Yang, Yingmin Yao, Qingguang Liu, Kangsheng Tu

Epidemiology of childhood and adolescent cancer in Bangladesh, 2001–2014

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Mohammad Sorowar Hossain, Mamtaz Begum, Md Mahmuduzzaman Mian, Shameema Ferdous, Shahinur Kabir, Humayun Kabir Sarker, Sabina Karim, Salma Choudhury, Asaduzzaman Khan, Zohora Jameela Khan, Henrike E. Karim-Kos

Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification

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Jieyi Wang, Liliane Goetsch, Lora Tucker, Qian Zhang, Alexandra Gonzalez, Kedar S. Vaidya, Anatol Oleksijew, Erwin Boghaert, Minghao Song, Irina Sokolova, Ekaterina Pestova, Mark Anderson, William N. Pappano, Peter Ansell, Anahita Bhathena, Louie Naumovski, Nathalie Corvaia, Edward B. Reilly

Isolated tumor cells in stage I & II colon cancer patients are associated with significantly worse disease-free and overall survival

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B. Weixler, R. Warschkow, U. Güller, A. Zettl, U. von Holzen, B. M. Schmied, M. Zuber

The combination of blue dye and radioisotope versus radioisotope alone during sentinel lymph node biopsy for breast cancer: a systematic review

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Pei-Sheng He, Feng Li, Guan-Hua Li, Can Guo, Tian-Jin Chen

MiRNA-146b-5p upregulates migration and invasion of different Papillary Thyroid Carcinoma cells

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Cilene Rebouças Lima, Murilo Vieira Geraldo, Cesar Seigi Fuziwara, Edna Teruko Kimura, Marinilce Fagundes Santos

Prognostic value of a computer-aided diagnosis system involving bone scans among men treated with docetaxel for metastatic castration-resistant prostate cancer

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Koichi Uemura, Yasuhide Miyoshi, Takashi Kawahara, Shuko Yoneyama, Yusuke Hattori, Jun-ichi Teranishi, Keiichi Kondo, Masatoshi Moriyama, Shigeo Takebayashi, Yumiko Yokomizo, Masahiro Yao, Hiroji Uemura, Kazumi Noguchi

Bevacizumab for metachronous metastatic colorectal cancer: a reflection of community based practice

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L. G. E. M. Razenberg, Y. R. B. M. van Gestel, I. H. J. T. de Hingh, O. J. L. Loosveld, G. Vreugdenhil, L. V. Beerepoot, G. J. Creemers, V. E. P. P. Lemmens

Pretreatment neutrophil-to-lymphocyte ratio predicts the prognosis in patients with metastatic prostate cancer

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Takashi Kawahara, Yumiko Yokomizo, Yusuke Ito, Hiroki Ito, Hitoshi Ishiguro, Jun-ichi Teranishi, Kazuhide Makiyama, Yasuhide Miyoshi, Hiroshi Miyamoto, Masahiro Yao, Hiroji Uemura

Characterising timing and pattern of relapse following surgery for localised oesophagogastric adenocarcinoma: a retrospective study

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Sing Yu Moorcraft, Elisa Fontana, David Cunningham, Clare Peckitt, Tom Waddell, Elizabeth C. Smyth, William Allum, Jeremy Thompson, Sheela Rao, David Watkins, Naureen Starling, Ian Chau

Promoter methylation of ITF2, but not APC, is associated with microsatellite instability in two populations of colorectal cancer patients

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Andrea J. Savio, Darshana Daftary, Elizabeth Dicks, Daniel D. Buchanan, Patrick S. Parfrey, Joanne P. Young, Daniel Weisenberger, Roger C. Green, Steven Gallinger, John R. McLaughlin, Julia A. Knight, Bharati Bapat

Prognostic value of the distance between the primary tumor and brainstem in the patients with locally advanced nasopharyngeal carcinoma

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Yuxiang He, Ying Wang, Lin Shen, Yajie Zhao, Pengfei Cao, Mingjun Lei, Dengming Chen, Tubao Yang, Liangfang Shen, Shousong Cao

MB3W1 is an orthotopic xenograft model for anaplastic medulloblastoma displaying cancer stem cell- and Group 3-properties

• Open Access
• Technical advance

Sebastian Dietl, Stefanie Schwinn, Susanne Dietl, Simone Riedel, Frank Deinlein, Stefan Rutkowski, Andre O. von Bueren, Jürgen Krauss, Tilmann Schweitzer, Giles H. Vince, Daniel Picard, Matthias Eyrich, Andreas Rosenwald, Vijay Ramaswamy, Michael D. Taylor, Marc Remke, Camelia M. Monoranu, Andreas Beilhack, Paul G. Schlegel, Matthias Wölfl

Predictive and prognostic value of PET/CT imaging post-chemoradiotherapy and clinical decision-making consequences in locally advanced head & neck squamous cell carcinoma: a retrospective study

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Ryul Kim, Chan-Young Ock, Bhumsuk Keam, Tae Min Kim, Jin Ho Kim, Jin Chul Paeng, Seong Keun Kwon, J. Hun Hah, Tack-Kyun Kwon, Dong-Wan Kim, Hong-Gyun Wu, Myung-Whun Sung, Dae Seog Heo

Erratum to: Results of multicenter double-blind placebo-controlled phase II clinical trial of Panagen preparation to evaluate its leukostimulatory activity and formation of the adaptive immune response in patients with stage II-IV breast cancer

• Open Access
• Erratum

Anastasia S. Proskurina, Tatiana S. Gvozdeva, Ekaterina A. Alyamkina, Evgenia V. Dolgova, Konstantin E. Orishchenko, Valeriy P. Nikolin, Nelly A. Popova, Sergey V. Sidorov, Elena R. Chernykh, Alexandr A. Ostanin, Olga Y. Leplina, Victoria V. Dvornichenko, Dmitriy M. Ponomarenko, Galina S. Soldatova, Nikolay A. Varaksin, Tatiana G. Ryabicheva, Peter N. Uchakin, Stanislav N. Zagrebelniy, Vladimir A. Rogachev, Sergey S. Bogachev, Mikhail A. Shurdov

Paraneoplastic lipase and amylase production in a patient with small-cell lung cancer: case report

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• Case report

Andrea Casadei Gardini, Marita Mariotti, Alessandro Lucchesi, Sara Pini, Martina Valgiusti, Sara Bravaccini, Angelo Del Monte, Marco Angelo Burgio, Giorgia Marisi, Dino Amadori, Giovanni Luca Frassineti

Breast cancer literacy among higher secondary students: results from a cross-sectional study in Western Nepal

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Parash Mani Bhandari, Kiran Thapa, Sarmila Dhakal, Shristi Bhochhibhoya, Rashmi Deuja, Pawan Acharya, Shiva Raj Mishra

The impact of KRAS mutations on prognosis in surgically resected colorectal cancer patients with liver and lung metastases: a retrospective analysis

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Hae Su Kim, Jin Seok Heo, Jeeyun Lee, Ji Yun Lee, Min-Young Lee, Sung Hee Lim, Woo Yong Lee, Seok Hyung Kim, Yoon Ah Park, Yong Beom Cho, Seong Hyeon Yun, Seung Tae Kim, Joon Oh Park, Ho Yeong Lim, Yong Soo Choi, Woo Il Kwon, Hee Cheol Kim, Young Suk Park

Phase II study on the efficacy and safety of Lapatinib administered beyond disease progression and combined with vinorelbine in HER-2/neu– positive advanced breast cancer: results of the CECOG LaVie trial

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Christiane Thallinger, Istvan Lang, Cvetka Grasic Kuhar, Rupert Bartsch, Christian F. Singer, Lubos Petruzelka, Bohuslav Melichar, Regina Knittelfelder, Thomas Brodowicz, Christoph Zielinski

Methodology of health-related quality of life analysis in phase III advanced non-small-cell lung cancer clinical trials: a critical review

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Frédéric Fiteni, Amélie Anota, Virginie Westeel, Franck Bonnetain

An 8-gene mRNA expression profile in circulating tumor cells predicts response to aromatase inhibitors in metastatic breast cancer patients

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Esther A. Reijm, Anieta M. Sieuwerts, Marcel Smid, Joan Bolt-de Vries, Bianca Mostert, Wendy Onstenk, Dieter Peeters, Luc Y. Dirix, Caroline M. Seynaeve, Agnes Jager, Felix E. de Jongh, Paul Hamberg, Anne van Galen, Jaco Kraan, Maurice P. H. M. Jansen, Jan W. Gratama, John A. Foekens, John W. M. Martens, Els M. J. J. Berns, Stefan Sleijfer

Systemic inflammation is an independent predictive marker of clinical outcomes in mucosal squamous cell carcinoma of the head and neck in oropharyngeal and non-oropharyngeal patients

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Kellie A. Charles, Benjamin D. W. Harris, Carol R. Haddad, Stephen J. Clarke, Alex Guminski, Mark Stevens, Tristan Dodds, Anthony J. Gill, Michael Back, David Veivers, Thomas Eade

Prolonged pemetrexed pretreatment augments persistence of cisplatin-induced DNA damage and eliminates resistant lung cancer stem-like cells associated with EMT

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Colin Charles Tièche, Ren-Wang Peng, Patrick Dorn, Laurène Froment, Ralph Alexander Schmid, Thomas Michael Marti

Combination of metformin and 5-aminosalicylic acid cooperates to decrease proliferation and induce apoptosis in colorectal cancer cell lines

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Mona M. Saber, May A. Galal, Afaf A. Ain-Shoka, Samia A. Shouman

CXCR4-SDF-1 interaction potentially mediates trafficking of circulating tumor cells in primary breast cancer

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M. Mego, D. Cholujova, G. Minarik, T. Sedlackova, P. Gronesova, M. Karaba, J. Benca, S. Cingelova, Z. Cierna, D. Manasova, D. Pindak, J. Sufliarsky, M. Cristofanilli, J. M. Reuben, J. Mardiak

Prognostic value of the bone scan index using a computer-aided diagnosis system for bone scans in hormone-naive prostate cancer patients with bone metastases

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Yasuhide Miyoshi, Shuko Yoneyama, Takashi Kawahara, Yusuke Hattori, Jun-ichi Teranishi, Keiichi Kondo, Masatoshi Moriyama, Shigeo Takebayashi, Yumiko Yokomizo, Masahiro Yao, Hiroji Uemura, Kazumi Noguchi

Stage of breast cancer at diagnosis in New Zealand: impacts of socio-demographic factors, breast cancer screening and biology

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Sanjeewa Seneviratne, Ross Lawrenson, Vernon Harvey, Reena Ramsaroop, Mark Elwood, Nina Scott, Diana Sarfati, Ian Campbell

Pancreatic panniculitis in a patient with pancreatic-type acinar cell carcinoma of the liver – case report and review of literature

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• Case report

Sebastian Zundler, Ramona Erber, Abbas Agaimy, Arndt Hartmann, Franklin Kiesewetter, Deike Strobel, Markus F. Neurath, Dane Wildner

A novel anti-p21Ras scFv antibody reacting specifically with human tumour cell lines and primary tumour tissues

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Ju-Lun Yang, Du-Xian Liu, Shi-Jian Zhen, Yun-Gang Zhou, Dai-Jun Zhang, Li-Ying Yang, Hao-Bing Chen, Qiang Feng

TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC trial): study protocol for a randomized controlled trial

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• Study protocol

M. M. Koeneman, A. J. Kruse, L. F. S. Kooreman, A. zur Hausen, A. H. N. Hopman, S. J. S. Sep, T. Van Gorp, B. F. M. Slangen, H. J. van Beekhuizen, M. van de Sande, C. G. Gerestein, H. W. Nijman, R. F. P. M. Kruitwagen

Associations between metabolic disorders and risk of cancer in Danish men and women – a nationwide cohort study

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Siv Mari Berger, Gunnar Gislason, Lynn L. Moore, Charlotte Andersson, Christian Torp-Pedersen, Gerald V. Denis, Michelle Dalgas Schmiegelow

Transketolase-like 1 ectopic expression is associated with DNA hypomethylation and induces the Warburg effect in melanoma cells

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Aparna Jayachandran, Pu-Han Lo, Anderly C. Chueh, Prashanth Prithviraj, Ramyar Molania, Mercedes Davalos-Salas, Matthew Anaka, Marzena Walkiewicz, Jonathan Cebon, Andreas Behren

Impact on clinical practice of the implementation of guidelines for the toxicity management of targeted therapies in kidney cancer. The protect-2 study

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Nuria Lainez, Jesús García-Donas, Emilio Esteban, Javier Puente, M. Isabel Sáez, Enrique Gallardo, Álvaro Pinto-Marín, Sergio Vázquez-Estévez, Luis León, Icíar García-Carbonero, Cristina Suárez-Rodríguez, Carmen Molins, Miguel A. Climent-Duran, Martín Lázaro-Quintela, Aranzazu González del Alba, María José Méndez-Vidal, Isabel Chirivella, Francisco J. Afonso, Marta López-Brea, Nuria Sala-González, Montserrat Domenech, Laura Basterretxea, Carmen Santander-Lobera, Irene Gil-Arnáiz, Ovidio Fernández, Cristina Caballero-Díaz, Begoña Mellado, David Marrupe, José García-Sánchez, Ricardo Sánchez-Escribano, Eva Fernández Parra, José C. Villa Guzmán, Esther Martínez-Ortega, María Belén González, Marina Morán, Beatriz Suarez-Paniagua, María J. Lecumberri, Daniel Castellano

METCAM/MUC18 is a novel tumor and metastasis suppressor for the human ovarian cancer SKOV3 cells

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Guang-Jer Wu, Guo-fang Zeng

A novel and accurate predictor of survival for patients with hepatocellular carcinoma after surgical resection: the neutrophil to lymphocyte ratio (NLR) combined with the aspartate aminotransferase/platelet count ratio index (APRI)

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Fei Ji, Yao Liang, Shun-Jun Fu, Zhi-Yong Guo, Man Shu, Shun-Li Shen, Shao-Qiang Li, Bao-Gang Peng, Li-Jian Liang, Yun-Peng Hua

Prognostic value of ERBB4 expression in patients with triple negative breast cancer

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Ji-Yeon Kim, Hae Hyun Jung, In-Gu Do, SooYoun Bae, Se Kyung Lee, Seok Won Kim, Jeong Eon Lee, Seok Jin Nam, Jin Seok Ahn, Yeon Hee Park, Young-Hyuck Im

Impact of postoperative daily image-guided intensity-modulated radiotherapy on overall and local progression-free survival in patients with oral cavity cancer

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Chen-Hsi Hsieh, Pei-Wei Shueng, Li-Ying Wang, Yu-Chuen Huang, Li-Jen Liao, Wu-Chia Lo, Yu-Chin Lin, Le-Jung Wu, Hui-Ju Tien

Platinum (IV)-fatty acid conjugates overcome inherently and acquired Cisplatin resistant cancer cell lines: an in-vitro study

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Einav Ratzon, Yousef Najajreh, Rami Salem, Hazem Khamaisie, Martin Ruthardt, Jamal Mahajna

IκBα mediates prostate cancer cell death induced by combinatorial targeting of the androgen receptor

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Sarah L. Carter, Margaret M. Centenera, Wayne D. Tilley, Luke A. Selth, Lisa M. Butler

Forkhead Box F1 promotes breast cancer cell migration by upregulating lysyl oxidase and suppressing Smad2/3 signaling

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Gisela Nilsson, Marie Kannius-Janson

Generation of an algorithm based on minimal gene sets to clinically subtype triple negative breast cancer patients

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• Technical advance

Brian Z. Ring, David R. Hout, Stephan W. Morris, Kasey Lawrence, Brock L. Schweitzer, Daniel B. Bailey, Brian D. Lehmann, Jennifer A. Pietenpol, Robert S. Seitz

Intraoperative optical coherence tomography for assessing human lymph nodes for metastatic cancer

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Ryan M. Nolan, Steven G. Adie, Marina Marjanovic, Eric J. Chaney, Fredrick A. South, Guillermo L. Monroy, Nathan D. Shemonski, Sarah J. Erickson-Bhatt, Ryan L. Shelton, Andrew J. Bower, Douglas G. Simpson, Kimberly A. Cradock, Z. George Liu, Partha S. Ray, Stephen A. Boppart

Breast cancer stem cell selectivity of synthetic nanomolar-active salinomycin analogs

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Xiaoli Huang, Björn Borgström, Sebastian Kempengren, Lo Persson, Cecilia Hegardt, Daniel Strand, Stina Oredsson

RNA disruption is associated with response to multiple classes of chemotherapy drugs in tumor cell lines

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Rashmi Narendrula, Kyle Mispel-Beyer, Baoqing Guo, Amadeo M. Parissenti, Laura B. Pritzker, Ken Pritzker, Twinkle Masilamani, Xiaohui Wang, Carita Lannér

Efficacy and safety of afatinib in Chinese patients with EGFR-mutated metastatic non-small-cell lung cancer (NSCLC) previously responsive to first-generation tyrosine-kinase inhibitors (TKI) and chemotherapy: comparison with historical cohort using erlotinib

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Victor H. F. Lee, Dennis K. C. Leung, Tim-Shing Choy, Ka-On Lam, Pui-Mei Lam, To-Wai Leung, Dora L. W. Kwong

KSHV gB associated RGD interactions promote attachment of cells by inhibiting the potential migratory signals induced by the disintegrin-like domain

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Hosni A. M. Hussein, Lia R. Walker, Shaw M. Akula

Distribution and prognosis of uncommon metastases from non-small cell lung cancer

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Fei-Yu Niu, Qing Zhou, Jin-Ji Yang, Wen-Zhao Zhong, Zhi-Hong Chen, Wei Deng, Yan-Yan He, Hua-Jun Chen, Zhu Zeng, E-E Ke, Ning Zhao, Na Zhang, Hui-Wen Sun, Qiu-Yi Zhang, Zhi Xie, Xu-Chao Zhang, Yi-Long Wu

Cyclopamine tartrate, an inhibitor of Hedgehog signaling, strongly interferes with mitochondrial function and suppresses aerobic respiration in lung cancer cells

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Md Maksudul Alam, Sagar Sohoni, Sarada Preeta Kalainayakan, Massoud Garrossian, Li Zhang

Genetic and cellular studies highlight that A Disintegrin and Metalloproteinase 19 is a protective biomarker in human prostate cancer

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Gerard Hoyne, Caroline Rudnicka, Qing-Xiang Sang, Mark Roycik, Sarah Howarth, Peter Leedman, Markus Schlaich, Patrick Candy, Vance Matthews

Molecular association of glucose-6-phosphate isomerase and pyruvate kinase M2 with glyceraldehyde-3-phosphate dehydrogenase in cancer cells

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Mahua R. Das, Arup K. Bag, Shekhar Saha, Alok Ghosh, Sumit K. Dey, Provas Das, Chitra Mandal, Subhankar Ray, Saikat Chakrabarti, Manju Ray, Siddhartha S. Jana

A phase 1b study of Selumetinib in combination with Cisplatin and Gemcitabine in advanced or metastatic biliary tract cancer: the ABC-04 study

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John Bridgewater, Andre Lopes, Sandra Beare, Marian Duggan, Dymphna Lee, Maravic Ricamara, Delyth McEntee, Ajithkumar Sukumaran, Harpreet Wasan, Juan W. Valle

Evaluation of serum and tissue levels of VAP-1 in colorectal cancer

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Stephen T. Ward, Christopher J. Weston, Emma L. Shepherd, Rahul Hejmadi, Tariq Ismail, David H. Adams

The anti-oxidative transcription factor Nuclear factor E2 related factor-2 (Nrf2) counteracts TGF-β1 mediated growth inhibition of pancreatic ductal epithelial cells -Nrf2 as determinant of pro-tumorigenic functions of TGF-β1

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Geeske Genrich, Marcus Kruppa, Lennart Lenk, Ole Helm, Anna Broich, Sandra Freitag-Wolf, Christoph Röcken, Bence Sipos, Heiner Schäfer, Susanne Sebens

Correlation between S-1 treatment outcome and expression of biomarkers for refractory thymic carcinoma

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Yusuke Okuma, Yukio Hosomi, Shingo Miyamoto, Masahiko Shibuya, Tatsuru Okamura, Tsunekazu Hishima

Change in weight and waist circumference and risk of colorectal cancer: results from the Melbourne Collaborative Cohort Study

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Amalia Karahalios, Julie A. Simpson, Laura Baglietto, Robert J. MacInnis, Allison M. Hodge, Graham G. Giles, Dallas R. English

Combined hepatocellular carcinoma and cholangiocarcinoma (biphenotypic) tumors: clinical characteristics, imaging features of contrast-enhanced ultrasound and computed tomography

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Rui Li, Dan Yang, Chun-Lin Tang, Ping Cai, Kuan-sheng Ma, Shi-Yi Ding, Xiao-Hang Zhang, De-Yu Guo, Xiao-Chu Yan

Distribution and features of hematological malignancies in Eastern Morocco: a retrospective multicenter study over 5 years

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Mounia Elidrissi Errahhali, Manal Elidrissi Errahhali, Redouane Boulouiz, Meryem Ouarzane, Mohammed Bellaoui

Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448

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Oluwaseun Adebayo Bamodu, Wen-Chien Huang, Wei-Hwa Lee, Alexander Wu, Liang Shun Wang, Michael Hsiao, Chi-Tai Yeh, Tsu-Yi Chao

Analytical performance of a bronchial genomic classifier

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Zhanzhi Hu, Duncan Whitney, Jessica R. Anderson, Manqiu Cao, Christine Ho, Yoonha Choi, Jing Huang, Robert Frink, Kate Porta Smith, Robert Monroe, Giulia C. Kennedy, P. Sean Walsh

Treatment and outcome of 32 patients with distant metastases of Hürthle cell thyroid carcinoma: a single-institution experience

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Nikola Besic, Andreja Schwarzbartl-Pevec, Barbara Vidergar-Kralj, Tea Crnic, Barbara Gazic, Maja Marolt Music

Differences in predictions of ODE models of tumor growth: a cautionary example

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Hope Murphy, Hana Jaafari, Hana M. Dobrovolny

Effect of vaccination age on cost-effectiveness of human papillomavirus vaccination against cervical cancer in China

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Yi-Jun Liu, Qian Zhang, Shang-Ying Hu, Fang-Hui Zhao

Analysis of functional germline variants in APOBEC3 and driver genes on breast cancer risk in Moroccan study population

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Chaymaa Marouf, Stella Göhler, Miguel Inacio Da Silva Filho, Omar Hajji, Kari Hemminki, Sellama Nadifi, Asta Försti

Randomized phase III trial of APF530 versus palonosetron in the prevention of chemotherapy-induced nausea and vomiting in a subset of patients with breast cancer receiving moderately or highly emetogenic chemotherapy

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Ralph Boccia, Erin O’Boyle, William Cooper

Myeloproliferative neoplasms (MPNs) have a significant impact on patients’ overall health and productivity: the MPN Landmark survey

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Ruben Mesa, Carole B. Miller, Maureen Thyne, James Mangan, Sara Goldberger, Salman Fazal, Xiaomei Ma, Wendy Wilson, Dilan C. Paranagama, David G. Dubinski, John Boyle, John O. Mascarenhas

Vimentin and Ki67 expression in circulating tumour cells derived from castrate-resistant prostate cancer

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C. R. Lindsay, S. Le Moulec, F. Billiot, Y. Loriot, M. Ngo-Camus, P. Vielh, K. Fizazi, C. Massard, F. Farace

Critical weight loss predicts poor prognosis in nasopharyngeal carcinoma

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Qi Zeng, Lu-Jun Shen, Xiang Guo, Xin-Ming Guo, Chao-Nan Qian, Pei-Hong Wu

Clinical application of genomic profiling to find druggable targets for adolescent and young adult (AYA) cancer patients with metastasis

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Soojin Cha, Jeongeun Lee, Jong-Yeon Shin, Ji-Yeon Kim, Sung Hoon Sim, Bhumsuk Keam, Tae Min Kim, Dong-Wan Kim, Dae Seog Heo, Se-Hoon Lee, Jong-Il Kim

More expression of BDNF associates with lung squamous cell carcinoma and is critical to the proliferation and invasion of lung cancer cells

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Si-yang Zhang, Lin-ping Hui, Chun-yan Li, Jian Gao, Ze-shi Cui, Xue-shan Qiu

Binimetinib inhibits MEK and is effective against neuroblastoma tumor cells with low NF1 expression

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Sarah E. Woodfield, Linna Zhang, Kathleen A. Scorsone, Yin Liu, Peter E. Zage

Cathepsin K induces platelet dysfunction and affects cell signaling in breast cancer - molecularly distinct behavior of cathepsin K in breast cancer

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Sheila Siqueira Andrade, Iuri Estrada Gouvea, Mariana Cristina C. Silva, Eloísa Dognani Castro, Cláudia A. A. de Paula, Debora Okamoto, Lilian Oliveira, Giovani Bravin Peres, Tatiana Ottaiano, Gil Facina, Afonso Celso Pinto Nazário, Antonio Hugo J. F. M. Campos, Edgar Julian Paredes-Gamero, Maria Juliano, Ismael D. C. G. da Silva, Maria Luiza V. Oliva, Manoel J. B. C. Girão

Clinical significance of AGE-RAGE axis in colorectal cancer: associations with glyoxalase-I, adiponectin receptor expression and prognosis

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Stratigoula Sakellariou, Paraskevi Fragkou, Georgia Levidou, Antonios N. Gargalionis, Christina Piperi, Georgia Dalagiorgou, Christos Adamopoulos, Angelica Saetta, George Agrogiannis, Irini Theohari, Stavros Sougioultzis, Panagiota Tsioli, Ioannis Karavokyros, Nikolaos Tsavaris, Ioannis D. Kostakis, Adamantia Zizi-Serbetzoglou, Gerasimos P. Vandoros, Efstratios Patsouris, Penelope Korkolopoulou

POU5F1/Oct-4 expression in breast cancer tissue is significantly associated with non-sentinel lymph node metastasis

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Shouliang Cai, Shugang Geng, Feng Jin, Jisheng Liu, Chang Qu, Bo Chen

The anti-fibrotic agent pirfenidone synergizes with cisplatin in killing tumor cells and cancer-associated fibroblasts

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Melanie Mediavilla-Varela, Kingsley Boateng, David Noyes, Scott J. Antonia

Erratum to: IκBα mediates prostate cancer cell death induced by combinatorial targeting of the androgen receptor

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• Erratum

Sarah L. Carter, Margaret M. Centenera, Wayne D. Tilley, Luke A. Selth, Lisa M. Butler

A pilot study to compare the detection of HPV-16 biomarkers in salivary oral rinses with tumour p16INK4a expression in head and neck squamous cell carcinoma patients

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Ryan C. Chai, Yenkai Lim, Ian H. Frazer, Yunxia Wan, Christopher Perry, Lee Jones, Duncan Lambie, Chamindie Punyadeera

Patterns of failure after use of 18F-FDG PET/CT in integration of extended-field chemo-IMRT and 3D-brachytherapy plannings for advanced cervical cancers with extensive lymph node metastases

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Yih-Lin Chung, Cheng-Fang Horng, Pei-Ing Lee, Fong-Lin Chen

Stroke related to androgen deprivation therapy for prostate cancer: a meta-analysis and systematic review

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Fanzheng Meng, Shimiao Zhu, Jinsheng Zhao, Larissa Vados, Lei Wang, Yusheng Zhao, Dan Zhao, Yuanjie Niu

Erratum to: Population attributable risks of modifiable reproductive factors for breast and ovarian cancers in Korea

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• Erratum

Boyoung Park, Sohee Park, Hai-Rim Shin, Aesun Shin, Yohwan Yeo, Ji-Yeob Choi, Kyu-Won Jung, Byoung-Gie Kim, Yong-Man Kim, Dong-Young Noh, Sei-Hyun Ahn, Jae Weon Kim, Sokbom Kang, Jae Hoon Kim, Tae Jin Kim, Daehee Kang, Keun-Young Yoo, Sue K. Park

Primary diffuse leptomeningeal gliomatosis as a rare cause of pain in cervical spine

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• Case report

Štefan Sivák, Ema Kantorová, Egon Kurča, Juraj Marcinek, Pavol Slávik, Jozef Michalik, Vladimír Nosáľ

A randomised phase II trial of Stereotactic Ablative Fractionated radiotherapy versus Radiosurgery for Oligometastatic Neoplasia to the lung (TROG 13.01 SAFRON II)

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• Study protocol

Shankar Siva, Tomas Kron, Mathias Bressel, Marion Haas, Tao Mai, Shalini Vinod, Giuseppe Sasso, Wenchang Wong, Hien Le, Thomas Eade, Nicholas Hardcastle, Brent Chesson, Daniel Pham, Morten Høyer, Rebecca Montgomery, David Ball

On Predicting lung cancer subtypes using ‘omic’ data from tumor and tumor-adjacent histologically-normal tissue

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Arturo López Pineda, Henry Ato Ogoe, Jeya Balaji Balasubramanian, Claudia Rangel Escareño, Shyam Visweswaran, James Gordon Herman, Vanathi Gopalakrishnan

Neutrophil-to-lymphocyte ratio is a prognostic marker in bladder cancer patients after radical cystectomy

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Takashi Kawahara, Kazuhiro Furuya, Manami Nakamura, Kentaro Sakamaki, Kimito Osaka, Hiroki Ito, Yusuke Ito, Koji Izumi, Shinji Ohtake, Yasuhide Miyoshi, Kazuhide Makiyama, Noboru Nakaigawa, Takeharu Yamanaka, Hiroshi Miyamoto, Masahiro Yao, Hiroji Uemura

Mitogen-activated protein kinase signaling causes malignant melanoma cells to differentially alter extracellular matrix biosynthesis to promote cell survival

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Anna Afasizheva, Alexus Devine, Heather Tillman, King Leung Fung, Wilfred D. Vieira, Benjamin H. Blehm, Yorihisa Kotobuki, Ben Busby, Emily I. Chen, Kandice Tanner

Local iron homeostasis in the breast ductal carcinoma microenvironment

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Oriana Marques, Graça Porto, Alexandra Rêma, Fátima Faria, Arnaud Cruz Paula, Maria Gomez-Lazaro, Paula Silva, Berta Martins da Silva, Carlos Lopes

Intensive care unit prognostic factors in critically ill patients with advanced solid tumors: a 3-year retrospective study

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Rui Xia, Donghao Wang

Chronic ethanol feeding promotes azoxymethane and dextran sulfate sodium-induced colonic tumorigenesis potentially by enhancing mucosal inflammation

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Pradeep K. Shukla, Kamaljit K. Chaudhry, Hina Mir, Ruchika Gangwar, Nikki Yadav, Bhargavi Manda, Avtar S. Meena, RadhaKrishna Rao

Patterns of recurrence after selective postoperative radiation therapy for patients with head and neck squamous cell carcinoma

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Naoya Murakami, Fumihiko Matsumoto, Seiichi Yoshimoto, Yoshinori Ito, Taisuke Mori, Takao Ueno, Keisuke Tuchida, Tairo Kashihara, Kazuma Kobayashi, Ken Harada, Mayuka Kitaguchi, Shuhei Sekii, Rei Umezawa, Kana Takahashi, Koji Inaba, Hiroshi Igaki, Jun Itami

Targeting Rad50 sensitizes human nasopharyngeal carcinoma cells to radiotherapy

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Lihong Chang, Jiancong Huang, Kai Wang, Jingjia Li, Ruicheng Yan, Ling Zhu, Jin Ye, Xifu Wu, Shimin Zhuang, Daqing Li, Gehua Zhang

Anti-vascular effects of the cytosolic phospholipase A2 inhibitor AVX235 in a patient-derived basal-like breast cancer model

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Eugene Kim, Hanna Maja Tunset, Jana Cebulla, Riyas Vettukattil, Heidi Helgesen, Astrid Jullumstrø Feuerherm, Olav Engebråten, Gunhild Mari Mælandsmo, Berit Johansen, Siver Andreas Moestue

The efficacy of iodine-125 permanent brachytherapy versus intensity-modulated radiation for inoperable salivary gland malignancies: study protocol of a randomised controlled trial

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• Study protocol

Shu-Ming Liu, Hai-Bo Wang, Yan Sun, Yan Shi, Jie Zhang, Ming-Wei Huang, Lei Zheng, Xiao-Ming Lv, Bao-Min Zheng, Kathleen H. Reilly, Xiao-Yan Yan, Ping Ji, Yang-feng Wu, Jian-Guo Zhang

Snail heterogeneity in clear cell renal cell carcinoma

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Laura Zaldumbide, Asier Erramuzpe, Rosa Guarch, Rafael Pulido, Jesús M. Cortés, José I. López

Characterization of various cell lines from different ampullary cancer subtypes and cancer associated fibroblast-mediated responses

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Zon Weng Lai, Louisa Bolm, Hannah Fuellgraf, Martin L. Biniossek, Frank Makowiec, Ulrich Theodor Hopt, Martin Werner, Tobias Keck, Dirk Bausch, Claudio Sorio, Aldo Scarpa, Oliver Schilling, Peter Bronsert, Ulrich Friedrich Wellner

Birth rates among male cancer survivors and mortality rates among their offspring: a population-based study from Sweden

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Siau-Wei Tang, Jenny Liu, Lester Juay, Kamila Czene, Hui Miao, Agus Salim, Helena M Verkooijen, Mikael Hartman

Prognostic factors affecting the risk of thoracic progression in extensive-stage small cell lung cancer

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Tomoya Fukui, Michiko Itabashi, Mikiko Ishihara, Yasuhiro Hiyoshi, Masashi Kasajima, Satoshi Igawa, Jiichiro Sasaki, Noriyuki Masuda

Chronic myeloid leukemia incidence, survival and accessibility of tyrosine kinase inhibitors: a report from population-based Lithuanian haematological disease registry 2000–2013

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Tumas Beinortas, Ilma Tavorienė, Tadas Žvirblis, Rolandas Gerbutavičius, Mindaugas Jurgutis, Laimonas Griškevičius

GMP-grade α-TEA lysine salt: a 28-Day oral toxicity and toxicokinetic study with a 28-Day recovery period in Beagle dogs

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Bella S. Guerrouahen, Tobias Hahn, Zefora Alderman, Brendan Curti, Walter Urba, Emmanuel T. Akporiaye

Improving gastric cancer preclinical studies using diverse in vitro and in vivo model systems

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Hae Ryung Chang, Hee Seo Park, Young Zoo Ahn, Seungyoon Nam, Hae Rim Jung, Sungjin Park, Sang Jin Lee, Curt Balch, Garth Powis, Ja-Lok Ku, Yon Hui Kim

miRNA profiling, detection of BRAF V600E mutation and RET-PTC1 translocation in patients from Novosibirsk oblast (Russia) with different types of thyroid tumors

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Sergei E. Titov, Mikhail K. Ivanov, Elena V. Karpinskaya, Elena V. Tsivlikova, Sergei P. Shevchenko, Yulia A. Veryaskina, Larisa G. Akhmerova, Tatiana L. Poloz, Olesya A. Klimova, Lyudmila F. Gulyaeva, Igor F. Zhimulev, Nikolay N. Kolesnikov

Testing the effects of narrative and play on physical activity among breast cancer survivors using mobile apps: study protocol for a randomized controlled trial

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• Study protocol

Elizabeth J. Lyons, Tom Baranowski, Karen M. Basen-Engquist, Zakkoyya H. Lewis, Maria C. Swartz, Kristofer Jennings, Elena Volpi

Cerebral infarction in advanced non-small cell lung cancer: a case control study

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Motoyasu Kato, Takehito Shukuya, Keita Mori, Ryota Kanemaru, Yuichiro Honma, Yuta Nanjo, Keiko Muraki, Rina Shibayama, Ryo Koyama, Naoko Shimada, Fumiyuki Takahashi, Kazuhisa Takahashi

Aggressive breast cancer in western Kenya has early onset, high proliferation, and immune cell infiltration

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Rispah T. Sawe, Maggie Kerper, Sunil Badve, Jun Li, Mayra Sandoval-Cooper, Jingmeng Xie, Zonggao Shi, Kirtika Patel, David Chumba, Ayub Ofulla, Jenifer Prosperi, Katherine Taylor, M. Sharon Stack, Simeon Mining, Laurie E. Littlepage

Dynamic modulation of phosphoprotein expression in ovarian cancer xenograft models

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Antonis Koussounadis, Simon P. Langdon, Inhwa Um, Charlene Kay, Kyle E. Francis, David J. Harrison, V. Anne Smith

Expression of F-actin-capping protein subunit beta, CAPZB, is associated with cell growth and motility in epithelioid sarcoma

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Kenta Mukaihara, Yoshiyuki Suehara, Shinji Kohsaka, Daisuke Kubota, Midori Toda-Ishii, Keisuke Akaike, Tsutomu Fujimura, Eisuke Kobayashi, Takashi Yao, Marc Ladanyi, Kazuo Kaneko, Tsuyoshi Saito

Role of autophagy-related protein expression in patients with rectal cancer treated with neoadjuvant chemoradiotherapy

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Byoung Yong Shim, Der Sheng Sun, Hye Sung Won, Myung Ah Lee, Soon Uk Hong, Ji-Han Jung, Hyeon-Min Cho, Yoon Ho Ko

Urgent surgery after emergency presentation for colorectal cancer has no impact on overall and disease-free survival: a propensity score analysis

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Benjamin Weixler, Rene Warschkow, Michaela Ramser, Raoul Droeser, Urs von Holzen, Daniel Oertli, Christoph Kettelhack

The effect of visceral obesity on clinicopathological features in patients with endometrial cancer: a retrospective analysis of 200 Chinese patients

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Shuang Ye, Hao Wen, Zhaoxia Jiang, Xiaohua Wu

Mutational status of synchronous and metachronous tumor samples in patients with metastatic non-small-cell lung cancer

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Gilles Quéré, Renaud Descourt, Gilles Robinet, Sandrine Autret, Odile Raguenes, Brigitte Fercot, Pierre Alemany, Arnaud Uguen, Claude Férec, Isabelle Quintin-Roué, Gérald Le Gac

A genetic variant of the NTCP gene is associated with HBV infection status in a Chinese population

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Jingmin Yang, Yuan Yang, Mingying Xia, Lianghui Wang, Weiping Zhou, Yajun Yang, Yueming Jiang, Hongyang Wang, Ji Qian, Li Jin, Xiaofeng Wang

Association between alcohol intake and the risk of pancreatic cancer: a dose–response meta-analysis of cohort studies

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Ye-Tao Wang, Ya-Wen Gou, Wen-Wen Jin, Mei Xiao, Hua-Ying Fang

Copy number of the Adenomatous Polyposis Coli gene is not always neutral in sporadic colorectal cancers with loss of heterozygosity for the gene

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Peter Zauber, Stephen Marotta, Marlene Sabbath-Solitare

Dynamic changes of alkaline phosphatase are strongly associated with PSA-decline and predict best clinical benefit earlier than PSA-changes under therapy with abiraterone acetate in bone metastatic castration resistant prostate cancer

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Phillip Mikah, Laura-Maria Krabbe, Okyaz Eminaga, Edwin Herrmann, Philipp Papavassilis, Reemt Hinkelammert, Axel Semjonow, Andres-Jan Schrader, Martin Boegemann

Relevance of miR-21 in regulation of tumor suppressor gene PTEN in human cervical cancer cells

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Oscar Peralta-Zaragoza, Jessica Deas, Angélica Meneses-Acosta, Faustino De la O-Gómez, Gloria Fernández-Tilapa, Claudia Gómez-Cerón, Odelia Benítez-Boijseauneau, Ana Burguete-García, Kirvis Torres-Poveda, Victor Hugo Bermúdez-Morales, Vicente Madrid-Marina, Mauricio Rodríguez-Dorantes, Alfredo Hidalgo-Miranda, Carlos Pérez-Plasencia

Evaluation of the role of remission status in a heterogeneous limited disease small-cell lung cancer patient cohort treated with definitive chemoradiotherapy

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Farkhad Manapov, Maximilian Niyazi, Sabine Gerum, Olarn Roengvoraphoj, Chukwuka Eze, Minglun Li, Guido Hildebrandt, Rainer Fietkau, Gunther Klautke, Claus Belka

Efficacy and safety of Vinflunine for advanced or metastatic urothelial carcinoma in routine practice based on the French multi-centre CURVE study

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Jacques Médioni, Mario Di Palma, Aline Guillot, Dominique Spaeth, Christine Théodore

MiR-29c regulates the expression of miR-34c and miR-449a by targeting DNA methyltransferase 3a and 3b in nasopharyngeal carcinoma

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Man Niu, Dan Gao, Qiuyuan Wen, Pingpin Wei, Suming Pan, Cijun Shuai, Huiling Ma, Juanjuan Xiang, Zheng Li, Songqing Fan, Guiyuan Li, Shuping Peng

Different Array CGH profiles within hereditary breast cancer tumors associated to BRCA1 expression and overall survival

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Carolina Alvarez, Andrés Aravena, Teresa Tapia, Ester Rozenblum, Luisa Solís, Alejandro Corvalán, Mauricio Camus, Manuel Alvarez, David Munroe, Alejandro Maass, Pilar Carvallo

Folic acid tagged nanoceria as a novel therapeutic agent in ovarian cancer

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Miriana Hijaz, Soumen Das, Ismail Mert, Ankur Gupta, Zaid Al-Wahab, Calvin Tebbe, Sajad Dar, Jasdeep Chhina, Shailendra Giri, Adnan Munkarah, Sudipta Seal, Ramandeep Rattan

Self-sampling in cervical cancer screening: comparison of a brush-based and a lavage-based cervicovaginal self-sampling device

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Liisa Karjalainen, Ahti Anttila, Pekka Nieminen, Tapio Luostarinen, Anni Virtanen

Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors

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Ko Sato, Satoshi Watanabe, Aya Ohtsubo, Satoshi Shoji, Daisuke Ishikawa, Tomohiro Tanaka, Koichiro Nozaki, Rie Kondo, Masaaki Okajima, Satoru Miura, Junta Tanaka, Takuro Sakagami, Toshiyuki Koya, Hiroshi Kagamu, Hirohisa Yoshizawa, Ichiei Narita

Elevated ratio of MMP2/MMP9 activity is associated with poor response to chemotherapy in osteosarcoma

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Pierre Kunz, Heiner Sähr, Burkhard Lehner, Christian Fischer, Elisabeth Seebach, Jörg Fellenberg

Correlation between EGFR gene mutation, cytologic tumor markers, 18F-FDG uptake in non-small cell lung cancer

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Arthur Cho, Jin Hur, Yong Wha Moon, Sae Rom Hong, Young Joo Suh, Yun Jung Kim, Dong Jin Im, Yoo Jin Hong, Hye-Jeong Lee, Young Jin Kim, Hyo Sup Shim, Jae Seok Lee, Joo-Hang Kim, Byoung Wook Choi

GFRA3 promoter methylation may be associated with decreased postoperative survival in gastric cancer

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Lars Lohne Eftang, Jovana Klajic, Vessela N. Kristensen, Jörg Tost, Qin Ying Esbensen, Gustav Peter Blom, Ida Rashida Khan Bukholm, Geir Bukholm

Epigenetic silencing of miR-181c by DNA methylation in glioblastoma cell lines

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Erandi Ayala-Ortega, Rodrigo Arzate-Mejía, Rosario Pérez-Molina, Edgar González-Buendía, Karin Meier, Georgina Guerrero, Félix Recillas-Targa

Epithelial cell adhesion molecule in human hepatocellular carcinoma cell lines: a target of chemoresistence

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Yan Li, Russell W. Farmer, Yingbin Yang, Robert C. G. Martin

Runs of homozygosity and inbreeding in thyroid cancer

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Hauke Thomsen, Bowang Chen, Gisella Figlioli, Rossella Elisei, Cristina Romei, Monica Cipollini, Alfonso Cristaudo, Franco Bambi, Per Hoffmann, Stefan Herms, Stefano Landi, Kari Hemminki, Federica Gemignani, Asta Försti

Nuclear expression of Lyn, a Src family kinase member, is associated with poor prognosis in renal cancer patients

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Antonia K. Roseweir, Tahir Qayyum, Zhi Lim, Rachel Hammond, Alasdair I. MacDonald, Sioban Fraser, Grenville M. Oades, Michael Aitchison, Robert J. Jones, Joanne Edwards

Clinical significance of the expression of autophagy-associated marker, beclin 1, in breast cancer patients who received neoadjuvant endocrine therapy

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Takayuki Ueno, Shigehira Saji, Masahiro Sugimoto, Norikazu Masuda, Katsumasa Kuroi, Nobuaki Sato, Hiroyuki Takei, Yutaka Yamamoto, Shinji Ohno, Hiroko Yamashita, Kazufumi Hisamatsu, Kenjiro Aogi, Hiroji Iwata, Shigeru Imoto, Hironobu Sasano, Masakazu Toi

Biochemical markers of bone turnover in patients with spinal metastases after resistance training under radiotherapy – a randomized trial

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Harald Rief, Georg Omlor, Michael Akbar, Thomas Bruckner, Stefan Rieken, Robert Förster, Ingmar Schlampp, Thomas Welzel, Tilman Bostel, Heinz Jürgen Roth, Jürgen Debus

Radical nephrectomy and regional lymph node dissection for locally advanced type 2 papillary renal cell carcinoma in an at-risk individual from a family with hereditary leiomyomatosis and renal cell cancer: a case report

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• Case report

Takao Kamai, Hideyuki Abe, Kyoko Arai, Satoshi Murakami, Setsu Sakamoto, Yasushi Kaji, Ken-Ichiro Yoshida

Herpes simplex virus-1 encephalitis induced by chemoradiotherapy and steroids in an esophageal cancer patient: a case report

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• Case report

Masaaki Saito, Hirokazu Kiyozaki, Tamotu Obitsu, Hirofumi Imoto, Yusuke Taniyama, Osamu Takata, Toshiki Rikiyama

Randomised controlled trial of a home-based physical activity intervention in breast cancer survivors

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Ian M. Lahart, George S. Metsios, Alan M. Nevill, George D. Kitas, Amtul R. Carmichael

Front-line intraperitoneal versus intravenous chemotherapy in stage III-IV epithelial ovarian, tubal, and peritoneal cancer with minimal residual disease: a competing risk analysis

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Yen-Hou Chang, Wai-Hou Li, Yi Chang, Chia-Wen Peng, Ching-Hsuan Cheng, Wei-Pin Chang, Chi-Mu Chuang

Snail-induced epithelial-to-mesenchymal transition of MCF-7 breast cancer cells: systems analysis of molecular changes and their effect on radiation and drug sensitivity

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Roman Mezencev, Lilya V. Matyunina, Neda Jabbari, John F. McDonald

Pursuing equity in cancer care: implementation, challenges and preliminary findings of a public cancer referral center in rural Rwanda

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Neo M. Tapela, Tharcisse Mpunga, Bethany Hedt-Gauthier, Molly Moore, Egide Mpanumusingo, Mary Jue Xu, Ignace Nzayisenga, Vedaste Hategekimana, Denis Gilbert Umuhizi, Lydia E. Pace, Jean Bosco Bigirimana, JingJing Wang, Caitlin Driscoll, Frank R. Uwizeye, Peter C. Drobac, Gedeon Ngoga, Cyprien Shyirambere, Clemence Muhayimana, Leslie Lehmann, Lawrence N. Shulman

RETRACTED ARTICLE: CDK4 and miR-15a comprise an abnormal automodulatory feedback loop stimulating the pathogenesis and inducing chemotherapy resistance in nasopharyngeal carcinoma

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Zhen Liu, Chao Cheng, Xiaojun Luo, Qiong Xia, Yejie Zhang, Xiaobing Long, Qingping Jiang, Weiyi Fang

Apoptosis-induced ectodomain shedding of hypoxia-regulated carbonic anhydrase IX from tumor cells: a double-edged response to chemotherapy

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Ivana Vidlickova, Franck Dequiedt, Lenka Jelenska, Olga Sedlakova, Michal Pastorek, Stanislav Stuchlik, Jaromir Pastorek, Miriam Zatovicova, Silvia Pastorekova

TNF-alpha promotes lymphangiogenesis and lymphatic metastasis of gallbladder cancer through the ERK1/2/AP-1/VEGF-D pathway

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HaiJie Hong, Lei Jiang, YanFei Lin, CaiLong He, GuangWei Zhu, Qiang Du, XiaoQian Wang, FeiFei She, YanLing Chen

Diagnostic values of serum cathepsin B and D in patients with nasopharyngeal carcinoma

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Gongjun Tan, Qianxu Liu, Xiaowei Tang, Ting Kang, Yuejin Li, Jinping Lu, Xiaoming Zhao, Faqing Tang

Hair dye use, regular exercise, and the risk and prognosis of prostate cancer: multicenter case–control and case-only studies

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Shu-Yu Tai, Hui-Min Hsieh, Shu-Pin Huang, Ming-Tsang Wu

Severe myositis of the hip flexors after pre-operative chemoradiation therapy for locally advanced rectal cancer: case report

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• Case report

Matthew M. Florczynski, Michael S. Sanatani, Lauren Mai, Barbara Fisher, Dwight E. Moulin, Jeffrey Cao, Alexander V. Louie, Janet E. Pope, Eric Leung

The prognostic value of rectal invasion for stage IVA uterine cervical cancer treated with radiation therapy

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Masaru Wakatsuki, Shingo Kato, Hiroki Kiyohara, Tatsuya Ohno, Kumiko Karasawa, Tomoaki Tamaki, Ken Ando, Shintaro Shiba, Tadashi Kamada, Takashi Nakano

Honokiol inhibits sphere formation and xenograft growth of oral cancer side population cells accompanied with JAK/STAT signaling pathway suppression and apoptosis induction

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Jhy-Shrian Huang, Chih-Jung Yao, Shuang-En Chuang, Chi-Tai Yeh, Liang-Ming Lee, Ruei-Ming Chen, Wan-Ju Chao, Jacqueline Whang-Peng, Gi-Ming Lai

The milk-derived fusion peptide, ACFP, suppresses the growth of primary human ovarian cancer cells by regulating apoptotic gene expression and signaling pathways

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Juan Zhou, Mengjing Zhao, Yigui Tang, Jing Wang, Cai Wei, Fang Gu, Ting Lei, Zhiwu Chen, Yide Qin

Oral proteasome inhibitor with strong preclinical efficacy in myeloma models

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Jonghoon Park, Eok Park, Cheol-Kyu Jung, Seung-Wan Kang, Byung Gyu Kim, Youngjoo Jung, Tae Hun Kim, Ji-Young Lim, Sung-Eun Lee, Chang-Ki Min, Kwang-Ai Won

Comparison of clinical outcomes between luminal invasive ductal carcinoma and luminal invasive lobular carcinoma

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Yayoi Adachi, Junko Ishiguro, Haruru Kotani, Tomoka Hisada, Mari Ichikawa, Naomi Gondo, Akiyo Yoshimura, Naoto Kondo, Masaya Hattori, Masataka Sawaki, Takashi Fujita, Toyone Kikumori, Yasushi Yatabe, Yasuhiro Kodera, Hiroji Iwata

The prognostic value of lactate dehydrogenase levels in colorectal cancer: a meta-analysis

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Guanghua Li, Zhao Wang, Jianbo Xu, Hui Wu, Shirong Cai, Yulong He

At least two well-spaced samples are needed to genotype a solid tumor

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Kimberly Siegmund, Darryl Shibata

Antitumor effects of cecropin B-LHRH’ on drug-resistant ovarian and endometrial cancer cells

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Xiaoyong Li, Bo Shen, Qi Chen, Xiaohui Zhang, Yiqing Ye, Fengmei Wang, Xinmei Zhang

Mmu-miR-125b overexpression suppresses NO production in activated macrophages by targeting eEF2K and CCNA2

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Zhenbiao Xu, Lianmei Zhao, Xin Yang, Sisi Ma, Yehua Ge, Yanxin Liu, Shilian Liu, Juan Shi, Dexian Zheng

Down-regulation of S100A9 inhibits osteosarcoma cell growth through inactivating MAPK and NF-κB signaling pathways

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Si Cheng, Xi Zhang, Ning Huang, Quanhe Qiu, Ying Jin, Dianming Jiang

Response to post-axitinib treatment in patients with metastatic renal cell carcinoma

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Namita Chittoria, Housam Haddad, Paul Elson, Nizar M. Tannir, Laura S. Wood, Robert Dreicer, Jorge A. Garcia, Brian I. Rini, Eric Jonasch

Cervical and breast cancer screening participation for women with chronic conditions in France: results from a national health survey

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Panayotis Constantinou, Rosemary Dray-Spira, Gwenn Menvielle

CYP1A2 – a novel genetic marker for early aromatase inhibitor response in the treatment of breast cancer patients

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Maria Simonsson, Srinivas Veerla, Andrea Markkula, Carsten Rose, Christian Ingvar, Helena Jernström

Nemo-like kinase as a negative regulator of nuclear receptor Nurr1 gene transcription in prostate cancer

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Jian Wang, Zhi-Hong Yang, Hua Chen, Hua-Hui Li, Li-Yong Chen, Zhu Zhu, Ying Zou, Cong-Cong Ding, Jing Yang, Zhi-Wei He

What surgeons tell patients and what patients want to know before major cancer surgery: a qualitative study

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Angus G. K. McNair, F MacKichan, J. L. Donovan, S. T. Brookes, K. N. L. Avery, S. M. Griffin, T. Crosby, J. M. Blazeby

Planar cell polarity gene expression correlates with tumor cell viability and prognostic outcome in neuroblastoma

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Cecilia Dyberg, Panagiotis Papachristou, Bjørn Helge Haug, Hugo Lagercrantz, Per Kogner, Thomas Ringstedt, Malin Wickström, John Inge Johnsen

Systematic review: brain metastases from colorectal cancer—Incidence and patient characteristics

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Troels Dreier Christensen, Karen-Lise Garm Spindler, Jesper Andreas Palshof, Dorte Lisbet Nielsen

Verification of microRNA expression in human endometrial adenocarcinoma

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Sanja Jurcevic, Karin Klinga-Levan, Björn Olsson, Katarina Ejeskär

Benchmarking trial between France and Australia comparing management of primary rectal cancer beyond TME and locally recurrent rectal cancer (PelviCare Trial): rationale and design

• Open Access
• Study protocol

Quentin Denost, Florence Saillour, Lindy Masya, Helene Maillou Martinaud, Stephanie Guillon, Marion Kret, Eric Rullier, Bruno Quintard, Michael Solomon

In vitro and in vivo activity of melflufen (J1) in lymphoma

• Open Access
• Research article

Maryam Delforoush, Sara Strese, Malin Wickström, Rolf Larsson, Gunilla Enblad, Joachim Gullbo

Advance care planning – a multi-centre cluster randomised clinical trial: the research protocol of the ACTION study

• Open Access
• Study protocol

Judith A. C. Rietjens, Ida J. Korfage, Lesley Dunleavy, Nancy J. Preston, Lea J. Jabbarian, Caroline Arnfeldt Christensen, Maja de Brito, Francesco Bulli, Glenys Caswell, Branka Červ, Johannes van Delden, Luc Deliens, Giuseppe Gorini, Mogens Groenvold, Dirk Houttekier, Francesca Ingravallo, Marijke C. Kars, Urška Lunder, Guido Miccinesi, Alenka Mimić, Eugenio Paci, Sheila Payne, Suzanne Polinder, Kristian Pollock, Jane Seymour, Anja Simonič, Anna Thit Johnsen, Mariëtte N. Verkissen, Esther de Vries, Andrew Wilcock, Marieke Zwakman, Agnes van der Heide (Pl)

Randomized phase III trial of amrubicin/cisplatin versus etoposide/cisplatin as first-line treatment for extensive small-cell lung cancer

• Open Access
• Research article

Yan Sun, Ying Cheng, Xuezhi Hao, Jie Wang, Chengping Hu, Baohui Han, Xiaoqing Liu, Li Zhang, Huiping Wan, Zhongjun Xia, Yunpeng Liu, Wei Li, Mei Hou, Helong Zhang, Qingyu Xiu, Yunzhong Zhu, Jifeng Feng, Shukui Qin, Xiaoyan Luo

A phase II study of Endostatin in combination with paclitaxel, carboplatin, and radiotherapy in patients with unresectable locally advanced non-small cell lung cancer

• Open Access
• Research article

Xiao-Jiang Sun, Qing-Hua Deng, Xin-Min Yu, Yong-Lin Ji, Yuan-Da Zheng, Hao Jiang, Ya-Ping Xu, Sheng-Lin Ma

Minimal renal toxicity after Rituximab DHAP with a modified cisplatin application scheme in patients with relapsed or refractory diffuse large B-cell lymphoma

• Open Access
• Research article

K. Lisenko, F. McClanahan, T. Schöning, M. A. Schwarzbich, M. Cremer, T. Dittrich, A. D. Ho, M. Witzens-Harig

Establishment and characterization of new cell lines of anaplastic pancreatic cancer, which is a rare malignancy: OCUP-A1 and OCUP-A2

• Open Access
• Research article

Kotaro Miura, Kenjiro Kimura, Ryosuke Amano, Sadaaki Yamazoe, Go Ohira, Akihiro Murata, Kohei Nishio, Tsuyoshi Hasegawa, Masakazu Yashiro, Bunzo Nakata, Masaichi Ohira, Kosei Hirakawa

Prognostic impact of IKZF1 deletion in adults with common B-cell acute lymphoblastic leukemia

• Open Access
• Research article

Qiu-Mei Yao, Kai-Yan Liu, Robert Peter Gale, Bin Jiang, Yan-Rong Liu, Qian Jiang, Hao Jiang, Xiao-Hui Zhang, Mei-Jie Zhang, Shan-Shan Chen, Xiao-Jun Huang, Lan-Ping Xu, Guo-Rui Ruan

Treatment with anti-IL-6 receptor antibody prevented increase in serum hepcidin levels and improved anemia in mice inoculated with IL-6–producing lung carcinoma cells

• Open Access
• Research article

Mariko Noguchi-Sasaki, Yusuke Sasaki, Yasushi Shimonaka, Kazushige Mori, Kaori Fujimoto-Ouchi

Comparative analysis of copy number variations in ulcerative colitis associated and sporadic colorectal neoplasia

• Open Access
• Research article

B. M. Shivakumar, Sanjiban Chakrabarty, Harish Rotti, Venu Seenappa, Lakshmi Rao, Vasudevan Geetha, B. V. Tantry, Hema Kini, Rajesh Dharamsi, C. Ganesh Pai, Kapaettu Satyamoorthy

Erratum to: Correlation between S-1 treatment outcome and expression of biomarkers for refractory thymic carcinoma

• Open Access
• Erratum

Yusuke Okuma, Yukio Hosomi, Shingo Miyamoto, Masahiko Shibuya, Tatsuru Okamura, Tsunekazu Hishima

Short-term culture of tumour slices reveals the heterogeneous sensitivity of human head and neck squamous cell carcinoma to targeted therapies

• Open Access
• Research article

Jérôme Donnadieu, Emma Lachaier, Marine Peria, Zuzana Saidak, Stéphanie Dakpe, Jean-Fortune Ikoli, Bruno Chauffert, Cyril Page, Antoine Galmiche

Identification of stromal ColXα1 and tumor-infiltrating lymphocytes as putative predictive markers of neoadjuvant therapy in estrogen receptor-positive/HER2-positive breast cancer

• Open Access
• Research article

Alexander S. Brodsky, Jinjun Xiong, Dongfang Yang, Christoph Schorl, Mary Anne Fenton, Theresa A. Graves, William M. Sikov, Murray B. Resnick, Yihong Wang

Erratum to: Generation of an algorithm based on minimal gene sets to clinically subtype triple negative breast cancer patients

• Open Access
• Erratum

Brian Z. Ring, David R. Hout, Stephan W. Morris, Kasey Lawrence, Brock L. Schweitzer, Daniel B. Bailey, Brian D. Lehmann, Jennifer A. Pietenpol, Robert S. Seitz

Survivin protein expression is involved in the progression of non-small cell lung cancer in Asians: a meta-analysis

• Open Access
• Research article

Liang Duan, Xuefei Hu, Yuxing Jin, Ruijun Liu, Qingjun You

Improvement of ablative margins by the intraoperative use of CEUS-CT/MR image fusion in hepatocellular carcinoma

• Open Access
• Research article

Kai Li, Zhong-Zhen Su, Er-Jiao Xu, Jin-Xiu Ju, Xiao-Chun Meng, Rong-Qin Zheng

A phase Ia/Ib clinical trial of metronomic chemotherapy based on a mathematical model of oral vinorelbine in metastatic non-small cell lung cancer and malignant pleural mesothelioma: rationale and study protocol

• Open Access
• Study protocol

Xavier Elharrar, Dominique Barbolosi, Joseph Ciccolini, Christophe Meille, Christian Faivre, Bruno Lacarelle, Nicolas André, Fabrice Barlesi

Selective activation of TNFR1 and NF-κB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells

• Open Access
• Research article

Christiana G. Savva, Sotirios Totokotsopoulos, Kyriakos C. Nicolaou, Christiana M. Neophytou, Andreas I. Constantinou

Gemcitabine and docetaxel in relapsed and unresectable high-grade osteosarcoma and spindle cell sarcoma of bone

• Open Access
• Research article

E. Palmerini, R. L. Jones, E. Marchesi, A. Paioli, M. Cesari, A. Longhi, C. Meazza, L. Coccoli, F. Fagioli, S. Asaftei, G. Grignani, A. Tamburini, S. M. Pollack, P. Picci, S. Ferrari

The Lung Screen Uptake Trial (LSUT): protocol for a randomised controlled demonstration lung cancer screening pilot testing a targeted invitation strategy for high risk and ‘hard-to-reach’ patients

• Open Access
• Study protocol

Samantha L. Quaife, Mamta Ruparel, Rebecca J. Beeken, Andy McEwen, John Isitt, Gary Nolan, Karen Sennett, David R. Baldwin, Stephen W. Duffy, Samuel M. Janes, Jane Wardle

High-dose chemotherapy and autologous stem cell transplant compared with conventional chemotherapy for consolidation in newly diagnosed primary CNS lymphoma—a randomized phase III trial (MATRix)

• Open Access
• Study protocol

Elisabeth Schorb, Juergen Finke, Andrés J. M. Ferreri, Gabriele Ihorst, Kristina Mikesch, Benjamin Kasenda, Kristina Fritsch, Heidi Fricker, Elvira Burger, Olga Grishina, Elke Valk, Emanuele Zucca, Gerald Illerhaus

Alcohol-related breast cancer in postmenopausal women – effect of CYP19A1, PPARG and PPARGC1A polymorphisms on female sex-hormone levels and interaction with alcohol consumption and NSAID usage in a nested case-control study and a randomised controlled trial

• Open Access
• Research article

Tine Iskov Kopp, Ditte Marie Jensen, Gitte Ravn-Haren, Arieh Cohen, Helle Molgaard Sommer, Lars Ove Dragsted, Anne Tjonneland, David Michael Hougaard, Ulla Vogel

Cancer incidence in urban Shanghai, 1973-2010: an updated trend and age-period-cohort effects

• Open Access
• Research article

Ping-Ping Bao, Ying Zheng, Chun-Xiao Wu, Zhe-Zhou Huang, Yu-Tang Gao, Fan Jin, Yong-Bing Xiang, Wei-Jian Zhong, Wei Lu, Fan Wu

Relevance of internal time and circadian robustness for cancer patients

• Open Access
• Research article

Elisabet Ortiz-Tudela, Pasquale F. Innominato, Maria Angeles Rol, Francis Lévi, Juan Antonio Madrid

Basal metabolic state governs AIF-dependent growth support in pancreatic cancer cells

• Open Access
• Research article

Andrew J. Scott, Amanda S. Wilkinson, John C. Wilkinson

Chemotherapy for intracranial ependymoma in adults

• Open Access
• Research article

Dorothee Gramatzki, Patrick Roth, Jörg Felsberg, Silvia Hofer, Elisabeth J. Rushing, Bettina Hentschel, Manfred Westphal, Dietmar Krex, Matthias Simon, Oliver Schnell, Wolfgang Wick, Guido Reifenberger, Michael Weller

Accelerated hypofractionated three-dimensional conformal radiation therapy (3 Gy/fraction) combined with concurrent chemotherapy for patients with unresectable stage III non-small cell lung cancer: preliminary results of an early terminated phase II trial

• Open Access
• Research article

Xiao-Cang Ren, Quan-Yu Wang, Rui Zhang, Xue-Ji Chen, Na Wang, Yue-E Liu, Jie Zong, Zhi-Jun Guo, Dong-Ying Wang, Qiang Lin

Lung cancer treatment and mortality for Aboriginal people in New South Wales, Australia: results from a population-based record linkage study and medical record audit

• Open Access
• Research article

Alison Gibberd, Rajah Supramaniam, Anthony Dillon, Bruce K. Armstrong, Dianne L. O’Connell

Rationale and design of the German-Speaking Myeloma Multicenter Group (GMMG) trial ReLApsE: a randomized, open, multicenter phase III trial of lenalidomide/dexamethasone versus lenalidomide/dexamethasone plus subsequent autologous stem cell transplantation and lenalidomide maintenance in patients with relapsed multiple myeloma

• Open Access
• Study protocol

Marc-Andrea Baertsch, Jana Schlenzka, Elias K. Mai, Maximilian Merz, Jens Hillengaß, Marc S. Raab, Dirk Hose, Patrick Wuchter, Anthony D. Ho, Anna Jauch, Thomas Hielscher, Christina Kunz, Steffen Luntz, Stefan Klein, Ingo G. H. Schmidt-Wolf, Martin Goerner, Martin Schmidt-Hieber, Peter Reimer, Ullrich Graeven, Roland Fenk, Hans Salwender, Christof Scheid, Axel Nogai, Mathias Haenel, Hans W. Lindemann, Hans Martin, Richard Noppeney, Katja Weisel, Hartmut Goldschmidt

Protocol of a randomized controlled trial of the fear of recurrence therapy (FORT) intervention for women with breast or gynecological cancer

• Open Access
• Study protocol

Christine Maheu, Sophie Lebel, Christine Courbasson, Monique Lefebvre, Mina Singh, Lori J. Bernstein, Linda Muraca, Aronela Benea, Lynne Jolicoeur, Cheryl Harris, Agnihotram V. Ramanakumar, Sarah Ferguson, Souraya Sidani

A predictive tool particularly designed for elderly myeloma patients presenting with spinal cord compression

• Open Access
• Research article

Dirk Rades, Antonio Jose Conde-Moreno, Jon Cacicedo, Theo Veninga, Niklas Gebauer, Tobias Bartscht, Steven E. Schild

Risks of developing breast and colorectal cancer in association with incomes and geographic locations in Texas: a retrospective cohort study

• Open Access
• Research article

Zheyu Liu, Kai Zhang, Xianglin L. Du

The occurrence of non-melanoma malignant skin lesions and non-cutaneous squamous-cell carcinoma among metastatic melanoma patients: an observational cohort study in Denmark

• Open Access
• Research article

Haojie Li, Lars Pedersen, Mette Nørgaard, Sinna P. Ulrichsen, Sandra K. Thygesen, Jeanenne J. Nelson

After low and high dose-rate interstitial brachytherapy followed by IMRT radiotherapy for intermediate and high risk prostate cancer

• Open Access
• Research article

Satoshi Nakamura, Naoya Murakami, Koji Inaba, Akihisa Wakita, Kazuma Kobayashi, Kana Takahashi, Hiroyuki Okamoto, Rei Umezawa, Madoka Morota, Minako Sumi, Hiroshi Igaki, Yoshinori Ito, Jun Itami

Expression of the cereblon binding protein argonaute 2 plays an important role for multiple myeloma cell growth and survival

• Open Access
• Research article

Qinqin Xu, Yue-xian Hou, Paul Langlais, Patrick Erickson, James Zhu, Chang-Xin Shi, Moulun Luo, Yuanxiao Zhu, Ye Xu, Lawrence J. Mandarino, Keith Stewart, Xiu-bao Chang

Genetic polymorphism rs3760396 of the chemokine (C-C motif) ligand 2 gene (CCL2) associated with the susceptibility of lung cancer in a pathological subtype-specific manner in Han-ancestry Chinese: a case control study

• Open Access
• Research article

Xu Li, Fangcai Lin, Hong Zhou

Focal vs extended ablation in localized prostate cancer with irreversible electroporation; a multi-center randomized controlled trial

• Open Access
• Study protocol

Matthijs J. V. Scheltema, Willemien van den Bos, Daniel M. de Bruin, Hessel Wijkstra, M. Pilar Laguna, Theo M. de Reijke, Jean JMCH de la Rosette

A cell transportation solution that preserves live circulating tumor cells in patient blood samples

• Open Access
• Technical advance

Steingrimur Stefansson, Daniel L. Adams, William B. Ershler, Huyen Le, David H. Ho

Follow-up practices for high-grade extremity Osteosarcoma

• Open Access
• Research article

Christian Rothermundt, Beatrice M. Seddon, Palma Dileo, Sandra J. Strauss, Joanne Coleman, Timothy W. Briggs, Sarah R. Haile, Jeremy S. Whelan

MEK5 overexpression is associated with the occurrence and development of colorectal cancer

• Open Access
• Research article

Dechang Diao, Lei Wang, Jin Wan, Zhiqiang Chen, Junsheng Peng, Huanliang Liu, Xinlin Chen, Wei Wang, Liaonan Zou

Design of a multicentre randomized controlled trial to evaluate the effectiveness of a tailored clinical support intervention to enhance return to work for gastrointestinal cancer patients

• Open Access
• Study protocol

AnneClaire G.N.M. Zaman, Kristien M.A.J. Tytgat, Jean H.G. Klinkenbijl, Monique H.W. Frings-Dresen, Angela G.E.M. de Boer

Profound reduction in tamoxifen active metabolite endoxifen in a breast cancer patient treated with rifampin prior to initiation of an anti-TNFα biologic for ulcerative colitis: a case report

• Open Access
• Case report

Sara L. Henderson, Wendy A. Teft, Richard B. Kim

Enhancement of the CXCL12/CXCR4 axis due to acquisition of gemcitabine resistance in pancreatic cancer: effect of CXCR4 antagonists

• Open Access
• Research article

Mamoru Morimoto, Yoichi Matsuo, Shuji Koide, Ken Tsuboi, Tomoya Shamoto, Takafumi Sato, Kenta Saito, Hiroki Takahashi, Hiromitsu Takeyama

Feasibility study of first-line chemotherapy using Pemetrexed and Bevacizumab for advanced or recurrent nonsquamous non-small cell lung cancer in elderly patients: TORG1015

• Open Access
• Research article

Toshiyuki Kozuki, Naoyuki Nogami, Hiromoto Kitajima, Shunichiro Iwasawa, Emiko Sakaida, Yuichi Takiguchi, Satoshi Ikeda, Masahiro Yoshida, Terufumi Kato, Shingo Miyamoto, Kentaro Sakamaki, Tetsu Shinkai, Koshiro Watanabe

Evaluation of clinical parameters influencing the development of bone metastasis in breast cancer

• Open Access
• Research article

Joachim Diessner, Manfred Wischnewsky, Tanja Stüber, Roland Stein, Mathias Krockenberger, Sebastian Häusler, Wolfgang Janni, Rolf Kreienberg, Maria Blettner, Lukas Schwentner, Achim Wöckel, Catharina Bartmann

Tyrosine kinase inhibitor SU11274 increased tumorigenicity and enriched for melanoma-initiating cells by bioenergetic modulation

• Open Access
• Research article

Lucia Kucerova, Lucia Demkova, Svetlana Skolekova, Roman Bohovic, Miroslava Matuskova

Heme oxygenase is not involved in the anti-proliferative effects of statins on pancreatic cancer cells

• Open Access
• Research article

K. Vanova, S. Boukalova, H. Gbelcova, L. Muchova, J. Neuzil, R. Gurlich, T. Ruml, L. Vitek

Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet

• Open Access
• Research article

Danielle M. Lussier, Eric C. Woolf, John L. Johnson, Kenneth S. Brooks, Joseph N. Blattman, Adrienne C. Scheck

Smoking-related cancer in military veterans: retrospective cohort study of 57,000 veterans and 173,000 matched non-veterans

• Open Access
• Research article

Beverly P. Bergman, Daniel F. Mackay, David Morrison, Jill P. Pell

Combinatory effect of BRCA1 and HERC2 expression on outcome in advanced non-small-cell lung cancer

• Open Access
• Research article

Laura Bonanno, Carlota Costa, Margarita Majem, Jose-Javier Sanchez, Ignacio Rodriguez, Ana Gimenez-Capitan, Miquel Angel Molina-Vila, Alain Vergnenegre, Bartomeu Massuti, Adolfo Favaretto, Massimo Rugge, Cinta Pallares, Miquel Taron, Rafael Rosell

Decreased expression of hyaluronan synthase 1 and 2 associates with poor prognosis in cutaneous melanoma

• Open Access
• Research article

Mari Poukka, Andrey Bykachev, Hanna Siiskonen, Kristiina Tyynelä-Korhonen, Päivi Auvinen, Sanna Pasonen-Seppänen, Reijo Sironen

The non-genomic loss of function of tumor suppressors: an essential role in the pathogenesis of chronic myeloid leukemia chronic phase

• Open Access
• Review

Sabrina Crivellaro, Giovanna Carrà, Cristina Panuzzo, Riccardo Taulli, Angelo Guerrasio, Giuseppe Saglio, Alessandro Morotti

MicroRNA-663a is downregulated in non-small cell lung cancer and inhibits proliferation and invasion by targeting JunD

• Open Access
• Research article

Yi Zhang, Xiaoman Xu, Meng Zhang, Xin Wang, Xue Bai, Hui Li, Liang Kan, Yong Zhou, Huiyan Niu, Ping He

Epigenetically maintained SW13+ and SW13- subtypes have different oncogenic potential and convert with HDAC1 inhibition

• Open Access
• Research article

McKale R. Davis, Juliane J. Daggett, Agnes S. Pascual, Jessica M. Lam, Kathryn J. Leyva, Kimbal E. Cooper, Elizabeth E. Hull

Protein expression changes induced in a malignant melanoma cell line by the curcumin analogue compound D6

• Open Access
• Research article

Marina Pisano, Antonio Palomba, Alessandro Tanca, Daniela Pagnozzi, Sergio Uzzau, Maria Filippa Addis, Maria Antonietta Dettori, Davide Fabbri, Giuseppe Palmieri, Carla Rozzo

Preoperative chemoradiation with paclitaxel-carboplatin or with fluorouracil-oxaliplatin—folinic acid (FOLFOX) for resectable esophageal and junctional cancer: the PROTECT-1402, randomized phase 2 trial

• Open Access
• Study protocol

Mathieu Messager, Xavier Mirabel, Emmanuelle Tresch, Amaury Paumier, Véronique Vendrely, Laetitia Dahan, Olivier Glehen, Frederique Vasseur, Thomas Lacornerie, Guillaume Piessen, Farid El Hajbi, William B. Robb, Stéphanie Clisant, Andrew Kramar, Christophe Mariette, Antoine Adenis

The role of the addition of ovarian suppression to tamoxifen in young women with hormone-sensitive breast cancer who remain premenopausal or regain menstruation after chemotherapy (ASTRRA): study protocol for a randomized controlled trial and progress

• Open Access
• Study protocol

Hyun-Ah Kim, Sei Hyun Ahn, Seok Jin Nam, Seho Park, Jungsil Ro, Seock-Ah Im, Yong Sik Jung, Jung Han Yoon, Min Hee Hur, Yoon Ji Choi, Soo-Jung Lee, Joon Jeong, Se-Heon Cho, Sung Yong Kim, Min Hyuk Lee, Lee Su Kim, Byung-In Moon, Tae Hyun Kim, Chanheun Park, Sei Joong Kim, Sung Hoo Jung, Heungkyu Park, Geum Hee Gwak, Sun Hee Kang, Jong Gin Kim, Jeryong Kim, Su Yun Choi, Cheol-Wan Lim, Doyil Kim, Youngbum Yoo, Young-Jin Song, Yoon-Jung Kang, Sang Seol Jung, Hyuk Jai Shin, Kwan Ju Lee, Se-Hwan Han, Eun Sook Lee, Wonshik Han, Hee-Jung Kim, Woo Chul Noh

Pretreatment neutrophil-to-lymphocyte ratio is correlated with response to neoadjuvant chemotherapy as an independent prognostic indicator in breast cancer patients: a retrospective study

• Open Access
• Research article

Yi Chen, Kai Chen, Xiaoyun Xiao, Yan Nie, Shaohua Qu, Chang Gong, Fengxi Su, Erwei Song

Helicobacter pylori promotes angiogenesis depending on Wnt/beta-catenin-mediated vascular endothelial growth factor via the cyclooxygenase-2 pathway in gastric cancer

• Open Access
• Research article

Ningning Liu, Ning Zhou, Ni Chai, Xuan Liu, Haili Jiang, Qiong Wu, Qi Li

Influence of mTOR-inhibitors and mycophenolic acid on human cholangiocellular carcinoma and cancer associated fibroblasts

• Open Access
• Research article

Nils Heits, Tillmann Heinze, Alexander Bernsmeier, Jannik Kerber, Charlotte Hauser, Thomas Becker, Holger Kalthoff, Jan-Hendrik Egberts, Felix Braun

Continuous intraoperative monitoring of pelvic autonomic nerves during TME to prevent urogenital and anorectal dysfunction in rectal cancer patients (NEUROS): a randomized controlled trial

• Open Access
• Study protocol

D. W. Kauff, K Kronfeld, S Gorbulev, D Wachtlin, H Lang, W Kneist

An uncommon manifestation of paraneoplastic cerebellar degeneration in a patient with high grade urothelial, carcinoma with squamous differentiation: A case report and literature review

• Open Access
• Case report

Yaofeng Zhu, Shouzhen Chen, Songyu Chen, Jing Song, Fan Chen, Hu Guo, Zhenhua Shang, Yong Wang, Changkuo Zhou, Benkang Shi

Transarterial chemoembolization of hepatocellular carcinoma in a rat model: the effect of additional injection of survivin siRNA to the treatment protocol

• Open Access
• Research article

Thomas J. Vogl, Elsie Oppermann, Jun Qian, Ulli Imlau, Andreas Tran, Yousef Hamidavi, Huedayi Korkusuz, Wolf Otto Bechstein, Nour-Eldin Abdel-Rehim Nour-Eldin, Tatjana Gruber-Rouh, Renate Hammerstingl, Nagy Naguib Naeem Naguib

Progesterone receptor blockade in human breast cancer cells decreases cell cycle progression through G2/M by repressing G2/M genes

• Open Access
• Research article

Susan E. Clare, Akash Gupta, MiRan Choi, Manish Ranjan, Oukseub Lee, Jun Wang, David Z. Ivancic, J. Julie Kim, Seema A. Khan

Primary tumor site is a useful predictor of cetuximab efficacy in the third-line or salvage treatment of KRAS wild-type (exon 2 non-mutant) metastatic colorectal cancer: a nationwide cohort study

• Open Access
• Research article

Kuo-Hsing Chen, Yu-Yun Shao, Ho-Min Chen, Yu-Lin Lin, Zhong-Zhe Lin, Mei-Shu Lai, Ann-Lii Cheng, Kun-Huei Yeh

Activated thrombin-activatable fibrinolysis inhibitor (TAFIa) attenuates breast cancer cell metastatic behaviors through inhibition of plasminogen activation and extracellular proteolysis

• Open Access
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Zainab A. Bazzi, Danielle Lanoue, Mouhanned El-Youssef, Rocco Romagnuolo, Janice Tubman, Dora Cavallo-Medved, Lisa A. Porter, Michael B. Boffa

Platelet to lymphocyte ratio as an independent prognostic indicator for prostate cancer patients receiving androgen deprivation therapy

• Open Access
• Research article

Yanqing Wang, Fan Xu, Jiahua Pan, Yinjie Zhu, Xiaoguang Shao, Jianjun Sha, Zezhou Wang, Yong Cai, Qiang Liu, Baijun Dong, Wei Xue, Yiran Huang

Risk allelic load in Th2 and Th3 cytokines genes as biomarker of susceptibility to HPV-16 positive cervical cancer: a case control study

• Open Access
• Research article

K. Torres-Poveda, A. I. Burguete-García, M. Bahena-Román, R. Méndez-Martínez, M. A. Zurita-Díaz, G. López-Estrada, K. Delgado-Romero, O. Peralta-Zaragoza, V. H. Bermúdez-Morales, D. Cantú, A. García-Carrancá, V. Madrid-Marina

The effect of soluble E-selectin on tumor progression and metastasis

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Shin-Ae Kang, Celine A. Blache, Sandra Bajana, Nafis Hasan, Mohamed Kamal, Yoshihiro Morita, Vineet Gupta, Bilegtsaikhan Tsolmon, K. Stephen Suh, David G. Gorenstein, Wajeeha Razaq, Hallgeir Rui, Takemi Tanaka

Corepressive function of nuclear receptor coactivator 2 in androgen receptor of prostate cancer cells treated with antiandrogen

• Open Access
• Research article

Keisuke Takeda, Noboru Hara, Tsutomu Nishiyama, Masayuki Tasaki, Fumio Ishizaki, Yoshihiko Tomita

Characterisation of the DNA sequence specificity, cellular toxicity and cross-linking properties of novel bispyridine-based dinuclear platinum complexes

• Open Access
• Research article

Ben W. Johnson, Vincent Murray, Mark D. Temple

Importance of hereditary and selected environmental risk factors in the etiology of inflammatory breast cancer: a case-comparison study

• Open Access
• Research article

Roxana Moslehi, Elizabeth Freedman, Nur Zeinomar, Carmela Veneroso, Paul H. Levine

Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor

• Open Access
• Research article

Sarah Daakour, Leon Juvenal Hajingabo, Despoina Kerselidou, Aurelie Devresse, Richard Kettmann, Nicolas Simonis, Franck Dequiedt, Jean-Claude Twizere

Selective mode of action of plumbagin through BRCA1 deficient breast cancer stem cells

• Open Access
• Research article

Veena Somasundaram, Sreelatha K Hemalatha, Krishnendu Pal, Sutapa Sinha, Asha S. Nair, Debabrata Mukhopadhyay, Priya Srinivas

SLCO1B1*5 polymorphism (rs4149056) is associated with chemotherapy-induced amenorrhea in premenopausal women with breast cancer: a prospective cohort study

• Open Access
• Research article

Toralf Reimer, Sarah Kempert, Bernd Gerber, Hans-Jürgen Thiesen, Steffi Hartmann, Dirk Koczan

Potential efficacy of therapies targeting intrahepatic lesions after sorafenib treatment of patients with hepatocellular carcinoma

• Open Access
• Research article

Takeshi Terashima, Tatsuya Yamashita, Rika Horii, Kuniaki Arai, Kazunori Kawaguchi, Kazuya Kitamura, Taro Yamashita, Yoshio Sakai, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko

ICECREAM: randomised phase II study of cetuximab alone or in combination with irinotecan in patients with metastatic colorectal cancer with either KRAS, NRAS, BRAF and PI3KCA wild type, or G13D mutated tumours

• Open Access
• Study protocol

Eva Segelov, Paul Waring, Jayesh Desai, Kate Wilson, Val Gebski, Subotheni Thavaneswaran, Elena Elez, Craig Underhill, Nick Pavlakis, Lorraine Chantrill, Louise Nott, Michael Jefford, Mustafa Khasraw, Fiona Day, Harpreet Wasan, Fortunato Ciardiello, Chris Karapetis, Warren Joubert, Guy van Hazel, Andrew Haydon, Tim Price, Sabine Tejpar, Niall Tebbutt, Jeremy Shapiro

Assessment of laparoscopic stomach preserving surgery with sentinel basin dissection versus standard gastrectomy with lymphadenectomy in early gastric cancer–A multicenter randomized phase III clinical trial (SENORITA trial) protocol

• Open Access
• Study protocol

Ji Yeon Park, Young-Woo Kim, Keun Won Ryu, Byung-Ho Nam, Young Joon Lee, Sang Ho Jeong, Ji-Ho Park, Hoon Hur, Sang-Uk Han, Jae Seok Min, Ji Yeong An, Woo Jin Hyung, Gyu Seok Cho, Gui Ae Jeong, Oh Jeong, Young Kyu Park, Mi Ran Jung, Hong Man Yoon, Bang Wool Eom

Cross-talk between the Tissue Factor/coagulation factor VIIa complex and the tyrosine kinase receptor EphA2 in cancer

• Open Access
• Research article

Oskar Eriksson, Åsa Thulin, Anna Asplund, Geeta Hegde, Sanjay Navani, Agneta Siegbahn

Absence of an association of human polyomavirus and papillomavirus infection with lung cancer in China: a nested case–control study

• Open Access
• Research article

Danny V. Colombara, Lisa E. Manhart, Joseph J. Carter, Stephen E. Hawes, Noel S. Weiss, James P. Hughes, You-Lin Qiao, Philip R. Taylor, Jennifer S. Smith, Denise A. Galloway

L-Arginine supplementation inhibits the growth of breast cancer by enhancing innate and adaptive immune responses mediated by suppression of MDSCs in vivo

• Open Access
• Research article

Yu Cao, Yonghui Feng, Yanjun Zhang, Xiaotong Zhu, Feng Jin

Economic evaluation of the breast cancer screening programme in the Basque Country: retrospective cost-effectiveness and budget impact analysis

• Open Access
• Research article

Arantzazu Arrospide, Montserrat Rue, Nicolien T. van Ravesteyn, Merce Comas, Myriam Soto-Gordoa, Garbiñe Sarriugarte, Javier Mar

3D culture of Her2+ breast cancer cells promotes AKT to MAPK switching and a loss of therapeutic response

• Open Access
• Research article

Sharath Gangadhara, Chris Smith, Peter Barrett-Lee, Stephen Hiscox

Ultrasound screening for cholangiocarcinoma could detect premalignant lesions and early-stage diseases with survival benefits: a population-based prospective study of 4,225 subjects in an endemic area

• Open Access
• Research article

Prakongboon Sungkasubun, Surachate Siripongsakun, Kunlayanee Akkarachinorate, Sirachat Vidhyarkorn, Akeanong Worakitsitisatorn, Thaniya Sricharunrat, Sutida Singharuksa, Rawisak Chanwat, Chairat Bunchaliew, Sirima Charoenphattharaphesat, Ruechuta Molek, Maneenop Yimyaem, Gaidganok Sornsamdang, Kamonwan Soonklang, Kasiruck Wittayasak, Chirayu U. Auewarakul, Chulabhorn Mahidol

Clinical characteristics and prognosis of 272 postterm choriocarcinoma patients at Peking Union Medical College Hospital: a retrospective cohort study

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Jie Li, Junjun Yang, Pengfei Liu, Tong Ren, Jun Zhao, Fengzhi Feng, Xirun Wan, Yang Xiang

Long-term outcomes in radically treated synchronous vs. metachronous oligometastatic non-small-cell lung cancer

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Jochen Fleckenstein, Alev Petroff, Hans-Joachim Schäfers, Thomas Wehler, Jakob Schöpe, Christian Rübe

Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice

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J. R. Hens, I. Sinha, F. Perodin, T. Cooper, R. Sinha, J. Plummer, C. E. Perrone, D. Orentreich

High-risk oral leukoplakia is associated with aberrant promoter methylation of multiple genes

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Masanobu Abe, Satoshi Yamashita, Yoshiyuki Mori, Takahiro Abe, Hideto Saijo, Kazuto Hoshi, Toshikazu Ushijima, Tsuyoshi Takato

Prediction of non-muscle invasive bladder cancer outcomes assessed by innovative multimarker prognostic models

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E. López de Maturana, A. Picornell, A. Masson-Lecomte, M. Kogevinas, M. Márquez, A. Carrato, A. Tardón, J. Lloreta, M. García-Closas, D. Silverman, N. Rothman, S. Chanock, F. X. Real, M. E. Goddard, N. Malats

HERMIONE: a randomized Phase 2 trial of MM-302 plus trastuzumab versus chemotherapy of physician’s choice plus trastuzumab in patients with previously treated, anthracycline-naïve, HER2-positive, locally advanced/metastatic breast cancer

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• Study protocol

Kathy Miller, Javier Cortes, Sara A. Hurvitz, Ian E. Krop, Debu Tripathy, Sunil Verma, Kaveh Riahi, Joseph G. Reynolds, Thomas J. Wickham, Istvan Molnar, Denise A. Yardley

A functional microRNA library screen reveals miR-410 as a novel anti-apoptotic regulator of cholangiocarcinoma

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Tiziana Palumbo, George A. Poultsides, Grigorios Kouraklis, Theodore Liakakos, Alexandra Drakaki, George Peros, Maria Hatziapostolou, Dimitrios Iliopoulos

Epidermal growth factor signals regulate dihydropyrimidine dehydrogenase expression in EGFR-mutated non-small-cell lung cancer

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Tetsuro Tominaga, Tomoshi Tsuchiya, Koji Mochinaga, Junichi Arai, Naoya Yamasaki, Keitaro Matsumoto, Takuro Miyazaki, Toshiya Nagasaki, Atsushi Nanashima, Kazuhiro Tsukamoto, Takeshi Nagayasu

Time course decomposition of cell heterogeneity in TFEB signaling states reveals homeostatic mechanisms restricting the magnitude and duration of TFEB responses to mTOR activity modulation

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Paula Andrea Marin Zapata, Carsten Jörn Beese, Anja Jünger, Giovanni Dalmasso, Nathan Ryan Brady, Anne Hamacher-Brady

Factors influencing diagnosis delay of advanced breast cancer in Moroccan women

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A. Maghous, F. Rais, S. Ahid, N. Benhmidou, K. Bellahamou, H. Loughlimi, E. Marnouche, S. Elmajjaoui, H. Elkacemi, T. Kebdani, N. Benjaafar

Patients with hepatic breast cancer metastases demonstrate highly specific profiles of matrix metalloproteinases MMP-2 and MMP-9 after SIRT treatment as compared to other primary and secondary liver tumours

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Olga Golubnitschaja, Kristina Yeghiazaryan, Helena Stricker, Daniela Trog, Hans H. Schild, Leonard Berliner

Comparative expression patterns and diagnostic efficacies of SR splicing factors and HNRNPA1 in gastric and colorectal cancer

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Won Cheol Park, Hak-Ryul Kim, Dong Baek Kang, Jae-Suk Ryu, Keum-Ha Choi, Gyeong-Ok Lee, Ki Jung Yun, Keun Young Kim, Raekil Park, Kwon-Ha Yoon, Ji-Hyun Cho, Young-Jin Lee, Soo-Cheon Chae, Min-Cheol Park, Do-Sim Park

Osteopontin regulates proliferation, apoptosis, and migration of murine claudin-low mammary tumor cells

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S. Saleh, D. E. Thompson, J. McConkey, P. Murray, R. A. Moorehead

Safety and feasibility of fasting in combination with platinum-based chemotherapy

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Tanya B. Dorff, Susan Groshen, Agustin Garcia, Manali Shah, Denice Tsao-Wei, Huyen Pham, Chia-Wei Cheng, Sebastian Brandhorst, Pinchas Cohen, Min Wei, Valter Longo, David I. Quinn

Stimulation of triple negative breast cancer cell migration and metastases formation is prevented by chloroquine in a pre-irradiated mouse model

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Gina Bouchard, Hélène Therriault, Sameh Geha, Yves Bérubé-Lauzière, Rachel Bujold, Caroline Saucier, Benoit Paquette

Can advanced new radiation therapy technologies improve outcome of high grade glioma (HGG) patients? analysis of 3D-conformal radiotherapy (3DCRT) versus volumetric-modulated arc therapy (VMAT) in patients treated with surgery, concomitant and adjuvant chemo-radiotherapy

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Pierina Navarria, Federico Pessina, Luca Cozzi, Anna Maria Ascolese, Francesca Lobefalo, Antonella Stravato, Giuseppe D’Agostino, Ciro Franzese, Manuela Caroli, Lorenzo Bello, Marta Scorsetti

MYC and BCL2 overexpression is associated with a higher class of Memorial Sloan-Kettering Cancer Center prognostic model and poor clinical outcome in primary diffuse large B-cell lymphoma of the central nervous system

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Sehui Kim, Soo Jeong Nam, Dohee Kwon, Hannah Kim, Eunyoung Lee, Tae Min Kim, Dae Seog Heo, Sung Hye Park, Chul Woo Kim, Yoon Kyung Jeon

Variation in use of targeted therapies for metastatic renal cell carcinoma: Results from a Dutch population-based registry

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S. De Groot, S. Sleijfer, W. K. Redekop, E. Oosterwijk, J. B. A. G. Haanen, L. A. L. M. Kiemeney, C. A. Uyl-de Groot

Unusual association of non-anaplastic Wilms tumor and Cornelia de Lange syndrome: case report

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• Case report

Claudia Santoro, Andrea Apicella, Fiorina Casale, Angela La Manna, Martina Di Martino, Daniela Di Pinto, Cristiana Indolfi, Silverio Perrotta

PTEN mRNA expression is less pronounced in left- than right-sided colon cancer: a retrospective observational study

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Hidekazu Kuramochi, Ayako Nakamura, Go Nakajima, Yuka Kaneko, Tatsuo Araida, Masakazu Yamamoto, Kazuhiko Hayashi

Molecular analyses of unselected head and neck cancer cases demonstrates that human papillomavirus transcriptional activity is positively associated with survival and prognosis

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Liam Masterson, David M. Winder, Siolian L. R. Ball, Katie Vaughan, Martin Lehmann, Lars-Uwe Scholtz, Jane C. Sterling, Holger H. Sudhoff, Peter K. C. Goon

A comparison of 12-gene colon cancer assay gene expression in African American and Caucasian patients with stage II colon cancer

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Rangaswamy Govindarajan, James Posey, Calvin Y. Chao, Ruixiao Lu, Trafina Jadhav, Ahmed Y. Javed, Awais Javed, Fade A. Mahmoud, Raymond U. Osarogiagbon, Upender Manne

Erratum to: A phase 1b study of Selumetinib in combination with Cisplatin and Gemcitabine in advanced or metastatic biliary tract cancer: the ABC-04 study

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• Erratum

John Bridgewater, Andre Lopes, Sandra Beare, Marian Duggan, Dymphna Lee, Maravic Ricamara, Delyth McEntee, Ajithkumar Sukumaran, Harpreet Wasan, Juan W. Valle

Erratum to: The effect of soluble E-selectin on tumor progression and metastasis

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• Erratum

Shin-Ae Kang, Celine A. Blache, Sandra Bajana, Nafis Hasan, Mohamed Kamal, Yoshihiro Morita, Vineet Gupta, Bilegtsaikhan Tsolmon, K. Stephen Suh, David G. Gorenstein, Wajeeha Razaq, Hallgeir Rui, Takemi Tanaka

Tissue metabolic profiling of human gastric cancer assessed by 1H NMR

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Huijuan Wang, Hailong Zhang, Pengchi Deng, Chunqi Liu, Dandan Li, Hui Jie, Hu Zhang, Zongguang Zhou, Ying-Lan Zhao

Debate: adjuvant whole brain radiotherapy or not? More data is the wiser choice

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• Debate

Gerald B. Fogarty, Angela Hong, Vinai Gondi, Bryan Burmeister, Kari Jacobsen, Serigne Lo, Elizabeth Paton, Brindha Shivalingam, John F. Thompson

Prognostic significance of p53 expression in patients with esophageal cancer: a meta-analysis

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Lianghai Wang, Xiaodan Yu, Jing Li, Zhiyu Zhang, Jun Hou, Feng Li

Erratum to: Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses vasculogenic mimicry and proliferation of highly aggressive pancreatic cancer PaTu8988 cells

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• Erratum

Xing-dong Xu, Lan Yang, Li-yun Zheng, Yan-yan Pan, Zhi-fei Cao, Zhi-qing Zhang, Quan-sheng Zhou, Bo Yang, Cong Cao

Long-term survival and BRCA status in male breast cancer: a retrospective single-center analysis

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Piera Gargiulo, Matilde Pensabene, Monica Milano, Grazia Arpino, Mario Giuliano, Valeria Forestieri, Caterina Condello, Rossella Lauria, Sabino De Placido

Context dependent regulatory patterns of the androgen receptor and androgen receptor target genes

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Jan Roger Olsen, Waqas Azeem, Margrete Reime Hellem, Kristo Marvyin, Yaping Hua, Yi Qu, Lisha Li, Biaoyang Lin, XI-Song Ke, Anne Margrete Øyan, Karl-Henning Kalland

Systematic drug screening reveals specific vulnerabilities and co-resistance patterns in endocrine-resistant breast cancer

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Sara Kangaspeska, Susanne Hultsch, Alok Jaiswal, Henrik Edgren, John-Patrick Mpindi, Samuli Eldfors, Oscar Brück, Tero Aittokallio, Olli Kallioniemi

Suppression of cell migration is promoted by miR-944 through targeting of SIAH1 and PTP4A1 in breast cancer cells

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Ali Flores-Pérez, Laurence A. Marchat, Sergio Rodríguez-Cuevas, Verónica Piña Bautista, Lizeth Fuentes-Mera, Diana Romero-Zamora, Anabel Maciel-Dominguez, Olga Hernández de la Cruz, Miguel Fonseca-Sánchez, Erika Ruíz-García, Horacio Astudillo-de la Vega, César López-Camarillo

Transanal total mesorectal excision (taTME) for rectal cancer: a systematic review and meta-analysis of oncological and perioperative outcomes compared with laparoscopic total mesorectal excision

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Bin Ma, Peng Gao, Yongxi Song, Cong Zhang, Changwang Zhang, Longyi Wang, Hongpeng Liu, Zhenning Wang

Survival rates of cancer patients with and without rheumatic disease: a retrospective cohort analysis

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Jin Kyun Park, Ji Ae Yang, Eun Young Ahn, Sung Hae Chang, Yeong Wook Song, Jeffrey R. Curtis, Eun Bong Lee

Comparison of the miRNA profiles in HPV-positive and HPV-negative tonsillar tumors and a model system of human keratinocyte clones

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Zuzana Vojtechova, Ivan Sabol, Martina Salakova, Jana Smahelova, Jiri Zavadil, Lubomir Turek, Marek Grega, Jan Klozar, Bohumir Prochazka, Ruth Tachezy

Metalloproteases meprin-ɑ (MEP1A) is a prognostic biomarker and promotes proliferation and invasion of colorectal cancer

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Xiao Wang, Jian Chen, Jingtao Wang, Fudong Yu, Senlin Zhao, Yu Zhang, Huamei Tang, Zhihai Peng

Cetuximab-induced aseptic meningitis: case report and review of a rare adverse event

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Christophe Maritaz, Carole Metz, Nabil Baba-Hamed, Méryam Jardin-Szucs, Gaël Deplanque

Bone alkaline phosphatase as a surrogate marker of bone metastasis in gastric cancer patients

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Sun Min Lim, Youn Nam Kim, Ki Hyun Park, Beodeul Kang, Hong Jae Chon, Chan Kim, Joo Hoon Kim, Sun Young Rha

TAS-102, the first “cardio-gentle” fluoropyrimidine in the colorectal cancer landscape?

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• Debate

Fausto Petrelli, Sandro Barni, Paola Bertocchi, Alberto Zaniboni

Lifestyle in Multiple Myeloma - a longitudinal cohort study protocol

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• Study protocol

M. Heinrich, A. Fisher, B. Paton, O. McCourt, R. J. Beeken, A. Hackshaw, J. Wardle, K. Yong

CD80 down-regulation is associated to aberrant DNA methylation in non-inflammatory colon carcinogenesis

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Marco Scarpa, Melania Scarpa, Ignazio Castagliuolo, Francesca Erroi, Silvia Basato, Paola Brun, Imerio Angriman, Carlo Castoro

The use of a multiple imputation method to investigate the trends in Histologic types of lung cancer in Songkhla province, Thailand, 1989–2013

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Hutcha Sriplung, Seesai Yeesoonsang, Edward McNeil, Surichai Bilheem

A case of lymphangioleiomyomatosis associated with endometrial cancer and severe systemic lupus erythematosus

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• Case report

Kensuke Suzuki, Kazunori Nagasaka, Katsutoshi Oda, Hiroyuki Abe, Daichi Maeda, Yoko Matsumoto, Takahide Arimoto, Kei Kawana, Masashi Fukayama, Yutaka Osuga, Tomoyuki Fujii

Expansive hematoma in delayed cerebral radiation necrosis in patients treated with T-DM1: a report of two cases

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Koichi Mitsuya, Junichiro Watanabe, Yoko Nakasu, Nakamasa Hayashi, Hideyuki Harada, Ichiro Ito

Use and misuse of common terminology criteria for adverse events in cancer clinical trials

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Sheng Zhang, Fei Liang, Ian Tannock

GSK-3 directly regulates phospho-4EBP1 in renal cell carcinoma cell-line: an intrinsic subcellular mechanism for resistance to mTORC1 inhibition

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Hiromi Ito, Osamu Ichiyanagi, Sei Naito, Vladimir N. Bilim, Yoshihiko Tomita, Tomoyuki Kato, Akira Nagaoka, Norihiko Tsuchiya

Prognostic and predictive significance of tumor length in patients with esophageal squamous cell carcinoma undergoing radical resection

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Jie Wu, Qi-Xun Chen

Occupational prestige, social mobility and the association with lung cancer in men

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Thomas Behrens, Isabelle Groß, Jack Siemiatycki, David I. Conway, Ann Olsson, Isabelle Stücker, Florence Guida, Karl-Heinz Jöckel, Hermann Pohlabeln, Wolfgang Ahrens, Irene Brüske, Heinz-Erich Wichmann, Per Gustavsson, Dario Consonni, Franco Merletti, Lorenzo Richiardi, Lorenzo Simonato, Cristina Fortes, Marie-Elise Parent, John McLaughlin, Paul Demers, Maria Teresa Landi, Neil Caporaso, David Zaridze, Neonila Szeszenia-Dabrowska, Peter Rudnai, Jolanta Lissowska, Eleonora Fabianova, Adonina Tardón, John K. Field, Rodica Stanescu Dumitru, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Hans Kromhout, Roel Vermeulen, Paolo Boffetta, Kurt Straif, Joachim Schüz, Jan Hovanec, Benjamin Kendzia, Beate Pesch, Thomas Brüning

Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer

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Jun Kasuga, Takashi Kawahara, Daiji Takamoto, Sachi Fukui, Takashi Tokita, Tomoyuki Tadenuma, Masaki Narahara, Syusei Fusayasu, Hideyuki Terao, Koji Izumi, Hiroki Ito, Yusuke Hattori, Jun-ichi Teranishi, Takeshi Sasaki, Kazuhide Makiyama, Yasuhide Miyoshi, Masahiro Yao, Yasushi Yumura, Hiroshi Miyamoto, Hiroji Uemura

INFα-2b inhibitory effects on CD4+CD25+FOXP3+ regulatory T cells in the tumor microenvironment of C57BL/6 J mice with melanoma xenografts

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Yang Yu, Run Huang, Xiangyun Zong, Xiangming He, Wenju Mo

Technical validation of an RT-qPCR in vitro diagnostic test system for the determination of breast cancer molecular subtypes by quantification of ERBB2, ESR1, PGR and MKI67 mRNA levels from formalin-fixed paraffin-embedded breast tumor specimens

• Open Access
• Technical advance

Mark Laible, Kornelia Schlombs, Katharina Kaiser, Elke Veltrup, Stefanie Herlein, Sotiris Lakis, Robert Stöhr, Sebastian Eidt, Arndt Hartmann, Ralph M. Wirtz, Ugur Sahin

Epigenetic silencing of serine protease HTRA1 drives polyploidy

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Nina Schmidt, Inga Irle, Kamilla Ripkens, Vanda Lux, Jasmin Nelles, Christian Johannes, Lee Parry, Kirsty Greenow, Sarah Amir, Mara Campioni, Alfonso Baldi, Chio Oka, Masashi Kawaichi, Alan R. Clarke, Michael Ehrmann

Prognostic and clinical impact of PIK3CA mutation in gastric cancer: pyrosequencing technology and literature review

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Kazuto Harada, Yoshifumi Baba, Hironobu Shigaki, Takatsugu Ishimoto, Keisuke Miyake, Keisuke Kosumi, Ryuma Tokunaga, Daisuke Izumi, Mayuko Ohuchi, Kenichi Nakamura, Yuki Kiyozumi, Junji Kurashige, Masaaki Iwatsuki, Yuji Miyamoto, Yasuo Sakamoto, Naoya Yoshida, Masayuki Watanabe, Hideo Baba

Detection of circulating tumor cells using manually performed immunocytochemistry (MICC) does not correlate with outcome in patients with early breast cancer – Results of the German SUCCESS-A- trial

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Julia Jueckstock, Brigitte Rack, Thomas W. P. Friedl, Christoph Scholz, Julia Steidl, Elisabeth Trapp, Hans Tesch, Helmut Forstbauer, Ralf Lorenz, Mahdi Rezai, Lothar Häberle, Marianna Alunni-Fabbroni, Andreas Schneeweiss, Matthias W. Beckmann, Werner Lichtenegger, Peter A. Fasching, Klaus Pantel, Wolfgang Janni

Pre-diagnostic body mass index and weight change in relation to colorectal cancer survival among incident cases from a population-based cohort study

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Ida Laake, Inger K. Larsen, Randi Selmer, Inger Thune, Marit B. Veierød

Chemotherapy versus radiotherapy for FIGO stages IB1 and IIA1 cervical carcinoma patients with postoperative isolated deep stromal invasion: a retrospective study

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Lei Li, XiaoYan Song, RuoNan Liu, Nan Li, Ye Zhang, Yan Cheng, HongTu Chao, LiYing Wang

Eribulin-induced liver dysfunction as a prognostic indicator of survival of metastatic breast cancer patients: a retrospective study

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Takayuki Kobayashi, Jyunichi Tomomatsu, Ippei Fukada, Tomoko Shibayama, Natsuki Teruya, Yoshinori Ito, Takuji Iwase, Shinji Ohno, Shunji Takahashi

A cost effective analysis of fixed-dose combination of dutasteride and tamsulosin compared with dutasteride monotherapy for benign prostatic hyperplasia in Nigeria: a middle income perspective; using an interactive Markov model

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Emeka I. Udeh, Chimaobi G. Ofoha, David A. Adewole, Ikenna I. Nnabugwu

EGFR gene amplification is relatively common and associates with outcome in intestinal adenocarcinoma of the stomach, gastro-oesophageal junction and distal oesophagus

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Eva-Maria Birkman, Annika Ålgars, Minnamaija Lintunen, Raija Ristamäki, Jari Sundström, Olli Carpén

Metabolic syndrome is associated with advanced prostate cancer in patients treated with radical retropubic prostatectomy: results from a multicentre prospective study

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Cosimo De Nunzio, Giuseppe Simone, Aldo Brassetti, Riccardo Mastroianni, Devis Collura, Giovanni Muto, Michele Gallucci, Andrea Tubaro

Psychosocial impact of prognostic genetic testing in the care of uveal melanoma patients: protocol of a controlled prospective clinical observational study

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• Study protocol

Yesim Erim, Jennifer Scheel, Anja Breidenstein, Claudia HD Metz, Dietmar Lohmann, Hans-Christoph Friederich, Sefik Tagay

Interleukin-22 is elevated in lavage from patients with lung cancer and other pulmonary diseases

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Amanda Tufman, Rudolf Maria Huber, Stefanie Völk, Frederic Aigner, Martin Edelmann, Fernando Gamarra, Rosemarie Kiefl, Kathrin Kahnert, Fei Tian, Anne-Laure Boulesteix, Stefan Endres, Sebastian Kobold

Clinicopathological and prognostic significance of GPX2 protein expression in esophageal squamous cell carcinoma

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Zhijin Lei, Dongping Tian, Chong Zhang, Shukun Zhao, Min Su

Fluorescent imaging of superficial head and neck squamous cell carcinoma using a γ-glutamyltranspeptidase-activated targeting agent: a pilot study

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Takeshi Mizushima, Shunsuke Ohnishi, Yuichi Shimizu, Yutaka Hatanaka, Kanako C. Hatanaka, Hidetaka Hosono, Yoshimasa Kubota, Mitsuteru Natsuizaka, Mako Kamiya, Shouko Ono, Akihiro Homma, Mototsugu Kato, Naoya Sakamoto, Yasuteru Urano

Survival, safety, and prognostic factors for outcome with Regorafenib in patients with metastatic colorectal cancer refractory to standard therapies: results from a multicenter study (REBECCA) nested within a compassionate use program

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Antoine Adenis, Christelle de la Fouchardiere, Bernard Paule, Pascal Burtin, David Tougeron, Jennifer Wallet, Louis-Marie Dourthe, Pierre-Luc Etienne, Laurent Mineur, Stéphanie Clisant, Jean-Marc Phelip, Andrew Kramar, Thierry Andre

Melanoma-specific mortality and competing mortality in patients with non-metastatic malignant melanoma: a population-based analysis

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Weidong Shen, Naoko Sakamoto, Limin Yang

Mammographic density and structural features can individually and jointly contribute to breast cancer risk assessment in mammography screening: a case–control study

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Rikke Rass Winkel, My von Euler-Chelpin, Mads Nielsen, Kersten Petersen, Martin Lillholm, Michael Bachmann Nielsen, Elsebeth Lynge, Wei Yao Uldall, Ilse Vejborg

Tumor-suppressive effects of atelocollagen-conjugated hsa-miR-520d-5p on un-differentiated cancer cells in a mouse xenograft model

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Yoshitaka Ishihara, Satoshi Tsuno, Satoshi Kuwamoto, Taro Yamashita, Yusuke Endo, Keigo Miura, Yugo Miura, Takemasa Sato, Junichi Hasegawa, Norimasa Miura

ColoNav: patient navigation for colorectal cancer screening in deprived areas – Study protocol

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• Study protocol

C. Allary, A. Bourmaud, F. Tinquaut, M. Oriol, J. Kalecinski, V. Dutertre, N. Lechopier, M. Pommier, Y. Benoist, S. Rousseau, V. Regnier, V. Buthion, F. Chauvin

Predictive factors for a long-term response duration in non-squamous cell lung cancer patients treated with pemetrexed

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Sojung Park, Hyun Jung Kim, Chang–Min Choi, Dae Ho Lee, Sang–We Kim, Jung–Shin Lee, Woo Sung Kim, Se Hoon Choi, Jin Kyung Rho, Jae Cheol Lee

Metformin treatment modulates the tumour-induced wasting effects in muscle protein metabolism minimising the cachexia in tumour-bearing rats

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André G. Oliveira, Maria Cristina C. Gomes-Marcondes

Macrophage phenotypic subtypes diametrically regulate epithelial-mesenchymal plasticity in breast cancer cells

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Min Yang, Bo Ma, Hanshuang Shao, Amanda M. Clark, Alan Wells

A phase I trial of the trifunctional anti Her2 × anti CD3 antibody ertumaxomab in patients with advanced solid tumors

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N. Haense, A. Atmaca, C. Pauligk, K. Steinmetz, F. Marmé, G. M. Haag, M. Rieger, O. G. Ottmann, P. Ruf, H. Lindhofer, S.-E. Al-Batran

Comparing the case mix and survival of women receiving breast cancer care from one private provider with other London women with breast cancer: pilot data exchange and analyses

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Elizabeth A. Davies, Victoria H. Coupland, Steve Dixon, Kefah Mokbel, Ruth H. Jack

Increased toll-like receptors and p53 levels regulate apoptosis and angiogenesis in non-muscle invasive bladder cancer: mechanism of action of P-MAPA biological response modifier

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Patrick Vianna Garcia, Fábio Rodrigues Ferreira Seiva, Amanda Pocol Carniato, Wilson de Mello Júnior, Nelson Duran, Alda Maria Macedo, Alexandre Gabarra de Oliveira, Rok Romih, Iseu da Silva Nunes, Odilon da Silva Nunes, Wagner José Fávaro

Delphinidin-3-glucoside suppresses breast carcinogenesis by inactivating the Akt/HOTAIR signaling pathway

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Xiaohong Yang, En Luo, Xin Liu, Bin Han, Xiaoping Yu, Xiaoli Peng

Optimal staging system for predicting the prognosis of patients with hepatocellular carcinoma in China: a retrospective study

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Lihui Su, Tao Zhou, Zongli Zhang, Xiuguo Zhang, Xuting Zhi, Caixia Li, Qingliang Wang, Chongqi Jia, Wenna Shi, Yanqiu Yue, Yanjing Gao, Baoquan Cheng

The eicosanoids leukotriene D4 and prostaglandin E2 promote the tumorigenicity of colon cancer-initiating cells in a xenograft mouse model

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Kishan Bellamkonda, Naveen Kumar Chandrashekar, Janina Osman, Benson Chellakkan Selvanesan, Sayeh Savari, Anita Sjölander

Increasing incidence of thyroid cancer in the Nordic countries with main focus on Swedish data

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Michael Carlberg, Lena Hedendahl, Mikko Ahonen, Tarmo Koppel, Lennart Hardell

The impact of disease-related symptoms and palliative care concerns on health-related quality of life in multiple myeloma: a multi-centre study

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Christina Ramsenthaler, Thomas R. Osborne, Wei Gao, Richard J. Siegert, Polly M. Edmonds, Stephen A. Schey, Irene J. Higginson

Serum HER2 extra-cellular domain, S100ß and CA 15-3 levels are independent prognostic factors in metastatic breast cancer patients

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Amélie Darlix, Pierre-Jean Lamy, Evelyne Lopez-Crapez, Antoine Laurent Braccini, Nelly Firmin, Gilles Romieu, Simon Thezenas, William Jacot

Efficacy of sorafenib in BRAF-mutated non-small-cell lung cancer (NSCLC) and no response in synchronous BRAF wild type-hepatocellular carcinoma: a case report

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• Case report

Andrea Casadei Gardini, Elisa Chiadini, Luca Faloppi, Giorgia Marisi, Angelo Delmonte, Mario Scartozzi, Cristian Loretelli, Alessandro Lucchesi, Devil Oboldi, Alessandra Dubini, Giovanni Luca Frassineti, Paola Ulivi

Factors associated with late recurrence after completion of 5-year adjuvant tamoxifen in estrogen receptor positive breast cancer

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Eun-Shin Lee, Wonshik Han, Min Kyoon Kim, Jongjin Kim, Tae-kyung Yoo, Moo Hyun Lee, Kyung Hun Lee, Tae Yong Kim, Hyeong-Gon Moon, Seock-Ah Im, Dong-Young Noh, Eun Sook Lee

Involvement of DNMT 3B promotes epithelial-mesenchymal transition and gene expression profile of invasive head and neck squamous cell carcinomas cell lines

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Li-Hsuen Chen, Wen-Lin Hsu, Yen-Ju Tseng, Dai-Wei Liu, Ching-Feng Weng

Coalition of Oct4A and β1 integrins in facilitating metastasis in ovarian cancer

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Chantel Samardzija, Rodney B. Luwor, Michael A. Quinn, George Kannourakis, Jock K. Findlay, Nuzhat Ahmed

Prognostic impact of circulating tumor cell apoptosis and clusters in serial blood samples from patients with metastatic breast cancer in a prospective observational cohort

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Sara Jansson, Pär-Ola Bendahl, Anna-Maria Larsson, Kristina E. Aaltonen, Lisa Rydén

Prognostic implications of PD-L1 expression in patients with soft tissue sarcoma

• Open Access
• Research article

Chan Kim, Eun Kyung Kim, Hun Jung, Hong Jae Chon, Jung Woo Han, Kyoo-Ho Shin, Hyuk Hu, Kyung Sik Kim, Young Deuk Choi, Sunghoon Kim, Young Han Lee, Jin-Suck Suh, Joong Bae Ahn, Hyun Cheol Chung, Sung Hoon Noh, Sun Young Rha, Soo Hee Kim, Hyo Song Kim

Colorectal cancer health services research study protocol: the CCR-CARESS observational prospective cohort project

• Open Access
• Study protocol

José M. Quintana, Nerea Gonzalez, Ane Anton-Ladislao, Maximino Redondo, Marisa Bare, Nerea Fernandez de Larrea, Eduardo Briones, Antonio Escobar, Cristina Sarasqueta, Susana Garcia-Gutierrez, Urko Aguirre, Jose María Quintana, Marisa Baré, Maximino Redondo, Eduardo Briones, Nerea Fernández de Larrea, Cristina Sarasqueta, Antonio Escobar, Francisco Rivas, Maria M. Morales-Suárez-, Juan Antonio Blasco, Isabel del Cura, Inmaculada Arostegui, Amaia Bilbao, Nerea González, Susana García-Gutiérrez, Iratxe Lafuente, Urko Aguirre, Miren Orive, Josune Martin, Ane Antón-Ladislao, Núria Torà, Marina Pont, María Purificación Martínez del Prado, Alberto Loizate, Ignacio Zabalza, José Errasti, Antonio Z Gimeno, Santiago Lázaro, Mercè Comas, Jose María Enríquez, Carlos Placer, Amaia Perales, Iñaki Urkidi, Jose María Erro, Enrique Cormenzana, Adelaida Lacasta, Pep Piera Pibernat, Elena Campano, Ana Isabel Sotelo, Segundo Gómez-Abril, F. Medina-Cano, Julia Alcaide, Arturo Del Rey-Moreno, Manuel Jesús Alcántara, Rafael Campo, Alex Casalots, Carles Pericay, Maria José Gil, Miquel Pera, Pablo Collera, Josep Alfons Espinàs, Mercedes Martínez, Mireia Espallargues, Caridad Almazán, Paula Dujovne Lindenbaum, José María Fernández-Cebrián, Rocío Anula Fernández, Julio Ángel Mayol, Ramón Cantero, Héctor Guadalajara, María Heras, Damián García, Mariel Morey, Javier Mar

Changes of Socio-demographic data of clients seeking genetic counseling for hereditary breast and ovarian cancer due to the “Angelina Jolie Effect”

• Open Access
• Research article

Christine Staudigl, Georg Pfeiler, Katharina Hrauda, Romana Renz, Andreas Berger, Renate Lichtenschopf, Christian F. Singer, Muy-Kheng M. Tea

Comparison of weekly administration of cisplatin versus three courses of cisplatin 100 mg/m2 for definitive radiochemotherapy of locally advanced head-and-neck cancers

• Open Access
• Research article

Dirk Rades, Daniel Seidl, Stefan Janssen, Amira Bajrovic, Katarina Karner, Primoz Strojan, Steven E Schild

Total antioxidant intake and prostate cancer in the Cancer of the Prostate in Sweden (CAPS) study. A case control study

• Open Access
• Research article

Kjell M. Russnes, Elisabeth Möller, Kathryn M. Wilson, Monica Carlsen, Rune Blomhoff, Sigbjørn Smeland, Hans-Olov Adami, Henrik Grönberg, Lorelei A. Mucci, Katarina Bälter

The triptolide derivative MRx102 inhibits Wnt pathway activation and has potent anti-tumor effects in lung cancer

• Open Access
• Research article

Theresa A. Reno, Sun-Wing Tong, Jun Wu, John M. Fidler, Rebecca Nelson, Jae Y. Kim, Dan J. Raz

The anti-tumor effect of the quinoline-3-carboxamide tasquinimod: blockade of recruitment of CD11b+ Ly6Chi cells to tumor tissue reduces tumor growth

• Open Access
• Research article

Adnan Deronic, Sahar Tahvili, Tomas Leanderson, Fredrik Ivars

Osteopontin splice variants are differential predictors of breast cancer treatment responses

• Open Access
• Research article

Krzysztof Zduniak, Anil Agrawal, Siddarth Agrawal, Md Monir Hossain, Piotr Ziolkowski, Georg F. Weber

Clinical relevance of peroxisome proliferator-activated receptor-gamma expression in myxoid liposarcoma

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Akihiko Takeuchi, Norio Yamamoto, Toshiharu Shirai, Katsuhiro Hayashi, Shinji Miwa, Seiichi Munesue, Yasuhiko Yamamoto, Hiroyuki Tsuchiya

Erlotinib plus gemcitabine versus gemcitabine for pancreatic cancer: real-world analysis of Korean national database

• Open Access
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Sangjin Shin, Chan Mi Park, Hanbyeol Kwon, Kyung-Hun Lee

Spinal disease in myeloma: cohort analysis at a specialist spinal surgery centre indicates benefit of early surgical augmentation or bracing

• Open Access
• Research article

Karan Malhotra, Joseph S. Butler, Hai Ming Yu, Susanne Selvadurai, Shirley D’Sa, Neil Rabin, Charalampia Kyriakou, Kwee Yong, Sean Molloy

Implementation of immunochemical faecal occult blood test in general practice: a study protocol using a cluster-randomised stepped-wedge design

• Open Access
• Study protocol

Jakob Søgaard Juul, Flemming Bro, Nete Hornung, Berit Sanne Andersen, Søren Laurberg, Frede Olesen, Peter Vedsted

Population attributable fraction of Esophageal squamous cell carcinoma due to smoking and alcohol in Uganda

• Open Access
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Samson Okello, Cristina Churchill, Rogers Owori, Benson Nasasira, Christine Tumuhimbise, Charles Lagoro Abonga, David Mutiibwa, David C. Christiani, Kathleen E. Corey

Alveolar Rhabdomyosarcoma of the foot metastasizing to the Iris: report of a rare case

• Open Access
• Case report

Ido Didi Fabian, G. Darius Hildebrand, Shaun Wilson, Tina Foord, Mandeep S. Sagoo

Prognostic significance of annexin A2 and annexin A4 expression in patients with cervical cancer

• Open Access
• Research article

Chel Hun Choi, Joon-Yong Chung, Eun Joo Chung, John D. Sears, Jeong-Won Lee, Duk-Soo Bae, Stephen M. Hewitt

Fast-track surgery improves postoperative clinical recovery and cellular and humoral immunity after esophagectomy for esophageal cancer

• Open Access
• Research article

Lantao Chen, Lixin Sun, Yaoguo Lang, Jun Wu, Lei Yao, Jinfeng Ning, Jinfeng Zhang, Shidong Xu

Retrospective and comparative analysis of 99mTc-Sestamibi breast specific gamma imaging versus mammography, ultrasound, and magnetic resonance imaging for the detection of breast cancer in Chinese women

• Open Access
• Research article

Xiuyan Yu, Guoming Hu, Zhigang Zhang, Fuming Qiu, Xuan Shao, Xiaochen Wang, Hongwei Zhan, Yiding Chen, Yongchuan Deng, Jian Huang

Clinical outcomes and prognostic factors of cyberknife stereotactic body radiation therapy for unresectable hepatocellular carcinoma

• Open Access
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Jenny Que, Hsing-Tao Kuo, Li-Ching Lin, Kuei-Li Lin, Chia-Hui Lin, Yu-Wei Lin, Ching-Chieh Yang

Silibinin induces mitochondrial NOX4-mediated endoplasmic reticulum stress response and its subsequent apoptosis

• Open Access
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Sang-Hun Kim, Kwang-Youn Kim, Sun-Nyoung Yu, Young-Kyo Seo, Sung-Sik Chun, Hak-Sun Yu, Soon-Cheol Ahn

Insulin-like growth factor-1 signaling in renal cell carcinoma

• Open Access
• Debate

Adam F. Tracz, Cezary Szczylik, Camillo Porta, Anna M. Czarnecka

Highly sensitive detection of the PIK3CA H1047R mutation in colorectal cancer using a novel PCR-RFLP method

• Open Access
• Research article

Wan-Ming Li, Ting-Ting Hu, Lin-Lin Zhou, Yi-Ming Feng, Yun-Yi Wang, Jin Fang

Combination of a third generation bisphosphonate and replication-competent adenoviruses augments the cytotoxicity on mesothelioma

• Open Access
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Yuanyuan Jiang, Boya Zhong, Kiyoko Kawamura, Takao Morinaga, Masato Shingyoji, Ikuo Sekine, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa

Health professionals and the early detection of head and neck cancers: a population-based study in a high incidence area

• Open Access
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Karine Ligier, Olivier Dejardin, Ludivine Launay, Emmanuel Benoit, Emmanuel Babin, Simona Bara, Bénédicte Lapôtre-Ledoux, Guy Launoy, Anne-Valérie Guizard

COX-2 rs689466, rs5275, and rs20417 polymorphisms and risk of head and neck squamous cell carcinoma: a meta-analysis of adjusted and unadjusted data

• Open Access
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Wei-Dong Leng, Xiu-Jie Wen, Joey S. W. Kwong, Wei Huang, Jian-Gang Chen, Xian-Tao Zeng

5-lipoxygenase mediates docosahexaenoyl ethanolamide and N-arachidonoyl-L-alanine-induced reactive oxygen species production and inhibition of proliferation of head and neck squamous cell carcinoma cells

• Open Access
• Research article

Seok-Woo Park, J. Hun Hah, Sang-Mi Oh, Woo-Jin Jeong, Myung-Whun Sung

The impact of breast cancer biological subtyping on tumor size assessment by ultrasound and mammography - a retrospective multicenter cohort study of 6543 primary breast cancer patients

• Open Access
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Roland Gregor Stein, Daniel Wollschläger, Rolf Kreienberg, Wolfgang Janni, Manfred Wischnewsky, Joachim Diessner, Tanja Stüber, Catharina Bartmann, Mathias Krockenberger, Jörg Wischhusen, Achim Wöckel, Maria Blettner, Lukas Schwentner

Poor survival in stage IIB/C (T4N0) compared to stage IIIA (T1-2 N1, T1N2a) colon cancer persists even after adjusting for adequate lymph nodes retrieved and receipt of adjuvant chemotherapy

• Open Access
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Quyen D. Chu, Meijiao Zhou, Kaelen L. Medeiros, Prakash Peddi, Mindie Kavanaugh, Xiao-Cheng Wu

Combination of VP3 and CD147-knockdown enhance apoptosis and tumor growth delay index in colorectal tumor allograft

• Open Access
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Ruzila Ismail, Zeenathul Nazariah Allaudin, Rasedee Abdullah, Mohd-Azmi Mohd Lila, Nik-Mohd-Afizan Nik Abd. Rahman, Sheikh-Omar Abdul Rahman

Antitumour responses induced by a cell-based Reovirus vaccine in murine lung and melanoma models

• Open Access
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Ciorsdan A. Campion, Declan Soden, Patrick F. Forde

Pleural fluid osteopontin, vascular endothelial growth factor, and urokinase-type plasminogen activator levels as predictors of pleurodesis outcome and prognosticators in patients with malignant pleural effusion: a prospective cohort study

• Open Access
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Li-Han Hsu, Pei-Chi Hsu, Tien-Ling Liao, An-Chen Feng, Nei-Min Chu, Shu-Huei Kao

Phase I/II dose-finding study of nanoparticle albumin-bound paclitaxel (nab®-Paclitaxel) plus Cisplatin as Treatment for Metastatic Nasopharyngeal Carcinoma

• Open Access
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Yan Huang, Wenhua Liang, Yunpeng Yang, Liping Zhao, Hongyun Zhao, Xuan Wu, Yuanyuan Zhao, Yang Zhang, Li Zhang

The overexpression of p16 is not a surrogate marker for high-risk human papilloma virus genotypes and predicts clinical outcomes for vulvar cancer

• Open Access
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Jacek J. Sznurkowski, Anton Żawrocki, Wojciech Biernat

A pilot study to determine the timing and effect of bevacizumab on vascular normalization of metastatic brain tumors in breast cancer

• Open Access
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Bang-Bin Chen, Yen-Shen Lu, Ching-Hung Lin, Wei-Wu Chen, Pei-Fang Wu, Chao-Yu Hsu, Chih-Wei Yu, Shwu-Yuan Wei, Ann-Lii Cheng, Tiffany Ting-Fang Shih

Chemotherapy induced neutropenia at 1-month mark is a predictor of overall survival in patients receiving TAS-102 for refractory metastatic colorectal cancer: a cohort study

• Open Access
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Pashtoon M. Kasi, Daisuke Kotani, Michael Cecchini, Kohei Shitara, Atsushi Ohtsu, Ramesh K. Ramanathan, Howard S. Hochster, Axel Grothey, Takayuki Yoshino

Neoadjuvant irinotecan, cisplatin, and concurrent radiation therapy with celecoxib for patients with locally advanced esophageal cancer

• Open Access
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James M. Cleary, Harvey J. Mamon, Jackie Szymonifka, Raphael Bueno, Noah Choi, Dean M. Donahue, Panos M. Fidias, Henning A. Gaissert, Michael T. Jaklitsch, Matthew H. Kulke, Thomas P. Lynch, Steven J. Mentzer, Jeffrey A. Meyerhardt, Richard S. Swanson, John Wain, Charles S. Fuchs, Peter C. Enzinger

Differential cytotoxicity induced by the Titanium(IV)Salan complex Tc52 in G2-phase independent of DNA damage

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Theresa Pesch, Harald Schuhwerk, Philippe Wyrsch, Timo Immel, Wilhelm Dirks, Alexander Bürkle, Thomas Huhn, Sascha Beneke

EHD1 confers resistance to cisplatin in non-small cell lung cancer by regulating intracellular cisplatin concentrations

• Open Access
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Jing Gao, Qingwei Meng, Yanbin Zhao, Xuesong Chen, Li Cai

SOX2 expression is associated with a cancer stem cell state and down-regulation of CDX2 in colorectal cancer

• Open Access
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Ida V. Lundberg, Sofia Edin, Vincy Eklöf, Åke Öberg, Richard Palmqvist, Maria L. Wikberg

PROX1 and β-catenin are prognostic markers in pancreatic ductal adenocarcinoma

• Open Access
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Kapo Saukkonen, Jaana Hagström, Harri Mustonen, Anne Juuti, Stig Nordling, Pauliina Kallio, Kari Alitalo, Hanna Seppänen, Caj Haglund

Modeling and simulation of maintenance treatment in first-line non-small cell lung cancer with external validation

• Open Access
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Kelong Han, Laurent Claret, Alan Sandler, Asha Das, Jin Jin, Rene Bruno

Erratum to: Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice

• Open Access
• Erratum

J. R. Hens, I. Sinha, F. Perodin, T. Cooper, R. Sinha, J. Plummer, C. E. Perrone, D. Orentreich

No preclinical rationale for IGF1R directed therapy in chondrosarcoma of bone

• Open Access
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Elisabeth F. P. Peterse, Arjen H. G. Cleven, Yvonne De Jong, Inge Briaire-de Bruijn, Jonathan A. Fletcher, Erik H. J. Danen, Anne-Marie Cleton-Jansen, Judith V. M. G. Bovée

Bile acids destabilise HIF-1α and promote anti-tumour phenotypes in cancer cell models

• Open Access
• Research article

J. P. Phelan, F. J. Reen, N. Dunphy, R. O’Connor, F. O’Gara

Method for semi-automated microscopy of filtration-enriched circulating tumor cells

• Open Access
• Technical advance

Emma Pailler, Marianne Oulhen, Fanny Billiot, Alexandre Galland, Nathalie Auger, Vincent Faugeroux, Corinne Laplace-Builhé, Benjamin Besse, Yohann Loriot, Maud Ngo-Camus, Merouan Hemanda, Colin R. Lindsay, Jean-Charles Soria, Philippe Vielh, Françoise Farace

Clinicopathological features and prognosis of gastric cancer in young patients

• Open Access
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Shushang Liu, Fan Feng, Guanghui Xu, Zhen Liu, Yangzi Tian, Man Guo, Xiao Lian, Lei Cai, Daiming Fan, Hongwei Zhang

Results of sub-analysis of a phase 2 study on trabectedin treatment for extraskeletal myxoid chondrosarcoma and mesenchymal chondrosarcoma

• Open Access
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Hideo Morioka, Shunji Takahashi, Nobuhito Araki, Hideshi Sugiura, Takafumi Ueda, Mitsuru Takahashi, Tsukasa Yonemoto, Hiroaki Hiraga, Toru Hiruma, Toshiyuki Kunisada, Akihiko Matsumine, Michiro Susa, Robert Nakayama, Kazumasa Nishimoto, Kazutaka Kikuta, Keisuke Horiuchi, Akira Kawai

Serum fibrinogen levels are positively correlated with advanced tumor stage and poor survival in patients with gastric cancer undergoing gastrectomy: a large cohort retrospective study

• Open Access
• Research article

Xuefeng Yu, Fulan Hu, Qiang Yao, Chunfeng Li, Hongfeng Zhang, Yingwei Xue

The Alberta Moving Beyond Breast Cancer (AMBER) Cohort Study: Recruitment, Baseline Assessment, and Description of the First 500 Participants

• Open Access
• Research article

Kerry S. Courneya, Margaret L. McNeely, S. Nicole Culos-Reed, Jeff K. Vallance, Gordon J. Bell, John R. Mackey, Charles E. Matthews, Andria R. Morielli, Diane Cook, Sarah MacLaughlin, Megan S. Farris, Stephanie Voaklander, Rachel O’Reilly, Christine M. Friedenreich

Etoposide damages female germ cells in the developing ovary

• Open Access
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Agnes Stefansdottir, Zoe C. Johnston, Nicola Powles-Glover, Richard A. Anderson, Ian R. Adams, Norah Spears

Osteopontin and thrombospondin-1 play opposite roles in promoting tumor aggressiveness of primary resected non-small cell lung cancer

• Open Access
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Mathieu Rouanne, Julien Adam, Aïcha Goubar, Angélique Robin, Caroline Ohana, Emilie Louvet, Jiemin Cormier, Olaf Mercier, Peter Dorfmüller, Soly Fattal, Vincent Thomas de Montpreville, Thierry Lebret, Philippe Dartevelle, Elie Fadel, Benjamin Besse, Ken André Olaussen, Christian Auclair, Jean-Charles Soria

Determining intrafractional prostate motion using four dimensional ultrasound system

• Open Access
• Research article

Mariwan Baker, Claus F. Behrens

Efficient generation of patient-matched malignant and normal primary cell cultures from clear cell renal cell carcinoma patients: clinically relevant models for research and personalized medicine

• Open Access
• Technical advance

Nazleen C. Lobo, Craig Gedye, Anthony J. Apostoli, Kevin R. Brown, Joshua Paterson, Natalie Stickle, Michael Robinette, Neil Fleshner, Robert J. Hamilton, Girish Kulkarni, Alexandre Zlotta, Andrew Evans, Antonio Finelli, Jason Moffat, Michael A. S. Jewett, Laurie Ailles

Subcellular differential expression of Ep-ICD in oral dysplasia and cancer is associated with disease progression and prognosis

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Raj Thani Somasundaram, Jatinder Kaur, Iona Leong, Christina MacMillan, Ian J. Witterick, Paul G. Walfish, Ranju Ralhan

Everolimus downregulates estrogen receptor and induces autophagy in aromatase inhibitor-resistant breast cancer cells

• Open Access
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Asona Lui, Jacob New, Joshua Ogony, Sufi Thomas, Joan Lewis-Wambi

Chronic kidney disease and the risk of cancer: an individual patient data meta-analysis of 32,057 participants from six prospective studies

• Open Access
• Research article

Germaine Wong, Natalie Staplin, Jonathan Emberson, Colin Baigent, Robin Turner, John Chalmers, Sophia Zoungas, Carol Pollock, Bruce Cooper, David Harris, Jie Jin. Wang, Paul Mitchell, Richard Prince, Wai Hon. Lim, Joshua Lewis, Jeremy Chapman, Jonathan Craig

MICAL1 controls cell invasive phenotype via regulating oxidative stress in breast cancer cells

• Open Access
• Research article

Wenjie Deng, Yueyuan Wang, Luo Gu, Biao Duan, Jie Cui, Yujie Zhang, Yan Chen, Shixiu Sun, Jing Dong, Jun Du

The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis

• Open Access
• Research article

Igor Snapkov, Carl Otto Öqvist, Yngve Figenschau, Per Kogner, John Inge Johnsen, Baldur Sveinbjørnsson

AT-101 enhances gefitinib sensitivity in non-small cell lung cancer with EGFR T790M mutations

• Open Access
• Research article

Ren Zhao, Shun Zhou, Bing Xia, Cui-ying Zhang, Ping Hai, Hong Zhe, Yan-yang Wang

Incorporating Yttrium-90 trans-arterial radioembolization (TARE) in the treatment of metastatic pancreatic adenocarcioma: a single center experience

• Open Access
• Research article

Alexander Y. Kim, Keith Unger, Hongkun Wang, Michael J. Pishvaian

Identification of V-ATPase as a molecular sensor of SOX11-levels and potential therapeutic target for mantle cell lymphoma

• Open Access
• Research article

Venera Kuci Emruli, Roger Olsson, Fredrik Ek, Sara Ek

Serum MMP7, MMP10 and MMP12 level as negative prognostic markers in colon cancer patients

• Open Access
• Research article

Fee Klupp, Lena Neumann, Christoph Kahlert, Johannes Diers, Niels Halama, Clemens Franz, Thomas Schmidt, Moritz Koch, Juergen Weitz, Martin Schneider, Alexis Ulrich

MicroRNA-183 suppresses cancer stem-like cell properties in EBV-associated nasopharyngeal carcinoma

• Open Access
• Research article

Chartia Ching-Mei Cheung, Samantha Wei-Man Lun, Grace Tin-Yun Chung, Chit Chow, Carman Lo, Kwong-Wai Choy, Kwok-Wai Lo

New anti-cancer chemicals Ertredin and its derivatives, regulate oxidative phosphorylation and glycolysis and suppress sphere formation in vitro and tumor growth in EGFRvIII-transformed cells

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• Research article

Sonoko Atsumi, Chisato Nosaka, Hayamitsu Adachi, Tomoyuki Kimura, Yoshihiko Kobayashi, Hisashi Takada, Takumi Watanabe, Shun-ichi Ohba, Hiroyuki Inoue, Manabu Kawada, Masakatsu Shibasaki, Masabumi Shibuya

Changes in mitochondrial stability during the progression of the Barrett’s esophagus disease sequence

• Open Access
• Research article

N. J. O’Farrell, R. Feighery, S. L. Picardo, N. Lynam-Lennon, M. Biniecka, S. A. McGarrigle, J. J. Phelan, F. MacCarthy, D. O’Toole, E. J. Fox, N. Ravi, J. V. Reynolds, J. O’Sullivan

Are preoperative histology and MRI useful for classification of endometrial cancer risk?

• Open Access
• Research article

Noemie Body, Vincent Lavoué, Olivier De Kerdaniel, Fabrice Foucher, Sébastien Henno, Aurélie Cauchois, Bruno Laviolle, Marc Leblanc, Jean Levêque

POSITIVE study: physical exercise program in non-operable lung cancer patients undergoing palliative treatment

• Open Access
• Study protocol

Joachim Wiskemann, Simone Hummler, Christina Diepold, Melanie Keil, Ulrich Abel, Karen Steindorf, Philipp Beckhove, Cornelia M. Ulrich, Martin Steins, Michael Thomas

Phase II study of metformin for reduction of obesity-associated breast cancer risk: a randomized controlled trial protocol

• Open Access
• Study protocol

Jessica A. Martinez, Pavani Chalasani, Cynthia A. Thomson, Denise Roe, Maria Altbach, Jean-Philippe Galons, Alison Stopeck, Patricia A. Thompson, Diana Evelyn Villa-Guillen, H-H. Sherry Chow

Combined chemoradiation of cisplatin versus carboplatin in cervical carcinoma: a single institution experience from Thailand

• Open Access
• Research article

Ekkasit Tharavichitkul, Vicharn Lorvidhaya, Pimkhuan Kamnerdsupaphon, Vimol Sukthomya, Somvilai Chakrabandhu, Pitchayaponne Klunklin, Wimrak Onchan, Bongkoch Supawongwattana, Nantaka Pukanhaphan, Razvan Galalae, Imjai Chitapanarux

Galectin-3 interacts with components of the nuclear ribonucleoprotein complex

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• Research article

Katharina Fritsch, Marco Mernberger, Andrea Nist, Thorsten Stiewe, Alexander Brehm, Ralf Jacob

ESOPEC: prospective randomized controlled multicenter phase III trial comparing perioperative chemotherapy (FLOT protocol) to neoadjuvant chemoradiation (CROSS protocol) in patients with adenocarcinoma of the esophagus (NCT02509286)

• Open Access
• Study protocol

Jens Hoeppner, Florian Lordick, Thomas Brunner, Torben Glatz, Peter Bronsert, Nadine Röthling, Claudia Schmoor, Dietmar Lorenz, Christian Ell, Ulrich T. Hopt, J. Rüdiger Siewert

CPA-7 influences immune profile and elicits anti-prostate cancer effects by inhibiting activated STAT3

• Open Access
• Research article

Meihua Liang, Fei Zhan, Juan Zhao, Qi Li, Jiazi Wuyang, Guannan Mu, Dianjun Li, Yanqiao Zhang, Xiaoyi Huang

Prognostic value of quality of life score in disease-free survivors of surgically-treated lung cancer

• Open Access
• Research article

Young Ho Yun, Young Ae Kim, Jin Ah Sim, Ae Sun Shin, Yoon Jung Chang, Jongmog Lee, Moon Soo Kim, Young Mog Shim, Jae lll Zo

Association of preoperative EpCAM Circulating Tumor Cells and peripheral Treg cell levels with early recurrence of hepatocellular carcinoma following radical hepatic resection

• Open Access
• Research article

Yan Zhou, Beili Wang, Jiong Wu, Chunyan Zhang, Yiwen Zhou, XinRong Yang, Jian Zhou, Wei Guo, Jia Fan

Occult invasive cervical cancer after simple hysterectomy: a multi-center retrospective study of 89 cases

• Open Access
• Research article

Huimin Bai, Dongyan Cao, Fang Yuan, Huilan Wang, Jie Chen, Yue Wang, Keng Shen, Zhenyu Zhang

ROR2 is epigenetically inactivated in the early stages of colorectal neoplasia and is associated with proliferation and migration

• Open Access
• Research article

Sean S. Q. Ma, Sameer Srivastava, Estelle Llamosas, Nicholas J. Hawkins, Luke B. Hesson, Robyn L. Ward, Caroline E. Ford

Y90 Radioembolization in chemo-refractory metastastic, liver dominant colorectal cancer patients: outcome assessment applying a predictive scoring system

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• Research article

Robert Damm, Ricarda Seidensticker, Gerhard Ulrich, Leonie Breier, Ingo G. Steffen, Max Seidensticker, Benjamin Garlipp, Konrad Mohnike, Maciej Pech, Holger Amthauer, Jens Ricke

Cross-reactivity profiles of hybrid capture II, cobas, and APTIMA human papillomavirus assays: split-sample study

• Open Access
• Research article

Sarah Preisler, Matejka Rebolj, Ditte Møller Ejegod, Elsebeth Lynge, Carsten Rygaard, Jesper Bonde

Prognostic significance of FOXM1 expression and antitumor effect of FOXM1 inhibition in synovial sarcomas

• Open Access
• Research article

Akira Maekawa, Kenichi Kohashi, Masaaki Kuda, Kunio Iura, Takeaki Ishii, Makoto Endo, Tetsuya Nakatsura, Yukihide Iwamoto, Yoshinao Oda

NRASQ61K mutated primary leptomeningeal melanoma in a child: case presentation and discussion on clinical and diagnostic implications

• Open Access
• Case report

Giulia Angelino, Maria Debora De Pasquale, Luigi De Sio, Annalisa Serra, Luca Massimi, Rita De Vito, Antonio Marrazzo, Laura Lancella, Andrea Carai, Manila Antonelli, Felice Giangaspero, Marco Gessi, Laura Menchini, Laura Scarciolla, Daniela Longo, Angela Mastronuzzi

A multi-centred randomised trial of radical surgery versus adjuvant chemoradiotherapy after local excision for early rectal cancer

• Open Access
• Study protocol

W. A. A. Borstlap, P. J. Tanis, T. W. A. Koedam, C. A. M. Marijnen, C. Cunningham, E. Dekker, M. E. van Leerdam, G. Meijer, N. van Grieken, I. D. Nagtegaal, C. J. A. Punt, M. G. W. Dijkgraaf, J. H. De Wilt, G. Beets, E. J. de Graaf, A. A. W van Geloven, M. F. Gerhards, H. L. van Westreenen, A. W. H. van de Ven, P. van Duijvendijk, I. H. J. T. de Hingh, J. W. A. Leijtens, C. Sietses, E. J. Spillenaar-Bilgen, R. J. C. L. M. Vuylsteke, C. Hoff, J. W. A. Burger, W. M. U. van Grevenstein, A. Pronk, R. J. I. Bosker, H. Prins, A. B. Smits, S. Bruin, D. D. Zimmerman, L. P. S. Stassen, M. S. Dunker, M. Westerterp, P. P. Coene, J. Stoot, W. A. Bemelman, J. B. Tuynman

CXCL12 expression promotes esophageal squamous cell carcinoma proliferation and worsens the prognosis

• Open Access
• Research article

Yusuke Uchi, Hiroya Takeuchi, Sachiko Matsuda, Yoshiro Saikawa, Hirofumi Kawakubo, Norihito Wada, Tsunehiro Takahashi, Rieko Nakamura, Kazumasa Fukuda, Tai Omori, Yuko Kitagawa

Prognostic impact of AJCC response criteria for neoadjuvant chemotherapy in stage II/III breast cancer patients: breast cancer subtype analyses

• Open Access
• Research article

Yaewon Yang, Seock-Ah Im, Bhumsuk Keam, Kyung‑Hun Lee, Tae‑Yong Kim, Koung Jin Suh, Han Suk Ryu, Hyeong-Gon Moon, Sae‑Won Han, Do‑Youn Oh, Wonshik Han, Tae‑You Kim, In Ae Park, Dong-Young Noh

High level of serum apolipoprotein A-I is a favorable prognostic factor for overall survival in esophageal squamous cell carcinoma

• Open Access
• Research article

Xue-Ping Wang, Xiao-Hui Li, Lin Zhang, Jian-Hua Lin, Hao Huang, Ting Kang, Min-Jie Mao, Hao Chen, Xin Zheng

A randomized cross-over trial to detect differences in arm volume after low- and heavy-load resistance exercise among patients receiving adjuvant chemotherapy for breast cancer at risk for arm lymphedema: study protocol

• Open Access
• Study protocol

Kira Bloomquist, Sandi Hayes, Lis Adamsen, Tom Møller, Karl Bach Christensen, Bent Ejlertsen, Peter Oturai

Erratum to: Survival, safety, and prognostic factors for outcome with Regorafenib in patients with metastatic colorectal cancer refractory to standard therapies: results from a multicenter study (REBECCA) nested within a compassionate use program

• Open Access
• Erratum

Antoine Adenis, Christelle de la Fouchardiere, Bernard Paule, Pascal Burtin, David Tougeron, Jennifer Wallet, Louis-Marie Dourthe, Pierre-Luc Etienne, Laurent Mineur, Stéphanie Clisant, Jean-Marc Phelip, Andrew Kramar, Thierry Andre

Predictive value of vrk 1 and 2 for rectal adenocarcinoma response to neoadjuvant chemoradiation therapy: a retrospective observational cohort study

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• Research article

Laura del Puerto-Nevado, Juan Pablo Marin-Arango, Maria Jesus Fernandez-Aceñero, David Arroyo-Manzano, Javier Martinez-Useros, Aurea Borrero-Palacios, Maria Rodriguez-Remirez, Arancha Cebrian, Teresa Gomez del Pulgar, Marlid Cruz-Ramos, Cristina Carames, Begoña Lopez-Botet, Jesús Garcia-Foncillas

The effectiveness of a nurse-led intervention with the distress thermometer for patients treated with curative intent for breast cancer: design of a randomized controlled trial

• Open Access
• Study protocol

Floortje K. Ploos van Amstel, Judith B. Prins, Winette T. A. van der Graaf, Marlies E. W. J. Peters, Petronella B. Ottevanger

p53-independent structure-activity relationships of 3-ring mesogenic compounds’ activity as cytotoxic effects against human non-small cell lung cancer lines

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Saori Fukushi, Hironori Yoshino, Atsushi Yoshizawa, Ikuo Kashiwakura

Comparison of the HER2, estrogen and progesterone receptor expression profile of primary tumor, metastases and circulating tumor cells in metastatic breast cancer patients

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Bahriye Aktas, Sabine Kasimir-Bauer, Volkmar Müller, Wolfgang Janni, Tanja Fehm, Diethelm Wallwiener, Klaus Pantel, Mitra Tewes

Is monitoring of plasma 5-fluorouracil levels in metastatic / advanced colorectal cancer clinically effective? A systematic review

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Karoline Freeman, Mark P. Saunders, Olalekan A. Uthman, Sian Taylor-Phillips, Martin Connock, Rachel Court, Tara Gurung, Paul Sutcliffe, Aileen Clarke

Utilizing native fluorescence imaging, modeling and simulation to examine pharmacokinetics and therapeutic regimen of a novel anticancer prodrug

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Jing-Hung Wang, Aaron N. Endsley, Carol E. Green, A. C. Matin

The combined expression of Semaphorin4D and PlexinB1 predicts disease recurrence in colorectal cancer

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Tetsuro Ikeya, Kiyoshi Maeda, Hisashi Nagahara, Masatsune Shibutani, Yasuhito Iseki, Kosei Hirakawa

Real-time HER2 status detected on circulating tumor cells predicts different outcomes of anti-HER2 therapy in histologically HER2-positive metastatic breast cancer patients

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Shaohua Zhang, Lei Li, Tao Wang, Li Bian, Haixu Hu, Chunhong Xu, Bing Liu, Yi Liu, Massimo Cristofanilli, Zefei Jiang

Study protocol of the CAREST-trial: a randomised controlled trial on the (cost-) effectiveness of a CBT-based online self-help training for fear of cancer recurrence in women with curatively treated breast cancer

• Open Access
• Study protocol

Sanne Jasperine van Helmondt, Marije Liesbeth van der Lee, Jolanda de Vries

Survival and prognostic factors in patients with stable and unstable spinal bone metastases from solid tumors: a retrospective analysis of 915 cases

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• Research article

Robert J. Wolf, Robert Foerster, Thomas Bruckner, Tilman Bostel, Ingmar Schlampp, Juergen Debus, Harald Rief, German Bone Research Group

A cohort analysis of men with a family history of BRCA1/2 and Lynch mutations for prostate cancer

• Open Access
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Lynne Kerr, Matthew J. Rewhorn, Mark Longmuir, Sioban Fraser, Shaun Walsh, Nicola Andrew, Hing Y. Leung

Foxp3 overexpression in tumor cells predicts poor survival in oral squamous cell carcinoma

• Open Access
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Jing-Jing Song, Si-Jia Zhao, Juan Fang, Da Ma, Xiang-Qi Liu, Xiao-Bing Chen, Yun Wang, Bin Cheng, Zhi Wang

Pro-survival responses to the dual inhibition of anti-apoptotic Bcl-2 family proteins and mTOR-mediated signaling in hypoxic colorectal carcinoma cells

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Karianne Risberg, Kathrine Røe Redalen, Linda Sønstevold, Tonje Bjørnetrø, Janne Sølvernes, Anne Hansen Ree

Saikosaponin d induces cell death through caspase-3-dependent, caspase-3-independent and mitochondrial pathways in mammalian hepatic stellate cells

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Ming-Feng Chen, S. Joseph Huang, Chao-Cheng Huang, Pei-Shan Liu, Kun-I Lin, Ching-Wen Liu, Wen-Chuan Hsieh, Li-Yen Shiu, Chang-Han Chen

Vascular disruptive agent OXi4503 and anti-angiogenic agent Sunitinib combination treatment prolong survival of mice with CRC liver metastasis

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Linh Nguyen, Theodora Fifis, Christopher Christophi

Pseudo-HE images derived from CARS/TPEF/SHG multimodal imaging in combination with Raman-spectroscopy as a pathological screening tool

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Thomas W. Bocklitz, Firas Subhi Salah, Nadine Vogler, Sandro Heuke, Olga Chernavskaia, Carsten Schmidt, Maximilian J. Waldner, Florian R. Greten, Rolf Bräuer, Michael Schmitt, Andreas Stallmach, Iver Petersen, Jürgen Popp

Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis

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Sandra Fernandes Martins, Ricardo Amorim, Marta Viana-Pereira, Céline Pinheiro, Ricardo Filipe Alves Costa, Patrícia Silva, Carla Couto, Sara Alves, Sara Fernandes, Sónia Vilaça, Joaquim Falcão, Herlander Marques, Fernando Pardal, Mesquita Rodrigues, Ana Preto, Rui Manuel Reis, Adhemar Longatto-Filho, Fátima Baltazar

Circulating proteins in response to combined-modality therapy in rectal cancer identified by antibody array screening

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Erta Kalanxhi, Helga Helseth Hektoen, Sebastian Meltzer, Svein Dueland, Kjersti Flatmark, Anne Hansen Ree

Rituximab plus chemotherapy as first-line treatment in Chinese patients with diffuse large B-cell lymphoma in routine practice: a prospective, multicentre, non-interventional study

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Jianqiu Wu, Yongping Song, Liping Su, Li Xu, Tingchao Chen, Zhiyun Zhao, Mingzhi Zhang, Wei Li, Yu Hu, Xiaohong Zhang, Yuhuan Gao, Zuoxing Niu, Ru Feng, Wei Wang, Jiewen Peng, Xiaolin Li, Xuenong Ouyang, Changping Wu, Weijing Zhang, Yun Zeng, Zhen Xiao, Yingmin Liang, Yongzhi Zhuang, Jishi Wang, Zimin Sun, Hai Bai, Tongjian Cui, Jifeng Feng

Atypical ubiquitin ligase RNF31: the nuclear factor modulator in breast cancer progression

• Open Access
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Jian Zhu, Ting Zhuang, Huijie Yang, Xin Li, Huandi Liu, Hui Wang

Transcriptome analysis of paired primary colorectal carcinoma and liver metastases reveals fusion transcripts and similar gene expression profiles in primary carcinoma and liver metastases

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Ja-Rang Lee, Chae Hwa Kwon, Yuri Choi, Hye Ji Park, Hyun Sung Kim, Hong-Jae Jo, Nahmgun Oh, Do Youn Park

PAC down-regulates estrogen receptor alpha and suppresses epithelial-to-mesenchymal transition in breast cancer cells

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Huda A. Al-Howail, Hana A. Hakami, Basem Al-Otaibi, Amer Al-Mazrou, Maha H. Daghestani, Ibrahim Al-Jammaz, Huda H. Al-Khalaf, Abdelilah Aboussekhra

The association of infrared imaging findings of the breast with prognosis in breast cancer patients: an observational cohort study

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Li-An Wu, Wen-Hung Kuo, Chin-Yu Chen, Yuh-Show Tsai, Jane Wang

Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed

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Boris Decarolis, Thorsten Simon, Barbara Krug, Ivo Leuschner, Christian Vokuhl, Peter Kaatsch, Dietrich von Schweinitz, Thomas Klingebiel, Ingo Mueller, Lothar Schweigerer, Frank Berthold, Barbara Hero

A case report: delayed high fever and maculopapules during Sorafenib treatment of ectopic hepatocellular carcinoma

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• Case report

Tianxiang Cui, Xinwei Diao, Xiewan Chen, Shaojiang Huang, Jianguo Sun

Effectiveness of work-related medical rehabilitation in cancer patients: study protocol of a cluster-randomized multicenter trial

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• Study protocol

Julian Wienert, Betje Schwarz, Matthias Bethge

Bifidobacterial recombinant thymidine kinase-ganciclovir gene therapy system induces FasL and TNFR2 mediated antitumor apoptosis in solid tumors

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Changdong Wang, Yongping Ma, Qiongwen Hu, Tingting Xie, Jiayan Wu, Fan Zeng, Fangzhou Song

Microsatellite alteration and immunohistochemical expression profile of chromosome 9p21 in patients with sporadic renal cell carcinoma following surgical resection

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Ismail El-Mokadem, Alison Lim, Thomas Kidd, Katherine Garret, Norman Pratt, David Batty, Stewart Fleming, Ghulam Nabi

Angiogenic cytokines and their influence on circulating tumour cells in sera of patients with the primary diagnosis of breast cancer before treatment

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Theresa Vilsmaier, Brigitte Rack, Wolfgang Janni, Udo Jeschke, Tobias Weissenbacher

Induction of artificial cancer stem cells from tongue cancer cells by defined reprogramming factors

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Koji Harada, Tarannum Ferdous, Dan Cui, Yasuhiro Kuramitsu, Takuya Matsumoto, Eiji Ikeda, Hideyuki Okano, Yoshiya Ueyama

Expression of circadian clock genes and proteins in urothelial cancer is related to cancer-associated genes

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Jorunn Litlekalsoy, Kari Rostad, Karl-Henning Kalland, Jens G. Hostmark, Ole Didrik Laerum

MK-2206 sensitizes BRCA-deficient epithelial ovarian adenocarcinoma to cisplatin and olaparib

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Margaret E. Whicker, Z. Ping Lin, Ruth Hanna, Alan C. Sartorelli, Elena S. Ratner

Palmitate-induced ER stress increases trastuzumab sensitivity in HER2/neu-positive breast cancer cells

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Jan Baumann, Jason Wong, Yan Sun, Douglas S. Conklin

A rare case of extremely high counts of circulating tumor cells detected in a patient with an oral squamous cell carcinoma

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• Case report

Xianglei Wu, Romina Mastronicola, Qian Tu, Gilbert Charles Faure, Marcelo De Carvalho Bittencourt, Gilles Dolivet

PIK3CA dependence and sensitivity to therapeutic targeting in urothelial carcinoma

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R. L. Ross, H. R. McPherson, L. Kettlewell, S. D. Shnyder, C. D. Hurst, O. Alder, M. A. Knowles

Better survival in right-sided versus left-sided stage I - III colon cancer patients

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Rene Warschkow, Michael C. Sulz, Lukas Marti, Ignazio Tarantino, Bruno M. Schmied, Thomas Cerny, Ulrich Güller

The effects of lymph node status on predicting outcome in ER+ /HER2- tamoxifen treated breast cancer patients using gene signatures

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Jessica G. Cockburn, Robin M. Hallett, Amy E. Gillgrass, Kay N. Dias, T. Whelan, M. N. Levine, John A. Hassell, Anita Bane

Pre-treatment MRI minimum apparent diffusion coefficient value is a potential prognostic imaging biomarker in cervical cancer patients treated with definitive chemoradiation

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Daniel Grossi Marconi, Jose Humberto Tavares Guerreiro Fregnani, Rodrigo Ribeiro Rossini, Ana Karina Borges Junqueira Netto, Fabiano Rubião Lucchesi, Audrey Tieko Tsunoda, Mitchell Kamrava

The impact of body mass index on treatment outcomes for patients with low-intermediate risk prostate cancer

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Kosj Yamoah, Charnita M. Zeigler-Johnson, Abra Jeffers, Bruce Malkowicz, Elaine Spangler, Jong Y. Park, Alice Whittemore, Timothy R. Rebbeck

Return to work after cancer treatment of gynecologic cancer in Japan

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Keiichiro Nakamura, Hisashi Masuyama, Takeshi Nishida, Junko Haraga, Naoyuki Ida, Masayuki Saijo, Tomoko Haruma, Tomoyuki Kusumoto, Noriko Seki, Yuji Hiramatsu

Increased sensitivity of African American triple negative breast cancer cells to nitric oxide-induced mitochondria-mediated apoptosis

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Luis Martinez, Easter Thames, Jinna Kim, Gautam Chaudhuri, Rajan Singh, Shehla Pervin

Single nucleotide polymorphism rs13042395 in the SLC52A3 gene as a biomarker for regional lymph node metastasis and relapse-free survival of esophageal squamous cell carcinoma patients

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Hua-Zhen Tan, Zhi-Yong Wu, Jian-Yi Wu, Lin Long, Ji-Wei Jiao, Yu-Hui Peng, Yi-Wei Xu, Shan-Shan Li, Wei Wang, Jian-Jun Zhang, En-Min Li, Li-Yan Xu

Heat shock protein 70–2 (HSP70-2) is a novel therapeutic target for colorectal cancer and is associated with tumor growth

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Nirmala Jagadish, Deepak Parashar, Namita Gupta, Sumit Agarwal, Vaishali Suri, Rajive Kumar, Vitusha Suri, Trilok Chand Sadasukhi, Anju Gupta, Abdul S. Ansari, Nirmal Kumar Lohiya, Anil Suri

Coffee consumption and the risk of malignant melanoma in the Norwegian Women and Cancer (NOWAC) Study

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Marko Lukic, Mie Jareid, Elisabete Weiderpass, Tonje Braaten

Primary extramammary invasive Paget’s vulvar disease: what is the standard, what are the challenges and what is the future for radiotherapy?

• Open Access
• Debate

Maria Tolia, Nikolaos Tsoukalas, Chrisostomos Sofoudis, Constantinos Giaginis, Despoina Spyropoulou, Dimitrios Kardamakis, Vasileios Kouloulias, George Kyrgias

The occurrence of hyponatremia and its importance as a prognostic factor in a cross-section of cancer patients

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Jorge J. Castillo, Ilya G. Glezerman, Susan H. Boklage, Joseph Chiodo III, Beni A. Tidwell, Lois E. Lamerato, Kathy L. Schulman

Collapsin response mediator protein 4 isoforms (CRMP4a and CRMP4b) have opposite effects on cell proliferation, migration, and invasion in gastric cancer

• Open Access
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Haijian Guo, Bing Xia

Mesenchymal stem cells enhance the metastasis of 3D-cultured hepatocellular carcinoma cells

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Chang Liu, Yang Liu, Xiao-xi Xu, Xin Guo, Guang-wei Sun, Xiao-jun Ma

Protein arginine methyltransferase 5 regulates multiple signaling pathways to promote lung cancer cell proliferation

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Xiumei Sheng, Zhengxin Wang

Post-crizotinib management of effective ceritinib therapy in a patient with ALK-positive non-small cell lung cancer

• Open Access
• Case report

Brian Won, Isa Mambetsariev, Ravi Salgia

Socio-economic deprivation: a significant determinant affecting stage of oral cancer diagnosis and survival

• Open Access
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Ajit Auluck, Blake Byron Walker, Greg Hislop, Scott A. Lear, Nadine Schuurman, Miriam Rosin

Overexpression of the miR-141/200c cluster promotes the migratory and invasive ability of triple-negative breast cancer cells through the activation of the FAK and PI3K/AKT signaling pathways by secreting VEGF-A

• Open Access
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Sul Ki Choi, Hoe Suk Kim, Tiefeng Jin, Eun Hye Hwang, Minji Jung, Woo Kyung Moon

CPP2-p16MIS treatment–induced colon carcinoma cell death in vitro and prolonged lifespan of tumor-bearing mice

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Lifeng Wang, Haijin Chen, Jinlong Yu, Xiaohua Lin, Jia Qi, Chunhui Cui, Lang Xie, Shuxin Huang

In chronic myeloid leukemia patients on second-line tyrosine kinase inhibitor therapy, deep sequencing of BCR-ABL1 at the time of warning may allow sensitive detection of emerging drug-resistant mutants

• Open Access
• Technical advance

Simona Soverini, Caterina De Benedittis, Fausto Castagnetti, Gabriele Gugliotta, Manuela Mancini, Luana Bavaro, Katerina Machova Polakova, Jana Linhartova, Alessandra Iurlo, Domenico Russo, Fabrizio Pane, Giuseppe Saglio, Gianantonio Rosti, Michele Cavo, Michele Baccarani, Giovanni Martinelli

A HELLP syndrome complicates a gestational trophoblastic neoplasia in a perimenopausal woman: a case report

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• Case report

Guillaume Vogin, François Golfier, Touria Hajri, Agnès Leroux, Béatrice Weber

The fibronectin III-1 domain activates a PI3-Kinase/Akt signaling pathway leading to αvβ5 integrin activation and TRAIL resistance in human lung cancer cells

• Open Access
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Christina Cho, Carol Horzempa, David Jones, Paula J. McKeown-Longo

CHEK2 represses breast stromal fibroblasts and their paracrine tumor-promoting effects through suppressing SDF-1 and IL-6

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Maha A. Al-Rakan, Siti-Faujiah Hendrayani, Abdelilah Aboussekhra

Reproducibility and uptake time dependency of volume-based parameters on FDG-PET for lung cancer

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Tomoka Kitao, Kenji Hirata, Katsumi Shima, Takashi Hayashi, Mitsunori Sekizawa, Toshiki Takei, Wataru Ichimura, Masao Harada, Keishi Kondo, Nagara Tamaki

A retrospective study of predictive factors for unexpectedly prolonged or shortened progression-free survival and overall survival among patients with metastatic renal cell carcinoma who received first-line targeted therapy

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Sung Han Kim, Sohee Kim, Jungnam Joo, Ho Kyung Seo, Jae Young Joung, Kang Hyun Lee, Jinsoo Chung

Emodin enhances cisplatin-induced cytotoxicity in human bladder cancer cells through ROS elevation and MRP1 downregulation

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Xinxing Li, Haolu Wang, Juan Wang, Yuying Chen, Xiaobin Yin, Guiying Shi, Hui Li, Zhiqian Hu, Xiaowen Liang

Health services research of integrative oncology in palliative care of patients with advanced pancreatic cancer

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Jan Axtner, Megan Steele, Matthias Kröz, Günther Spahn, Harald Matthes, Friedemann Schad

Effectiveness and cost-utility of a guided self-help exercise program for patients treated with total laryngectomy: protocol of a multi-center randomized controlled trial

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• Study protocol

Femke Jansen, Ingrid C. Cnossen, Simone E. J. Eerenstein, Veerle M. H. Coupé, Birgit I. Witte, Cornelia F. van Uden-Kraan, Patricia Doornaert, Weibel W. Braunius, Remco De Bree, José A. U. Hardillo, Jimmie Honings, György B. Halmos, C. René Leemans, Irma M. Verdonck-de Leeuw

Recapitulating epithelial tumor microenvironment in vitro using three dimensional tri-culture of human epithelial, endothelial, and mesenchymal cells

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Surya P. Lamichhane, Neha Arya, Esther Kohler, Shengnan Xiang, Jon Christensen, V. Prasad Shastri

Inhibition of nuclear factor-kappa B enhances the tumor growth of ovarian cancer cell line derived from a low-grade papillary serous carcinoma in p53-independent pathway

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Xue Xiao, Gong Yang, Peng Bai, Shunping Gui, Tri M. Bui Nyuyen, Imelda Mercado-Uribe, Mei Yang, Juan Zou, Qintong Li, Jianguo Xiao, Bin Chang, Guangzhi Liu, He Wang, Jinsong Liu

Long noncoding RNA TUG1 is downregulated in non-small cell lung cancer and can regulate CELF1 on binding to PRC2

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Pei-Chin Lin, Hsien-Da Huang, Chun-Chi Chang, Ya-Sian Chang, Ju-Chen Yen, Chien-Chih Lee, Wen-Hsin Chang, Ta-Chih Liu, Jan-Gowth Chang

Quantitative proteomic analysis for novel biomarkers of buccal squamous cell carcinoma arising in background of oral submucous fibrosis

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Wen Liu, Lijuan Zeng, Ning Li, Fei Wang, Canhua Jiang, Feng Guo, Xinqun Chen, Tong Su, Chunjiao Xu, Shanshan Zhang, Changyun Fang

A rational two-step approach to KRAS mutation testing in colorectal cancer using high resolution melting analysis and pyrosequencing

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Elisabeth Mack, Kathleen Stabla, Jorge Riera-Knorrenschild, Roland Moll, Andreas Neubauer, Cornelia Brendel

An exploration of men’s experiences of undergoing active surveillance for favourable-risk prostate cancer: A mixed methods study protocol

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• Study protocol

Eimear Ruane-McAteer, Joe O’Sullivan, Sam Porter, Lionne Venderbos, Gillian Prue

Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer

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Qing-Bai She, Sofia K. Gruvberger-Saal, Matthew Maurer, Yilun Chen, Mervi Jumppanen, Tao Su, Meaghan Dendy, Ying-Ka Ingar Lau, Lorenzo Memeo, Hugo M. Horlings, Marc J. van de Vijver, Jorma Isola, Hanina Hibshoosh, Neal Rosen, Ramon Parsons, Lao H. Saal

Radiation recall gastritis secondary to combination of gemcitabine and erlotinib in pancreatic cancer and response to PPI - a case report

• Open Access
• Case report

Seong Ji Choi, Hyo Jung Kim, Jae Seon Kim, Young-Tae Bak, Jun Suk Kim

Evaluation of folate receptor 1 (FOLR1) mRNA expression, its specific promoter methylation and global DNA hypomethylation in type I and type II ovarian cancers

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Sara Notaro, Daniel Reimer, Heidi Fiegl, Gabriel Schmid, Annamarie Wiedemair, Julia Rössler, Christian Marth, Alain Gustave Zeimet

“Safety and utility of percutaneous liver biopsy in hematopoietic stem cell transplant pediatric recipients: a retrospective study”

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Natalia Maximova, Massimo Gregori, Francesca Barbieri, Antonio Pizzol, Aurelio Sonzogni

Chemotherapy and radiation therapy elicits tumor specific T cell responses in a breast cancer patient

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David Bernal-Estévez, Ramiro Sánchez, Rafael E. Tejada, Carlos Parra-López

Pulmonary melanoma and “crazy paving” patterns in chest images: a case report and literature review

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• Case report

Yikuan Feng, Jianping Zhao, Qun Yang, Weining Xiong, Guohua Zhen, Yongjian Xu, Zhenxiang Zhang, Huilan Zhang

Case report: small cell transformation and metastasis to the breast in a patient with lung adenocarcinoma following maintenance treatment with epidermal growth factor receptor tyrosine kinase inhibitors

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• Case report

Quan Lin, Guo-ping Cai, Kai-Yan Yang, Li Yang, Cheng-Shui Chen, Yu-Ping Li

Casein kinase 1α has a non-redundant and dominant role within the CK1 family in melanoma progression

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Tobias Sinnberg, Jun Wang, Birgit Sauer, Birgit Schittek

Erratum to: Involvement of DNMT 3B promotes epithelial-mesenchymal transition and gene expression profile of invasive head and neck squamous cell carcinomas cell lines

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• Erratum

Li-Hsuen Chen, Wen-Lin Hsu, Yen-Ju Tseng, Dai-Wei Liu, Ching-Feng Weng

L1CAM as a prognostic marker in stage I endometrial cancer: a validation study

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• Research article

Elisabeth Smogeli, Ben Davidson, Milada Cvancarova, Arild Holth, Betina Katz, Bjørn Risberg, Gunnar Kristensen, Kristina Lindemann

Fibrillin-1 (FBN-1) a new marker of germ cell neoplasia in situ

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Z. Cierna, M. Mego, I. Jurisica, K. Machalekova, M. Chovanec, V. Miskovska, D. Svetlovska, K. Kalavska, K. Rejlekova, K. Kajo, J. Mardiak, P. Babal

Cost-effectiveness analysis of bortezomib in combination with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (VR-CAP) in patients with previously untreated mantle cell lymphoma

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Marjolijn van Keep, Kerry Gairy, Divyagiri Seshagiri, Pushpike Thilakarathne, Dawn Lee

Comparison of detection methods and follow-up study on the tyrosine kinase inhibitors therapy in non-small cell lung cancer patients with ROS1 fusion rearrangement

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Jieyu Wu, Yunen Lin, Xinming He, Haihong Yang, Ping He, Xinge Fu, Guangqiu Li, Xia Gu

Statin use and breast cancer survival: a nationwide cohort study in Scotland

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Úna C. Mc Menamin, Liam J. Murray, Carmel M. Hughes, Chris R. Cardwell

Efficacy of night-time compression for breast cancer related lymphedema (LYNC): protocol for a multi-centre, randomized controlled efficacy trial

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• Study protocol

Margaret L. McNeely, Kristin L. Campbell, Marc Webster, Urve Kuusk, Karen Tracey, John Mackey

S6Ks isoforms contribute to viability, migration, docetaxel resistance and tumor formation of prostate cancer cells

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Camila L. Amaral, Lidia B. Freitas, Rodrigo E. Tamura, Mariana R. Tavares, Isadora C. B. Pavan, Marcio C. Bajgelman, Fernando M. Simabuco

Inconsistent results in the analysis of ALK rearrangements in non-small cell lung cancer

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Johanna S. M. Mattsson, Hans Brunnström, Verena Jabs, Karolina Edlund, Karin Jirström, Stephanie Mindus, Linnéa la Fleur, Fredrik Pontén, Mats G. Karlsson, Christina Karlsson, Hirsh Koyi, Eva Brandén, Johan Botling, Gisela Helenius, Patrick Micke, Maria A. Svensson

A radiosensitizing effect of RAD51 inhibition in glioblastoma stem-like cells

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Anaïs Balbous, Ulrich Cortes, Karline Guilloteau, Pierre Rivet, Baptiste Pinel, Mathilde Duchesne, Julie Godet, Odile Boissonnade, Michel Wager, René Jean Bensadoun, Jean-Claude Chomel, Lucie Karayan-Tapon

MicroRNA-21 promotes proliferation, migration, and invasion of colorectal cancer, and tumor growth associated with down-regulation of sec23a expression

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Chenli Li, Lingxu Zhao, Yuan Chen, Tiantian He, Xiaowan Chen, Jiating Mao, Chunmei Li, Jianxin Lyu, Qing H. Meng

A nomogram for predicting pathological complete response in patients with human epidermal growth factor receptor 2 negative breast cancer

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Xi Jin, Yi-Zhou Jiang, Sheng Chen, Ke-Da Yu, Ding Ma, Wei Sun, Zhi-Min Shao, Gen-Hong Di

A retrospective analysis of Victorian and South Australian clinical registries for prostate cancer: trends in clinical presentation and management of the disease

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Rasa Ruseckaite, Kerri Beckmann, Michael O’Callaghan, David Roder, Kim Moretti, Jeremy Millar, Sue Evans

No inequalities in survival from colorectal cancer by education and socioeconomic deprivation - a population-based study in the North Region of Portugal, 2000-2002

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Luís Antunes, Denisa Mendonça, Maria José Bento, Bernard Rachet

Erratum to: Conformational changes and translocation of tissue-transglutaminase to the plasma membranes: role in cancer cell migration

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• Erratum

Ambrish Kumar, Jianjun Hu, Holly A. LaVoie, Kenneth B. Walsh, Donald J. DiPette, Ugra S. Singh

Erratum to: The anti-tumor effect of the quinoline-3-carboxamide tasquinimod: blockade of recruitment of CD11b+ Ly6Chi cells to tumor tissue reduces tumor growth

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• Erratum

Adnan Deronic, Sahar Tahvili, Tomas Leanderson, Fredrik Ivars

Imaging-genomics reveals driving pathways of MRI derived volumetric tumor phenotype features in Glioblastoma

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Patrick Grossmann, David A. Gutman, William D. Dunn Jr, Chad A. Holder, Hugo J. W. L. Aerts

Thresholds and timing of pre-operative thrombocytosis and ovarian cancer survival: analysis of laboratory measures from electronic medical records

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Gabriella D. Cozzi, Jacob M. Samuel, Jason T. Fromal, Spencer Keene, Marta A. Crispens, Dineo Khabele, Alicia Beeghly-Fadiel

Risk factors associated with early mortality in patients with multiple myeloma who were treated upfront with a novel agents containing regimen

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Sung-Hoon Jung, Min-Seok Cho, Hee Kyung Kim, Seok Jin Kim, Kihyun Kim, June-Won Cheong, Soo-Jeoong Kim, Jin Seok Kim, Jae-Sook Ahn, Yeo-Kyeoung Kim, Deok-Hwan Yang, Hyeoung-Joon Kim, Je-Jung Lee

Nanoroughened adhesion-based capture of circulating tumor cells with heterogeneous expression and metastatic characteristics

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Weiqiang Chen, Steven G. Allen, Ajaya Kumar Reka, Weiyi Qian, Shuo Han, Jianing Zhao, Liwei Bao, Venkateshwar G. Keshamouni, Sofia D. Merajver, Jianping Fu

uPAR enhances malignant potential of triple-negative breast cancer by directly interacting with uPA and IGF1R

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• Research article

Michaela C. Huber, Rebecca Mall, Herbert Braselmann, Annette Feuchtinger, Sara Molatore, Katrin Lindner, Axel Walch, Eva Gross, Manfred Schmitt, Natalie Falkenberg, Michaela Aubele

Pazolimus: pazopanib plus sirolimus following progression on pazopanib, a retrospective case series analysis

• Open Access
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D. Katz, Y. Azraq, F. Eleyan, S. Gill, T. Peretz, O. Merimsky

HDAC 1 and 6 modulate cell invasion and migration in clear cell renal cell carcinoma

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Swathi Ramakrishnan, ShengYu Ku, Eric Ciamporcero, Kiersten Marie Miles, Kris Attwood, Sreenivasulu Chintala, Li Shen, Leigh Ellis, Paula Sotomayor, Wendy Swetzig, Ray Huang, Dylan Conroy, Ashley Orillion, Gokul Das, Roberto Pili

Prognostic relevance of caspase 8 -652 6N InsDel and Asp302His polymorphisms for breast cancer

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J. D. Kuhlmann, A. Bankfalvi, K. W. Schmid, R. Callies, R. Kimmig, P. Wimberger, W. Siffert, H. S. Bachmann

Efficacy and safety of Dexrazoxane (DRZ) in sarcoma patients receiving high cumulative doses of anthracycline therapy – a retrospective study including 32 patients

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Markus K. Schuler, Sebastian Gerdes, Antje West, Stephan Richter, Christoph Busemann, Leopold Hentschel, Felicitas Lenz, Hans-Georg Kopp, Gerhard Ehninger, Peter Reichardt, Daniel Pink

Optimizing the process of fertility preservation in pediatric female cancer patients – a multidisciplinary program

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Irit Ben-Aharon, R. Abir, G. Perl, J. Stein, G. Gilad, H. Toledano, S. Elitzur, G. Avrahami, A. Ben-Haroush, G. Oron, E. Freud, D. Kravarusic, M. Ben-Arush, G. Herzel, I. Yaniv, S. M. Stemmer, B. Fisch, S. Ash

An evaluation in vitro of PARP-1 inhibitors, rucaparib and olaparib, as radiosensitisers for the treatment of neuroblastoma

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Donna L. Nile, Colin Rae, Iain J. Hyndman, Mark N. Gaze, Robert J. Mairs

AKT1 E17K mutation profiling in breast cancer: prevalence, concurrent oncogenic alterations, and blood-based detection

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Marion Rudolph, Tobias Anzeneder, Anke Schulz, Georg Beckmann, Annette T. Byrne, Michael Jeffers, Carol Pena, Oliver Politz, Karl Köchert, Richardus Vonk, Joachim Reischl

Metronomic cyclophosphamide activation of anti-tumor immunity: tumor model, mouse host, and drug schedule dependence of gene responses and their upstream regulators

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Junjie Wu, Marie Jordan, David J. Waxman

IAP antagonists Birinapant and AT-406 efficiently synergise with either TRAIL, BRAF, or BCL-2 inhibitors to sensitise BRAFV600E colorectal tumour cells to apoptosis

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Philippos Perimenis, Apostolos Galaris, Alexandra Voulgari, Margarita Prassa, Alexander Pintzas

Gd-EOB-DTPA-enhanced magnetic resonance imaging combined with T1 mapping predicts the degree of differentiation in hepatocellular carcinoma

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Zhenpeng Peng, Mengjie Jiang, Huasong Cai, Tao Chan, Zhi Dong, Yanji Luo, Zi-Ping Li, Shi-Ting Feng

Metabolic complete response with vinflunine as second-line therapy in a kidney-transplanted patient with advanced urothelial carcinoma: a case report

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• Case report

Paola Bordi, Marcello Tiseo, Giorgio Baldari, Sebastiano Buti

PNA clamping-assisted fluorescence melting curve analysis for detecting EGFR and KRAS mutations in the circulating tumor DNA of patients with advanced non-small cell lung cancer

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Ji-Youn Han, Jae-Jin Choi, Jin Young Kim, You Lim Han, Geon Kook Lee

Overexpression of KCNJ3 gene splice variants affects vital parameters of the malignant breast cancer cell line MCF-7 in an opposing manner

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S. Rezania, S. Kammerer, C. Li, B. Steinecker-Frohnwieser, A. Gorischek, T. T. J. DeVaney, S. Verheyen, C. A. Passegger, N. Ghaffari Tabrizi-Wizsy, H. Hackl, D. Platzer, A. H. Zarnani, E. Malle, S. W. Jahn, T. Bauernhofer, W. Schreibmayer

A germline mutation of CDKN2A and a novel RPLP1-C19MC fusion detected in a rare melanotic neuroectodermal tumor of infancy: a case report

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• Case report

David J. Barnes, Edward Hookway, Nick Athanasou, Takeshi Kashima, Udo Oppermann, Simon Hughes, Daniel Swan, Dietrich Lueerssen, John Anson, A. Bassim Hassan

Young patients and gastrointestinal (GI) tract malignancies - are we addressing the unmet needs?

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G. Perl, S. Nordheimer, S. Lando, C. Benedict, B. Brenner, S. Perry, G. Shmoisman, O. Purim, L. Amit, S. M. Stemmer, I. Ben-Aharon

Which is better for gastric cancer patients, perioperative or adjuvant chemotherapy: a meta-analysis

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Jun-hua Zhao, Peng Gao, Yong-xi Song, Jing-xu Sun, Xiao-wan Chen, Bin Ma, Yu-chong Yang, Zhen-ning Wang

Prognostic relevance of molecular subtypes and master regulators in pancreatic ductal adenocarcinoma

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Rekin’s Janky, Maria Mercedes Binda, Joke Allemeersch, Anke Van den broeck, Olivier Govaere, Johannes V. Swinnen, Tania Roskams, Stein Aerts, Baki Topal

Metformin use and its effect on survival in diabetic patients with advanced non-small cell lung cancer

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Oscar Arrieta, Edgar Varela-Santoyo, Enrique Soto-Perez-de-Celis, Roberto Sánchez-Reyes, Martha De la Torre-Vallejo, Saé Muñiz-Hernández, Andrés F. Cardona

A case report of a patient with metastatic ocular melanoma who experienced a response to treatment with the BRAF inhibitor vemurafenib

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• Case report

A. Maleka, G. Åström, P. Byström, G. J. Ullenhag

The usefulness of 18F-FDG PET/CT for assessing methotrexate-associated lymphoproliferative disorder (MTX-LPD)

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Shiro Watanabe, Osamu Manabe, Kenji Hirata, Noriko Oyama-Manabe, Naoya Hattori, Yasuka Kikuchi, Kentaro Kobayashi, Takuya Toyonaga, Nagara Tamaki

The deficiency of galectin-3 in stromal cells leads to enhanced tumor growth and bone marrow metastasis

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Jonathas Xavier Pereira, Maria Carolina Braga Azeredo, Felipe Sá Martins, Roger Chammas, Felipe Leite Oliveira, Sofia Nascimento Santos, Emerson Soares Bernardes, Márcia Cury El-Cheikh

Nurse-led group consultation intervention reduces depressive symptoms in men with localised prostate cancer: a cluster randomised controlled trial

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Penelope Schofield, Karla Gough, Kerryann Lotfi-Jam, Rebecca Bergin, Anna Ugalde, Paul Dudgeon, Wallace Crellin, Kathryn Schubach, Farshard Foroudi, Keen Hun Tai, Gillian Duchesne, Rob Sanson-Fisher, Sanchia Aranda

Characterization of VHL missense mutations in sporadic clear cell renal cell carcinoma: hotspots, affected binding domains, functional impact on pVHL and therapeutic relevance

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Caroline Razafinjatovo, Svenja Bihr, Axel Mischo, Ursula Vogl, Manuela Schmidinger, Holger Moch, Peter Schraml

MPO density in primary cancer biopsies of ovarian carcinoma enhances the indicative value of IL-17 for chemosensitivity

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Raoul A. Droeser, Robert Mechera, Silvio Däster, Benjamin Weixler, Marko Kraljević, Tarik Delko, Uwe Güth, Sylvia Stadlmann, Luigi Terracciano, Gad Singer

A phase I/II clinical trial for the hybrid of intracavitary and interstitial brachytherapy for locally advanced cervical cancer

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• Study protocol

Naoya Murakami, Shingo Kato, Takashi Nakano, Takashi Uno, Takeharu Yamanaka, Hideyuki Sakurai, Ryoichi Yoshimura, Junichi Hiratsuka, Yuki Kuroda, Kotaro Yoshio, Jun Itami

Heterogeneity of ERG expression in prostate cancer: a large section mapping study of entire prostatectomy specimens from 125 patients

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Maria-Christina Tsourlakis, Annegret Stender, Alexander Quaas, Martina Kluth, Corinna Wittmer, Alexander Haese, Markus Graefen, Stefan Steurer, Ronald Simon, Jan Korbel, Joachim Weischenfeldt, Hartwig Huland, Guido Sauter, Thorsten Schlomm, Sarah Minner

Type 2 diabetes mellitus and risk of colorectal adenoma: a meta-analysis of observational studies

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Feifei Yu, Yibin Guo, Hao Wang, Jian Feng, Zhichao Jin, Qi Chen, Yu Liu, Jia He

Cholesterol and prostate cancer risk: a long-term prospective cohort study

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Trond Heir, Ragnhild Sørum Falk, Trude Eid Robsahm, Leiv Sandvik, Jan Erikssen, Steinar Tretli

A phase 1 ‘window-of-opportunity’ trial testing evofosfamide (TH-302), a tumour-selective hypoxia-activated cytotoxic prodrug, with preoperative chemoradiotherapy in oesophageal adenocarcinoma patients

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• Study protocol

Ruben T. H. M. Larue, Lien Van De Voorde, Maaike Berbée, Wouter J. C. van Elmpt, Ludwig J. Dubois, Kranthi M. Panth, Sarah G. J. A. Peeters, Ann Claessens, Wendy M. J. Schreurs, Marius Nap, Fabiënne A. R. M. Warmerdam, Frans L. G. Erdkamp, Meindert N. Sosef, Philippe Lambin

Low dose DTIC is effective and safe in pretreated patients with well differentiated neuroendocrine tumors

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Daniela Mueller, Sebastian Krug, Moushumee Majumder, Anja Rinke, Thomas Matthias Gress

Shifting patterns of genomic variation in the somatic evolution of papillary thyroid carcinoma

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Jill C. Rubinstein, Taylor C. Brown, Emily R. Christison-Lagay, Yawei Zhang, John W. Kunstman, C. Christofer Juhlin, Carol Nelson-Williams, Gerald Goh, Courtney E. Quinn, Glenda G. Callender, Robert Udelsman, Richard P. Lifton, Reju Korah, Tobias Carling

Polo-like Kinase 1 as a potential therapeutic target in Diffuse Intrinsic Pontine Glioma

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Vladimir Amani, Eric W Prince, Irina Alimova, Ilango Balakrishnan, Diane Birks, Andrew M. Donson, Peter Harris, Jean M. Mulcahy Levy, Michael Handler, Nicholas K. Foreman, Sujatha Venkataraman, Rajeev Vibhakar

BCL9L expression in pancreatic neoplasia with a focus on SPN: a possible explanation for the enigma of the benign neoplasia

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Cora Hallas, Julia Phillipp, Lukas Domanowsky, Bettina Kah, Katharina Tiemann

p53, cathepsin D, Bcl-2 are joint prognostic indicators of breast cancer metastatic spreading

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Emanuela Guerra, Alessia Cimadamore, Pasquale Simeone, Giovanna Vacca, Rossano Lattanzio, Gerardo Botti, Valentina Gatta, Marco D’Aurora, Barbara Simionati, Mauro Piantelli, Saverio Alberti

Original article: role of adjuvant chemotherapy in a perioperative chemotherapy regimen for gastric cancer

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Sven Lichthardt, Alexander Kerscher, Ulrich A. Dietz, Christian Jurowich, Volker Kunzmann, Burkhard H. A. von Rahden, Christoph-Thomas Germer, Armin Wiegering

Five-year disease-free survival among stage II-IV breast cancer patients receiving FAC and AC chemotherapy in phase II clinical trials of Panagen

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Anastasia S. Proskurina, Tatiana S. Gvozdeva, Ekaterina A. Potter, Evgenia V. Dolgova, Konstantin E. Orishchenko, Valeriy P. Nikolin, Nelly A. Popova, Sergey V. Sidorov, Elena R. Chernykh, Alexandr A. Ostanin, Olga Y. Leplina, Victoria V. Dvornichenko, Dmitriy M. Ponomarenko, Galina S. Soldatova, Nikolay A. Varaksin, Tatiana G. Ryabicheva, Peter N. Uchakin, Vladimir A. Rogachev, Mikhail A. Shurdov, Sergey S. Bogachev

Connect MDS/AML: design of the myelodysplastic syndromes and acute myeloid leukemia disease registry, a prospective observational cohort study

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• Study protocol

David P. Steensma, Medrdad Abedi, Rafael Bejar, Christopher R. Cogle, Kathryn Foucar, Guillermo Garcia-Manero, Tracy I. George, David Grinblatt, Rami Komrokji, Xiaomei Ma, Jaroslaw Maciejewski, Daniel A. Pollyea, Michael R. Savona, Bart Scott, Mikkael A. Sekeres, Michael A. Thompson, Arlene S. Swern, Melissa Nifenecker, Mary M. Sugrue, Harry Erba

Prognostic value of HER2 status in bladder transitional cell carcinoma revealed by both IHC and BDISH techniques

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Taoufik Nedjadi, Jaudah Al-Maghrabi, Mourad Assidi, Ashraf Dallol, Heba Al-Kattabi, Adeel Chaudhary, Ahmed Al-Sayyad, Adel Al-Ammari, Adel Abuzenadah, Abdelbaset Buhmeida, Mohammed Al-Qahtani

Dynamic changes of tumor gene expression during repeated pressurized intraperitoneal aerosol chemotherapy (PIPAC) in women with peritoneal cancer

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Günther A. Rezniczek, Friederike Jüngst, Hendrik Jütte, Andrea Tannapfel, Ziad Hilal, Lukas A. Hefler, Marc-André Reymond, Clemens B. Tempfer

Increased long noncoding RNA SNHG20 predicts poor prognosis in colorectal cancer

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Cong Li, Li Zhou, Jun He, Xue-Qing Fang, Shao-Wen Zhu, Mao-Ming Xiong

Pembrolizumab-associated minimal change disease in a patient with malignant pleural mesothelioma

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• Case report

Angelika Bickel, Irene Koneth, Annette Enzler-Tschudy, Jörg Neuweiler, Lukas Flatz, Martin Früh

Dactolisib (NVP-BEZ235) toxicity in murine brain tumour models

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I. A. Netland, H. E. Førde, L. Sleire, L. Leiss, M. A. Rahman, B. S. Skeie, C. H. Gjerde, P. Ø. Enger, D. Goplen

Nomograms to predict survival after colorectal cancer resection without preoperative therapy

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Zhen-yu Zhang, Qi-feng Luo, Xiao-wei Yin, Zhen-ling Dai, Shiva Basnet, Hai-yan Ge

Oligo-recurrence predicts favorable prognosis of brain-only oligometastases in patients with non-small cell lung cancer treated with stereotactic radiosurgery or stereotactic radiotherapy: a multi-institutional study of 61 subjects

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Yuzuru Niibe, Tetsuo Nishimura, Tetsuya Inoue, Katsuyuki Karasawa, Yoshiyuki Shioyama, Keiichi Jingu, Hiroki Shirato

Use of non-steroidal anti-inflammatory drugs and risk of breast cancer: The Spanish Multi-Case-control (MCC) study

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Trinidad Dierssen-Sotos, Inés Gómez-Acebo, María de Pedro, Beatriz Pérez-Gómez, Sonia Servitja, Víctor Moreno, Pilar Amiano, Tania Fernandez-Villa, Aurelio Barricarte, Adonina Tardon, Marian Diaz-Santos, Rosana Peiro-Perez, Rafael Marcos-Gragera, Virginia Lope, Esther Gracia-Lavedan, M. Henar Alonso, Maria Jesus Michelena-Echeveste, Andrés Garcia-Palomo, Marcela Guevara, Gemma Castaño-Vinyals, Nuria Aragonés, Manolis Kogevinas, Marina Pollán, Javier Llorca

Is there any role of intravenous iron for the treatment of anemia in cancer?

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Cengiz Gemici, Ozlem Yetmen, Gokhan Yaprak, Sevgi Ozden, Huseyin Tepetam, Hazan Ozyurt, Alpaslan Mayadagli

Environmental, maternal, and reproductive risk factors for childhood acute lymphoblastic leukemia in Egypt: a case-control study

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Sameera Ezzat, Wafaa M. Rashed, Sherin Salem, M. Tevfik Dorak, Mai El-Daly, Mohamed Abdel-Hamid, Iman Sidhom, Alaa El-Hadad, Christopher Loffredo

SPARC expression in patients with high-risk localized soft tissue sarcoma treated on a randomized phase II trial of neo/adjuvant chemotherapy

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Elizabeth J. Davis, Lili Zhao, David R. Lucas, Scott M. Schuetze, Laurence H. Baker, Mark M. Zalupski, Dafydd Thomas, Rashmi Chugh

Effect of diagnostic delay on survival in patients with colorectal cancer: a retrospective cohort study

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Salvador Pita-Fernández, Luis González-Sáez, Beatriz López-Calviño, Teresa Seoane-Pillado, Elena Rodríguez-Camacho, Alejandro Pazos-Sierra, Paloma González-Santamaría, Sonia Pértega-Díaz

Interleukin 12 shows a better curative effect on lung cancer than paclitaxel and cisplatin doublet chemotherapy

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Ting Yue, Xiaodong Zheng, Yaling Dou, Xiaohu Zheng, Rui Sun, Zhigang Tian, Haiming Wei

Antemortem diagnosis of pulmonary tumor thrombotic microangiopathy in a patient with recurrent breast cancer: a case report

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• Case report

Yui Takahashi, Hironori Uruga, Takeshi Fujii, Sayaka Mochizuki, Shigeo Hanada, Hisashi Takaya, Atsushi Miyamoto, Nasa Morokawa, Atsuko Kurosaki, Kazuma Kishi

Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity

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María Díaz-Núñez, Alejandro Díez-Torre, Olivier De Wever, Ricardo Andrade, Jon Arluzea, Margarita Silió, Juan Aréchaga

Performance and prognostic utility of the 92-gene assay in the molecular subclassification of ampullary adenocarcinoma

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Michael J. Overman, Harris S. Soifer, Aaron Joel Schueneman, Joe Ensor Jr, Volkan Adsay, Burcu Saka, Nastaran Neishaboori, Robert A. Wolff, Huamin Wang, Catherine A. Schnabel, Gauri Varadhachary

Expression of EIF5A2 associates with poor survival of nasopharyngeal carcinoma patients treated with induction chemotherapy

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Pei-Yu Huang, Ting-Ting Zeng, Xiaojiao Ban, Meng-Qing Li, Bao-Zhu Zhang, Ying-Hui Zhu, Wen-Feng Hua, Hai-Qiang Mai, Li Zhang, Xin-Yuan Guan, Yan Li

BRCA1-associated protein 1 deficiency in lung adenocarcinoma predicts poor outcome and increased tumor invasion

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Chen Shen, Yiqin Wang, Ping Wei, Xiang Du

The transcriptional regulator TBX3 promotes progression from non-invasive to invasive breast cancer

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Milica Krstic, Connor D. Macmillan, Hon S. Leong, Allen G. Clifford, Lesley H. Souter, David W. Dales, Carl O. Postenka, Ann F. Chambers, Alan B. Tuck

Predicting clinical outcomes in chordoma patients receiving immunotherapy: a comparison between volumetric segmentation and RECIST

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Kathleen E. Fenerty, Les R. Folio, Nicholas J. Patronas, Jennifer L. Marté, James L. Gulley, Christopher R. Heery

High prevalence and predominance of BRCA1 germline mutations in Pakistani triple-negative breast cancer patients

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Muhammad Usman Rashid, Noor Muhammad, Seerat Bajwa, Saima Faisal, Muhammad Tahseen, Justo Lorenzo Bermejo, Asim Amin, Asif Loya, Ute Hamann

Role of vitamin D receptor gene Cdx2 and Apa1 polymorphisms in prostate cancer susceptibility: a meta-analysis

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Kewei Wang, Guosheng Wu, Jinping Li, Wentao Song

Outcomes of uterine sarcoma found incidentally after uterus-preserving surgery for presumed benign disease

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Jung-Yun Lee, Hyun Soo Kim, Eun Ji Nam, Sang Wun Kim, Sunghoon Kim, Young Tae Kim

Identification of SEC62 as a potential marker for 3q amplification and cellular migration in dysplastic cervical lesions

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Maximilian Linxweiler, Florian Bochen, Bernhard Schick, Silke Wemmert, Basel Al Kadah, Markus Greiner, Andrea Hasenfus, Rainer-Maria Bohle, Ingolf Juhasz-Böss, Erich-Franz Solomayer, Zoltan Ferenc Takacs

Efficacy and safety of bevacizumab plus chemotherapy compared to chemotherapy alone in previously untreated advanced or metastatic colorectal cancer: a systematic review and meta-analysis

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Tobias Engel Ayer Botrel, Luciana Gontijo de Oliveira Clark, Luciano Paladini, Otávio Augusto C. Clark

Identification of therapeutic targets applicable to clinical strategies in ovarian cancer

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Marianne K. Kim, Natasha Caplen, Sirisha Chakka, Lidia Hernandez, Carrie House, Georgios Pongas, Elizabeth Jordan, Christina M. Annunziata

Auto-immune thyroid dysfunction induced by tyrosine kinase inhibitors in a patient with recurrent chordoma

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• Case report

Juliette Eroukhmanoff, Frederic Castinetti, Nicolas Penel, Sebastien Salas

Systems-level effects of ectopic galectin-7 reconstitution in cervical cancer and its microenvironment

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Juan Carlos Higareda-Almaraz, Juan S. Ruiz-Moreno, Jana Klimentova, Daniela Barbieri, Raquel Salvador-Gallego, Regina Ly, Ilse A. Valtierra-Gutierrez, Christiane Dinsart, Gabriel A. Rabinovich, Jiri Stulik, Frank Rösl, Bladimiro Rincon-Orozco

Clinicopathological implications of Tiam1 overexpression in invasive ductal carcinoma of the breast

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Zhenling Li, Qixiang Liu, Junjie Piao, Fenjian Hua, Jing Wang, Guang Jin, Zhenhua Lin, Yan Zhang

The insulin-like growth factor system is modulated by exercise in breast cancer survivors: a systematic review and meta-analysis

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José Francisco Meneses-Echávez, Emilio González Jiménez, Jacqueline Schmidt Río-Valle, Jorge Enrique Correa-Bautista, Mikel Izquierdo, Robinson Ramírez-Vélez

High sensitivity isoelectric focusing to establish a signaling biomarker for the diagnosis of human colorectal cancer

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Narendra Padhan, Torbjörn E. M. Nordling, Magnus Sundström, Peter Åkerud, Helgi Birgisson, Peter Nygren, Sven Nelander, Lena Claesson-Welsh

Dermatomyositis with anti-TIF-1γ antibodies as a presenting symptom of underlying triple-negative breast cancer: a case report

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• Case report

Ondřej Kubeček, Tomáš Soukup, Adam Paulík, Jindřich Kopecký

MicroRNA-21 regulates prostaglandin E2 signaling pathway by targeting 15-hydroxyprostaglandin dehydrogenase in tongue squamous cell carcinoma

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Qianting He, Zujian Chen, Qian Dong, Leitao Zhang, Dan Chen, Aditi Patel, Ajay Koya, Xianghong Luan, Robert J. Cabay, Yang Dai, Anxun Wang, Xiaofeng Zhou

Tailored Beta-catenin mutational approach in extra-abdominal sporadic desmoid tumor patients without therapeutic intervention

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• Study protocol

Danique L.M. van Broekhoven, Dirk J. Grünhagenl, Thijs van Dalen, Frits van Coevorden, Han J. Bonenkamp, Lukas B. Been, Marc H.A. Bemelmans, Sander D.S. Dijkstra, Chiara Colombo, Alessandro Gronchi, Cornelis Verhoef

Worse outcome in breast cancer with higher tumor-infiltrating FOXP3+ Tregs : a systematic review and meta-analysis

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Jiafeng Shou, Zhigang Zhang, Yucheng Lai, Zhigang Chen, Jian Huang

Changes in the in vitro activity of platinum drugs when administered in two aliquots

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Zaynab Al-Eisawi, Philip Beale, Charles Chan, Jun Qing Yu, Nicholas Proschogo, Mark Molloy, Fazlul Huq

Survival, recurrence and toxicity of HNSCC in comparison of a radiotherapy combination with cisplatin versus cetuximab: a meta-analysis

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Jingwen Huang, Jing Zhang, Changle Shi, Lei Liu, Yuquan Wei

Belotecan/cisplatin versus etoposide/cisplatin in previously untreated patients with extensive-stage small cell lung carcinoma: a multi-center randomized phase III trial

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In-Jae Oh, Kyu-Sik Kim, Cheol-Kyu Park, Young-Chul Kim, Kwan-Ho Lee, Jin-Hong Jeong, Sun-Young Kim, Jeong-Eun Lee, Kye-Chul Shin, Tae-Won Jang, Hyun-Kyung Lee, Kye-Young Lee, Sung-Yong Lee

Racial differences in six major subtypes of melanoma: descriptive epidemiology

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Yu Wang, Yinjun Zhao, Shuangge Ma

Performance comparison of two commercial human whole-exome capture systems on formalin-fixed paraffin-embedded lung adenocarcinoma samples

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Silvia Bonfiglio, Irene Vanni, Valeria Rossella, Anna Truini, Dejan Lazarevic, Maria Giovanna Dal Bello, Angela Alama, Marco Mora, Erika Rijavec, Carlo Genova, Davide Cittaro, Francesco Grossi, Simona Coco

Induction Chemotherapy Followed by Radiotherapy versus Concurrent Chemoradiotherapy in elderly patients with nasopharyngeal carcinoma: finding from a propensity-matched analysis

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Qi Zeng, Jie Wang, Xing Lv, Jie Li, Li-Jie Yin, Yan-Qun Xiang, Xiang Guo

Advanced MRI manifestations of trigeminal ganglioneuroma: a case report and literature review

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• Case report

Xiaojuan Deng, Jingqin Fang, Qingya Luo, Haipeng Tong, Weiguo Zhang

MET and PTEN gene copy numbers and Ki-67 protein expression associate with pathologic complete response in ERBB2-positive breast carcinoma patients treated with neoadjuvant trastuzumab-based therapy

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• Research article

Benjamin C. Calhoun, Bryce Portier, Zhen Wang, Eugen C. Minca, G. Thomas Budd, Christopher Lanigan, Raymond R. Tubbs, Larry E. Morrison

Validation of the flemish CARES, a quality of life and needs assessment tool for cancer care

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Bojoura Schouten, Johan Hellings, Elke Van Hoof, Patrick Vankrunkelsven, Paul Bulens, Frank Buntinx, Jeroen Mebis, Dominique Vandijck, Ward Schrooten

Decreased expression of stomatin predicts poor prognosis in HER2-positive breast cancer

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• Research article

Chin-Yau Chen, Chih-Yung Yang, Yen-Chung Chen, Chia-Wen Shih, Su-Shun Lo, Chi-Hung Lin

Effectiveness of a multimodal standard nursing program on health-related quality of life in Chinese mainland female patients with breast cancer: protocol for a single-blind cluster randomized controlled trial

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• Study protocol

Kaina Zhou, Duolao Wang, Xiaole He, Lanting Huo, Jinghua An, Minjie Li, Wen Wang, Xiaomei Li

Sunitinib added to FOLFIRI versus FOLFIRI in patients with chemorefractory advanced adenocarcinoma of the stomach or lower esophagus: a randomized, placebo-controlled phase II AIO trial with serum biomarker program

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Markus Moehler, Irina Gepfner-Tuma, Annett Maderer, Peter C. Thuss-Patience, Joern Ruessel, Susanna Hegewisch-Becker, Hansjochen Wilke, Salah-Eddin Al-Batran, Mohammad-Reza Rafiyan, Florian Weißinger, Hans-Joachim Schmoll, Frank Kullmann, Ludwig Fischer von Weikersthal, Jens T. Siveke, Jens Weusmann, Stephan Kanzler, Carl Christoph Schimanski, Melanie Otte, Lukas Schollenberger, Jochem Koenig, Peter R. Galle

Identification of epigenetic factors regulating the mesenchyme to epithelium transition by RNA interference screening in breast cancer cells

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Jean-Marc Gregoire, Laurence Fleury, Clara Salazar-Cardozo, Frédéric Alby, Véronique Masson, Paola Barbara Arimondo, Frédéric Ausseil

Anti-cancer effect of pristimerin by inhibition of HIF-1α involves the SPHK-1 pathway in hypoxic prostate cancer cells

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Seon-Ok Lee, Joo-Seok Kim, Myoung-Sun Lee, Hyo-Jeong Lee

Deferasirox, a novel oral iron chelator, shows antiproliferative activity against pancreatic cancer in vitro and in vivo

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Hirofumi Harima, Seiji Kaino, Taro Takami, Shuhei Shinoda, Toshihiko Matsumoto, Koichi Fujisawa, Naoki Yamamoto, Takahiro Yamasaki, Isao Sakaida

Continual reassessment method for dose escalation clinical trials in oncology: a comparison of prior skeleton approaches using AZD3514 data

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Gareth D. James, Stefan N. Symeonides, Jayne Marshall, Julia Young, Glen Clack

Promoter hypermethylation of HS3ST2, SEPTIN9 and SLIT2 combined with FGFR3 mutations as a sensitive/specific urinary assay for diagnosis and surveillance in patients with low or high-risk non-muscle-invasive bladder cancer

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Jean-Pierre Roperch, Bernard Grandchamp, François Desgrandchamps, Pierre Mongiat-Artus, Vincent Ravery, Idir Ouzaid, Morgan Roupret, Véronique Phe, Calin Ciofu, Florence Tubach, Olivier Cussenot, Roberto Incitti

Advanced hepatocellular carcinoma with hepatic vein tumor thrombosis and renal dysfunction after hepatic arterial infusion chemotherapy effectively treated by liver resection with active veno-venous bypass: report of a case

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• Case report

Atene Itoh, Hiroshi Sadamori, Kazuhisa Yabushita, Kazuteru Monden, Masashi Tatsukawa, Masayoshi Hioki, Tsuyoshi Hyodo, Kunihiro Omonishi, Toru Ueki, Satoshi Ohno, Kohsaku Sakaguchi, Norihisa Takakura

Long non-coding RNA MALAT-1 modulates metastatic potential of tongue squamous cell carcinomas partially through the regulation of small proline rich proteins

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Zhengyu Fang, Shanshan Zhang, Yufan Wang, Shiyue Shen, Feng Wang, Yinghua Hao, Yuxia Li, Bingyue Zhang, You Zhou, Hongyu Yang

Anti-cancer effects of baicalein in non-small cell lung cancer in-vitro and in-vivo

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Mary-Clare Cathcart, Zivile Useckaite, Clive Drakeford, Vikki Semik, Joanne Lysaght, Kathy Gately, Kenneth J. O’Byrne, Graham P. Pidgeon

A comparative study on the efficacies of gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist in neoadjuvant androgen deprivation therapy combined with transperineal prostate brachytherapy for localized prostate cancer

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• Study protocol

Kenta Miki, Hiroshi Sasaki, Masahito Kido, Hiroyuki Takahashi, Manabu Aoki, Shin Egawa

NAB-paclitaxel and gemcitabine in metastatic pancreatic ductal adenocarcinoma (PDAC): from clinical trials to clinical practice

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Ferdinando De Vita, Jole Ventriglia, Antonio Febbraro, Maria Maddalena Laterza, Alessio Fabozzi, Beatrice Savastano, Angelica Petrillo, Anna Diana, Guido Giordano, Teresa Troiani, Giovanni Conzo, Gennaro Galizia, Fortunato Ciardiello, Michele Orditura

The effect of neoadjuvant chemotherapy and chemoradiotherapy on exercise capacity and outcome following upper gastrointestinal cancer surgery: an observational cohort study

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• Study protocol

M. A. West, L. Loughney, G. Ambler, B. D. Dimitrov, J. J. Kelly, M. G. Mythen, R. Sturgess, P. M. A. Calverley, A. Kendrick, M. P. W. Grocott, S. Jack

Piloting a generic cancer consumer quality index in six European countries

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Anke Wind, Mark Patrick Roeling, Jana Heerink, Herman Sixma, Pietro Presti, Claudio Lombardo, Wim van Harten

Cost-effectiveness and resource use of implementing MRI-guided NACT in ER-positive/HER2-negative breast cancers in The Netherlands

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Anna Miquel-Cases, Lotte M. G. Steuten, Lisanne S. Rigter, Wim H. van Harten

CD44 and RHAMM are essential for rapid growth of bladder cancer driven by loss of Glycogen Debranching Enzyme (AGL)

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Darby Oldenburg, Yuanbin Ru, Benjamin Weinhaus, Steve Cash, Dan Theodorescu, Sunny Guin

Clinically suspected T4 colorectal cancer may be resected using a laparoscopic approach

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Jong Seob Park, Jung Wook Huh, Yoon Ah Park, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee, Ho-Kyung Chun

Race/ethnicity and socio-economic differences in colorectal cancer surgery outcomes: analysis of the nationwide inpatient sample

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Tomi Akinyemiju, Qingrui Meng, Neomi Vin-Raviv

Expression of AE1/p16 promoted degradation of AE2 in gastric cancer cells

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Ting Wang, Hong-Jun Fei, Ye Yang, Xiao-Shu Jiang, Min Yan, Zhi Zeng, Jun Wu, Ling-Jun Song, Hua Tian, Guo-Hui Fu

Overexpression of synuclein-γ predicts lack of benefit from radiotherapy for breast cancer patients

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Li Min, Cheng Zhang, Ruolan Ma, Xiaofan Li, Hua Yuan, Yihao Li, Ruxuan Chen, Caiyun Liu, Jianping Guo, Like Qu, Chengchao Shou

Malignant mesothelioma of the pleura with desmoplastic histology: a case series and literature review

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Kana Hashimoto, Yusuke Okuma, Yukio Hosomi, Tsunekazu Hishima

Genome-wide analyses of long noncoding RNA expression profiles correlated with radioresistance in nasopharyngeal carcinoma via next-generation deep sequencing

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Guo Li, Yong Liu, Chao Liu, Zhongwu Su, Shuling Ren, Yunyun Wang, Tengbo Deng, Donghai Huang, Yongquan Tian, Yuanzheng Qiu

Protocol for a mixed methods longitudinal enquiry into the impact of a community based supportive service for people affected by cancer

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Austyn Snowden, Jenny Young, Mick Fleming

The combination of serum insulin, osteopontin, and hepatocyte growth factor predicts time to castration-resistant progression in androgen dependent metastatic prostate cancer- an exploratory study

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Farshid Dayyani, Amado J. Zurita, Graciela M. Nogueras-González, Rebecca Slack, Randall E. Millikan, John C. Araujo, Gary E. Gallick, Christopher J. Logothetis, Paul G. Corn

The pretreatment Controlling Nutritional Status (CONUT) score is an independent prognostic factor in patients with resectable thoracic esophageal squamous cell carcinoma: results from a retrospective study

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Takahiro Toyokawa, Naoshi Kubo, Tatsuro Tamura, Katsunobu Sakurai, Ryosuke Amano, Hiroaki Tanaka, Kazuya Muguruma, Masakazu Yashiro, Kosei Hirakawa, Masaichi Ohira

In vivo bioluminescence imaging for leptomeningeal dissemination of medulloblastoma in mouse models

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Seung Ah Choi, Pil Ae Kwak, Seung-Ki Kim, Sung-Hye Park, Ji Yeoun Lee, Kyu-Chang Wang, Hyun Jeong Oh, Kyuwan Kim, Dong Soo Lee, Do Won Hwang, Ji Hoon Phi

IL-1β induces IL-6 production and increases invasiveness and estrogen-independent growth in a TG2-dependent manner in human breast cancer cells

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Keunhee Oh, Ok-Young Lee, Yeonju Park, Myung Won Seo, Dong-Sup Lee

53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells

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Ruoxi Hong, Fei Ma, Weimin Zhang, Xiying Yu, Qing Li, Yang Luo, Changjun Zhu, Wei Jiang, Binghe Xu

Iterative sorting reveals CD133+ and CD133- melanoma cells as phenotypically distinct populations

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Carole Grasso, Matthew Anaka, Oliver Hofmann, Ramakrishna Sompallae, Kate Broadley, Winston Hide, Michael V. Berridge, Jonathan Cebon, Andreas Behren, Melanie J. McConnell

Place of death in children and young people with cancer and implications for end of life care: a population-based study in England, 1993–2014

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Wei Gao, Julia Verne, Janet Peacock, Charles Stiller, Claudia Wells, Anne Greenough, Irene J. Higginson

A phase-I trial of pre‐operative, margin intensive, stereotactic body radiation therapy for pancreatic cancer: the ‘SPARC’ trial protocol

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• Study protocol

Daniel L. P. Holyoake, Elizabeth Ward, Derek Grose, David McIntosh, David Sebag-Montefiore, Ganesh Radhakrishna, Neel Patel, Michael Silva, Somnath Mukherjee, Victoria Y. Strauss, Lang’o Odondi, Emmanouil Fokas, Alan Melcher, Maria A. Hawkins

Lung adenocarcinoma mimicking pulmonary fibrosis-a case report

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• Case report

Bakir Mehić, Lina Duranović Rayan, Nurija Bilalović, Danina Dohranović Tafro, Ilijaz Pilav

Favorable prognosis in colorectal cancer patients with co-expression of c-MYC and ß-catenin

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Kyu Sang Lee, Yoonjin Kwak, Kyung Han Nam, Duck-Woo Kim, Sung-Bum Kang, Gheeyoung Choe, Woo Ho Kim, Hye Seung Lee

Does native Trypanosoma cruzi calreticulin mediate growth inhibition of a mammary tumor during infection?

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Paula Abello-Cáceres, Javier Pizarro-Bauerle, Carlos Rosas, Ismael Maldonado, Lorena Aguilar-Guzmán, Carlos González, Galia Ramírez, Jorge Ferreira, Arturo Ferreira

microRNA-mediated resistance to hypoglycemia in the HepG2 human hepatoma cell line

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Satomi Ueki, Yuko Murakami, Shoji Yamada, Masaki Kimura, Yoshimasa Saito, Hidetsugu Saito

Rationale and design of the multidisciplinary team IntervenTion in cArdio-oNcology study (TITAN)

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Edith Pituskin, Mark Haykowsky, Margaret McNeely, John Mackey, Neil Chua, Ian Paterson

Prognosis of breast cancer molecular subtypes in routine clinical care: A large prospective cohort study

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André Hennigs, Fabian Riedel, Adam Gondos, Peter Sinn, Peter Schirmacher, Frederik Marmé, Dirk Jäger, Hans-Ulrich Kauczor, Anne Stieber, Katja Lindel, Jürgen Debus, Michael Golatta, Florian Schütz, Christof Sohn, Jörg Heil, Andreas Schneeweiss

Prevalence of persistent pain after breast cancer treatment by detection mode among participants in population-based screening programs

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Anabel Romero, Isabel Torà-Rocamora, Marisa Baré, Teresa Barata, Laia Domingo, Joana Ferrer, Núria Torà, Mercè Comas, Carmen Merenciano, Francesc Macià, Xavier Castells, Maria Sala

Development of prognostic signatures for intermediate-risk papillary thyroid cancer

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Kevin Brennan, Christopher Holsinger, Chrysoula Dosiou, John B. Sunwoo, Haruko Akatsu, Robert Haile, Olivier Gevaert

Efficacy and safety of target combined chemotherapy in advanced gastric cancer: a meta-analysis and system review

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Kun Zou, Shuailong Yang, Liang Zheng, Chaogang Yang, Bin Xiong

Simultaneous existence of acute myeloid leukemia and chronic lymphocytic leukemia: a case report

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• Case report

Eman Al Mussaed, Hani Osman, Ghaleb Elyamany

Primary breast cancer cell culture yields intra-tumor heterogeneous subpopulations expressing exclusive patterns of receptor tyrosine kinases

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José Esparza-López, Pier A. Ramos-Elías, Andrea Castro-Sánchez, Leticia Rocha-Zavaleta, Elizabeth Escobar-Arriaga, Alejandro Zentella-Dehesa, Eucario León-Rodríguez, Heriberto Medina-Franco, María de Jesus Ibarra-Sánchez

Bicyclol induces cell cycle arrest and autophagy in HepG2 human hepatocellular carcinoma cells through the PI3K/AKT and Ras/Raf/MEK/ERK pathways

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Yu Wang, Hao Nie, Xin Zhao, Yong Qin, Xingguo Gong

Natural history of superficial head and neck squamous cell carcinoma under scheduled follow-up endoscopic observation with narrow band imaging: retrospective cohort study

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Hiroshi Nakamura, Tomonori Yano, Satoshi Fujii, Tomohiro Kadota, Toshifumi Tomioka, Takeshi Shinozaki, Ryuichi Hayashi, Kazuhiro Kaneko

Programmed death-ligand 1 (PD-L1) characterization of circulating tumor cells (CTCs) in muscle invasive and metastatic bladder cancer patients

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Archana Anantharaman, Terence Friedlander, David Lu, Rachel Krupa, Gayatri Premasekharan, Jeffrey Hough, Matthew Edwards, Rosa Paz, Karla Lindquist, Ryon Graf, Adam Jendrisak, Jessica Louw, Lyndsey Dugan, Sarah Baird, Yipeng Wang, Ryan Dittamore, Pamela L. Paris

A prospective comparison of ER, PR, Ki67 and gene expression in paired sequential core biopsies of primary, untreated breast cancer

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Sirwan M. Hadad, Lee B. Jordan, Pankaj G. Roy, Colin A. Purdie, Takayuki Iwamoto, Lajos Pusztai, Stacy L. Moulder-Thompson, Alastair M. Thompson

Hypoxia promotes chemoresistance in acute lymphoblastic leukemia cell lines by modulating death signaling pathways

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C. Petit, F. Gouel, I. Dubus, C. Heuclin, K. Roget, J. P. Vannier

Internal jugular vein versus subclavian vein as the percutaneous insertion site for totally implantable venous access devices: a meta-analysis of comparative studies

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Shaoyong Wu, Jingxiu Huang, Zongming Jiang, Zhimei Huang, Handong Ouyang, Li Deng, Wenqian Lin, Jin Guo, Weian Zeng

Depletion of γ-glutamylcyclotransferase inhibits breast cancer cell growth via cellular senescence induction mediated by CDK inhibitor upregulation

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Kengo Matsumura, Susumu Nakata, Keiko Taniguchi, Hiromi Ii, Eishi Ashihara, Susumu Kageyama, Akihiro Kawauchi, Tatsuhiro Yoshiki

Salivary DNA methylation panel to diagnose HPV-positive and HPV-negative head and neck cancers

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Yenkai Lim, Yunxia Wan, Dimitrios Vagenas, Dmitry A. Ovchinnikov, Chris F. L. Perry, Melissa J. Davis, Chamindie Punyadeera

Risk factors for pneumothorax in advanced and/or metastatic soft tissue sarcoma patients during pazopanib treatment: a single-institute analysis

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Kenji Nakano, Noriko Motoi, Junichi Tomomatsu, Tabu Gokita, Keisuke Ae, Taisuke Tanizawa, Seiichi Matsumoto, Shunji Takahashi

Polymorphisms in miR-135a-2, miR-219-2 and miR-211 as well as their interaction with cooking oil fume exposure on the risk of lung cancer in Chinese nonsmoking females: a case–control study

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Zhihua Yin, Zhigang Cui, Hang li, Yangwu Ren, Biyun Qian, Nathaniel Rothman, Qing Lan, Baosen Zhou

Epicure: a European epidemiological study of patients with an advanced or metastatic Urothelial Carcinoma (UC) having progressed to a platinum-based chemotherapy

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N. Houédé, G. Locker, C. Lucas, H. Soto Parra, U. Basso, D. Spaeth, R. Tambaro, L. Basterretxea, F. Morelli, C. Theodore, L. Lusuardi, N. Lainez, A. Guillot, G. Tonini, J. Bielle, X. Garcia Del Muro

DNA in serum extracellular vesicles is stable under different storage conditions

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Yang Jin, Keyan Chen, Zongying Wang, Yan Wang, Jianzhi Liu, Li Lin, Yong Shao, Lihua Gao, Huihui Yin, Cong Cui, Zhaoli Tan, Liejun Liu, Chuanhua Zhao, Gairong Zhang, Ru Jia, Lijuan Du, Yuling Chen, Rongrui Liu, Jianming Xu, Xianwen Hu, Youliang Wang

Fluorouracil implants caused a diaphragmatic tumor to be misdiagnosed as liver metastasis: a case report

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• Case report

Yang-Yang Shen, Hong-Wei Qin, Jian-Bo Zhang, Zhen-Dan Wang, Pang Li, Kai Pang, Bo Zhang, Sheng Li, Kai Cui

Ethnic inequalities in cancer incidence and mortality: census-linked cohort studies with 87 million years of person-time follow-up

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Andrea M. Teng, June Atkinson, George Disney, Nick Wilson, Diana Sarfati, Melissa McLeod, Tony Blakely

Influence of dosing times on cisplatin-induced peripheral neuropathy in rats

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Yoshihiro Seto, Fumiyasu Okazaki, Keiji Horikawa, Jing Zhang, Hitoshi Sasaki, Hideto To

Prospective study of postoperative whole breast radiotherapy for Japanese large-breasted women: a clinical and dosimetric comparisons between supine and prone positions and a dose measurement using a breast phantom

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Kana Takahashi, Madoka Morota, Yoshikazu Kagami, Hiroyuki Okamoto, Shuhei Sekii, Koji Inaba, Naoya Murakami, Hiroshi Igaki, Yoshinori Ito, Takashi Uno, Jun Itami

Quantitative assessment of washout in hepatocellular carcinoma using MRI

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Roman Kloeckner, Daniel Pinto dos Santos, Karl-Friedrich Kreitner, Anne Leicher-Düber, Arndt Weinmann, Jens Mittler, Christoph Düber

The circadian clock modulates anti-cancer properties of curcumin

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Ashapurna Sarma, Vishal P. Sharma, Arindam B. Sarkar, M. Chandra Sekar, Karunakar Samuel, Michael E. Geusz

Novel biomarkers that assist in accurate discrimination of squamous cell carcinoma from adenocarcinoma of the lung

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Kazuya Takamochi, Hiroko Ohmiya, Masayoshi Itoh, Kaoru Mogushi, Tsuyoshi Saito, Kieko Hara, Keiko Mitani, Yasushi Kogo, Yasunari Yamanaka, Jun Kawai, Yoshihide Hayashizaki, Shiaki Oh, Kenji Suzuki, Hideya Kawaji

Weight and weight changes throughout life and postmenopausal breast cancer risk: a case-control study in France

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Emilie Cordina-Duverger, Thérèse Truong, Antoinette Anger, Marie Sanchez, Patrick Arveux, Pierre Kerbrat, Pascal Guénel

Role of autophagy and lysosomal drug sequestration in acquired resistance to doxorubicin in MCF-7 cells

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Baoqing Guo, Adam Tam, Stacey A. Santi, Amadeo M. Parissenti

The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways

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Igor Hrgovic, Monika Doll, Johannes Kleemann, Xiao-Fan Wang, Nadja Zoeller, Andreas Pinter, Stefan Kippenberger, Roland Kaufmann, Markus Meissner

Leucine-rich diet alters the 1H-NMR based metabolomic profile without changing the Walker-256 tumour mass in rats

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Laís Rosa Viana, Rafael Canevarolo, Anna Caroline Perina Luiz, Raquel Frias Soares, Camila Lubaczeuski, Ana Carolina de Mattos Zeri, Maria Cristina Cintra Gomes-Marcondes

Comparison of different methods of splenic hilar lymph node dissection for advanced upper- and/or middle-third gastric cancer

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Xin Ji, Tao Fu, Zhao-De Bu, Ji Zhang, Xiao-Jiang Wu, Xiang-Long Zong, Zi-Yu Jia, Biao Fan, Yi-Nan Zhang, Jia-Fu Ji

A survey of physician receptivity to molecular diagnostic testing and readiness to act on results for early-stage colon cancer patients

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Ronald E. Myers, Thomas Wolf, Phillip Shwae, Sarah Hegarty, Stephen C. Peiper, Scott A. Waldman

Effectiveness of community-based football compared to usual care in men with prostate cancer: Protocol for a randomised, controlled, parallel group, multicenter superiority trial (The FC Prostate Community Trial)

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Eik Bjerre, Ditte Marie Bruun, Anders Tolver, Klaus Brasso, Peter Krustrup, Christoffer Johansen, Robin Christensen, Mikael Rørth, Julie Midtgaard

PRognostic factor of Early Death In phase II Trials or the end of ‘sufficient life expectancy’ as an inclusion criterion? (PREDIT model)

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Thomas Grellety, Sophie Cousin, Louis Letinier, Pauline Bosco-Lévy, Stéphanie Hoppe, Damien Joly, Nicolas Penel, Simone Mathoulin-Pelissier, Antoine Italiano

Amino-acid PET versus MRI guided re-irradiation in patients with recurrent glioblastoma multiforme (GLIAA) – protocol of a randomized phase II trial (NOA 10/ARO 2013-1)

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Oliver Oehlke, Michael Mix, Erika Graf, Tanja Schimek-Jasch, Ursula Nestle, Irina Götz, Sabine Schneider-Fuchs, Astrid Weyerbrock, Irina Mader, Brigitta G. Baumert, Susan C. Short, Philipp T. Meyer, Wolfgang A. Weber, Anca-Ligia Grosu

DARS: a phase III randomised multicentre study of dysphagia- optimised intensity- modulated radiotherapy (Do-IMRT) versus standard intensity- modulated radiotherapy (S-IMRT) in head and neck cancer

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Imran Petkar, Keith Rooney, Justin W. G. Roe, Joanne M. Patterson, David Bernstein, Justine M. Tyler, Marie A. Emson, James P. Morden, Kathrin Mertens, Elizabeth Miles, Matthew Beasley, Tom Roques, Shreerang A. Bhide, Kate L. Newbold, Kevin J. Harrington, Emma Hall, Christopher M. Nutting

Data in longitudinal randomised controlled trials in cancer pain: is there any loss of the information available in the data? Results of a systematic literature review and guideline for reporting

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Odile Sauzet, Maren Kleine, John E. Williams

Selective depletion of tumour suppressors Deleted in Colorectal Cancer (DCC) and neogenin by environmental and endogenous serine proteases: linking diet and cancer

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Caroline M. Forrest, Kara McNair, Maria C. J. Vincenten, L. Gail Darlington, Trevor W. Stone

Insulin growth factor 1 like receptor (IGF-1R)

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Gopal Iyer, James Price, Shay Bourgeois, Eric Armstrong, Shyhmin Huang, Paul M. Harari

With or without reirradiation in advanced local recurrent nasopharyngeal carcinoma: a case–control study

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Li-Ting Liu, Qiu-Yan Chen, Lin-Quan Tang, Lu Zhang, Shan-Shan Guo, Ling Guo, Hao-Yuan Mo, Chong Zhao, Xiang Guo, Ming-Yuan Chen, Chao-Nan Qian, Mu-Sheng Zeng, Ming-Huang Hong, Jian-Yong Shao, Ying Sun, Jun Ma, Hai-Qiang Mai

A phase I study of nedaplatin, pemetrexed and thoracic intensity-modulated radiotherapy for inoperable stage III lung adenocarcinoma

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Yiyu Lu, Weiguang Gu, Jin Deng, Hua Yang, Wen Yang

Polymorphisms in the estrogen receptor alpha gene (ESR1), daily cycling estrogen and mammographic density phenotypes.

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F. N. Fjeldheim, H. Frydenberg, V. G. Flote, A. McTiernan, A-S Furberg, P. T. Ellison, E. S. Barrett, T. Wilsgaard, G. Jasienska, G. Ursin, E. A. Wist, I. Thune

Establishment of an innovative staging system for extramedullary plasmacytoma

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Qian Zhu, Xiong Zou, Rui You, Rou Jiang, Meng-Xia Zhang, You-Ping Liu, Chao-Nan Qian, Hai-Qiang Mai, Ming-Huang Hong, Ling Guo, Ming-Yuan Chen

Post-inhaled corticosteroid pulmonary tuberculosis and pneumonia increases lung cancer in patients with COPD

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Ming-Fang Wu, Zhi-Hong Jian, Jing-Yang Huang, Cheng-Feng Jan, Oswald Ndi Nfor, Kai-Ming Jhang, Wen-Yuan Ku, Chien-Chang Ho, Chia-Chi Lung, Hui-Hsien Pan, Min-Chen Wu, Yung-Po Liaw

Phase II study of TP300 in patients with advanced gastric or gastro-oesophageal junction adenocarcinoma

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David Propper, Keith Jones, D. Alan Anthoney, Wasat Mansoor, Daniel Ford, Martin Eatock, Roshan Agarwal, Michiyasu Inatani, Tomohisa Saito, Masaichi Abe, T. R. Jeffry Evans

SAKK 24/09: safety and tolerability of bevacizumab plus paclitaxel vs. bevacizumab plus metronomic cyclophosphamide and capecitabine as first-line therapy in patients with HER2-negative advanced stage breast cancer - a multicenter, randomized phase III trial

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Christoph Rochlitz, Martin Bigler, Roger von Moos, Jürg Bernhard, Klazien Matter-Walstra, Andreas Wicki, Khalil Zaman, Sandro Anchisi, Marc Küng, Kyung-Jae Na, Daniela Bärtschi, Markus Borner, Tamara Rordorf, Daniel Rauch, Andreas Müller, Thomas Ruhstaller, Marcus Vetter, Andreas Trojan, Ursula Hasler-Strub, Richard Cathomas, Ralph Winterhalder

Aldehyde dehydrogenase activity plays a Key role in the aggressive phenotype of neuroblastoma

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Marjorie Flahaut, Nicolas Jauquier, Nadja Chevalier, Katya Nardou, Katia Balmas Bourloud, Jean-Marc Joseph, David Barras, Christian Widmann, Nicole Gross, Raffaele Renella, Annick Mühlethaler-Mottet

ΔNp63α expression induces loss of cell adhesion in triple-negative breast cancer cells

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Marta Nekulova, Jitka Holcakova, Xiaolian Gu, Vaclav Hrabal, Sotiris Galtsidis, Paulina Orzol, Yajing Liu, Stella Logotheti, Vassilis Zoumpourlis, Karin Nylander, Philip J Coates, Borivoj Vojtesek

Prognostic value of computed tomography characteristics for overall survival in patients with maxillary cancer

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Ying Yuan, Jingbo Wang, Yingwei Wu, Guojun Li, Xiaofeng Tao

MiR-9 is overexpressed in spontaneous canine osteosarcoma and promotes a metastatic phenotype including invasion and migration in osteoblasts and osteosarcoma cell lines

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Joelle M. Fenger, Ryan D. Roberts, O. Hans Iwenofu, Misty D. Bear, Xiaoli Zhang, Jason I. Couto, Jaime F. Modiano, William C. Kisseberth, Cheryl A. London

Risk factors for cancer development in type 2 diabetes: A retrospective case-control study

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Mariusz Dąbrowski, Elektra Szymańska-Garbacz, Zofia Miszczyszyn, Tadeusz Dereziński, Leszek Czupryniak

Complete pathological response following neoadjuvant FOLFIRINOX in borderline resectable pancreatic cancer - a case report and review

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• Case report

Mišo Gostimir, Sean Bennett, Terence Moyana, Harman Sekhon, Guillaume Martel

Quality of life after cancer—How the extent of impairment is influenced by patient characteristics

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Elisabeth Peters, Laura Mendoza Schulz, Monika Reuss-Borst

Claudin-4 activity in ovarian tumor cell apoptosis resistance and migration

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Douglas A. Hicks, Carly E. Galimanis, Patricia G. Webb, Monique A. Spillman, Kian Behbakht, Margaret C. Neville, Heidi K. Baumgartner

Gene and miRNA expression signature of Lewis lung carcinoma LLC1 cells in extracellular matrix enriched microenvironment

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Vaidotas Stankevicius, Gintautas Vasauskas, Danute Bulotiene, Stase Butkyte, Sonata Jarmalaite, Ricardas Rotomskis, Kestutis Suziedelis

Capsaicin mediates caspases activation and induces apoptosis through P38 and JNK MAPK pathways in human renal carcinoma

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Tao Liu, Gang Wang, Huangheng Tao, Zhonghua Yang, Yongzhi Wang, Zhe Meng, Rui Cao, Yu Xiao, Xinghuan Wang, Jiajie Zhou

Combined application of anti-VEGF and anti-EGFR attenuates the growth and angiogenesis of colorectal cancer mainly through suppressing AKT and ERK signaling in mice model

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Chenbo Ding, Longmei Li, Taoyu Yang, Xiaobo Fan, Guoqiu Wu

Intrahepatic cholangiocarcinoma prognostic determination using pre-operative serum C-reactive protein levels

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Zi-Ying Lin, Zhen-Xing Liang, Pei-Lin Zhuang, Jie-Wei Chen, Yun Cao, Li-Xu Yan, Jing-Ping Yun, Dan Xie, Mu-Yan Cai

Successful treatment of gemcitabine-induced acute interstitial pneumonia with imatinib mesylate: a case report

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• Case report

Elisabetta Fenocchio, Ilaria Depetris, Delia Campanella, Lucia Garetto, Fabrizio Carnevale Schianca, Danilo Galizia, Giovanni Grignani, Massimo Aglietta, Francesco Leone

Tumor apelin, not serum apelin, is associated with the clinical features and prognosis of gastric cancer

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Meiyan Feng, Guodong Yao, Hongwei Yu, Yu Qing, Kuan Wang

Molecular profile of 5-fluorouracil pathway genes in colorectal carcinoma

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T. Kunicka, P. Prochazka, I. Krus, P. Bendova, M. Protivova, S. Susova, V. Hlavac, V. Liska, P. Novak, M. Schneiderova, P. Pitule, J. Bruha, O. Vycital, P. Vodicka, P. Soucek

Time trend analysis of primary liver cancer incidence in Sihui county of Guangdong Province, China (1987–2011)

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Wenyi Liu, Qing Liu, Qihong Huang, Yuqiang Lu, Shanghang Xie, Aihua Lin, Sumei Cao

Inactivation of the tumor suppressor gene von Hippel-Lindau (VHL) in granulocytes contributes to development of liver hemangiomas in a mouse model

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Hannah L. Bader, Tien Hsu

CT guided cryoablation for locally recurrent or metastatic bone and soft tissue tumor: initial experience

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Michiro Susa, Kazutaka Kikuta, Robert Nakayama, Kazumasa Nishimoto, Keisuke Horiuchi, Sota Oguro, Masanori Inoue, Hideki Yashiro, Seishi Nakatsuka, Masaya Nakamura, Morio Matsumoto, Kazuhiro Chiba, Hideo Morioka

Incidence and Survival of urothelial carcinoma of the urinary bladder in Norway 1981-2014

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B. K. Andreassen, B. Aagnes, R. Gislefoss, M. Andreassen, R. Wahlqvist

Interplay of N-Cadherin and matrix metalloproteinase 9 enhances human nasopharyngeal carcinoma cell invasion

• Open Access
• Research article

Chih-Chin Hsu, Shiang-Fu Huang, Jong-Shyan Wang, Wing-Keung Chu, Ju-En Nien, Wei-Shan Chen, Shu-Er Chow

Disseminated carcinomatosis of the bone marrow from pancreatic cancer: a case report

• Open Access
• Case report

Hiroki Namikawa, Yasuhiko Takemoto, Ayako Makuuchi, Masanori Kobayashi, Shigeki Kinuhata, Mina Morimura, Takashi Ikebe, Hiromu Tanaka, Taichi Shuto

The REFRACT-LYMA cohort study: a French observational prospective cohort study of patients with mantle cell lymphoma

• Open Access
• Study protocol

Matthieu Hanf, David Chiron, Sophie de Visme, Cyrille Touzeau, Hervé Maisonneuve, Henry Jardel, Catherine Pellat-Deceunynck, Martine Amiot, Steven le Gouill

Erratum to: PNA clamping-assisted fluorescence melting curve analysis for detecting EGFR and KRAS mutations in the circulating tumor DNA of patients with advanced non-small cell lung cancer

• Open Access
• Erratum

Ji-Youn Han, Jae-Jin Choi, Jin Young Kim, You Lim Han, Geon Kook Lee

Projecting productivity losses for cancer-related mortality 2011 – 2030

• Open Access
• Research article

Alison Pearce, Cathy Bradley, Paul Hanly, Ciaran O’Neill, Audrey Alforque Thomas, Michal Molcho, Linda Sharp

A diagnostic marker for superficial urothelial bladder carcinoma: lack of nuclear ATBF1 (ZFHX3) by immunohistochemistry suggests malignant progression

• Open Access
• Research article

Makoto Kawaguchi, Noboru Hara, Vladimir Bilim, Hiroshi Koike, Mituko Suzuki, Tae-Sun Kim, Nan Gao, Yu Dong, Sheng Zhang, Yuji Fujinawa, Osamu Yamamoto, Hiromi Ito, Yoshihiko Tomita, Yuchi Naruse, Akira Sakamaki, Yoko Ishii, Koichi Tsuneyama, Masaaki Inoue, Johbu Itoh, Masanori Yasuda, Nobuo Sakata, Cha-Gyun Jung, Satoshi Kanazawa, Hiroyasu Akatsu, Hiroshi Minato, Takayuki Nojima, Kiyofumi Asai, Yutaka Miura

miR-10b exerts oncogenic activity in human hepatocellular carcinoma cells by targeting expression of CUB and sushi multiple domains 1 (CSMD1)

• Open Access
• Research article

Qiao Zhu, Li Gong, Jun Wang, Qian Tu, Li Yao, Jia-Rui Zhang, Xiu-Juan Han, Shao-Jun Zhu, Shu-Mei Wang, Yan-Hong Li, Wei Zhang

A novel variant on chromosome 6p21.1 is associated with the risk of developing colorectal cancer: a two-stage case-control study in Han Chinese

• Open Access
• Research article

Chunxiao Xu, Dan Zhou, Feixia Pan, Yi Liu, Dandan zhang, Aifen Lin, Xiaoping Miao, Yaqin Ni, Duo Lv, Shuai Zhang, Xiaobo Li, Yimin Zhu, Maode Lai

Sentinel lymph node biopsy after neoadjuvant chemotherapy for breast cancer: retrospective comparative evaluation of clinically axillary lymph node positive and negative patients, including those with axillary lymph node metastases confirmed by fine needle aspiration

• Open Access
• Research article

Yue Yu, Ning Cui, Heng-Yu Li, Yan-Mei Wu, Lu Xu, Min Fang, Yuan Sheng

Phase-specific and lifetime costs of cancer care in Ontario, Canada

• Open Access
• Research article

Claire de Oliveira, Reka Pataky, Karen E. Bremner, Jagadish Rangrej, Kelvin K. W. Chan, Winson Y. Cheung, Jeffrey S. Hoch, Stuart Peacock, Murray D. Krahn

Hepatocellular carcinoma-targeted drug discovery through image-based phenotypic screening in co-cultures of HCC cells with hepatocytes

• Open Access
• Research article

Jae-Woo Jang, Yeonhwa Song, Kang Mo Kim, Jin-Sun Kim, Eun Kyung Choi, Joon Kim, Haengran Seo

Identification of BRCA1-like triple-negative breast cancers by quantitative multiplex-ligation-dependent probe amplification (MLPA) analysis of BRCA1-associated chromosomal regions: a validation study

• Open Access
• Research article

Eva Gross, Harm van Tinteren, Zhou Li, Sandra Raab, Christina Meul, Stefanie Avril, Nadja Laddach, Michaela Aubele, Corinna Propping, Apostolos Gkazepis, Manfred Schmitt, Alfons Meindl, Petra M. Nederlof, Marion Kiechle, Esther H. Lips

Development of OXY111A, a novel hypoxia-modifier as a potential antitumor agent in patients with hepato-pancreato-biliary neoplasms - Protocol of a first Ib/IIa clinical trial

• Open Access
• Study protocol

Perparim Limani, Michael Linecker, Philipp Kron, Panagiotis Samaras, Bernhard Pestalozzi, Roger Stupp, Alexander Jetter, Philipp Dutkowski, Beat Müllhaupt, Andrea Schlegel, Claude Nicolau, Jean-Marie Lehn, Henrik Petrowsky, Bostjan Humar, Rolf Graf, Pierre-Alain Clavien

Inhibition of eEF-2 kinase sensitizes human nasopharyngeal carcinoma cells to lapatinib-induced apoptosis through the Src and Erk pathways

• Open Access
• Research article

Lin Liu, PeiYu Huang, ZhiHui Wang, Nan Chen, Con Tang, Zhong Lin, PeiJian Peng

Ridaforolimus (MK-8669) synergizes with Dalotuzumab (MK-0646) in hormone-sensitive breast cancer

• Open Access
• Research article

Marc A. Becker, Xiaonan Hou, Piyawan Tienchaianada, Brian B. Haines, Sean C. Harrington, S. John Weroha, Sriram Sathyanarayanan, Paul Haluska

KLHL21, a novel gene that contributes to the progression of hepatocellular carcinoma

• Open Access
• Research article

Lei Shi, Wenfa Zhang, Fagui Zou, Lihua Mei, Gang Wu, Yong Teng

INNOVATE: A prospective cohort study combining serum and urinary biomarkers with novel diffusion-weighted magnetic resonance imaging for the prediction and characterization of prostate cancer

• Open Access
• Study protocol

Edward Johnston, Hayley Pye, Elisenda Bonet-Carne, Eleftheria Panagiotaki, Dominic Patel, Myria Galazi, Susan Heavey, Lina Carmona, Alexander Freeman, Giorgia Trevisan, Clare Allen, Alexander Kirkham, Keith Burling, Nicola Stevens, David Hawkes, Mark Emberton, Caroline Moore, Hashim U Ahmed, David Atkinson, Manuel Rodriguez-Justo, Tony Ng, Daniel Alexander, Hayley Whitaker, Shonit Punwani

Efficacy and safety profile of nab-paclitaxel plus gemcitabine in patients with metastatic pancreatic cancer treated to disease progression: a subanalysis from a phase 3 trial (MPACT)

• Open Access
• Research article

Arndt Vogel, Josefine Römmler-Zehrer, Jack Shiansong Li, Desmond McGovern, Alfredo Romano, Michael Stahl

Selumetinib suppresses cell proliferation, migration and trigger apoptosis, G1 arrest in triple-negative breast cancer cells

• Open Access
• Research article

Yan Zhou, Shuchen Lin, Kuo-Fu Tseng, Kun Han, Yaling Wang, Zhi-hua Gan, Da-liu Min, Hai-yan Hu

Cervical and breast cancer screening uptake among women with serious mental illness: a data linkage study

• Open Access
• Research article

Charlotte Woodhead, Ruth Cunningham, Mark Ashworth, Elizabeth Barley, Robert J. Stewart, Max J. Henderson

Validation of the CancerMath prognostic tool for breast cancer in Southeast Asia

• Open Access
• Research article

Hui Miao, Mikael Hartman, Helena M. Verkooijen, Nur Aishah Taib, Hoong-Seam Wong, Shridevi Subramaniam, Cheng-Har Yip, Ern-Yu Tan, Patrick Chan, Soo-Chin Lee, Nirmala Bhoo-Pathy

Reduced mRNA expression levels of NFE2L2 are associated with poor outcome in breast cancer patients

• Open Access
• Research article

Barbara Wolf, Georg Goebel, Hubert Hackl, Heidi Fiegl

In vitro and in vivo activity of miR-92a–Locked Nucleic Acid (LNA)–Inhibitor against endometrial cancer

• Open Access
• Research article

Anna Torres, Joanna Kozak, Agnieszka Korolczuk, Paulina Wdowiak, Ewa Domańska-Glonek, Ryszard Maciejewski, Kamil Torres

Additive value of pre-operative and one-month post-operative lymphocyte count for death-risk stratification in patients with resectable pancreatic cancer: a multicentric study

• Open Access
• Research article

Christelle d’Engremont, Dewi Vernerey, Anne-Laure Pointet, Gaël Simone, Francine Fein, Bruno Heyd, Stéphane Koch, Lucine Vuitton, Stefano Kim, Marine Jary, Najib Lamfichek, Celia Turco, Zaher Lakkis, Anne Berger, Franck Bonnetain, Julien Taieb, Philippe Bachellier, Christophe Borg

Induction of autophagy by ARHI (DIRAS3) alters fundamental metabolic pathways in ovarian cancer models

• Open Access
• Research article

Argentina Ornelas, Christopher R. McCullough, Zhen Lu, Niki M. Zacharias, Lindsay E. Kelderhouse, Joshua Gray, Hailing Yang, Brian J. Engel, Yan Wang, Weiqun Mao, Margie N. Sutton, Pratip K. Bhattacharya, Robert C. Bast Jr., Steven W. Millward

RAS testing practices and RAS mutation prevalence among patients with metastatic colorectal cancer: results from a Europe-wide survey of pathology centres

• Open Access
• Research article

Annemarie Boleij, Véronique Tack, Aliki Taylor, George Kafatos, Sophie Jenkins-Anderson, Lien Tembuyser, Els Dequeker, J. Han van Krieken

miR-124-3p functions as a tumor suppressor in breast cancer by targeting CBL

• Open Access
• Research article

Yanbo Wang, Luxiao Chen, Zhenyu Wu, Minghai Wang, Fangfang Jin, Nan Wang, Xiuting Hu, Zhengya Liu, Chen-Yu Zhang, Ke Zen, Jiangning Chen, Hongwei Liang, Yujing Zhang, Xi Chen

Invasive myoepithelial carcinoma ex pleomorphic adenoma of the major salivary gland: two case reports

• Open Access
• Case report

Takahiro Wakasaki, Marie Kubota, Yutaka Nakashima, Eri Tomonobe, Takenao Mihara, Junichi Fukushima

Epidemiological study of HER-2 mutations among EGFR wild-type lung adenocarcinoma patients in China

• Open Access
• Research article

Xuefei Li, Chao Zhao, Chunxia Su, Shengxiang Ren, Xiaoxia Chen, Caicun Zhou

Subcellular localisation of pMEK has a different prognosis in locally advanced head and neck cancer treated with concomitant radiochemotherapy

• Open Access
• Research article

J. Gomez-Millan, B. Pajares, L. Perez-Villa, A. Carnero, M. Alvarez, V. De Luque, F. Rivas, J. M. Trigo, M. D. Toledo, E. Alba, J. A. Medina

Living well after breast cancer randomized controlled trial protocol: evaluating a telephone-delivered weight loss intervention versus usual care in women following treatment for breast cancer

• Open Access
• Study protocol

Marina M. Reeves, Caroline O. Terranova, Jane M. Erickson, Jennifer R. Job, Denise S. K. Brookes, Nicole McCarthy, Ingrid J. Hickman, Sheleigh P. Lawler, Brianna S. Fjeldsoe, Genevieve N. Healy, Elisabeth A. H. Winkler, Monika Janda, J. Lennert Veerman, Robert S. Ware, Johannes B. Prins, Theo Vos, Wendy Demark-Wahnefried, Elizabeth G. Eakin

Enhanced therapeutic efficacy of LHRHa-targeted brucea javanica oil liposomes for ovarian cancer

• Open Access
• Research article

Hongxia Ye, Xiaojuan Liu, Jiangchuan Sun, Shenyin Zhu, Yi Zhu, Shufang Chang

Colorectal Carcinogenesis in the A/J Min/+ Mouse Model is Inhibited by Hemin, Independently of Dietary Fat Content and Fecal Lipid Peroxidation Rate

• Open Access
• Research article

Christina Steppeler, Marianne Sødring, Jan Erik Paulsen

Prognostic contribution of mammographic breast density and HER2 overexpression to the Nottingham Prognostic Index in patients with invasive breast cancer

• Open Access
• Research article

Amro Masarwah, Päivi Auvinen, Mazen Sudah, Vaiva Dabravolskaite, Otso Arponen, Anna Sutela, Sanna Oikari, Veli-Matti Kosma, Ritva Vanninen

Long-term survival analysis in combined transarterial embolization and stereotactic body radiation therapy versus stereotactic body radiation monotherapy for unresectable hepatocellular carcinoma >5 cm

• Open Access
• Research article

Ting-Shi Su, Huan-Zhen Lu, Tao Cheng, Ying Zhou, Yong Huang, Ying-Chuan Gao, Min-Yang Tang, Hua-Yan Jiang, Zu-Ping Lian, En-Cun Hou, Ping Liang

Study protocol of the CHOiCE trial: a three-armed, randomized, controlled trial of home-based HPV self-sampling for non-participants in an organized cervical cancer screening program

• Open Access
• Study protocol

Mette Tranberg, Bodil Hammer Bech, Jan Blaakær, Jørgen Skov Jensen, Hans Svanholm, Berit Andersen

Increased serum amyloid A as potential diagnostic marker for lung cancer: a meta-analysis based on nine studies

• Open Access
• Research article

Rong Biaoxue, Liu Hua, Gao Wenlong, Yang Shuanying

A prospective multicenter study on bladder cancer: the COBLAnCE cohort

• Open Access
• Study protocol

Simone Benhamou, Julia Bonastre, Karine Groussard, François Radvanyi, Yves Allory, Thierry Lebret

Web-based stress management for newly diagnosed cancer patients (STREAM-1): a randomized, wait-list controlled intervention study

• Open Access
• Study protocol

Astrid Grossert, Corinne Urech, Judith Alder, Jens Gaab, Thomas Berger, Viviane Hess

Risk of uterine, ovarian and breast cancer following pelvic inflammatory disease: a nationwide population-based retrospective cohort study

• Open Access
• Research article

Cheng-Che Shen, Li-Yu Hu, Albert C. Yang, Yung-Yen Chiang, Jeng-Hsiu Hung, Shih-Jen Tsai

The differential role of HTRA1 in HPV-positive and HPV-negative cervical cell line proliferation

• Open Access
• Research article

Bruna Stuqui, André Luis Giacometti Conceição, Lara Termini, Laura Sichero, Luisa Lina Villa, Paula Rahal, Marília de Freitas Calmon

The expression pattern of matrix-producing tumor stroma is of prognostic importance in breast cancer

• Open Access
• Research article

Sofia Winslow, Kajsa Ericson Lindquist, Anders Edsjö, Christer Larsson

Planning TTFields treatment using the NovoTAL system-clinical case series beyond the use of MRI contrast enhancement

• Open Access
• Case report

Jennifer Connelly, Adília Hormigo, Nimish Mohilie, Jethro Hu, Aafia Chaudhry, Nicholas Blondin

A consultation training program for physicians for communication about complementary medicine with breast cancer patients: a prospective, multi-center, cluster-randomized, mixed-method pilot study

• Open Access
• Research article

Susanne Blödt, Nadine Mittring, Lena Schützler, Felix Fischer, Christine Holmberg, Markus Horneber, Adele Stapf, Claudia M. Witt

Pancreatic resection for intraductal papillary mucinous neoplasm– a thirteen-year single center experience

• Open Access
• Research article

Katharina Marsoner, Johannes Haybaeck, Dora Csengeri, James Elvis Waha, Jakob Schagerl, Rainer Langeder, Hans Joerg Mischinger, Peter Kornprat

Is alcohol consumption a risk factor for prostate cancer? A systematic review and meta–analysis

• Open Access
• Research article

Jinhui Zhao, Tim Stockwell, Audra Roemer, Tanya Chikritzhs

LPA receptor 1 mediates LPA-induced ovarian cancer metastasis: an in vitro and in vivo study

• Open Access
• Research article

Xuechen Yu, Yuanzhen Zhang, Huijun Chen

Requirement of ABC transporter inhibition and Hoechst 33342 dye deprivation for the assessment of side population-defined C6 glioma stem cell metabolism using fluorescent probes

• Open Access
• Research article

Yoshitaka Murota, Kouichi Tabu, Tetsuya Taga

Estimating long-term clinical effectiveness and cost-effectiveness of HPV 16/18 vaccine in China

• Open Access
• Research article

Qian Zhang, Yi-Jun Liu, Shang-Ying Hu, Fang-Hui Zhao

Temporal trends in the risk of developing multiple primary cancers: a systematic review

• Open Access
• Research article

Yuanzi Ye, Amanda L. Neil, Karen E. Wills, Alison J. Venn

Response biomarkers: re-envisioning the approach to tailoring drug therapy for cancer

• Open Access
• Review

Shahil Amin, Oliver F. Bathe

Molecular features of the cytotoxicity of an NHE inhibitor: Evidence of mitochondrial alterations, ROS overproduction and DNA damage

• Open Access
• Research article

Francesca Aredia, Sebastian Czaplinski, Simone Fulda, A. Ivana Scovassi

Assessment of human papillomavirus E6/E7 oncogene expression as cervical disease biomarker

• Open Access
• Research article

Nerea Fontecha, Miren Basaras, Silvia Hernáez, Daniel Andía, Ramón Cisterna

Identification of microRNA profile specific to cancer stem-like cells directly isolated from human larynx cancer specimens

• Open Access
• Research article

Omer Faruk Karatas, Ilknur Suer, Betul Yuceturk, Mehmet Yilmaz, Buge Oz, Gulgun Guven, Harun Cansiz, Chad J. Creighton, Michael Ittmann, Mustafa Ozen

Aberrant activation of Notch signaling in extrahepatic cholangiocarcinoma: clinicopathological features and therapeutic potential for cancer stem cell-like properties

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• Research article

Shuichi Aoki, Masamichi Mizuma, Yayoi Takahashi, Yoichi Haji, Ryo Okada, Tomoya Abe, Hideaki Karasawa, Keiichi Tamai, Takaho Okada, Takanori Morikawa, Hiroki Hayashi, Kei Nakagawa, Fuyuhiko Motoi, Takeshi Naitoh, Yu Katayose, Michiaki Unno

Frequency of Her2/neu expression in colorectal adenocarcinoma: a study from developing South Asian Country

• Open Access
• Research article

Asma Shabbir, Talat Mirza, Abdullah Bin Khalid, Muhammad Asif Qureshi, Sadaf Ahmed Asim

Single administration of Selective Internal Radiation Therapy versus continuous treatment with sorafeNIB in locally advanced hepatocellular carcinoma (SIRveNIB): study protocol for a phase iii randomized controlled trial

• Open Access
• Study protocol

Mihir Gandhi, Su Pin Choo, Choon Hua Thng, Say Beng Tan, Albert Su Chong Low, Peng Chung Cheow, Anthony Soon Whatt Goh, Kiang Hiong Tay, Richard Hoau Gong Lo, Brian Kim Poh Goh, Jen San Wong, David Chee Eng Ng, Khee Chee Soo, Wei Ming Liew, Pierce K. H. Chow

Vorinostat enhances the cisplatin-mediated anticancer effects in small cell lung cancer cells

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Chun-Hao Pan, Ying-Fang Chang, Ming-Shuo Lee, B-Chen Wen, Jen-Chung Ko, Sheng-Kai Liang, Mei-Chih Liang

Management of controversial gastroenteropancreatic neuroendocrine tumour clinical situations with somatostatin analogues: results of a Delphi questionnaire panel from the NETPraxis program

• Open Access
• Research article

Isabel Sevilla, Ángel Segura, Jaume Capdevila, Carlos López, Rocío García-Carbonero, Enrique Grande

Comparison of the pharmacokinetics between L-BPA and L-FBPA using the same administration dose and protocol: a validation study for the theranostic approach using [18F]-L-FBPA positron emission tomography in boron neutron capture therapy

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• Research article

Tsubasa Watanabe, Yoshihide Hattori, Youichiro Ohta, Miki Ishimura, Yosuke Nakagawa, Yu Sanada, Hiroki Tanaka, Satoshi Fukutani, Shin-ichiro Masunaga, Masahiro Hiraoka, Koji Ono, Minoru Suzuki, Mitsunori Kirihata

Antineoplastic treatment effect on bone mineral density in Mexican breast cancer patients

• Open Access
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Karina Monroy-Cisneros, Julián Esparza-Romero, Mauro E. Valencia, Alfonso G. Guevara-Torres, Rosa O. Méndez-Estrada, Iván Anduro-Corona, Humberto Astiazarán-García

Chronic hepatitis infection is associated with extrahepatic cancer development: a nationwide population-based study in Taiwan

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• Research article

Abram Bunya Kamiza, Fu-Hsiung Su, Wen-Chang Wang, Fung-Chang Sung, Shih-Ni Chang, Chih-Ching Yeh

A case series of intestinal adenomatous polyposis of unidentified etiology; a late effect of irradiation?

• Open Access
• Case report

Lisanne Sara Rigter, Frank G. J. Kallenberg, Barbara Bastiaansen, Theo A. M. van Os, Floor E. van Leeuwen, Monique Esther van Leerdam, Evelien Dekker

Let-7 inhibits self-renewal of hepatocellular cancer stem-like cells through regulating the epithelial-mesenchymal transition and the Wnt signaling pathway

• Open Access
• Research article

Bin Jin, Wei Wang, Xiang-xin Meng, Gang Du, Jia Li, Shi-zhe Zhang, Bing-hai Zhou, Zhi-hao Fu

Frequency of EGFR T790M mutation and multimutational profiles of rebiopsy samples from non-small cell lung cancer developing acquired resistance to EGFR tyrosine kinase inhibitors in Japanese patients

• Open Access
• Research article

Ryo Ko, Hirotsugu Kenmotsu, Masakuni Serizawa, Yasuhiro Koh, Kazushige Wakuda, Akira Ono, Tetsuhiko Taira, Tateaki Naito, Haruyasu Murakami, Mitsuhiro Isaka, Masahiro Endo, Takashi Nakajima, Yasuhisa Ohde, Nobuyuki Yamamoto, Kazuhisa Takahashi, Toshiaki Takahashi

Early evaluation of irradiated parotid glands with intravoxel incoherent motion MR imaging: correlation with dynamic contrast-enhanced MR imaging

• Open Access
• Research article

Nan Zhou, Chen Chu, Xin Dou, Ming Li, Song Liu, Lijing Zhu, Baorui Liu, Tingting Guo, Weibo Chen, Jian He, Jing Yan, Zhengyang Zhou, Xiaofeng Yang, Tian Liu

Prevalence and distribution of cervical high-risk human papillomavirus and cytological abnormalities in women living with HIV in Denmark – the SHADE

• Open Access
• Research article

Kristina Thorsteinsson, Merete Storgaard, Terese L. Katzenstein, Steen Ladelund, Frederikke Falkencrone Rønsholt, Isik Somuncu Johansen, Gitte Pedersen, Lailoma Hashemi, Lars Nørregård Nielsen, Lisbeth Nilas, Niels Obel, Jesper Bonde, Anne-Mette Lebech

Treatment of a chemoresistant neuroblastoma cell line with the antimalarial ozonide OZ513

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Don W. Coulter, Timothy R. McGuire, John G. Sharp, Erin M. McIntyre, Yuxiang Dong, Xiaofang Wang, Shawn Gray, Gracey R. Alexander, Nagendra K. Chatuverdi, Shantaram S. Joshi, Xiaoyu Chen, Jonathan L. Vennerstrom

Impact of clinical parameters and systemic inflammatory status on epidermal growth factor receptor-mutant non-small cell lung cancer patients readministration with epidermal growth factor receptor tyrosine kinase inhibitors

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• Research article

Yu-Mu Chen, Chien-Hao Lai, Kun-Ming Rau, Cheng-Hua Huang, Huang-Chih Chang, Tung-Ying Chao, Chia-Cheng Tseng, Wen-Feng Fang, Yu-Hsiu Chung, Yi-Hsi Wang, Mao-Chang Su, Kuo-Tung Huang, Shih-Feng Liu, Hung-Chen Chen, Ya-Chun Chang, Yu-Ping Chang, Chin-Chou Wang, Meng-Chih Lin

Secreted Frizzled-Related Protein 2 (sFRP2) promotes osteosarcoma invasion and metastatic potential

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Piti Techavichit, Yang Gao, Lyazat Kurenbekova, Ryan Shuck, Lawrence A. Donehower, Jason T. Yustein

Binding of galectin-1 to breast cancer cells MCF7 induces apoptosis and inhibition of proliferation in vitro in a 2D- and 3D- cell culture model

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Pamina Geiger, Barbara Mayer, Irmi Wiest, Sandra Schulze, Udo Jeschke, Tobias Weissenbacher

Growth hormone is increased in the lungs and enhances experimental lung metastasis of melanoma in DJ-1 KO mice

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Chia-Hung Chien, Ming-Jen Lee, Houng-Chi Liou, Horng-Huei Liou, Wen-Mei Fu

Improved nutrition in adolescents and young adults after childhood cancer - INAYA study

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• Research article

J. Quidde, J. von Grundherr, B. Koch, C. Bokemeyer, G. Escherich, L. Valentini, D. Buchholz, G. Schilling, A. Stein

Esophageal squamous cell carcinoma invasion is inhibited by Activin A in ACVRIB-positive cells

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Holli A. Loomans, Shanna A. Arnold, Laura L. Quast, Claudia D. Andl

Investigation of optical coherence micro-elastography as a method to visualize micro-architecture in human axillary lymph nodes

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• Research article

Kelsey M. Kennedy, Lixin Chin, Philip Wijesinghe, Robert A. McLaughlin, Bruce Latham, David D. Sampson, Christobel M. Saunders, Brendan F. Kennedy

Complete response of extramedullary relapse in breast of acute T lymphoblastic leukemia after bone marrow transplantation to chemoradiotherapy: a case report and literature review

• Open Access
• Case report

Bailong Liu, Bin Liu, Xu Wang, Liang Guo, Xiaoliang Liu, Wei Han, Lihua Dong, Min Liu

Metastasis-associated in colon cancer-1 and aldehyde dehydrogenase 1 are metastatic and prognostic biomarker for non-small cell lung cancer

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• Research article

Lei Zhou, Lan Yu, Bo Zhu, Shiwu Wu, Wenqing Song, Xiaomeng Gong, Danna Wang

Clinicopathological and prognostic significance of mTOR and phosphorylated mTOR expression in patients with esophageal squamous cell carcinoma: a systematic review and meta-analysis

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• Research article

Shuangjiang Li, Zhiqiang Wang, Jian Huang, Shan Cheng, Heng Du, Guowei Che, Yong Peng

Longitudinal alterations in health-related quality of life and its impact on the clinical course of patients with advanced hepatocellular carcinoma receiving sorafenib treatment

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• Research article

Masako Shomura, Tatehiro Kagawa, Haruka Okabe, Koichi Shiraishi, Shunji Hirose, Yoshitaka Arase, Kota Tsuruya, Sachiko Takahira, Tetsuya Mine

Activins and their related proteins in colon carcinogenesis: insights from early and advanced azoxymethane rat models of colon cancer

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Bassem Refaat, Adel Galal El-Shemi, Amr Mohamed Mohamed, Osama Adnan Kensara, Jawwad Ahmad, Shakir Idris

High-mobility group protein box1 expression correlates with peritumoral macrophage infiltration and unfavorable prognosis in patients with hepatocellular carcinoma and cirrhosis

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• Research article

Qiang-Bo Zhang, Qing-an Jia, Hong Wang, Chun-Xiao Hu, Dong Sun, Run-De Jiang, Zong-Li Zhang

Screening and characterization of novel specific peptides targeting MDA-MB-231 claudin-low breast carcinoma by computer-aided phage display methodologies

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• Research article

Franklin L. Nobrega, Débora Ferreira, Ivone M. Martins, Maria Suarez-Diez, Joana Azeredo, Leon D. Kluskens, Lígia R. Rodrigues

Leptin and insulin up-regulate miR-4443 to suppress NCOA1 and TRAF4, and decrease the invasiveness of human colon cancer cells

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• Research article

Ari Meerson, Hila Yehuda

Synthesis and bio-molecular study of (+)-N-Acetyl-α-amino acid dehydroabietylamine derivative for the selective therapy of hepatocellular carcinoma

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• Research article

Muhammad Ayaz Mustufa, Cigdem Ozen, Imran Ali Hashmi, Afshan Aslam, Jameel Ahmed Baig, Gokhan Yildiz, Shoaib Muhammad, Imam Bakhsh Solangi, Naim ul Hasan Naqvi, Mehmet Ozturk, Firdous Imran Ali

EpCAM as multi-tumour target for near-infrared fluorescence guided surgery

• Open Access
• Research article

P. B. A. A. van Driel, M. C. Boonstra, H. A. J. M. Prevoo, M. van de Giessen, T. J. A. Snoeks, Q. R. J. G. Tummers, S. Keereweer, R. A. Cordfunke, A. Fish, J. D. H. van Eendenburg, B. P. F. Lelieveldt, J. Dijkstra, C. J. H. van de Velde, P. J. K. Kuppen, A. L. Vahrmeijer, C. W. G. M. Löwik, C. F. M. Sier

The validity of pediatric cancer diagnoses in a population-based general cancer registry in Ontario, Canada

• Open Access
• Research article