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BMC Cancer

Ausgabe 1/2016

Inhalt (948 Artikel)

Open Access Research article

A systematic review of geographical variation in access to chemotherapy

Charlotte Chamberlain, Amanda Owen-Smith, Jenny Donovan, William Hollingworth

Open Access Research article

All-trans retinoic acid synergizes with topotecan to suppress AML cells via promoting RARα-mediated DNA damage

Zhifei Xu, JinJin Shao, Lin Li, Xueming Peng, Min Chen, Guanqun Li, Hao Yan, Bo Yang, Peihua Luo, Qiaojun He

Open Access Research article

MicroRNA expression analysis in high fat diet-induced NAFLD-NASH-HCC progression: study on C57BL/6J mice

Alessandra Tessitore, Germana Cicciarelli, Filippo Del Vecchio, Agata Gaggiano, Daniela Verzella, Mariafausta Fischietti, Valentina Mastroiaco, Antonella Vetuschi, Roberta Sferra, Remo Barnabei, Daria Capece, Francesca Zazzeroni, Edoardo Alesse

Open Access Research article

Prevalence and correlates of healthy lifestyle behaviors among early cancer survivors

Iris M. Kanera, Catherine A. W. Bolman, Ilse Mesters, Roy A. Willems, Audrey A. J. M. Beaulen, Lilian Lechner

Open Access Research article

Population attributable risks of modifiable reproductive factors for breast and ovarian cancers in Korea

Boyoung Park, Sohee Park, Hai-Rim Shin, Aesun Shin, Yohwan Yeo, Ji-Yeob Choi, Kyu-Won Jung, Byoung-Gie Kim, Yong-Man Kim, Dong-Young Noh, Sei-Hyun Ahn, Jae Weon Kim, Sokbom Kang, Jae Hoon Kim, Tae Jin Kim, Daehee Kang, Keun-Young Yoo, Sue K. Park

Open Access Research article

The role of GAGE cancer/testis antigen in metastasis: the jury is still out

Morten Frier Gjerstorff, Mikkel Green Terp, Malene Bredahl Hansen, Henrik Jørn Ditzel

Open Access Erratum

Erratum to: KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin in prostate cancer models

Giovanni Luca Gravina, Andrea Mancini, Patrizia Sanita, Flora Vitale, Francesco Marampon, Luca Ventura, Yosef Landesman, Dilara McCauley, Michael Kauffman, Sharon Shacham, Claudio Festuccia

Open Access Research article

Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma

Yves-Paul Vandewynckel, Debby Laukens, Lindsey Devisscher, Eliene Bogaerts, Annelies Paridaens, Anja Van den Bussche, Sarah Raevens, Xavier Verhelst, Christophe Van Steenkiste, Bart Jonckx, Louis Libbrecht, Anja Geerts, Peter Carmeliet, Hans Van Vlierberghe

Open Access Research article

RASSF1 tumor suppressor gene in pancreatic ductal adenocarcinoma: correlation of expression, chromosomal status and epigenetic changes

Eliana Amato, Stefano Barbi, Matteo Fassan, Claudio Luchini, Caterina Vicentini, Matteo Brunelli, Giuseppe Malleo, Aldo Scarpa, Giorgio Malpeli

Open Access Research article

Lgr5 expression is a valuable prognostic factor for colorectal cancer: evidence from a meta-analysis

Yangyan Jiang, Wenlu Li, Xin He, Hongbo Zhang, Fangzhen Jiang, Zhigang Chen

Open Access Research article

GENESIS: a French national resource to study the missing heritability of breast cancer

Olga M. Sinilnikova, Marie-Gabrielle Dondon, Séverine Eon-Marchais, Francesca Damiola, Laure Barjhoux, Morgane Marcou, Carole Verny-Pierre, Valérie Sornin, Lucie Toulemonde, Juana Beauvallet, Dorothée Le Gal, Noura Mebirouk, Muriel Belotti, Olivier Caron, Marion Gauthier-Villars, Isabelle Coupier, Bruno Buecher, Alain Lortholary, Catherine Dugast, Paul Gesta, Jean-Pierre Fricker, Catherine Noguès, Laurence Faivre, Elisabeth Luporsi, Pascaline Berthet, Capucine Delnatte, Valérie Bonadona, Christine M. Maugard, Pascal Pujol, Christine Lasset, Michel Longy, Yves-Jean Bignon, Claude Adenis, Laurence Venat-Bouvet, Liliane Demange, Hélène Dreyfus, Marc Frenay, Laurence Gladieff, Isabelle Mortemousque, Séverine Audebert-Bellanger, Florent Soubrier, Sophie Giraud, Sophie Lejeune-Dumoulin, Annie Chevrier, Jean-Marc Limacher, Jean Chiesa, Anne Fajac, Anne Floquet, François Eisinger, Julie Tinat, Chrystelle Colas, Sandra Fert-Ferrer, Clotilde Penet, Thierry Frebourg, Marie-Agnès Collonge-Rame, Emmanuelle Barouk-Simonet, Valérie Layet, Dominique Leroux, Odile Cohen-Haguenauer, Fabienne Prieur, Emmanuelle Mouret-Fourme, François Cornélis, Philippe Jonveaux, Odile Bera, Eve Cavaciuti, Anne Tardivon, Fabienne Lesueur, Sylvie Mazoyer, Dominique Stoppa-Lyonnet, Nadine Andrieu

Open Access Research article

Novel polymorphisms in caspase-8 are associated with breast cancer risk in the California Teachers Study

Hannah Lui Park, Argyrios Ziogas, Jenny Chang, Bhumi Desai, Leona Bessonova, Chad Garner, Eunjung Lee, Susan L. Neuhausen, Sophia S. Wang, Huiyan Ma, Jessica Clague, Peggy Reynolds, James V. Lacey Jr, Leslie Bernstein, Hoda Anton-Culver

Open Access Research article

CD133+ liver cancer stem cells resist interferon-gamma-induced autophagy

Jian Li, Jin-Na Chen, Ting-Ting Zeng, Fan He, Shu-Peng Chen, Stephanie Ma, Jiong Bi, Xiao-Feng Zhu, Xin-Yuan Guan

Open Access Research article

Prognostic value of high FoxC2 expression in resectable non-small cell lung cancer, alone or in combination with E-cadherin expression

Wei Jiang, Hong Fan, Cheng Qian, Jianyong Ding, Qun Wang, Xuguang Pang

Open Access Research article

Silvestrol induces early autophagy and apoptosis in human melanoma cells

Wei-Lun Chen, Li Pan, A. Douglas Kinghorn, Steven M. Swanson, Joanna E. Burdette

Open Access Research article

Cetuximab plus platinum-based chemotherapy in head and neck squamous cell carcinoma: a randomized, double-blind safety study comparing cetuximab produced from two manufacturing processes using the EXTREME study regimen

Denis Soulières, Jose Luis Aguilar, Eric Chen, Krzysztof Misiukiewicz, Scott Ernst, Hyun Jung Lee, Katherine Bryant, Shuang He, Coleman K. Obasaju, Shao-Chun Chang, Steve Chin, Douglas Adkins

Open Access Research article

Prognostic value of protein inhibitor of activated STAT3 in breast cancer patients receiving hormone therapy

Sheau-Fang Yang, Ming-Feng Hou, Fang-Ming Chen, Fu Ou-Yang, Yang-Chang Wu, Chee-Yin Chai, Yao-Tsung Yeh

Open Access Research article

DocOx (AIO-PK0106): a phase II trial of docetaxel and oxaliplatin as a second line systemic therapy in patients with advanced pancreatic ductal adenocarcinoma

Thomas J. Ettrich, Lukas Perkhofer, Goetz von Wichert, Thomas M. Gress, Patrick Michl, Holger F. Hebart, Petra Büchner-Steudel, Michael Geissler, Rainer Muche, Bettina Danner, Volker Kächele, Andreas W. Berger, Melanie Güthle, Thomas Seufferlein

Open Access Research article

Correlation of KIT and PDGFRA mutational status with clinical benefit in patients with gastrointestinal stromal tumor treated with sunitinib in a worldwide treatment-use trial

Peter Reichardt, George D. Demetri, Hans Gelderblom, Piotr Rutkowski, Seock-Ah Im, Sudeep Gupta, Yoon-Koo Kang, Patrick Schöffski, Jochen Schuette, Denis Soulières, Jean-Yves Blay, David Goldstein, Kolette Fly, Xin Huang, Massimo Corsaro, Maria Jose Lechuga, Jean-Francois Martini, Michael C. Heinrich

Open Access Research article

A potent betulinic acid analogue ascertains an antagonistic mechanism between autophagy and proteasomal degradation pathway in HT-29 cells

Debasmita Dutta, Biswajit Chakraborty, Ankita Sarkar, Chinmay Chowdhury, Padma Das

Open Access Research article

FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine

Dannel Yeo, Hong He, Oneel Patel, Andrew M. Lowy, Graham S. Baldwin, Mehrdad Nikfarjam

Open Access Research article

Dronabinol has preferential antileukemic activity in acute lymphoblastic and myeloid leukemia with lymphoid differentiation patterns

Kerstin Maria Kampa-Schittenhelm, Olaf Salitzky, Figen Akmut, Barbara Illing, Lothar Kanz, Helmut Rainer Salih, Marcus Matthias Schittenhelm

Open Access Research article

Novel c-Met inhibitor suppresses the growth of c-Met-addicted gastric cancer cells

Chi Hoon Park, Sung Yun Cho, Jae Du Ha, Heejung Jung, Hyung Rae Kim, Chong Ock Lee, In-Young Jang, Chong Hak Chae, Heung Kyoung Lee, Sang Un Choi

Open Access Erratum

Erratum to: RIZ1: a potential tumor suppressor in glioma

Chenran Zhang, Qiubei Zhu, Hua He, Lei Jiang, Qiang Qiang, Liuhua Hu, Guohan Hu, Ying Jiang, Xuehua Ding, Yicheng Lu

Open Access Research article

Genetic heterogeneity of actionable genes between primary and metastatic tumor in lung adenocarcinoma

Eun Young Kim, Eun Na Cho, Heae Surng Park, Arum Kim, Ji Young Hong, Seri Lim, Jong Pil Youn, Seung Yong Hwang, Yoon Soo Chang

Open Access Research article

Mutations in TP53 increase the risk of SOX2 copy number alterations and silencing of TP53 reduces SOX2 expression in non-small cell lung cancer

Johanna Samulin Erdem, Vidar Skaug, Per Bakke, Amund Gulsvik, Aage Haugen, Shanbeh Zienolddiny

Open Access Research article

Correlation analyses between pre- and post-operative adverse events in gastric cancer patients receiving preoperative treatment and gastrectomy

Shuang-Xi Li, Sang Hyuk Seo, Yoon Young Choi, Masatoshi Nakagawa, Ji Yeong An, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Sung Hoon Noh

Open Access Research article

Trabectedin for inoperable or recurrent soft tissue sarcoma in adult patients: a retrospective cohort study

Fernando A. Angarita, Amanda J. Cannell, Albiruni R. Abdul Razak, Brendan C. Dickson, Martin E. Blackstein

Open Access Case report

(Secondary) solid tumors in thyroid cancer patients treated with the multi-kinase inhibitor sorafenib may present diagnostic challenges

Tatiana C. Schneider, Ellen Kapiteijn, Tom van Wezel, Jan W. A. Smit, Jacobus J. M. van der Hoeven, Hans Morreau

Open Access Research article

Regulatory dissection of the CBX5 and hnRNPA1 bi-directional promoter in human breast cancer cells reveals novel transcript variants differentially associated with HP1α down-regulation in metastatic cells

Johan Vad-Nielsen, Kristine Raaby Jakobsen, Tina Fuglsang Daugaard, Rune Thomsen, Anja Brügmann, Boe Sandahl Sørensen, Anders Lade Nielsen

Open Access Research article

MIR494 reduces renal cancer cell survival coinciding with increased lipid droplets and mitochondrial changes

Punashi Dutta, Edward Haller, Arielle Sharp, Meera Nanjundan

Open Access Research article

Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines

Haatisha Jandu, Kristina Aluzaite, Louise Fogh, Sebastian Wingaard Thrane, Julie B. Noer, Joanna Proszek, Khoa Nguyen Do, Stine Ninel Hansen, Britt Damsgaard, Signe Lykke Nielsen, Magnus Stougaard, Birgitta R. Knudsen, José Moreira, Petra Hamerlik, Madhavsai Gajjar, Marcel Smid, John Martens, John Foekens, Yves Pommier, Nils Brünner, Anne-Sofie Schrohl, Jan Stenvang

Open Access Research article

Clinicopathological analysis in patients with neuroendocrine tumors that metastasized to the brain

Jiro Akimoto, Hirokazu Fukuhara, Tomohiro Suda, Kenta Nagai, Megumi Ichikawa, Shinjiro Fukami, Michihiro Kohno, Jun Matsubayashi, Toshitaka Nagao

Open Access Research article

Molecular targeted photoimmunotherapy for HER2-positive human gastric cancer in combination with chemotherapy results in improved treatment outcomes through different cytotoxic mechanisms

Kimihiro Ito, Makoto Mitsunaga, Seiji Arihiro, Masayuki Saruta, Mika Matsuoka, Hisataka Kobayashi, Hisao Tajiri

Open Access Research article

LINE-1 silencing by retinoblastoma proteins is effected through the nucleosomal and remodeling deacetylase multiprotein complex

Diego E. Montoya-Durango, Kenneth A. Ramos, Pasano Bojang, Lorell Ruiz, Irma N. Ramos, Kenneth S. Ramos

Open Access Research article

Aspirin inhibits epithelial-to-mesenchymal transition and migration of oncogenic K-ras-expressing non-small cell lung carcinoma cells by down-regulating E-cadherin repressor Slug

Poulami Khan, Argha Manna, Shilpi Saha, Suchismita Mohanty, Shravanti Mukherjee, Minakshi Mazumdar, Deblina Guha, Tanya Das

Open Access Research article

Gene methylation profile of gastric cancerous tissue according to tumor site in the stomach

Rita Kupcinskaite-Noreikiene, Rasa Ugenskiene, Alius Noreika, Viktoras Rudzianskas, Jurgita Gedminaite, Jurgita Skieceviciene, Elona Juozaityte

Open Access Research article

Pre-treatment neutrophil to lymphocyte ratio predicts the chemoradiotherapy outcome and survival in patients with oral squamous cell carcinoma: a retrospective study

Hikaru Nakashima, Yuichiro Matsuoka, Ryoji Yoshida, Masashi Nagata, Akiyuki Hirosue, Kenta Kawahara, Junki Sakata, Hidetaka Arita, Akimitsu Hiraki, Hideki Nakayama

Open Access Correspondence

Asian expert recommendation on management of skin and mucosal effects of radiation, with or without the addition of cetuximab or chemotherapy, in treatment of head and neck squamous cell carcinoma

Guopei Zhu, Jin-Ching Lin, Sung-Bae Kim, Jacques Bernier, Jai Prakash Agarwal, Jan B. Vermorken, Dang Huy Quoc Thinh, Hoi-Ching Cheng, Hwan Jung Yun, Imjai Chitapanarux, Prasert Lertsanguansinchai, Vijay Anand Reddy, Xia He

Open Access Research article

Thrombocytosis and hyperfibrinogenemia are predictive factors of clinical outcomes in high-grade serous ovarian cancer patients

Zheng Feng, Hao Wen, Rui Bi, Yachen Duan, Wentao Yang, Xiaohua Wu

Open Access Research article

Impact of the introduction of EBUS on time to management decision, complications, and invasive modalities used to diagnose and stage lung cancer: a pragmatic pre-post study

Neli S. Slavova-Azmanova, Catalina Lizama, Claire E. Johnson, Herbert P. Ludewick, Leanne Lester, Shanka Karunarathne, Martin Phillips

Open Access Research article

Both Talin-1 and Talin-2 correlate with malignancy potential of the human hepatocellular carcinoma MHCC-97 L cell

Kun-peng Fang, Wei Dai, Yan-Hong Ren, Ye-Chuan Xu, She-min Zhang, Ye-Ben Qian

Open Access Research article

Long-term use of lenalidomide and low-dose dexamethasone in Chinese patients with relapsed/refractory multiple myeloma: MM-024 Extended Access Program

Xin Du, Jie Jin, Zhen Cai, Fangping Chen, Dao-bin Zhou, Li Yu, Xiaoyan Ke, Xiao Li, Depei Wu, Fanyi Meng, Dena DeMarco, Jingshan Zhang, Jay Mei, Jian Hou

Open Access Research article

Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer

Ryan A. Denu, Lauren M. Zasadil, Craig Kanugh, Jennifer Laffin, Beth A. Weaver, Mark E. Burkard

Open Access Research article

Cancer survival in New South Wales, Australia: socioeconomic disparities remain despite overall improvements

Julia F. Stanbury, Peter D. Baade, Yan Yu, Xue Qin Yu

Open Access Research article

The dual specificity phosphatase 2 gene is hypermethylated in human cancer and regulated by epigenetic mechanisms

Tanja Haag, Antje M. Richter, Martin B. Schneider, Adriana P. Jiménez, Reinhard H. Dammann

Open Access Research article

US-localized diffuse optical tomography in breast cancer: comparison with pharmacokinetic parameters of DCE-MRI and with pathologic biomarkers

Min Jung Kim, Min-Ying Su, Hon J Yu, Jeon-Hor Chen, Eun-Kyung Kim, Hee Jung Moon, Ji Soo Choi

Open Access Research article

Low oxygen tension reverses antineoplastic effect of iron chelator deferasirox in human glioblastoma cells

Claire Legendre, Sylvie Avril, Catherine Guillet, Emmanuel Garcion

Open Access Research article

Associations of microbiota and toll-like receptor signaling pathway in esophageal adenocarcinoma

Ali H. Zaidi, Lori A. Kelly, Rachael E. Kreft, Mark Barlek, Ashten N. Omstead, Daisuke Matsui, Natalie H. Boyd, Kathryn E. Gazarik, Megan I. Heit, Laura Nistico, Pashtoon M. Kasi, Tracy L. Spirk, Barbara Byers, Emily J. Lloyd, Rodney J. Landreneau, Blair A. Jobe

Open Access Research article

Cooperation of Sox4 with β-catenin/p300 complex in transcriptional regulation of the Slug gene during divergent sarcomatous differentiation in uterine carcinosarcoma

Hisako Inoue, Hiroyuki Takahashi, Miki Hashimura, Koji Eshima, Masashi Akiya, Toshihide Matsumoto, Makoto Saegusa

Open Access Research article

Establishment and characterization of a metastasis model of human gastric cancer in nude mice

Kesheng Li, Huifen Du, Xiaowen Lian, Dandan Chai, Xinwen Li, Rong Yang, Chunya Wang

Open Access Research article

Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility

Hui-min Zhou, Yuan-yuan Fang, Paul M. Weinberger, Ling-ling Ding, John K. Cowell, Farlyn Z. Hudson, Mingqiang Ren, Jeffrey R. Lee, Qi-kui Chen, Hong Su, William S. Dynan, Ying Lin

Open Access Research article

Fusion with stem cell makes the hepatocellular carcinoma cells similar to liver tumor-initiating cells

Ran Wang, Shuxun Chen, Changxian Li, Kevin Tak Pan Ng, Chi-wing Kong, Jinping Cheng, Shuk Han Cheng, Ronald A. Li, Chung Mau Lo, Kwan Man, Dong Sun

Open Access Research article

Cancer risk in East Asian patients associated with acquired haemolytic anaemia: a nationwide population-based cohort study

Victor C. Kok, Fung-Chang Sung, Chia-Hung Kao, Che-Chen Lin, Chun-Hung Tseng

Open Access Research article

Dietary leucine supplementation minimises tumour-induced damage in placental tissues of pregnant, tumour-bearing rats

Bread Leandro Gomes Cruz, Priscila Cristina da Silva, Rebeka Tomasin, Andre Gustavo Oliveira, Lais Rosa Viana, Emilianne Miguel Salomao, Maria Cristina Cintra Gomes-Marcondes

Open Access Research article

Metabolic syndrome diagnosis and widespread high grade prostatic intraepithelial neoplasia significantly increase prostate cancer risk: results from a multicenter biopsy study

Antonio Cicione, Cosimo De Nunzio, Andrea Tubaro, Francesco Cantiello, Stefano Manno, Carlos Oliveira, Estevao Lima, Rocco Damiano

Open Access Research article

Differences in TGF-β1 signaling and clinicopathologic characteristics of histologic subtypes of gastric cancer

Kyung Ho Pak, Dong Hoon Kim, Hyunki Kim, Do Hyung Lee, Jae-Ho Cheong

Open Access Research article

Feasibility outcomes of a presurgical randomized controlled trial exploring the impact of caloric restriction and increased physical activity versus a wait-list control on tumor characteristics and circulating biomarkers in men electing prostatectomy for prostate cancer

Wendy Demark-Wahnefried, Jeffery W. Nix, Gary R. Hunter, Soroush Rais-Bahrami, Renee A. Desmond, Balu Chacko, Casey D. Morrow, Maria Azrad, Andrew D. Frugé, Yuko Tsuruta, Travis Ptacek, Scott A. Tully, Roanne Segal, William E. Grizzle

Open Access Case report

Metastatic EML4-ALK fusion detected by circulating DNA genotyping in an EGFR-mutated NSCLC patient and successful management by adding ALK inhibitors: a case report

Wenhua Liang, Qihua He, Ying Chen, Shaokun Chuai, Weiqiang Yin, Wei Wang, Guilin Peng, Caicun Zhou, Jianxing He

Open Access Research article

High mannose-binding Pseudomonas fluorescens lectin (PFL) downregulates cell surface integrin/EGFR and induces autophagy in gastric cancer cells

Yuichiro Sato, Takanori Kubo, Kinjiro Morimoto, Kazuyoshi Yanagihara, Toshio Seyama

Open Access Research article

Novel germline mutations and unclassified variants of BRCA1 and BRCA2 genes in Chinese women with familial breast/ovarian cancer

Wen-Ming Cao, Yun Gao, Hong-Jian Yang, Shang-Nao Xie, Xiao-Wen Ding, Zhi-Wen Pan, Wei-Wu Ye, Xiao-Jia Wang

Open Access Research article

Pitfalls of practicing cancer epidemiology in resource-limited settings: the case of survival and loss to follow-up after a diagnosis of Kaposi’s sarcoma in five countries across sub-Saharan Africa

Esther Freeman, Aggrey Semeere, Megan Wenger, Mwebesa Bwana, F. Chite Asirwa, Naftali Busakhala, Emmanuel Oga, Elima Jedy-Agba, Vivian Kwaghe, Kenneth Iregbu, Antoine Jaquet, Francois Dabis, Habakkuk Azinyui Yumo, Jean Claude Dusingize, David Bangsberg, Kathryn Anastos, Sam Phiri, Julia Bohlius, Matthias Egger, Constantin Yiannoutsos, Kara Wools-Kaloustian, Jeffrey Martin

Open Access Research article

Scenario drafting for early technology assessment of next generation sequencing in clinical oncology

S.E.P. Joosten, V.P. Retèl, V.M.H. Coupé, M.M. van den Heuvel, W.H. van Harten

Open Access Research article

FDG PET/CT as a prognostic biomarker in the era of molecular-targeting therapies: max SUVmax predicts survival of patients with advanced renal cell carcinoma

Noboru Nakaigawa, Keiichi Kondo, Ukihide Tateishi, Ryogo Minamimoto, Tomohiro Kaneta, Kazuhiro Namura, Daiki Ueno, Kazuki Kobayashi, Takeshi Kishida, Ichiro Ikeda, Hisashi Hasumi, Kazuhide Makiyama, Yoshinobu Kubota, Tomio Inoue, Masahiro Yao

Open Access Research article

Optimal regimen of trastuzumab in combination with oxaliplatin/ capecitabine in first-line treatment of HER2-positive advanced gastric cancer (CGOG1001): a multicenter, phase II trial

Jifang Gong, Tianshu Liu, Qingxia Fan, Li Bai, Feng Bi, Shukui Qin, Jinwan Wang, Nong Xu, Ying Cheng, Yuxian Bai, Wei Liu, Liwei Wang, Lin Shen

Open Access Study protocol

A randomized phase 3 study on the optimization of the combination of bevacizumab with FOLFOX/OXXEL in the treatment of patients with metastatic colorectal cancer-OBELICS (Optimization of BEvacizumab scheduLIng within Chemotherapy Scheme)

Antonio Avallone, Maria Carmela Piccirillo, Luigi Aloj, Guglielmo Nasti, Paolo Delrio, Francesco Izzo, Elena Di Gennaro, Fabiana Tatangelo, Vincenza Granata, Ernesta Cavalcanti, Piera Maiolino, Francesco Bianco, Pasquale Aprea, Mario De Bellis, Biagio Pecori, Gerardo Rosati, Chiara Carlomagno, Alessandro Bertolini, Ciro Gallo, Carmela Romano, Alessandra Leone, Corradina Caracò, Elisabetta de Lutio di Castelguidone, Gennaro Daniele, Orlando Catalano, Gerardo Botti, Antonella Petrillo, Giovanni M. Romano, Vincenzo R. Iaffaioli, Secondo Lastoria, Francesco Perrone, Alfredo Budillon

Open Access Research article

The MYCN-HMGA2-CDKN2A pathway in non-small cell lung carcinoma—differences in histological subtypes

Hanne A. Eide, Ann Rita Halvorsen, Maria Moksnes Bjaanæs, Hossein Piri, Ruth Holm, Steinar Solberg, Lars Jørgensen, Odd Terje Brustugun, Cecilie Essholt Kiserud, Åslaug Helland

Open Access Research article

Site disparities in apoptotic variants as predictors of risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck

Yan Sun, Wenbin Yu, Erich M. Sturgis, Wei Peng, Dapeng Lei, Qingyi Wei, Xicheng Song, Guojun Li

Open Access Research article

Evaluation of TgH(CX3CR1-EGFP) mice implanted with mCherry-GL261 cells as an in vivo model for morphometrical analysis of glioma-microglia interaction

Fernando F. B. Resende, Xianshu Bai, Elaine Aparecida Del Bel, Frank Kirchhoff, Anja Scheller, Ricardo Titze-de-Almeida

Open Access Research article

Computerized tomography angiography in preoperative assessment of intravenous leiomyomatosis extending to inferior vena cava and heart

Ting Gui, Qiuhong Qian, Dongyan Cao, Jiaxin Yang, Ping Peng, Keng Shen

Open Access Research article

A pharmacogenetic pilot study reveals MTHFR, DRD3, and MDR1 polymorphisms as biomarker candidates for slow atorvastatin metabolizers

Rafael B. R. León-Cachón, Jorge A. Ascacio-Martínez, María E. Gamino-Peña, Ricardo M. Cerda-Flores, Irene Meester, Hugo L. Gallardo-Blanco, Magdalena Gómez-Silva, Everardo Piñeyro-Garza, Hugo A. Barrera-Saldaña

Open Access Review

Molecular pathways leading to loss of skeletal muscle mass in cancer cachexia – can findings from animal models be translated to humans?

Tara C. Mueller, Jeannine Bachmann, Olga Prokopchuk, Helmut Friess, Marc E. Martignoni

Open Access Research article

Using gene expression from urine sediment to diagnose prostate cancer: development of a new multiplex mRNA urine test and validation of current biomarkers

Lourdes Mengual, Juan José Lozano, Mercedes Ingelmo-Torres, Laura Izquierdo, Mireia Musquera, María José Ribal, Antonio Alcaraz

Open Access Research article

Prediction of anticancer molecules using hybrid model developed on molecules screened against NCI-60 cancer cell lines

Harinder Singh, Rahul Kumar, Sandeep Singh, Kumardeep Chaudhary, Ankur Gautam, Gajendra P. S. Raghava

Open Access Research article

Tumor slice culture system to assess drug response of primary breast cancer

Kishan A. T. Naipal, Nicole S. Verkaik, Humberto Sánchez, Carolien H. M. van Deurzen, Michael A. den Bakker, Jan H.J. Hoeijmakers, Roland Kanaar, Maaike P.G. Vreeswijk, Agnes Jager, Dik C. van Gent

Open Access Research article

Evaluating early response of cervical cancer under concurrent chemo-radiotherapy by intravoxel incoherent motion MR imaging

Li Zhu, Lijing Zhu, Hua Shi, Huanhuan Wang, Jing Yan, Baorui Liu, Weibo Chen, Jian He, Zhengyang Zhou, Xiaofeng Yang, Tian Liu

Open Access Research article

Inflammatory biomarker score and cancer: A population-based prospective cohort study

Leavitt Morrison, Jari A. Laukkanen, Kimmo Ronkainen, Sudhir Kurl, Jussi Kauhanen, Adetunji T. Toriola

Open Access Research article

Chemotherapy with BCNU in recurrent glioma: Analysis of clinical outcome and side effects in chemotherapy-naïve patients

Christine Jungk, Despina Chatziaslanidou, Rezvan Ahmadi, David Capper, Justo Lorenzo Bermejo, Janina Exner, Andreas von Deimling, Christel Herold-Mende, Andreas Unterberg

Open Access Research article

Capecitabine in the routine first-line treatment of elderly patients with advanced colorectal cancer - results from a non-interventional observation study

Alexander Stein, Julia Quidde, Jan Klaus Schröder, Thomas Göhler, Barbara Tschechne, Annette-Rosel Valdix, Heinz-Gert Höffkes, Silke Schirrmacher-Memmel, Tim Wohlfarth, Axel Hinke, Andreas Engelen, Dirk Arnold

Open Access Research article

Lack of association between polymorphisms in the CYP1A2 gene and risk of cancer: evidence from meta-analyses

Vladimir Vukovic, Carolina Ianuale, Emanuele Leoncini, Roberta Pastorino, Maria Rosaria Gualano, Rosarita Amore, Stefania Boccia

Open Access Research article

Impact of Bevacizumab on parenchymal damage and functional recovery of the liver in patients with colorectal liver metastases

Andreas M. Volk, Johannes Fritzmann, Christoph Reissfelder, Georg F. Weber, Jürgen Weitz, Nuh N. Rahbari

Open Access Research article

HOX transcription factors are potential targets and markers in malignant mesothelioma

Richard Morgan, Guy Simpson, Sophie Gray, Cheryl Gillett, Zsuzsanna Tabi, James Spicer, Kevin J. Harrington, Hardev S. Pandha

Open Access Research article

Regulation of the tumour suppressor PDCD4 by miR-499 and miR-21 in oropharyngeal cancers

Xiaoying Zhang, Harriet Gee, Barbara Rose, C. Soon Lee, Jonathan Clark, Michael Elliott, Jennifer R. Gamble, Murray J. Cairns, Adrian Harris, Samantha Khoury, Nham Tran

Open Access Research article

Parallelism of DOG1 expression with recurrence risk in gastrointestinal stromal tumors bearing KIT or PDGFRA mutations

Francesca Maria Rizzo, Raffaele Palmirotta, Andrea Marzullo, Nicoletta Resta, Mauro Cives, Marco Tucci, Franco Silvestris

Open Access Research article

Distinct genomic and epigenomic features demarcate hypomethylated blocks in colon cancer

Mahfuza Sharmin, Héctor Corrada Bravo, Sridhar Hannenhalli

Open Access Research article

Comparative immunogenicity and structural analysis of epitopes of different bacterial L-asparaginases

Vadim S. Pokrovsky, Marat D. Kazanov, Ilya N. Dyakov, Marina V. Pokrovskaya, Svetlana S. Aleksandrova

Open Access Research article

Establishment of a patient-derived intrahepatic cholangiocarcinoma xenograft model with KRAS mutation

Giuliana Cavalloni, Caterina Peraldo-Neia, Francesco Sassi, Giovanna Chiorino, Ivana Sarotto, Massimo Aglietta, Francesco Leone

Open Access Study protocol

A phase II study of Epirubicin in oxaliplatin-resistant patients with metastatic colorectal cancer and TOP2A gene amplification

Line S. Tarpgaard, Camilla Qvortrup, Sune B. Nygård, Signe L. Nielsen, Diana R. Andersen, Niels Frank Jensen, Jan Stenvang, Sönke Detlefsen, Nils Brünner, Per Pfeiffer

Open Access Research article

A nomogram for predicting the likelihood of lymph node metastasis in early gastric patients

Zhixue Zheng, Yinan Zhang, Lianhai Zhang, Ziyu Li, Xiaojiang Wu, Yiqiang Liu, Zhaode Bu, Jiafu Ji

Open Access Research article

Effects of receptor for advanced glycation endproducts on microvessel formation in endometrial cancer

Lu Zheng, Da Li, Yi-Ming Zhou, Hui Yang, Di Cheng, Xiao-Xin Ma

Open Access Research article

Organic Cation Transporter 1 (OCT1) mRNA expression in hepatocellular carcinoma as a biomarker for sorafenib treatment

Daniel Grimm, Jonas Lieb, Veronika Weyer, Johanna Vollmar, Felix Darstein, Anja Lautem, Maria Hoppe-Lotichius, Sandra Koch, Arno Schad, Jörn M. Schattenberg, Marcus A. Wörns, Arndt Weinmann, Peter R. Galle, Tim Zimmermann

Open Access Research article

Select Bcl-2 antagonism restores chemotherapy sensitivity in high-risk neuroblastoma

Rachel Tanos, Dipan Karmali, Srilatha Nalluri, Kelly C. Goldsmith

Open Access Research article

Follicular thyroid carcinoma but not adenoma recruits tumor-associated macrophages by releasing CCL15

Feng-Jiao Huang, Xiao-Yi Zhou, Lei Ye, Xiao-Chun Fei, Shu Wang, Weiqing Wang, Guang Ning

Open Access Erratum

Erratum to: Differences in TGF-β1 signaling and clinicopathologic characteristics of histologic subtypes of gastric cancer

Kyung Ho Pak, Dong Hoon Kim, Hyunki Kim, Do Hyung Lee, Jae-Ho Cheong

Open Access Reviewer Acknowledgement

BMC Cancer reviewer acknowledgement 2015

Dafne Solera

Open Access Research article

MiR-193b promotes autophagy and non-apoptotic cell death in oesophageal cancer cells

Michelle J. Nyhan, Tracey R. O’Donovan, Antonius W. M. Boersma, Erik A. C. Wiemer, Sharon L. McKenna

Open Access Research article

Expression and promotor hypermethylation of miR-34a in the various histological subtypes of ovarian cancer

Gabriel Schmid, Sara Notaro, Daniel Reimer, Samira Abdel-Azim, Michaela Duggan-Peer, Jessica Holly, Heidi Fiegl, Julia Rössler, Annemarie Wiedemair, Nicole Concin, Peter Altevogt, Christian Marth, Alain Gustave Zeimet

Open Access Research article

RETRACTED ARTICLE: BCORL1 is an independent prognostic marker and contributes to cell migration and invasion in human hepatocellular carcinoma

Guozhi Yin, Zhikui Liu, Yufeng Wang, Changwei Dou, Chao Li, Wei Yang, Yingmin Yao, Qingguang Liu, Kangsheng Tu

Open Access Research article

Epidemiology of childhood and adolescent cancer in Bangladesh, 2001–2014

Mohammad Sorowar Hossain, Mamtaz Begum, Md Mahmuduzzaman Mian, Shameema Ferdous, Shahinur Kabir, Humayun Kabir Sarker, Sabina Karim, Salma Choudhury, Asaduzzaman Khan, Zohora Jameela Khan, Henrike E. Karim-Kos

Open Access Research article

Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification

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Open Access Research article

Isolated tumor cells in stage I & II colon cancer patients are associated with significantly worse disease-free and overall survival

B. Weixler, R. Warschkow, U. Güller, A. Zettl, U. von Holzen, B. M. Schmied, M. Zuber

Open Access Research article

MiRNA-146b-5p upregulates migration and invasion of different Papillary Thyroid Carcinoma cells

Cilene Rebouças Lima, Murilo Vieira Geraldo, Cesar Seigi Fuziwara, Edna Teruko Kimura, Marinilce Fagundes Santos

Open Access Research article

Prognostic value of a computer-aided diagnosis system involving bone scans among men treated with docetaxel for metastatic castration-resistant prostate cancer

Koichi Uemura, Yasuhide Miyoshi, Takashi Kawahara, Shuko Yoneyama, Yusuke Hattori, Jun-ichi Teranishi, Keiichi Kondo, Masatoshi Moriyama, Shigeo Takebayashi, Yumiko Yokomizo, Masahiro Yao, Hiroji Uemura, Kazumi Noguchi

Open Access Research article

Bevacizumab for metachronous metastatic colorectal cancer: a reflection of community based practice

L. G. E. M. Razenberg, Y. R. B. M. van Gestel, I. H. J. T. de Hingh, O. J. L. Loosveld, G. Vreugdenhil, L. V. Beerepoot, G. J. Creemers, V. E. P. P. Lemmens

Open Access Research article

Pretreatment neutrophil-to-lymphocyte ratio predicts the prognosis in patients with metastatic prostate cancer

Takashi Kawahara, Yumiko Yokomizo, Yusuke Ito, Hiroki Ito, Hitoshi Ishiguro, Jun-ichi Teranishi, Kazuhide Makiyama, Yasuhide Miyoshi, Hiroshi Miyamoto, Masahiro Yao, Hiroji Uemura

Open Access Research article

Characterising timing and pattern of relapse following surgery for localised oesophagogastric adenocarcinoma: a retrospective study

Sing Yu Moorcraft, Elisa Fontana, David Cunningham, Clare Peckitt, Tom Waddell, Elizabeth C. Smyth, William Allum, Jeremy Thompson, Sheela Rao, David Watkins, Naureen Starling, Ian Chau

Open Access Research article

Promoter methylation of ITF2, but not APC, is associated with microsatellite instability in two populations of colorectal cancer patients

Andrea J. Savio, Darshana Daftary, Elizabeth Dicks, Daniel D. Buchanan, Patrick S. Parfrey, Joanne P. Young, Daniel Weisenberger, Roger C. Green, Steven Gallinger, John R. McLaughlin, Julia A. Knight, Bharati Bapat

Open Access Research article

Prognostic value of the distance between the primary tumor and brainstem in the patients with locally advanced nasopharyngeal carcinoma

Yuxiang He, Ying Wang, Lin Shen, Yajie Zhao, Pengfei Cao, Mingjun Lei, Dengming Chen, Tubao Yang, Liangfang Shen, Shousong Cao

Open Access Technical advance

MB3W1 is an orthotopic xenograft model for anaplastic medulloblastoma displaying cancer stem cell- and Group 3-properties

Sebastian Dietl, Stefanie Schwinn, Susanne Dietl, Simone Riedel, Frank Deinlein, Stefan Rutkowski, Andre O. von Bueren, Jürgen Krauss, Tilmann Schweitzer, Giles H. Vince, Daniel Picard, Matthias Eyrich, Andreas Rosenwald, Vijay Ramaswamy, Michael D. Taylor, Marc Remke, Camelia M. Monoranu, Andreas Beilhack, Paul G. Schlegel, Matthias Wölfl

Open Access Research article

Predictive and prognostic value of PET/CT imaging post-chemoradiotherapy and clinical decision-making consequences in locally advanced head & neck squamous cell carcinoma: a retrospective study

Ryul Kim, Chan-Young Ock, Bhumsuk Keam, Tae Min Kim, Jin Ho Kim, Jin Chul Paeng, Seong Keun Kwon, J. Hun Hah, Tack-Kyun Kwon, Dong-Wan Kim, Hong-Gyun Wu, Myung-Whun Sung, Dae Seog Heo

Open Access Erratum

Erratum to: Results of multicenter double-blind placebo-controlled phase II clinical trial of Panagen preparation to evaluate its leukostimulatory activity and formation of the adaptive immune response in patients with stage II-IV breast cancer

Anastasia S. Proskurina, Tatiana S. Gvozdeva, Ekaterina A. Alyamkina, Evgenia V. Dolgova, Konstantin E. Orishchenko, Valeriy P. Nikolin, Nelly A. Popova, Sergey V. Sidorov, Elena R. Chernykh, Alexandr A. Ostanin, Olga Y. Leplina, Victoria V. Dvornichenko, Dmitriy M. Ponomarenko, Galina S. Soldatova, Nikolay A. Varaksin, Tatiana G. Ryabicheva, Peter N. Uchakin, Stanislav N. Zagrebelniy, Vladimir A. Rogachev, Sergey S. Bogachev, Mikhail A. Shurdov

Open Access Case report

Paraneoplastic lipase and amylase production in a patient with small-cell lung cancer: case report

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Open Access Research article

Breast cancer literacy among higher secondary students: results from a cross-sectional study in Western Nepal

Parash Mani Bhandari, Kiran Thapa, Sarmila Dhakal, Shristi Bhochhibhoya, Rashmi Deuja, Pawan Acharya, Shiva Raj Mishra

Open Access Research article

The impact of KRAS mutations on prognosis in surgically resected colorectal cancer patients with liver and lung metastases: a retrospective analysis

Hae Su Kim, Jin Seok Heo, Jeeyun Lee, Ji Yun Lee, Min-Young Lee, Sung Hee Lim, Woo Yong Lee, Seok Hyung Kim, Yoon Ah Park, Yong Beom Cho, Seong Hyeon Yun, Seung Tae Kim, Joon Oh Park, Ho Yeong Lim, Yong Soo Choi, Woo Il Kwon, Hee Cheol Kim, Young Suk Park

Open Access Research article

Phase II study on the efficacy and safety of Lapatinib administered beyond disease progression and combined with vinorelbine in HER-2/neu– positive advanced breast cancer: results of the CECOG LaVie trial

Christiane Thallinger, Istvan Lang, Cvetka Grasic Kuhar, Rupert Bartsch, Christian F. Singer, Lubos Petruzelka, Bohuslav Melichar, Regina Knittelfelder, Thomas Brodowicz, Christoph Zielinski

Open Access Research article

Methodology of health-related quality of life analysis in phase III advanced non-small-cell lung cancer clinical trials: a critical review

Frédéric Fiteni, Amélie Anota, Virginie Westeel, Franck Bonnetain

Open Access Research article

An 8-gene mRNA expression profile in circulating tumor cells predicts response to aromatase inhibitors in metastatic breast cancer patients

Esther A. Reijm, Anieta M. Sieuwerts, Marcel Smid, Joan Bolt-de Vries, Bianca Mostert, Wendy Onstenk, Dieter Peeters, Luc Y. Dirix, Caroline M. Seynaeve, Agnes Jager, Felix E. de Jongh, Paul Hamberg, Anne van Galen, Jaco Kraan, Maurice P. H. M. Jansen, Jan W. Gratama, John A. Foekens, John W. M. Martens, Els M. J. J. Berns, Stefan Sleijfer

Open Access Research article

Systemic inflammation is an independent predictive marker of clinical outcomes in mucosal squamous cell carcinoma of the head and neck in oropharyngeal and non-oropharyngeal patients

Kellie A. Charles, Benjamin D. W. Harris, Carol R. Haddad, Stephen J. Clarke, Alex Guminski, Mark Stevens, Tristan Dodds, Anthony J. Gill, Michael Back, David Veivers, Thomas Eade

Open Access Research article

Prolonged pemetrexed pretreatment augments persistence of cisplatin-induced DNA damage and eliminates resistant lung cancer stem-like cells associated with EMT

Colin Charles Tièche, Ren-Wang Peng, Patrick Dorn, Laurène Froment, Ralph Alexander Schmid, Thomas Michael Marti

Open Access Research article

Combination of metformin and 5-aminosalicylic acid cooperates to decrease proliferation and induce apoptosis in colorectal cancer cell lines

Mona M. Saber, May A. Galal, Afaf A. Ain-Shoka, Samia A. Shouman

Open Access Research article

CXCR4-SDF-1 interaction potentially mediates trafficking of circulating tumor cells in primary breast cancer

M. Mego, D. Cholujova, G. Minarik, T. Sedlackova, P. Gronesova, M. Karaba, J. Benca, S. Cingelova, Z. Cierna, D. Manasova, D. Pindak, J. Sufliarsky, M. Cristofanilli, J. M. Reuben, J. Mardiak

Open Access Research article

Prognostic value of the bone scan index using a computer-aided diagnosis system for bone scans in hormone-naive prostate cancer patients with bone metastases

Yasuhide Miyoshi, Shuko Yoneyama, Takashi Kawahara, Yusuke Hattori, Jun-ichi Teranishi, Keiichi Kondo, Masatoshi Moriyama, Shigeo Takebayashi, Yumiko Yokomizo, Masahiro Yao, Hiroji Uemura, Kazumi Noguchi

Open Access Research article

Stage of breast cancer at diagnosis in New Zealand: impacts of socio-demographic factors, breast cancer screening and biology

Sanjeewa Seneviratne, Ross Lawrenson, Vernon Harvey, Reena Ramsaroop, Mark Elwood, Nina Scott, Diana Sarfati, Ian Campbell

Open Access Case report

Pancreatic panniculitis in a patient with pancreatic-type acinar cell carcinoma of the liver – case report and review of literature

Sebastian Zundler, Ramona Erber, Abbas Agaimy, Arndt Hartmann, Franklin Kiesewetter, Deike Strobel, Markus F. Neurath, Dane Wildner

Open Access Research article

A novel anti-p21Ras scFv antibody reacting specifically with human tumour cell lines and primary tumour tissues

Ju-Lun Yang, Du-Xian Liu, Shi-Jian Zhen, Yun-Gang Zhou, Dai-Jun Zhang, Li-Ying Yang, Hao-Bing Chen, Qiang Feng

Open Access Study protocol

TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC trial): study protocol for a randomized controlled trial

M. M. Koeneman, A. J. Kruse, L. F. S. Kooreman, A. zur Hausen, A. H. N. Hopman, S. J. S. Sep, T. Van Gorp, B. F. M. Slangen, H. J. van Beekhuizen, M. van de Sande, C. G. Gerestein, H. W. Nijman, R. F. P. M. Kruitwagen

Open Access Research article

Associations between metabolic disorders and risk of cancer in Danish men and women – a nationwide cohort study

Siv Mari Berger, Gunnar Gislason, Lynn L. Moore, Charlotte Andersson, Christian Torp-Pedersen, Gerald V. Denis, Michelle Dalgas Schmiegelow

Open Access Research article

Transketolase-like 1 ectopic expression is associated with DNA hypomethylation and induces the Warburg effect in melanoma cells

Aparna Jayachandran, Pu-Han Lo, Anderly C. Chueh, Prashanth Prithviraj, Ramyar Molania, Mercedes Davalos-Salas, Matthew Anaka, Marzena Walkiewicz, Jonathan Cebon, Andreas Behren

Open Access Research article

Impact on clinical practice of the implementation of guidelines for the toxicity management of targeted therapies in kidney cancer. The protect-2 study

Nuria Lainez, Jesús García-Donas, Emilio Esteban, Javier Puente, M. Isabel Sáez, Enrique Gallardo, Álvaro Pinto-Marín, Sergio Vázquez-Estévez, Luis León, Icíar García-Carbonero, Cristina Suárez-Rodríguez, Carmen Molins, Miguel A. Climent-Duran, Martín Lázaro-Quintela, Aranzazu González del Alba, María José Méndez-Vidal, Isabel Chirivella, Francisco J. Afonso, Marta López-Brea, Nuria Sala-González, Montserrat Domenech, Laura Basterretxea, Carmen Santander-Lobera, Irene Gil-Arnáiz, Ovidio Fernández, Cristina Caballero-Díaz, Begoña Mellado, David Marrupe, José García-Sánchez, Ricardo Sánchez-Escribano, Eva Fernández Parra, José C. Villa Guzmán, Esther Martínez-Ortega, María Belén González, Marina Morán, Beatriz Suarez-Paniagua, María J. Lecumberri, Daniel Castellano

Open Access Research article

A novel and accurate predictor of survival for patients with hepatocellular carcinoma after surgical resection: the neutrophil to lymphocyte ratio (NLR) combined with the aspartate aminotransferase/platelet count ratio index (APRI)

Fei Ji, Yao Liang, Shun-Jun Fu, Zhi-Yong Guo, Man Shu, Shun-Li Shen, Shao-Qiang Li, Bao-Gang Peng, Li-Jian Liang, Yun-Peng Hua

Open Access Research article

Prognostic value of ERBB4 expression in patients with triple negative breast cancer

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Open Access Research article

Impact of postoperative daily image-guided intensity-modulated radiotherapy on overall and local progression-free survival in patients with oral cavity cancer

Chen-Hsi Hsieh, Pei-Wei Shueng, Li-Ying Wang, Yu-Chuen Huang, Li-Jen Liao, Wu-Chia Lo, Yu-Chin Lin, Le-Jung Wu, Hui-Ju Tien

Open Access Research article

Platinum (IV)-fatty acid conjugates overcome inherently and acquired Cisplatin resistant cancer cell lines: an in-vitro study

Einav Ratzon, Yousef Najajreh, Rami Salem, Hazem Khamaisie, Martin Ruthardt, Jamal Mahajna

Open Access Research article

IκBα mediates prostate cancer cell death induced by combinatorial targeting of the androgen receptor

Sarah L. Carter, Margaret M. Centenera, Wayne D. Tilley, Luke A. Selth, Lisa M. Butler

Open Access Technical advance

Generation of an algorithm based on minimal gene sets to clinically subtype triple negative breast cancer patients

Brian Z. Ring, David R. Hout, Stephan W. Morris, Kasey Lawrence, Brock L. Schweitzer, Daniel B. Bailey, Brian D. Lehmann, Jennifer A. Pietenpol, Robert S. Seitz

Open Access Research article

Intraoperative optical coherence tomography for assessing human lymph nodes for metastatic cancer

Ryan M. Nolan, Steven G. Adie, Marina Marjanovic, Eric J. Chaney, Fredrick A. South, Guillermo L. Monroy, Nathan D. Shemonski, Sarah J. Erickson-Bhatt, Ryan L. Shelton, Andrew J. Bower, Douglas G. Simpson, Kimberly A. Cradock, Z. George Liu, Partha S. Ray, Stephen A. Boppart

Open Access Research article

Breast cancer stem cell selectivity of synthetic nanomolar-active salinomycin analogs

Xiaoli Huang, Björn Borgström, Sebastian Kempengren, Lo Persson, Cecilia Hegardt, Daniel Strand, Stina Oredsson

Open Access Research article

RNA disruption is associated with response to multiple classes of chemotherapy drugs in tumor cell lines

Rashmi Narendrula, Kyle Mispel-Beyer, Baoqing Guo, Amadeo M. Parissenti, Laura B. Pritzker, Ken Pritzker, Twinkle Masilamani, Xiaohui Wang, Carita Lannér

Open Access Research article

Distribution and prognosis of uncommon metastases from non-small cell lung cancer

Fei-Yu Niu, Qing Zhou, Jin-Ji Yang, Wen-Zhao Zhong, Zhi-Hong Chen, Wei Deng, Yan-Yan He, Hua-Jun Chen, Zhu Zeng, E-E Ke, Ning Zhao, Na Zhang, Hui-Wen Sun, Qiu-Yi Zhang, Zhi Xie, Xu-Chao Zhang, Yi-Long Wu

Open Access Research article

Cyclopamine tartrate, an inhibitor of Hedgehog signaling, strongly interferes with mitochondrial function and suppresses aerobic respiration in lung cancer cells

Md Maksudul Alam, Sagar Sohoni, Sarada Preeta Kalainayakan, Massoud Garrossian, Li Zhang

Open Access Research article

Genetic and cellular studies highlight that A Disintegrin and Metalloproteinase 19 is a protective biomarker in human prostate cancer

Gerard Hoyne, Caroline Rudnicka, Qing-Xiang Sang, Mark Roycik, Sarah Howarth, Peter Leedman, Markus Schlaich, Patrick Candy, Vance Matthews

Open Access Research article

Molecular association of glucose-6-phosphate isomerase and pyruvate kinase M2 with glyceraldehyde-3-phosphate dehydrogenase in cancer cells

Mahua R. Das, Arup K. Bag, Shekhar Saha, Alok Ghosh, Sumit K. Dey, Provas Das, Chitra Mandal, Subhankar Ray, Saikat Chakrabarti, Manju Ray, Siddhartha S. Jana

Open Access Research article

A phase 1b study of Selumetinib in combination with Cisplatin and Gemcitabine in advanced or metastatic biliary tract cancer: the ABC-04 study

John Bridgewater, Andre Lopes, Sandra Beare, Marian Duggan, Dymphna Lee, Maravic Ricamara, Delyth McEntee, Ajithkumar Sukumaran, Harpreet Wasan, Juan W. Valle

Open Access Research article

Evaluation of serum and tissue levels of VAP-1 in colorectal cancer

Stephen T. Ward, Christopher J. Weston, Emma L. Shepherd, Rahul Hejmadi, Tariq Ismail, David H. Adams

Open Access Research article

The anti-oxidative transcription factor Nuclear factor E2 related factor-2 (Nrf2) counteracts TGF-β1 mediated growth inhibition of pancreatic ductal epithelial cells -Nrf2 as determinant of pro-tumorigenic functions of TGF-β1

Geeske Genrich, Marcus Kruppa, Lennart Lenk, Ole Helm, Anna Broich, Sandra Freitag-Wolf, Christoph Röcken, Bence Sipos, Heiner Schäfer, Susanne Sebens

Open Access Research article

Correlation between S-1 treatment outcome and expression of biomarkers for refractory thymic carcinoma

Yusuke Okuma, Yukio Hosomi, Shingo Miyamoto, Masahiko Shibuya, Tatsuru Okamura, Tsunekazu Hishima

Open Access Research Article

Change in weight and waist circumference and risk of colorectal cancer: results from the Melbourne Collaborative Cohort Study

Amalia Karahalios, Julie A. Simpson, Laura Baglietto, Robert J. MacInnis, Allison M. Hodge, Graham G. Giles, Dallas R. English

Open Access Research article

Combined hepatocellular carcinoma and cholangiocarcinoma (biphenotypic) tumors: clinical characteristics, imaging features of contrast-enhanced ultrasound and computed tomography

Rui Li, Dan Yang, Chun-Lin Tang, Ping Cai, Kuan-sheng Ma, Shi-Yi Ding, Xiao-Hang Zhang, De-Yu Guo, Xiao-Chu Yan

Open Access Research article

Distribution and features of hematological malignancies in Eastern Morocco: a retrospective multicenter study over 5 years

Mounia Elidrissi Errahhali, Manal Elidrissi Errahhali, Redouane Boulouiz, Meryem Ouarzane, Mohammed Bellaoui

Open Access Research article

Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448

Oluwaseun Adebayo Bamodu, Wen-Chien Huang, Wei-Hwa Lee, Alexander Wu, Liang Shun Wang, Michael Hsiao, Chi-Tai Yeh, Tsu-Yi Chao

Open Access Research article

Analytical performance of a bronchial genomic classifier

Zhanzhi Hu, Duncan Whitney, Jessica R. Anderson, Manqiu Cao, Christine Ho, Yoonha Choi, Jing Huang, Robert Frink, Kate Porta Smith, Robert Monroe, Giulia C. Kennedy, P. Sean Walsh

Open Access Research article

Treatment and outcome of 32 patients with distant metastases of Hürthle cell thyroid carcinoma: a single-institution experience

Nikola Besic, Andreja Schwarzbartl-Pevec, Barbara Vidergar-Kralj, Tea Crnic, Barbara Gazic, Maja Marolt Music

Open Access Research Article

Differences in predictions of ODE models of tumor growth: a cautionary example

Hope Murphy, Hana Jaafari, Hana M. Dobrovolny

Open Access Research article

Effect of vaccination age on cost-effectiveness of human papillomavirus vaccination against cervical cancer in China

Yi-Jun Liu, Qian Zhang, Shang-Ying Hu, Fang-Hui Zhao

Open Access Research article

Analysis of functional germline variants in APOBEC3 and driver genes on breast cancer risk in Moroccan study population

Chaymaa Marouf, Stella Göhler, Miguel Inacio Da Silva Filho, Omar Hajji, Kari Hemminki, Sellama Nadifi, Asta Försti

Open Access Research article

Myeloproliferative neoplasms (MPNs) have a significant impact on patients’ overall health and productivity: the MPN Landmark survey

Ruben Mesa, Carole B. Miller, Maureen Thyne, James Mangan, Sara Goldberger, Salman Fazal, Xiaomei Ma, Wendy Wilson, Dilan C. Paranagama, David G. Dubinski, John Boyle, John O. Mascarenhas

Open Access Research article

Vimentin and Ki67 expression in circulating tumour cells derived from castrate-resistant prostate cancer

C. R. Lindsay, S. Le Moulec, F. Billiot, Y. Loriot, M. Ngo-Camus, P. Vielh, K. Fizazi, C. Massard, F. Farace

Open Access Research article

Critical weight loss predicts poor prognosis in nasopharyngeal carcinoma

Qi Zeng, Lu-Jun Shen, Xiang Guo, Xin-Ming Guo, Chao-Nan Qian, Pei-Hong Wu

Open Access Research article

Clinical application of genomic profiling to find druggable targets for adolescent and young adult (AYA) cancer patients with metastasis

Soojin Cha, Jeongeun Lee, Jong-Yeon Shin, Ji-Yeon Kim, Sung Hoon Sim, Bhumsuk Keam, Tae Min Kim, Dong-Wan Kim, Dae Seog Heo, Se-Hoon Lee, Jong-Il Kim

Open Access Research article

More expression of BDNF associates with lung squamous cell carcinoma and is critical to the proliferation and invasion of lung cancer cells

Si-yang Zhang, Lin-ping Hui, Chun-yan Li, Jian Gao, Ze-shi Cui, Xue-shan Qiu

Open Access Research article

Binimetinib inhibits MEK and is effective against neuroblastoma tumor cells with low NF1 expression

Sarah E. Woodfield, Linna Zhang, Kathleen A. Scorsone, Yin Liu, Peter E. Zage

Open Access Research article

Cathepsin K induces platelet dysfunction and affects cell signaling in breast cancer - molecularly distinct behavior of cathepsin K in breast cancer

Sheila Siqueira Andrade, Iuri Estrada Gouvea, Mariana Cristina C. Silva, Eloísa Dognani Castro, Cláudia A. A. de Paula, Debora Okamoto, Lilian Oliveira, Giovani Bravin Peres, Tatiana Ottaiano, Gil Facina, Afonso Celso Pinto Nazário, Antonio Hugo J. F. M. Campos, Edgar Julian Paredes-Gamero, Maria Juliano, Ismael D. C. G. da Silva, Maria Luiza V. Oliva, Manoel J. B. C. Girão

Open Access Research article

Clinical significance of AGE-RAGE axis in colorectal cancer: associations with glyoxalase-I, adiponectin receptor expression and prognosis

Stratigoula Sakellariou, Paraskevi Fragkou, Georgia Levidou, Antonios N. Gargalionis, Christina Piperi, Georgia Dalagiorgou, Christos Adamopoulos, Angelica Saetta, George Agrogiannis, Irini Theohari, Stavros Sougioultzis, Panagiota Tsioli, Ioannis Karavokyros, Nikolaos Tsavaris, Ioannis D. Kostakis, Adamantia Zizi-Serbetzoglou, Gerasimos P. Vandoros, Efstratios Patsouris, Penelope Korkolopoulou

Open Access Research article

POU5F1/Oct-4 expression in breast cancer tissue is significantly associated with non-sentinel lymph node metastasis

Shouliang Cai, Shugang Geng, Feng Jin, Jisheng Liu, Chang Qu, Bo Chen

Open Access Research article

The anti-fibrotic agent pirfenidone synergizes with cisplatin in killing tumor cells and cancer-associated fibroblasts

Melanie Mediavilla-Varela, Kingsley Boateng, David Noyes, Scott J. Antonia

Open Access Erratum

Erratum to: IκBα mediates prostate cancer cell death induced by combinatorial targeting of the androgen receptor

Sarah L. Carter, Margaret M. Centenera, Wayne D. Tilley, Luke A. Selth, Lisa M. Butler

Open Access Research article

A pilot study to compare the detection of HPV-16 biomarkers in salivary oral rinses with tumour p16INK4a expression in head and neck squamous cell carcinoma patients

Ryan C. Chai, Yenkai Lim, Ian H. Frazer, Yunxia Wan, Christopher Perry, Lee Jones, Duncan Lambie, Chamindie Punyadeera

Open Access Research article

Stroke related to androgen deprivation therapy for prostate cancer: a meta-analysis and systematic review

Fanzheng Meng, Shimiao Zhu, Jinsheng Zhao, Larissa Vados, Lei Wang, Yusheng Zhao, Dan Zhao, Yuanjie Niu

Open Access Erratum

Erratum to: Population attributable risks of modifiable reproductive factors for breast and ovarian cancers in Korea

Boyoung Park, Sohee Park, Hai-Rim Shin, Aesun Shin, Yohwan Yeo, Ji-Yeob Choi, Kyu-Won Jung, Byoung-Gie Kim, Yong-Man Kim, Dong-Young Noh, Sei-Hyun Ahn, Jae Weon Kim, Sokbom Kang, Jae Hoon Kim, Tae Jin Kim, Daehee Kang, Keun-Young Yoo, Sue K. Park

Open Access Case report

Primary diffuse leptomeningeal gliomatosis as a rare cause of pain in cervical spine

Štefan Sivák, Ema Kantorová, Egon Kurča, Juraj Marcinek, Pavol Slávik, Jozef Michalik, Vladimír Nosáľ

Open Access Study protocol

A randomised phase II trial of Stereotactic Ablative Fractionated radiotherapy versus Radiosurgery for Oligometastatic Neoplasia to the lung (TROG 13.01 SAFRON II)

Shankar Siva, Tomas Kron, Mathias Bressel, Marion Haas, Tao Mai, Shalini Vinod, Giuseppe Sasso, Wenchang Wong, Hien Le, Thomas Eade, Nicholas Hardcastle, Brent Chesson, Daniel Pham, Morten Høyer, Rebecca Montgomery, David Ball

Open Access Research article

On Predicting lung cancer subtypes using ‘omic’ data from tumor and tumor-adjacent histologically-normal tissue

Arturo López Pineda, Henry Ato Ogoe, Jeya Balaji Balasubramanian, Claudia Rangel Escareño, Shyam Visweswaran, James Gordon Herman, Vanathi Gopalakrishnan

Open Access Research article

Neutrophil-to-lymphocyte ratio is a prognostic marker in bladder cancer patients after radical cystectomy

Takashi Kawahara, Kazuhiro Furuya, Manami Nakamura, Kentaro Sakamaki, Kimito Osaka, Hiroki Ito, Yusuke Ito, Koji Izumi, Shinji Ohtake, Yasuhide Miyoshi, Kazuhide Makiyama, Noboru Nakaigawa, Takeharu Yamanaka, Hiroshi Miyamoto, Masahiro Yao, Hiroji Uemura

Open Access Research article

Mitogen-activated protein kinase signaling causes malignant melanoma cells to differentially alter extracellular matrix biosynthesis to promote cell survival

Anna Afasizheva, Alexus Devine, Heather Tillman, King Leung Fung, Wilfred D. Vieira, Benjamin H. Blehm, Yorihisa Kotobuki, Ben Busby, Emily I. Chen, Kandice Tanner

Open Access Research article

Local iron homeostasis in the breast ductal carcinoma microenvironment

Oriana Marques, Graça Porto, Alexandra Rêma, Fátima Faria, Arnaud Cruz Paula, Maria Gomez-Lazaro, Paula Silva, Berta Martins da Silva, Carlos Lopes

Open Access Research article

Chronic ethanol feeding promotes azoxymethane and dextran sulfate sodium-induced colonic tumorigenesis potentially by enhancing mucosal inflammation

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Open Access Study protocol

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Open Access Research article

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Open Access Research article

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Open Access Research article

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miRNA profiling, detection of BRAF V600E mutation and RET-PTC1 translocation in patients from Novosibirsk oblast (Russia) with different types of thyroid tumors

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Open Access Study protocol

Testing the effects of narrative and play on physical activity among breast cancer survivors using mobile apps: study protocol for a randomized controlled trial

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Open Access Research article

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Urgent surgery after emergency presentation for colorectal cancer has no impact on overall and disease-free survival: a propensity score analysis

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Mutational status of synchronous and metachronous tumor samples in patients with metastatic non-small-cell lung cancer

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Open Access Research article

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Open Access Research article

Dynamic changes of alkaline phosphatase are strongly associated with PSA-decline and predict best clinical benefit earlier than PSA-changes under therapy with abiraterone acetate in bone metastatic castration resistant prostate cancer

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Open Access Research article

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Open Access Research article

Evaluation of the role of remission status in a heterogeneous limited disease small-cell lung cancer patient cohort treated with definitive chemoradiotherapy

Farkhad Manapov, Maximilian Niyazi, Sabine Gerum, Olarn Roengvoraphoj, Chukwuka Eze, Minglun Li, Guido Hildebrandt, Rainer Fietkau, Gunther Klautke, Claus Belka

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Man Niu, Dan Gao, Qiuyuan Wen, Pingpin Wei, Suming Pan, Cijun Shuai, Huiling Ma, Juanjuan Xiang, Zheng Li, Songqing Fan, Guiyuan Li, Shuping Peng

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Open Access Research article

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Pierre Kunz, Heiner Sähr, Burkhard Lehner, Christian Fischer, Elisabeth Seebach, Jörg Fellenberg

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Open Access Research article

Runs of homozygosity and inbreeding in thyroid cancer

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Open Access Research article

Nuclear expression of Lyn, a Src family kinase member, is associated with poor prognosis in renal cancer patients

Antonia K. Roseweir, Tahir Qayyum, Zhi Lim, Rachel Hammond, Alasdair I. MacDonald, Sioban Fraser, Grenville M. Oades, Michael Aitchison, Robert J. Jones, Joanne Edwards

Open Access Research article

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Open Access Case report

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Open Access Research article

Front-line intraperitoneal versus intravenous chemotherapy in stage III-IV epithelial ovarian, tubal, and peritoneal cancer with minimal residual disease: a competing risk analysis

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Open Access Research article

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Open Access Research article

Hair dye use, regular exercise, and the risk and prognosis of prostate cancer: multicenter case–control and case-only studies

Shu-Yu Tai, Hui-Min Hsieh, Shu-Pin Huang, Ming-Tsang Wu

Open Access Case report

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Honokiol inhibits sphere formation and xenograft growth of oral cancer side population cells accompanied with JAK/STAT signaling pathway suppression and apoptosis induction

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The milk-derived fusion peptide, ACFP, suppresses the growth of primary human ovarian cancer cells by regulating apoptotic gene expression and signaling pathways

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The prognostic value of lactate dehydrogenase levels in colorectal cancer: a meta-analysis

Guanghua Li, Zhao Wang, Jianbo Xu, Hui Wu, Shirong Cai, Yulong He

Open Access Research article

At least two well-spaced samples are needed to genotype a solid tumor

Kimberly Siegmund, Darryl Shibata

Open Access Research article

Antitumor effects of cecropin B-LHRH’ on drug-resistant ovarian and endometrial cancer cells

Xiaoyong Li, Bo Shen, Qi Chen, Xiaohui Zhang, Yiqing Ye, Fengmei Wang, Xinmei Zhang

Open Access Research article

Mmu-miR-125b overexpression suppresses NO production in activated macrophages by targeting eEF2K and CCNA2

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Open Access Research article

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Open Access Research article

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Cervical and breast cancer screening participation for women with chronic conditions in France: results from a national health survey

Panayotis Constantinou, Rosemary Dray-Spira, Gwenn Menvielle

Open Access Research article

CYP1A2 – a novel genetic marker for early aromatase inhibitor response in the treatment of breast cancer patients

Maria Simonsson, Srinivas Veerla, Andrea Markkula, Carsten Rose, Christian Ingvar, Helena Jernström

Open Access Research article

Nemo-like kinase as a negative regulator of nuclear receptor Nurr1 gene transcription in prostate cancer

Jian Wang, Zhi-Hong Yang, Hua Chen, Hua-Hui Li, Li-Yong Chen, Zhu Zhu, Ying Zou, Cong-Cong Ding, Jing Yang, Zhi-Wei He

Open Access Research article

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Angus G. K. McNair, F MacKichan, J. L. Donovan, S. T. Brookes, K. N. L. Avery, S. M. Griffin, T. Crosby, J. M. Blazeby

Open Access Research article

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Open Access Research article

Systematic review: brain metastases from colorectal cancer—Incidence and patient characteristics

Troels Dreier Christensen, Karen-Lise Garm Spindler, Jesper Andreas Palshof, Dorte Lisbet Nielsen

Open Access Research article

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Sanja Jurcevic, Karin Klinga-Levan, Björn Olsson, Katarina Ejeskär

Open Access Study protocol

Benchmarking trial between France and Australia comparing management of primary rectal cancer beyond TME and locally recurrent rectal cancer (PelviCare Trial): rationale and design

Quentin Denost, Florence Saillour, Lindy Masya, Helene Maillou Martinaud, Stephanie Guillon, Marion Kret, Eric Rullier, Bruno Quintard, Michael Solomon

Open Access Research article

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Open Access Study protocol

Advance care planning – a multi-centre cluster randomised clinical trial: the research protocol of the ACTION study

Judith A. C. Rietjens, Ida J. Korfage, Lesley Dunleavy, Nancy J. Preston, Lea J. Jabbarian, Caroline Arnfeldt Christensen, Maja de Brito, Francesco Bulli, Glenys Caswell, Branka Červ, Johannes van Delden, Luc Deliens, Giuseppe Gorini, Mogens Groenvold, Dirk Houttekier, Francesca Ingravallo, Marijke C. Kars, Urška Lunder, Guido Miccinesi, Alenka Mimić, Eugenio Paci, Sheila Payne, Suzanne Polinder, Kristian Pollock, Jane Seymour, Anja Simonič, Anna Thit Johnsen, Mariëtte N. Verkissen, Esther de Vries, Andrew Wilcock, Marieke Zwakman, Agnes van der Heide (Pl)

Open Access Research article

Randomized phase III trial of amrubicin/cisplatin versus etoposide/cisplatin as first-line treatment for extensive small-cell lung cancer

Yan Sun, Ying Cheng, Xuezhi Hao, Jie Wang, Chengping Hu, Baohui Han, Xiaoqing Liu, Li Zhang, Huiping Wan, Zhongjun Xia, Yunpeng Liu, Wei Li, Mei Hou, Helong Zhang, Qingyu Xiu, Yunzhong Zhu, Jifeng Feng, Shukui Qin, Xiaoyan Luo

Open Access Research article

A phase II study of Endostatin in combination with paclitaxel, carboplatin, and radiotherapy in patients with unresectable locally advanced non-small cell lung cancer

Xiao-Jiang Sun, Qing-Hua Deng, Xin-Min Yu, Yong-Lin Ji, Yuan-Da Zheng, Hao Jiang, Ya-Ping Xu, Sheng-Lin Ma

Open Access Research article

Minimal renal toxicity after Rituximab DHAP with a modified cisplatin application scheme in patients with relapsed or refractory diffuse large B-cell lymphoma

K. Lisenko, F. McClanahan, T. Schöning, M. A. Schwarzbich, M. Cremer, T. Dittrich, A. D. Ho, M. Witzens-Harig

Open Access Research article

Establishment and characterization of new cell lines of anaplastic pancreatic cancer, which is a rare malignancy: OCUP-A1 and OCUP-A2

Kotaro Miura, Kenjiro Kimura, Ryosuke Amano, Sadaaki Yamazoe, Go Ohira, Akihiro Murata, Kohei Nishio, Tsuyoshi Hasegawa, Masakazu Yashiro, Bunzo Nakata, Masaichi Ohira, Kosei Hirakawa

Open Access Research article

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Qiu-Mei Yao, Kai-Yan Liu, Robert Peter Gale, Bin Jiang, Yan-Rong Liu, Qian Jiang, Hao Jiang, Xiao-Hui Zhang, Mei-Jie Zhang, Shan-Shan Chen, Xiao-Jun Huang, Lan-Ping Xu, Guo-Rui Ruan

Open Access Research article

Treatment with anti-IL-6 receptor antibody prevented increase in serum hepcidin levels and improved anemia in mice inoculated with IL-6–producing lung carcinoma cells

Mariko Noguchi-Sasaki, Yusuke Sasaki, Yasushi Shimonaka, Kazushige Mori, Kaori Fujimoto-Ouchi

Open Access Research article

Comparative analysis of copy number variations in ulcerative colitis associated and sporadic colorectal neoplasia

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Open Access Erratum

Erratum to: Correlation between S-1 treatment outcome and expression of biomarkers for refractory thymic carcinoma

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Open Access Research article

Short-term culture of tumour slices reveals the heterogeneous sensitivity of human head and neck squamous cell carcinoma to targeted therapies

Jérôme Donnadieu, Emma Lachaier, Marine Peria, Zuzana Saidak, Stéphanie Dakpe, Jean-Fortune Ikoli, Bruno Chauffert, Cyril Page, Antoine Galmiche

Open Access Research article

Identification of stromal ColXα1 and tumor-infiltrating lymphocytes as putative predictive markers of neoadjuvant therapy in estrogen receptor-positive/HER2-positive breast cancer

Alexander S. Brodsky, Jinjun Xiong, Dongfang Yang, Christoph Schorl, Mary Anne Fenton, Theresa A. Graves, William M. Sikov, Murray B. Resnick, Yihong Wang

Open Access Erratum

Erratum to: Generation of an algorithm based on minimal gene sets to clinically subtype triple negative breast cancer patients

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Open Access Research article

Survivin protein expression is involved in the progression of non-small cell lung cancer in Asians: a meta-analysis

Liang Duan, Xuefei Hu, Yuxing Jin, Ruijun Liu, Qingjun You

Open Access Research article

Improvement of ablative margins by the intraoperative use of CEUS-CT/MR image fusion in hepatocellular carcinoma

Kai Li, Zhong-Zhen Su, Er-Jiao Xu, Jin-Xiu Ju, Xiao-Chun Meng, Rong-Qin Zheng

Open Access Study protocol

A phase Ia/Ib clinical trial of metronomic chemotherapy based on a mathematical model of oral vinorelbine in metastatic non-small cell lung cancer and malignant pleural mesothelioma: rationale and study protocol

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Open Access Research article

Selective activation of TNFR1 and NF-κB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells

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Open Access Research article

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E. Palmerini, R. L. Jones, E. Marchesi, A. Paioli, M. Cesari, A. Longhi, C. Meazza, L. Coccoli, F. Fagioli, S. Asaftei, G. Grignani, A. Tamburini, S. M. Pollack, P. Picci, S. Ferrari

Open Access Study protocol

The Lung Screen Uptake Trial (LSUT): protocol for a randomised controlled demonstration lung cancer screening pilot testing a targeted invitation strategy for high risk and ‘hard-to-reach’ patients

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Open Access Study protocol

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Open Access Research article

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Open Access Research article

Cancer incidence in urban Shanghai, 1973-2010: an updated trend and age-period-cohort effects

Ping-Ping Bao, Ying Zheng, Chun-Xiao Wu, Zhe-Zhou Huang, Yu-Tang Gao, Fan Jin, Yong-Bing Xiang, Wei-Jian Zhong, Wei Lu, Fan Wu

Open Access Research article

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Elisabet Ortiz-Tudela, Pasquale F. Innominato, Maria Angeles Rol, Francis Lévi, Juan Antonio Madrid

Open Access Research article

Basal metabolic state governs AIF-dependent growth support in pancreatic cancer cells

Andrew J. Scott, Amanda S. Wilkinson, John C. Wilkinson

Open Access Research article

Chemotherapy for intracranial ependymoma in adults

Dorothee Gramatzki, Patrick Roth, Jörg Felsberg, Silvia Hofer, Elisabeth J. Rushing, Bettina Hentschel, Manfred Westphal, Dietmar Krex, Matthias Simon, Oliver Schnell, Wolfgang Wick, Guido Reifenberger, Michael Weller

Open Access Research article

Lung cancer treatment and mortality for Aboriginal people in New South Wales, Australia: results from a population-based record linkage study and medical record audit

Alison Gibberd, Rajah Supramaniam, Anthony Dillon, Bruce K. Armstrong, Dianne L. O’Connell

Open Access Study protocol

Rationale and design of the German-Speaking Myeloma Multicenter Group (GMMG) trial ReLApsE: a randomized, open, multicenter phase III trial of lenalidomide/dexamethasone versus lenalidomide/dexamethasone plus subsequent autologous stem cell transplantation and lenalidomide maintenance in patients with relapsed multiple myeloma

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Open Access Study protocol

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Christine Maheu, Sophie Lebel, Christine Courbasson, Monique Lefebvre, Mina Singh, Lori J. Bernstein, Linda Muraca, Aronela Benea, Lynne Jolicoeur, Cheryl Harris, Agnihotram V. Ramanakumar, Sarah Ferguson, Souraya Sidani

Open Access Research article

A predictive tool particularly designed for elderly myeloma patients presenting with spinal cord compression

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Open Access Research article

The occurrence of non-melanoma malignant skin lesions and non-cutaneous squamous-cell carcinoma among metastatic melanoma patients: an observational cohort study in Denmark

Haojie Li, Lars Pedersen, Mette Nørgaard, Sinna P. Ulrichsen, Sandra K. Thygesen, Jeanenne J. Nelson

Open Access Research article

After low and high dose-rate interstitial brachytherapy followed by IMRT radiotherapy for intermediate and high risk prostate cancer

Satoshi Nakamura, Naoya Murakami, Koji Inaba, Akihisa Wakita, Kazuma Kobayashi, Kana Takahashi, Hiroyuki Okamoto, Rei Umezawa, Madoka Morota, Minako Sumi, Hiroshi Igaki, Yoshinori Ito, Jun Itami

Open Access Research article

Expression of the cereblon binding protein argonaute 2 plays an important role for multiple myeloma cell growth and survival

Qinqin Xu, Yue-xian Hou, Paul Langlais, Patrick Erickson, James Zhu, Chang-Xin Shi, Moulun Luo, Yuanxiao Zhu, Ye Xu, Lawrence J. Mandarino, Keith Stewart, Xiu-bao Chang

Open Access Study protocol

Focal vs extended ablation in localized prostate cancer with irreversible electroporation; a multi-center randomized controlled trial

Matthijs J. V. Scheltema, Willemien van den Bos, Daniel M. de Bruin, Hessel Wijkstra, M. Pilar Laguna, Theo M. de Reijke, Jean JMCH de la Rosette

Open Access Technical advance

A cell transportation solution that preserves live circulating tumor cells in patient blood samples

Steingrimur Stefansson, Daniel L. Adams, William B. Ershler, Huyen Le, David H. Ho

Open Access Research article

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Christian Rothermundt, Beatrice M. Seddon, Palma Dileo, Sandra J. Strauss, Joanne Coleman, Timothy W. Briggs, Sarah R. Haile, Jeremy S. Whelan

Open Access Research article

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Dechang Diao, Lei Wang, Jin Wan, Zhiqiang Chen, Junsheng Peng, Huanliang Liu, Xinlin Chen, Wei Wang, Liaonan Zou

Open Access Study protocol

Design of a multicentre randomized controlled trial to evaluate the effectiveness of a tailored clinical support intervention to enhance return to work for gastrointestinal cancer patients

AnneClaire G.N.M. Zaman, Kristien M.A.J. Tytgat, Jean H.G. Klinkenbijl, Monique H.W. Frings-Dresen, Angela G.E.M. de Boer

Open Access Research article

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Mamoru Morimoto, Yoichi Matsuo, Shuji Koide, Ken Tsuboi, Tomoya Shamoto, Takafumi Sato, Kenta Saito, Hiroki Takahashi, Hiromitsu Takeyama

Open Access Research article

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Open Access Research article

Evaluation of clinical parameters influencing the development of bone metastasis in breast cancer

Joachim Diessner, Manfred Wischnewsky, Tanja Stüber, Roland Stein, Mathias Krockenberger, Sebastian Häusler, Wolfgang Janni, Rolf Kreienberg, Maria Blettner, Lukas Schwentner, Achim Wöckel, Catharina Bartmann

Open Access Research article

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Lucia Kucerova, Lucia Demkova, Svetlana Skolekova, Roman Bohovic, Miroslava Matuskova

Open Access Research article

Heme oxygenase is not involved in the anti-proliferative effects of statins on pancreatic cancer cells

K. Vanova, S. Boukalova, H. Gbelcova, L. Muchova, J. Neuzil, R. Gurlich, T. Ruml, L. Vitek

Open Access Research article

Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet

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Open Access Research article

Smoking-related cancer in military veterans: retrospective cohort study of 57,000 veterans and 173,000 matched non-veterans

Beverly P. Bergman, Daniel F. Mackay, David Morrison, Jill P. Pell

Open Access Research article

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Laura Bonanno, Carlota Costa, Margarita Majem, Jose-Javier Sanchez, Ignacio Rodriguez, Ana Gimenez-Capitan, Miquel Angel Molina-Vila, Alain Vergnenegre, Bartomeu Massuti, Adolfo Favaretto, Massimo Rugge, Cinta Pallares, Miquel Taron, Rafael Rosell

Open Access Research article

Decreased expression of hyaluronan synthase 1 and 2 associates with poor prognosis in cutaneous melanoma

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Open Access Review

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Open Access Research article

MicroRNA-663a is downregulated in non-small cell lung cancer and inhibits proliferation and invasion by targeting JunD

Yi Zhang, Xiaoman Xu, Meng Zhang, Xin Wang, Xue Bai, Hui Li, Liang Kan, Yong Zhou, Huiyan Niu, Ping He

Open Access Research article

Epigenetically maintained SW13+ and SW13- subtypes have different oncogenic potential and convert with HDAC1 inhibition

McKale R. Davis, Juliane J. Daggett, Agnes S. Pascual, Jessica M. Lam, Kathryn J. Leyva, Kimbal E. Cooper, Elizabeth E. Hull

Open Access Research article

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Open Access Study protocol

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Open Access Study protocol

The role of the addition of ovarian suppression to tamoxifen in young women with hormone-sensitive breast cancer who remain premenopausal or regain menstruation after chemotherapy (ASTRRA): study protocol for a randomized controlled trial and progress

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Open Access Research article

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Open Access Case report

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Yaofeng Zhu, Shouzhen Chen, Songyu Chen, Jing Song, Fan Chen, Hu Guo, Zhenhua Shang, Yong Wang, Changkuo Zhou, Benkang Shi

Open Access Research article

Transarterial chemoembolization of hepatocellular carcinoma in a rat model: the effect of additional injection of survivin siRNA to the treatment protocol

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Open Access Research article

Progesterone receptor blockade in human breast cancer cells decreases cell cycle progression through G2/M by repressing G2/M genes

Susan E. Clare, Akash Gupta, MiRan Choi, Manish Ranjan, Oukseub Lee, Jun Wang, David Z. Ivancic, J. Julie Kim, Seema A. Khan

Open Access Research article

Primary tumor site is a useful predictor of cetuximab efficacy in the third-line or salvage treatment of KRAS wild-type (exon 2 non-mutant) metastatic colorectal cancer: a nationwide cohort study

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Open Access Research article

Activated thrombin-activatable fibrinolysis inhibitor (TAFIa) attenuates breast cancer cell metastatic behaviors through inhibition of plasminogen activation and extracellular proteolysis

Zainab A. Bazzi, Danielle Lanoue, Mouhanned El-Youssef, Rocco Romagnuolo, Janice Tubman, Dora Cavallo-Medved, Lisa A. Porter, Michael B. Boffa

Open Access Research article

Platelet to lymphocyte ratio as an independent prognostic indicator for prostate cancer patients receiving androgen deprivation therapy

Yanqing Wang, Fan Xu, Jiahua Pan, Yinjie Zhu, Xiaoguang Shao, Jianjun Sha, Zezhou Wang, Yong Cai, Qiang Liu, Baijun Dong, Wei Xue, Yiran Huang

Open Access Research article

Risk allelic load in Th2 and Th3 cytokines genes as biomarker of susceptibility to HPV-16 positive cervical cancer: a case control study

K. Torres-Poveda, A. I. Burguete-García, M. Bahena-Román, R. Méndez-Martínez, M. A. Zurita-Díaz, G. López-Estrada, K. Delgado-Romero, O. Peralta-Zaragoza, V. H. Bermúdez-Morales, D. Cantú, A. García-Carrancá, V. Madrid-Marina

Open Access Research article

The effect of soluble E-selectin on tumor progression and metastasis

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Open Access Research article

Corepressive function of nuclear receptor coactivator 2 in androgen receptor of prostate cancer cells treated with antiandrogen

Keisuke Takeda, Noboru Hara, Tsutomu Nishiyama, Masayuki Tasaki, Fumio Ishizaki, Yoshihiko Tomita

Open Access Research article

Importance of hereditary and selected environmental risk factors in the etiology of inflammatory breast cancer: a case-comparison study

Roxana Moslehi, Elizabeth Freedman, Nur Zeinomar, Carmela Veneroso, Paul H. Levine

Open Access Research article

Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor

Sarah Daakour, Leon Juvenal Hajingabo, Despoina Kerselidou, Aurelie Devresse, Richard Kettmann, Nicolas Simonis, Franck Dequiedt, Jean-Claude Twizere

Open Access Research article

Selective mode of action of plumbagin through BRCA1 deficient breast cancer stem cells

Veena Somasundaram, Sreelatha K Hemalatha, Krishnendu Pal, Sutapa Sinha, Asha S. Nair, Debabrata Mukhopadhyay, Priya Srinivas

Open Access Research article

SLCO1B1*5 polymorphism (rs4149056) is associated with chemotherapy-induced amenorrhea in premenopausal women with breast cancer: a prospective cohort study

Toralf Reimer, Sarah Kempert, Bernd Gerber, Hans-Jürgen Thiesen, Steffi Hartmann, Dirk Koczan

Open Access Research article

Potential efficacy of therapies targeting intrahepatic lesions after sorafenib treatment of patients with hepatocellular carcinoma

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Open Access Study protocol

ICECREAM: randomised phase II study of cetuximab alone or in combination with irinotecan in patients with metastatic colorectal cancer with either KRAS, NRAS, BRAF and PI3KCA wild type, or G13D mutated tumours

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Open Access Study protocol

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Open Access Research article

Cross-talk between the Tissue Factor/coagulation factor VIIa complex and the tyrosine kinase receptor EphA2 in cancer

Oskar Eriksson, Åsa Thulin, Anna Asplund, Geeta Hegde, Sanjay Navani, Agneta Siegbahn

Open Access Research article

Absence of an association of human polyomavirus and papillomavirus infection with lung cancer in China: a nested case–control study

Danny V. Colombara, Lisa E. Manhart, Joseph J. Carter, Stephen E. Hawes, Noel S. Weiss, James P. Hughes, You-Lin Qiao, Philip R. Taylor, Jennifer S. Smith, Denise A. Galloway

Open Access Research article

Economic evaluation of the breast cancer screening programme in the Basque Country: retrospective cost-effectiveness and budget impact analysis

Arantzazu Arrospide, Montserrat Rue, Nicolien T. van Ravesteyn, Merce Comas, Myriam Soto-Gordoa, Garbiñe Sarriugarte, Javier Mar

Open Access Research article

3D culture of Her2+ breast cancer cells promotes AKT to MAPK switching and a loss of therapeutic response

Sharath Gangadhara, Chris Smith, Peter Barrett-Lee, Stephen Hiscox

Open Access Research article

Ultrasound screening for cholangiocarcinoma could detect premalignant lesions and early-stage diseases with survival benefits: a population-based prospective study of 4,225 subjects in an endemic area

Prakongboon Sungkasubun, Surachate Siripongsakun, Kunlayanee Akkarachinorate, Sirachat Vidhyarkorn, Akeanong Worakitsitisatorn, Thaniya Sricharunrat, Sutida Singharuksa, Rawisak Chanwat, Chairat Bunchaliew, Sirima Charoenphattharaphesat, Ruechuta Molek, Maneenop Yimyaem, Gaidganok Sornsamdang, Kamonwan Soonklang, Kasiruck Wittayasak, Chirayu U. Auewarakul, Chulabhorn Mahidol

Open Access Research article

Clinical characteristics and prognosis of 272 postterm choriocarcinoma patients at Peking Union Medical College Hospital: a retrospective cohort study

Jie Li, Junjun Yang, Pengfei Liu, Tong Ren, Jun Zhao, Fengzhi Feng, Xirun Wan, Yang Xiang

Open Access Research article

Long-term outcomes in radically treated synchronous vs. metachronous oligometastatic non-small-cell lung cancer

Jochen Fleckenstein, Alev Petroff, Hans-Joachim Schäfers, Thomas Wehler, Jakob Schöpe, Christian Rübe

Open Access Research article

Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice

J. R. Hens, I. Sinha, F. Perodin, T. Cooper, R. Sinha, J. Plummer, C. E. Perrone, D. Orentreich

Open Access Research article

High-risk oral leukoplakia is associated with aberrant promoter methylation of multiple genes

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Open Access Research article

Prediction of non-muscle invasive bladder cancer outcomes assessed by innovative multimarker prognostic models

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Open Access Study protocol

HERMIONE: a randomized Phase 2 trial of MM-302 plus trastuzumab versus chemotherapy of physician’s choice plus trastuzumab in patients with previously treated, anthracycline-naïve, HER2-positive, locally advanced/metastatic breast cancer

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Open Access Research article

A functional microRNA library screen reveals miR-410 as a novel anti-apoptotic regulator of cholangiocarcinoma

Tiziana Palumbo, George A. Poultsides, Grigorios Kouraklis, Theodore Liakakos, Alexandra Drakaki, George Peros, Maria Hatziapostolou, Dimitrios Iliopoulos

Open Access Research article

Epidermal growth factor signals regulate dihydropyrimidine dehydrogenase expression in EGFR-mutated non-small-cell lung cancer

Tetsuro Tominaga, Tomoshi Tsuchiya, Koji Mochinaga, Junichi Arai, Naoya Yamasaki, Keitaro Matsumoto, Takuro Miyazaki, Toshiya Nagasaki, Atsushi Nanashima, Kazuhiro Tsukamoto, Takeshi Nagayasu

Open Access Research article

Time course decomposition of cell heterogeneity in TFEB signaling states reveals homeostatic mechanisms restricting the magnitude and duration of TFEB responses to mTOR activity modulation

Paula Andrea Marin Zapata, Carsten Jörn Beese, Anja Jünger, Giovanni Dalmasso, Nathan Ryan Brady, Anne Hamacher-Brady

Open Access Research article

Factors influencing diagnosis delay of advanced breast cancer in Moroccan women

A. Maghous, F. Rais, S. Ahid, N. Benhmidou, K. Bellahamou, H. Loughlimi, E. Marnouche, S. Elmajjaoui, H. Elkacemi, T. Kebdani, N. Benjaafar

Open Access Research article

Patients with hepatic breast cancer metastases demonstrate highly specific profiles of matrix metalloproteinases MMP-2 and MMP-9 after SIRT treatment as compared to other primary and secondary liver tumours

Olga Golubnitschaja, Kristina Yeghiazaryan, Helena Stricker, Daniela Trog, Hans H. Schild, Leonard Berliner

Open Access Research article

Comparative expression patterns and diagnostic efficacies of SR splicing factors and HNRNPA1 in gastric and colorectal cancer

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Open Access Research article

Osteopontin regulates proliferation, apoptosis, and migration of murine claudin-low mammary tumor cells

S. Saleh, D. E. Thompson, J. McConkey, P. Murray, R. A. Moorehead

Open Access Research article

Safety and feasibility of fasting in combination with platinum-based chemotherapy

Tanya B. Dorff, Susan Groshen, Agustin Garcia, Manali Shah, Denice Tsao-Wei, Huyen Pham, Chia-Wei Cheng, Sebastian Brandhorst, Pinchas Cohen, Min Wei, Valter Longo, David I. Quinn

Open Access Research article

Stimulation of triple negative breast cancer cell migration and metastases formation is prevented by chloroquine in a pre-irradiated mouse model

Gina Bouchard, Hélène Therriault, Sameh Geha, Yves Bérubé-Lauzière, Rachel Bujold, Caroline Saucier, Benoit Paquette

Open Access Research article

Can advanced new radiation therapy technologies improve outcome of high grade glioma (HGG) patients? analysis of 3D-conformal radiotherapy (3DCRT) versus volumetric-modulated arc therapy (VMAT) in patients treated with surgery, concomitant and adjuvant chemo-radiotherapy

Pierina Navarria, Federico Pessina, Luca Cozzi, Anna Maria Ascolese, Francesca Lobefalo, Antonella Stravato, Giuseppe D’Agostino, Ciro Franzese, Manuela Caroli, Lorenzo Bello, Marta Scorsetti

Open Access Research article

MYC and BCL2 overexpression is associated with a higher class of Memorial Sloan-Kettering Cancer Center prognostic model and poor clinical outcome in primary diffuse large B-cell lymphoma of the central nervous system

Sehui Kim, Soo Jeong Nam, Dohee Kwon, Hannah Kim, Eunyoung Lee, Tae Min Kim, Dae Seog Heo, Sung Hye Park, Chul Woo Kim, Yoon Kyung Jeon

Open Access Research article

Variation in use of targeted therapies for metastatic renal cell carcinoma: Results from a Dutch population-based registry

S. De Groot, S. Sleijfer, W. K. Redekop, E. Oosterwijk, J. B. A. G. Haanen, L. A. L. M. Kiemeney, C. A. Uyl-de Groot

Open Access Case report

Unusual association of non-anaplastic Wilms tumor and Cornelia de Lange syndrome: case report

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Open Access Research article

PTEN mRNA expression is less pronounced in left- than right-sided colon cancer: a retrospective observational study

Hidekazu Kuramochi, Ayako Nakamura, Go Nakajima, Yuka Kaneko, Tatsuo Araida, Masakazu Yamamoto, Kazuhiko Hayashi

Open Access Research article

Molecular analyses of unselected head and neck cancer cases demonstrates that human papillomavirus transcriptional activity is positively associated with survival and prognosis

Liam Masterson, David M. Winder, Siolian L. R. Ball, Katie Vaughan, Martin Lehmann, Lars-Uwe Scholtz, Jane C. Sterling, Holger H. Sudhoff, Peter K. C. Goon

Open Access Research article

A comparison of 12-gene colon cancer assay gene expression in African American and Caucasian patients with stage II colon cancer

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Open Access Erratum

Erratum to: A phase 1b study of Selumetinib in combination with Cisplatin and Gemcitabine in advanced or metastatic biliary tract cancer: the ABC-04 study

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Open Access Erratum

Erratum to: The effect of soluble E-selectin on tumor progression and metastasis

Shin-Ae Kang, Celine A. Blache, Sandra Bajana, Nafis Hasan, Mohamed Kamal, Yoshihiro Morita, Vineet Gupta, Bilegtsaikhan Tsolmon, K. Stephen Suh, David G. Gorenstein, Wajeeha Razaq, Hallgeir Rui, Takemi Tanaka

Open Access Research article

Tissue metabolic profiling of human gastric cancer assessed by 1H NMR

Huijuan Wang, Hailong Zhang, Pengchi Deng, Chunqi Liu, Dandan Li, Hui Jie, Hu Zhang, Zongguang Zhou, Ying-Lan Zhao

Open Access Debate

Debate: adjuvant whole brain radiotherapy or not? More data is the wiser choice

Gerald B. Fogarty, Angela Hong, Vinai Gondi, Bryan Burmeister, Kari Jacobsen, Serigne Lo, Elizabeth Paton, Brindha Shivalingam, John F. Thompson

Open Access Research article

Prognostic significance of p53 expression in patients with esophageal cancer: a meta-analysis

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Open Access Erratum

Erratum to: Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses vasculogenic mimicry and proliferation of highly aggressive pancreatic cancer PaTu8988 cells

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Open Access Research article

Long-term survival and BRCA status in male breast cancer: a retrospective single-center analysis

Piera Gargiulo, Matilde Pensabene, Monica Milano, Grazia Arpino, Mario Giuliano, Valeria Forestieri, Caterina Condello, Rossella Lauria, Sabino De Placido

Open Access Research article

Context dependent regulatory patterns of the androgen receptor and androgen receptor target genes

Jan Roger Olsen, Waqas Azeem, Margrete Reime Hellem, Kristo Marvyin, Yaping Hua, Yi Qu, Lisha Li, Biaoyang Lin, XI-Song Ke, Anne Margrete Øyan, Karl-Henning Kalland

Open Access Research article

Systematic drug screening reveals specific vulnerabilities and co-resistance patterns in endocrine-resistant breast cancer

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Open Access Research article

Suppression of cell migration is promoted by miR-944 through targeting of SIAH1 and PTP4A1 in breast cancer cells

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Open Access Research article

Transanal total mesorectal excision (taTME) for rectal cancer: a systematic review and meta-analysis of oncological and perioperative outcomes compared with laparoscopic total mesorectal excision

Bin Ma, Peng Gao, Yongxi Song, Cong Zhang, Changwang Zhang, Longyi Wang, Hongpeng Liu, Zhenning Wang

Open Access Research article

Survival rates of cancer patients with and without rheumatic disease: a retrospective cohort analysis

Jin Kyun Park, Ji Ae Yang, Eun Young Ahn, Sung Hae Chang, Yeong Wook Song, Jeffrey R. Curtis, Eun Bong Lee

Open Access Research article

Comparison of the miRNA profiles in HPV-positive and HPV-negative tonsillar tumors and a model system of human keratinocyte clones

Zuzana Vojtechova, Ivan Sabol, Martina Salakova, Jana Smahelova, Jiri Zavadil, Lubomir Turek, Marek Grega, Jan Klozar, Bohumir Prochazka, Ruth Tachezy

Open Access Research article

Metalloproteases meprin-ɑ (MEP1A) is a prognostic biomarker and promotes proliferation and invasion of colorectal cancer

Xiao Wang, Jian Chen, Jingtao Wang, Fudong Yu, Senlin Zhao, Yu Zhang, Huamei Tang, Zhihai Peng

Open Access Case report

Cetuximab-induced aseptic meningitis: case report and review of a rare adverse event

Christophe Maritaz, Carole Metz, Nabil Baba-Hamed, Méryam Jardin-Szucs, Gaël Deplanque

Open Access Research article

Bone alkaline phosphatase as a surrogate marker of bone metastasis in gastric cancer patients

Sun Min Lim, Youn Nam Kim, Ki Hyun Park, Beodeul Kang, Hong Jae Chon, Chan Kim, Joo Hoon Kim, Sun Young Rha

Open Access Debate

TAS-102, the first “cardio-gentle” fluoropyrimidine in the colorectal cancer landscape?

Fausto Petrelli, Sandro Barni, Paola Bertocchi, Alberto Zaniboni

Open Access Study protocol

Lifestyle in Multiple Myeloma - a longitudinal cohort study protocol

M. Heinrich, A. Fisher, B. Paton, O. McCourt, R. J. Beeken, A. Hackshaw, J. Wardle, K. Yong

Open Access Research article

CD80 down-regulation is associated to aberrant DNA methylation in non-inflammatory colon carcinogenesis

Marco Scarpa, Melania Scarpa, Ignazio Castagliuolo, Francesca Erroi, Silvia Basato, Paola Brun, Imerio Angriman, Carlo Castoro

Open Access Research article

The use of a multiple imputation method to investigate the trends in Histologic types of lung cancer in Songkhla province, Thailand, 1989–2013

Hutcha Sriplung, Seesai Yeesoonsang, Edward McNeil, Surichai Bilheem

Open Access Case report

A case of lymphangioleiomyomatosis associated with endometrial cancer and severe systemic lupus erythematosus

Kensuke Suzuki, Kazunori Nagasaka, Katsutoshi Oda, Hiroyuki Abe, Daichi Maeda, Yoko Matsumoto, Takahide Arimoto, Kei Kawana, Masashi Fukayama, Yutaka Osuga, Tomoyuki Fujii

Open Access Case report

Expansive hematoma in delayed cerebral radiation necrosis in patients treated with T-DM1: a report of two cases

Koichi Mitsuya, Junichiro Watanabe, Yoko Nakasu, Nakamasa Hayashi, Hideyuki Harada, Ichiro Ito

Open Access Research article

Use and misuse of common terminology criteria for adverse events in cancer clinical trials

Sheng Zhang, Fei Liang, Ian Tannock

Open Access Research article

GSK-3 directly regulates phospho-4EBP1 in renal cell carcinoma cell-line: an intrinsic subcellular mechanism for resistance to mTORC1 inhibition

Hiromi Ito, Osamu Ichiyanagi, Sei Naito, Vladimir N. Bilim, Yoshihiko Tomita, Tomoyuki Kato, Akira Nagaoka, Norihiko Tsuchiya

Open Access Research article

Occupational prestige, social mobility and the association with lung cancer in men

Thomas Behrens, Isabelle Groß, Jack Siemiatycki, David I. Conway, Ann Olsson, Isabelle Stücker, Florence Guida, Karl-Heinz Jöckel, Hermann Pohlabeln, Wolfgang Ahrens, Irene Brüske, Heinz-Erich Wichmann, Per Gustavsson, Dario Consonni, Franco Merletti, Lorenzo Richiardi, Lorenzo Simonato, Cristina Fortes, Marie-Elise Parent, John McLaughlin, Paul Demers, Maria Teresa Landi, Neil Caporaso, David Zaridze, Neonila Szeszenia-Dabrowska, Peter Rudnai, Jolanta Lissowska, Eleonora Fabianova, Adonina Tardón, John K. Field, Rodica Stanescu Dumitru, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Hans Kromhout, Roel Vermeulen, Paolo Boffetta, Kurt Straif, Joachim Schüz, Jan Hovanec, Benjamin Kendzia, Beate Pesch, Thomas Brüning

Open Access Research article

Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer

Jun Kasuga, Takashi Kawahara, Daiji Takamoto, Sachi Fukui, Takashi Tokita, Tomoyuki Tadenuma, Masaki Narahara, Syusei Fusayasu, Hideyuki Terao, Koji Izumi, Hiroki Ito, Yusuke Hattori, Jun-ichi Teranishi, Takeshi Sasaki, Kazuhide Makiyama, Yasuhide Miyoshi, Masahiro Yao, Yasushi Yumura, Hiroshi Miyamoto, Hiroji Uemura

Open Access Technical advance

Technical validation of an RT-qPCR in vitro diagnostic test system for the determination of breast cancer molecular subtypes by quantification of ERBB2, ESR1, PGR and MKI67 mRNA levels from formalin-fixed paraffin-embedded breast tumor specimens

Mark Laible, Kornelia Schlombs, Katharina Kaiser, Elke Veltrup, Stefanie Herlein, Sotiris Lakis, Robert Stöhr, Sebastian Eidt, Arndt Hartmann, Ralph M. Wirtz, Ugur Sahin

Open Access Research article

Epigenetic silencing of serine protease HTRA1 drives polyploidy

Nina Schmidt, Inga Irle, Kamilla Ripkens, Vanda Lux, Jasmin Nelles, Christian Johannes, Lee Parry, Kirsty Greenow, Sarah Amir, Mara Campioni, Alfonso Baldi, Chio Oka, Masashi Kawaichi, Alan R. Clarke, Michael Ehrmann

Open Access Research article

Prognostic and clinical impact of PIK3CA mutation in gastric cancer: pyrosequencing technology and literature review

Kazuto Harada, Yoshifumi Baba, Hironobu Shigaki, Takatsugu Ishimoto, Keisuke Miyake, Keisuke Kosumi, Ryuma Tokunaga, Daisuke Izumi, Mayuko Ohuchi, Kenichi Nakamura, Yuki Kiyozumi, Junji Kurashige, Masaaki Iwatsuki, Yuji Miyamoto, Yasuo Sakamoto, Naoya Yoshida, Masayuki Watanabe, Hideo Baba

Open Access Research article

Detection of circulating tumor cells using manually performed immunocytochemistry (MICC) does not correlate with outcome in patients with early breast cancer – Results of the German SUCCESS-A- trial

Julia Jueckstock, Brigitte Rack, Thomas W. P. Friedl, Christoph Scholz, Julia Steidl, Elisabeth Trapp, Hans Tesch, Helmut Forstbauer, Ralf Lorenz, Mahdi Rezai, Lothar Häberle, Marianna Alunni-Fabbroni, Andreas Schneeweiss, Matthias W. Beckmann, Werner Lichtenegger, Peter A. Fasching, Klaus Pantel, Wolfgang Janni

Open Access Research article

Pre-diagnostic body mass index and weight change in relation to colorectal cancer survival among incident cases from a population-based cohort study

Ida Laake, Inger K. Larsen, Randi Selmer, Inger Thune, Marit B. Veierød

Open Access Research article

Chemotherapy versus radiotherapy for FIGO stages IB1 and IIA1 cervical carcinoma patients with postoperative isolated deep stromal invasion: a retrospective study

Lei Li, XiaoYan Song, RuoNan Liu, Nan Li, Ye Zhang, Yan Cheng, HongTu Chao, LiYing Wang

Open Access Research article

Eribulin-induced liver dysfunction as a prognostic indicator of survival of metastatic breast cancer patients: a retrospective study

Takayuki Kobayashi, Jyunichi Tomomatsu, Ippei Fukada, Tomoko Shibayama, Natsuki Teruya, Yoshinori Ito, Takuji Iwase, Shinji Ohno, Shunji Takahashi

Open Access Research article

EGFR gene amplification is relatively common and associates with outcome in intestinal adenocarcinoma of the stomach, gastro-oesophageal junction and distal oesophagus

Eva-Maria Birkman, Annika Ålgars, Minnamaija Lintunen, Raija Ristamäki, Jari Sundström, Olli Carpén

Open Access Research article

Metabolic syndrome is associated with advanced prostate cancer in patients treated with radical retropubic prostatectomy: results from a multicentre prospective study

Cosimo De Nunzio, Giuseppe Simone, Aldo Brassetti, Riccardo Mastroianni, Devis Collura, Giovanni Muto, Michele Gallucci, Andrea Tubaro

Open Access Study protocol

Psychosocial impact of prognostic genetic testing in the care of uveal melanoma patients: protocol of a controlled prospective clinical observational study

Yesim Erim, Jennifer Scheel, Anja Breidenstein, Claudia HD Metz, Dietmar Lohmann, Hans-Christoph Friederich, Sefik Tagay

Open Access Research article

Interleukin-22 is elevated in lavage from patients with lung cancer and other pulmonary diseases

Amanda Tufman, Rudolf Maria Huber, Stefanie Völk, Frederic Aigner, Martin Edelmann, Fernando Gamarra, Rosemarie Kiefl, Kathrin Kahnert, Fei Tian, Anne-Laure Boulesteix, Stefan Endres, Sebastian Kobold

Open Access Research article

Clinicopathological and prognostic significance of GPX2 protein expression in esophageal squamous cell carcinoma

Zhijin Lei, Dongping Tian, Chong Zhang, Shukun Zhao, Min Su

Open Access Research article

Fluorescent imaging of superficial head and neck squamous cell carcinoma using a γ-glutamyltranspeptidase-activated targeting agent: a pilot study

Takeshi Mizushima, Shunsuke Ohnishi, Yuichi Shimizu, Yutaka Hatanaka, Kanako C. Hatanaka, Hidetaka Hosono, Yoshimasa Kubota, Mitsuteru Natsuizaka, Mako Kamiya, Shouko Ono, Akihiro Homma, Mototsugu Kato, Naoya Sakamoto, Yasuteru Urano

Open Access Research article

Survival, safety, and prognostic factors for outcome with Regorafenib in patients with metastatic colorectal cancer refractory to standard therapies: results from a multicenter study (REBECCA) nested within a compassionate use program

Antoine Adenis, Christelle de la Fouchardiere, Bernard Paule, Pascal Burtin, David Tougeron, Jennifer Wallet, Louis-Marie Dourthe, Pierre-Luc Etienne, Laurent Mineur, Stéphanie Clisant, Jean-Marc Phelip, Andrew Kramar, Thierry Andre

Open Access Research article

Mammographic density and structural features can individually and jointly contribute to breast cancer risk assessment in mammography screening: a case–control study

Rikke Rass Winkel, My von Euler-Chelpin, Mads Nielsen, Kersten Petersen, Martin Lillholm, Michael Bachmann Nielsen, Elsebeth Lynge, Wei Yao Uldall, Ilse Vejborg

Open Access Research article

Tumor-suppressive effects of atelocollagen-conjugated hsa-miR-520d-5p on un-differentiated cancer cells in a mouse xenograft model

Yoshitaka Ishihara, Satoshi Tsuno, Satoshi Kuwamoto, Taro Yamashita, Yusuke Endo, Keigo Miura, Yugo Miura, Takemasa Sato, Junichi Hasegawa, Norimasa Miura

Open Access Study protocol

ColoNav: patient navigation for colorectal cancer screening in deprived areas – Study protocol

C. Allary, A. Bourmaud, F. Tinquaut, M. Oriol, J. Kalecinski, V. Dutertre, N. Lechopier, M. Pommier, Y. Benoist, S. Rousseau, V. Regnier, V. Buthion, F. Chauvin

Open Access Research article

Predictive factors for a long-term response duration in non-squamous cell lung cancer patients treated with pemetrexed

Sojung Park, Hyun Jung Kim, Chang–Min Choi, Dae Ho Lee, Sang–We Kim, Jung–Shin Lee, Woo Sung Kim, Se Hoon Choi, Jin Kyung Rho, Jae Cheol Lee

Open Access Research article

Macrophage phenotypic subtypes diametrically regulate epithelial-mesenchymal plasticity in breast cancer cells

Min Yang, Bo Ma, Hanshuang Shao, Amanda M. Clark, Alan Wells

Open Access Research article

A phase I trial of the trifunctional anti Her2 × anti CD3 antibody ertumaxomab in patients with advanced solid tumors

N. Haense, A. Atmaca, C. Pauligk, K. Steinmetz, F. Marmé, G. M. Haag, M. Rieger, O. G. Ottmann, P. Ruf, H. Lindhofer, S.-E. Al-Batran

Open Access Research article

Increased toll-like receptors and p53 levels regulate apoptosis and angiogenesis in non-muscle invasive bladder cancer: mechanism of action of P-MAPA biological response modifier

Patrick Vianna Garcia, Fábio Rodrigues Ferreira Seiva, Amanda Pocol Carniato, Wilson de Mello Júnior, Nelson Duran, Alda Maria Macedo, Alexandre Gabarra de Oliveira, Rok Romih, Iseu da Silva Nunes, Odilon da Silva Nunes, Wagner José Fávaro

Open Access Research article

Delphinidin-3-glucoside suppresses breast carcinogenesis by inactivating the Akt/HOTAIR signaling pathway

Xiaohong Yang, En Luo, Xin Liu, Bin Han, Xiaoping Yu, Xiaoli Peng

Open Access Research article

Optimal staging system for predicting the prognosis of patients with hepatocellular carcinoma in China: a retrospective study

Lihui Su, Tao Zhou, Zongli Zhang, Xiuguo Zhang, Xuting Zhi, Caixia Li, Qingliang Wang, Chongqi Jia, Wenna Shi, Yanqiu Yue, Yanjing Gao, Baoquan Cheng

Open Access Research article

The eicosanoids leukotriene D4 and prostaglandin E2 promote the tumorigenicity of colon cancer-initiating cells in a xenograft mouse model

Kishan Bellamkonda, Naveen Kumar Chandrashekar, Janina Osman, Benson Chellakkan Selvanesan, Sayeh Savari, Anita Sjölander

Open Access Research article

Increasing incidence of thyroid cancer in the Nordic countries with main focus on Swedish data

Michael Carlberg, Lena Hedendahl, Mikko Ahonen, Tarmo Koppel, Lennart Hardell

Open Access Research article

The impact of disease-related symptoms and palliative care concerns on health-related quality of life in multiple myeloma: a multi-centre study

Christina Ramsenthaler, Thomas R. Osborne, Wei Gao, Richard J. Siegert, Polly M. Edmonds, Stephen A. Schey, Irene J. Higginson

Open Access Research article

Serum HER2 extra-cellular domain, S100ß and CA 15-3 levels are independent prognostic factors in metastatic breast cancer patients

Amélie Darlix, Pierre-Jean Lamy, Evelyne Lopez-Crapez, Antoine Laurent Braccini, Nelly Firmin, Gilles Romieu, Simon Thezenas, William Jacot

Open Access Case report

Efficacy of sorafenib in BRAF-mutated non-small-cell lung cancer (NSCLC) and no response in synchronous BRAF wild type-hepatocellular carcinoma: a case report

Andrea Casadei Gardini, Elisa Chiadini, Luca Faloppi, Giorgia Marisi, Angelo Delmonte, Mario Scartozzi, Cristian Loretelli, Alessandro Lucchesi, Devil Oboldi, Alessandra Dubini, Giovanni Luca Frassineti, Paola Ulivi

Open Access Research article

Factors associated with late recurrence after completion of 5-year adjuvant tamoxifen in estrogen receptor positive breast cancer

Eun-Shin Lee, Wonshik Han, Min Kyoon Kim, Jongjin Kim, Tae-kyung Yoo, Moo Hyun Lee, Kyung Hun Lee, Tae Yong Kim, Hyeong-Gon Moon, Seock-Ah Im, Dong-Young Noh, Eun Sook Lee

Open Access Research article

Coalition of Oct4A and β1 integrins in facilitating metastasis in ovarian cancer

Chantel Samardzija, Rodney B. Luwor, Michael A. Quinn, George Kannourakis, Jock K. Findlay, Nuzhat Ahmed

Open Access Research article

Prognostic impact of circulating tumor cell apoptosis and clusters in serial blood samples from patients with metastatic breast cancer in a prospective observational cohort

Sara Jansson, Pär-Ola Bendahl, Anna-Maria Larsson, Kristina E. Aaltonen, Lisa Rydén

Open Access Research article

Prognostic implications of PD-L1 expression in patients with soft tissue sarcoma

Chan Kim, Eun Kyung Kim, Hun Jung, Hong Jae Chon, Jung Woo Han, Kyoo-Ho Shin, Hyuk Hu, Kyung Sik Kim, Young Deuk Choi, Sunghoon Kim, Young Han Lee, Jin-Suck Suh, Joong Bae Ahn, Hyun Cheol Chung, Sung Hoon Noh, Sun Young Rha, Soo Hee Kim, Hyo Song Kim

Open Access Study protocol

Colorectal cancer health services research study protocol: the CCR-CARESS observational prospective cohort project

José M. Quintana, Nerea Gonzalez, Ane Anton-Ladislao, Maximino Redondo, Marisa Bare, Nerea Fernandez de Larrea, Eduardo Briones, Antonio Escobar, Cristina Sarasqueta, Susana Garcia-Gutierrez, Urko Aguirre, Jose María Quintana, Marisa Baré, Maximino Redondo, Eduardo Briones, Nerea Fernández de Larrea, Cristina Sarasqueta, Antonio Escobar, Francisco Rivas, Maria M. Morales-Suárez-, Juan Antonio Blasco, Isabel del Cura, Inmaculada Arostegui, Amaia Bilbao, Nerea González, Susana García-Gutiérrez, Iratxe Lafuente, Urko Aguirre, Miren Orive, Josune Martin, Ane Antón-Ladislao, Núria Torà, Marina Pont, María Purificación Martínez del Prado, Alberto Loizate, Ignacio Zabalza, José Errasti, Antonio Z Gimeno, Santiago Lázaro, Mercè Comas, Jose María Enríquez, Carlos Placer, Amaia Perales, Iñaki Urkidi, Jose María Erro, Enrique Cormenzana, Adelaida Lacasta, Pep Piera Pibernat, Elena Campano, Ana Isabel Sotelo, Segundo Gómez-Abril, F. Medina-Cano, Julia Alcaide, Arturo Del Rey-Moreno, Manuel Jesús Alcántara, Rafael Campo, Alex Casalots, Carles Pericay, Maria José Gil, Miquel Pera, Pablo Collera, Josep Alfons Espinàs, Mercedes Martínez, Mireia Espallargues, Caridad Almazán, Paula Dujovne Lindenbaum, José María Fernández-Cebrián, Rocío Anula Fernández, Julio Ángel Mayol, Ramón Cantero, Héctor Guadalajara, María Heras, Damián García, Mariel Morey, Javier Mar

Open Access Research article

Changes of Socio-demographic data of clients seeking genetic counseling for hereditary breast and ovarian cancer due to the “Angelina Jolie Effect”

Christine Staudigl, Georg Pfeiler, Katharina Hrauda, Romana Renz, Andreas Berger, Renate Lichtenschopf, Christian F. Singer, Muy-Kheng M. Tea

Open Access Research article

Comparison of weekly administration of cisplatin versus three courses of cisplatin 100 mg/m2 for definitive radiochemotherapy of locally advanced head-and-neck cancers

Dirk Rades, Daniel Seidl, Stefan Janssen, Amira Bajrovic, Katarina Karner, Primoz Strojan, Steven E Schild

Open Access Research article

Total antioxidant intake and prostate cancer in the Cancer of the Prostate in Sweden (CAPS) study. A case control study

Kjell M. Russnes, Elisabeth Möller, Kathryn M. Wilson, Monica Carlsen, Rune Blomhoff, Sigbjørn Smeland, Hans-Olov Adami, Henrik Grönberg, Lorelei A. Mucci, Katarina Bälter

Open Access Research article

The triptolide derivative MRx102 inhibits Wnt pathway activation and has potent anti-tumor effects in lung cancer

Theresa A. Reno, Sun-Wing Tong, Jun Wu, John M. Fidler, Rebecca Nelson, Jae Y. Kim, Dan J. Raz

Open Access Research article

Osteopontin splice variants are differential predictors of breast cancer treatment responses

Krzysztof Zduniak, Anil Agrawal, Siddarth Agrawal, Md Monir Hossain, Piotr Ziolkowski, Georg F. Weber

Open Access Research article

Clinical relevance of peroxisome proliferator-activated receptor-gamma expression in myxoid liposarcoma

Akihiko Takeuchi, Norio Yamamoto, Toshiharu Shirai, Katsuhiro Hayashi, Shinji Miwa, Seiichi Munesue, Yasuhiko Yamamoto, Hiroyuki Tsuchiya

Open Access Research article

Erlotinib plus gemcitabine versus gemcitabine for pancreatic cancer: real-world analysis of Korean national database

Sangjin Shin, Chan Mi Park, Hanbyeol Kwon, Kyung-Hun Lee

Open Access Research article

Spinal disease in myeloma: cohort analysis at a specialist spinal surgery centre indicates benefit of early surgical augmentation or bracing

Karan Malhotra, Joseph S. Butler, Hai Ming Yu, Susanne Selvadurai, Shirley D’Sa, Neil Rabin, Charalampia Kyriakou, Kwee Yong, Sean Molloy

Open Access Study protocol

Implementation of immunochemical faecal occult blood test in general practice: a study protocol using a cluster-randomised stepped-wedge design

Jakob Søgaard Juul, Flemming Bro, Nete Hornung, Berit Sanne Andersen, Søren Laurberg, Frede Olesen, Peter Vedsted

Open Access Research article

Population attributable fraction of Esophageal squamous cell carcinoma due to smoking and alcohol in Uganda

Samson Okello, Cristina Churchill, Rogers Owori, Benson Nasasira, Christine Tumuhimbise, Charles Lagoro Abonga, David Mutiibwa, David C. Christiani, Kathleen E. Corey

Open Access Case report

Alveolar Rhabdomyosarcoma of the foot metastasizing to the Iris: report of a rare case

Ido Didi Fabian, G. Darius Hildebrand, Shaun Wilson, Tina Foord, Mandeep S. Sagoo

Open Access Research article

Prognostic significance of annexin A2 and annexin A4 expression in patients with cervical cancer

Chel Hun Choi, Joon-Yong Chung, Eun Joo Chung, John D. Sears, Jeong-Won Lee, Duk-Soo Bae, Stephen M. Hewitt

Open Access Research article

Fast-track surgery improves postoperative clinical recovery and cellular and humoral immunity after esophagectomy for esophageal cancer

Lantao Chen, Lixin Sun, Yaoguo Lang, Jun Wu, Lei Yao, Jinfeng Ning, Jinfeng Zhang, Shidong Xu

Open Access Research article

Retrospective and comparative analysis of 99mTc-Sestamibi breast specific gamma imaging versus mammography, ultrasound, and magnetic resonance imaging for the detection of breast cancer in Chinese women

Xiuyan Yu, Guoming Hu, Zhigang Zhang, Fuming Qiu, Xuan Shao, Xiaochen Wang, Hongwei Zhan, Yiding Chen, Yongchuan Deng, Jian Huang

Open Access Research article

Clinical outcomes and prognostic factors of cyberknife stereotactic body radiation therapy for unresectable hepatocellular carcinoma

Jenny Que, Hsing-Tao Kuo, Li-Ching Lin, Kuei-Li Lin, Chia-Hui Lin, Yu-Wei Lin, Ching-Chieh Yang

Open Access Research article

Silibinin induces mitochondrial NOX4-mediated endoplasmic reticulum stress response and its subsequent apoptosis

Sang-Hun Kim, Kwang-Youn Kim, Sun-Nyoung Yu, Young-Kyo Seo, Sung-Sik Chun, Hak-Sun Yu, Soon-Cheol Ahn

Open Access Debate

Insulin-like growth factor-1 signaling in renal cell carcinoma

Adam F. Tracz, Cezary Szczylik, Camillo Porta, Anna M. Czarnecka

Open Access Research article

Highly sensitive detection of the PIK3CA H1047R mutation in colorectal cancer using a novel PCR-RFLP method

Wan-Ming Li, Ting-Ting Hu, Lin-Lin Zhou, Yi-Ming Feng, Yun-Yi Wang, Jin Fang

Open Access Research article

Combination of a third generation bisphosphonate and replication-competent adenoviruses augments the cytotoxicity on mesothelioma

Yuanyuan Jiang, Boya Zhong, Kiyoko Kawamura, Takao Morinaga, Masato Shingyoji, Ikuo Sekine, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa

Open Access Research article

Health professionals and the early detection of head and neck cancers: a population-based study in a high incidence area

Karine Ligier, Olivier Dejardin, Ludivine Launay, Emmanuel Benoit, Emmanuel Babin, Simona Bara, Bénédicte Lapôtre-Ledoux, Guy Launoy, Anne-Valérie Guizard

Open Access Research article

COX-2 rs689466, rs5275, and rs20417 polymorphisms and risk of head and neck squamous cell carcinoma: a meta-analysis of adjusted and unadjusted data

Wei-Dong Leng, Xiu-Jie Wen, Joey S. W. Kwong, Wei Huang, Jian-Gang Chen, Xian-Tao Zeng

Open Access Research article

The impact of breast cancer biological subtyping on tumor size assessment by ultrasound and mammography - a retrospective multicenter cohort study of 6543 primary breast cancer patients

Roland Gregor Stein, Daniel Wollschläger, Rolf Kreienberg, Wolfgang Janni, Manfred Wischnewsky, Joachim Diessner, Tanja Stüber, Catharina Bartmann, Mathias Krockenberger, Jörg Wischhusen, Achim Wöckel, Maria Blettner, Lukas Schwentner

Open Access Research article

Combination of VP3 and CD147-knockdown enhance apoptosis and tumor growth delay index in colorectal tumor allograft

Ruzila Ismail, Zeenathul Nazariah Allaudin, Rasedee Abdullah, Mohd-Azmi Mohd Lila, Nik-Mohd-Afizan Nik Abd. Rahman, Sheikh-Omar Abdul Rahman

Open Access Research article

Antitumour responses induced by a cell-based Reovirus vaccine in murine lung and melanoma models

Ciorsdan A. Campion, Declan Soden, Patrick F. Forde

Open Access Research article

Phase I/II dose-finding study of nanoparticle albumin-bound paclitaxel (nab®-Paclitaxel) plus Cisplatin as Treatment for Metastatic Nasopharyngeal Carcinoma

Yan Huang, Wenhua Liang, Yunpeng Yang, Liping Zhao, Hongyun Zhao, Xuan Wu, Yuanyuan Zhao, Yang Zhang, Li Zhang

Open Access Research article

A pilot study to determine the timing and effect of bevacizumab on vascular normalization of metastatic brain tumors in breast cancer

Bang-Bin Chen, Yen-Shen Lu, Ching-Hung Lin, Wei-Wu Chen, Pei-Fang Wu, Chao-Yu Hsu, Chih-Wei Yu, Shwu-Yuan Wei, Ann-Lii Cheng, Tiffany Ting-Fang Shih

Open Access Research article

Chemotherapy induced neutropenia at 1-month mark is a predictor of overall survival in patients receiving TAS-102 for refractory metastatic colorectal cancer: a cohort study

Pashtoon M. Kasi, Daisuke Kotani, Michael Cecchini, Kohei Shitara, Atsushi Ohtsu, Ramesh K. Ramanathan, Howard S. Hochster, Axel Grothey, Takayuki Yoshino

Open Access Research article

Neoadjuvant irinotecan, cisplatin, and concurrent radiation therapy with celecoxib for patients with locally advanced esophageal cancer

James M. Cleary, Harvey J. Mamon, Jackie Szymonifka, Raphael Bueno, Noah Choi, Dean M. Donahue, Panos M. Fidias, Henning A. Gaissert, Michael T. Jaklitsch, Matthew H. Kulke, Thomas P. Lynch, Steven J. Mentzer, Jeffrey A. Meyerhardt, Richard S. Swanson, John Wain, Charles S. Fuchs, Peter C. Enzinger

Open Access Research article

Differential cytotoxicity induced by the Titanium(IV)Salan complex Tc52 in G2-phase independent of DNA damage

Theresa Pesch, Harald Schuhwerk, Philippe Wyrsch, Timo Immel, Wilhelm Dirks, Alexander Bürkle, Thomas Huhn, Sascha Beneke

Open Access Research article

EHD1 confers resistance to cisplatin in non-small cell lung cancer by regulating intracellular cisplatin concentrations

Jing Gao, Qingwei Meng, Yanbin Zhao, Xuesong Chen, Li Cai

Open Access Research article

SOX2 expression is associated with a cancer stem cell state and down-regulation of CDX2 in colorectal cancer

Ida V. Lundberg, Sofia Edin, Vincy Eklöf, Åke Öberg, Richard Palmqvist, Maria L. Wikberg

Open Access Research article

PROX1 and β-catenin are prognostic markers in pancreatic ductal adenocarcinoma

Kapo Saukkonen, Jaana Hagström, Harri Mustonen, Anne Juuti, Stig Nordling, Pauliina Kallio, Kari Alitalo, Hanna Seppänen, Caj Haglund

Open Access Research article

Modeling and simulation of maintenance treatment in first-line non-small cell lung cancer with external validation

Kelong Han, Laurent Claret, Alan Sandler, Asha Das, Jin Jin, Rene Bruno

Open Access Erratum

Erratum to: Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice

J. R. Hens, I. Sinha, F. Perodin, T. Cooper, R. Sinha, J. Plummer, C. E. Perrone, D. Orentreich

Open Access Research article

No preclinical rationale for IGF1R directed therapy in chondrosarcoma of bone

Elisabeth F. P. Peterse, Arjen H. G. Cleven, Yvonne De Jong, Inge Briaire-de Bruijn, Jonathan A. Fletcher, Erik H. J. Danen, Anne-Marie Cleton-Jansen, Judith V. M. G. Bovée

Open Access Research article

Bile acids destabilise HIF-1α and promote anti-tumour phenotypes in cancer cell models

J. P. Phelan, F. J. Reen, N. Dunphy, R. O’Connor, F. O’Gara

Open Access Technical advance

Method for semi-automated microscopy of filtration-enriched circulating tumor cells

Emma Pailler, Marianne Oulhen, Fanny Billiot, Alexandre Galland, Nathalie Auger, Vincent Faugeroux, Corinne Laplace-Builhé, Benjamin Besse, Yohann Loriot, Maud Ngo-Camus, Merouan Hemanda, Colin R. Lindsay, Jean-Charles Soria, Philippe Vielh, Françoise Farace

Open Access Research article

Clinicopathological features and prognosis of gastric cancer in young patients

Shushang Liu, Fan Feng, Guanghui Xu, Zhen Liu, Yangzi Tian, Man Guo, Xiao Lian, Lei Cai, Daiming Fan, Hongwei Zhang

Open Access Research article

Results of sub-analysis of a phase 2 study on trabectedin treatment for extraskeletal myxoid chondrosarcoma and mesenchymal chondrosarcoma

Hideo Morioka, Shunji Takahashi, Nobuhito Araki, Hideshi Sugiura, Takafumi Ueda, Mitsuru Takahashi, Tsukasa Yonemoto, Hiroaki Hiraga, Toru Hiruma, Toshiyuki Kunisada, Akihiko Matsumine, Michiro Susa, Robert Nakayama, Kazumasa Nishimoto, Kazutaka Kikuta, Keisuke Horiuchi, Akira Kawai

Open Access Research article

The Alberta Moving Beyond Breast Cancer (AMBER) Cohort Study: Recruitment, Baseline Assessment, and Description of the First 500 Participants

Kerry S. Courneya, Margaret L. McNeely, S. Nicole Culos-Reed, Jeff K. Vallance, Gordon J. Bell, John R. Mackey, Charles E. Matthews, Andria R. Morielli, Diane Cook, Sarah MacLaughlin, Megan S. Farris, Stephanie Voaklander, Rachel O’Reilly, Christine M. Friedenreich

Open Access Research article

Etoposide damages female germ cells in the developing ovary

Agnes Stefansdottir, Zoe C. Johnston, Nicola Powles-Glover, Richard A. Anderson, Ian R. Adams, Norah Spears

Open Access Research article

Osteopontin and thrombospondin-1 play opposite roles in promoting tumor aggressiveness of primary resected non-small cell lung cancer

Mathieu Rouanne, Julien Adam, Aïcha Goubar, Angélique Robin, Caroline Ohana, Emilie Louvet, Jiemin Cormier, Olaf Mercier, Peter Dorfmüller, Soly Fattal, Vincent Thomas de Montpreville, Thierry Lebret, Philippe Dartevelle, Elie Fadel, Benjamin Besse, Ken André Olaussen, Christian Auclair, Jean-Charles Soria

Open Access Research article

Determining intrafractional prostate motion using four dimensional ultrasound system

Mariwan Baker, Claus F. Behrens

Open Access Technical advance

Efficient generation of patient-matched malignant and normal primary cell cultures from clear cell renal cell carcinoma patients: clinically relevant models for research and personalized medicine

Nazleen C. Lobo, Craig Gedye, Anthony J. Apostoli, Kevin R. Brown, Joshua Paterson, Natalie Stickle, Michael Robinette, Neil Fleshner, Robert J. Hamilton, Girish Kulkarni, Alexandre Zlotta, Andrew Evans, Antonio Finelli, Jason Moffat, Michael A. S. Jewett, Laurie Ailles

Open Access Research article

Subcellular differential expression of Ep-ICD in oral dysplasia and cancer is associated with disease progression and prognosis

Raj Thani Somasundaram, Jatinder Kaur, Iona Leong, Christina MacMillan, Ian J. Witterick, Paul G. Walfish, Ranju Ralhan

Open Access Research article

Everolimus downregulates estrogen receptor and induces autophagy in aromatase inhibitor-resistant breast cancer cells

Asona Lui, Jacob New, Joshua Ogony, Sufi Thomas, Joan Lewis-Wambi

Open Access Research article

Chronic kidney disease and the risk of cancer: an individual patient data meta-analysis of 32,057 participants from six prospective studies

Germaine Wong, Natalie Staplin, Jonathan Emberson, Colin Baigent, Robin Turner, John Chalmers, Sophia Zoungas, Carol Pollock, Bruce Cooper, David Harris, Jie Jin. Wang, Paul Mitchell, Richard Prince, Wai Hon. Lim, Joshua Lewis, Jeremy Chapman, Jonathan Craig

Open Access Research article

MICAL1 controls cell invasive phenotype via regulating oxidative stress in breast cancer cells

Wenjie Deng, Yueyuan Wang, Luo Gu, Biao Duan, Jie Cui, Yujie Zhang, Yan Chen, Shixiu Sun, Jing Dong, Jun Du

Open Access Research article

The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis

Igor Snapkov, Carl Otto Öqvist, Yngve Figenschau, Per Kogner, John Inge Johnsen, Baldur Sveinbjørnsson

Open Access Research article

AT-101 enhances gefitinib sensitivity in non-small cell lung cancer with EGFR T790M mutations

Ren Zhao, Shun Zhou, Bing Xia, Cui-ying Zhang, Ping Hai, Hong Zhe, Yan-yang Wang

Open Access Research article

Identification of V-ATPase as a molecular sensor of SOX11-levels and potential therapeutic target for mantle cell lymphoma

Venera Kuci Emruli, Roger Olsson, Fredrik Ek, Sara Ek

Open Access Research article

Serum MMP7, MMP10 and MMP12 level as negative prognostic markers in colon cancer patients

Fee Klupp, Lena Neumann, Christoph Kahlert, Johannes Diers, Niels Halama, Clemens Franz, Thomas Schmidt, Moritz Koch, Juergen Weitz, Martin Schneider, Alexis Ulrich

Open Access Research article

MicroRNA-183 suppresses cancer stem-like cell properties in EBV-associated nasopharyngeal carcinoma

Chartia Ching-Mei Cheung, Samantha Wei-Man Lun, Grace Tin-Yun Chung, Chit Chow, Carman Lo, Kwong-Wai Choy, Kwok-Wai Lo

Open Access Research article

New anti-cancer chemicals Ertredin and its derivatives, regulate oxidative phosphorylation and glycolysis and suppress sphere formation in vitro and tumor growth in EGFRvIII-transformed cells

Sonoko Atsumi, Chisato Nosaka, Hayamitsu Adachi, Tomoyuki Kimura, Yoshihiko Kobayashi, Hisashi Takada, Takumi Watanabe, Shun-ichi Ohba, Hiroyuki Inoue, Manabu Kawada, Masakatsu Shibasaki, Masabumi Shibuya

Open Access Research article

Changes in mitochondrial stability during the progression of the Barrett’s esophagus disease sequence

N. J. O’Farrell, R. Feighery, S. L. Picardo, N. Lynam-Lennon, M. Biniecka, S. A. McGarrigle, J. J. Phelan, F. MacCarthy, D. O’Toole, E. J. Fox, N. Ravi, J. V. Reynolds, J. O’Sullivan

Open Access Research article

Are preoperative histology and MRI useful for classification of endometrial cancer risk?

Noemie Body, Vincent Lavoué, Olivier De Kerdaniel, Fabrice Foucher, Sébastien Henno, Aurélie Cauchois, Bruno Laviolle, Marc Leblanc, Jean Levêque

Open Access Study protocol

POSITIVE study: physical exercise program in non-operable lung cancer patients undergoing palliative treatment

Joachim Wiskemann, Simone Hummler, Christina Diepold, Melanie Keil, Ulrich Abel, Karen Steindorf, Philipp Beckhove, Cornelia M. Ulrich, Martin Steins, Michael Thomas

Open Access Study protocol

Phase II study of metformin for reduction of obesity-associated breast cancer risk: a randomized controlled trial protocol

Jessica A. Martinez, Pavani Chalasani, Cynthia A. Thomson, Denise Roe, Maria Altbach, Jean-Philippe Galons, Alison Stopeck, Patricia A. Thompson, Diana Evelyn Villa-Guillen, H-H. Sherry Chow

Open Access Research article

Combined chemoradiation of cisplatin versus carboplatin in cervical carcinoma: a single institution experience from Thailand

Ekkasit Tharavichitkul, Vicharn Lorvidhaya, Pimkhuan Kamnerdsupaphon, Vimol Sukthomya, Somvilai Chakrabandhu, Pitchayaponne Klunklin, Wimrak Onchan, Bongkoch Supawongwattana, Nantaka Pukanhaphan, Razvan Galalae, Imjai Chitapanarux

Open Access Research article

Galectin-3 interacts with components of the nuclear ribonucleoprotein complex

Katharina Fritsch, Marco Mernberger, Andrea Nist, Thorsten Stiewe, Alexander Brehm, Ralf Jacob

Open Access Study protocol

ESOPEC: prospective randomized controlled multicenter phase III trial comparing perioperative chemotherapy (FLOT protocol) to neoadjuvant chemoradiation (CROSS protocol) in patients with adenocarcinoma of the esophagus (NCT02509286)

Jens Hoeppner, Florian Lordick, Thomas Brunner, Torben Glatz, Peter Bronsert, Nadine Röthling, Claudia Schmoor, Dietmar Lorenz, Christian Ell, Ulrich T. Hopt, J. Rüdiger Siewert

Open Access Research article

CPA-7 influences immune profile and elicits anti-prostate cancer effects by inhibiting activated STAT3

Meihua Liang, Fei Zhan, Juan Zhao, Qi Li, Jiazi Wuyang, Guannan Mu, Dianjun Li, Yanqiao Zhang, Xiaoyi Huang

Open Access Research article

Prognostic value of quality of life score in disease-free survivors of surgically-treated lung cancer

Young Ho Yun, Young Ae Kim, Jin Ah Sim, Ae Sun Shin, Yoon Jung Chang, Jongmog Lee, Moon Soo Kim, Young Mog Shim, Jae lll Zo

Open Access Research article

Association of preoperative EpCAM Circulating Tumor Cells and peripheral Treg cell levels with early recurrence of hepatocellular carcinoma following radical hepatic resection

Yan Zhou, Beili Wang, Jiong Wu, Chunyan Zhang, Yiwen Zhou, XinRong Yang, Jian Zhou, Wei Guo, Jia Fan

Open Access Research article

Occult invasive cervical cancer after simple hysterectomy: a multi-center retrospective study of 89 cases

Huimin Bai, Dongyan Cao, Fang Yuan, Huilan Wang, Jie Chen, Yue Wang, Keng Shen, Zhenyu Zhang

Open Access Research article

ROR2 is epigenetically inactivated in the early stages of colorectal neoplasia and is associated with proliferation and migration

Sean S. Q. Ma, Sameer Srivastava, Estelle Llamosas, Nicholas J. Hawkins, Luke B. Hesson, Robyn L. Ward, Caroline E. Ford

Open Access Research article

Y90 Radioembolization in chemo-refractory metastastic, liver dominant colorectal cancer patients: outcome assessment applying a predictive scoring system

Robert Damm, Ricarda Seidensticker, Gerhard Ulrich, Leonie Breier, Ingo G. Steffen, Max Seidensticker, Benjamin Garlipp, Konrad Mohnike, Maciej Pech, Holger Amthauer, Jens Ricke

Open Access Research article

Cross-reactivity profiles of hybrid capture II, cobas, and APTIMA human papillomavirus assays: split-sample study

Sarah Preisler, Matejka Rebolj, Ditte Møller Ejegod, Elsebeth Lynge, Carsten Rygaard, Jesper Bonde

Open Access Research article

Prognostic significance of FOXM1 expression and antitumor effect of FOXM1 inhibition in synovial sarcomas

Akira Maekawa, Kenichi Kohashi, Masaaki Kuda, Kunio Iura, Takeaki Ishii, Makoto Endo, Tetsuya Nakatsura, Yukihide Iwamoto, Yoshinao Oda

Open Access Case report

NRASQ61K mutated primary leptomeningeal melanoma in a child: case presentation and discussion on clinical and diagnostic implications

Giulia Angelino, Maria Debora De Pasquale, Luigi De Sio, Annalisa Serra, Luca Massimi, Rita De Vito, Antonio Marrazzo, Laura Lancella, Andrea Carai, Manila Antonelli, Felice Giangaspero, Marco Gessi, Laura Menchini, Laura Scarciolla, Daniela Longo, Angela Mastronuzzi

Open Access Study protocol

A multi-centred randomised trial of radical surgery versus adjuvant chemoradiotherapy after local excision for early rectal cancer

W. A. A. Borstlap, P. J. Tanis, T. W. A. Koedam, C. A. M. Marijnen, C. Cunningham, E. Dekker, M. E. van Leerdam, G. Meijer, N. van Grieken, I. D. Nagtegaal, C. J. A. Punt, M. G. W. Dijkgraaf, J. H. De Wilt, G. Beets, E. J. de Graaf, A. A. W van Geloven, M. F. Gerhards, H. L. van Westreenen, A. W. H. van de Ven, P. van Duijvendijk, I. H. J. T. de Hingh, J. W. A. Leijtens, C. Sietses, E. J. Spillenaar-Bilgen, R. J. C. L. M. Vuylsteke, C. Hoff, J. W. A. Burger, W. M. U. van Grevenstein, A. Pronk, R. J. I. Bosker, H. Prins, A. B. Smits, S. Bruin, D. D. Zimmerman, L. P. S. Stassen, M. S. Dunker, M. Westerterp, P. P. Coene, J. Stoot, W. A. Bemelman, J. B. Tuynman

Open Access Research article

CXCL12 expression promotes esophageal squamous cell carcinoma proliferation and worsens the prognosis

Yusuke Uchi, Hiroya Takeuchi, Sachiko Matsuda, Yoshiro Saikawa, Hirofumi Kawakubo, Norihito Wada, Tsunehiro Takahashi, Rieko Nakamura, Kazumasa Fukuda, Tai Omori, Yuko Kitagawa

Open Access Research article

Prognostic impact of AJCC response criteria for neoadjuvant chemotherapy in stage II/III breast cancer patients: breast cancer subtype analyses

Yaewon Yang, Seock-Ah Im, Bhumsuk Keam, Kyung‑Hun Lee, Tae‑Yong Kim, Koung Jin Suh, Han Suk Ryu, Hyeong-Gon Moon, Sae‑Won Han, Do‑Youn Oh, Wonshik Han, Tae‑You Kim, In Ae Park, Dong-Young Noh

Open Access Research article

High level of serum apolipoprotein A-I is a favorable prognostic factor for overall survival in esophageal squamous cell carcinoma

Xue-Ping Wang, Xiao-Hui Li, Lin Zhang, Jian-Hua Lin, Hao Huang, Ting Kang, Min-Jie Mao, Hao Chen, Xin Zheng

Open Access Erratum

Erratum to: Survival, safety, and prognostic factors for outcome with Regorafenib in patients with metastatic colorectal cancer refractory to standard therapies: results from a multicenter study (REBECCA) nested within a compassionate use program

Antoine Adenis, Christelle de la Fouchardiere, Bernard Paule, Pascal Burtin, David Tougeron, Jennifer Wallet, Louis-Marie Dourthe, Pierre-Luc Etienne, Laurent Mineur, Stéphanie Clisant, Jean-Marc Phelip, Andrew Kramar, Thierry Andre

Open Access Research article

Predictive value of vrk 1 and 2 for rectal adenocarcinoma response to neoadjuvant chemoradiation therapy: a retrospective observational cohort study

Laura del Puerto-Nevado, Juan Pablo Marin-Arango, Maria Jesus Fernandez-Aceñero, David Arroyo-Manzano, Javier Martinez-Useros, Aurea Borrero-Palacios, Maria Rodriguez-Remirez, Arancha Cebrian, Teresa Gomez del Pulgar, Marlid Cruz-Ramos, Cristina Carames, Begoña Lopez-Botet, Jesús Garcia-Foncillas

Open Access Study protocol

The effectiveness of a nurse-led intervention with the distress thermometer for patients treated with curative intent for breast cancer: design of a randomized controlled trial

Floortje K. Ploos van Amstel, Judith B. Prins, Winette T. A. van der Graaf, Marlies E. W. J. Peters, Petronella B. Ottevanger

Open Access Research article

Comparison of the HER2, estrogen and progesterone receptor expression profile of primary tumor, metastases and circulating tumor cells in metastatic breast cancer patients

Bahriye Aktas, Sabine Kasimir-Bauer, Volkmar Müller, Wolfgang Janni, Tanja Fehm, Diethelm Wallwiener, Klaus Pantel, Mitra Tewes

Open Access Research article

Is monitoring of plasma 5-fluorouracil levels in metastatic / advanced colorectal cancer clinically effective? A systematic review

Karoline Freeman, Mark P. Saunders, Olalekan A. Uthman, Sian Taylor-Phillips, Martin Connock, Rachel Court, Tara Gurung, Paul Sutcliffe, Aileen Clarke

Open Access Research article

The combined expression of Semaphorin4D and PlexinB1 predicts disease recurrence in colorectal cancer

Tetsuro Ikeya, Kiyoshi Maeda, Hisashi Nagahara, Masatsune Shibutani, Yasuhito Iseki, Kosei Hirakawa

Open Access Research article

Real-time HER2 status detected on circulating tumor cells predicts different outcomes of anti-HER2 therapy in histologically HER2-positive metastatic breast cancer patients

Shaohua Zhang, Lei Li, Tao Wang, Li Bian, Haixu Hu, Chunhong Xu, Bing Liu, Yi Liu, Massimo Cristofanilli, Zefei Jiang

Open Access Research article

Survival and prognostic factors in patients with stable and unstable spinal bone metastases from solid tumors: a retrospective analysis of 915 cases

Robert J. Wolf, Robert Foerster, Thomas Bruckner, Tilman Bostel, Ingmar Schlampp, Juergen Debus, Harald Rief, German Bone Research Group

Open Access Research article

A cohort analysis of men with a family history of BRCA1/2 and Lynch mutations for prostate cancer

Lynne Kerr, Matthew J. Rewhorn, Mark Longmuir, Sioban Fraser, Shaun Walsh, Nicola Andrew, Hing Y. Leung

Open Access Research article

Foxp3 overexpression in tumor cells predicts poor survival in oral squamous cell carcinoma

Jing-Jing Song, Si-Jia Zhao, Juan Fang, Da Ma, Xiang-Qi Liu, Xiao-Bing Chen, Yun Wang, Bin Cheng, Zhi Wang

Open Access Research article

Pro-survival responses to the dual inhibition of anti-apoptotic Bcl-2 family proteins and mTOR-mediated signaling in hypoxic colorectal carcinoma cells

Karianne Risberg, Kathrine Røe Redalen, Linda Sønstevold, Tonje Bjørnetrø, Janne Sølvernes, Anne Hansen Ree

Open Access Research article

Saikosaponin d induces cell death through caspase-3-dependent, caspase-3-independent and mitochondrial pathways in mammalian hepatic stellate cells

Ming-Feng Chen, S. Joseph Huang, Chao-Cheng Huang, Pei-Shan Liu, Kun-I Lin, Ching-Wen Liu, Wen-Chuan Hsieh, Li-Yen Shiu, Chang-Han Chen

Open Access Research Article

Pseudo-HE images derived from CARS/TPEF/SHG multimodal imaging in combination with Raman-spectroscopy as a pathological screening tool

Thomas W. Bocklitz, Firas Subhi Salah, Nadine Vogler, Sandro Heuke, Olga Chernavskaia, Carsten Schmidt, Maximilian J. Waldner, Florian R. Greten, Rolf Bräuer, Michael Schmitt, Andreas Stallmach, Iver Petersen, Jürgen Popp

Open Access Research article

Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis

Sandra Fernandes Martins, Ricardo Amorim, Marta Viana-Pereira, Céline Pinheiro, Ricardo Filipe Alves Costa, Patrícia Silva, Carla Couto, Sara Alves, Sara Fernandes, Sónia Vilaça, Joaquim Falcão, Herlander Marques, Fernando Pardal, Mesquita Rodrigues, Ana Preto, Rui Manuel Reis, Adhemar Longatto-Filho, Fátima Baltazar

Open Access Research article

Circulating proteins in response to combined-modality therapy in rectal cancer identified by antibody array screening

Erta Kalanxhi, Helga Helseth Hektoen, Sebastian Meltzer, Svein Dueland, Kjersti Flatmark, Anne Hansen Ree

Open Access Research article

Rituximab plus chemotherapy as first-line treatment in Chinese patients with diffuse large B-cell lymphoma in routine practice: a prospective, multicentre, non-interventional study

Jianqiu Wu, Yongping Song, Liping Su, Li Xu, Tingchao Chen, Zhiyun Zhao, Mingzhi Zhang, Wei Li, Yu Hu, Xiaohong Zhang, Yuhuan Gao, Zuoxing Niu, Ru Feng, Wei Wang, Jiewen Peng, Xiaolin Li, Xuenong Ouyang, Changping Wu, Weijing Zhang, Yun Zeng, Zhen Xiao, Yingmin Liang, Yongzhi Zhuang, Jishi Wang, Zimin Sun, Hai Bai, Tongjian Cui, Jifeng Feng

Open Access Debate

Atypical ubiquitin ligase RNF31: the nuclear factor modulator in breast cancer progression

Jian Zhu, Ting Zhuang, Huijie Yang, Xin Li, Huandi Liu, Hui Wang

Open Access Research article

Transcriptome analysis of paired primary colorectal carcinoma and liver metastases reveals fusion transcripts and similar gene expression profiles in primary carcinoma and liver metastases

Ja-Rang Lee, Chae Hwa Kwon, Yuri Choi, Hye Ji Park, Hyun Sung Kim, Hong-Jae Jo, Nahmgun Oh, Do Youn Park

Open Access Research article

PAC down-regulates estrogen receptor alpha and suppresses epithelial-to-mesenchymal transition in breast cancer cells

Huda A. Al-Howail, Hana A. Hakami, Basem Al-Otaibi, Amer Al-Mazrou, Maha H. Daghestani, Ibrahim Al-Jammaz, Huda H. Al-Khalaf, Abdelilah Aboussekhra

Open Access Research article

The association of infrared imaging findings of the breast with prognosis in breast cancer patients: an observational cohort study

Li-An Wu, Wen-Hung Kuo, Chin-Yu Chen, Yuh-Show Tsai, Jane Wang

Open Access Research article

Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed

Boris Decarolis, Thorsten Simon, Barbara Krug, Ivo Leuschner, Christian Vokuhl, Peter Kaatsch, Dietrich von Schweinitz, Thomas Klingebiel, Ingo Mueller, Lothar Schweigerer, Frank Berthold, Barbara Hero

Open Access Case report

A case report: delayed high fever and maculopapules during Sorafenib treatment of ectopic hepatocellular carcinoma

Tianxiang Cui, Xinwei Diao, Xiewan Chen, Shaojiang Huang, Jianguo Sun

Open Access Research article

Bifidobacterial recombinant thymidine kinase-ganciclovir gene therapy system induces FasL and TNFR2 mediated antitumor apoptosis in solid tumors

Changdong Wang, Yongping Ma, Qiongwen Hu, Tingting Xie, Jiayan Wu, Fan Zeng, Fangzhou Song

Open Access Research article

Microsatellite alteration and immunohistochemical expression profile of chromosome 9p21 in patients with sporadic renal cell carcinoma following surgical resection

Ismail El-Mokadem, Alison Lim, Thomas Kidd, Katherine Garret, Norman Pratt, David Batty, Stewart Fleming, Ghulam Nabi

Open Access Research article

Angiogenic cytokines and their influence on circulating tumour cells in sera of patients with the primary diagnosis of breast cancer before treatment

Theresa Vilsmaier, Brigitte Rack, Wolfgang Janni, Udo Jeschke, Tobias Weissenbacher

Open Access Research article

Induction of artificial cancer stem cells from tongue cancer cells by defined reprogramming factors

Koji Harada, Tarannum Ferdous, Dan Cui, Yasuhiro Kuramitsu, Takuya Matsumoto, Eiji Ikeda, Hideyuki Okano, Yoshiya Ueyama

Open Access Research article

Expression of circadian clock genes and proteins in urothelial cancer is related to cancer-associated genes

Jorunn Litlekalsoy, Kari Rostad, Karl-Henning Kalland, Jens G. Hostmark, Ole Didrik Laerum

Open Access Research article

MK-2206 sensitizes BRCA-deficient epithelial ovarian adenocarcinoma to cisplatin and olaparib

Margaret E. Whicker, Z. Ping Lin, Ruth Hanna, Alan C. Sartorelli, Elena S. Ratner

Open Access Research article

Palmitate-induced ER stress increases trastuzumab sensitivity in HER2/neu-positive breast cancer cells

Jan Baumann, Jason Wong, Yan Sun, Douglas S. Conklin

Open Access Case report

A rare case of extremely high counts of circulating tumor cells detected in a patient with an oral squamous cell carcinoma

Xianglei Wu, Romina Mastronicola, Qian Tu, Gilbert Charles Faure, Marcelo De Carvalho Bittencourt, Gilles Dolivet

Open Access Research article

PIK3CA dependence and sensitivity to therapeutic targeting in urothelial carcinoma

R. L. Ross, H. R. McPherson, L. Kettlewell, S. D. Shnyder, C. D. Hurst, O. Alder, M. A. Knowles

Open Access Research article

Better survival in right-sided versus left-sided stage I - III colon cancer patients

Rene Warschkow, Michael C. Sulz, Lukas Marti, Ignazio Tarantino, Bruno M. Schmied, Thomas Cerny, Ulrich Güller

Open Access Research article

The effects of lymph node status on predicting outcome in ER+ /HER2- tamoxifen treated breast cancer patients using gene signatures

Jessica G. Cockburn, Robin M. Hallett, Amy E. Gillgrass, Kay N. Dias, T. Whelan, M. N. Levine, John A. Hassell, Anita Bane

Open Access Research article

Pre-treatment MRI minimum apparent diffusion coefficient value is a potential prognostic imaging biomarker in cervical cancer patients treated with definitive chemoradiation

Daniel Grossi Marconi, Jose Humberto Tavares Guerreiro Fregnani, Rodrigo Ribeiro Rossini, Ana Karina Borges Junqueira Netto, Fabiano Rubião Lucchesi, Audrey Tieko Tsunoda, Mitchell Kamrava

Open Access Research article

The impact of body mass index on treatment outcomes for patients with low-intermediate risk prostate cancer

Kosj Yamoah, Charnita M. Zeigler-Johnson, Abra Jeffers, Bruce Malkowicz, Elaine Spangler, Jong Y. Park, Alice Whittemore, Timothy R. Rebbeck

Open Access Research article

Return to work after cancer treatment of gynecologic cancer in Japan

Keiichiro Nakamura, Hisashi Masuyama, Takeshi Nishida, Junko Haraga, Naoyuki Ida, Masayuki Saijo, Tomoko Haruma, Tomoyuki Kusumoto, Noriko Seki, Yuji Hiramatsu

Open Access Research article

Increased sensitivity of African American triple negative breast cancer cells to nitric oxide-induced mitochondria-mediated apoptosis

Luis Martinez, Easter Thames, Jinna Kim, Gautam Chaudhuri, Rajan Singh, Shehla Pervin

Open Access Research article

Single nucleotide polymorphism rs13042395 in the SLC52A3 gene as a biomarker for regional lymph node metastasis and relapse-free survival of esophageal squamous cell carcinoma patients

Hua-Zhen Tan, Zhi-Yong Wu, Jian-Yi Wu, Lin Long, Ji-Wei Jiao, Yu-Hui Peng, Yi-Wei Xu, Shan-Shan Li, Wei Wang, Jian-Jun Zhang, En-Min Li, Li-Yan Xu

Open Access Research article

Heat shock protein 70–2 (HSP70-2) is a novel therapeutic target for colorectal cancer and is associated with tumor growth

Nirmala Jagadish, Deepak Parashar, Namita Gupta, Sumit Agarwal, Vaishali Suri, Rajive Kumar, Vitusha Suri, Trilok Chand Sadasukhi, Anju Gupta, Abdul S. Ansari, Nirmal Kumar Lohiya, Anil Suri

Open Access Research article

Coffee consumption and the risk of malignant melanoma in the Norwegian Women and Cancer (NOWAC) Study

Marko Lukic, Mie Jareid, Elisabete Weiderpass, Tonje Braaten

Open Access Debate

Primary extramammary invasive Paget’s vulvar disease: what is the standard, what are the challenges and what is the future for radiotherapy?

Maria Tolia, Nikolaos Tsoukalas, Chrisostomos Sofoudis, Constantinos Giaginis, Despoina Spyropoulou, Dimitrios Kardamakis, Vasileios Kouloulias, George Kyrgias

Open Access Research article

The occurrence of hyponatremia and its importance as a prognostic factor in a cross-section of cancer patients

Jorge J. Castillo, Ilya G. Glezerman, Susan H. Boklage, Joseph Chiodo III, Beni A. Tidwell, Lois E. Lamerato, Kathy L. Schulman

Open Access Research article

Mesenchymal stem cells enhance the metastasis of 3D-cultured hepatocellular carcinoma cells

Chang Liu, Yang Liu, Xiao-xi Xu, Xin Guo, Guang-wei Sun, Xiao-jun Ma

Open Access Research article

Socio-economic deprivation: a significant determinant affecting stage of oral cancer diagnosis and survival

Ajit Auluck, Blake Byron Walker, Greg Hislop, Scott A. Lear, Nadine Schuurman, Miriam Rosin

Open Access Research article

CPP2-p16MIS treatment–induced colon carcinoma cell death in vitro and prolonged lifespan of tumor-bearing mice

Lifeng Wang, Haijin Chen, Jinlong Yu, Xiaohua Lin, Jia Qi, Chunhui Cui, Lang Xie, Shuxin Huang

Open Access Technical advance

In chronic myeloid leukemia patients on second-line tyrosine kinase inhibitor therapy, deep sequencing of BCR-ABL1 at the time of warning may allow sensitive detection of emerging drug-resistant mutants

Simona Soverini, Caterina De Benedittis, Fausto Castagnetti, Gabriele Gugliotta, Manuela Mancini, Luana Bavaro, Katerina Machova Polakova, Jana Linhartova, Alessandra Iurlo, Domenico Russo, Fabrizio Pane, Giuseppe Saglio, Gianantonio Rosti, Michele Cavo, Michele Baccarani, Giovanni Martinelli

Open Access Case report

A HELLP syndrome complicates a gestational trophoblastic neoplasia in a perimenopausal woman: a case report

Guillaume Vogin, François Golfier, Touria Hajri, Agnès Leroux, Béatrice Weber

Open Access Research article

CHEK2 represses breast stromal fibroblasts and their paracrine tumor-promoting effects through suppressing SDF-1 and IL-6

Maha A. Al-Rakan, Siti-Faujiah Hendrayani, Abdelilah Aboussekhra

Open Access Research article

Reproducibility and uptake time dependency of volume-based parameters on FDG-PET for lung cancer

Tomoka Kitao, Kenji Hirata, Katsumi Shima, Takashi Hayashi, Mitsunori Sekizawa, Toshiki Takei, Wataru Ichimura, Masao Harada, Keishi Kondo, Nagara Tamaki

Open Access Research article

Emodin enhances cisplatin-induced cytotoxicity in human bladder cancer cells through ROS elevation and MRP1 downregulation

Xinxing Li, Haolu Wang, Juan Wang, Yuying Chen, Xiaobin Yin, Guiying Shi, Hui Li, Zhiqian Hu, Xiaowen Liang

Open Access Research article

Health services research of integrative oncology in palliative care of patients with advanced pancreatic cancer

Jan Axtner, Megan Steele, Matthias Kröz, Günther Spahn, Harald Matthes, Friedemann Schad

Open Access Study protocol

Effectiveness and cost-utility of a guided self-help exercise program for patients treated with total laryngectomy: protocol of a multi-center randomized controlled trial

Femke Jansen, Ingrid C. Cnossen, Simone E. J. Eerenstein, Veerle M. H. Coupé, Birgit I. Witte, Cornelia F. van Uden-Kraan, Patricia Doornaert, Weibel W. Braunius, Remco De Bree, José A. U. Hardillo, Jimmie Honings, György B. Halmos, C. René Leemans, Irma M. Verdonck-de Leeuw

Open Access Research article

Recapitulating epithelial tumor microenvironment in vitro using three dimensional tri-culture of human epithelial, endothelial, and mesenchymal cells

Surya P. Lamichhane, Neha Arya, Esther Kohler, Shengnan Xiang, Jon Christensen, V. Prasad Shastri

Open Access Research article

Inhibition of nuclear factor-kappa B enhances the tumor growth of ovarian cancer cell line derived from a low-grade papillary serous carcinoma in p53-independent pathway

Xue Xiao, Gong Yang, Peng Bai, Shunping Gui, Tri M. Bui Nyuyen, Imelda Mercado-Uribe, Mei Yang, Juan Zou, Qintong Li, Jianguo Xiao, Bin Chang, Guangzhi Liu, He Wang, Jinsong Liu

Open Access Research article

Long noncoding RNA TUG1 is downregulated in non-small cell lung cancer and can regulate CELF1 on binding to PRC2

Pei-Chin Lin, Hsien-Da Huang, Chun-Chi Chang, Ya-Sian Chang, Ju-Chen Yen, Chien-Chih Lee, Wen-Hsin Chang, Ta-Chih Liu, Jan-Gowth Chang

Open Access Research article

Quantitative proteomic analysis for novel biomarkers of buccal squamous cell carcinoma arising in background of oral submucous fibrosis

Wen Liu, Lijuan Zeng, Ning Li, Fei Wang, Canhua Jiang, Feng Guo, Xinqun Chen, Tong Su, Chunjiao Xu, Shanshan Zhang, Changyun Fang

Open Access Research article

A rational two-step approach to KRAS mutation testing in colorectal cancer using high resolution melting analysis and pyrosequencing

Elisabeth Mack, Kathleen Stabla, Jorge Riera-Knorrenschild, Roland Moll, Andreas Neubauer, Cornelia Brendel

Open Access Study protocol

An exploration of men’s experiences of undergoing active surveillance for favourable-risk prostate cancer: A mixed methods study protocol

Eimear Ruane-McAteer, Joe O’Sullivan, Sam Porter, Lionne Venderbos, Gillian Prue

Open Access Research article

Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer

Qing-Bai She, Sofia K. Gruvberger-Saal, Matthew Maurer, Yilun Chen, Mervi Jumppanen, Tao Su, Meaghan Dendy, Ying-Ka Ingar Lau, Lorenzo Memeo, Hugo M. Horlings, Marc J. van de Vijver, Jorma Isola, Hanina Hibshoosh, Neal Rosen, Ramon Parsons, Lao H. Saal

Open Access Case report

Radiation recall gastritis secondary to combination of gemcitabine and erlotinib in pancreatic cancer and response to PPI - a case report

Seong Ji Choi, Hyo Jung Kim, Jae Seon Kim, Young-Tae Bak, Jun Suk Kim

Open Access Research article

Evaluation of folate receptor 1 (FOLR1) mRNA expression, its specific promoter methylation and global DNA hypomethylation in type I and type II ovarian cancers

Sara Notaro, Daniel Reimer, Heidi Fiegl, Gabriel Schmid, Annamarie Wiedemair, Julia Rössler, Christian Marth, Alain Gustave Zeimet

Open Access Research article

“Safety and utility of percutaneous liver biopsy in hematopoietic stem cell transplant pediatric recipients: a retrospective study”

Natalia Maximova, Massimo Gregori, Francesca Barbieri, Antonio Pizzol, Aurelio Sonzogni

Open Access Research article

Chemotherapy and radiation therapy elicits tumor specific T cell responses in a breast cancer patient

David Bernal-Estévez, Ramiro Sánchez, Rafael E. Tejada, Carlos Parra-López

Open Access Case report

Pulmonary melanoma and “crazy paving” patterns in chest images: a case report and literature review

Yikuan Feng, Jianping Zhao, Qun Yang, Weining Xiong, Guohua Zhen, Yongjian Xu, Zhenxiang Zhang, Huilan Zhang

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Casein kinase 1α has a non-redundant and dominant role within the CK1 family in melanoma progression

Tobias Sinnberg, Jun Wang, Birgit Sauer, Birgit Schittek

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L1CAM as a prognostic marker in stage I endometrial cancer: a validation study

Elisabeth Smogeli, Ben Davidson, Milada Cvancarova, Arild Holth, Betina Katz, Bjørn Risberg, Gunnar Kristensen, Kristina Lindemann

Open Access Research article

Fibrillin-1 (FBN-1) a new marker of germ cell neoplasia in situ

Z. Cierna, M. Mego, I. Jurisica, K. Machalekova, M. Chovanec, V. Miskovska, D. Svetlovska, K. Kalavska, K. Rejlekova, K. Kajo, J. Mardiak, P. Babal

Open Access Research article

Comparison of detection methods and follow-up study on the tyrosine kinase inhibitors therapy in non-small cell lung cancer patients with ROS1 fusion rearrangement

Jieyu Wu, Yunen Lin, Xinming He, Haihong Yang, Ping He, Xinge Fu, Guangqiu Li, Xia Gu

Open Access Research article

Statin use and breast cancer survival: a nationwide cohort study in Scotland

Úna C. Mc Menamin, Liam J. Murray, Carmel M. Hughes, Chris R. Cardwell

Open Access Study protocol

Efficacy of night-time compression for breast cancer related lymphedema (LYNC): protocol for a multi-centre, randomized controlled efficacy trial

Margaret L. McNeely, Kristin L. Campbell, Marc Webster, Urve Kuusk, Karen Tracey, John Mackey

Open Access Research article

S6Ks isoforms contribute to viability, migration, docetaxel resistance and tumor formation of prostate cancer cells

Camila L. Amaral, Lidia B. Freitas, Rodrigo E. Tamura, Mariana R. Tavares, Isadora C. B. Pavan, Marcio C. Bajgelman, Fernando M. Simabuco

Open Access Research article

Inconsistent results in the analysis of ALK rearrangements in non-small cell lung cancer

Johanna S. M. Mattsson, Hans Brunnström, Verena Jabs, Karolina Edlund, Karin Jirström, Stephanie Mindus, Linnéa la Fleur, Fredrik Pontén, Mats G. Karlsson, Christina Karlsson, Hirsh Koyi, Eva Brandén, Johan Botling, Gisela Helenius, Patrick Micke, Maria A. Svensson

Open Access Research article

A radiosensitizing effect of RAD51 inhibition in glioblastoma stem-like cells

Anaïs Balbous, Ulrich Cortes, Karline Guilloteau, Pierre Rivet, Baptiste Pinel, Mathilde Duchesne, Julie Godet, Odile Boissonnade, Michel Wager, René Jean Bensadoun, Jean-Claude Chomel, Lucie Karayan-Tapon

Open Access Research article

MicroRNA-21 promotes proliferation, migration, and invasion of colorectal cancer, and tumor growth associated with down-regulation of sec23a expression

Chenli Li, Lingxu Zhao, Yuan Chen, Tiantian He, Xiaowan Chen, Jiating Mao, Chunmei Li, Jianxin Lyu, Qing H. Meng

Open Access Research article

A nomogram for predicting pathological complete response in patients with human epidermal growth factor receptor 2 negative breast cancer

Xi Jin, Yi-Zhou Jiang, Sheng Chen, Ke-Da Yu, Ding Ma, Wei Sun, Zhi-Min Shao, Gen-Hong Di

Open Access Research article

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Rasa Ruseckaite, Kerri Beckmann, Michael O’Callaghan, David Roder, Kim Moretti, Jeremy Millar, Sue Evans

Open Access Erratum

Erratum to: Conformational changes and translocation of tissue-transglutaminase to the plasma membranes: role in cancer cell migration

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Imaging-genomics reveals driving pathways of MRI derived volumetric tumor phenotype features in Glioblastoma

Patrick Grossmann, David A. Gutman, William D. Dunn Jr, Chad A. Holder, Hugo J. W. L. Aerts

Open Access Research article

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Gabriella D. Cozzi, Jacob M. Samuel, Jason T. Fromal, Spencer Keene, Marta A. Crispens, Dineo Khabele, Alicia Beeghly-Fadiel

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Risk factors associated with early mortality in patients with multiple myeloma who were treated upfront with a novel agents containing regimen

Sung-Hoon Jung, Min-Seok Cho, Hee Kyung Kim, Seok Jin Kim, Kihyun Kim, June-Won Cheong, Soo-Jeoong Kim, Jin Seok Kim, Jae-Sook Ahn, Yeo-Kyeoung Kim, Deok-Hwan Yang, Hyeoung-Joon Kim, Je-Jung Lee

Open Access Research article

Nanoroughened adhesion-based capture of circulating tumor cells with heterogeneous expression and metastatic characteristics

Weiqiang Chen, Steven G. Allen, Ajaya Kumar Reka, Weiyi Qian, Shuo Han, Jianing Zhao, Liwei Bao, Venkateshwar G. Keshamouni, Sofia D. Merajver, Jianping Fu

Open Access Research article

uPAR enhances malignant potential of triple-negative breast cancer by directly interacting with uPA and IGF1R

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Pazolimus: pazopanib plus sirolimus following progression on pazopanib, a retrospective case series analysis

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Swathi Ramakrishnan, ShengYu Ku, Eric Ciamporcero, Kiersten Marie Miles, Kris Attwood, Sreenivasulu Chintala, Li Shen, Leigh Ellis, Paula Sotomayor, Wendy Swetzig, Ray Huang, Dylan Conroy, Ashley Orillion, Gokul Das, Roberto Pili

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Open Access Research article

Efficacy and safety of Dexrazoxane (DRZ) in sarcoma patients receiving high cumulative doses of anthracycline therapy – a retrospective study including 32 patients

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Open Access Research article

Optimizing the process of fertility preservation in pediatric female cancer patients – a multidisciplinary program

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Open Access Research article

An evaluation in vitro of PARP-1 inhibitors, rucaparib and olaparib, as radiosensitisers for the treatment of neuroblastoma

Donna L. Nile, Colin Rae, Iain J. Hyndman, Mark N. Gaze, Robert J. Mairs

Open Access Research article

AKT1 E17K mutation profiling in breast cancer: prevalence, concurrent oncogenic alterations, and blood-based detection

Marion Rudolph, Tobias Anzeneder, Anke Schulz, Georg Beckmann, Annette T. Byrne, Michael Jeffers, Carol Pena, Oliver Politz, Karl Köchert, Richardus Vonk, Joachim Reischl

Open Access Research article

IAP antagonists Birinapant and AT-406 efficiently synergise with either TRAIL, BRAF, or BCL-2 inhibitors to sensitise BRAFV600E colorectal tumour cells to apoptosis

Philippos Perimenis, Apostolos Galaris, Alexandra Voulgari, Margarita Prassa, Alexander Pintzas

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Gd-EOB-DTPA-enhanced magnetic resonance imaging combined with T1 mapping predicts the degree of differentiation in hepatocellular carcinoma

Zhenpeng Peng, Mengjie Jiang, Huasong Cai, Tao Chan, Zhi Dong, Yanji Luo, Zi-Ping Li, Shi-Ting Feng

Open Access Research article

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Open Access Case report

A germline mutation of CDKN2A and a novel RPLP1-C19MC fusion detected in a rare melanotic neuroectodermal tumor of infancy: a case report

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Open Access Research article

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Open Access Research article

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Metformin use and its effect on survival in diabetic patients with advanced non-small cell lung cancer

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Open Access Research article

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Shiro Watanabe, Osamu Manabe, Kenji Hirata, Noriko Oyama-Manabe, Naoya Hattori, Yasuka Kikuchi, Kentaro Kobayashi, Takuya Toyonaga, Nagara Tamaki

Open Access Research article

The deficiency of galectin-3 in stromal cells leads to enhanced tumor growth and bone marrow metastasis

Jonathas Xavier Pereira, Maria Carolina Braga Azeredo, Felipe Sá Martins, Roger Chammas, Felipe Leite Oliveira, Sofia Nascimento Santos, Emerson Soares Bernardes, Márcia Cury El-Cheikh

Open Access Research article

Nurse-led group consultation intervention reduces depressive symptoms in men with localised prostate cancer: a cluster randomised controlled trial

Penelope Schofield, Karla Gough, Kerryann Lotfi-Jam, Rebecca Bergin, Anna Ugalde, Paul Dudgeon, Wallace Crellin, Kathryn Schubach, Farshard Foroudi, Keen Hun Tai, Gillian Duchesne, Rob Sanson-Fisher, Sanchia Aranda

Open Access Research article

Characterization of VHL missense mutations in sporadic clear cell renal cell carcinoma: hotspots, affected binding domains, functional impact on pVHL and therapeutic relevance

Caroline Razafinjatovo, Svenja Bihr, Axel Mischo, Ursula Vogl, Manuela Schmidinger, Holger Moch, Peter Schraml

Open Access Research article

MPO density in primary cancer biopsies of ovarian carcinoma enhances the indicative value of IL-17 for chemosensitivity

Raoul A. Droeser, Robert Mechera, Silvio Däster, Benjamin Weixler, Marko Kraljević, Tarik Delko, Uwe Güth, Sylvia Stadlmann, Luigi Terracciano, Gad Singer

Open Access Study protocol

A phase I/II clinical trial for the hybrid of intracavitary and interstitial brachytherapy for locally advanced cervical cancer

Naoya Murakami, Shingo Kato, Takashi Nakano, Takashi Uno, Takeharu Yamanaka, Hideyuki Sakurai, Ryoichi Yoshimura, Junichi Hiratsuka, Yuki Kuroda, Kotaro Yoshio, Jun Itami

Open Access Research article

Heterogeneity of ERG expression in prostate cancer: a large section mapping study of entire prostatectomy specimens from 125 patients

Maria-Christina Tsourlakis, Annegret Stender, Alexander Quaas, Martina Kluth, Corinna Wittmer, Alexander Haese, Markus Graefen, Stefan Steurer, Ronald Simon, Jan Korbel, Joachim Weischenfeldt, Hartwig Huland, Guido Sauter, Thorsten Schlomm, Sarah Minner

Open Access Research article

Type 2 diabetes mellitus and risk of colorectal adenoma: a meta-analysis of observational studies

Feifei Yu, Yibin Guo, Hao Wang, Jian Feng, Zhichao Jin, Qi Chen, Yu Liu, Jia He

Open Access Research article

Cholesterol and prostate cancer risk: a long-term prospective cohort study

Trond Heir, Ragnhild Sørum Falk, Trude Eid Robsahm, Leiv Sandvik, Jan Erikssen, Steinar Tretli

Open Access Study protocol

A phase 1 ‘window-of-opportunity’ trial testing evofosfamide (TH-302), a tumour-selective hypoxia-activated cytotoxic prodrug, with preoperative chemoradiotherapy in oesophageal adenocarcinoma patients

Ruben T. H. M. Larue, Lien Van De Voorde, Maaike Berbée, Wouter J. C. van Elmpt, Ludwig J. Dubois, Kranthi M. Panth, Sarah G. J. A. Peeters, Ann Claessens, Wendy M. J. Schreurs, Marius Nap, Fabiënne A. R. M. Warmerdam, Frans L. G. Erdkamp, Meindert N. Sosef, Philippe Lambin

Open Access Research article

Low dose DTIC is effective and safe in pretreated patients with well differentiated neuroendocrine tumors

Daniela Mueller, Sebastian Krug, Moushumee Majumder, Anja Rinke, Thomas Matthias Gress

Open Access Research article

Shifting patterns of genomic variation in the somatic evolution of papillary thyroid carcinoma

Jill C. Rubinstein, Taylor C. Brown, Emily R. Christison-Lagay, Yawei Zhang, John W. Kunstman, C. Christofer Juhlin, Carol Nelson-Williams, Gerald Goh, Courtney E. Quinn, Glenda G. Callender, Robert Udelsman, Richard P. Lifton, Reju Korah, Tobias Carling

Open Access Research article

Polo-like Kinase 1 as a potential therapeutic target in Diffuse Intrinsic Pontine Glioma

Vladimir Amani, Eric W Prince, Irina Alimova, Ilango Balakrishnan, Diane Birks, Andrew M. Donson, Peter Harris, Jean M. Mulcahy Levy, Michael Handler, Nicholas K. Foreman, Sujatha Venkataraman, Rajeev Vibhakar

Open Access Research article

BCL9L expression in pancreatic neoplasia with a focus on SPN: a possible explanation for the enigma of the benign neoplasia

Cora Hallas, Julia Phillipp, Lukas Domanowsky, Bettina Kah, Katharina Tiemann

Open Access Research article

p53, cathepsin D, Bcl-2 are joint prognostic indicators of breast cancer metastatic spreading

Emanuela Guerra, Alessia Cimadamore, Pasquale Simeone, Giovanna Vacca, Rossano Lattanzio, Gerardo Botti, Valentina Gatta, Marco D’Aurora, Barbara Simionati, Mauro Piantelli, Saverio Alberti

Open Access Research article

Original article: role of adjuvant chemotherapy in a perioperative chemotherapy regimen for gastric cancer

Sven Lichthardt, Alexander Kerscher, Ulrich A. Dietz, Christian Jurowich, Volker Kunzmann, Burkhard H. A. von Rahden, Christoph-Thomas Germer, Armin Wiegering

Open Access Research article

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Anastasia S. Proskurina, Tatiana S. Gvozdeva, Ekaterina A. Potter, Evgenia V. Dolgova, Konstantin E. Orishchenko, Valeriy P. Nikolin, Nelly A. Popova, Sergey V. Sidorov, Elena R. Chernykh, Alexandr A. Ostanin, Olga Y. Leplina, Victoria V. Dvornichenko, Dmitriy M. Ponomarenko, Galina S. Soldatova, Nikolay A. Varaksin, Tatiana G. Ryabicheva, Peter N. Uchakin, Vladimir A. Rogachev, Mikhail A. Shurdov, Sergey S. Bogachev

Open Access Study protocol

Connect MDS/AML: design of the myelodysplastic syndromes and acute myeloid leukemia disease registry, a prospective observational cohort study

David P. Steensma, Medrdad Abedi, Rafael Bejar, Christopher R. Cogle, Kathryn Foucar, Guillermo Garcia-Manero, Tracy I. George, David Grinblatt, Rami Komrokji, Xiaomei Ma, Jaroslaw Maciejewski, Daniel A. Pollyea, Michael R. Savona, Bart Scott, Mikkael A. Sekeres, Michael A. Thompson, Arlene S. Swern, Melissa Nifenecker, Mary M. Sugrue, Harry Erba

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Prognostic value of HER2 status in bladder transitional cell carcinoma revealed by both IHC and BDISH techniques

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Open Access Research article

Dynamic changes of tumor gene expression during repeated pressurized intraperitoneal aerosol chemotherapy (PIPAC) in women with peritoneal cancer

Günther A. Rezniczek, Friederike Jüngst, Hendrik Jütte, Andrea Tannapfel, Ziad Hilal, Lukas A. Hefler, Marc-André Reymond, Clemens B. Tempfer

Open Access Research article

Increased long noncoding RNA SNHG20 predicts poor prognosis in colorectal cancer

Cong Li, Li Zhou, Jun He, Xue-Qing Fang, Shao-Wen Zhu, Mao-Ming Xiong

Open Access Case report

Pembrolizumab-associated minimal change disease in a patient with malignant pleural mesothelioma

Angelika Bickel, Irene Koneth, Annette Enzler-Tschudy, Jörg Neuweiler, Lukas Flatz, Martin Früh

Open Access Research article

Dactolisib (NVP-BEZ235) toxicity in murine brain tumour models

I. A. Netland, H. E. Førde, L. Sleire, L. Leiss, M. A. Rahman, B. S. Skeie, C. H. Gjerde, P. Ø. Enger, D. Goplen

Open Access Research article

Nomograms to predict survival after colorectal cancer resection without preoperative therapy

Zhen-yu Zhang, Qi-feng Luo, Xiao-wei Yin, Zhen-ling Dai, Shiva Basnet, Hai-yan Ge

Open Access Research article

Use of non-steroidal anti-inflammatory drugs and risk of breast cancer: The Spanish Multi-Case-control (MCC) study

Trinidad Dierssen-Sotos, Inés Gómez-Acebo, María de Pedro, Beatriz Pérez-Gómez, Sonia Servitja, Víctor Moreno, Pilar Amiano, Tania Fernandez-Villa, Aurelio Barricarte, Adonina Tardon, Marian Diaz-Santos, Rosana Peiro-Perez, Rafael Marcos-Gragera, Virginia Lope, Esther Gracia-Lavedan, M. Henar Alonso, Maria Jesus Michelena-Echeveste, Andrés Garcia-Palomo, Marcela Guevara, Gemma Castaño-Vinyals, Nuria Aragonés, Manolis Kogevinas, Marina Pollán, Javier Llorca

Open Access Research article

Is there any role of intravenous iron for the treatment of anemia in cancer?

Cengiz Gemici, Ozlem Yetmen, Gokhan Yaprak, Sevgi Ozden, Huseyin Tepetam, Hazan Ozyurt, Alpaslan Mayadagli

Open Access Research article

Environmental, maternal, and reproductive risk factors for childhood acute lymphoblastic leukemia in Egypt: a case-control study

Sameera Ezzat, Wafaa M. Rashed, Sherin Salem, M. Tevfik Dorak, Mai El-Daly, Mohamed Abdel-Hamid, Iman Sidhom, Alaa El-Hadad, Christopher Loffredo

Open Access Research article

SPARC expression in patients with high-risk localized soft tissue sarcoma treated on a randomized phase II trial of neo/adjuvant chemotherapy

Elizabeth J. Davis, Lili Zhao, David R. Lucas, Scott M. Schuetze, Laurence H. Baker, Mark M. Zalupski, Dafydd Thomas, Rashmi Chugh

Open Access Research article

Effect of diagnostic delay on survival in patients with colorectal cancer: a retrospective cohort study

Salvador Pita-Fernández, Luis González-Sáez, Beatriz López-Calviño, Teresa Seoane-Pillado, Elena Rodríguez-Camacho, Alejandro Pazos-Sierra, Paloma González-Santamaría, Sonia Pértega-Díaz

Open Access Research article

Interleukin 12 shows a better curative effect on lung cancer than paclitaxel and cisplatin doublet chemotherapy

Ting Yue, Xiaodong Zheng, Yaling Dou, Xiaohu Zheng, Rui Sun, Zhigang Tian, Haiming Wei

Open Access Case report

Antemortem diagnosis of pulmonary tumor thrombotic microangiopathy in a patient with recurrent breast cancer: a case report

Yui Takahashi, Hironori Uruga, Takeshi Fujii, Sayaka Mochizuki, Shigeo Hanada, Hisashi Takaya, Atsushi Miyamoto, Nasa Morokawa, Atsuko Kurosaki, Kazuma Kishi

Open Access Research article

Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity

María Díaz-Núñez, Alejandro Díez-Torre, Olivier De Wever, Ricardo Andrade, Jon Arluzea, Margarita Silió, Juan Aréchaga

Open Access Research article

Performance and prognostic utility of the 92-gene assay in the molecular subclassification of ampullary adenocarcinoma

Michael J. Overman, Harris S. Soifer, Aaron Joel Schueneman, Joe Ensor Jr, Volkan Adsay, Burcu Saka, Nastaran Neishaboori, Robert A. Wolff, Huamin Wang, Catherine A. Schnabel, Gauri Varadhachary

Open Access Research article

Expression of EIF5A2 associates with poor survival of nasopharyngeal carcinoma patients treated with induction chemotherapy

Pei-Yu Huang, Ting-Ting Zeng, Xiaojiao Ban, Meng-Qing Li, Bao-Zhu Zhang, Ying-Hui Zhu, Wen-Feng Hua, Hai-Qiang Mai, Li Zhang, Xin-Yuan Guan, Yan Li

Open Access Research article

The transcriptional regulator TBX3 promotes progression from non-invasive to invasive breast cancer

Milica Krstic, Connor D. Macmillan, Hon S. Leong, Allen G. Clifford, Lesley H. Souter, David W. Dales, Carl O. Postenka, Ann F. Chambers, Alan B. Tuck

Open Access Research article

Predicting clinical outcomes in chordoma patients receiving immunotherapy: a comparison between volumetric segmentation and RECIST

Kathleen E. Fenerty, Les R. Folio, Nicholas J. Patronas, Jennifer L. Marté, James L. Gulley, Christopher R. Heery

Open Access Research article

High prevalence and predominance of BRCA1 germline mutations in Pakistani triple-negative breast cancer patients

Muhammad Usman Rashid, Noor Muhammad, Seerat Bajwa, Saima Faisal, Muhammad Tahseen, Justo Lorenzo Bermejo, Asim Amin, Asif Loya, Ute Hamann

Open Access Research article

Role of vitamin D receptor gene Cdx2 and Apa1 polymorphisms in prostate cancer susceptibility: a meta-analysis

Kewei Wang, Guosheng Wu, Jinping Li, Wentao Song

Open Access Research article

Outcomes of uterine sarcoma found incidentally after uterus-preserving surgery for presumed benign disease

Jung-Yun Lee, Hyun Soo Kim, Eun Ji Nam, Sang Wun Kim, Sunghoon Kim, Young Tae Kim

Open Access Research article

Identification of SEC62 as a potential marker for 3q amplification and cellular migration in dysplastic cervical lesions

Maximilian Linxweiler, Florian Bochen, Bernhard Schick, Silke Wemmert, Basel Al Kadah, Markus Greiner, Andrea Hasenfus, Rainer-Maria Bohle, Ingolf Juhasz-Böss, Erich-Franz Solomayer, Zoltan Ferenc Takacs

Open Access Research article

Efficacy and safety of bevacizumab plus chemotherapy compared to chemotherapy alone in previously untreated advanced or metastatic colorectal cancer: a systematic review and meta-analysis

Tobias Engel Ayer Botrel, Luciana Gontijo de Oliveira Clark, Luciano Paladini, Otávio Augusto C. Clark

Open Access Research article

Identification of therapeutic targets applicable to clinical strategies in ovarian cancer

Marianne K. Kim, Natasha Caplen, Sirisha Chakka, Lidia Hernandez, Carrie House, Georgios Pongas, Elizabeth Jordan, Christina M. Annunziata

Open Access Case report

Auto-immune thyroid dysfunction induced by tyrosine kinase inhibitors in a patient with recurrent chordoma

Juliette Eroukhmanoff, Frederic Castinetti, Nicolas Penel, Sebastien Salas

Open Access Research article

Systems-level effects of ectopic galectin-7 reconstitution in cervical cancer and its microenvironment

Juan Carlos Higareda-Almaraz, Juan S. Ruiz-Moreno, Jana Klimentova, Daniela Barbieri, Raquel Salvador-Gallego, Regina Ly, Ilse A. Valtierra-Gutierrez, Christiane Dinsart, Gabriel A. Rabinovich, Jiri Stulik, Frank Rösl, Bladimiro Rincon-Orozco

Open Access Research article

Clinicopathological implications of Tiam1 overexpression in invasive ductal carcinoma of the breast

Zhenling Li, Qixiang Liu, Junjie Piao, Fenjian Hua, Jing Wang, Guang Jin, Zhenhua Lin, Yan Zhang

Open Access Research article

The insulin-like growth factor system is modulated by exercise in breast cancer survivors: a systematic review and meta-analysis

José Francisco Meneses-Echávez, Emilio González Jiménez, Jacqueline Schmidt Río-Valle, Jorge Enrique Correa-Bautista, Mikel Izquierdo, Robinson Ramírez-Vélez

Open Access Research article

High sensitivity isoelectric focusing to establish a signaling biomarker for the diagnosis of human colorectal cancer

Narendra Padhan, Torbjörn E. M. Nordling, Magnus Sundström, Peter Åkerud, Helgi Birgisson, Peter Nygren, Sven Nelander, Lena Claesson-Welsh

Open Access Case report

Dermatomyositis with anti-TIF-1γ antibodies as a presenting symptom of underlying triple-negative breast cancer: a case report

Ondřej Kubeček, Tomáš Soukup, Adam Paulík, Jindřich Kopecký

Open Access Research article

MicroRNA-21 regulates prostaglandin E2 signaling pathway by targeting 15-hydroxyprostaglandin dehydrogenase in tongue squamous cell carcinoma

Qianting He, Zujian Chen, Qian Dong, Leitao Zhang, Dan Chen, Aditi Patel, Ajay Koya, Xianghong Luan, Robert J. Cabay, Yang Dai, Anxun Wang, Xiaofeng Zhou

Open Access Study protocol

Tailored Beta-catenin mutational approach in extra-abdominal sporadic desmoid tumor patients without therapeutic intervention

Danique L.M. van Broekhoven, Dirk J. Grünhagenl, Thijs van Dalen, Frits van Coevorden, Han J. Bonenkamp, Lukas B. Been, Marc H.A. Bemelmans, Sander D.S. Dijkstra, Chiara Colombo, Alessandro Gronchi, Cornelis Verhoef

Open Access Research article

Worse outcome in breast cancer with higher tumor-infiltrating FOXP3+ Tregs : a systematic review and meta-analysis

Jiafeng Shou, Zhigang Zhang, Yucheng Lai, Zhigang Chen, Jian Huang

Open Access Research article

Changes in the in vitro activity of platinum drugs when administered in two aliquots

Zaynab Al-Eisawi, Philip Beale, Charles Chan, Jun Qing Yu, Nicholas Proschogo, Mark Molloy, Fazlul Huq

Open Access Research article

Survival, recurrence and toxicity of HNSCC in comparison of a radiotherapy combination with cisplatin versus cetuximab: a meta-analysis

Jingwen Huang, Jing Zhang, Changle Shi, Lei Liu, Yuquan Wei

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Belotecan/cisplatin versus etoposide/cisplatin in previously untreated patients with extensive-stage small cell lung carcinoma: a multi-center randomized phase III trial

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Racial differences in six major subtypes of melanoma: descriptive epidemiology

Yu Wang, Yinjun Zhao, Shuangge Ma

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Performance comparison of two commercial human whole-exome capture systems on formalin-fixed paraffin-embedded lung adenocarcinoma samples

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Open Access Case report

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MET and PTEN gene copy numbers and Ki-67 protein expression associate with pathologic complete response in ERBB2-positive breast carcinoma patients treated with neoadjuvant trastuzumab-based therapy

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Open Access Case report

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Open Access Study protocol

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Anna Miquel-Cases, Lotte M. G. Steuten, Lisanne S. Rigter, Wim H. van Harten

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Darby Oldenburg, Yuanbin Ru, Benjamin Weinhaus, Steve Cash, Dan Theodorescu, Sunny Guin

Open Access Research article

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Genome-wide analyses of long noncoding RNA expression profiles correlated with radioresistance in nasopharyngeal carcinoma via next-generation deep sequencing

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Farshid Dayyani, Amado J. Zurita, Graciela M. Nogueras-González, Rebecca Slack, Randall E. Millikan, John C. Araujo, Gary E. Gallick, Christopher J. Logothetis, Paul G. Corn

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Keunhee Oh, Ok-Young Lee, Yeonju Park, Myung Won Seo, Dong-Sup Lee

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Open Access Study protocol

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Prevalence of persistent pain after breast cancer treatment by detection mode among participants in population-based screening programs

Anabel Romero, Isabel Torà-Rocamora, Marisa Baré, Teresa Barata, Laia Domingo, Joana Ferrer, Núria Torà, Mercè Comas, Carmen Merenciano, Francesc Macià, Xavier Castells, Maria Sala

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Kevin Brennan, Christopher Holsinger, Chrysoula Dosiou, John B. Sunwoo, Haruko Akatsu, Robert Haile, Olivier Gevaert

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Open Access Case report

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Primary breast cancer cell culture yields intra-tumor heterogeneous subpopulations expressing exclusive patterns of receptor tyrosine kinases

José Esparza-López, Pier A. Ramos-Elías, Andrea Castro-Sánchez, Leticia Rocha-Zavaleta, Elizabeth Escobar-Arriaga, Alejandro Zentella-Dehesa, Eucario León-Rodríguez, Heriberto Medina-Franco, María de Jesus Ibarra-Sánchez

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Programmed death-ligand 1 (PD-L1) characterization of circulating tumor cells (CTCs) in muscle invasive and metastatic bladder cancer patients

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Polymorphisms in miR-135a-2, miR-219-2 and miR-211 as well as their interaction with cooking oil fume exposure on the risk of lung cancer in Chinese nonsmoking females: a case–control study

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DNA in serum extracellular vesicles is stable under different storage conditions

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Influence of dosing times on cisplatin-induced peripheral neuropathy in rats

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Weight and weight changes throughout life and postmenopausal breast cancer risk: a case-control study in France

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The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways

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Leucine-rich diet alters the 1H-NMR based metabolomic profile without changing the Walker-256 tumour mass in rats

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Ronald E. Myers, Thomas Wolf, Phillip Shwae, Sarah Hegarty, Stephen C. Peiper, Scott A. Waldman

Open Access Study protocol

Effectiveness of community-based football compared to usual care in men with prostate cancer: Protocol for a randomised, controlled, parallel group, multicenter superiority trial (The FC Prostate Community Trial)

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Selective depletion of tumour suppressors Deleted in Colorectal Cancer (DCC) and neogenin by environmental and endogenous serine proteases: linking diet and cancer

Caroline M. Forrest, Kara McNair, Maria C. J. Vincenten, L. Gail Darlington, Trevor W. Stone

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Li-Ting Liu, Qiu-Yan Chen, Lin-Quan Tang, Lu Zhang, Shan-Shan Guo, Ling Guo, Hao-Yuan Mo, Chong Zhao, Xiang Guo, Ming-Yuan Chen, Chao-Nan Qian, Mu-Sheng Zeng, Ming-Huang Hong, Jian-Yong Shao, Ying Sun, Jun Ma, Hai-Qiang Mai

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Open Access Research article

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Open Access Research article

SAKK 24/09: safety and tolerability of bevacizumab plus paclitaxel vs. bevacizumab plus metronomic cyclophosphamide and capecitabine as first-line therapy in patients with HER2-negative advanced stage breast cancer - a multicenter, randomized phase III trial

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Aldehyde dehydrogenase activity plays a Key role in the aggressive phenotype of neuroblastoma

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Prognostic value of computed tomography characteristics for overall survival in patients with maxillary cancer

Ying Yuan, Jingbo Wang, Yingwei Wu, Guojun Li, Xiaofeng Tao

Open Access Research article

MiR-9 is overexpressed in spontaneous canine osteosarcoma and promotes a metastatic phenotype including invasion and migration in osteoblasts and osteosarcoma cell lines

Joelle M. Fenger, Ryan D. Roberts, O. Hans Iwenofu, Misty D. Bear, Xiaoli Zhang, Jason I. Couto, Jaime F. Modiano, William C. Kisseberth, Cheryl A. London

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Open Access Case report

Complete pathological response following neoadjuvant FOLFIRINOX in borderline resectable pancreatic cancer - a case report and review

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Elisabeth Peters, Laura Mendoza Schulz, Monika Reuss-Borst

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Claudin-4 activity in ovarian tumor cell apoptosis resistance and migration

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Molecular profile of 5-fluorouracil pathway genes in colorectal carcinoma

T. Kunicka, P. Prochazka, I. Krus, P. Bendova, M. Protivova, S. Susova, V. Hlavac, V. Liska, P. Novak, M. Schneiderova, P. Pitule, J. Bruha, O. Vycital, P. Vodicka, P. Soucek

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Time trend analysis of primary liver cancer incidence in Sihui county of Guangdong Province, China (1987–2011)

Wenyi Liu, Qing Liu, Qihong Huang, Yuqiang Lu, Shanghang Xie, Aihua Lin, Sumei Cao

Open Access Research article

CT guided cryoablation for locally recurrent or metastatic bone and soft tissue tumor: initial experience

Michiro Susa, Kazutaka Kikuta, Robert Nakayama, Kazumasa Nishimoto, Keisuke Horiuchi, Sota Oguro, Masanori Inoue, Hideki Yashiro, Seishi Nakatsuka, Masaya Nakamura, Morio Matsumoto, Kazuhiro Chiba, Hideo Morioka

Open Access Research article

Incidence and Survival of urothelial carcinoma of the urinary bladder in Norway 1981-2014

B. K. Andreassen, B. Aagnes, R. Gislefoss, M. Andreassen, R. Wahlqvist

Open Access Research article

Interplay of N-Cadherin and matrix metalloproteinase 9 enhances human nasopharyngeal carcinoma cell invasion

Chih-Chin Hsu, Shiang-Fu Huang, Jong-Shyan Wang, Wing-Keung Chu, Ju-En Nien, Wei-Shan Chen, Shu-Er Chow

Open Access Case report

Disseminated carcinomatosis of the bone marrow from pancreatic cancer: a case report

Hiroki Namikawa, Yasuhiko Takemoto, Ayako Makuuchi, Masanori Kobayashi, Shigeki Kinuhata, Mina Morimura, Takashi Ikebe, Hiromu Tanaka, Taichi Shuto

Open Access Study protocol

The REFRACT-LYMA cohort study: a French observational prospective cohort study of patients with mantle cell lymphoma

Matthieu Hanf, David Chiron, Sophie de Visme, Cyrille Touzeau, Hervé Maisonneuve, Henry Jardel, Catherine Pellat-Deceunynck, Martine Amiot, Steven le Gouill

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Projecting productivity losses for cancer-related mortality 2011 – 2030

Alison Pearce, Cathy Bradley, Paul Hanly, Ciaran O’Neill, Audrey Alforque Thomas, Michal Molcho, Linda Sharp

Open Access Research article

A diagnostic marker for superficial urothelial bladder carcinoma: lack of nuclear ATBF1 (ZFHX3) by immunohistochemistry suggests malignant progression

Makoto Kawaguchi, Noboru Hara, Vladimir Bilim, Hiroshi Koike, Mituko Suzuki, Tae-Sun Kim, Nan Gao, Yu Dong, Sheng Zhang, Yuji Fujinawa, Osamu Yamamoto, Hiromi Ito, Yoshihiko Tomita, Yuchi Naruse, Akira Sakamaki, Yoko Ishii, Koichi Tsuneyama, Masaaki Inoue, Johbu Itoh, Masanori Yasuda, Nobuo Sakata, Cha-Gyun Jung, Satoshi Kanazawa, Hiroyasu Akatsu, Hiroshi Minato, Takayuki Nojima, Kiyofumi Asai, Yutaka Miura

Open Access Research article

miR-10b exerts oncogenic activity in human hepatocellular carcinoma cells by targeting expression of CUB and sushi multiple domains 1 (CSMD1)

Qiao Zhu, Li Gong, Jun Wang, Qian Tu, Li Yao, Jia-Rui Zhang, Xiu-Juan Han, Shao-Jun Zhu, Shu-Mei Wang, Yan-Hong Li, Wei Zhang

Open Access Research article

A novel variant on chromosome 6p21.1 is associated with the risk of developing colorectal cancer: a two-stage case-control study in Han Chinese

Chunxiao Xu, Dan Zhou, Feixia Pan, Yi Liu, Dandan zhang, Aifen Lin, Xiaoping Miao, Yaqin Ni, Duo Lv, Shuai Zhang, Xiaobo Li, Yimin Zhu, Maode Lai

Open Access Research article

Phase-specific and lifetime costs of cancer care in Ontario, Canada

Claire de Oliveira, Reka Pataky, Karen E. Bremner, Jagadish Rangrej, Kelvin K. W. Chan, Winson Y. Cheung, Jeffrey S. Hoch, Stuart Peacock, Murray D. Krahn

Open Access Research article

Hepatocellular carcinoma-targeted drug discovery through image-based phenotypic screening in co-cultures of HCC cells with hepatocytes

Jae-Woo Jang, Yeonhwa Song, Kang Mo Kim, Jin-Sun Kim, Eun Kyung Choi, Joon Kim, Haengran Seo

Open Access Research article

Identification of BRCA1-like triple-negative breast cancers by quantitative multiplex-ligation-dependent probe amplification (MLPA) analysis of BRCA1-associated chromosomal regions: a validation study

Eva Gross, Harm van Tinteren, Zhou Li, Sandra Raab, Christina Meul, Stefanie Avril, Nadja Laddach, Michaela Aubele, Corinna Propping, Apostolos Gkazepis, Manfred Schmitt, Alfons Meindl, Petra M. Nederlof, Marion Kiechle, Esther H. Lips

Open Access Study protocol

Development of OXY111A, a novel hypoxia-modifier as a potential antitumor agent in patients with hepato-pancreato-biliary neoplasms - Protocol of a first Ib/IIa clinical trial

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Open Access Research article

Inhibition of eEF-2 kinase sensitizes human nasopharyngeal carcinoma cells to lapatinib-induced apoptosis through the Src and Erk pathways

Lin Liu, PeiYu Huang, ZhiHui Wang, Nan Chen, Con Tang, Zhong Lin, PeiJian Peng

Open Access Research article

Ridaforolimus (MK-8669) synergizes with Dalotuzumab (MK-0646) in hormone-sensitive breast cancer

Marc A. Becker, Xiaonan Hou, Piyawan Tienchaianada, Brian B. Haines, Sean C. Harrington, S. John Weroha, Sriram Sathyanarayanan, Paul Haluska

Open Access Research article

KLHL21, a novel gene that contributes to the progression of hepatocellular carcinoma

Lei Shi, Wenfa Zhang, Fagui Zou, Lihua Mei, Gang Wu, Yong Teng

Open Access Study protocol

INNOVATE: A prospective cohort study combining serum and urinary biomarkers with novel diffusion-weighted magnetic resonance imaging for the prediction and characterization of prostate cancer

Edward Johnston, Hayley Pye, Elisenda Bonet-Carne, Eleftheria Panagiotaki, Dominic Patel, Myria Galazi, Susan Heavey, Lina Carmona, Alexander Freeman, Giorgia Trevisan, Clare Allen, Alexander Kirkham, Keith Burling, Nicola Stevens, David Hawkes, Mark Emberton, Caroline Moore, Hashim U Ahmed, David Atkinson, Manuel Rodriguez-Justo, Tony Ng, Daniel Alexander, Hayley Whitaker, Shonit Punwani

Open Access Research article

Efficacy and safety profile of nab-paclitaxel plus gemcitabine in patients with metastatic pancreatic cancer treated to disease progression: a subanalysis from a phase 3 trial (MPACT)

Arndt Vogel, Josefine Römmler-Zehrer, Jack Shiansong Li, Desmond McGovern, Alfredo Romano, Michael Stahl

Open Access Research article

Selumetinib suppresses cell proliferation, migration and trigger apoptosis, G1 arrest in triple-negative breast cancer cells

Yan Zhou, Shuchen Lin, Kuo-Fu Tseng, Kun Han, Yaling Wang, Zhi-hua Gan, Da-liu Min, Hai-yan Hu

Open Access Research article

Cervical and breast cancer screening uptake among women with serious mental illness: a data linkage study

Charlotte Woodhead, Ruth Cunningham, Mark Ashworth, Elizabeth Barley, Robert J. Stewart, Max J. Henderson

Open Access Research article

Validation of the CancerMath prognostic tool for breast cancer in Southeast Asia

Hui Miao, Mikael Hartman, Helena M. Verkooijen, Nur Aishah Taib, Hoong-Seam Wong, Shridevi Subramaniam, Cheng-Har Yip, Ern-Yu Tan, Patrick Chan, Soo-Chin Lee, Nirmala Bhoo-Pathy

Open Access Research article

Reduced mRNA expression levels of NFE2L2 are associated with poor outcome in breast cancer patients

Barbara Wolf, Georg Goebel, Hubert Hackl, Heidi Fiegl

Open Access Research article

In vitro and in vivo activity of miR-92a–Locked Nucleic Acid (LNA)–Inhibitor against endometrial cancer

Anna Torres, Joanna Kozak, Agnieszka Korolczuk, Paulina Wdowiak, Ewa Domańska-Glonek, Ryszard Maciejewski, Kamil Torres

Open Access Research article

Additive value of pre-operative and one-month post-operative lymphocyte count for death-risk stratification in patients with resectable pancreatic cancer: a multicentric study

Christelle d’Engremont, Dewi Vernerey, Anne-Laure Pointet, Gaël Simone, Francine Fein, Bruno Heyd, Stéphane Koch, Lucine Vuitton, Stefano Kim, Marine Jary, Najib Lamfichek, Celia Turco, Zaher Lakkis, Anne Berger, Franck Bonnetain, Julien Taieb, Philippe Bachellier, Christophe Borg

Open Access Research article

Induction of autophagy by ARHI (DIRAS3) alters fundamental metabolic pathways in ovarian cancer models

Argentina Ornelas, Christopher R. McCullough, Zhen Lu, Niki M. Zacharias, Lindsay E. Kelderhouse, Joshua Gray, Hailing Yang, Brian J. Engel, Yan Wang, Weiqun Mao, Margie N. Sutton, Pratip K. Bhattacharya, Robert C. Bast Jr., Steven W. Millward

Open Access Research article

RAS testing practices and RAS mutation prevalence among patients with metastatic colorectal cancer: results from a Europe-wide survey of pathology centres

Annemarie Boleij, Véronique Tack, Aliki Taylor, George Kafatos, Sophie Jenkins-Anderson, Lien Tembuyser, Els Dequeker, J. Han van Krieken

Open Access Research article

miR-124-3p functions as a tumor suppressor in breast cancer by targeting CBL

Yanbo Wang, Luxiao Chen, Zhenyu Wu, Minghai Wang, Fangfang Jin, Nan Wang, Xiuting Hu, Zhengya Liu, Chen-Yu Zhang, Ke Zen, Jiangning Chen, Hongwei Liang, Yujing Zhang, Xi Chen

Open Access Case report

Invasive myoepithelial carcinoma ex pleomorphic adenoma of the major salivary gland: two case reports

Takahiro Wakasaki, Marie Kubota, Yutaka Nakashima, Eri Tomonobe, Takenao Mihara, Junichi Fukushima

Open Access Research article

Epidemiological study of HER-2 mutations among EGFR wild-type lung adenocarcinoma patients in China

Xuefei Li, Chao Zhao, Chunxia Su, Shengxiang Ren, Xiaoxia Chen, Caicun Zhou

Open Access Research article

Subcellular localisation of pMEK has a different prognosis in locally advanced head and neck cancer treated with concomitant radiochemotherapy

J. Gomez-Millan, B. Pajares, L. Perez-Villa, A. Carnero, M. Alvarez, V. De Luque, F. Rivas, J. M. Trigo, M. D. Toledo, E. Alba, J. A. Medina

Open Access Study protocol

Living well after breast cancer randomized controlled trial protocol: evaluating a telephone-delivered weight loss intervention versus usual care in women following treatment for breast cancer

Marina M. Reeves, Caroline O. Terranova, Jane M. Erickson, Jennifer R. Job, Denise S. K. Brookes, Nicole McCarthy, Ingrid J. Hickman, Sheleigh P. Lawler, Brianna S. Fjeldsoe, Genevieve N. Healy, Elisabeth A. H. Winkler, Monika Janda, J. Lennert Veerman, Robert S. Ware, Johannes B. Prins, Theo Vos, Wendy Demark-Wahnefried, Elizabeth G. Eakin

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Enhanced therapeutic efficacy of LHRHa-targeted brucea javanica oil liposomes for ovarian cancer

Hongxia Ye, Xiaojuan Liu, Jiangchuan Sun, Shenyin Zhu, Yi Zhu, Shufang Chang

Open Access Research article

Prognostic contribution of mammographic breast density and HER2 overexpression to the Nottingham Prognostic Index in patients with invasive breast cancer

Amro Masarwah, Päivi Auvinen, Mazen Sudah, Vaiva Dabravolskaite, Otso Arponen, Anna Sutela, Sanna Oikari, Veli-Matti Kosma, Ritva Vanninen

Open Access Research article

Long-term survival analysis in combined transarterial embolization and stereotactic body radiation therapy versus stereotactic body radiation monotherapy for unresectable hepatocellular carcinoma >5 cm

Ting-Shi Su, Huan-Zhen Lu, Tao Cheng, Ying Zhou, Yong Huang, Ying-Chuan Gao, Min-Yang Tang, Hua-Yan Jiang, Zu-Ping Lian, En-Cun Hou, Ping Liang

Open Access Study protocol

Study protocol of the CHOiCE trial: a three-armed, randomized, controlled trial of home-based HPV self-sampling for non-participants in an organized cervical cancer screening program

Mette Tranberg, Bodil Hammer Bech, Jan Blaakær, Jørgen Skov Jensen, Hans Svanholm, Berit Andersen

Open Access Research article

Increased serum amyloid A as potential diagnostic marker for lung cancer: a meta-analysis based on nine studies

Rong Biaoxue, Liu Hua, Gao Wenlong, Yang Shuanying

Open Access Study protocol

A prospective multicenter study on bladder cancer: the COBLAnCE cohort

Simone Benhamou, Julia Bonastre, Karine Groussard, François Radvanyi, Yves Allory, Thierry Lebret

Open Access Study protocol

Web-based stress management for newly diagnosed cancer patients (STREAM-1): a randomized, wait-list controlled intervention study

Astrid Grossert, Corinne Urech, Judith Alder, Jens Gaab, Thomas Berger, Viviane Hess

Open Access Research article

Risk of uterine, ovarian and breast cancer following pelvic inflammatory disease: a nationwide population-based retrospective cohort study

Cheng-Che Shen, Li-Yu Hu, Albert C. Yang, Yung-Yen Chiang, Jeng-Hsiu Hung, Shih-Jen Tsai

Open Access Research article

The differential role of HTRA1 in HPV-positive and HPV-negative cervical cell line proliferation

Bruna Stuqui, André Luis Giacometti Conceição, Lara Termini, Laura Sichero, Luisa Lina Villa, Paula Rahal, Marília de Freitas Calmon

Open Access Research article

The expression pattern of matrix-producing tumor stroma is of prognostic importance in breast cancer

Sofia Winslow, Kajsa Ericson Lindquist, Anders Edsjö, Christer Larsson

Open Access Case report

Planning TTFields treatment using the NovoTAL system-clinical case series beyond the use of MRI contrast enhancement

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A consultation training program for physicians for communication about complementary medicine with breast cancer patients: a prospective, multi-center, cluster-randomized, mixed-method pilot study

Susanne Blödt, Nadine Mittring, Lena Schützler, Felix Fischer, Christine Holmberg, Markus Horneber, Adele Stapf, Claudia M. Witt

Open Access Research article

Pancreatic resection for intraductal papillary mucinous neoplasm– a thirteen-year single center experience

Katharina Marsoner, Johannes Haybaeck, Dora Csengeri, James Elvis Waha, Jakob Schagerl, Rainer Langeder, Hans Joerg Mischinger, Peter Kornprat

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Is alcohol consumption a risk factor for prostate cancer? A systematic review and meta–analysis

Jinhui Zhao, Tim Stockwell, Audra Roemer, Tanya Chikritzhs

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LPA receptor 1 mediates LPA-induced ovarian cancer metastasis: an in vitro and in vivo study

Xuechen Yu, Yuanzhen Zhang, Huijun Chen

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Estimating long-term clinical effectiveness and cost-effectiveness of HPV 16/18 vaccine in China

Qian Zhang, Yi-Jun Liu, Shang-Ying Hu, Fang-Hui Zhao

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Temporal trends in the risk of developing multiple primary cancers: a systematic review

Yuanzi Ye, Amanda L. Neil, Karen E. Wills, Alison J. Venn

Open Access Research article

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Francesca Aredia, Sebastian Czaplinski, Simone Fulda, A. Ivana Scovassi

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Assessment of human papillomavirus E6/E7 oncogene expression as cervical disease biomarker

Nerea Fontecha, Miren Basaras, Silvia Hernáez, Daniel Andía, Ramón Cisterna

Open Access Research article

Identification of microRNA profile specific to cancer stem-like cells directly isolated from human larynx cancer specimens

Omer Faruk Karatas, Ilknur Suer, Betul Yuceturk, Mehmet Yilmaz, Buge Oz, Gulgun Guven, Harun Cansiz, Chad J. Creighton, Michael Ittmann, Mustafa Ozen

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Aberrant activation of Notch signaling in extrahepatic cholangiocarcinoma: clinicopathological features and therapeutic potential for cancer stem cell-like properties

Shuichi Aoki, Masamichi Mizuma, Yayoi Takahashi, Yoichi Haji, Ryo Okada, Tomoya Abe, Hideaki Karasawa, Keiichi Tamai, Takaho Okada, Takanori Morikawa, Hiroki Hayashi, Kei Nakagawa, Fuyuhiko Motoi, Takeshi Naitoh, Yu Katayose, Michiaki Unno

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Frequency of Her2/neu expression in colorectal adenocarcinoma: a study from developing South Asian Country

Asma Shabbir, Talat Mirza, Abdullah Bin Khalid, Muhammad Asif Qureshi, Sadaf Ahmed Asim

Open Access Study protocol

Single administration of Selective Internal Radiation Therapy versus continuous treatment with sorafeNIB in locally advanced hepatocellular carcinoma (SIRveNIB): study protocol for a phase iii randomized controlled trial

Mihir Gandhi, Su Pin Choo, Choon Hua Thng, Say Beng Tan, Albert Su Chong Low, Peng Chung Cheow, Anthony Soon Whatt Goh, Kiang Hiong Tay, Richard Hoau Gong Lo, Brian Kim Poh Goh, Jen San Wong, David Chee Eng Ng, Khee Chee Soo, Wei Ming Liew, Pierce K. H. Chow

Open Access Research article

Vorinostat enhances the cisplatin-mediated anticancer effects in small cell lung cancer cells

Chun-Hao Pan, Ying-Fang Chang, Ming-Shuo Lee, B-Chen Wen, Jen-Chung Ko, Sheng-Kai Liang, Mei-Chih Liang

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Management of controversial gastroenteropancreatic neuroendocrine tumour clinical situations with somatostatin analogues: results of a Delphi questionnaire panel from the NETPraxis program

Isabel Sevilla, Ángel Segura, Jaume Capdevila, Carlos López, Rocío García-Carbonero, Enrique Grande

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Comparison of the pharmacokinetics between L-BPA and L-FBPA using the same administration dose and protocol: a validation study for the theranostic approach using [18F]-L-FBPA positron emission tomography in boron neutron capture therapy

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Open Access Research article

Antineoplastic treatment effect on bone mineral density in Mexican breast cancer patients

Karina Monroy-Cisneros, Julián Esparza-Romero, Mauro E. Valencia, Alfonso G. Guevara-Torres, Rosa O. Méndez-Estrada, Iván Anduro-Corona, Humberto Astiazarán-García

Open Access Research article

Chronic hepatitis infection is associated with extrahepatic cancer development: a nationwide population-based study in Taiwan

Abram Bunya Kamiza, Fu-Hsiung Su, Wen-Chang Wang, Fung-Chang Sung, Shih-Ni Chang, Chih-Ching Yeh

Open Access Case report

A case series of intestinal adenomatous polyposis of unidentified etiology; a late effect of irradiation?

Lisanne Sara Rigter, Frank G. J. Kallenberg, Barbara Bastiaansen, Theo A. M. van Os, Floor E. van Leeuwen, Monique Esther van Leerdam, Evelien Dekker

Open Access Research article

Let-7 inhibits self-renewal of hepatocellular cancer stem-like cells through regulating the epithelial-mesenchymal transition and the Wnt signaling pathway

Bin Jin, Wei Wang, Xiang-xin Meng, Gang Du, Jia Li, Shi-zhe Zhang, Bing-hai Zhou, Zhi-hao Fu

Open Access Research article

Frequency of EGFR T790M mutation and multimutational profiles of rebiopsy samples from non-small cell lung cancer developing acquired resistance to EGFR tyrosine kinase inhibitors in Japanese patients

Ryo Ko, Hirotsugu Kenmotsu, Masakuni Serizawa, Yasuhiro Koh, Kazushige Wakuda, Akira Ono, Tetsuhiko Taira, Tateaki Naito, Haruyasu Murakami, Mitsuhiro Isaka, Masahiro Endo, Takashi Nakajima, Yasuhisa Ohde, Nobuyuki Yamamoto, Kazuhisa Takahashi, Toshiaki Takahashi

Open Access Research article

Early evaluation of irradiated parotid glands with intravoxel incoherent motion MR imaging: correlation with dynamic contrast-enhanced MR imaging

Nan Zhou, Chen Chu, Xin Dou, Ming Li, Song Liu, Lijing Zhu, Baorui Liu, Tingting Guo, Weibo Chen, Jian He, Jing Yan, Zhengyang Zhou, Xiaofeng Yang, Tian Liu

Open Access Research article

Prevalence and distribution of cervical high-risk human papillomavirus and cytological abnormalities in women living with HIV in Denmark – the SHADE

Kristina Thorsteinsson, Merete Storgaard, Terese L. Katzenstein, Steen Ladelund, Frederikke Falkencrone Rønsholt, Isik Somuncu Johansen, Gitte Pedersen, Lailoma Hashemi, Lars Nørregård Nielsen, Lisbeth Nilas, Niels Obel, Jesper Bonde, Anne-Mette Lebech

Open Access Research article

Treatment of a chemoresistant neuroblastoma cell line with the antimalarial ozonide OZ513

Don W. Coulter, Timothy R. McGuire, John G. Sharp, Erin M. McIntyre, Yuxiang Dong, Xiaofang Wang, Shawn Gray, Gracey R. Alexander, Nagendra K. Chatuverdi, Shantaram S. Joshi, Xiaoyu Chen, Jonathan L. Vennerstrom

Open Access Research article

Impact of clinical parameters and systemic inflammatory status on epidermal growth factor receptor-mutant non-small cell lung cancer patients readministration with epidermal growth factor receptor tyrosine kinase inhibitors

Yu-Mu Chen, Chien-Hao Lai, Kun-Ming Rau, Cheng-Hua Huang, Huang-Chih Chang, Tung-Ying Chao, Chia-Cheng Tseng, Wen-Feng Fang, Yu-Hsiu Chung, Yi-Hsi Wang, Mao-Chang Su, Kuo-Tung Huang, Shih-Feng Liu, Hung-Chen Chen, Ya-Chun Chang, Yu-Ping Chang, Chin-Chou Wang, Meng-Chih Lin

Open Access Research article

Secreted Frizzled-Related Protein 2 (sFRP2) promotes osteosarcoma invasion and metastatic potential

Piti Techavichit, Yang Gao, Lyazat Kurenbekova, Ryan Shuck, Lawrence A. Donehower, Jason T. Yustein

Open Access Research article

Binding of galectin-1 to breast cancer cells MCF7 induces apoptosis and inhibition of proliferation in vitro in a 2D- and 3D- cell culture model

Pamina Geiger, Barbara Mayer, Irmi Wiest, Sandra Schulze, Udo Jeschke, Tobias Weissenbacher

Open Access Research article

Growth hormone is increased in the lungs and enhances experimental lung metastasis of melanoma in DJ-1 KO mice

Chia-Hung Chien, Ming-Jen Lee, Houng-Chi Liou, Horng-Huei Liou, Wen-Mei Fu

Open Access Research article

Improved nutrition in adolescents and young adults after childhood cancer - INAYA study

J. Quidde, J. von Grundherr, B. Koch, C. Bokemeyer, G. Escherich, L. Valentini, D. Buchholz, G. Schilling, A. Stein

Open Access Research article

Esophageal squamous cell carcinoma invasion is inhibited by Activin A in ACVRIB-positive cells

Holli A. Loomans, Shanna A. Arnold, Laura L. Quast, Claudia D. Andl

Open Access Research article

Investigation of optical coherence micro-elastography as a method to visualize micro-architecture in human axillary lymph nodes

Kelsey M. Kennedy, Lixin Chin, Philip Wijesinghe, Robert A. McLaughlin, Bruce Latham, David D. Sampson, Christobel M. Saunders, Brendan F. Kennedy

Open Access Research article

Metastasis-associated in colon cancer-1 and aldehyde dehydrogenase 1 are metastatic and prognostic biomarker for non-small cell lung cancer

Lei Zhou, Lan Yu, Bo Zhu, Shiwu Wu, Wenqing Song, Xiaomeng Gong, Danna Wang

Open Access Research article

Longitudinal alterations in health-related quality of life and its impact on the clinical course of patients with advanced hepatocellular carcinoma receiving sorafenib treatment

Masako Shomura, Tatehiro Kagawa, Haruka Okabe, Koichi Shiraishi, Shunji Hirose, Yoshitaka Arase, Kota Tsuruya, Sachiko Takahira, Tetsuya Mine

Open Access Research article

Activins and their related proteins in colon carcinogenesis: insights from early and advanced azoxymethane rat models of colon cancer

Bassem Refaat, Adel Galal El-Shemi, Amr Mohamed Mohamed, Osama Adnan Kensara, Jawwad Ahmad, Shakir Idris

Open Access Research article

High-mobility group protein box1 expression correlates with peritumoral macrophage infiltration and unfavorable prognosis in patients with hepatocellular carcinoma and cirrhosis

Qiang-Bo Zhang, Qing-an Jia, Hong Wang, Chun-Xiao Hu, Dong Sun, Run-De Jiang, Zong-Li Zhang

Open Access Research article

Screening and characterization of novel specific peptides targeting MDA-MB-231 claudin-low breast carcinoma by computer-aided phage display methodologies

Franklin L. Nobrega, Débora Ferreira, Ivone M. Martins, Maria Suarez-Diez, Joana Azeredo, Leon D. Kluskens, Lígia R. Rodrigues

Open Access Research article

Synthesis and bio-molecular study of (+)-N-Acetyl-α-amino acid dehydroabietylamine derivative for the selective therapy of hepatocellular carcinoma

Muhammad Ayaz Mustufa, Cigdem Ozen, Imran Ali Hashmi, Afshan Aslam, Jameel Ahmed Baig, Gokhan Yildiz, Shoaib Muhammad, Imam Bakhsh Solangi, Naim ul Hasan Naqvi, Mehmet Ozturk, Firdous Imran Ali

Open Access Research article

EpCAM as multi-tumour target for near-infrared fluorescence guided surgery

P. B. A. A. van Driel, M. C. Boonstra, H. A. J. M. Prevoo, M. van de Giessen, T. J. A. Snoeks, Q. R. J. G. Tummers, S. Keereweer, R. A. Cordfunke, A. Fish, J. D. H. van Eendenburg, B. P. F. Lelieveldt, J. Dijkstra, C. J. H. van de Velde, P. J. K. Kuppen, A. L. Vahrmeijer, C. W. G. M. Löwik, C. F. M. Sier

Open Access Research article

Global DNA methylation profiling uncovers distinct methylation patterns of protocadherin alpha4 in metastatic and non-metastatic rhabdomyosarcoma

L. Tombolan, E. Poli, P. Martini, A. Zin, C. Millino, B. Pacchioni, B. Celegato, G. Bisogno, C. Romualdi, A. Rosolen, G. Lanfranchi

Open Access Research article

miR-199a-5p confers tumor-suppressive role in triple-negative breast cancer

Jiawei Chen, Vivian Y. Shin, Man T. Siu, John C. W. Ho, Isabella Cheuk, Ava Kwong

Open Access Research article

Clinical outcomes of patients with gastrointestinal stromal tumor in phase I clinical trials

Yoshiaki Nagatani, Kohei Shitara, Hideaki Bando, Yasutoshi Kuboki, Wataru Okamoto, Takashi Kojima, Takayuki Yoshino, Toshirou Nishida, Atushi Ohtsu, Toshihiko Doi

Open Access Research article

The prognostic value of serum CA 19-9 for patients with advanced lung adenocarcinoma

Yuki Sato, Daichi Fujimoto, Keiichiro Uehara, Ryoko Shimizu, Jiro Ito, Mariko Kogo, Shunsuke Teraoka, Ryoji Kato, Kazuma Nagata, Atsushi Nakagawa, Kojiro Otsuka, Hiroshi Hamakawa, Yutaka Takahashi, Yukihiro Imai, Keisuke Tomii

Open Access Research article

Autophagy is associated with chemoresistance in neuroblastoma

Assila Belounis, Carine Nyalendo, Roxane Le Gall, Tina V. Imbriglio, Mohamed Mahma, Pierre Teira, Mona Beaunoyer, Sonia Cournoyer, Elie Haddad, Gilles Vassal, Hervé Sartelet

Open Access Research article

Overexpression of UNC5B in bladder cancer cells inhibits proliferation and reduces the volume of transplantation tumors in nude mice

Chuize Kong, Bo Zhan, Chiyuan Piao, Zhe Zhang, Yuyan Zhu, Qingchang Li

Open Access Research article

Long-lasting reduction in clonogenic potential of colorectal cancer cells by sequential treatments with 5-azanucleosides and topoisomerase inhibitors

Alicja Pawlak, Ewa Ziolo, Anna Fiedorowicz, Klaudyna Fidyt, Leon Strzadala, Wojciech Kalas

Open Access Research article

MPC1 and MPC2 expressions are associated with favorable clinical outcomes in prostate cancer

Xiaoli Li, Yasai Ji, Gaoyang Han, Xiaoran Li, Zhirui Fan, Yaqing Li, Yali Zhong, Jing Cao, Jing Zhao, Mingzhi Zhang, Jianguo Wen, Mariusz Adam Goscinski, Jahn M. Nesland, Zhenhe Suo

Open Access Case report

NUT midline carcinoma mimicking a germ cell tumor: a case report

Yohei Harada, Takafumi Koyama, Kengo Takeuchi, Kazufusa Shoji, Kazuei Hoshi, Yu Oyama

Open Access Research article

Salinomycin inhibits metastatic colorectal cancer growth and interferes with Wnt/β-catenin signaling in CD133+ human colorectal cancer cells

Johannes Klose, Jana Eissele, Claudia Volz, Steffen Schmitt, Alina Ritter, Shen Ying, Thomas Schmidt, Ulrike Heger, Martin Schneider, Alexis Ulrich

Open Access Research article

Expression of Par3 polarity protein correlates with poor prognosis in ovarian cancer

Hiroe Nakamura, Kazunori Nagasaka, Kei Kawana, Ayumi Taguchi, Yuriko Uehara, Mitsuyo Yoshida, Masakazu Sato, Haruka Nishida, Asaha Fujimoto, Tomoko Inoue, Katsuyuki Adachi, Takeshi Nagamatsu, Takahide Arimoto, Katsutoshi Oda, Yutaka Osuga, Tomoyuki Fujii

Open Access Research article

Prognostic value of CD66b positive tumor-infiltrating neutrophils in testicular germ cell tumor

Yuta Yamada, Tohru Nakagawa, Toru Sugihara, Takamasa Horiuchi, Uran Yoshizaki, Tetsuya Fujimura, Hiroshi Fukuhara, Tomohiko Urano, Kenichi Takayama, Satoshi Inoue, Haruki Kume, Yukio Homma

Open Access Research article

Tanshinone IIA combined with adriamycin inhibited malignant biological behaviors of NSCLC A549 cell line in a synergistic way

Jun Xie, Jia-Hui Liu, Heng Liu, Xiao-Zhong Liao, Yuling Chen, Mei-Gui Lin, Yue-Yu Gu, Tao-Li Liu, Dong-Mei Wang, Hui Ge, Sui-Lin Mo

Open Access Research article

Association of nutritional status-related indices and chemotherapy-induced adverse events in gastric cancer patients

Seung Hee Seo, Sung-Eun Kim, Yoon-Koo Kang, Baek-Yeol Ryoo, Min-Hee Ryu, Jae Ho Jeong, Shin Sook Kang, Mihi Yang, Jung Eun Lee, Mi-Kyung Sung

Open Access Research article

In silico SNP analysis of the breast cancer antigen NY-BR-1

Zeynep Kosaloglu, Julia Bitzer, Niels Halama, Zhiqin Huang, Marc Zapatka, Andreas Schneeweiss, Dirk Jäger, Inka Zörnig

Open Access Research article

Hypoxic resistance of KRAS mutant tumor cells to 3-Bromopyruvate is counteracted by Prima-1 and reversed by N-acetylcysteine

Andrea Orue, Valery Chavez, Mary Strasberg-Rieber, Manuel Rieber

Open Access Research article

Keratin 19 as a key molecule in progression of human hepatocellular carcinomas through invasion and angiogenesis

Masato Takano, Keiji Shimada, Tomomi Fujii, Kohei Morita, Maiko Takeda, Yoshiyuki Nakajima, Akitaka Nonomura, Noboru Konishi, Chiho Obayashi

Open Access Research article

ANLN is a prognostic biomarker independent of Ki-67 and essential for cell cycle progression in primary breast cancer

Kristina Magnusson, Gabriela Gremel, Lisa Rydén, Victor Pontén, Mathias Uhlén, Anna Dimberg, Karin Jirström, Fredrik Pontén

Open Access Research article

Is immunohistochemistry of BRAF V600E useful as a screening tool and during progression disease of melanoma patients?

Laura Schirosi, Sabino Strippoli, Francesca Gaudio, Giusi Graziano, Ondina Popescu, Michele Guida, Giovanni Simone, Anita Mangia

Open Access Research article

A phase I dose-escalation study of PEP02 (irinotecan liposome injection) in combination with 5-fluorouracil and leucovorin in advanced solid tumors

Nai-Jung Chiang, Tsu-Yi Chao, Ruey-Kuen Hsieh, Cheng-Hsu Wang, Yi-Wen Wang, C. Grace Yeh, Li-Tzong Chen

Open Access Research article

Might radiation therapy in addition to chemotherapy improve overall survival of patients with non-oligometastatic Stage IV non-small cell lung cancer?: Secondary analysis of two prospective studies

ShengFa Su, YinXiang Hu, WeiWei Ouyang, Zhu Ma, QingSong Li, HuiQin Li, Yu Wang, XiaoHu Wang, Tao Li, JianCheng Li, Ming Chen, You Lu, YuJu Bai, ZhiXu He, Bing Lu

Open Access Study protocol

Comparing conVEntional RadioTherapy with stereotactIC body radiotherapy in patients with spinAL metastases: study protocol for an randomized controlled trial following the cohort multiple randomized controlled trial design

Joanne M. van der Velden, Helena M. Verkooijen, Enrica Seravalli, Jochem Hes, A. Sophie Gerlich, Nicolien Kasperts, Wietse S. C. Eppinga, Jorrit-Jan Verlaan, Marco van Vulpen

Open Access Research article

The prognostic significance of human epidermal growth factor receptor family protein expression in operable pancreatic cancer

Qin Li, Lei Zhang, XiuHong Li, Han Yan, Liuting Yang, Yingying Li, Teng Li, Jing Wang, Bangwei Cao

Open Access Research Article

Conservation of immune gene signatures in solid tumors and prognostic implications

Julia Chifman, Ashok Pullikuth, Jeff W. Chou, Davide Bedognetti, Lance D. Miller

Open Access Research article

Incidence and risk of hypertension in patients newly treated for multiple myeloma: a retrospective cohort study

Ajai Chari, Khalid Mezzi, Shao Zhu, Winifred Werther, Diana Felici, Alexander R. Lyon

Open Access Research article

A systematic comparison of copy number alterations in four types of female cancer

Fatemeh Kaveh, Lars O. Baumbusch, Daniel Nebdal, Anne-Lise Børresen-Dale, Ole Christian Lingjærde, Hege Edvardsen, Vessela N. Kristensen, Hiroko K. Solvang

Open Access Research article

Phase I study of low-dose metronomic temozolomide for recurrent malignant gliomas

Eric T. Wong, Joshua Timmons, Amy Callahan, Lauren O’Loughlin, Bridget Giarusso, David C. Alsop

Open Access Research article

Increased Wnt5a in squamous cell lung carcinoma inhibits endothelial cell motility

J. Rapp, E. Kiss, M. Meggyes, E. Szabo-Meleg, D. Feller, G. Smuk, T. Laszlo, V. Sarosi, T. F. Molnar, K. Kvell, J. E. Pongracz

Open Access Erratum

Erratum to: Prognostic impact of CXCL16 and CXCR6 in non-small cell lung cancer: combined high CXCL16 expression in tumor stroma and cancer cells yields improved survival

Sigurd M. Hald, Yury Kiselev, Samer Al-Saad, Elin Richardsen, Charles Johannessen, Marte Eilertsen, Thomas K. Kilvaer, Khalid Al-Shibli, Sigve Andersen, Lill-Tove Busund, Roy M. Bremnes, Tom Donnem

Open Access Research article

Anti-LRP/LR-specific antibody IgG1-iS18 impedes adhesion and invasion of pancreatic cancer and neuroblastoma cells

Thalia M. Rebelo, Carryn J. Chetty, Eloise Ferreira, Stefan F. T. Weiss

Open Access Study protocol

Phase II clinical study of valproic acid plus cisplatin and cetuximab in recurrent and/or metastatic squamous cell carcinoma of Head and Neck-V-CHANCE trial

Francesco Caponigro, Elena Di Gennaro, Franco Ionna, Francesco Longo, Corrado Aversa, Ettore Pavone, Maria Grazia Maglione, Massimiliano Di Marzo, Paolo Muto, Ernesta Cavalcanti, Antonella Petrillo, Fabio Sandomenico, Piera Maiolino, Roberta D’Aniello, Gerardo Botti, Rossella De Cecio, Nunzia Simona Losito, Stefania Scala, Annamaria Trotta, Andrea Ilaria Zotti, Francesca Bruzzese, Antonio Daponte, Ester Calogero, Massimo Montano, Monica Pontone, Gianfranco De Feo, Francesco Perri, Alfredo Budillon

Open Access Research article

Cancer-related fatigue in post-treatment cancer survivors: application of the common sense model of illness representations

Teresa Corbett, AnnMarie Groarke, Jane C. Walsh, Brian E. McGuire

Open Access Study protocol

Design of a randomized controlled trial of Internet-based cognitive behavioral therapy for treatment-induced menopausal symptoms in breast cancer survivors

Vera Atema, Marieke van Leeuwen, Hester S. A. Oldenburg, Valesca Retèl, Marc van Beurden, Myra S. Hunter, Neil K. Aaronson

Open Access Erratum

Erratum to: APC selectively mediates response to chemotherapeutic agents in breast cancer

Monica K. VanKlompenberg, Claire O. Bedalov, Katia Fernandez Soto, Jenifer R. Prosperi

Open Access Research article

HPV Prevalence in the Dutch cervical cancer screening population (DuSC study): HPV testing using automated HC2, cobas and Aptima workflows

Cornelis Johannes Jacobus Huijsmans, Willemina Rosalia Rita Geurts-Giele, Cindy Leeijen, Hendrikus Lambertus Cornelius Maria Hazenberg, Jenneke van Beek, Carola de Wild, Johannes Cornelis van der Linden, Adrianus Johannes Christiaan van den Brule

Open Access Research article

Genetic polymorphisms of FAS and EVER genes in a Greek population and their susceptibility to cervical cancer: a case control study

Evangelia Pavlidou, Alexandros Daponte, Raquel Egea, Efthimios Dardiotis, Georgios M. Hadjigeorgiou, Antonio Barbadilla, Theodoros Agorastos

Open Access Research article

Tumor characteristics and prognosis in familial breast cancer

G. Arpino, M. Pensabene, C. Condello, R. Ruocco, I. Cerillo, R. Lauria, V. Forestieri, M. Giuliano, C. De Angelis, M. Montella, A. Crispo, S. De Placido

Open Access Erratum

Erratum to: 53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells

Ruoxi Hong, Fei Ma, Weimin Zhang, Xiying Yu, Qing Li, Yang Luo, Changjun Zhu, Binghe Xu, Wei Jiang

Open Access Research article

Alternative splicing of estrogen receptor alpha in hepatocellular carcinoma

Jian Zhang, Jianwei Ren, Jiamin Wei, Charing C. N. Chong, Dongjie Yang, Yulong He, George G. Chen, Paul B. S. Lai

Open Access Research article

Preoperative conventional chemoradiotherapy versus short-course radiotherapy with delayed surgery for rectal cancer: results of a randomized controlled trial

Tadas Latkauskas, Henrikas Pauzas, Laura Kairevice, Aleksandras Petrauskas, Zilvinas Saladzinskas, Rasa Janciauskiene, Jurate Gudaityte, Paulius Lizdenis, Saulius Svagzdys, Algimantas Tamelis, Dainius Pavalkis

Open Access Research article

Computational prediction of multidisciplinary team decision-making for adjuvant breast cancer drug therapies: a machine learning approach

Frank P. Y. Lin, Adrian Pokorny, Christina Teng, Rachel Dear, Richard J. Epstein

Open Access Research article

The impact of medical tourism on colorectal screening among Korean Americans: A community-based cross-sectional study

Linda K. Ko, Victoria M. Taylor, Jihye Yoon, Wade K. Copeland, Joo Ha Hwang, Eun Jeong Lee, John Inadomi

Open Access Study protocol

Role of geriatric intervention in the treatment of older patients with cancer: rationale and design of a phase III multicenter trial

Pierre Soubeyran, Catherine Terret, Carine Bellera, Franck Bonnetain, Olivier Saint Jean, Angéline Galvin, Camille Chakiba, Marie-Dominique Zwolakowski, Simone Mathoulin-Pélissier, Muriel Rainfray

Open Access Research article

Analysing population-based cancer survival – settling the controversies

Maja Pohar Perme, Jacques Estève, Bernard Rachet

Open Access Research article

Germline mutations in BRCA1 and BRCA2 in epithelial ovarian cancer patients in Brazil

Simone Maistro, Natalia Teixeira, Giselly Encinas, Maria Lucia Hirata Katayama, Vivian Dionisio Tavares Niewiadonski, Larissa Garcia Cabral, Roberto Marques Ribeiro, Nelson Gaburo Junior, Ana Carolina Ribeiro Chaves de Gouvêa, Dirce Maria Carraro, Ester Cerdeira Sabino, Maria del Pilar Estevez Diz, Roger Chammas, Geertruida Hendrika de Bock, Maria Aparecida Azevedo Koike Folgueira

Open Access Research article

Predicting general and cancer-related distress in women with newly diagnosed breast cancer

Andrea Gibbons, AnnMarie Groarke, Karl Sweeney

Open Access Research article

Tumour stage distribution and survival of malignant melanoma in Germany 2002–2011

Olaf Schoffer, Stefanie Schülein, Gerlinde Arand, Hans Arnholdt, Dieter Baaske, Ralf C. Bargou, Nikolaus Becker, Matthias W. Beckmann, Yves Bodack, Beatrix Böhme, Tayfun Bozkurt, Regine Breitsprecher, Andre Buchali, Elke Burger, Ulrike Burger, Klaus Dommisch, Gudrun Elsner, Karin Fernschild, Ulrike Flintzer, Uwe Funke, Michael Gerken, Hubert Göbel, Norbert Grobe, Vera Gumpp, Lucie Heinzerling, Lana Raffaela Kempfer, Alexander Kiani, Monika Klinkhammer-Schalke, Sabine Klöcking, Ute Kreibich, Katrin Knabner, Peter Kuhn, Stine Lutze, Uwe Mäder, Tanja Maisel, Jan Maschke, Martin Middeke, Andreas Neubauer, Antje Niedostatek, Anabelle Opazo-Saez, Christoph Peters, Beatrice Schell, Gerhard Schenkirsch, Harald Schmalenberg, Peter Schmidt, Constanze Schneider, Birgit Schubotz, Anika Seide, Paul Strecker, Sabine Taubenheim, Matthias Wackes, Steffen Weiß, Claudia Welke, Carmen Werner, Christian Wittekind, Jörg Wulff, Heike Zettl, Stefanie J. Klug

Open Access Research article

Phosphodiesterases in non-neoplastic appearing colonic mucosa from patients with colorectal neoplasia

Badar Mahmood, Morten Matthiesen Bach Damm, Thorbjørn Søren Rønn Jensen, Marie Balslev Backe, Mattias Salling Dahllöf, Steen Seier Poulsen, Niels Bindslev, Mark Berner Hansen

Open Access Erratum

Erratum to: In vitro and in vivo activity of miR-92a–Locked Nucleic Acid (LNA)–Inhibitor against endometrial cancer

Anna Torres, Joanna Kozak, Agnieszka Korolczuk, Paulina Wdowiak, Ewa Domańska-Glonek, Ryszard Maciejewski, Kamil Torres

Open Access Research article

Innate immunity based cancer immunotherapy: B16-F10 murine melanoma model

Veronika Caisová, Andra Vieru, Zuzana Kumžáková, Simona Glaserová, Hana Husníková, Nikol Vácová, Gabriela Krejčová, Lucie Paďouková, Ivana Jochmanová, Katherine I. Wolf, Jindřich Chmelař, Jan Kopecký, Jan Ženka

Open Access Research article

Somatostatin signaling via SSTR1 contributes to the quiescence of colon cancer stem cells

Shirin R. Modarai, Lynn M. Opdenaker, Vignesh Viswanathan, Jeremy Z. Fields, Bruce M. Boman

Open Access Research article

Oral perfluorooctane sulfonate (PFOS) lessens tumor development in the APCmin mouse model of spontaneous familial adenomatous polyposis

Jeffrey Wimsatt, Meghan Villers, Laurel Thomas, Stacey Kamarec, Caitlin Montgomery, Leo W. Y. Yeung, Yanqing Hu, Kim Innes

Open Access Research article

Prediction of cancer progression in a group of 73 gastric cancer patients by circulating cell-free DNA

Wang-Yang Pu, Rong Zhang, Li Xiao, Yong-You Wu, Wei Gong, Xiao-Dong Lv, Feng-Yun Zhong, Zhi-Xiang Zhuang, Xu-Ming Bai, Kai Li, Chun-Gen Xing

Open Access Research article

The impact of gender difference on operative time in laparoscopic partial nephrectomy for T1 renal tumor and the utility of retroperitoneal fat thickness as a predictor of operative time

Hiroki Ito, Kazuhide Makiyama, Takashi Kawahara, Kimito Osaka, Koji Izumi, Yumiko Yokomizo, Noboru Nakaigawa, Masahiro Yao

Open Access Research article

Prognostic and predictive significance of long interspersed nucleotide element-1 methylation in advanced-stage colorectal cancer

Mami Kaneko, Masanori Kotake, Hiroyuki Bando, Tetsuji Yamada, Hirofumi Takemura, Toshinari Minamoto

Open Access Research article

A retrospective paired study: efficacy and toxicity of nimotuzumab versus cisplatin concurrent with radiotherapy in nasopharyngeal carcinoma

H. M. Li, P. Li, Y. J. Qian, X. Wu, L. Xie, F. Wang, H. Zhang, L. Liu

Open Access Case report

Transdifferentiation of pancreatic stromal tumor into leiomyosarcoma with metastases to liver and peritoneum: a case report

Chao Lin, Liping Wang, Jiyao Sheng, Dan Zhang, Lianyue Guan, Kai Zhao, Xuewen Zhang

Open Access Research article

Knockdown of ST6Gal-I increases cisplatin sensitivity in cervical cancer cells

Xiaopeng Zhang, Chunchen Pan, Lei Zhou, Zhaogen Cai, Shufang Zhao, Donghong Yu

Open Access Research article

Oral cancer incidence and survival rates in the Republic of Ireland, 1994-2009

Hala Ali, Sarah-Jo Sinnott, Paul Corcoran, Sandra Deady, Linda Sharp, Zubair Kabir

Open Access Research article

Agonists and knockdown of estrogen receptor β differentially affect invasion of triple-negative breast cancer cells in vitro

Susanne Schüler-Toprak, Julia Häring, Elisabeth C. Inwald, Christoph Moehle, Olaf Ortmann, Oliver Treeck

Open Access Research article

The effect of a germline mutation in the APC gene on β-catenin in human embryonic stem cells

Nofar Yedid, Yael Kalma, Mira Malcov, Ami Amit, Revital Kariv, Michal Caspi, Rina Rosin-Arbesfeld, Dalit Ben-Yosef

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