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Zeitschrift

BMC Cancer

BMC Cancer 1/2016

Ausgabe 1/2016

Inhaltsverzeichnis ( 948 Artikel )

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

A systematic review of geographical variation in access to chemotherapy

Charlotte Chamberlain, Amanda Owen-Smith, Jenny Donovan, William Hollingworth

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

All-trans retinoic acid synergizes with topotecan to suppress AML cells via promoting RARα-mediated DNA damage

Zhifei Xu, JinJin Shao, Lin Li, Xueming Peng, Min Chen, Guanqun Li, Hao Yan, Bo Yang, Peihua Luo, Qiaojun He

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

MicroRNA expression analysis in high fat diet-induced NAFLD-NASH-HCC progression: study on C57BL/6J mice

Alessandra Tessitore, Germana Cicciarelli, Filippo Del Vecchio, Agata Gaggiano, Daniela Verzella, Mariafausta Fischietti, Valentina Mastroiaco, Antonella Vetuschi, Roberta Sferra, Remo Barnabei, Daria Capece, Francesca Zazzeroni, Edoardo Alesse

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Prevalence and correlates of healthy lifestyle behaviors among early cancer survivors

Iris M. Kanera, Catherine A. W. Bolman, Ilse Mesters, Roy A. Willems, Audrey A. J. M. Beaulen, Lilian Lechner

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Population attributable risks of modifiable reproductive factors for breast and ovarian cancers in Korea

Boyoung Park, Sohee Park, Hai-Rim Shin, Aesun Shin, Yohwan Yeo, Ji-Yeob Choi, Kyu-Won Jung, Byoung-Gie Kim, Yong-Man Kim, Dong-Young Noh, Sei-Hyun Ahn, Jae Weon Kim, Sokbom Kang, Jae Hoon Kim, Tae Jin Kim, Daehee Kang, Keun-Young Yoo, Sue K. Park

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Successful en bloc venous resection with reconstruction and subsequent radiotherapy for 2 consecutive recurrences of intravenous leiomyoma—a case report

Ying Zhang, Leslie H. Clark, Xiugui Sheng, Chunxiao Zhou

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The role of GAGE cancer/testis antigen in metastasis: the jury is still out

Morten Frier Gjerstorff, Mikkel Green Terp, Malene Bredahl Hansen, Henrik Jørn Ditzel

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin in prostate cancer models

Giovanni Luca Gravina, Andrea Mancini, Patrizia Sanita, Flora Vitale, Francesco Marampon, Luca Ventura, Yosef Landesman, Dilara McCauley, Michael Kauffman, Sharon Shacham, Claudio Festuccia

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma

Yves-Paul Vandewynckel, Debby Laukens, Lindsey Devisscher, Eliene Bogaerts, Annelies Paridaens, Anja Van den Bussche, Sarah Raevens, Xavier Verhelst, Christophe Van Steenkiste, Bart Jonckx, Louis Libbrecht, Anja Geerts, Peter Carmeliet, Hans Van Vlierberghe

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

18F-fluoride positron emission tomography/computed tomography and bone scintigraphy for diagnosis of bone metastases in newly diagnosed, high-risk prostate cancer patients: study protocol for a multicentre, diagnostic test accuracy study

Randi F. Fonager, Helle D. Zacho, Niels C. Langkilde, Lars J. Petersen

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

RASSF1 tumor suppressor gene in pancreatic ductal adenocarcinoma: correlation of expression, chromosomal status and epigenetic changes

Eliana Amato, Stefano Barbi, Matteo Fassan, Claudio Luchini, Caterina Vicentini, Matteo Brunelli, Giuseppe Malleo, Aldo Scarpa, Giorgio Malpeli

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Lgr5 expression is a valuable prognostic factor for colorectal cancer: evidence from a meta-analysis

Yangyan Jiang, Wenlu Li, Xin He, Hongbo Zhang, Fangzhen Jiang, Zhigang Chen

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

GENESIS: a French national resource to study the missing heritability of breast cancer

Olga M. Sinilnikova, Marie-Gabrielle Dondon, Séverine Eon-Marchais, Francesca Damiola, Laure Barjhoux, Morgane Marcou, Carole Verny-Pierre, Valérie Sornin, Lucie Toulemonde, Juana Beauvallet, Dorothée Le Gal, Noura Mebirouk, Muriel Belotti, Olivier Caron, Marion Gauthier-Villars, Isabelle Coupier, Bruno Buecher, Alain Lortholary, Catherine Dugast, Paul Gesta, Jean-Pierre Fricker, Catherine Noguès, Laurence Faivre, Elisabeth Luporsi, Pascaline Berthet, Capucine Delnatte, Valérie Bonadona, Christine M. Maugard, Pascal Pujol, Christine Lasset, Michel Longy, Yves-Jean Bignon, Claude Adenis, Laurence Venat-Bouvet, Liliane Demange, Hélène Dreyfus, Marc Frenay, Laurence Gladieff, Isabelle Mortemousque, Séverine Audebert-Bellanger, Florent Soubrier, Sophie Giraud, Sophie Lejeune-Dumoulin, Annie Chevrier, Jean-Marc Limacher, Jean Chiesa, Anne Fajac, Anne Floquet, François Eisinger, Julie Tinat, Chrystelle Colas, Sandra Fert-Ferrer, Clotilde Penet, Thierry Frebourg, Marie-Agnès Collonge-Rame, Emmanuelle Barouk-Simonet, Valérie Layet, Dominique Leroux, Odile Cohen-Haguenauer, Fabienne Prieur, Emmanuelle Mouret-Fourme, François Cornélis, Philippe Jonveaux, Odile Bera, Eve Cavaciuti, Anne Tardivon, Fabienne Lesueur, Sylvie Mazoyer, Dominique Stoppa-Lyonnet, Nadine Andrieu

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Novel polymorphisms in caspase-8 are associated with breast cancer risk in the California Teachers Study

Hannah Lui Park, Argyrios Ziogas, Jenny Chang, Bhumi Desai, Leona Bessonova, Chad Garner, Eunjung Lee, Susan L. Neuhausen, Sophia S. Wang, Huiyan Ma, Jessica Clague, Peggy Reynolds, James V. Lacey Jr, Leslie Bernstein, Hoda Anton-Culver

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

CD133+ liver cancer stem cells resist interferon-gamma-induced autophagy

Jian Li, Jin-Na Chen, Ting-Ting Zeng, Fan He, Shu-Peng Chen, Stephanie Ma, Jiong Bi, Xiao-Feng Zhu, Xin-Yuan Guan

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Prognostic value of high FoxC2 expression in resectable non-small cell lung cancer, alone or in combination with E-cadherin expression

Wei Jiang, Hong Fan, Cheng Qian, Jianyong Ding, Qun Wang, Xuguang Pang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Silvestrol induces early autophagy and apoptosis in human melanoma cells

Wei-Lun Chen, Li Pan, A. Douglas Kinghorn, Steven M. Swanson, Joanna E. Burdette

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The lack of clinical value of peritoneal washing cytology in high risk patients undergoing risk-reducing salpingo-oophorectomy: a retrospective study and review

F. Blok, E. M. Roes, G. J. L. H. van Leenders, H. J. van Beekhuizen

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Cetuximab plus platinum-based chemotherapy in head and neck squamous cell carcinoma: a randomized, double-blind safety study comparing cetuximab produced from two manufacturing processes using the EXTREME study regimen

Denis Soulières, Jose Luis Aguilar, Eric Chen, Krzysztof Misiukiewicz, Scott Ernst, Hyun Jung Lee, Katherine Bryant, Shuang He, Coleman K. Obasaju, Shao-Chun Chang, Steve Chin, Douglas Adkins

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Prognostic value of protein inhibitor of activated STAT3 in breast cancer patients receiving hormone therapy

Sheau-Fang Yang, Ming-Feng Hou, Fang-Ming Chen, Fu Ou-Yang, Yang-Chang Wu, Chee-Yin Chai, Yao-Tsung Yeh

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

DocOx (AIO-PK0106): a phase II trial of docetaxel and oxaliplatin as a second line systemic therapy in patients with advanced pancreatic ductal adenocarcinoma

Thomas J. Ettrich, Lukas Perkhofer, Goetz von Wichert, Thomas M. Gress, Patrick Michl, Holger F. Hebart, Petra Büchner-Steudel, Michael Geissler, Rainer Muche, Bettina Danner, Volker Kächele, Andreas W. Berger, Melanie Güthle, Thomas Seufferlein

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Correlation of KIT and PDGFRA mutational status with clinical benefit in patients with gastrointestinal stromal tumor treated with sunitinib in a worldwide treatment-use trial

Peter Reichardt, George D. Demetri, Hans Gelderblom, Piotr Rutkowski, Seock-Ah Im, Sudeep Gupta, Yoon-Koo Kang, Patrick Schöffski, Jochen Schuette, Denis Soulières, Jean-Yves Blay, David Goldstein, Kolette Fly, Xin Huang, Massimo Corsaro, Maria Jose Lechuga, Jean-Francois Martini, Michael C. Heinrich

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

A potent betulinic acid analogue ascertains an antagonistic mechanism between autophagy and proteasomal degradation pathway in HT-29 cells

Debasmita Dutta, Biswajit Chakraborty, Ankita Sarkar, Chinmay Chowdhury, Padma Das

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine

Dannel Yeo, Hong He, Oneel Patel, Andrew M. Lowy, Graham S. Baldwin, Mehrdad Nikfarjam

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Dronabinol has preferential antileukemic activity in acute lymphoblastic and myeloid leukemia with lymphoid differentiation patterns

Kerstin Maria Kampa-Schittenhelm, Olaf Salitzky, Figen Akmut, Barbara Illing, Lothar Kanz, Helmut Rainer Salih, Marcus Matthias Schittenhelm

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Novel c-Met inhibitor suppresses the growth of c-Met-addicted gastric cancer cells

Chi Hoon Park, Sung Yun Cho, Jae Du Ha, Heejung Jung, Hyung Rae Kim, Chong Ock Lee, In-Young Jang, Chong Hak Chae, Heung Kyoung Lee, Sang Un Choi

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: RIZ1: a potential tumor suppressor in glioma

Chenran Zhang, Qiubei Zhu, Hua He, Lei Jiang, Qiang Qiang, Liuhua Hu, Guohan Hu, Ying Jiang, Xuehua Ding, Yicheng Lu

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Genetic heterogeneity of actionable genes between primary and metastatic tumor in lung adenocarcinoma

Eun Young Kim, Eun Na Cho, Heae Surng Park, Arum Kim, Ji Young Hong, Seri Lim, Jong Pil Youn, Seung Yong Hwang, Yoon Soo Chang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Mutations in TP53 increase the risk of SOX2 copy number alterations and silencing of TP53 reduces SOX2 expression in non-small cell lung cancer

Johanna Samulin Erdem, Vidar Skaug, Per Bakke, Amund Gulsvik, Aage Haugen, Shanbeh Zienolddiny

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Correlation analyses between pre- and post-operative adverse events in gastric cancer patients receiving preoperative treatment and gastrectomy

Shuang-Xi Li, Sang Hyuk Seo, Yoon Young Choi, Masatoshi Nakagawa, Ji Yeong An, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Sung Hoon Noh

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Trabectedin for inoperable or recurrent soft tissue sarcoma in adult patients: a retrospective cohort study

Fernando A. Angarita, Amanda J. Cannell, Albiruni R. Abdul Razak, Brendan C. Dickson, Martin E. Blackstein

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

(Secondary) solid tumors in thyroid cancer patients treated with the multi-kinase inhibitor sorafenib may present diagnostic challenges

Tatiana C. Schneider, Ellen Kapiteijn, Tom van Wezel, Jan W. A. Smit, Jacobus J. M. van der Hoeven, Hans Morreau

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Regulatory dissection of the CBX5 and hnRNPA1 bi-directional promoter in human breast cancer cells reveals novel transcript variants differentially associated with HP1α down-regulation in metastatic cells

Johan Vad-Nielsen, Kristine Raaby Jakobsen, Tina Fuglsang Daugaard, Rune Thomsen, Anja Brügmann, Boe Sandahl Sørensen, Anders Lade Nielsen

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

MIR494 reduces renal cancer cell survival coinciding with increased lipid droplets and mitochondrial changes

Punashi Dutta, Edward Haller, Arielle Sharp, Meera Nanjundan

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines

Haatisha Jandu, Kristina Aluzaite, Louise Fogh, Sebastian Wingaard Thrane, Julie B. Noer, Joanna Proszek, Khoa Nguyen Do, Stine Ninel Hansen, Britt Damsgaard, Signe Lykke Nielsen, Magnus Stougaard, Birgitta R. Knudsen, José Moreira, Petra Hamerlik, Madhavsai Gajjar, Marcel Smid, John Martens, John Foekens, Yves Pommier, Nils Brünner, Anne-Sofie Schrohl, Jan Stenvang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Clinicopathological analysis in patients with neuroendocrine tumors that metastasized to the brain

Jiro Akimoto, Hirokazu Fukuhara, Tomohiro Suda, Kenta Nagai, Megumi Ichikawa, Shinjiro Fukami, Michihiro Kohno, Jun Matsubayashi, Toshitaka Nagao

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Molecular targeted photoimmunotherapy for HER2-positive human gastric cancer in combination with chemotherapy results in improved treatment outcomes through different cytotoxic mechanisms

Kimihiro Ito, Makoto Mitsunaga, Seiji Arihiro, Masayuki Saruta, Mika Matsuoka, Hisataka Kobayashi, Hisao Tajiri

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

LINE-1 silencing by retinoblastoma proteins is effected through the nucleosomal and remodeling deacetylase multiprotein complex

Diego E. Montoya-Durango, Kenneth A. Ramos, Pasano Bojang, Lorell Ruiz, Irma N. Ramos, Kenneth S. Ramos

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Aspirin inhibits epithelial-to-mesenchymal transition and migration of oncogenic K-ras-expressing non-small cell lung carcinoma cells by down-regulating E-cadherin repressor Slug

Poulami Khan, Argha Manna, Shilpi Saha, Suchismita Mohanty, Shravanti Mukherjee, Minakshi Mazumdar, Deblina Guha, Tanya Das

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Gene methylation profile of gastric cancerous tissue according to tumor site in the stomach

Rita Kupcinskaite-Noreikiene, Rasa Ugenskiene, Alius Noreika, Viktoras Rudzianskas, Jurgita Gedminaite, Jurgita Skieceviciene, Elona Juozaityte

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Pre-treatment neutrophil to lymphocyte ratio predicts the chemoradiotherapy outcome and survival in patients with oral squamous cell carcinoma: a retrospective study

Hikaru Nakashima, Yuichiro Matsuoka, Ryoji Yoshida, Masashi Nagata, Akiyuki Hirosue, Kenta Kawahara, Junki Sakata, Hidetaka Arita, Akimitsu Hiraki, Hideki Nakayama

01.12.2016 | Correspondence | Ausgabe 1/2016 Open Access

Asian expert recommendation on management of skin and mucosal effects of radiation, with or without the addition of cetuximab or chemotherapy, in treatment of head and neck squamous cell carcinoma

Guopei Zhu, Jin-Ching Lin, Sung-Bae Kim, Jacques Bernier, Jai Prakash Agarwal, Jan B. Vermorken, Dang Huy Quoc Thinh, Hoi-Ching Cheng, Hwan Jung Yun, Imjai Chitapanarux, Prasert Lertsanguansinchai, Vijay Anand Reddy, Xia He

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Thrombocytosis and hyperfibrinogenemia are predictive factors of clinical outcomes in high-grade serous ovarian cancer patients

Zheng Feng, Hao Wen, Rui Bi, Yachen Duan, Wentao Yang, Xiaohua Wu

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Impact of the introduction of EBUS on time to management decision, complications, and invasive modalities used to diagnose and stage lung cancer: a pragmatic pre-post study

Neli S. Slavova-Azmanova, Catalina Lizama, Claire E. Johnson, Herbert P. Ludewick, Leanne Lester, Shanka Karunarathne, Martin Phillips

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Both Talin-1 and Talin-2 correlate with malignancy potential of the human hepatocellular carcinoma MHCC-97 L cell

Kun-peng Fang, Wei Dai, Yan-Hong Ren, Ye-Chuan Xu, She-min Zhang, Ye-Ben Qian

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Long-term use of lenalidomide and low-dose dexamethasone in Chinese patients with relapsed/refractory multiple myeloma: MM-024 Extended Access Program

Xin Du, Jie Jin, Zhen Cai, Fangping Chen, Dao-bin Zhou, Li Yu, Xiaoyan Ke, Xiao Li, Depei Wu, Fanyi Meng, Dena DeMarco, Jingshan Zhang, Jay Mei, Jian Hou

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer

Ryan A. Denu, Lauren M. Zasadil, Craig Kanugh, Jennifer Laffin, Beth A. Weaver, Mark E. Burkard

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Cancer survival in New South Wales, Australia: socioeconomic disparities remain despite overall improvements

Julia F. Stanbury, Peter D. Baade, Yan Yu, Xue Qin Yu

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The dual specificity phosphatase 2 gene is hypermethylated in human cancer and regulated by epigenetic mechanisms

Tanja Haag, Antje M. Richter, Martin B. Schneider, Adriana P. Jiménez, Reinhard H. Dammann

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

US-localized diffuse optical tomography in breast cancer: comparison with pharmacokinetic parameters of DCE-MRI and with pathologic biomarkers

Min Jung Kim, Min-Ying Su, Hon J Yu, Jeon-Hor Chen, Eun-Kyung Kim, Hee Jung Moon, Ji Soo Choi

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Low oxygen tension reverses antineoplastic effect of iron chelator deferasirox in human glioblastoma cells

Claire Legendre, Sylvie Avril, Catherine Guillet, Emmanuel Garcion

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Associations of microbiota and toll-like receptor signaling pathway in esophageal adenocarcinoma

Ali H. Zaidi, Lori A. Kelly, Rachael E. Kreft, Mark Barlek, Ashten N. Omstead, Daisuke Matsui, Natalie H. Boyd, Kathryn E. Gazarik, Megan I. Heit, Laura Nistico, Pashtoon M. Kasi, Tracy L. Spirk, Barbara Byers, Emily J. Lloyd, Rodney J. Landreneau, Blair A. Jobe

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Cooperation of Sox4 with β-catenin/p300 complex in transcriptional regulation of the Slug gene during divergent sarcomatous differentiation in uterine carcinosarcoma

Hisako Inoue, Hiroyuki Takahashi, Miki Hashimura, Koji Eshima, Masashi Akiya, Toshihide Matsumoto, Makoto Saegusa

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Establishment and characterization of a metastasis model of human gastric cancer in nude mice

Kesheng Li, Huifen Du, Xiaowen Lian, Dandan Chai, Xinwen Li, Rong Yang, Chunya Wang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility

Hui-min Zhou, Yuan-yuan Fang, Paul M. Weinberger, Ling-ling Ding, John K. Cowell, Farlyn Z. Hudson, Mingqiang Ren, Jeffrey R. Lee, Qi-kui Chen, Hong Su, William S. Dynan, Ying Lin

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Fusion with stem cell makes the hepatocellular carcinoma cells similar to liver tumor-initiating cells

Ran Wang, Shuxun Chen, Changxian Li, Kevin Tak Pan Ng, Chi-wing Kong, Jinping Cheng, Shuk Han Cheng, Ronald A. Li, Chung Mau Lo, Kwan Man, Dong Sun

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Cancer risk in East Asian patients associated with acquired haemolytic anaemia: a nationwide population-based cohort study

Victor C. Kok, Fung-Chang Sung, Chia-Hung Kao, Che-Chen Lin, Chun-Hung Tseng

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Dietary leucine supplementation minimises tumour-induced damage in placental tissues of pregnant, tumour-bearing rats

Bread Leandro Gomes Cruz, Priscila Cristina da Silva, Rebeka Tomasin, Andre Gustavo Oliveira, Lais Rosa Viana, Emilianne Miguel Salomao, Maria Cristina Cintra Gomes-Marcondes

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Metabolic syndrome diagnosis and widespread high grade prostatic intraepithelial neoplasia significantly increase prostate cancer risk: results from a multicenter biopsy study

Antonio Cicione, Cosimo De Nunzio, Andrea Tubaro, Francesco Cantiello, Stefano Manno, Carlos Oliveira, Estevao Lima, Rocco Damiano

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Differences in TGF-β1 signaling and clinicopathologic characteristics of histologic subtypes of gastric cancer

Kyung Ho Pak, Dong Hoon Kim, Hyunki Kim, Do Hyung Lee, Jae-Ho Cheong

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Feasibility outcomes of a presurgical randomized controlled trial exploring the impact of caloric restriction and increased physical activity versus a wait-list control on tumor characteristics and circulating biomarkers in men electing prostatectomy for prostate cancer

Wendy Demark-Wahnefried, Jeffery W. Nix, Gary R. Hunter, Soroush Rais-Bahrami, Renee A. Desmond, Balu Chacko, Casey D. Morrow, Maria Azrad, Andrew D. Frugé, Yuko Tsuruta, Travis Ptacek, Scott A. Tully, Roanne Segal, William E. Grizzle

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Metastatic EML4-ALK fusion detected by circulating DNA genotyping in an EGFR-mutated NSCLC patient and successful management by adding ALK inhibitors: a case report

Wenhua Liang, Qihua He, Ying Chen, Shaokun Chuai, Weiqiang Yin, Wei Wang, Guilin Peng, Caicun Zhou, Jianxing He

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

High mannose-binding Pseudomonas fluorescens lectin (PFL) downregulates cell surface integrin/EGFR and induces autophagy in gastric cancer cells

Yuichiro Sato, Takanori Kubo, Kinjiro Morimoto, Kazuyoshi Yanagihara, Toshio Seyama

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Novel germline mutations and unclassified variants of BRCA1 and BRCA2 genes in Chinese women with familial breast/ovarian cancer

Wen-Ming Cao, Yun Gao, Hong-Jian Yang, Shang-Nao Xie, Xiao-Wen Ding, Zhi-Wen Pan, Wei-Wu Ye, Xiao-Jia Wang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Pitfalls of practicing cancer epidemiology in resource-limited settings: the case of survival and loss to follow-up after a diagnosis of Kaposi’s sarcoma in five countries across sub-Saharan Africa

Esther Freeman, Aggrey Semeere, Megan Wenger, Mwebesa Bwana, F. Chite Asirwa, Naftali Busakhala, Emmanuel Oga, Elima Jedy-Agba, Vivian Kwaghe, Kenneth Iregbu, Antoine Jaquet, Francois Dabis, Habakkuk Azinyui Yumo, Jean Claude Dusingize, David Bangsberg, Kathryn Anastos, Sam Phiri, Julia Bohlius, Matthias Egger, Constantin Yiannoutsos, Kara Wools-Kaloustian, Jeffrey Martin

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Scenario drafting for early technology assessment of next generation sequencing in clinical oncology

S.E.P. Joosten, V.P. Retèl, V.M.H. Coupé, M.M. van den Heuvel, W.H. van Harten

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

FDG PET/CT as a prognostic biomarker in the era of molecular-targeting therapies: max SUVmax predicts survival of patients with advanced renal cell carcinoma

Noboru Nakaigawa, Keiichi Kondo, Ukihide Tateishi, Ryogo Minamimoto, Tomohiro Kaneta, Kazuhiro Namura, Daiki Ueno, Kazuki Kobayashi, Takeshi Kishida, Ichiro Ikeda, Hisashi Hasumi, Kazuhide Makiyama, Yoshinobu Kubota, Tomio Inoue, Masahiro Yao

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Optimal regimen of trastuzumab in combination with oxaliplatin/ capecitabine in first-line treatment of HER2-positive advanced gastric cancer (CGOG1001): a multicenter, phase II trial

Jifang Gong, Tianshu Liu, Qingxia Fan, Li Bai, Feng Bi, Shukui Qin, Jinwan Wang, Nong Xu, Ying Cheng, Yuxian Bai, Wei Liu, Liwei Wang, Lin Shen

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

A randomized phase 3 study on the optimization of the combination of bevacizumab with FOLFOX/OXXEL in the treatment of patients with metastatic colorectal cancer-OBELICS (Optimization of BEvacizumab scheduLIng within Chemotherapy Scheme)

Antonio Avallone, Maria Carmela Piccirillo, Luigi Aloj, Guglielmo Nasti, Paolo Delrio, Francesco Izzo, Elena Di Gennaro, Fabiana Tatangelo, Vincenza Granata, Ernesta Cavalcanti, Piera Maiolino, Francesco Bianco, Pasquale Aprea, Mario De Bellis, Biagio Pecori, Gerardo Rosati, Chiara Carlomagno, Alessandro Bertolini, Ciro Gallo, Carmela Romano, Alessandra Leone, Corradina Caracò, Elisabetta de Lutio di Castelguidone, Gennaro Daniele, Orlando Catalano, Gerardo Botti, Antonella Petrillo, Giovanni M. Romano, Vincenzo R. Iaffaioli, Secondo Lastoria, Francesco Perrone, Alfredo Budillon

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The MYCN-HMGA2-CDKN2A pathway in non-small cell lung carcinoma—differences in histological subtypes

Hanne A. Eide, Ann Rita Halvorsen, Maria Moksnes Bjaanæs, Hossein Piri, Ruth Holm, Steinar Solberg, Lars Jørgensen, Odd Terje Brustugun, Cecilie Essholt Kiserud, Åslaug Helland

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Site disparities in apoptotic variants as predictors of risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck

Yan Sun, Wenbin Yu, Erich M. Sturgis, Wei Peng, Dapeng Lei, Qingyi Wei, Xicheng Song, Guojun Li

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Evaluation of TgH(CX3CR1-EGFP) mice implanted with mCherry-GL261 cells as an in vivo model for morphometrical analysis of glioma-microglia interaction

Fernando F. B. Resende, Xianshu Bai, Elaine Aparecida Del Bel, Frank Kirchhoff, Anja Scheller, Ricardo Titze-de-Almeida

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Computerized tomography angiography in preoperative assessment of intravenous leiomyomatosis extending to inferior vena cava and heart

Ting Gui, Qiuhong Qian, Dongyan Cao, Jiaxin Yang, Ping Peng, Keng Shen

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

A pharmacogenetic pilot study reveals MTHFR, DRD3, and MDR1 polymorphisms as biomarker candidates for slow atorvastatin metabolizers

Rafael B. R. León-Cachón, Jorge A. Ascacio-Martínez, María E. Gamino-Peña, Ricardo M. Cerda-Flores, Irene Meester, Hugo L. Gallardo-Blanco, Magdalena Gómez-Silva, Everardo Piñeyro-Garza, Hugo A. Barrera-Saldaña

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Molecular pathways leading to loss of skeletal muscle mass in cancer cachexia – can findings from animal models be translated to humans?

Tara C. Mueller, Jeannine Bachmann, Olga Prokopchuk, Helmut Friess, Marc E. Martignoni

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Using gene expression from urine sediment to diagnose prostate cancer: development of a new multiplex mRNA urine test and validation of current biomarkers

Lourdes Mengual, Juan José Lozano, Mercedes Ingelmo-Torres, Laura Izquierdo, Mireia Musquera, María José Ribal, Antonio Alcaraz

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Prediction of anticancer molecules using hybrid model developed on molecules screened against NCI-60 cancer cell lines

Harinder Singh, Rahul Kumar, Sandeep Singh, Kumardeep Chaudhary, Ankur Gautam, Gajendra P. S. Raghava

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Tumor slice culture system to assess drug response of primary breast cancer

Kishan A. T. Naipal, Nicole S. Verkaik, Humberto Sánchez, Carolien H. M. van Deurzen, Michael A. den Bakker, Jan H.J. Hoeijmakers, Roland Kanaar, Maaike P.G. Vreeswijk, Agnes Jager, Dik C. van Gent

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Evaluating early response of cervical cancer under concurrent chemo-radiotherapy by intravoxel incoherent motion MR imaging

Li Zhu, Lijing Zhu, Hua Shi, Huanhuan Wang, Jing Yan, Baorui Liu, Weibo Chen, Jian He, Zhengyang Zhou, Xiaofeng Yang, Tian Liu

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Inflammatory biomarker score and cancer: A population-based prospective cohort study

Leavitt Morrison, Jari A. Laukkanen, Kimmo Ronkainen, Sudhir Kurl, Jussi Kauhanen, Adetunji T. Toriola

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Chemotherapy with BCNU in recurrent glioma: Analysis of clinical outcome and side effects in chemotherapy-naïve patients

Christine Jungk, Despina Chatziaslanidou, Rezvan Ahmadi, David Capper, Justo Lorenzo Bermejo, Janina Exner, Andreas von Deimling, Christel Herold-Mende, Andreas Unterberg

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Capecitabine in the routine first-line treatment of elderly patients with advanced colorectal cancer - results from a non-interventional observation study

Alexander Stein, Julia Quidde, Jan Klaus Schröder, Thomas Göhler, Barbara Tschechne, Annette-Rosel Valdix, Heinz-Gert Höffkes, Silke Schirrmacher-Memmel, Tim Wohlfarth, Axel Hinke, Andreas Engelen, Dirk Arnold

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Lack of association between polymorphisms in the CYP1A2 gene and risk of cancer: evidence from meta-analyses

Vladimir Vukovic, Carolina Ianuale, Emanuele Leoncini, Roberta Pastorino, Maria Rosaria Gualano, Rosarita Amore, Stefania Boccia

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Impact of Bevacizumab on parenchymal damage and functional recovery of the liver in patients with colorectal liver metastases

Andreas M. Volk, Johannes Fritzmann, Christoph Reissfelder, Georg F. Weber, Jürgen Weitz, Nuh N. Rahbari

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

HOX transcription factors are potential targets and markers in malignant mesothelioma

Richard Morgan, Guy Simpson, Sophie Gray, Cheryl Gillett, Zsuzsanna Tabi, James Spicer, Kevin J. Harrington, Hardev S. Pandha

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Regulation of the tumour suppressor PDCD4 by miR-499 and miR-21 in oropharyngeal cancers

Xiaoying Zhang, Harriet Gee, Barbara Rose, C. Soon Lee, Jonathan Clark, Michael Elliott, Jennifer R. Gamble, Murray J. Cairns, Adrian Harris, Samantha Khoury, Nham Tran

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Parallelism of DOG1 expression with recurrence risk in gastrointestinal stromal tumors bearing KIT or PDGFRA mutations

Francesca Maria Rizzo, Raffaele Palmirotta, Andrea Marzullo, Nicoletta Resta, Mauro Cives, Marco Tucci, Franco Silvestris

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Distinct genomic and epigenomic features demarcate hypomethylated blocks in colon cancer

Mahfuza Sharmin, Héctor Corrada Bravo, Sridhar Hannenhalli

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Comparative immunogenicity and structural analysis of epitopes of different bacterial L-asparaginases

Vadim S. Pokrovsky, Marat D. Kazanov, Ilya N. Dyakov, Marina V. Pokrovskaya, Svetlana S. Aleksandrova

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Establishment of a patient-derived intrahepatic cholangiocarcinoma xenograft model with KRAS mutation

Giuliana Cavalloni, Caterina Peraldo-Neia, Francesco Sassi, Giovanna Chiorino, Ivana Sarotto, Massimo Aglietta, Francesco Leone

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

A phase II study of Epirubicin in oxaliplatin-resistant patients with metastatic colorectal cancer and TOP2A gene amplification

Line S. Tarpgaard, Camilla Qvortrup, Sune B. Nygård, Signe L. Nielsen, Diana R. Andersen, Niels Frank Jensen, Jan Stenvang, Sönke Detlefsen, Nils Brünner, Per Pfeiffer

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

A nomogram for predicting the likelihood of lymph node metastasis in early gastric patients

Zhixue Zheng, Yinan Zhang, Lianhai Zhang, Ziyu Li, Xiaojiang Wu, Yiqiang Liu, Zhaode Bu, Jiafu Ji

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Effects of receptor for advanced glycation endproducts on microvessel formation in endometrial cancer

Lu Zheng, Da Li, Yi-Ming Zhou, Hui Yang, Di Cheng, Xiao-Xin Ma

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Organic Cation Transporter 1 (OCT1) mRNA expression in hepatocellular carcinoma as a biomarker for sorafenib treatment

Daniel Grimm, Jonas Lieb, Veronika Weyer, Johanna Vollmar, Felix Darstein, Anja Lautem, Maria Hoppe-Lotichius, Sandra Koch, Arno Schad, Jörn M. Schattenberg, Marcus A. Wörns, Arndt Weinmann, Peter R. Galle, Tim Zimmermann

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The prognostic value of stromal and epithelial periostin expression in human breast cancer: correlation with clinical pathological features and mortality outcome

P. V. Nuzzo, A. Rubagotti, L. Zinoli, S. Salvi, S. Boccardo, F. Boccardo

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Attitudes towards the Faecal Occult Blood Test (FOBT) versus the Faecal Immunochemical Test (FIT) for colorectal cancer screening: perceived ease of completion and disgust

Julie A. Chambers, Alana S. Callander, Rebecca Grangeret, Ronan E. O’Carroll

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Select Bcl-2 antagonism restores chemotherapy sensitivity in high-risk neuroblastoma

Rachel Tanos, Dipan Karmali, Srilatha Nalluri, Kelly C. Goldsmith

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Follicular thyroid carcinoma but not adenoma recruits tumor-associated macrophages by releasing CCL15

Feng-Jiao Huang, Xiao-Yi Zhou, Lei Ye, Xiao-Chun Fei, Shu Wang, Weiqing Wang, Guang Ning

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: Differences in TGF-β1 signaling and clinicopathologic characteristics of histologic subtypes of gastric cancer

Kyung Ho Pak, Dong Hoon Kim, Hyunki Kim, Do Hyung Lee, Jae-Ho Cheong

01.12.2016 | Reviewer Acknowledgement | Ausgabe 1/2016 Open Access

BMC Cancer reviewer acknowledgement 2015

Dafne Solera

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

MiR-193b promotes autophagy and non-apoptotic cell death in oesophageal cancer cells

Michelle J. Nyhan, Tracey R. O’Donovan, Antonius W. M. Boersma, Erik A. C. Wiemer, Sharon L. McKenna

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Expression and promotor hypermethylation of miR-34a in the various histological subtypes of ovarian cancer

Gabriel Schmid, Sara Notaro, Daniel Reimer, Samira Abdel-Azim, Michaela Duggan-Peer, Jessica Holly, Heidi Fiegl, Julia Rössler, Annemarie Wiedemair, Nicole Concin, Peter Altevogt, Christian Marth, Alain Gustave Zeimet

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

BCORL1 is an independent prognostic marker and contributes to cell migration and invasion in human hepatocellular carcinoma

Guozhi Yin, Zhikui Liu, Yufeng Wang, Changwei Dou, Chao Li, Wei Yang, Yingmin Yao, Qingguang Liu, Kangsheng Tu

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Epidemiology of childhood and adolescent cancer in Bangladesh, 2001–2014

Mohammad Sorowar Hossain, Mamtaz Begum, Md Mahmuduzzaman Mian, Shameema Ferdous, Shahinur Kabir, Humayun Kabir Sarker, Sabina Karim, Salma Choudhury, Asaduzzaman Khan, Zohora Jameela Khan, Henrike E. Karim-Kos

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification

Jieyi Wang, Liliane Goetsch, Lora Tucker, Qian Zhang, Alexandra Gonzalez, Kedar S. Vaidya, Anatol Oleksijew, Erwin Boghaert, Minghao Song, Irina Sokolova, Ekaterina Pestova, Mark Anderson, William N. Pappano, Peter Ansell, Anahita Bhathena, Louie Naumovski, Nathalie Corvaia, Edward B. Reilly

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Isolated tumor cells in stage I & II colon cancer patients are associated with significantly worse disease-free and overall survival

B. Weixler, R. Warschkow, U. Güller, A. Zettl, U. von Holzen, B. M. Schmied, M. Zuber

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The combination of blue dye and radioisotope versus radioisotope alone during sentinel lymph node biopsy for breast cancer: a systematic review

Pei-Sheng He, Feng Li, Guan-Hua Li, Can Guo, Tian-Jin Chen

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

MiRNA-146b-5p upregulates migration and invasion of different Papillary Thyroid Carcinoma cells

Cilene Rebouças Lima, Murilo Vieira Geraldo, Cesar Seigi Fuziwara, Edna Teruko Kimura, Marinilce Fagundes Santos

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Prognostic value of a computer-aided diagnosis system involving bone scans among men treated with docetaxel for metastatic castration-resistant prostate cancer

Koichi Uemura, Yasuhide Miyoshi, Takashi Kawahara, Shuko Yoneyama, Yusuke Hattori, Jun-ichi Teranishi, Keiichi Kondo, Masatoshi Moriyama, Shigeo Takebayashi, Yumiko Yokomizo, Masahiro Yao, Hiroji Uemura, Kazumi Noguchi

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Bevacizumab for metachronous metastatic colorectal cancer: a reflection of community based practice

L. G. E. M. Razenberg, Y. R. B. M. van Gestel, I. H. J. T. de Hingh, O. J. L. Loosveld, G. Vreugdenhil, L. V. Beerepoot, G. J. Creemers, V. E. P. P. Lemmens

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Pretreatment neutrophil-to-lymphocyte ratio predicts the prognosis in patients with metastatic prostate cancer

Takashi Kawahara, Yumiko Yokomizo, Yusuke Ito, Hiroki Ito, Hitoshi Ishiguro, Jun-ichi Teranishi, Kazuhide Makiyama, Yasuhide Miyoshi, Hiroshi Miyamoto, Masahiro Yao, Hiroji Uemura

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Characterising timing and pattern of relapse following surgery for localised oesophagogastric adenocarcinoma: a retrospective study

Sing Yu Moorcraft, Elisa Fontana, David Cunningham, Clare Peckitt, Tom Waddell, Elizabeth C. Smyth, William Allum, Jeremy Thompson, Sheela Rao, David Watkins, Naureen Starling, Ian Chau

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Promoter methylation of ITF2, but not APC, is associated with microsatellite instability in two populations of colorectal cancer patients

Andrea J. Savio, Darshana Daftary, Elizabeth Dicks, Daniel D. Buchanan, Patrick S. Parfrey, Joanne P. Young, Daniel Weisenberger, Roger C. Green, Steven Gallinger, John R. McLaughlin, Julia A. Knight, Bharati Bapat

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Prognostic value of the distance between the primary tumor and brainstem in the patients with locally advanced nasopharyngeal carcinoma

Yuxiang He, Ying Wang, Lin Shen, Yajie Zhao, Pengfei Cao, Mingjun Lei, Dengming Chen, Tubao Yang, Liangfang Shen, Shousong Cao

01.12.2016 | Technical advance | Ausgabe 1/2016 Open Access

MB3W1 is an orthotopic xenograft model for anaplastic medulloblastoma displaying cancer stem cell- and Group 3-properties

Sebastian Dietl, Stefanie Schwinn, Susanne Dietl, Simone Riedel, Frank Deinlein, Stefan Rutkowski, Andre O. von Bueren, Jürgen Krauss, Tilmann Schweitzer, Giles H. Vince, Daniel Picard, Matthias Eyrich, Andreas Rosenwald, Vijay Ramaswamy, Michael D. Taylor, Marc Remke, Camelia M. Monoranu, Andreas Beilhack, Paul G. Schlegel, Matthias Wölfl

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Predictive and prognostic value of PET/CT imaging post-chemoradiotherapy and clinical decision-making consequences in locally advanced head & neck squamous cell carcinoma: a retrospective study

Ryul Kim, Chan-Young Ock, Bhumsuk Keam, Tae Min Kim, Jin Ho Kim, Jin Chul Paeng, Seong Keun Kwon, J. Hun Hah, Tack-Kyun Kwon, Dong-Wan Kim, Hong-Gyun Wu, Myung-Whun Sung, Dae Seog Heo

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: Results of multicenter double-blind placebo-controlled phase II clinical trial of Panagen preparation to evaluate its leukostimulatory activity and formation of the adaptive immune response in patients with stage II-IV breast cancer

Anastasia S. Proskurina, Tatiana S. Gvozdeva, Ekaterina A. Alyamkina, Evgenia V. Dolgova, Konstantin E. Orishchenko, Valeriy P. Nikolin, Nelly A. Popova, Sergey V. Sidorov, Elena R. Chernykh, Alexandr A. Ostanin, Olga Y. Leplina, Victoria V. Dvornichenko, Dmitriy M. Ponomarenko, Galina S. Soldatova, Nikolay A. Varaksin, Tatiana G. Ryabicheva, Peter N. Uchakin, Stanislav N. Zagrebelniy, Vladimir A. Rogachev, Sergey S. Bogachev, Mikhail A. Shurdov

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Paraneoplastic lipase and amylase production in a patient with small-cell lung cancer: case report

Andrea Casadei Gardini, Marita Mariotti, Alessandro Lucchesi, Sara Pini, Martina Valgiusti, Sara Bravaccini, Angelo Del Monte, Marco Angelo Burgio, Giorgia Marisi, Dino Amadori, Giovanni Luca Frassineti

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Breast cancer literacy among higher secondary students: results from a cross-sectional study in Western Nepal

Parash Mani Bhandari, Kiran Thapa, Sarmila Dhakal, Shristi Bhochhibhoya, Rashmi Deuja, Pawan Acharya, Shiva Raj Mishra

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The impact of KRAS mutations on prognosis in surgically resected colorectal cancer patients with liver and lung metastases: a retrospective analysis

Hae Su Kim, Jin Seok Heo, Jeeyun Lee, Ji Yun Lee, Min-Young Lee, Sung Hee Lim, Woo Yong Lee, Seok Hyung Kim, Yoon Ah Park, Yong Beom Cho, Seong Hyeon Yun, Seung Tae Kim, Joon Oh Park, Ho Yeong Lim, Yong Soo Choi, Woo Il Kwon, Hee Cheol Kim, Young Suk Park

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Phase II study on the efficacy and safety of Lapatinib administered beyond disease progression and combined with vinorelbine in HER-2/neu– positive advanced breast cancer: results of the CECOG LaVie trial

Christiane Thallinger, Istvan Lang, Cvetka Grasic Kuhar, Rupert Bartsch, Christian F. Singer, Lubos Petruzelka, Bohuslav Melichar, Regina Knittelfelder, Thomas Brodowicz, Christoph Zielinski

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Methodology of health-related quality of life analysis in phase III advanced non-small-cell lung cancer clinical trials: a critical review

Frédéric Fiteni, Amélie Anota, Virginie Westeel, Franck Bonnetain

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

An 8-gene mRNA expression profile in circulating tumor cells predicts response to aromatase inhibitors in metastatic breast cancer patients

Esther A. Reijm, Anieta M. Sieuwerts, Marcel Smid, Joan Bolt-de Vries, Bianca Mostert, Wendy Onstenk, Dieter Peeters, Luc Y. Dirix, Caroline M. Seynaeve, Agnes Jager, Felix E. de Jongh, Paul Hamberg, Anne van Galen, Jaco Kraan, Maurice P. H. M. Jansen, Jan W. Gratama, John A. Foekens, John W. M. Martens, Els M. J. J. Berns, Stefan Sleijfer

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Systemic inflammation is an independent predictive marker of clinical outcomes in mucosal squamous cell carcinoma of the head and neck in oropharyngeal and non-oropharyngeal patients

Kellie A. Charles, Benjamin D. W. Harris, Carol R. Haddad, Stephen J. Clarke, Alex Guminski, Mark Stevens, Tristan Dodds, Anthony J. Gill, Michael Back, David Veivers, Thomas Eade

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Prolonged pemetrexed pretreatment augments persistence of cisplatin-induced DNA damage and eliminates resistant lung cancer stem-like cells associated with EMT

Colin Charles Tièche, Ren-Wang Peng, Patrick Dorn, Laurène Froment, Ralph Alexander Schmid, Thomas Michael Marti

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Combination of metformin and 5-aminosalicylic acid cooperates to decrease proliferation and induce apoptosis in colorectal cancer cell lines

Mona M. Saber, May A. Galal, Afaf A. Ain-Shoka, Samia A. Shouman

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

CXCR4-SDF-1 interaction potentially mediates trafficking of circulating tumor cells in primary breast cancer

M. Mego, D. Cholujova, G. Minarik, T. Sedlackova, P. Gronesova, M. Karaba, J. Benca, S. Cingelova, Z. Cierna, D. Manasova, D. Pindak, J. Sufliarsky, M. Cristofanilli, J. M. Reuben, J. Mardiak

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Prognostic value of the bone scan index using a computer-aided diagnosis system for bone scans in hormone-naive prostate cancer patients with bone metastases

Yasuhide Miyoshi, Shuko Yoneyama, Takashi Kawahara, Yusuke Hattori, Jun-ichi Teranishi, Keiichi Kondo, Masatoshi Moriyama, Shigeo Takebayashi, Yumiko Yokomizo, Masahiro Yao, Hiroji Uemura, Kazumi Noguchi

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Stage of breast cancer at diagnosis in New Zealand: impacts of socio-demographic factors, breast cancer screening and biology

Sanjeewa Seneviratne, Ross Lawrenson, Vernon Harvey, Reena Ramsaroop, Mark Elwood, Nina Scott, Diana Sarfati, Ian Campbell

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Pancreatic panniculitis in a patient with pancreatic-type acinar cell carcinoma of the liver – case report and review of literature

Sebastian Zundler, Ramona Erber, Abbas Agaimy, Arndt Hartmann, Franklin Kiesewetter, Deike Strobel, Markus F. Neurath, Dane Wildner

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

A novel anti-p21Ras scFv antibody reacting specifically with human tumour cell lines and primary tumour tissues

Ju-Lun Yang, Du-Xian Liu, Shi-Jian Zhen, Yun-Gang Zhou, Dai-Jun Zhang, Li-Ying Yang, Hao-Bing Chen, Qiang Feng

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC trial): study protocol for a randomized controlled trial

M. M. Koeneman, A. J. Kruse, L. F. S. Kooreman, A. zur Hausen, A. H. N. Hopman, S. J. S. Sep, T. Van Gorp, B. F. M. Slangen, H. J. van Beekhuizen, M. van de Sande, C. G. Gerestein, H. W. Nijman, R. F. P. M. Kruitwagen

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Associations between metabolic disorders and risk of cancer in Danish men and women – a nationwide cohort study

Siv Mari Berger, Gunnar Gislason, Lynn L. Moore, Charlotte Andersson, Christian Torp-Pedersen, Gerald V. Denis, Michelle Dalgas Schmiegelow

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Transketolase-like 1 ectopic expression is associated with DNA hypomethylation and induces the Warburg effect in melanoma cells

Aparna Jayachandran, Pu-Han Lo, Anderly C. Chueh, Prashanth Prithviraj, Ramyar Molania, Mercedes Davalos-Salas, Matthew Anaka, Marzena Walkiewicz, Jonathan Cebon, Andreas Behren

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Impact on clinical practice of the implementation of guidelines for the toxicity management of targeted therapies in kidney cancer. The protect-2 study

Nuria Lainez, Jesús García-Donas, Emilio Esteban, Javier Puente, M. Isabel Sáez, Enrique Gallardo, Álvaro Pinto-Marín, Sergio Vázquez-Estévez, Luis León, Icíar García-Carbonero, Cristina Suárez-Rodríguez, Carmen Molins, Miguel A. Climent-Duran, Martín Lázaro-Quintela, Aranzazu González del Alba, María José Méndez-Vidal, Isabel Chirivella, Francisco J. Afonso, Marta López-Brea, Nuria Sala-González, Montserrat Domenech, Laura Basterretxea, Carmen Santander-Lobera, Irene Gil-Arnáiz, Ovidio Fernández, Cristina Caballero-Díaz, Begoña Mellado, David Marrupe, José García-Sánchez, Ricardo Sánchez-Escribano, Eva Fernández Parra, José C. Villa Guzmán, Esther Martínez-Ortega, María Belén González, Marina Morán, Beatriz Suarez-Paniagua, María J. Lecumberri, Daniel Castellano

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

METCAM/MUC18 is a novel tumor and metastasis suppressor for the human ovarian cancer SKOV3 cells

Guang-Jer Wu, Guo-fang Zeng

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

A novel and accurate predictor of survival for patients with hepatocellular carcinoma after surgical resection: the neutrophil to lymphocyte ratio (NLR) combined with the aspartate aminotransferase/platelet count ratio index (APRI)

Fei Ji, Yao Liang, Shun-Jun Fu, Zhi-Yong Guo, Man Shu, Shun-Li Shen, Shao-Qiang Li, Bao-Gang Peng, Li-Jian Liang, Yun-Peng Hua

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Prognostic value of ERBB4 expression in patients with triple negative breast cancer

Ji-Yeon Kim, Hae Hyun Jung, In-Gu Do, SooYoun Bae, Se Kyung Lee, Seok Won Kim, Jeong Eon Lee, Seok Jin Nam, Jin Seok Ahn, Yeon Hee Park, Young-Hyuck Im

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Impact of postoperative daily image-guided intensity-modulated radiotherapy on overall and local progression-free survival in patients with oral cavity cancer

Chen-Hsi Hsieh, Pei-Wei Shueng, Li-Ying Wang, Yu-Chuen Huang, Li-Jen Liao, Wu-Chia Lo, Yu-Chin Lin, Le-Jung Wu, Hui-Ju Tien

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Platinum (IV)-fatty acid conjugates overcome inherently and acquired Cisplatin resistant cancer cell lines: an in-vitro study

Einav Ratzon, Yousef Najajreh, Rami Salem, Hazem Khamaisie, Martin Ruthardt, Jamal Mahajna

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

IκBα mediates prostate cancer cell death induced by combinatorial targeting of the androgen receptor

Sarah L. Carter, Margaret M. Centenera, Wayne D. Tilley, Luke A. Selth, Lisa M. Butler

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Forkhead Box F1 promotes breast cancer cell migration by upregulating lysyl oxidase and suppressing Smad2/3 signaling

Gisela Nilsson, Marie Kannius-Janson

01.12.2016 | Technical advance | Ausgabe 1/2016 Open Access

Generation of an algorithm based on minimal gene sets to clinically subtype triple negative breast cancer patients

Brian Z. Ring, David R. Hout, Stephan W. Morris, Kasey Lawrence, Brock L. Schweitzer, Daniel B. Bailey, Brian D. Lehmann, Jennifer A. Pietenpol, Robert S. Seitz

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Intraoperative optical coherence tomography for assessing human lymph nodes for metastatic cancer

Ryan M. Nolan, Steven G. Adie, Marina Marjanovic, Eric J. Chaney, Fredrick A. South, Guillermo L. Monroy, Nathan D. Shemonski, Sarah J. Erickson-Bhatt, Ryan L. Shelton, Andrew J. Bower, Douglas G. Simpson, Kimberly A. Cradock, Z. George Liu, Partha S. Ray, Stephen A. Boppart

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Breast cancer stem cell selectivity of synthetic nanomolar-active salinomycin analogs

Xiaoli Huang, Björn Borgström, Sebastian Kempengren, Lo Persson, Cecilia Hegardt, Daniel Strand, Stina Oredsson

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

RNA disruption is associated with response to multiple classes of chemotherapy drugs in tumor cell lines

Rashmi Narendrula, Kyle Mispel-Beyer, Baoqing Guo, Amadeo M. Parissenti, Laura B. Pritzker, Ken Pritzker, Twinkle Masilamani, Xiaohui Wang, Carita Lannér

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Efficacy and safety of afatinib in Chinese patients with EGFR-mutated metastatic non-small-cell lung cancer (NSCLC) previously responsive to first-generation tyrosine-kinase inhibitors (TKI) and chemotherapy: comparison with historical cohort using erlotinib

Victor H. F. Lee, Dennis K. C. Leung, Tim-Shing Choy, Ka-On Lam, Pui-Mei Lam, To-Wai Leung, Dora L. W. Kwong

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

KSHV gB associated RGD interactions promote attachment of cells by inhibiting the potential migratory signals induced by the disintegrin-like domain

Hosni A. M. Hussein, Lia R. Walker, Shaw M. Akula

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Distribution and prognosis of uncommon metastases from non-small cell lung cancer

Fei-Yu Niu, Qing Zhou, Jin-Ji Yang, Wen-Zhao Zhong, Zhi-Hong Chen, Wei Deng, Yan-Yan He, Hua-Jun Chen, Zhu Zeng, E-E Ke, Ning Zhao, Na Zhang, Hui-Wen Sun, Qiu-Yi Zhang, Zhi Xie, Xu-Chao Zhang, Yi-Long Wu

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Cyclopamine tartrate, an inhibitor of Hedgehog signaling, strongly interferes with mitochondrial function and suppresses aerobic respiration in lung cancer cells

Md Maksudul Alam, Sagar Sohoni, Sarada Preeta Kalainayakan, Massoud Garrossian, Li Zhang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Genetic and cellular studies highlight that A Disintegrin and Metalloproteinase 19 is a protective biomarker in human prostate cancer

Gerard Hoyne, Caroline Rudnicka, Qing-Xiang Sang, Mark Roycik, Sarah Howarth, Peter Leedman, Markus Schlaich, Patrick Candy, Vance Matthews

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Molecular association of glucose-6-phosphate isomerase and pyruvate kinase M2 with glyceraldehyde-3-phosphate dehydrogenase in cancer cells

Mahua R. Das, Arup K. Bag, Shekhar Saha, Alok Ghosh, Sumit K. Dey, Provas Das, Chitra Mandal, Subhankar Ray, Saikat Chakrabarti, Manju Ray, Siddhartha S. Jana

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

A phase 1b study of Selumetinib in combination with Cisplatin and Gemcitabine in advanced or metastatic biliary tract cancer: the ABC-04 study

John Bridgewater, Andre Lopes, Sandra Beare, Marian Duggan, Dymphna Lee, Maravic Ricamara, Delyth McEntee, Ajithkumar Sukumaran, Harpreet Wasan, Juan W. Valle

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Evaluation of serum and tissue levels of VAP-1 in colorectal cancer

Stephen T. Ward, Christopher J. Weston, Emma L. Shepherd, Rahul Hejmadi, Tariq Ismail, David H. Adams

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The anti-oxidative transcription factor Nuclear factor E2 related factor-2 (Nrf2) counteracts TGF-β1 mediated growth inhibition of pancreatic ductal epithelial cells -Nrf2 as determinant of pro-tumorigenic functions of TGF-β1

Geeske Genrich, Marcus Kruppa, Lennart Lenk, Ole Helm, Anna Broich, Sandra Freitag-Wolf, Christoph Röcken, Bence Sipos, Heiner Schäfer, Susanne Sebens

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Correlation between S-1 treatment outcome and expression of biomarkers for refractory thymic carcinoma

Yusuke Okuma, Yukio Hosomi, Shingo Miyamoto, Masahiko Shibuya, Tatsuru Okamura, Tsunekazu Hishima

01.12.2016 | Research Article | Ausgabe 1/2016 Open Access

Change in weight and waist circumference and risk of colorectal cancer: results from the Melbourne Collaborative Cohort Study

Amalia Karahalios, Julie A. Simpson, Laura Baglietto, Robert J. MacInnis, Allison M. Hodge, Graham G. Giles, Dallas R. English

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Combined hepatocellular carcinoma and cholangiocarcinoma (biphenotypic) tumors: clinical characteristics, imaging features of contrast-enhanced ultrasound and computed tomography

Rui Li, Dan Yang, Chun-Lin Tang, Ping Cai, Kuan-sheng Ma, Shi-Yi Ding, Xiao-Hang Zhang, De-Yu Guo, Xiao-Chu Yan

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Distribution and features of hematological malignancies in Eastern Morocco: a retrospective multicenter study over 5 years

Mounia Elidrissi Errahhali, Manal Elidrissi Errahhali, Redouane Boulouiz, Meryem Ouarzane, Mohammed Bellaoui

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448

Oluwaseun Adebayo Bamodu, Wen-Chien Huang, Wei-Hwa Lee, Alexander Wu, Liang Shun Wang, Michael Hsiao, Chi-Tai Yeh, Tsu-Yi Chao

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Analytical performance of a bronchial genomic classifier

Zhanzhi Hu, Duncan Whitney, Jessica R. Anderson, Manqiu Cao, Christine Ho, Yoonha Choi, Jing Huang, Robert Frink, Kate Porta Smith, Robert Monroe, Giulia C. Kennedy, P. Sean Walsh

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Treatment and outcome of 32 patients with distant metastases of Hürthle cell thyroid carcinoma: a single-institution experience

Nikola Besic, Andreja Schwarzbartl-Pevec, Barbara Vidergar-Kralj, Tea Crnic, Barbara Gazic, Maja Marolt Music

01.12.2016 | Research Article | Ausgabe 1/2016 Open Access

Differences in predictions of ODE models of tumor growth: a cautionary example

Hope Murphy, Hana Jaafari, Hana M. Dobrovolny

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Effect of vaccination age on cost-effectiveness of human papillomavirus vaccination against cervical cancer in China

Yi-Jun Liu, Qian Zhang, Shang-Ying Hu, Fang-Hui Zhao

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Analysis of functional germline variants in APOBEC3 and driver genes on breast cancer risk in Moroccan study population

Chaymaa Marouf, Stella Göhler, Miguel Inacio Da Silva Filho, Omar Hajji, Kari Hemminki, Sellama Nadifi, Asta Försti

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Randomized phase III trial of APF530 versus palonosetron in the prevention of chemotherapy-induced nausea and vomiting in a subset of patients with breast cancer receiving moderately or highly emetogenic chemotherapy

Ralph Boccia, Erin O’Boyle, William Cooper

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Myeloproliferative neoplasms (MPNs) have a significant impact on patients’ overall health and productivity: the MPN Landmark survey

Ruben Mesa, Carole B. Miller, Maureen Thyne, James Mangan, Sara Goldberger, Salman Fazal, Xiaomei Ma, Wendy Wilson, Dilan C. Paranagama, David G. Dubinski, John Boyle, John O. Mascarenhas

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Vimentin and Ki67 expression in circulating tumour cells derived from castrate-resistant prostate cancer

C. R. Lindsay, S. Le Moulec, F. Billiot, Y. Loriot, M. Ngo-Camus, P. Vielh, K. Fizazi, C. Massard, F. Farace

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Critical weight loss predicts poor prognosis in nasopharyngeal carcinoma

Qi Zeng, Lu-Jun Shen, Xiang Guo, Xin-Ming Guo, Chao-Nan Qian, Pei-Hong Wu

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Clinical application of genomic profiling to find druggable targets for adolescent and young adult (AYA) cancer patients with metastasis

Soojin Cha, Jeongeun Lee, Jong-Yeon Shin, Ji-Yeon Kim, Sung Hoon Sim, Bhumsuk Keam, Tae Min Kim, Dong-Wan Kim, Dae Seog Heo, Se-Hoon Lee, Jong-Il Kim

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

More expression of BDNF associates with lung squamous cell carcinoma and is critical to the proliferation and invasion of lung cancer cells

Si-yang Zhang, Lin-ping Hui, Chun-yan Li, Jian Gao, Ze-shi Cui, Xue-shan Qiu

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Binimetinib inhibits MEK and is effective against neuroblastoma tumor cells with low NF1 expression

Sarah E. Woodfield, Linna Zhang, Kathleen A. Scorsone, Yin Liu, Peter E. Zage

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Cathepsin K induces platelet dysfunction and affects cell signaling in breast cancer - molecularly distinct behavior of cathepsin K in breast cancer

Sheila Siqueira Andrade, Iuri Estrada Gouvea, Mariana Cristina C. Silva, Eloísa Dognani Castro, Cláudia A. A. de Paula, Debora Okamoto, Lilian Oliveira, Giovani Bravin Peres, Tatiana Ottaiano, Gil Facina, Afonso Celso Pinto Nazário, Antonio Hugo J. F. M. Campos, Edgar Julian Paredes-Gamero, Maria Juliano, Ismael D. C. G. da Silva, Maria Luiza V. Oliva, Manoel J. B. C. Girão

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Clinical significance of AGE-RAGE axis in colorectal cancer: associations with glyoxalase-I, adiponectin receptor expression and prognosis

Stratigoula Sakellariou, Paraskevi Fragkou, Georgia Levidou, Antonios N. Gargalionis, Christina Piperi, Georgia Dalagiorgou, Christos Adamopoulos, Angelica Saetta, George Agrogiannis, Irini Theohari, Stavros Sougioultzis, Panagiota Tsioli, Ioannis Karavokyros, Nikolaos Tsavaris, Ioannis D. Kostakis, Adamantia Zizi-Serbetzoglou, Gerasimos P. Vandoros, Efstratios Patsouris, Penelope Korkolopoulou

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

POU5F1/Oct-4 expression in breast cancer tissue is significantly associated with non-sentinel lymph node metastasis

Shouliang Cai, Shugang Geng, Feng Jin, Jisheng Liu, Chang Qu, Bo Chen

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The anti-fibrotic agent pirfenidone synergizes with cisplatin in killing tumor cells and cancer-associated fibroblasts

Melanie Mediavilla-Varela, Kingsley Boateng, David Noyes, Scott J. Antonia

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: IκBα mediates prostate cancer cell death induced by combinatorial targeting of the androgen receptor

Sarah L. Carter, Margaret M. Centenera, Wayne D. Tilley, Luke A. Selth, Lisa M. Butler

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

A pilot study to compare the detection of HPV-16 biomarkers in salivary oral rinses with tumour p16INK4a expression in head and neck squamous cell carcinoma patients

Ryan C. Chai, Yenkai Lim, Ian H. Frazer, Yunxia Wan, Christopher Perry, Lee Jones, Duncan Lambie, Chamindie Punyadeera

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Patterns of failure after use of 18F-FDG PET/CT in integration of extended-field chemo-IMRT and 3D-brachytherapy plannings for advanced cervical cancers with extensive lymph node metastases

Yih-Lin Chung, Cheng-Fang Horng, Pei-Ing Lee, Fong-Lin Chen

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Stroke related to androgen deprivation therapy for prostate cancer: a meta-analysis and systematic review

Fanzheng Meng, Shimiao Zhu, Jinsheng Zhao, Larissa Vados, Lei Wang, Yusheng Zhao, Dan Zhao, Yuanjie Niu

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: Population attributable risks of modifiable reproductive factors for breast and ovarian cancers in Korea

Boyoung Park, Sohee Park, Hai-Rim Shin, Aesun Shin, Yohwan Yeo, Ji-Yeob Choi, Kyu-Won Jung, Byoung-Gie Kim, Yong-Man Kim, Dong-Young Noh, Sei-Hyun Ahn, Jae Weon Kim, Sokbom Kang, Jae Hoon Kim, Tae Jin Kim, Daehee Kang, Keun-Young Yoo, Sue K. Park

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Primary diffuse leptomeningeal gliomatosis as a rare cause of pain in cervical spine

Štefan Sivák, Ema Kantorová, Egon Kurča, Juraj Marcinek, Pavol Slávik, Jozef Michalik, Vladimír Nosáľ

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

A randomised phase II trial of Stereotactic Ablative Fractionated radiotherapy versus Radiosurgery for Oligometastatic Neoplasia to the lung (TROG 13.01 SAFRON II)

Shankar Siva, Tomas Kron, Mathias Bressel, Marion Haas, Tao Mai, Shalini Vinod, Giuseppe Sasso, Wenchang Wong, Hien Le, Thomas Eade, Nicholas Hardcastle, Brent Chesson, Daniel Pham, Morten Høyer, Rebecca Montgomery, David Ball

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

On Predicting lung cancer subtypes using ‘omic’ data from tumor and tumor-adjacent histologically-normal tissue

Arturo López Pineda, Henry Ato Ogoe, Jeya Balaji Balasubramanian, Claudia Rangel Escareño, Shyam Visweswaran, James Gordon Herman, Vanathi Gopalakrishnan

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Neutrophil-to-lymphocyte ratio is a prognostic marker in bladder cancer patients after radical cystectomy

Takashi Kawahara, Kazuhiro Furuya, Manami Nakamura, Kentaro Sakamaki, Kimito Osaka, Hiroki Ito, Yusuke Ito, Koji Izumi, Shinji Ohtake, Yasuhide Miyoshi, Kazuhide Makiyama, Noboru Nakaigawa, Takeharu Yamanaka, Hiroshi Miyamoto, Masahiro Yao, Hiroji Uemura

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Mitogen-activated protein kinase signaling causes malignant melanoma cells to differentially alter extracellular matrix biosynthesis to promote cell survival

Anna Afasizheva, Alexus Devine, Heather Tillman, King Leung Fung, Wilfred D. Vieira, Benjamin H. Blehm, Yorihisa Kotobuki, Ben Busby, Emily I. Chen, Kandice Tanner

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Local iron homeostasis in the breast ductal carcinoma microenvironment

Oriana Marques, Graça Porto, Alexandra Rêma, Fátima Faria, Arnaud Cruz Paula, Maria Gomez-Lazaro, Paula Silva, Berta Martins da Silva, Carlos Lopes

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Intensive care unit prognostic factors in critically ill patients with advanced solid tumors: a 3-year retrospective study

Rui Xia, Donghao Wang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Chronic ethanol feeding promotes azoxymethane and dextran sulfate sodium-induced colonic tumorigenesis potentially by enhancing mucosal inflammation

Pradeep K. Shukla, Kamaljit K. Chaudhry, Hina Mir, Ruchika Gangwar, Nikki Yadav, Bhargavi Manda, Avtar S. Meena, RadhaKrishna Rao

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Patterns of recurrence after selective postoperative radiation therapy for patients with head and neck squamous cell carcinoma

Naoya Murakami, Fumihiko Matsumoto, Seiichi Yoshimoto, Yoshinori Ito, Taisuke Mori, Takao Ueno, Keisuke Tuchida, Tairo Kashihara, Kazuma Kobayashi, Ken Harada, Mayuka Kitaguchi, Shuhei Sekii, Rei Umezawa, Kana Takahashi, Koji Inaba, Hiroshi Igaki, Jun Itami

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Targeting Rad50 sensitizes human nasopharyngeal carcinoma cells to radiotherapy

Lihong Chang, Jiancong Huang, Kai Wang, Jingjia Li, Ruicheng Yan, Ling Zhu, Jin Ye, Xifu Wu, Shimin Zhuang, Daqing Li, Gehua Zhang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Anti-vascular effects of the cytosolic phospholipase A2 inhibitor AVX235 in a patient-derived basal-like breast cancer model

Eugene Kim, Hanna Maja Tunset, Jana Cebulla, Riyas Vettukattil, Heidi Helgesen, Astrid Jullumstrø Feuerherm, Olav Engebråten, Gunhild Mari Mælandsmo, Berit Johansen, Siver Andreas Moestue

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

The efficacy of iodine-125 permanent brachytherapy versus intensity-modulated radiation for inoperable salivary gland malignancies: study protocol of a randomised controlled trial

Shu-Ming Liu, Hai-Bo Wang, Yan Sun, Yan Shi, Jie Zhang, Ming-Wei Huang, Lei Zheng, Xiao-Ming Lv, Bao-Min Zheng, Kathleen H. Reilly, Xiao-Yan Yan, Ping Ji, Yang-feng Wu, Jian-Guo Zhang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Snail heterogeneity in clear cell renal cell carcinoma

Laura Zaldumbide, Asier Erramuzpe, Rosa Guarch, Rafael Pulido, Jesús M. Cortés, José I. López

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Characterization of various cell lines from different ampullary cancer subtypes and cancer associated fibroblast-mediated responses

Zon Weng Lai, Louisa Bolm, Hannah Fuellgraf, Martin L. Biniossek, Frank Makowiec, Ulrich Theodor Hopt, Martin Werner, Tobias Keck, Dirk Bausch, Claudio Sorio, Aldo Scarpa, Oliver Schilling, Peter Bronsert, Ulrich Friedrich Wellner

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Birth rates among male cancer survivors and mortality rates among their offspring: a population-based study from Sweden

Siau-Wei Tang, Jenny Liu, Lester Juay, Kamila Czene, Hui Miao, Agus Salim, Helena M Verkooijen, Mikael Hartman

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Prognostic factors affecting the risk of thoracic progression in extensive-stage small cell lung cancer

Tomoya Fukui, Michiko Itabashi, Mikiko Ishihara, Yasuhiro Hiyoshi, Masashi Kasajima, Satoshi Igawa, Jiichiro Sasaki, Noriyuki Masuda

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Chronic myeloid leukemia incidence, survival and accessibility of tyrosine kinase inhibitors: a report from population-based Lithuanian haematological disease registry 2000–2013

Tumas Beinortas, Ilma Tavorienė, Tadas Žvirblis, Rolandas Gerbutavičius, Mindaugas Jurgutis, Laimonas Griškevičius

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

GMP-grade α-TEA lysine salt: a 28-Day oral toxicity and toxicokinetic study with a 28-Day recovery period in Beagle dogs

Bella S. Guerrouahen, Tobias Hahn, Zefora Alderman, Brendan Curti, Walter Urba, Emmanuel T. Akporiaye

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Improving gastric cancer preclinical studies using diverse in vitro and in vivo model systems

Hae Ryung Chang, Hee Seo Park, Young Zoo Ahn, Seungyoon Nam, Hae Rim Jung, Sungjin Park, Sang Jin Lee, Curt Balch, Garth Powis, Ja-Lok Ku, Yon Hui Kim

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

miRNA profiling, detection of BRAF V600E mutation and RET-PTC1 translocation in patients from Novosibirsk oblast (Russia) with different types of thyroid tumors

Sergei E. Titov, Mikhail K. Ivanov, Elena V. Karpinskaya, Elena V. Tsivlikova, Sergei P. Shevchenko, Yulia A. Veryaskina, Larisa G. Akhmerova, Tatiana L. Poloz, Olesya A. Klimova, Lyudmila F. Gulyaeva, Igor F. Zhimulev, Nikolay N. Kolesnikov

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

Testing the effects of narrative and play on physical activity among breast cancer survivors using mobile apps: study protocol for a randomized controlled trial

Elizabeth J. Lyons, Tom Baranowski, Karen M. Basen-Engquist, Zakkoyya H. Lewis, Maria C. Swartz, Kristofer Jennings, Elena Volpi

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Cerebral infarction in advanced non-small cell lung cancer: a case control study

Motoyasu Kato, Takehito Shukuya, Keita Mori, Ryota Kanemaru, Yuichiro Honma, Yuta Nanjo, Keiko Muraki, Rina Shibayama, Ryo Koyama, Naoko Shimada, Fumiyuki Takahashi, Kazuhisa Takahashi

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Aggressive breast cancer in western Kenya has early onset, high proliferation, and immune cell infiltration

Rispah T. Sawe, Maggie Kerper, Sunil Badve, Jun Li, Mayra Sandoval-Cooper, Jingmeng Xie, Zonggao Shi, Kirtika Patel, David Chumba, Ayub Ofulla, Jenifer Prosperi, Katherine Taylor, M. Sharon Stack, Simeon Mining, Laurie E. Littlepage

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Dynamic modulation of phosphoprotein expression in ovarian cancer xenograft models

Antonis Koussounadis, Simon P. Langdon, Inhwa Um, Charlene Kay, Kyle E. Francis, David J. Harrison, V. Anne Smith

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Expression of F-actin-capping protein subunit beta, CAPZB, is associated with cell growth and motility in epithelioid sarcoma

Kenta Mukaihara, Yoshiyuki Suehara, Shinji Kohsaka, Daisuke Kubota, Midori Toda-Ishii, Keisuke Akaike, Tsutomu Fujimura, Eisuke Kobayashi, Takashi Yao, Marc Ladanyi, Kazuo Kaneko, Tsuyoshi Saito

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Role of autophagy-related protein expression in patients with rectal cancer treated with neoadjuvant chemoradiotherapy

Byoung Yong Shim, Der Sheng Sun, Hye Sung Won, Myung Ah Lee, Soon Uk Hong, Ji-Han Jung, Hyeon-Min Cho, Yoon Ho Ko

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Urgent surgery after emergency presentation for colorectal cancer has no impact on overall and disease-free survival: a propensity score analysis

Benjamin Weixler, Rene Warschkow, Michaela Ramser, Raoul Droeser, Urs von Holzen, Daniel Oertli, Christoph Kettelhack

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The effect of visceral obesity on clinicopathological features in patients with endometrial cancer: a retrospective analysis of 200 Chinese patients

Shuang Ye, Hao Wen, Zhaoxia Jiang, Xiaohua Wu

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Mutational status of synchronous and metachronous tumor samples in patients with metastatic non-small-cell lung cancer

Gilles Quéré, Renaud Descourt, Gilles Robinet, Sandrine Autret, Odile Raguenes, Brigitte Fercot, Pierre Alemany, Arnaud Uguen, Claude Férec, Isabelle Quintin-Roué, Gérald Le Gac

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

A genetic variant of the NTCP gene is associated with HBV infection status in a Chinese population

Jingmin Yang, Yuan Yang, Mingying Xia, Lianghui Wang, Weiping Zhou, Yajun Yang, Yueming Jiang, Hongyang Wang, Ji Qian, Li Jin, Xiaofeng Wang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Association between alcohol intake and the risk of pancreatic cancer: a dose–response meta-analysis of cohort studies

Ye-Tao Wang, Ya-Wen Gou, Wen-Wen Jin, Mei Xiao, Hua-Ying Fang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Copy number of the Adenomatous Polyposis Coli gene is not always neutral in sporadic colorectal cancers with loss of heterozygosity for the gene

Peter Zauber, Stephen Marotta, Marlene Sabbath-Solitare

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Dynamic changes of alkaline phosphatase are strongly associated with PSA-decline and predict best clinical benefit earlier than PSA-changes under therapy with abiraterone acetate in bone metastatic castration resistant prostate cancer

Phillip Mikah, Laura-Maria Krabbe, Okyaz Eminaga, Edwin Herrmann, Philipp Papavassilis, Reemt Hinkelammert, Axel Semjonow, Andres-Jan Schrader, Martin Boegemann

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Relevance of miR-21 in regulation of tumor suppressor gene PTEN in human cervical cancer cells

Oscar Peralta-Zaragoza, Jessica Deas, Angélica Meneses-Acosta, Faustino De la O-Gómez, Gloria Fernández-Tilapa, Claudia Gómez-Cerón, Odelia Benítez-Boijseauneau, Ana Burguete-García, Kirvis Torres-Poveda, Victor Hugo Bermúdez-Morales, Vicente Madrid-Marina, Mauricio Rodríguez-Dorantes, Alfredo Hidalgo-Miranda, Carlos Pérez-Plasencia

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Evaluation of the role of remission status in a heterogeneous limited disease small-cell lung cancer patient cohort treated with definitive chemoradiotherapy

Farkhad Manapov, Maximilian Niyazi, Sabine Gerum, Olarn Roengvoraphoj, Chukwuka Eze, Minglun Li, Guido Hildebrandt, Rainer Fietkau, Gunther Klautke, Claus Belka

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Efficacy and safety of Vinflunine for advanced or metastatic urothelial carcinoma in routine practice based on the French multi-centre CURVE study

Jacques Médioni, Mario Di Palma, Aline Guillot, Dominique Spaeth, Christine Théodore

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

MiR-29c regulates the expression of miR-34c and miR-449a by targeting DNA methyltransferase 3a and 3b in nasopharyngeal carcinoma

Man Niu, Dan Gao, Qiuyuan Wen, Pingpin Wei, Suming Pan, Cijun Shuai, Huiling Ma, Juanjuan Xiang, Zheng Li, Songqing Fan, Guiyuan Li, Shuping Peng

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Different Array CGH profiles within hereditary breast cancer tumors associated to BRCA1 expression and overall survival

Carolina Alvarez, Andrés Aravena, Teresa Tapia, Ester Rozenblum, Luisa Solís, Alejandro Corvalán, Mauricio Camus, Manuel Alvarez, David Munroe, Alejandro Maass, Pilar Carvallo

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Folic acid tagged nanoceria as a novel therapeutic agent in ovarian cancer

Miriana Hijaz, Soumen Das, Ismail Mert, Ankur Gupta, Zaid Al-Wahab, Calvin Tebbe, Sajad Dar, Jasdeep Chhina, Shailendra Giri, Adnan Munkarah, Sudipta Seal, Ramandeep Rattan

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Self-sampling in cervical cancer screening: comparison of a brush-based and a lavage-based cervicovaginal self-sampling device

Liisa Karjalainen, Ahti Anttila, Pekka Nieminen, Tapio Luostarinen, Anni Virtanen

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors

Ko Sato, Satoshi Watanabe, Aya Ohtsubo, Satoshi Shoji, Daisuke Ishikawa, Tomohiro Tanaka, Koichiro Nozaki, Rie Kondo, Masaaki Okajima, Satoru Miura, Junta Tanaka, Takuro Sakagami, Toshiyuki Koya, Hiroshi Kagamu, Hirohisa Yoshizawa, Ichiei Narita

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Elevated ratio of MMP2/MMP9 activity is associated with poor response to chemotherapy in osteosarcoma

Pierre Kunz, Heiner Sähr, Burkhard Lehner, Christian Fischer, Elisabeth Seebach, Jörg Fellenberg

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Correlation between EGFR gene mutation, cytologic tumor markers, 18F-FDG uptake in non-small cell lung cancer

Arthur Cho, Jin Hur, Yong Wha Moon, Sae Rom Hong, Young Joo Suh, Yun Jung Kim, Dong Jin Im, Yoo Jin Hong, Hye-Jeong Lee, Young Jin Kim, Hyo Sup Shim, Jae Seok Lee, Joo-Hang Kim, Byoung Wook Choi

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

GFRA3 promoter methylation may be associated with decreased postoperative survival in gastric cancer

Lars Lohne Eftang, Jovana Klajic, Vessela N. Kristensen, Jörg Tost, Qin Ying Esbensen, Gustav Peter Blom, Ida Rashida Khan Bukholm, Geir Bukholm

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Epigenetic silencing of miR-181c by DNA methylation in glioblastoma cell lines

Erandi Ayala-Ortega, Rodrigo Arzate-Mejía, Rosario Pérez-Molina, Edgar González-Buendía, Karin Meier, Georgina Guerrero, Félix Recillas-Targa

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Epithelial cell adhesion molecule in human hepatocellular carcinoma cell lines: a target of chemoresistence

Yan Li, Russell W. Farmer, Yingbin Yang, Robert C. G. Martin

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Runs of homozygosity and inbreeding in thyroid cancer

Hauke Thomsen, Bowang Chen, Gisella Figlioli, Rossella Elisei, Cristina Romei, Monica Cipollini, Alfonso Cristaudo, Franco Bambi, Per Hoffmann, Stefan Herms, Stefano Landi, Kari Hemminki, Federica Gemignani, Asta Försti

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Nuclear expression of Lyn, a Src family kinase member, is associated with poor prognosis in renal cancer patients

Antonia K. Roseweir, Tahir Qayyum, Zhi Lim, Rachel Hammond, Alasdair I. MacDonald, Sioban Fraser, Grenville M. Oades, Michael Aitchison, Robert J. Jones, Joanne Edwards

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Clinical significance of the expression of autophagy-associated marker, beclin 1, in breast cancer patients who received neoadjuvant endocrine therapy

Takayuki Ueno, Shigehira Saji, Masahiro Sugimoto, Norikazu Masuda, Katsumasa Kuroi, Nobuaki Sato, Hiroyuki Takei, Yutaka Yamamoto, Shinji Ohno, Hiroko Yamashita, Kazufumi Hisamatsu, Kenjiro Aogi, Hiroji Iwata, Shigeru Imoto, Hironobu Sasano, Masakazu Toi

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Biochemical markers of bone turnover in patients with spinal metastases after resistance training under radiotherapy – a randomized trial

Harald Rief, Georg Omlor, Michael Akbar, Thomas Bruckner, Stefan Rieken, Robert Förster, Ingmar Schlampp, Thomas Welzel, Tilman Bostel, Heinz Jürgen Roth, Jürgen Debus

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Radical nephrectomy and regional lymph node dissection for locally advanced type 2 papillary renal cell carcinoma in an at-risk individual from a family with hereditary leiomyomatosis and renal cell cancer: a case report

Takao Kamai, Hideyuki Abe, Kyoko Arai, Satoshi Murakami, Setsu Sakamoto, Yasushi Kaji, Ken-Ichiro Yoshida

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Herpes simplex virus-1 encephalitis induced by chemoradiotherapy and steroids in an esophageal cancer patient: a case report

Masaaki Saito, Hirokazu Kiyozaki, Tamotu Obitsu, Hirofumi Imoto, Yusuke Taniyama, Osamu Takata, Toshiki Rikiyama

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Randomised controlled trial of a home-based physical activity intervention in breast cancer survivors

Ian M. Lahart, George S. Metsios, Alan M. Nevill, George D. Kitas, Amtul R. Carmichael

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Front-line intraperitoneal versus intravenous chemotherapy in stage III-IV epithelial ovarian, tubal, and peritoneal cancer with minimal residual disease: a competing risk analysis

Yen-Hou Chang, Wai-Hou Li, Yi Chang, Chia-Wen Peng, Ching-Hsuan Cheng, Wei-Pin Chang, Chi-Mu Chuang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Snail-induced epithelial-to-mesenchymal transition of MCF-7 breast cancer cells: systems analysis of molecular changes and their effect on radiation and drug sensitivity

Roman Mezencev, Lilya V. Matyunina, Neda Jabbari, John F. McDonald

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Pursuing equity in cancer care: implementation, challenges and preliminary findings of a public cancer referral center in rural Rwanda

Neo M. Tapela, Tharcisse Mpunga, Bethany Hedt-Gauthier, Molly Moore, Egide Mpanumusingo, Mary Jue Xu, Ignace Nzayisenga, Vedaste Hategekimana, Denis Gilbert Umuhizi, Lydia E. Pace, Jean Bosco Bigirimana, JingJing Wang, Caitlin Driscoll, Frank R. Uwizeye, Peter C. Drobac, Gedeon Ngoga, Cyprien Shyirambere, Clemence Muhayimana, Leslie Lehmann, Lawrence N. Shulman

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

RETRACTED ARTICLE: CDK4 and miR-15a comprise an abnormal automodulatory feedback loop stimulating the pathogenesis and inducing chemotherapy resistance in nasopharyngeal carcinoma

Zhen Liu, Chao Cheng, Xiaojun Luo, Qiong Xia, Yejie Zhang, Xiaobing Long, Qingping Jiang, Weiyi Fang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Apoptosis-induced ectodomain shedding of hypoxia-regulated carbonic anhydrase IX from tumor cells: a double-edged response to chemotherapy

Ivana Vidlickova, Franck Dequiedt, Lenka Jelenska, Olga Sedlakova, Michal Pastorek, Stanislav Stuchlik, Jaromir Pastorek, Miriam Zatovicova, Silvia Pastorekova

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

TNF-alpha promotes lymphangiogenesis and lymphatic metastasis of gallbladder cancer through the ERK1/2/AP-1/VEGF-D pathway

HaiJie Hong, Lei Jiang, YanFei Lin, CaiLong He, GuangWei Zhu, Qiang Du, XiaoQian Wang, FeiFei She, YanLing Chen

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Diagnostic values of serum cathepsin B and D in patients with nasopharyngeal carcinoma

Gongjun Tan, Qianxu Liu, Xiaowei Tang, Ting Kang, Yuejin Li, Jinping Lu, Xiaoming Zhao, Faqing Tang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Hair dye use, regular exercise, and the risk and prognosis of prostate cancer: multicenter case–control and case-only studies

Shu-Yu Tai, Hui-Min Hsieh, Shu-Pin Huang, Ming-Tsang Wu

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Severe myositis of the hip flexors after pre-operative chemoradiation therapy for locally advanced rectal cancer: case report

Matthew M. Florczynski, Michael S. Sanatani, Lauren Mai, Barbara Fisher, Dwight E. Moulin, Jeffrey Cao, Alexander V. Louie, Janet E. Pope, Eric Leung

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The prognostic value of rectal invasion for stage IVA uterine cervical cancer treated with radiation therapy

Masaru Wakatsuki, Shingo Kato, Hiroki Kiyohara, Tatsuya Ohno, Kumiko Karasawa, Tomoaki Tamaki, Ken Ando, Shintaro Shiba, Tadashi Kamada, Takashi Nakano

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Honokiol inhibits sphere formation and xenograft growth of oral cancer side population cells accompanied with JAK/STAT signaling pathway suppression and apoptosis induction

Jhy-Shrian Huang, Chih-Jung Yao, Shuang-En Chuang, Chi-Tai Yeh, Liang-Ming Lee, Ruei-Ming Chen, Wan-Ju Chao, Jacqueline Whang-Peng, Gi-Ming Lai

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The milk-derived fusion peptide, ACFP, suppresses the growth of primary human ovarian cancer cells by regulating apoptotic gene expression and signaling pathways

Juan Zhou, Mengjing Zhao, Yigui Tang, Jing Wang, Cai Wei, Fang Gu, Ting Lei, Zhiwu Chen, Yide Qin

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Oral proteasome inhibitor with strong preclinical efficacy in myeloma models

Jonghoon Park, Eok Park, Cheol-Kyu Jung, Seung-Wan Kang, Byung Gyu Kim, Youngjoo Jung, Tae Hun Kim, Ji-Young Lim, Sung-Eun Lee, Chang-Ki Min, Kwang-Ai Won

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Comparison of clinical outcomes between luminal invasive ductal carcinoma and luminal invasive lobular carcinoma

Yayoi Adachi, Junko Ishiguro, Haruru Kotani, Tomoka Hisada, Mari Ichikawa, Naomi Gondo, Akiyo Yoshimura, Naoto Kondo, Masaya Hattori, Masataka Sawaki, Takashi Fujita, Toyone Kikumori, Yasushi Yatabe, Yasuhiro Kodera, Hiroji Iwata

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The prognostic value of lactate dehydrogenase levels in colorectal cancer: a meta-analysis

Guanghua Li, Zhao Wang, Jianbo Xu, Hui Wu, Shirong Cai, Yulong He

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

At least two well-spaced samples are needed to genotype a solid tumor

Kimberly Siegmund, Darryl Shibata

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Antitumor effects of cecropin B-LHRH’ on drug-resistant ovarian and endometrial cancer cells

Xiaoyong Li, Bo Shen, Qi Chen, Xiaohui Zhang, Yiqing Ye, Fengmei Wang, Xinmei Zhang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Mmu-miR-125b overexpression suppresses NO production in activated macrophages by targeting eEF2K and CCNA2

Zhenbiao Xu, Lianmei Zhao, Xin Yang, Sisi Ma, Yehua Ge, Yanxin Liu, Shilian Liu, Juan Shi, Dexian Zheng

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Down-regulation of S100A9 inhibits osteosarcoma cell growth through inactivating MAPK and NF-κB signaling pathways

Si Cheng, Xi Zhang, Ning Huang, Quanhe Qiu, Ying Jin, Dianming Jiang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Response to post-axitinib treatment in patients with metastatic renal cell carcinoma

Namita Chittoria, Housam Haddad, Paul Elson, Nizar M. Tannir, Laura S. Wood, Robert Dreicer, Jorge A. Garcia, Brian I. Rini, Eric Jonasch

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Cervical and breast cancer screening participation for women with chronic conditions in France: results from a national health survey

Panayotis Constantinou, Rosemary Dray-Spira, Gwenn Menvielle

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

CYP1A2 – a novel genetic marker for early aromatase inhibitor response in the treatment of breast cancer patients

Maria Simonsson, Srinivas Veerla, Andrea Markkula, Carsten Rose, Christian Ingvar, Helena Jernström

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Nemo-like kinase as a negative regulator of nuclear receptor Nurr1 gene transcription in prostate cancer

Jian Wang, Zhi-Hong Yang, Hua Chen, Hua-Hui Li, Li-Yong Chen, Zhu Zhu, Ying Zou, Cong-Cong Ding, Jing Yang, Zhi-Wei He

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

What surgeons tell patients and what patients want to know before major cancer surgery: a qualitative study

Angus G. K. McNair, F MacKichan, J. L. Donovan, S. T. Brookes, K. N. L. Avery, S. M. Griffin, T. Crosby, J. M. Blazeby

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Planar cell polarity gene expression correlates with tumor cell viability and prognostic outcome in neuroblastoma

Cecilia Dyberg, Panagiotis Papachristou, Bjørn Helge Haug, Hugo Lagercrantz, Per Kogner, Thomas Ringstedt, Malin Wickström, John Inge Johnsen

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Systematic review: brain metastases from colorectal cancer—Incidence and patient characteristics

Troels Dreier Christensen, Karen-Lise Garm Spindler, Jesper Andreas Palshof, Dorte Lisbet Nielsen

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Verification of microRNA expression in human endometrial adenocarcinoma

Sanja Jurcevic, Karin Klinga-Levan, Björn Olsson, Katarina Ejeskär

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

Benchmarking trial between France and Australia comparing management of primary rectal cancer beyond TME and locally recurrent rectal cancer (PelviCare Trial): rationale and design

Quentin Denost, Florence Saillour, Lindy Masya, Helene Maillou Martinaud, Stephanie Guillon, Marion Kret, Eric Rullier, Bruno Quintard, Michael Solomon

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

In vitro and in vivo activity of melflufen (J1) in lymphoma

Maryam Delforoush, Sara Strese, Malin Wickström, Rolf Larsson, Gunilla Enblad, Joachim Gullbo

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

Advance care planning – a multi-centre cluster randomised clinical trial: the research protocol of the ACTION study

Judith A. C. Rietjens, Ida J. Korfage, Lesley Dunleavy, Nancy J. Preston, Lea J. Jabbarian, Caroline Arnfeldt Christensen, Maja de Brito, Francesco Bulli, Glenys Caswell, Branka Červ, Johannes van Delden, Luc Deliens, Giuseppe Gorini, Mogens Groenvold, Dirk Houttekier, Francesca Ingravallo, Marijke C. Kars, Urška Lunder, Guido Miccinesi, Alenka Mimić, Eugenio Paci, Sheila Payne, Suzanne Polinder, Kristian Pollock, Jane Seymour, Anja Simonič, Anna Thit Johnsen, Mariëtte N. Verkissen, Esther de Vries, Andrew Wilcock, Marieke Zwakman, Agnes van der Heide (Pl)

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Randomized phase III trial of amrubicin/cisplatin versus etoposide/cisplatin as first-line treatment for extensive small-cell lung cancer

Yan Sun, Ying Cheng, Xuezhi Hao, Jie Wang, Chengping Hu, Baohui Han, Xiaoqing Liu, Li Zhang, Huiping Wan, Zhongjun Xia, Yunpeng Liu, Wei Li, Mei Hou, Helong Zhang, Qingyu Xiu, Yunzhong Zhu, Jifeng Feng, Shukui Qin, Xiaoyan Luo

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

A phase II study of Endostatin in combination with paclitaxel, carboplatin, and radiotherapy in patients with unresectable locally advanced non-small cell lung cancer

Xiao-Jiang Sun, Qing-Hua Deng, Xin-Min Yu, Yong-Lin Ji, Yuan-Da Zheng, Hao Jiang, Ya-Ping Xu, Sheng-Lin Ma

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Minimal renal toxicity after Rituximab DHAP with a modified cisplatin application scheme in patients with relapsed or refractory diffuse large B-cell lymphoma

K. Lisenko, F. McClanahan, T. Schöning, M. A. Schwarzbich, M. Cremer, T. Dittrich, A. D. Ho, M. Witzens-Harig

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Establishment and characterization of new cell lines of anaplastic pancreatic cancer, which is a rare malignancy: OCUP-A1 and OCUP-A2

Kotaro Miura, Kenjiro Kimura, Ryosuke Amano, Sadaaki Yamazoe, Go Ohira, Akihiro Murata, Kohei Nishio, Tsuyoshi Hasegawa, Masakazu Yashiro, Bunzo Nakata, Masaichi Ohira, Kosei Hirakawa

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Prognostic impact of IKZF1 deletion in adults with common B-cell acute lymphoblastic leukemia

Qiu-Mei Yao, Kai-Yan Liu, Robert Peter Gale, Bin Jiang, Yan-Rong Liu, Qian Jiang, Hao Jiang, Xiao-Hui Zhang, Mei-Jie Zhang, Shan-Shan Chen, Xiao-Jun Huang, Lan-Ping Xu, Guo-Rui Ruan

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Treatment with anti-IL-6 receptor antibody prevented increase in serum hepcidin levels and improved anemia in mice inoculated with IL-6–producing lung carcinoma cells

Mariko Noguchi-Sasaki, Yusuke Sasaki, Yasushi Shimonaka, Kazushige Mori, Kaori Fujimoto-Ouchi

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Comparative analysis of copy number variations in ulcerative colitis associated and sporadic colorectal neoplasia

B. M. Shivakumar, Sanjiban Chakrabarty, Harish Rotti, Venu Seenappa, Lakshmi Rao, Vasudevan Geetha, B. V. Tantry, Hema Kini, Rajesh Dharamsi, C. Ganesh Pai, Kapaettu Satyamoorthy

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: Correlation between S-1 treatment outcome and expression of biomarkers for refractory thymic carcinoma

Yusuke Okuma, Yukio Hosomi, Shingo Miyamoto, Masahiko Shibuya, Tatsuru Okamura, Tsunekazu Hishima

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Short-term culture of tumour slices reveals the heterogeneous sensitivity of human head and neck squamous cell carcinoma to targeted therapies

Jérôme Donnadieu, Emma Lachaier, Marine Peria, Zuzana Saidak, Stéphanie Dakpe, Jean-Fortune Ikoli, Bruno Chauffert, Cyril Page, Antoine Galmiche

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Identification of stromal ColXα1 and tumor-infiltrating lymphocytes as putative predictive markers of neoadjuvant therapy in estrogen receptor-positive/HER2-positive breast cancer

Alexander S. Brodsky, Jinjun Xiong, Dongfang Yang, Christoph Schorl, Mary Anne Fenton, Theresa A. Graves, William M. Sikov, Murray B. Resnick, Yihong Wang

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: Generation of an algorithm based on minimal gene sets to clinically subtype triple negative breast cancer patients

Brian Z. Ring, David R. Hout, Stephan W. Morris, Kasey Lawrence, Brock L. Schweitzer, Daniel B. Bailey, Brian D. Lehmann, Jennifer A. Pietenpol, Robert S. Seitz

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Survivin protein expression is involved in the progression of non-small cell lung cancer in Asians: a meta-analysis

Liang Duan, Xuefei Hu, Yuxing Jin, Ruijun Liu, Qingjun You

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Improvement of ablative margins by the intraoperative use of CEUS-CT/MR image fusion in hepatocellular carcinoma

Kai Li, Zhong-Zhen Su, Er-Jiao Xu, Jin-Xiu Ju, Xiao-Chun Meng, Rong-Qin Zheng

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

A phase Ia/Ib clinical trial of metronomic chemotherapy based on a mathematical model of oral vinorelbine in metastatic non-small cell lung cancer and malignant pleural mesothelioma: rationale and study protocol

Xavier Elharrar, Dominique Barbolosi, Joseph Ciccolini, Christophe Meille, Christian Faivre, Bruno Lacarelle, Nicolas André, Fabrice Barlesi

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Selective activation of TNFR1 and NF-κB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells

Christiana G. Savva, Sotirios Totokotsopoulos, Kyriakos C. Nicolaou, Christiana M. Neophytou, Andreas I. Constantinou

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Gemcitabine and docetaxel in relapsed and unresectable high-grade osteosarcoma and spindle cell sarcoma of bone

E. Palmerini, R. L. Jones, E. Marchesi, A. Paioli, M. Cesari, A. Longhi, C. Meazza, L. Coccoli, F. Fagioli, S. Asaftei, G. Grignani, A. Tamburini, S. M. Pollack, P. Picci, S. Ferrari

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

The Lung Screen Uptake Trial (LSUT): protocol for a randomised controlled demonstration lung cancer screening pilot testing a targeted invitation strategy for high risk and ‘hard-to-reach’ patients

Samantha L. Quaife, Mamta Ruparel, Rebecca J. Beeken, Andy McEwen, John Isitt, Gary Nolan, Karen Sennett, David R. Baldwin, Stephen W. Duffy, Samuel M. Janes, Jane Wardle

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

High-dose chemotherapy and autologous stem cell transplant compared with conventional chemotherapy for consolidation in newly diagnosed primary CNS lymphoma—a randomized phase III trial (MATRix)

Elisabeth Schorb, Juergen Finke, Andrés J. M. Ferreri, Gabriele Ihorst, Kristina Mikesch, Benjamin Kasenda, Kristina Fritsch, Heidi Fricker, Elvira Burger, Olga Grishina, Elke Valk, Emanuele Zucca, Gerald Illerhaus

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Alcohol-related breast cancer in postmenopausal women – effect of CYP19A1, PPARG and PPARGC1A polymorphisms on female sex-hormone levels and interaction with alcohol consumption and NSAID usage in a nested case-control study and a randomised controlled trial

Tine Iskov Kopp, Ditte Marie Jensen, Gitte Ravn-Haren, Arieh Cohen, Helle Molgaard Sommer, Lars Ove Dragsted, Anne Tjonneland, David Michael Hougaard, Ulla Vogel

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Cancer incidence in urban Shanghai, 1973-2010: an updated trend and age-period-cohort effects

Ping-Ping Bao, Ying Zheng, Chun-Xiao Wu, Zhe-Zhou Huang, Yu-Tang Gao, Fan Jin, Yong-Bing Xiang, Wei-Jian Zhong, Wei Lu, Fan Wu

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Relevance of internal time and circadian robustness for cancer patients

Elisabet Ortiz-Tudela, Pasquale F. Innominato, Maria Angeles Rol, Francis Lévi, Juan Antonio Madrid

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Basal metabolic state governs AIF-dependent growth support in pancreatic cancer cells

Andrew J. Scott, Amanda S. Wilkinson, John C. Wilkinson

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Chemotherapy for intracranial ependymoma in adults

Dorothee Gramatzki, Patrick Roth, Jörg Felsberg, Silvia Hofer, Elisabeth J. Rushing, Bettina Hentschel, Manfred Westphal, Dietmar Krex, Matthias Simon, Oliver Schnell, Wolfgang Wick, Guido Reifenberger, Michael Weller

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Accelerated hypofractionated three-dimensional conformal radiation therapy (3 Gy/fraction) combined with concurrent chemotherapy for patients with unresectable stage III non-small cell lung cancer: preliminary results of an early terminated phase II trial

Xiao-Cang Ren, Quan-Yu Wang, Rui Zhang, Xue-Ji Chen, Na Wang, Yue-E Liu, Jie Zong, Zhi-Jun Guo, Dong-Ying Wang, Qiang Lin

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Lung cancer treatment and mortality for Aboriginal people in New South Wales, Australia: results from a population-based record linkage study and medical record audit

Alison Gibberd, Rajah Supramaniam, Anthony Dillon, Bruce K. Armstrong, Dianne L. O’Connell

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

Rationale and design of the German-Speaking Myeloma Multicenter Group (GMMG) trial ReLApsE: a randomized, open, multicenter phase III trial of lenalidomide/dexamethasone versus lenalidomide/dexamethasone plus subsequent autologous stem cell transplantation and lenalidomide maintenance in patients with relapsed multiple myeloma

Marc-Andrea Baertsch, Jana Schlenzka, Elias K. Mai, Maximilian Merz, Jens Hillengaß, Marc S. Raab, Dirk Hose, Patrick Wuchter, Anthony D. Ho, Anna Jauch, Thomas Hielscher, Christina Kunz, Steffen Luntz, Stefan Klein, Ingo G. H. Schmidt-Wolf, Martin Goerner, Martin Schmidt-Hieber, Peter Reimer, Ullrich Graeven, Roland Fenk, Hans Salwender, Christof Scheid, Axel Nogai, Mathias Haenel, Hans W. Lindemann, Hans Martin, Richard Noppeney, Katja Weisel, Hartmut Goldschmidt

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

Protocol of a randomized controlled trial of the fear of recurrence therapy (FORT) intervention for women with breast or gynecological cancer

Christine Maheu, Sophie Lebel, Christine Courbasson, Monique Lefebvre, Mina Singh, Lori J. Bernstein, Linda Muraca, Aronela Benea, Lynne Jolicoeur, Cheryl Harris, Agnihotram V. Ramanakumar, Sarah Ferguson, Souraya Sidani

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

A predictive tool particularly designed for elderly myeloma patients presenting with spinal cord compression

Dirk Rades, Antonio Jose Conde-Moreno, Jon Cacicedo, Theo Veninga, Niklas Gebauer, Tobias Bartscht, Steven E. Schild

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Risks of developing breast and colorectal cancer in association with incomes and geographic locations in Texas: a retrospective cohort study

Zheyu Liu, Kai Zhang, Xianglin L. Du

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The occurrence of non-melanoma malignant skin lesions and non-cutaneous squamous-cell carcinoma among metastatic melanoma patients: an observational cohort study in Denmark

Haojie Li, Lars Pedersen, Mette Nørgaard, Sinna P. Ulrichsen, Sandra K. Thygesen, Jeanenne J. Nelson

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

After low and high dose-rate interstitial brachytherapy followed by IMRT radiotherapy for intermediate and high risk prostate cancer

Satoshi Nakamura, Naoya Murakami, Koji Inaba, Akihisa Wakita, Kazuma Kobayashi, Kana Takahashi, Hiroyuki Okamoto, Rei Umezawa, Madoka Morota, Minako Sumi, Hiroshi Igaki, Yoshinori Ito, Jun Itami

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Expression of the cereblon binding protein argonaute 2 plays an important role for multiple myeloma cell growth and survival

Qinqin Xu, Yue-xian Hou, Paul Langlais, Patrick Erickson, James Zhu, Chang-Xin Shi, Moulun Luo, Yuanxiao Zhu, Ye Xu, Lawrence J. Mandarino, Keith Stewart, Xiu-bao Chang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Genetic polymorphism rs3760396 of the chemokine (C-C motif) ligand 2 gene (CCL2) associated with the susceptibility of lung cancer in a pathological subtype-specific manner in Han-ancestry Chinese: a case control study

Xu Li, Fangcai Lin, Hong Zhou

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

Focal vs extended ablation in localized prostate cancer with irreversible electroporation; a multi-center randomized controlled trial

Matthijs J. V. Scheltema, Willemien van den Bos, Daniel M. de Bruin, Hessel Wijkstra, M. Pilar Laguna, Theo M. de Reijke, Jean JMCH de la Rosette

01.12.2016 | Technical advance | Ausgabe 1/2016 Open Access

A cell transportation solution that preserves live circulating tumor cells in patient blood samples

Steingrimur Stefansson, Daniel L. Adams, William B. Ershler, Huyen Le, David H. Ho

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Follow-up practices for high-grade extremity Osteosarcoma

Christian Rothermundt, Beatrice M. Seddon, Palma Dileo, Sandra J. Strauss, Joanne Coleman, Timothy W. Briggs, Sarah R. Haile, Jeremy S. Whelan

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

MEK5 overexpression is associated with the occurrence and development of colorectal cancer

Dechang Diao, Lei Wang, Jin Wan, Zhiqiang Chen, Junsheng Peng, Huanliang Liu, Xinlin Chen, Wei Wang, Liaonan Zou

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

Design of a multicentre randomized controlled trial to evaluate the effectiveness of a tailored clinical support intervention to enhance return to work for gastrointestinal cancer patients

AnneClaire G.N.M. Zaman, Kristien M.A.J. Tytgat, Jean H.G. Klinkenbijl, Monique H.W. Frings-Dresen, Angela G.E.M. de Boer

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Profound reduction in tamoxifen active metabolite endoxifen in a breast cancer patient treated with rifampin prior to initiation of an anti-TNFα biologic for ulcerative colitis: a case report

Sara L. Henderson, Wendy A. Teft, Richard B. Kim

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Enhancement of the CXCL12/CXCR4 axis due to acquisition of gemcitabine resistance in pancreatic cancer: effect of CXCR4 antagonists

Mamoru Morimoto, Yoichi Matsuo, Shuji Koide, Ken Tsuboi, Tomoya Shamoto, Takafumi Sato, Kenta Saito, Hiroki Takahashi, Hiromitsu Takeyama

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Feasibility study of first-line chemotherapy using Pemetrexed and Bevacizumab for advanced or recurrent nonsquamous non-small cell lung cancer in elderly patients: TORG1015

Toshiyuki Kozuki, Naoyuki Nogami, Hiromoto Kitajima, Shunichiro Iwasawa, Emiko Sakaida, Yuichi Takiguchi, Satoshi Ikeda, Masahiro Yoshida, Terufumi Kato, Shingo Miyamoto, Kentaro Sakamaki, Tetsu Shinkai, Koshiro Watanabe

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Evaluation of clinical parameters influencing the development of bone metastasis in breast cancer

Joachim Diessner, Manfred Wischnewsky, Tanja Stüber, Roland Stein, Mathias Krockenberger, Sebastian Häusler, Wolfgang Janni, Rolf Kreienberg, Maria Blettner, Lukas Schwentner, Achim Wöckel, Catharina Bartmann

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Tyrosine kinase inhibitor SU11274 increased tumorigenicity and enriched for melanoma-initiating cells by bioenergetic modulation

Lucia Kucerova, Lucia Demkova, Svetlana Skolekova, Roman Bohovic, Miroslava Matuskova

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Heme oxygenase is not involved in the anti-proliferative effects of statins on pancreatic cancer cells

K. Vanova, S. Boukalova, H. Gbelcova, L. Muchova, J. Neuzil, R. Gurlich, T. Ruml, L. Vitek

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet

Danielle M. Lussier, Eric C. Woolf, John L. Johnson, Kenneth S. Brooks, Joseph N. Blattman, Adrienne C. Scheck

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Smoking-related cancer in military veterans: retrospective cohort study of 57,000 veterans and 173,000 matched non-veterans

Beverly P. Bergman, Daniel F. Mackay, David Morrison, Jill P. Pell

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Combinatory effect of BRCA1 and HERC2 expression on outcome in advanced non-small-cell lung cancer

Laura Bonanno, Carlota Costa, Margarita Majem, Jose-Javier Sanchez, Ignacio Rodriguez, Ana Gimenez-Capitan, Miquel Angel Molina-Vila, Alain Vergnenegre, Bartomeu Massuti, Adolfo Favaretto, Massimo Rugge, Cinta Pallares, Miquel Taron, Rafael Rosell

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Decreased expression of hyaluronan synthase 1 and 2 associates with poor prognosis in cutaneous melanoma

Mari Poukka, Andrey Bykachev, Hanna Siiskonen, Kristiina Tyynelä-Korhonen, Päivi Auvinen, Sanna Pasonen-Seppänen, Reijo Sironen

01.12.2016 | Review | Ausgabe 1/2016 Open Access

The non-genomic loss of function of tumor suppressors: an essential role in the pathogenesis of chronic myeloid leukemia chronic phase

Sabrina Crivellaro, Giovanna Carrà, Cristina Panuzzo, Riccardo Taulli, Angelo Guerrasio, Giuseppe Saglio, Alessandro Morotti

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

MicroRNA-663a is downregulated in non-small cell lung cancer and inhibits proliferation and invasion by targeting JunD

Yi Zhang, Xiaoman Xu, Meng Zhang, Xin Wang, Xue Bai, Hui Li, Liang Kan, Yong Zhou, Huiyan Niu, Ping He

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Epigenetically maintained SW13+ and SW13- subtypes have different oncogenic potential and convert with HDAC1 inhibition

McKale R. Davis, Juliane J. Daggett, Agnes S. Pascual, Jessica M. Lam, Kathryn J. Leyva, Kimbal E. Cooper, Elizabeth E. Hull

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Protein expression changes induced in a malignant melanoma cell line by the curcumin analogue compound D6

Marina Pisano, Antonio Palomba, Alessandro Tanca, Daniela Pagnozzi, Sergio Uzzau, Maria Filippa Addis, Maria Antonietta Dettori, Davide Fabbri, Giuseppe Palmieri, Carla Rozzo

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

Preoperative chemoradiation with paclitaxel-carboplatin or with fluorouracil-oxaliplatin—folinic acid (FOLFOX) for resectable esophageal and junctional cancer: the PROTECT-1402, randomized phase 2 trial

Mathieu Messager, Xavier Mirabel, Emmanuelle Tresch, Amaury Paumier, Véronique Vendrely, Laetitia Dahan, Olivier Glehen, Frederique Vasseur, Thomas Lacornerie, Guillaume Piessen, Farid El Hajbi, William B. Robb, Stéphanie Clisant, Andrew Kramar, Christophe Mariette, Antoine Adenis

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

The role of the addition of ovarian suppression to tamoxifen in young women with hormone-sensitive breast cancer who remain premenopausal or regain menstruation after chemotherapy (ASTRRA): study protocol for a randomized controlled trial and progress

Hyun-Ah Kim, Sei Hyun Ahn, Seok Jin Nam, Seho Park, Jungsil Ro, Seock-Ah Im, Yong Sik Jung, Jung Han Yoon, Min Hee Hur, Yoon Ji Choi, Soo-Jung Lee, Joon Jeong, Se-Heon Cho, Sung Yong Kim, Min Hyuk Lee, Lee Su Kim, Byung-In Moon, Tae Hyun Kim, Chanheun Park, Sei Joong Kim, Sung Hoo Jung, Heungkyu Park, Geum Hee Gwak, Sun Hee Kang, Jong Gin Kim, Jeryong Kim, Su Yun Choi, Cheol-Wan Lim, Doyil Kim, Youngbum Yoo, Young-Jin Song, Yoon-Jung Kang, Sang Seol Jung, Hyuk Jai Shin, Kwan Ju Lee, Se-Hwan Han, Eun Sook Lee, Wonshik Han, Hee-Jung Kim, Woo Chul Noh

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Pretreatment neutrophil-to-lymphocyte ratio is correlated with response to neoadjuvant chemotherapy as an independent prognostic indicator in breast cancer patients: a retrospective study

Yi Chen, Kai Chen, Xiaoyun Xiao, Yan Nie, Shaohua Qu, Chang Gong, Fengxi Su, Erwei Song

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Helicobacter pylori promotes angiogenesis depending on Wnt/beta-catenin-mediated vascular endothelial growth factor via the cyclooxygenase-2 pathway in gastric cancer

Ningning Liu, Ning Zhou, Ni Chai, Xuan Liu, Haili Jiang, Qiong Wu, Qi Li

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Influence of mTOR-inhibitors and mycophenolic acid on human cholangiocellular carcinoma and cancer associated fibroblasts

Nils Heits, Tillmann Heinze, Alexander Bernsmeier, Jannik Kerber, Charlotte Hauser, Thomas Becker, Holger Kalthoff, Jan-Hendrik Egberts, Felix Braun

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

Continuous intraoperative monitoring of pelvic autonomic nerves during TME to prevent urogenital and anorectal dysfunction in rectal cancer patients (NEUROS): a randomized controlled trial

D. W. Kauff, K Kronfeld, S Gorbulev, D Wachtlin, H Lang, W Kneist

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

An uncommon manifestation of paraneoplastic cerebellar degeneration in a patient with high grade urothelial, carcinoma with squamous differentiation: A case report and literature review

Yaofeng Zhu, Shouzhen Chen, Songyu Chen, Jing Song, Fan Chen, Hu Guo, Zhenhua Shang, Yong Wang, Changkuo Zhou, Benkang Shi

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Transarterial chemoembolization of hepatocellular carcinoma in a rat model: the effect of additional injection of survivin siRNA to the treatment protocol

Thomas J. Vogl, Elsie Oppermann, Jun Qian, Ulli Imlau, Andreas Tran, Yousef Hamidavi, Huedayi Korkusuz, Wolf Otto Bechstein, Nour-Eldin Abdel-Rehim Nour-Eldin, Tatjana Gruber-Rouh, Renate Hammerstingl, Nagy Naguib Naeem Naguib

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Progesterone receptor blockade in human breast cancer cells decreases cell cycle progression through G2/M by repressing G2/M genes

Susan E. Clare, Akash Gupta, MiRan Choi, Manish Ranjan, Oukseub Lee, Jun Wang, David Z. Ivancic, J. Julie Kim, Seema A. Khan

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Primary tumor site is a useful predictor of cetuximab efficacy in the third-line or salvage treatment of KRAS wild-type (exon 2 non-mutant) metastatic colorectal cancer: a nationwide cohort study

Kuo-Hsing Chen, Yu-Yun Shao, Ho-Min Chen, Yu-Lin Lin, Zhong-Zhe Lin, Mei-Shu Lai, Ann-Lii Cheng, Kun-Huei Yeh

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Activated thrombin-activatable fibrinolysis inhibitor (TAFIa) attenuates breast cancer cell metastatic behaviors through inhibition of plasminogen activation and extracellular proteolysis

Zainab A. Bazzi, Danielle Lanoue, Mouhanned El-Youssef, Rocco Romagnuolo, Janice Tubman, Dora Cavallo-Medved, Lisa A. Porter, Michael B. Boffa

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Platelet to lymphocyte ratio as an independent prognostic indicator for prostate cancer patients receiving androgen deprivation therapy

Yanqing Wang, Fan Xu, Jiahua Pan, Yinjie Zhu, Xiaoguang Shao, Jianjun Sha, Zezhou Wang, Yong Cai, Qiang Liu, Baijun Dong, Wei Xue, Yiran Huang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Risk allelic load in Th2 and Th3 cytokines genes as biomarker of susceptibility to HPV-16 positive cervical cancer: a case control study

K. Torres-Poveda, A. I. Burguete-García, M. Bahena-Román, R. Méndez-Martínez, M. A. Zurita-Díaz, G. López-Estrada, K. Delgado-Romero, O. Peralta-Zaragoza, V. H. Bermúdez-Morales, D. Cantú, A. García-Carrancá, V. Madrid-Marina

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The effect of soluble E-selectin on tumor progression and metastasis

Shin-Ae Kang, Celine A. Blache, Sandra Bajana, Nafis Hasan, Mohamed Kamal, Yoshihiro Morita, Vineet Gupta, Bilegtsaikhan Tsolmon, K. Stephen Suh, David G. Gorenstein, Wajeeha Razaq, Hallgeir Rui, Takemi Tanaka

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Corepressive function of nuclear receptor coactivator 2 in androgen receptor of prostate cancer cells treated with antiandrogen

Keisuke Takeda, Noboru Hara, Tsutomu Nishiyama, Masayuki Tasaki, Fumio Ishizaki, Yoshihiko Tomita

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Characterisation of the DNA sequence specificity, cellular toxicity and cross-linking properties of novel bispyridine-based dinuclear platinum complexes

Ben W. Johnson, Vincent Murray, Mark D. Temple

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Importance of hereditary and selected environmental risk factors in the etiology of inflammatory breast cancer: a case-comparison study

Roxana Moslehi, Elizabeth Freedman, Nur Zeinomar, Carmela Veneroso, Paul H. Levine

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor

Sarah Daakour, Leon Juvenal Hajingabo, Despoina Kerselidou, Aurelie Devresse, Richard Kettmann, Nicolas Simonis, Franck Dequiedt, Jean-Claude Twizere

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Selective mode of action of plumbagin through BRCA1 deficient breast cancer stem cells

Veena Somasundaram, Sreelatha K Hemalatha, Krishnendu Pal, Sutapa Sinha, Asha S. Nair, Debabrata Mukhopadhyay, Priya Srinivas

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

SLCO1B1*5 polymorphism (rs4149056) is associated with chemotherapy-induced amenorrhea in premenopausal women with breast cancer: a prospective cohort study

Toralf Reimer, Sarah Kempert, Bernd Gerber, Hans-Jürgen Thiesen, Steffi Hartmann, Dirk Koczan

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Potential efficacy of therapies targeting intrahepatic lesions after sorafenib treatment of patients with hepatocellular carcinoma

Takeshi Terashima, Tatsuya Yamashita, Rika Horii, Kuniaki Arai, Kazunori Kawaguchi, Kazuya Kitamura, Taro Yamashita, Yoshio Sakai, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

ICECREAM: randomised phase II study of cetuximab alone or in combination with irinotecan in patients with metastatic colorectal cancer with either KRAS, NRAS, BRAF and PI3KCA wild type, or G13D mutated tumours

Eva Segelov, Paul Waring, Jayesh Desai, Kate Wilson, Val Gebski, Subotheni Thavaneswaran, Elena Elez, Craig Underhill, Nick Pavlakis, Lorraine Chantrill, Louise Nott, Michael Jefford, Mustafa Khasraw, Fiona Day, Harpreet Wasan, Fortunato Ciardiello, Chris Karapetis, Warren Joubert, Guy van Hazel, Andrew Haydon, Tim Price, Sabine Tejpar, Niall Tebbutt, Jeremy Shapiro

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

Assessment of laparoscopic stomach preserving surgery with sentinel basin dissection versus standard gastrectomy with lymphadenectomy in early gastric cancer–A multicenter randomized phase III clinical trial (SENORITA trial) protocol

Ji Yeon Park, Young-Woo Kim, Keun Won Ryu, Byung-Ho Nam, Young Joon Lee, Sang Ho Jeong, Ji-Ho Park, Hoon Hur, Sang-Uk Han, Jae Seok Min, Ji Yeong An, Woo Jin Hyung, Gyu Seok Cho, Gui Ae Jeong, Oh Jeong, Young Kyu Park, Mi Ran Jung, Hong Man Yoon, Bang Wool Eom

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Cross-talk between the Tissue Factor/coagulation factor VIIa complex and the tyrosine kinase receptor EphA2 in cancer

Oskar Eriksson, Åsa Thulin, Anna Asplund, Geeta Hegde, Sanjay Navani, Agneta Siegbahn

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Absence of an association of human polyomavirus and papillomavirus infection with lung cancer in China: a nested case–control study

Danny V. Colombara, Lisa E. Manhart, Joseph J. Carter, Stephen E. Hawes, Noel S. Weiss, James P. Hughes, You-Lin Qiao, Philip R. Taylor, Jennifer S. Smith, Denise A. Galloway

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

L-Arginine supplementation inhibits the growth of breast cancer by enhancing innate and adaptive immune responses mediated by suppression of MDSCs in vivo

Yu Cao, Yonghui Feng, Yanjun Zhang, Xiaotong Zhu, Feng Jin

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Economic evaluation of the breast cancer screening programme in the Basque Country: retrospective cost-effectiveness and budget impact analysis

Arantzazu Arrospide, Montserrat Rue, Nicolien T. van Ravesteyn, Merce Comas, Myriam Soto-Gordoa, Garbiñe Sarriugarte, Javier Mar

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

3D culture of Her2+ breast cancer cells promotes AKT to MAPK switching and a loss of therapeutic response

Sharath Gangadhara, Chris Smith, Peter Barrett-Lee, Stephen Hiscox

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Ultrasound screening for cholangiocarcinoma could detect premalignant lesions and early-stage diseases with survival benefits: a population-based prospective study of 4,225 subjects in an endemic area

Prakongboon Sungkasubun, Surachate Siripongsakun, Kunlayanee Akkarachinorate, Sirachat Vidhyarkorn, Akeanong Worakitsitisatorn, Thaniya Sricharunrat, Sutida Singharuksa, Rawisak Chanwat, Chairat Bunchaliew, Sirima Charoenphattharaphesat, Ruechuta Molek, Maneenop Yimyaem, Gaidganok Sornsamdang, Kamonwan Soonklang, Kasiruck Wittayasak, Chirayu U. Auewarakul, Chulabhorn Mahidol

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Clinical characteristics and prognosis of 272 postterm choriocarcinoma patients at Peking Union Medical College Hospital: a retrospective cohort study

Jie Li, Junjun Yang, Pengfei Liu, Tong Ren, Jun Zhao, Fengzhi Feng, Xirun Wan, Yang Xiang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Long-term outcomes in radically treated synchronous vs. metachronous oligometastatic non-small-cell lung cancer

Jochen Fleckenstein, Alev Petroff, Hans-Joachim Schäfers, Thomas Wehler, Jakob Schöpe, Christian Rübe

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice

J. R. Hens, I. Sinha, F. Perodin, T. Cooper, R. Sinha, J. Plummer, C. E. Perrone, D. Orentreich

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

High-risk oral leukoplakia is associated with aberrant promoter methylation of multiple genes

Masanobu Abe, Satoshi Yamashita, Yoshiyuki Mori, Takahiro Abe, Hideto Saijo, Kazuto Hoshi, Toshikazu Ushijima, Tsuyoshi Takato

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Prediction of non-muscle invasive bladder cancer outcomes assessed by innovative multimarker prognostic models

E. López de Maturana, A. Picornell, A. Masson-Lecomte, M. Kogevinas, M. Márquez, A. Carrato, A. Tardón, J. Lloreta, M. García-Closas, D. Silverman, N. Rothman, S. Chanock, F. X. Real, M. E. Goddard, N. Malats, On behalf of the SBC/EPICURO Study Investigators

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

HERMIONE: a randomized Phase 2 trial of MM-302 plus trastuzumab versus chemotherapy of physician’s choice plus trastuzumab in patients with previously treated, anthracycline-naïve, HER2-positive, locally advanced/metastatic breast cancer

Kathy Miller, Javier Cortes, Sara A. Hurvitz, Ian E. Krop, Debu Tripathy, Sunil Verma, Kaveh Riahi, Joseph G. Reynolds, Thomas J. Wickham, Istvan Molnar, Denise A. Yardley

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

A functional microRNA library screen reveals miR-410 as a novel anti-apoptotic regulator of cholangiocarcinoma

Tiziana Palumbo, George A. Poultsides, Grigorios Kouraklis, Theodore Liakakos, Alexandra Drakaki, George Peros, Maria Hatziapostolou, Dimitrios Iliopoulos

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Epidermal growth factor signals regulate dihydropyrimidine dehydrogenase expression in EGFR-mutated non-small-cell lung cancer

Tetsuro Tominaga, Tomoshi Tsuchiya, Koji Mochinaga, Junichi Arai, Naoya Yamasaki, Keitaro Matsumoto, Takuro Miyazaki, Toshiya Nagasaki, Atsushi Nanashima, Kazuhiro Tsukamoto, Takeshi Nagayasu

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Time course decomposition of cell heterogeneity in TFEB signaling states reveals homeostatic mechanisms restricting the magnitude and duration of TFEB responses to mTOR activity modulation

Paula Andrea Marin Zapata, Carsten Jörn Beese, Anja Jünger, Giovanni Dalmasso, Nathan Ryan Brady, Anne Hamacher-Brady

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Factors influencing diagnosis delay of advanced breast cancer in Moroccan women

A. Maghous, F. Rais, S. Ahid, N. Benhmidou, K. Bellahamou, H. Loughlimi, E. Marnouche, S. Elmajjaoui, H. Elkacemi, T. Kebdani, N. Benjaafar

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Patients with hepatic breast cancer metastases demonstrate highly specific profiles of matrix metalloproteinases MMP-2 and MMP-9 after SIRT treatment as compared to other primary and secondary liver tumours

Olga Golubnitschaja, Kristina Yeghiazaryan, Helena Stricker, Daniela Trog, Hans H. Schild, Leonard Berliner

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Comparative expression patterns and diagnostic efficacies of SR splicing factors and HNRNPA1 in gastric and colorectal cancer

Won Cheol Park, Hak-Ryul Kim, Dong Baek Kang, Jae-Suk Ryu, Keum-Ha Choi, Gyeong-Ok Lee, Ki Jung Yun, Keun Young Kim, Raekil Park, Kwon-Ha Yoon, Ji-Hyun Cho, Young-Jin Lee, Soo-Cheon Chae, Min-Cheol Park, Do-Sim Park

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Osteopontin regulates proliferation, apoptosis, and migration of murine claudin-low mammary tumor cells

S. Saleh, D. E. Thompson, J. McConkey, P. Murray, R. A. Moorehead

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Safety and feasibility of fasting in combination with platinum-based chemotherapy

Tanya B. Dorff, Susan Groshen, Agustin Garcia, Manali Shah, Denice Tsao-Wei, Huyen Pham, Chia-Wei Cheng, Sebastian Brandhorst, Pinchas Cohen, Min Wei, Valter Longo, David I. Quinn

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Stimulation of triple negative breast cancer cell migration and metastases formation is prevented by chloroquine in a pre-irradiated mouse model

Gina Bouchard, Hélène Therriault, Sameh Geha, Yves Bérubé-Lauzière, Rachel Bujold, Caroline Saucier, Benoit Paquette

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Can advanced new radiation therapy technologies improve outcome of high grade glioma (HGG) patients? analysis of 3D-conformal radiotherapy (3DCRT) versus volumetric-modulated arc therapy (VMAT) in patients treated with surgery, concomitant and adjuvant chemo-radiotherapy

Pierina Navarria, Federico Pessina, Luca Cozzi, Anna Maria Ascolese, Francesca Lobefalo, Antonella Stravato, Giuseppe D’Agostino, Ciro Franzese, Manuela Caroli, Lorenzo Bello, Marta Scorsetti

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

MYC and BCL2 overexpression is associated with a higher class of Memorial Sloan-Kettering Cancer Center prognostic model and poor clinical outcome in primary diffuse large B-cell lymphoma of the central nervous system

Sehui Kim, Soo Jeong Nam, Dohee Kwon, Hannah Kim, Eunyoung Lee, Tae Min Kim, Dae Seog Heo, Sung Hye Park, Chul Woo Kim, Yoon Kyung Jeon

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Variation in use of targeted therapies for metastatic renal cell carcinoma: Results from a Dutch population-based registry

S. De Groot, S. Sleijfer, W. K. Redekop, E. Oosterwijk, J. B. A. G. Haanen, L. A. L. M. Kiemeney, C. A. Uyl-de Groot

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Unusual association of non-anaplastic Wilms tumor and Cornelia de Lange syndrome: case report

Claudia Santoro, Andrea Apicella, Fiorina Casale, Angela La Manna, Martina Di Martino, Daniela Di Pinto, Cristiana Indolfi, Silverio Perrotta

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

PTEN mRNA expression is less pronounced in left- than right-sided colon cancer: a retrospective observational study

Hidekazu Kuramochi, Ayako Nakamura, Go Nakajima, Yuka Kaneko, Tatsuo Araida, Masakazu Yamamoto, Kazuhiko Hayashi

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Molecular analyses of unselected head and neck cancer cases demonstrates that human papillomavirus transcriptional activity is positively associated with survival and prognosis

Liam Masterson, David M. Winder, Siolian L. R. Ball, Katie Vaughan, Martin Lehmann, Lars-Uwe Scholtz, Jane C. Sterling, Holger H. Sudhoff, Peter K. C. Goon

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

A comparison of 12-gene colon cancer assay gene expression in African American and Caucasian patients with stage II colon cancer

Rangaswamy Govindarajan, James Posey, Calvin Y. Chao, Ruixiao Lu, Trafina Jadhav, Ahmed Y. Javed, Awais Javed, Fade A. Mahmoud, Raymond U. Osarogiagbon, Upender Manne

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: A phase 1b study of Selumetinib in combination with Cisplatin and Gemcitabine in advanced or metastatic biliary tract cancer: the ABC-04 study

John Bridgewater, Andre Lopes, Sandra Beare, Marian Duggan, Dymphna Lee, Maravic Ricamara, Delyth McEntee, Ajithkumar Sukumaran, Harpreet Wasan, Juan W. Valle

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: The effect of soluble E-selectin on tumor progression and metastasis

Shin-Ae Kang, Celine A. Blache, Sandra Bajana, Nafis Hasan, Mohamed Kamal, Yoshihiro Morita, Vineet Gupta, Bilegtsaikhan Tsolmon, K. Stephen Suh, David G. Gorenstein, Wajeeha Razaq, Hallgeir Rui, Takemi Tanaka

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Tissue metabolic profiling of human gastric cancer assessed by 1H NMR

Huijuan Wang, Hailong Zhang, Pengchi Deng, Chunqi Liu, Dandan Li, Hui Jie, Hu Zhang, Zongguang Zhou, Ying-Lan Zhao

01.12.2016 | Debate | Ausgabe 1/2016 Open Access

Debate: adjuvant whole brain radiotherapy or not? More data is the wiser choice

Gerald B. Fogarty, Angela Hong, Vinai Gondi, Bryan Burmeister, Kari Jacobsen, Serigne Lo, Elizabeth Paton, Brindha Shivalingam, John F. Thompson

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Prognostic significance of p53 expression in patients with esophageal cancer: a meta-analysis

Lianghai Wang, Xiaodan Yu, Jing Li, Zhiyu Zhang, Jun Hou, Feng Li

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses vasculogenic mimicry and proliferation of highly aggressive pancreatic cancer PaTu8988 cells

Xing-dong Xu, Lan Yang, Li-yun Zheng, Yan-yan Pan, Zhi-fei Cao, Zhi-qing Zhang, Quan-sheng Zhou, Bo Yang, Cong Cao

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Long-term survival and BRCA status in male breast cancer: a retrospective single-center analysis

Piera Gargiulo, Matilde Pensabene, Monica Milano, Grazia Arpino, Mario Giuliano, Valeria Forestieri, Caterina Condello, Rossella Lauria, Sabino De Placido

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Context dependent regulatory patterns of the androgen receptor and androgen receptor target genes

Jan Roger Olsen, Waqas Azeem, Margrete Reime Hellem, Kristo Marvyin, Yaping Hua, Yi Qu, Lisha Li, Biaoyang Lin, XI-Song Ke, Anne Margrete Øyan, Karl-Henning Kalland

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Systematic drug screening reveals specific vulnerabilities and co-resistance patterns in endocrine-resistant breast cancer

Sara Kangaspeska, Susanne Hultsch, Alok Jaiswal, Henrik Edgren, John-Patrick Mpindi, Samuli Eldfors, Oscar Brück, Tero Aittokallio, Olli Kallioniemi

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Suppression of cell migration is promoted by miR-944 through targeting of SIAH1 and PTP4A1 in breast cancer cells

Ali Flores-Pérez, Laurence A. Marchat, Sergio Rodríguez-Cuevas, Verónica Piña Bautista, Lizeth Fuentes-Mera, Diana Romero-Zamora, Anabel Maciel-Dominguez, Olga Hernández de la Cruz, Miguel Fonseca-Sánchez, Erika Ruíz-García, Horacio Astudillo-de la Vega, César López-Camarillo

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Transanal total mesorectal excision (taTME) for rectal cancer: a systematic review and meta-analysis of oncological and perioperative outcomes compared with laparoscopic total mesorectal excision

Bin Ma, Peng Gao, Yongxi Song, Cong Zhang, Changwang Zhang, Longyi Wang, Hongpeng Liu, Zhenning Wang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Survival rates of cancer patients with and without rheumatic disease: a retrospective cohort analysis

Jin Kyun Park, Ji Ae Yang, Eun Young Ahn, Sung Hae Chang, Yeong Wook Song, Jeffrey R. Curtis, Eun Bong Lee

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Comparison of the miRNA profiles in HPV-positive and HPV-negative tonsillar tumors and a model system of human keratinocyte clones

Zuzana Vojtechova, Ivan Sabol, Martina Salakova, Jana Smahelova, Jiri Zavadil, Lubomir Turek, Marek Grega, Jan Klozar, Bohumir Prochazka, Ruth Tachezy

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Metalloproteases meprin-ɑ (MEP1A) is a prognostic biomarker and promotes proliferation and invasion of colorectal cancer

Xiao Wang, Jian Chen, Jingtao Wang, Fudong Yu, Senlin Zhao, Yu Zhang, Huamei Tang, Zhihai Peng

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Cetuximab-induced aseptic meningitis: case report and review of a rare adverse event

Christophe Maritaz, Carole Metz, Nabil Baba-Hamed, Méryam Jardin-Szucs, Gaël Deplanque

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Bone alkaline phosphatase as a surrogate marker of bone metastasis in gastric cancer patients

Sun Min Lim, Youn Nam Kim, Ki Hyun Park, Beodeul Kang, Hong Jae Chon, Chan Kim, Joo Hoon Kim, Sun Young Rha

01.12.2016 | Debate | Ausgabe 1/2016 Open Access

TAS-102, the first “cardio-gentle” fluoropyrimidine in the colorectal cancer landscape?

Fausto Petrelli, Sandro Barni, Paola Bertocchi, Alberto Zaniboni

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

Lifestyle in Multiple Myeloma - a longitudinal cohort study protocol

M. Heinrich, A. Fisher, B. Paton, O. McCourt, R. J. Beeken, A. Hackshaw, J. Wardle, K. Yong

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

CD80 down-regulation is associated to aberrant DNA methylation in non-inflammatory colon carcinogenesis

Marco Scarpa, Melania Scarpa, Ignazio Castagliuolo, Francesca Erroi, Silvia Basato, Paola Brun, Imerio Angriman, Carlo Castoro

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The use of a multiple imputation method to investigate the trends in Histologic types of lung cancer in Songkhla province, Thailand, 1989–2013

Hutcha Sriplung, Seesai Yeesoonsang, Edward McNeil, Surichai Bilheem

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

A case of lymphangioleiomyomatosis associated with endometrial cancer and severe systemic lupus erythematosus

Kensuke Suzuki, Kazunori Nagasaka, Katsutoshi Oda, Hiroyuki Abe, Daichi Maeda, Yoko Matsumoto, Takahide Arimoto, Kei Kawana, Masashi Fukayama, Yutaka Osuga, Tomoyuki Fujii

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Expansive hematoma in delayed cerebral radiation necrosis in patients treated with T-DM1: a report of two cases

Koichi Mitsuya, Junichiro Watanabe, Yoko Nakasu, Nakamasa Hayashi, Hideyuki Harada, Ichiro Ito

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Use and misuse of common terminology criteria for adverse events in cancer clinical trials

Sheng Zhang, Fei Liang, Ian Tannock

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

GSK-3 directly regulates phospho-4EBP1 in renal cell carcinoma cell-line: an intrinsic subcellular mechanism for resistance to mTORC1 inhibition

Hiromi Ito, Osamu Ichiyanagi, Sei Naito, Vladimir N. Bilim, Yoshihiko Tomita, Tomoyuki Kato, Akira Nagaoka, Norihiko Tsuchiya

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Prognostic and predictive significance of tumor length in patients with esophageal squamous cell carcinoma undergoing radical resection

Jie Wu, Qi-Xun Chen

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Occupational prestige, social mobility and the association with lung cancer in men

Thomas Behrens, Isabelle Groß, Jack Siemiatycki, David I. Conway, Ann Olsson, Isabelle Stücker, Florence Guida, Karl-Heinz Jöckel, Hermann Pohlabeln, Wolfgang Ahrens, Irene Brüske, Heinz-Erich Wichmann, Per Gustavsson, Dario Consonni, Franco Merletti, Lorenzo Richiardi, Lorenzo Simonato, Cristina Fortes, Marie-Elise Parent, John McLaughlin, Paul Demers, Maria Teresa Landi, Neil Caporaso, David Zaridze, Neonila Szeszenia-Dabrowska, Peter Rudnai, Jolanta Lissowska, Eleonora Fabianova, Adonina Tardón, John K. Field, Rodica Stanescu Dumitru, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Hans Kromhout, Roel Vermeulen, Paolo Boffetta, Kurt Straif, Joachim Schüz, Jan Hovanec, Benjamin Kendzia, Beate Pesch, Thomas Brüning

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer

Jun Kasuga, Takashi Kawahara, Daiji Takamoto, Sachi Fukui, Takashi Tokita, Tomoyuki Tadenuma, Masaki Narahara, Syusei Fusayasu, Hideyuki Terao, Koji Izumi, Hiroki Ito, Yusuke Hattori, Jun-ichi Teranishi, Takeshi Sasaki, Kazuhide Makiyama, Yasuhide Miyoshi, Masahiro Yao, Yasushi Yumura, Hiroshi Miyamoto, Hiroji Uemura

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

INFα-2b inhibitory effects on CD4+CD25+FOXP3+ regulatory T cells in the tumor microenvironment of C57BL/6 J mice with melanoma xenografts

Yang Yu, Run Huang, Xiangyun Zong, Xiangming He, Wenju Mo

01.12.2016 | Technical advance | Ausgabe 1/2016 Open Access

Technical validation of an RT-qPCR in vitro diagnostic test system for the determination of breast cancer molecular subtypes by quantification of ERBB2, ESR1, PGR and MKI67 mRNA levels from formalin-fixed paraffin-embedded breast tumor specimens

Mark Laible, Kornelia Schlombs, Katharina Kaiser, Elke Veltrup, Stefanie Herlein, Sotiris Lakis, Robert Stöhr, Sebastian Eidt, Arndt Hartmann, Ralph M. Wirtz, Ugur Sahin

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Epigenetic silencing of serine protease HTRA1 drives polyploidy

Nina Schmidt, Inga Irle, Kamilla Ripkens, Vanda Lux, Jasmin Nelles, Christian Johannes, Lee Parry, Kirsty Greenow, Sarah Amir, Mara Campioni, Alfonso Baldi, Chio Oka, Masashi Kawaichi, Alan R. Clarke, Michael Ehrmann

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Prognostic and clinical impact of PIK3CA mutation in gastric cancer: pyrosequencing technology and literature review

Kazuto Harada, Yoshifumi Baba, Hironobu Shigaki, Takatsugu Ishimoto, Keisuke Miyake, Keisuke Kosumi, Ryuma Tokunaga, Daisuke Izumi, Mayuko Ohuchi, Kenichi Nakamura, Yuki Kiyozumi, Junji Kurashige, Masaaki Iwatsuki, Yuji Miyamoto, Yasuo Sakamoto, Naoya Yoshida, Masayuki Watanabe, Hideo Baba

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Detection of circulating tumor cells using manually performed immunocytochemistry (MICC) does not correlate with outcome in patients with early breast cancer – Results of the German SUCCESS-A- trial

Julia Jueckstock, Brigitte Rack, Thomas W. P. Friedl, Christoph Scholz, Julia Steidl, Elisabeth Trapp, Hans Tesch, Helmut Forstbauer, Ralf Lorenz, Mahdi Rezai, Lothar Häberle, Marianna Alunni-Fabbroni, Andreas Schneeweiss, Matthias W. Beckmann, Werner Lichtenegger, Peter A. Fasching, Klaus Pantel, Wolfgang Janni, for the SUCCESS Study Group

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Pre-diagnostic body mass index and weight change in relation to colorectal cancer survival among incident cases from a population-based cohort study

Ida Laake, Inger K. Larsen, Randi Selmer, Inger Thune, Marit B. Veierød

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Chemotherapy versus radiotherapy for FIGO stages IB1 and IIA1 cervical carcinoma patients with postoperative isolated deep stromal invasion: a retrospective study

Lei Li, XiaoYan Song, RuoNan Liu, Nan Li, Ye Zhang, Yan Cheng, HongTu Chao, LiYing Wang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Eribulin-induced liver dysfunction as a prognostic indicator of survival of metastatic breast cancer patients: a retrospective study

Takayuki Kobayashi, Jyunichi Tomomatsu, Ippei Fukada, Tomoko Shibayama, Natsuki Teruya, Yoshinori Ito, Takuji Iwase, Shinji Ohno, Shunji Takahashi

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

A cost effective analysis of fixed-dose combination of dutasteride and tamsulosin compared with dutasteride monotherapy for benign prostatic hyperplasia in Nigeria: a middle income perspective; using an interactive Markov model

Emeka I. Udeh, Chimaobi G. Ofoha, David A. Adewole, Ikenna I. Nnabugwu

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

EGFR gene amplification is relatively common and associates with outcome in intestinal adenocarcinoma of the stomach, gastro-oesophageal junction and distal oesophagus

Eva-Maria Birkman, Annika Ålgars, Minnamaija Lintunen, Raija Ristamäki, Jari Sundström, Olli Carpén

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Metabolic syndrome is associated with advanced prostate cancer in patients treated with radical retropubic prostatectomy: results from a multicentre prospective study

Cosimo De Nunzio, Giuseppe Simone, Aldo Brassetti, Riccardo Mastroianni, Devis Collura, Giovanni Muto, Michele Gallucci, Andrea Tubaro

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

Psychosocial impact of prognostic genetic testing in the care of uveal melanoma patients: protocol of a controlled prospective clinical observational study

Yesim Erim, Jennifer Scheel, Anja Breidenstein, Claudia HD Metz, Dietmar Lohmann, Hans-Christoph Friederich, Sefik Tagay

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Interleukin-22 is elevated in lavage from patients with lung cancer and other pulmonary diseases

Amanda Tufman, Rudolf Maria Huber, Stefanie Völk, Frederic Aigner, Martin Edelmann, Fernando Gamarra, Rosemarie Kiefl, Kathrin Kahnert, Fei Tian, Anne-Laure Boulesteix, Stefan Endres, Sebastian Kobold

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Clinicopathological and prognostic significance of GPX2 protein expression in esophageal squamous cell carcinoma

Zhijin Lei, Dongping Tian, Chong Zhang, Shukun Zhao, Min Su

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Fluorescent imaging of superficial head and neck squamous cell carcinoma using a γ-glutamyltranspeptidase-activated targeting agent: a pilot study

Takeshi Mizushima, Shunsuke Ohnishi, Yuichi Shimizu, Yutaka Hatanaka, Kanako C. Hatanaka, Hidetaka Hosono, Yoshimasa Kubota, Mitsuteru Natsuizaka, Mako Kamiya, Shouko Ono, Akihiro Homma, Mototsugu Kato, Naoya Sakamoto, Yasuteru Urano

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Survival, safety, and prognostic factors for outcome with Regorafenib in patients with metastatic colorectal cancer refractory to standard therapies: results from a multicenter study (REBECCA) nested within a compassionate use program

Antoine Adenis, Christelle de la Fouchardiere, Bernard Paule, Pascal Burtin, David Tougeron, Jennifer Wallet, Louis-Marie Dourthe, Pierre-Luc Etienne, Laurent Mineur, Stéphanie Clisant, Jean-Marc Phelip, Andrew Kramar, Thierry Andre

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Melanoma-specific mortality and competing mortality in patients with non-metastatic malignant melanoma: a population-based analysis

Weidong Shen, Naoko Sakamoto, Limin Yang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Mammographic density and structural features can individually and jointly contribute to breast cancer risk assessment in mammography screening: a case–control study

Rikke Rass Winkel, My von Euler-Chelpin, Mads Nielsen, Kersten Petersen, Martin Lillholm, Michael Bachmann Nielsen, Elsebeth Lynge, Wei Yao Uldall, Ilse Vejborg

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Tumor-suppressive effects of atelocollagen-conjugated hsa-miR-520d-5p on un-differentiated cancer cells in a mouse xenograft model

Yoshitaka Ishihara, Satoshi Tsuno, Satoshi Kuwamoto, Taro Yamashita, Yusuke Endo, Keigo Miura, Yugo Miura, Takemasa Sato, Junichi Hasegawa, Norimasa Miura

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

ColoNav: patient navigation for colorectal cancer screening in deprived areas – Study protocol

C. Allary, A. Bourmaud, F. Tinquaut, M. Oriol, J. Kalecinski, V. Dutertre, N. Lechopier, M. Pommier, Y. Benoist, S. Rousseau, V. Regnier, V. Buthion, F. Chauvin

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Predictive factors for a long-term response duration in non-squamous cell lung cancer patients treated with pemetrexed

Sojung Park, Hyun Jung Kim, Chang–Min Choi, Dae Ho Lee, Sang–We Kim, Jung–Shin Lee, Woo Sung Kim, Se Hoon Choi, Jin Kyung Rho, Jae Cheol Lee

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Metformin treatment modulates the tumour-induced wasting effects in muscle protein metabolism minimising the cachexia in tumour-bearing rats

André G. Oliveira, Maria Cristina C. Gomes-Marcondes

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Macrophage phenotypic subtypes diametrically regulate epithelial-mesenchymal plasticity in breast cancer cells

Min Yang, Bo Ma, Hanshuang Shao, Amanda M. Clark, Alan Wells

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

A phase I trial of the trifunctional anti Her2 × anti CD3 antibody ertumaxomab in patients with advanced solid tumors

N. Haense, A. Atmaca, C. Pauligk, K. Steinmetz, F. Marmé, G. M. Haag, M. Rieger, O. G. Ottmann, P. Ruf, H. Lindhofer, S.-E. Al-Batran

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Comparing the case mix and survival of women receiving breast cancer care from one private provider with other London women with breast cancer: pilot data exchange and analyses

Elizabeth A. Davies, Victoria H. Coupland, Steve Dixon, Kefah Mokbel, Ruth H. Jack

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Increased toll-like receptors and p53 levels regulate apoptosis and angiogenesis in non-muscle invasive bladder cancer: mechanism of action of P-MAPA biological response modifier

Patrick Vianna Garcia, Fábio Rodrigues Ferreira Seiva, Amanda Pocol Carniato, Wilson de Mello Júnior, Nelson Duran, Alda Maria Macedo, Alexandre Gabarra de Oliveira, Rok Romih, Iseu da Silva Nunes, Odilon da Silva Nunes, Wagner José Fávaro

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Delphinidin-3-glucoside suppresses breast carcinogenesis by inactivating the Akt/HOTAIR signaling pathway

Xiaohong Yang, En Luo, Xin Liu, Bin Han, Xiaoping Yu, Xiaoli Peng

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Optimal staging system for predicting the prognosis of patients with hepatocellular carcinoma in China: a retrospective study

Lihui Su, Tao Zhou, Zongli Zhang, Xiuguo Zhang, Xuting Zhi, Caixia Li, Qingliang Wang, Chongqi Jia, Wenna Shi, Yanqiu Yue, Yanjing Gao, Baoquan Cheng

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The eicosanoids leukotriene D4 and prostaglandin E2 promote the tumorigenicity of colon cancer-initiating cells in a xenograft mouse model

Kishan Bellamkonda, Naveen Kumar Chandrashekar, Janina Osman, Benson Chellakkan Selvanesan, Sayeh Savari, Anita Sjölander

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Increasing incidence of thyroid cancer in the Nordic countries with main focus on Swedish data

Michael Carlberg, Lena Hedendahl, Mikko Ahonen, Tarmo Koppel, Lennart Hardell

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The impact of disease-related symptoms and palliative care concerns on health-related quality of life in multiple myeloma: a multi-centre study

Christina Ramsenthaler, Thomas R. Osborne, Wei Gao, Richard J. Siegert, Polly M. Edmonds, Stephen A. Schey, Irene J. Higginson

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Serum HER2 extra-cellular domain, S100ß and CA 15-3 levels are independent prognostic factors in metastatic breast cancer patients

Amélie Darlix, Pierre-Jean Lamy, Evelyne Lopez-Crapez, Antoine Laurent Braccini, Nelly Firmin, Gilles Romieu, Simon Thezenas, William Jacot

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Efficacy of sorafenib in BRAF-mutated non-small-cell lung cancer (NSCLC) and no response in synchronous BRAF wild type-hepatocellular carcinoma: a case report

Andrea Casadei Gardini, Elisa Chiadini, Luca Faloppi, Giorgia Marisi, Angelo Delmonte, Mario Scartozzi, Cristian Loretelli, Alessandro Lucchesi, Devil Oboldi, Alessandra Dubini, Giovanni Luca Frassineti, Paola Ulivi

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Factors associated with late recurrence after completion of 5-year adjuvant tamoxifen in estrogen receptor positive breast cancer

Eun-Shin Lee, Wonshik Han, Min Kyoon Kim, Jongjin Kim, Tae-kyung Yoo, Moo Hyun Lee, Kyung Hun Lee, Tae Yong Kim, Hyeong-Gon Moon, Seock-Ah Im, Dong-Young Noh, Eun Sook Lee

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Involvement of DNMT 3B promotes epithelial-mesenchymal transition and gene expression profile of invasive head and neck squamous cell carcinomas cell lines

Li-Hsuen Chen, Wen-Lin Hsu, Yen-Ju Tseng, Dai-Wei Liu, Ching-Feng Weng

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Coalition of Oct4A and β1 integrins in facilitating metastasis in ovarian cancer

Chantel Samardzija, Rodney B. Luwor, Michael A. Quinn, George Kannourakis, Jock K. Findlay, Nuzhat Ahmed

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Prognostic impact of circulating tumor cell apoptosis and clusters in serial blood samples from patients with metastatic breast cancer in a prospective observational cohort

Sara Jansson, Pär-Ola Bendahl, Anna-Maria Larsson, Kristina E. Aaltonen, Lisa Rydén

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Prognostic implications of PD-L1 expression in patients with soft tissue sarcoma

Chan Kim, Eun Kyung Kim, Hun Jung, Hong Jae Chon, Jung Woo Han, Kyoo-Ho Shin, Hyuk Hu, Kyung Sik Kim, Young Deuk Choi, Sunghoon Kim, Young Han Lee, Jin-Suck Suh, Joong Bae Ahn, Hyun Cheol Chung, Sung Hoon Noh, Sun Young Rha, Soo Hee Kim, Hyo Song Kim

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

Colorectal cancer health services research study protocol: the CCR-CARESS observational prospective cohort project

José M. Quintana, Nerea Gonzalez, Ane Anton-Ladislao, Maximino Redondo, Marisa Bare, Nerea Fernandez de Larrea, Eduardo Briones, Antonio Escobar, Cristina Sarasqueta, Susana Garcia-Gutierrez, Urko Aguirre, for the REDISSEC-CARESS/CCR group

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Changes of Socio-demographic data of clients seeking genetic counseling for hereditary breast and ovarian cancer due to the “Angelina Jolie Effect”

Christine Staudigl, Georg Pfeiler, Katharina Hrauda, Romana Renz, Andreas Berger, Renate Lichtenschopf, Christian F. Singer, Muy-Kheng M. Tea

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Comparison of weekly administration of cisplatin versus three courses of cisplatin 100 mg/m2 for definitive radiochemotherapy of locally advanced head-and-neck cancers

Dirk Rades, Daniel Seidl, Stefan Janssen, Amira Bajrovic, Katarina Karner, Primoz Strojan, Steven E Schild

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Total antioxidant intake and prostate cancer in the Cancer of the Prostate in Sweden (CAPS) study. A case control study

Kjell M. Russnes, Elisabeth Möller, Kathryn M. Wilson, Monica Carlsen, Rune Blomhoff, Sigbjørn Smeland, Hans-Olov Adami, Henrik Grönberg, Lorelei A. Mucci, Katarina Bälter

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The triptolide derivative MRx102 inhibits Wnt pathway activation and has potent anti-tumor effects in lung cancer

Theresa A. Reno, Sun-Wing Tong, Jun Wu, John M. Fidler, Rebecca Nelson, Jae Y. Kim, Dan J. Raz

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The anti-tumor effect of the quinoline-3-carboxamide tasquinimod: blockade of recruitment of CD11b+ Ly6Chi cells to tumor tissue reduces tumor growth

Adnan Deronic, Sahar Tahvili, Tomas Leanderson, Fredrik Ivars

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Osteopontin splice variants are differential predictors of breast cancer treatment responses

Krzysztof Zduniak, Anil Agrawal, Siddarth Agrawal, Md Monir Hossain, Piotr Ziolkowski, Georg F. Weber

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Clinical relevance of peroxisome proliferator-activated receptor-gamma expression in myxoid liposarcoma

Akihiko Takeuchi, Norio Yamamoto, Toshiharu Shirai, Katsuhiro Hayashi, Shinji Miwa, Seiichi Munesue, Yasuhiko Yamamoto, Hiroyuki Tsuchiya

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Erlotinib plus gemcitabine versus gemcitabine for pancreatic cancer: real-world analysis of Korean national database

Sangjin Shin, Chan Mi Park, Hanbyeol Kwon, Kyung-Hun Lee

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Spinal disease in myeloma: cohort analysis at a specialist spinal surgery centre indicates benefit of early surgical augmentation or bracing

Karan Malhotra, Joseph S. Butler, Hai Ming Yu, Susanne Selvadurai, Shirley D’Sa, Neil Rabin, Charalampia Kyriakou, Kwee Yong, Sean Molloy

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

Implementation of immunochemical faecal occult blood test in general practice: a study protocol using a cluster-randomised stepped-wedge design

Jakob Søgaard Juul, Flemming Bro, Nete Hornung, Berit Sanne Andersen, Søren Laurberg, Frede Olesen, Peter Vedsted

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Population attributable fraction of Esophageal squamous cell carcinoma due to smoking and alcohol in Uganda

Samson Okello, Cristina Churchill, Rogers Owori, Benson Nasasira, Christine Tumuhimbise, Charles Lagoro Abonga, David Mutiibwa, David C. Christiani, Kathleen E. Corey

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Alveolar Rhabdomyosarcoma of the foot metastasizing to the Iris: report of a rare case

Ido Didi Fabian, G. Darius Hildebrand, Shaun Wilson, Tina Foord, Mandeep S. Sagoo

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Prognostic significance of annexin A2 and annexin A4 expression in patients with cervical cancer

Chel Hun Choi, Joon-Yong Chung, Eun Joo Chung, John D. Sears, Jeong-Won Lee, Duk-Soo Bae, Stephen M. Hewitt

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Fast-track surgery improves postoperative clinical recovery and cellular and humoral immunity after esophagectomy for esophageal cancer

Lantao Chen, Lixin Sun, Yaoguo Lang, Jun Wu, Lei Yao, Jinfeng Ning, Jinfeng Zhang, Shidong Xu

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Retrospective and comparative analysis of 99mTc-Sestamibi breast specific gamma imaging versus mammography, ultrasound, and magnetic resonance imaging for the detection of breast cancer in Chinese women

Xiuyan Yu, Guoming Hu, Zhigang Zhang, Fuming Qiu, Xuan Shao, Xiaochen Wang, Hongwei Zhan, Yiding Chen, Yongchuan Deng, Jian Huang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Clinical outcomes and prognostic factors of cyberknife stereotactic body radiation therapy for unresectable hepatocellular carcinoma

Jenny Que, Hsing-Tao Kuo, Li-Ching Lin, Kuei-Li Lin, Chia-Hui Lin, Yu-Wei Lin, Ching-Chieh Yang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Silibinin induces mitochondrial NOX4-mediated endoplasmic reticulum stress response and its subsequent apoptosis

Sang-Hun Kim, Kwang-Youn Kim, Sun-Nyoung Yu, Young-Kyo Seo, Sung-Sik Chun, Hak-Sun Yu, Soon-Cheol Ahn

01.12.2016 | Debate | Ausgabe 1/2016 Open Access

Insulin-like growth factor-1 signaling in renal cell carcinoma

Adam F. Tracz, Cezary Szczylik, Camillo Porta, Anna M. Czarnecka

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Highly sensitive detection of the PIK3CA H1047R mutation in colorectal cancer using a novel PCR-RFLP method

Wan-Ming Li, Ting-Ting Hu, Lin-Lin Zhou, Yi-Ming Feng, Yun-Yi Wang, Jin Fang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Combination of a third generation bisphosphonate and replication-competent adenoviruses augments the cytotoxicity on mesothelioma

Yuanyuan Jiang, Boya Zhong, Kiyoko Kawamura, Takao Morinaga, Masato Shingyoji, Ikuo Sekine, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Health professionals and the early detection of head and neck cancers: a population-based study in a high incidence area

Karine Ligier, Olivier Dejardin, Ludivine Launay, Emmanuel Benoit, Emmanuel Babin, Simona Bara, Bénédicte Lapôtre-Ledoux, Guy Launoy, Anne-Valérie Guizard

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

COX-2 rs689466, rs5275, and rs20417 polymorphisms and risk of head and neck squamous cell carcinoma: a meta-analysis of adjusted and unadjusted data

Wei-Dong Leng, Xiu-Jie Wen, Joey S. W. Kwong, Wei Huang, Jian-Gang Chen, Xian-Tao Zeng

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

5-lipoxygenase mediates docosahexaenoyl ethanolamide and N-arachidonoyl-L-alanine-induced reactive oxygen species production and inhibition of proliferation of head and neck squamous cell carcinoma cells

Seok-Woo Park, J. Hun Hah, Sang-Mi Oh, Woo-Jin Jeong, Myung-Whun Sung

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The impact of breast cancer biological subtyping on tumor size assessment by ultrasound and mammography - a retrospective multicenter cohort study of 6543 primary breast cancer patients

Roland Gregor Stein, Daniel Wollschläger, Rolf Kreienberg, Wolfgang Janni, Manfred Wischnewsky, Joachim Diessner, Tanja Stüber, Catharina Bartmann, Mathias Krockenberger, Jörg Wischhusen, Achim Wöckel, Maria Blettner, Lukas Schwentner, the BRENDA Study Group

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Poor survival in stage IIB/C (T4N0) compared to stage IIIA (T1-2 N1, T1N2a) colon cancer persists even after adjusting for adequate lymph nodes retrieved and receipt of adjuvant chemotherapy

Quyen D. Chu, Meijiao Zhou, Kaelen L. Medeiros, Prakash Peddi, Mindie Kavanaugh, Xiao-Cheng Wu

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Combination of VP3 and CD147-knockdown enhance apoptosis and tumor growth delay index in colorectal tumor allograft

Ruzila Ismail, Zeenathul Nazariah Allaudin, Rasedee Abdullah, Mohd-Azmi Mohd Lila, Nik-Mohd-Afizan Nik Abd. Rahman, Sheikh-Omar Abdul Rahman

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Antitumour responses induced by a cell-based Reovirus vaccine in murine lung and melanoma models

Ciorsdan A. Campion, Declan Soden, Patrick F. Forde

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Pleural fluid osteopontin, vascular endothelial growth factor, and urokinase-type plasminogen activator levels as predictors of pleurodesis outcome and prognosticators in patients with malignant pleural effusion: a prospective cohort study

Li-Han Hsu, Pei-Chi Hsu, Tien-Ling Liao, An-Chen Feng, Nei-Min Chu, Shu-Huei Kao

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Phase I/II dose-finding study of nanoparticle albumin-bound paclitaxel (nab®-Paclitaxel) plus Cisplatin as Treatment for Metastatic Nasopharyngeal Carcinoma

Yan Huang, Wenhua Liang, Yunpeng Yang, Liping Zhao, Hongyun Zhao, Xuan Wu, Yuanyuan Zhao, Yang Zhang, Li Zhang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The overexpression of p16 is not a surrogate marker for high-risk human papilloma virus genotypes and predicts clinical outcomes for vulvar cancer

Jacek J. Sznurkowski, Anton Żawrocki, Wojciech Biernat

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

A pilot study to determine the timing and effect of bevacizumab on vascular normalization of metastatic brain tumors in breast cancer

Bang-Bin Chen, Yen-Shen Lu, Ching-Hung Lin, Wei-Wu Chen, Pei-Fang Wu, Chao-Yu Hsu, Chih-Wei Yu, Shwu-Yuan Wei, Ann-Lii Cheng, Tiffany Ting-Fang Shih

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Chemotherapy induced neutropenia at 1-month mark is a predictor of overall survival in patients receiving TAS-102 for refractory metastatic colorectal cancer: a cohort study

Pashtoon M. Kasi, Daisuke Kotani, Michael Cecchini, Kohei Shitara, Atsushi Ohtsu, Ramesh K. Ramanathan, Howard S. Hochster, Axel Grothey, Takayuki Yoshino

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Neoadjuvant irinotecan, cisplatin, and concurrent radiation therapy with celecoxib for patients with locally advanced esophageal cancer

James M. Cleary, Harvey J. Mamon, Jackie Szymonifka, Raphael Bueno, Noah Choi, Dean M. Donahue, Panos M. Fidias, Henning A. Gaissert, Michael T. Jaklitsch, Matthew H. Kulke, Thomas P. Lynch, Steven J. Mentzer, Jeffrey A. Meyerhardt, Richard S. Swanson, John Wain, Charles S. Fuchs, Peter C. Enzinger

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Differential cytotoxicity induced by the Titanium(IV)Salan complex Tc52 in G2-phase independent of DNA damage

Theresa Pesch, Harald Schuhwerk, Philippe Wyrsch, Timo Immel, Wilhelm Dirks, Alexander Bürkle, Thomas Huhn, Sascha Beneke

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

EHD1 confers resistance to cisplatin in non-small cell lung cancer by regulating intracellular cisplatin concentrations

Jing Gao, Qingwei Meng, Yanbin Zhao, Xuesong Chen, Li Cai

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

SOX2 expression is associated with a cancer stem cell state and down-regulation of CDX2 in colorectal cancer

Ida V. Lundberg, Sofia Edin, Vincy Eklöf, Åke Öberg, Richard Palmqvist, Maria L. Wikberg

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

PROX1 and β-catenin are prognostic markers in pancreatic ductal adenocarcinoma

Kapo Saukkonen, Jaana Hagström, Harri Mustonen, Anne Juuti, Stig Nordling, Pauliina Kallio, Kari Alitalo, Hanna Seppänen, Caj Haglund

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Modeling and simulation of maintenance treatment in first-line non-small cell lung cancer with external validation

Kelong Han, Laurent Claret, Alan Sandler, Asha Das, Jin Jin, Rene Bruno

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice

J. R. Hens, I. Sinha, F. Perodin, T. Cooper, R. Sinha, J. Plummer, C. E. Perrone, D. Orentreich

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

No preclinical rationale for IGF1R directed therapy in chondrosarcoma of bone

Elisabeth F. P. Peterse, Arjen H. G. Cleven, Yvonne De Jong, Inge Briaire-de Bruijn, Jonathan A. Fletcher, Erik H. J. Danen, Anne-Marie Cleton-Jansen, Judith V. M. G. Bovée

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Bile acids destabilise HIF-1α and promote anti-tumour phenotypes in cancer cell models

J. P. Phelan, F. J. Reen, N. Dunphy, R. O’Connor, F. O’Gara

01.12.2016 | Technical advance | Ausgabe 1/2016 Open Access

Method for semi-automated microscopy of filtration-enriched circulating tumor cells

Emma Pailler, Marianne Oulhen, Fanny Billiot, Alexandre Galland, Nathalie Auger, Vincent Faugeroux, Corinne Laplace-Builhé, Benjamin Besse, Yohann Loriot, Maud Ngo-Camus, Merouan Hemanda, Colin R. Lindsay, Jean-Charles Soria, Philippe Vielh, Françoise Farace

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Clinicopathological features and prognosis of gastric cancer in young patients

Shushang Liu, Fan Feng, Guanghui Xu, Zhen Liu, Yangzi Tian, Man Guo, Xiao Lian, Lei Cai, Daiming Fan, Hongwei Zhang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Results of sub-analysis of a phase 2 study on trabectedin treatment for extraskeletal myxoid chondrosarcoma and mesenchymal chondrosarcoma

Hideo Morioka, Shunji Takahashi, Nobuhito Araki, Hideshi Sugiura, Takafumi Ueda, Mitsuru Takahashi, Tsukasa Yonemoto, Hiroaki Hiraga, Toru Hiruma, Toshiyuki Kunisada, Akihiko Matsumine, Michiro Susa, Robert Nakayama, Kazumasa Nishimoto, Kazutaka Kikuta, Keisuke Horiuchi, Akira Kawai

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Serum fibrinogen levels are positively correlated with advanced tumor stage and poor survival in patients with gastric cancer undergoing gastrectomy: a large cohort retrospective study

Xuefeng Yu, Fulan Hu, Qiang Yao, Chunfeng Li, Hongfeng Zhang, Yingwei Xue

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The Alberta Moving Beyond Breast Cancer (AMBER) Cohort Study: Recruitment, Baseline Assessment, and Description of the First 500 Participants

Kerry S. Courneya, Margaret L. McNeely, S. Nicole Culos-Reed, Jeff K. Vallance, Gordon J. Bell, John R. Mackey, Charles E. Matthews, Andria R. Morielli, Diane Cook, Sarah MacLaughlin, Megan S. Farris, Stephanie Voaklander, Rachel O’Reilly, Christine M. Friedenreich

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Etoposide damages female germ cells in the developing ovary

Agnes Stefansdottir, Zoe C. Johnston, Nicola Powles-Glover, Richard A. Anderson, Ian R. Adams, Norah Spears

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Osteopontin and thrombospondin-1 play opposite roles in promoting tumor aggressiveness of primary resected non-small cell lung cancer

Mathieu Rouanne, Julien Adam, Aïcha Goubar, Angélique Robin, Caroline Ohana, Emilie Louvet, Jiemin Cormier, Olaf Mercier, Peter Dorfmüller, Soly Fattal, Vincent Thomas de Montpreville, Thierry Lebret, Philippe Dartevelle, Elie Fadel, Benjamin Besse, Ken André Olaussen, Christian Auclair, Jean-Charles Soria

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Determining intrafractional prostate motion using four dimensional ultrasound system

Mariwan Baker, Claus F. Behrens

01.12.2016 | Technical advance | Ausgabe 1/2016 Open Access

Efficient generation of patient-matched malignant and normal primary cell cultures from clear cell renal cell carcinoma patients: clinically relevant models for research and personalized medicine

Nazleen C. Lobo, Craig Gedye, Anthony J. Apostoli, Kevin R. Brown, Joshua Paterson, Natalie Stickle, Michael Robinette, Neil Fleshner, Robert J. Hamilton, Girish Kulkarni, Alexandre Zlotta, Andrew Evans, Antonio Finelli, Jason Moffat, Michael A. S. Jewett, Laurie Ailles

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Subcellular differential expression of Ep-ICD in oral dysplasia and cancer is associated with disease progression and prognosis

Raj Thani Somasundaram, Jatinder Kaur, Iona Leong, Christina MacMillan, Ian J. Witterick, Paul G. Walfish, Ranju Ralhan

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Everolimus downregulates estrogen receptor and induces autophagy in aromatase inhibitor-resistant breast cancer cells

Asona Lui, Jacob New, Joshua Ogony, Sufi Thomas, Joan Lewis-Wambi

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Chronic kidney disease and the risk of cancer: an individual patient data meta-analysis of 32,057 participants from six prospective studies

Germaine Wong, Natalie Staplin, Jonathan Emberson, Colin Baigent, Robin Turner, John Chalmers, Sophia Zoungas, Carol Pollock, Bruce Cooper, David Harris, Jie Jin. Wang, Paul Mitchell, Richard Prince, Wai Hon. Lim, Joshua Lewis, Jeremy Chapman, Jonathan Craig

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

MICAL1 controls cell invasive phenotype via regulating oxidative stress in breast cancer cells

Wenjie Deng, Yueyuan Wang, Luo Gu, Biao Duan, Jie Cui, Yujie Zhang, Yan Chen, Shixiu Sun, Jing Dong, Jun Du

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis

Igor Snapkov, Carl Otto Öqvist, Yngve Figenschau, Per Kogner, John Inge Johnsen, Baldur Sveinbjørnsson

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

AT-101 enhances gefitinib sensitivity in non-small cell lung cancer with EGFR T790M mutations

Ren Zhao, Shun Zhou, Bing Xia, Cui-ying Zhang, Ping Hai, Hong Zhe, Yan-yang Wang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Incorporating Yttrium-90 trans-arterial radioembolization (TARE) in the treatment of metastatic pancreatic adenocarcioma: a single center experience

Alexander Y. Kim, Keith Unger, Hongkun Wang, Michael J. Pishvaian

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Identification of V-ATPase as a molecular sensor of SOX11-levels and potential therapeutic target for mantle cell lymphoma

Venera Kuci Emruli, Roger Olsson, Fredrik Ek, Sara Ek

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Serum MMP7, MMP10 and MMP12 level as negative prognostic markers in colon cancer patients

Fee Klupp, Lena Neumann, Christoph Kahlert, Johannes Diers, Niels Halama, Clemens Franz, Thomas Schmidt, Moritz Koch, Juergen Weitz, Martin Schneider, Alexis Ulrich

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

MicroRNA-183 suppresses cancer stem-like cell properties in EBV-associated nasopharyngeal carcinoma

Chartia Ching-Mei Cheung, Samantha Wei-Man Lun, Grace Tin-Yun Chung, Chit Chow, Carman Lo, Kwong-Wai Choy, Kwok-Wai Lo

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

New anti-cancer chemicals Ertredin and its derivatives, regulate oxidative phosphorylation and glycolysis and suppress sphere formation in vitro and tumor growth in EGFRvIII-transformed cells

Sonoko Atsumi, Chisato Nosaka, Hayamitsu Adachi, Tomoyuki Kimura, Yoshihiko Kobayashi, Hisashi Takada, Takumi Watanabe, Shun-ichi Ohba, Hiroyuki Inoue, Manabu Kawada, Masakatsu Shibasaki, Masabumi Shibuya

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Changes in mitochondrial stability during the progression of the Barrett’s esophagus disease sequence

N. J. O’Farrell, R. Feighery, S. L. Picardo, N. Lynam-Lennon, M. Biniecka, S. A. McGarrigle, J. J. Phelan, F. MacCarthy, D. O’Toole, E. J. Fox, N. Ravi, J. V. Reynolds, J. O’Sullivan

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Are preoperative histology and MRI useful for classification of endometrial cancer risk?

Noemie Body, Vincent Lavoué, Olivier De Kerdaniel, Fabrice Foucher, Sébastien Henno, Aurélie Cauchois, Bruno Laviolle, Marc Leblanc, Jean Levêque

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

POSITIVE study: physical exercise program in non-operable lung cancer patients undergoing palliative treatment

Joachim Wiskemann, Simone Hummler, Christina Diepold, Melanie Keil, Ulrich Abel, Karen Steindorf, Philipp Beckhove, Cornelia M. Ulrich, Martin Steins, Michael Thomas

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

Phase II study of metformin for reduction of obesity-associated breast cancer risk: a randomized controlled trial protocol

Jessica A. Martinez, Pavani Chalasani, Cynthia A. Thomson, Denise Roe, Maria Altbach, Jean-Philippe Galons, Alison Stopeck, Patricia A. Thompson, Diana Evelyn Villa-Guillen, H-H. Sherry Chow

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Combined chemoradiation of cisplatin versus carboplatin in cervical carcinoma: a single institution experience from Thailand

Ekkasit Tharavichitkul, Vicharn Lorvidhaya, Pimkhuan Kamnerdsupaphon, Vimol Sukthomya, Somvilai Chakrabandhu, Pitchayaponne Klunklin, Wimrak Onchan, Bongkoch Supawongwattana, Nantaka Pukanhaphan, Razvan Galalae, Imjai Chitapanarux

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Galectin-3 interacts with components of the nuclear ribonucleoprotein complex

Katharina Fritsch, Marco Mernberger, Andrea Nist, Thorsten Stiewe, Alexander Brehm, Ralf Jacob

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

ESOPEC: prospective randomized controlled multicenter phase III trial comparing perioperative chemotherapy (FLOT protocol) to neoadjuvant chemoradiation (CROSS protocol) in patients with adenocarcinoma of the esophagus (NCT02509286)

Jens Hoeppner, Florian Lordick, Thomas Brunner, Torben Glatz, Peter Bronsert, Nadine Röthling, Claudia Schmoor, Dietmar Lorenz, Christian Ell, Ulrich T. Hopt, J. Rüdiger Siewert

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

CPA-7 influences immune profile and elicits anti-prostate cancer effects by inhibiting activated STAT3

Meihua Liang, Fei Zhan, Juan Zhao, Qi Li, Jiazi Wuyang, Guannan Mu, Dianjun Li, Yanqiao Zhang, Xiaoyi Huang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Prognostic value of quality of life score in disease-free survivors of surgically-treated lung cancer

Young Ho Yun, Young Ae Kim, Jin Ah Sim, Ae Sun Shin, Yoon Jung Chang, Jongmog Lee, Moon Soo Kim, Young Mog Shim, Jae lll Zo

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Association of preoperative EpCAM Circulating Tumor Cells and peripheral Treg cell levels with early recurrence of hepatocellular carcinoma following radical hepatic resection

Yan Zhou, Beili Wang, Jiong Wu, Chunyan Zhang, Yiwen Zhou, XinRong Yang, Jian Zhou, Wei Guo, Jia Fan

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Occult invasive cervical cancer after simple hysterectomy: a multi-center retrospective study of 89 cases

Huimin Bai, Dongyan Cao, Fang Yuan, Huilan Wang, Jie Chen, Yue Wang, Keng Shen, Zhenyu Zhang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

ROR2 is epigenetically inactivated in the early stages of colorectal neoplasia and is associated with proliferation and migration

Sean S. Q. Ma, Sameer Srivastava, Estelle Llamosas, Nicholas J. Hawkins, Luke B. Hesson, Robyn L. Ward, Caroline E. Ford

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Y90 Radioembolization in chemo-refractory metastastic, liver dominant colorectal cancer patients: outcome assessment applying a predictive scoring system

Robert Damm, Ricarda Seidensticker, Gerhard Ulrich, Leonie Breier, Ingo G. Steffen, Max Seidensticker, Benjamin Garlipp, Konrad Mohnike, Maciej Pech, Holger Amthauer, Jens Ricke

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Cross-reactivity profiles of hybrid capture II, cobas, and APTIMA human papillomavirus assays: split-sample study

Sarah Preisler, Matejka Rebolj, Ditte Møller Ejegod, Elsebeth Lynge, Carsten Rygaard, Jesper Bonde

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Prognostic significance of FOXM1 expression and antitumor effect of FOXM1 inhibition in synovial sarcomas

Akira Maekawa, Kenichi Kohashi, Masaaki Kuda, Kunio Iura, Takeaki Ishii, Makoto Endo, Tetsuya Nakatsura, Yukihide Iwamoto, Yoshinao Oda

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

NRASQ61K mutated primary leptomeningeal melanoma in a child: case presentation and discussion on clinical and diagnostic implications

Giulia Angelino, Maria Debora De Pasquale, Luigi De Sio, Annalisa Serra, Luca Massimi, Rita De Vito, Antonio Marrazzo, Laura Lancella, Andrea Carai, Manila Antonelli, Felice Giangaspero, Marco Gessi, Laura Menchini, Laura Scarciolla, Daniela Longo, Angela Mastronuzzi

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

A multi-centred randomised trial of radical surgery versus adjuvant chemoradiotherapy after local excision for early rectal cancer

W. A. A. Borstlap, P. J. Tanis, T. W. A. Koedam, C. A. M. Marijnen, C. Cunningham, E. Dekker, M. E. van Leerdam, G. Meijer, N. van Grieken, I. D. Nagtegaal, C. J. A. Punt, M. G. W. Dijkgraaf, J. H. De Wilt, G. Beets, E. J. de Graaf, A. A. W van Geloven, M. F. Gerhards, H. L. van Westreenen, A. W. H. van de Ven, P. van Duijvendijk, I. H. J. T. de Hingh, J. W. A. Leijtens, C. Sietses, E. J. Spillenaar-Bilgen, R. J. C. L. M. Vuylsteke, C. Hoff, J. W. A. Burger, W. M. U. van Grevenstein, A. Pronk, R. J. I. Bosker, H. Prins, A. B. Smits, S. Bruin, D. D. Zimmerman, L. P. S. Stassen, M. S. Dunker, M. Westerterp, P. P. Coene, J. Stoot, W. A. Bemelman, J. B. Tuynman

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

CXCL12 expression promotes esophageal squamous cell carcinoma proliferation and worsens the prognosis

Yusuke Uchi, Hiroya Takeuchi, Sachiko Matsuda, Yoshiro Saikawa, Hirofumi Kawakubo, Norihito Wada, Tsunehiro Takahashi, Rieko Nakamura, Kazumasa Fukuda, Tai Omori, Yuko Kitagawa

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Prognostic impact of AJCC response criteria for neoadjuvant chemotherapy in stage II/III breast cancer patients: breast cancer subtype analyses

Yaewon Yang, Seock-Ah Im, Bhumsuk Keam, Kyung‑Hun Lee, Tae‑Yong Kim, Koung Jin Suh, Han Suk Ryu, Hyeong-Gon Moon, Sae‑Won Han, Do‑Youn Oh, Wonshik Han, Tae‑You Kim, In Ae Park, Dong-Young Noh

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

High level of serum apolipoprotein A-I is a favorable prognostic factor for overall survival in esophageal squamous cell carcinoma

Xue-Ping Wang, Xiao-Hui Li, Lin Zhang, Jian-Hua Lin, Hao Huang, Ting Kang, Min-Jie Mao, Hao Chen, Xin Zheng

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

A randomized cross-over trial to detect differences in arm volume after low- and heavy-load resistance exercise among patients receiving adjuvant chemotherapy for breast cancer at risk for arm lymphedema: study protocol

Kira Bloomquist, Sandi Hayes, Lis Adamsen, Tom Møller, Karl Bach Christensen, Bent Ejlertsen, Peter Oturai

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: Survival, safety, and prognostic factors for outcome with Regorafenib in patients with metastatic colorectal cancer refractory to standard therapies: results from a multicenter study (REBECCA) nested within a compassionate use program

Antoine Adenis, Christelle de la Fouchardiere, Bernard Paule, Pascal Burtin, David Tougeron, Jennifer Wallet, Louis-Marie Dourthe, Pierre-Luc Etienne, Laurent Mineur, Stéphanie Clisant, Jean-Marc Phelip, Andrew Kramar, Thierry Andre

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Predictive value of vrk 1 and 2 for rectal adenocarcinoma response to neoadjuvant chemoradiation therapy: a retrospective observational cohort study

Laura del Puerto-Nevado, Juan Pablo Marin-Arango, Maria Jesus Fernandez-Aceñero, David Arroyo-Manzano, Javier Martinez-Useros, Aurea Borrero-Palacios, Maria Rodriguez-Remirez, Arancha Cebrian, Teresa Gomez del Pulgar, Marlid Cruz-Ramos, Cristina Carames, Begoña Lopez-Botet, Jesús Garcia-Foncillas

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

The effectiveness of a nurse-led intervention with the distress thermometer for patients treated with curative intent for breast cancer: design of a randomized controlled trial

Floortje K. Ploos van Amstel, Judith B. Prins, Winette T. A. van der Graaf, Marlies E. W. J. Peters, Petronella B. Ottevanger

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

p53-independent structure-activity relationships of 3-ring mesogenic compounds’ activity as cytotoxic effects against human non-small cell lung cancer lines

Saori Fukushi, Hironori Yoshino, Atsushi Yoshizawa, Ikuo Kashiwakura

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Comparison of the HER2, estrogen and progesterone receptor expression profile of primary tumor, metastases and circulating tumor cells in metastatic breast cancer patients

Bahriye Aktas, Sabine Kasimir-Bauer, Volkmar Müller, Wolfgang Janni, Tanja Fehm, Diethelm Wallwiener, Klaus Pantel, Mitra Tewes, on behalf of the DETECT Study Group

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Is monitoring of plasma 5-fluorouracil levels in metastatic / advanced colorectal cancer clinically effective? A systematic review

Karoline Freeman, Mark P. Saunders, Olalekan A. Uthman, Sian Taylor-Phillips, Martin Connock, Rachel Court, Tara Gurung, Paul Sutcliffe, Aileen Clarke

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Utilizing native fluorescence imaging, modeling and simulation to examine pharmacokinetics and therapeutic regimen of a novel anticancer prodrug

Jing-Hung Wang, Aaron N. Endsley, Carol E. Green, A. C. Matin

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The combined expression of Semaphorin4D and PlexinB1 predicts disease recurrence in colorectal cancer

Tetsuro Ikeya, Kiyoshi Maeda, Hisashi Nagahara, Masatsune Shibutani, Yasuhito Iseki, Kosei Hirakawa

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Real-time HER2 status detected on circulating tumor cells predicts different outcomes of anti-HER2 therapy in histologically HER2-positive metastatic breast cancer patients

Shaohua Zhang, Lei Li, Tao Wang, Li Bian, Haixu Hu, Chunhong Xu, Bing Liu, Yi Liu, Massimo Cristofanilli, Zefei Jiang

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

Study protocol of the CAREST-trial: a randomised controlled trial on the (cost-) effectiveness of a CBT-based online self-help training for fear of cancer recurrence in women with curatively treated breast cancer

Sanne Jasperine van Helmondt, Marije Liesbeth van der Lee, Jolanda de Vries

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Survival and prognostic factors in patients with stable and unstable spinal bone metastases from solid tumors: a retrospective analysis of 915 cases

Robert J. Wolf, Robert Foerster, Thomas Bruckner, Tilman Bostel, Ingmar Schlampp, Juergen Debus, Harald Rief, German Bone Research Group

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

A cohort analysis of men with a family history of BRCA1/2 and Lynch mutations for prostate cancer

Lynne Kerr, Matthew J. Rewhorn, Mark Longmuir, Sioban Fraser, Shaun Walsh, Nicola Andrew, Hing Y. Leung

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Foxp3 overexpression in tumor cells predicts poor survival in oral squamous cell carcinoma

Jing-Jing Song, Si-Jia Zhao, Juan Fang, Da Ma, Xiang-Qi Liu, Xiao-Bing Chen, Yun Wang, Bin Cheng, Zhi Wang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Pro-survival responses to the dual inhibition of anti-apoptotic Bcl-2 family proteins and mTOR-mediated signaling in hypoxic colorectal carcinoma cells

Karianne Risberg, Kathrine Røe Redalen, Linda Sønstevold, Tonje Bjørnetrø, Janne Sølvernes, Anne Hansen Ree

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Saikosaponin d induces cell death through caspase-3-dependent, caspase-3-independent and mitochondrial pathways in mammalian hepatic stellate cells

Ming-Feng Chen, S. Joseph Huang, Chao-Cheng Huang, Pei-Shan Liu, Kun-I Lin, Ching-Wen Liu, Wen-Chuan Hsieh, Li-Yen Shiu, Chang-Han Chen

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Vascular disruptive agent OXi4503 and anti-angiogenic agent Sunitinib combination treatment prolong survival of mice with CRC liver metastasis

Linh Nguyen, Theodora Fifis, Christopher Christophi

01.12.2016 | Research Article | Ausgabe 1/2016 Open Access

Pseudo-HE images derived from CARS/TPEF/SHG multimodal imaging in combination with Raman-spectroscopy as a pathological screening tool

Thomas W. Bocklitz, Firas Subhi Salah, Nadine Vogler, Sandro Heuke, Olga Chernavskaia, Carsten Schmidt, Maximilian J. Waldner, Florian R. Greten, Rolf Bräuer, Michael Schmitt, Andreas Stallmach, Iver Petersen, Jürgen Popp

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis

Sandra Fernandes Martins, Ricardo Amorim, Marta Viana-Pereira, Céline Pinheiro, Ricardo Filipe Alves Costa, Patrícia Silva, Carla Couto, Sara Alves, Sara Fernandes, Sónia Vilaça, Joaquim Falcão, Herlander Marques, Fernando Pardal, Mesquita Rodrigues, Ana Preto, Rui Manuel Reis, Adhemar Longatto-Filho, Fátima Baltazar

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Circulating proteins in response to combined-modality therapy in rectal cancer identified by antibody array screening

Erta Kalanxhi, Helga Helseth Hektoen, Sebastian Meltzer, Svein Dueland, Kjersti Flatmark, Anne Hansen Ree

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Rituximab plus chemotherapy as first-line treatment in Chinese patients with diffuse large B-cell lymphoma in routine practice: a prospective, multicentre, non-interventional study

Jianqiu Wu, Yongping Song, Liping Su, Li Xu, Tingchao Chen, Zhiyun Zhao, Mingzhi Zhang, Wei Li, Yu Hu, Xiaohong Zhang, Yuhuan Gao, Zuoxing Niu, Ru Feng, Wei Wang, Jiewen Peng, Xiaolin Li, Xuenong Ouyang, Changping Wu, Weijing Zhang, Yun Zeng, Zhen Xiao, Yingmin Liang, Yongzhi Zhuang, Jishi Wang, Zimin Sun, Hai Bai, Tongjian Cui, Jifeng Feng

01.12.2016 | Debate | Ausgabe 1/2016 Open Access

Atypical ubiquitin ligase RNF31: the nuclear factor modulator in breast cancer progression

Jian Zhu, Ting Zhuang, Huijie Yang, Xin Li, Huandi Liu, Hui Wang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Transcriptome analysis of paired primary colorectal carcinoma and liver metastases reveals fusion transcripts and similar gene expression profiles in primary carcinoma and liver metastases

Ja-Rang Lee, Chae Hwa Kwon, Yuri Choi, Hye Ji Park, Hyun Sung Kim, Hong-Jae Jo, Nahmgun Oh, Do Youn Park

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

PAC down-regulates estrogen receptor alpha and suppresses epithelial-to-mesenchymal transition in breast cancer cells

Huda A. Al-Howail, Hana A. Hakami, Basem Al-Otaibi, Amer Al-Mazrou, Maha H. Daghestani, Ibrahim Al-Jammaz, Huda H. Al-Khalaf, Abdelilah Aboussekhra

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The association of infrared imaging findings of the breast with prognosis in breast cancer patients: an observational cohort study

Li-An Wu, Wen-Hung Kuo, Chin-Yu Chen, Yuh-Show Tsai, Jane Wang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed

Boris Decarolis, Thorsten Simon, Barbara Krug, Ivo Leuschner, Christian Vokuhl, Peter Kaatsch, Dietrich von Schweinitz, Thomas Klingebiel, Ingo Mueller, Lothar Schweigerer, Frank Berthold, Barbara Hero

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

A case report: delayed high fever and maculopapules during Sorafenib treatment of ectopic hepatocellular carcinoma

Tianxiang Cui, Xinwei Diao, Xiewan Chen, Shaojiang Huang, Jianguo Sun

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

Effectiveness of work-related medical rehabilitation in cancer patients: study protocol of a cluster-randomized multicenter trial

Julian Wienert, Betje Schwarz, Matthias Bethge

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Bifidobacterial recombinant thymidine kinase-ganciclovir gene therapy system induces FasL and TNFR2 mediated antitumor apoptosis in solid tumors

Changdong Wang, Yongping Ma, Qiongwen Hu, Tingting Xie, Jiayan Wu, Fan Zeng, Fangzhou Song

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Microsatellite alteration and immunohistochemical expression profile of chromosome 9p21 in patients with sporadic renal cell carcinoma following surgical resection

Ismail El-Mokadem, Alison Lim, Thomas Kidd, Katherine Garret, Norman Pratt, David Batty, Stewart Fleming, Ghulam Nabi

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Angiogenic cytokines and their influence on circulating tumour cells in sera of patients with the primary diagnosis of breast cancer before treatment

Theresa Vilsmaier, Brigitte Rack, Wolfgang Janni, Udo Jeschke, Tobias Weissenbacher, SUCCESS Study Group

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Induction of artificial cancer stem cells from tongue cancer cells by defined reprogramming factors

Koji Harada, Tarannum Ferdous, Dan Cui, Yasuhiro Kuramitsu, Takuya Matsumoto, Eiji Ikeda, Hideyuki Okano, Yoshiya Ueyama

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Expression of circadian clock genes and proteins in urothelial cancer is related to cancer-associated genes

Jorunn Litlekalsoy, Kari Rostad, Karl-Henning Kalland, Jens G. Hostmark, Ole Didrik Laerum

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

MK-2206 sensitizes BRCA-deficient epithelial ovarian adenocarcinoma to cisplatin and olaparib

Margaret E. Whicker, Z. Ping Lin, Ruth Hanna, Alan C. Sartorelli, Elena S. Ratner

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Palmitate-induced ER stress increases trastuzumab sensitivity in HER2/neu-positive breast cancer cells

Jan Baumann, Jason Wong, Yan Sun, Douglas S. Conklin

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

A rare case of extremely high counts of circulating tumor cells detected in a patient with an oral squamous cell carcinoma

Xianglei Wu, Romina Mastronicola, Qian Tu, Gilbert Charles Faure, Marcelo De Carvalho Bittencourt, Gilles Dolivet

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

PIK3CA dependence and sensitivity to therapeutic targeting in urothelial carcinoma

R. L. Ross, H. R. McPherson, L. Kettlewell, S. D. Shnyder, C. D. Hurst, O. Alder, M. A. Knowles

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Better survival in right-sided versus left-sided stage I - III colon cancer patients

Rene Warschkow, Michael C. Sulz, Lukas Marti, Ignazio Tarantino, Bruno M. Schmied, Thomas Cerny, Ulrich Güller

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The effects of lymph node status on predicting outcome in ER+ /HER2- tamoxifen treated breast cancer patients using gene signatures

Jessica G. Cockburn, Robin M. Hallett, Amy E. Gillgrass, Kay N. Dias, T. Whelan, M. N. Levine, John A. Hassell, Anita Bane

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Pre-treatment MRI minimum apparent diffusion coefficient value is a potential prognostic imaging biomarker in cervical cancer patients treated with definitive chemoradiation

Daniel Grossi Marconi, Jose Humberto Tavares Guerreiro Fregnani, Rodrigo Ribeiro Rossini, Ana Karina Borges Junqueira Netto, Fabiano Rubião Lucchesi, Audrey Tieko Tsunoda, Mitchell Kamrava

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The impact of body mass index on treatment outcomes for patients with low-intermediate risk prostate cancer

Kosj Yamoah, Charnita M. Zeigler-Johnson, Abra Jeffers, Bruce Malkowicz, Elaine Spangler, Jong Y. Park, Alice Whittemore, Timothy R. Rebbeck

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Return to work after cancer treatment of gynecologic cancer in Japan

Keiichiro Nakamura, Hisashi Masuyama, Takeshi Nishida, Junko Haraga, Naoyuki Ida, Masayuki Saijo, Tomoko Haruma, Tomoyuki Kusumoto, Noriko Seki, Yuji Hiramatsu

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Increased sensitivity of African American triple negative breast cancer cells to nitric oxide-induced mitochondria-mediated apoptosis

Luis Martinez, Easter Thames, Jinna Kim, Gautam Chaudhuri, Rajan Singh, Shehla Pervin

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Single nucleotide polymorphism rs13042395 in the SLC52A3 gene as a biomarker for regional lymph node metastasis and relapse-free survival of esophageal squamous cell carcinoma patients

Hua-Zhen Tan, Zhi-Yong Wu, Jian-Yi Wu, Lin Long, Ji-Wei Jiao, Yu-Hui Peng, Yi-Wei Xu, Shan-Shan Li, Wei Wang, Jian-Jun Zhang, En-Min Li, Li-Yan Xu

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Heat shock protein 70–2 (HSP70-2) is a novel therapeutic target for colorectal cancer and is associated with tumor growth

Nirmala Jagadish, Deepak Parashar, Namita Gupta, Sumit Agarwal, Vaishali Suri, Rajive Kumar, Vitusha Suri, Trilok Chand Sadasukhi, Anju Gupta, Abdul S. Ansari, Nirmal Kumar Lohiya, Anil Suri

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Coffee consumption and the risk of malignant melanoma in the Norwegian Women and Cancer (NOWAC) Study

Marko Lukic, Mie Jareid, Elisabete Weiderpass, Tonje Braaten

01.12.2016 | Debate | Ausgabe 1/2016 Open Access

Primary extramammary invasive Paget’s vulvar disease: what is the standard, what are the challenges and what is the future for radiotherapy?

Maria Tolia, Nikolaos Tsoukalas, Chrisostomos Sofoudis, Constantinos Giaginis, Despoina Spyropoulou, Dimitrios Kardamakis, Vasileios Kouloulias, George Kyrgias

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The occurrence of hyponatremia and its importance as a prognostic factor in a cross-section of cancer patients

Jorge J. Castillo, Ilya G. Glezerman, Susan H. Boklage, Joseph Chiodo III, Beni A. Tidwell, Lois E. Lamerato, Kathy L. Schulman

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Collapsin response mediator protein 4 isoforms (CRMP4a and CRMP4b) have opposite effects on cell proliferation, migration, and invasion in gastric cancer

Haijian Guo, Bing Xia

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Mesenchymal stem cells enhance the metastasis of 3D-cultured hepatocellular carcinoma cells

Chang Liu, Yang Liu, Xiao-xi Xu, Xin Guo, Guang-wei Sun, Xiao-jun Ma

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Protein arginine methyltransferase 5 regulates multiple signaling pathways to promote lung cancer cell proliferation

Xiumei Sheng, Zhengxin Wang

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Post-crizotinib management of effective ceritinib therapy in a patient with ALK-positive non-small cell lung cancer

Brian Won, Isa Mambetsariev, Ravi Salgia

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Socio-economic deprivation: a significant determinant affecting stage of oral cancer diagnosis and survival

Ajit Auluck, Blake Byron Walker, Greg Hislop, Scott A. Lear, Nadine Schuurman, Miriam Rosin

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Overexpression of the miR-141/200c cluster promotes the migratory and invasive ability of triple-negative breast cancer cells through the activation of the FAK and PI3K/AKT signaling pathways by secreting VEGF-A

Sul Ki Choi, Hoe Suk Kim, Tiefeng Jin, Eun Hye Hwang, Minji Jung, Woo Kyung Moon

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

CPP2-p16MIS treatment–induced colon carcinoma cell death in vitro and prolonged lifespan of tumor-bearing mice

Lifeng Wang, Haijin Chen, Jinlong Yu, Xiaohua Lin, Jia Qi, Chunhui Cui, Lang Xie, Shuxin Huang

01.12.2016 | Technical advance | Ausgabe 1/2016 Open Access

In chronic myeloid leukemia patients on second-line tyrosine kinase inhibitor therapy, deep sequencing of BCR-ABL1 at the time of warning may allow sensitive detection of emerging drug-resistant mutants

Simona Soverini, Caterina De Benedittis, Fausto Castagnetti, Gabriele Gugliotta, Manuela Mancini, Luana Bavaro, Katerina Machova Polakova, Jana Linhartova, Alessandra Iurlo, Domenico Russo, Fabrizio Pane, Giuseppe Saglio, Gianantonio Rosti, Michele Cavo, Michele Baccarani, Giovanni Martinelli

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

A HELLP syndrome complicates a gestational trophoblastic neoplasia in a perimenopausal woman: a case report

Guillaume Vogin, François Golfier, Touria Hajri, Agnès Leroux, Béatrice Weber

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The fibronectin III-1 domain activates a PI3-Kinase/Akt signaling pathway leading to αvβ5 integrin activation and TRAIL resistance in human lung cancer cells

Christina Cho, Carol Horzempa, David Jones, Paula J. McKeown-Longo

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

CHEK2 represses breast stromal fibroblasts and their paracrine tumor-promoting effects through suppressing SDF-1 and IL-6

Maha A. Al-Rakan, Siti-Faujiah Hendrayani, Abdelilah Aboussekhra

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Reproducibility and uptake time dependency of volume-based parameters on FDG-PET for lung cancer

Tomoka Kitao, Kenji Hirata, Katsumi Shima, Takashi Hayashi, Mitsunori Sekizawa, Toshiki Takei, Wataru Ichimura, Masao Harada, Keishi Kondo, Nagara Tamaki

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

A retrospective study of predictive factors for unexpectedly prolonged or shortened progression-free survival and overall survival among patients with metastatic renal cell carcinoma who received first-line targeted therapy

Sung Han Kim, Sohee Kim, Jungnam Joo, Ho Kyung Seo, Jae Young Joung, Kang Hyun Lee, Jinsoo Chung

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Emodin enhances cisplatin-induced cytotoxicity in human bladder cancer cells through ROS elevation and MRP1 downregulation

Xinxing Li, Haolu Wang, Juan Wang, Yuying Chen, Xiaobin Yin, Guiying Shi, Hui Li, Zhiqian Hu, Xiaowen Liang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Health services research of integrative oncology in palliative care of patients with advanced pancreatic cancer

Jan Axtner, Megan Steele, Matthias Kröz, Günther Spahn, Harald Matthes, Friedemann Schad

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

Effectiveness and cost-utility of a guided self-help exercise program for patients treated with total laryngectomy: protocol of a multi-center randomized controlled trial

Femke Jansen, Ingrid C. Cnossen, Simone E. J. Eerenstein, Veerle M. H. Coupé, Birgit I. Witte, Cornelia F. van Uden-Kraan, Patricia Doornaert, Weibel W. Braunius, Remco De Bree, José A. U. Hardillo, Jimmie Honings, György B. Halmos, C. René Leemans, Irma M. Verdonck-de Leeuw

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Recapitulating epithelial tumor microenvironment in vitro using three dimensional tri-culture of human epithelial, endothelial, and mesenchymal cells

Surya P. Lamichhane, Neha Arya, Esther Kohler, Shengnan Xiang, Jon Christensen, V. Prasad Shastri

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Inhibition of nuclear factor-kappa B enhances the tumor growth of ovarian cancer cell line derived from a low-grade papillary serous carcinoma in p53-independent pathway

Xue Xiao, Gong Yang, Peng Bai, Shunping Gui, Tri M. Bui Nyuyen, Imelda Mercado-Uribe, Mei Yang, Juan Zou, Qintong Li, Jianguo Xiao, Bin Chang, Guangzhi Liu, He Wang, Jinsong Liu

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Long noncoding RNA TUG1 is downregulated in non-small cell lung cancer and can regulate CELF1 on binding to PRC2

Pei-Chin Lin, Hsien-Da Huang, Chun-Chi Chang, Ya-Sian Chang, Ju-Chen Yen, Chien-Chih Lee, Wen-Hsin Chang, Ta-Chih Liu, Jan-Gowth Chang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Quantitative proteomic analysis for novel biomarkers of buccal squamous cell carcinoma arising in background of oral submucous fibrosis

Wen Liu, Lijuan Zeng, Ning Li, Fei Wang, Canhua Jiang, Feng Guo, Xinqun Chen, Tong Su, Chunjiao Xu, Shanshan Zhang, Changyun Fang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

A rational two-step approach to KRAS mutation testing in colorectal cancer using high resolution melting analysis and pyrosequencing

Elisabeth Mack, Kathleen Stabla, Jorge Riera-Knorrenschild, Roland Moll, Andreas Neubauer, Cornelia Brendel

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

An exploration of men’s experiences of undergoing active surveillance for favourable-risk prostate cancer: A mixed methods study protocol

Eimear Ruane-McAteer, Joe O’Sullivan, Sam Porter, Lionne Venderbos, Gillian Prue

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer

Qing-Bai She, Sofia K. Gruvberger-Saal, Matthew Maurer, Yilun Chen, Mervi Jumppanen, Tao Su, Meaghan Dendy, Ying-Ka Ingar Lau, Lorenzo Memeo, Hugo M. Horlings, Marc J. van de Vijver, Jorma Isola, Hanina Hibshoosh, Neal Rosen, Ramon Parsons, Lao H. Saal

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Radiation recall gastritis secondary to combination of gemcitabine and erlotinib in pancreatic cancer and response to PPI - a case report

Seong Ji Choi, Hyo Jung Kim, Jae Seon Kim, Young-Tae Bak, Jun Suk Kim

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Evaluation of folate receptor 1 (FOLR1) mRNA expression, its specific promoter methylation and global DNA hypomethylation in type I and type II ovarian cancers

Sara Notaro, Daniel Reimer, Heidi Fiegl, Gabriel Schmid, Annamarie Wiedemair, Julia Rössler, Christian Marth, Alain Gustave Zeimet

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

“Safety and utility of percutaneous liver biopsy in hematopoietic stem cell transplant pediatric recipients: a retrospective study”

Natalia Maximova, Massimo Gregori, Francesca Barbieri, Antonio Pizzol, Aurelio Sonzogni

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Chemotherapy and radiation therapy elicits tumor specific T cell responses in a breast cancer patient

David Bernal-Estévez, Ramiro Sánchez, Rafael E. Tejada, Carlos Parra-López

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Pulmonary melanoma and “crazy paving” patterns in chest images: a case report and literature review

Yikuan Feng, Jianping Zhao, Qun Yang, Weining Xiong, Guohua Zhen, Yongjian Xu, Zhenxiang Zhang, Huilan Zhang

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Case report: small cell transformation and metastasis to the breast in a patient with lung adenocarcinoma following maintenance treatment with epidermal growth factor receptor tyrosine kinase inhibitors

Quan Lin, Guo-ping Cai, Kai-Yan Yang, Li Yang, Cheng-Shui Chen, Yu-Ping Li

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Casein kinase 1α has a non-redundant and dominant role within the CK1 family in melanoma progression

Tobias Sinnberg, Jun Wang, Birgit Sauer, Birgit Schittek

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: Involvement of DNMT 3B promotes epithelial-mesenchymal transition and gene expression profile of invasive head and neck squamous cell carcinomas cell lines

Li-Hsuen Chen, Wen-Lin Hsu, Yen-Ju Tseng, Dai-Wei Liu, Ching-Feng Weng

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

L1CAM as a prognostic marker in stage I endometrial cancer: a validation study

Elisabeth Smogeli, Ben Davidson, Milada Cvancarova, Arild Holth, Betina Katz, Bjørn Risberg, Gunnar Kristensen, Kristina Lindemann

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Fibrillin-1 (FBN-1) a new marker of germ cell neoplasia in situ

Z. Cierna, M. Mego, I. Jurisica, K. Machalekova, M. Chovanec, V. Miskovska, D. Svetlovska, K. Kalavska, K. Rejlekova, K. Kajo, J. Mardiak, P. Babal

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Cost-effectiveness analysis of bortezomib in combination with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (VR-CAP) in patients with previously untreated mantle cell lymphoma

Marjolijn van Keep, Kerry Gairy, Divyagiri Seshagiri, Pushpike Thilakarathne, Dawn Lee

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Comparison of detection methods and follow-up study on the tyrosine kinase inhibitors therapy in non-small cell lung cancer patients with ROS1 fusion rearrangement

Jieyu Wu, Yunen Lin, Xinming He, Haihong Yang, Ping He, Xinge Fu, Guangqiu Li, Xia Gu

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Statin use and breast cancer survival: a nationwide cohort study in Scotland

Úna C. Mc Menamin, Liam J. Murray, Carmel M. Hughes, Chris R. Cardwell

01.12.2016 | Study protocol | Ausgabe 1/2016 Open Access

Efficacy of night-time compression for breast cancer related lymphedema (LYNC): protocol for a multi-centre, randomized controlled efficacy trial

Margaret L. McNeely, Kristin L. Campbell, Marc Webster, Urve Kuusk, Karen Tracey, John Mackey

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

S6Ks isoforms contribute to viability, migration, docetaxel resistance and tumor formation of prostate cancer cells

Camila L. Amaral, Lidia B. Freitas, Rodrigo E. Tamura, Mariana R. Tavares, Isadora C. B. Pavan, Marcio C. Bajgelman, Fernando M. Simabuco

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Inconsistent results in the analysis of ALK rearrangements in non-small cell lung cancer

Johanna S. M. Mattsson, Hans Brunnström, Verena Jabs, Karolina Edlund, Karin Jirström, Stephanie Mindus, Linnéa la Fleur, Fredrik Pontén, Mats G. Karlsson, Christina Karlsson, Hirsh Koyi, Eva Brandén, Johan Botling, Gisela Helenius, Patrick Micke, Maria A. Svensson

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

A radiosensitizing effect of RAD51 inhibition in glioblastoma stem-like cells

Anaïs Balbous, Ulrich Cortes, Karline Guilloteau, Pierre Rivet, Baptiste Pinel, Mathilde Duchesne, Julie Godet, Odile Boissonnade, Michel Wager, René Jean Bensadoun, Jean-Claude Chomel, Lucie Karayan-Tapon

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

MicroRNA-21 promotes proliferation, migration, and invasion of colorectal cancer, and tumor growth associated with down-regulation of sec23a expression

Chenli Li, Lingxu Zhao, Yuan Chen, Tiantian He, Xiaowan Chen, Jiating Mao, Chunmei Li, Jianxin Lyu, Qing H. Meng

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

A nomogram for predicting pathological complete response in patients with human epidermal growth factor receptor 2 negative breast cancer

Xi Jin, Yi-Zhou Jiang, Sheng Chen, Ke-Da Yu, Ding Ma, Wei Sun, Zhi-Min Shao, Gen-Hong Di

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

A retrospective analysis of Victorian and South Australian clinical registries for prostate cancer: trends in clinical presentation and management of the disease

Rasa Ruseckaite, Kerri Beckmann, Michael O’Callaghan, David Roder, Kim Moretti, Jeremy Millar, Sue Evans

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

No inequalities in survival from colorectal cancer by education and socioeconomic deprivation - a population-based study in the North Region of Portugal, 2000-2002

Luís Antunes, Denisa Mendonça, Maria José Bento, Bernard Rachet

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: Conformational changes and translocation of tissue-transglutaminase to the plasma membranes: role in cancer cell migration

Ambrish Kumar, Jianjun Hu, Holly A. LaVoie, Kenneth B. Walsh, Donald J. DiPette, Ugra S. Singh

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: The anti-tumor effect of the quinoline-3-carboxamide tasquinimod: blockade of recruitment of CD11b+ Ly6Chi cells to tumor tissue reduces tumor growth

Adnan Deronic, Sahar Tahvili, Tomas Leanderson, Fredrik Ivars

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Imaging-genomics reveals driving pathways of MRI derived volumetric tumor phenotype features in Glioblastoma

Patrick Grossmann, David A. Gutman, William D. Dunn Jr, Chad A. Holder, Hugo J. W. L. Aerts

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Thresholds and timing of pre-operative thrombocytosis and ovarian cancer survival: analysis of laboratory measures from electronic medical records

Gabriella D. Cozzi, Jacob M. Samuel, Jason T. Fromal, Spencer Keene, Marta A. Crispens, Dineo Khabele, Alicia Beeghly-Fadiel

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Risk factors associated with early mortality in patients with multiple myeloma who were treated upfront with a novel agents containing regimen

Sung-Hoon Jung, Min-Seok Cho, Hee Kyung Kim, Seok Jin Kim, Kihyun Kim, June-Won Cheong, Soo-Jeoong Kim, Jin Seok Kim, Jae-Sook Ahn, Yeo-Kyeoung Kim, Deok-Hwan Yang, Hyeoung-Joon Kim, Je-Jung Lee, Korean Multiple Myeloma Working Party (KMMWP)

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Nanoroughened adhesion-based capture of circulating tumor cells with heterogeneous expression and metastatic characteristics

Weiqiang Chen, Steven G. Allen, Ajaya Kumar Reka, Weiyi Qian, Shuo Han, Jianing Zhao, Liwei Bao, Venkateshwar G. Keshamouni, Sofia D. Merajver, Jianping Fu

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

uPAR enhances malignant potential of triple-negative breast cancer by directly interacting with uPA and IGF1R

Michaela C. Huber, Rebecca Mall, Herbert Braselmann, Annette Feuchtinger, Sara Molatore, Katrin Lindner, Axel Walch, Eva Gross, Manfred Schmitt, Natalie Falkenberg, Michaela Aubele

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Pazolimus: pazopanib plus sirolimus following progression on pazopanib, a retrospective case series analysis

D. Katz, Y. Azraq, F. Eleyan, S. Gill, T. Peretz, O. Merimsky

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

HDAC 1 and 6 modulate cell invasion and migration in clear cell renal cell carcinoma

Swathi Ramakrishnan, ShengYu Ku, Eric Ciamporcero, Kiersten Marie Miles, Kris Attwood, Sreenivasulu Chintala, Li Shen, Leigh Ellis, Paula Sotomayor, Wendy Swetzig, Ray Huang, Dylan Conroy, Ashley Orillion, Gokul Das, Roberto Pili

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Prognostic relevance of caspase 8 -652 6N InsDel and Asp302His polymorphisms for breast cancer

J. D. Kuhlmann, A. Bankfalvi, K. W. Schmid, R. Callies, R. Kimmig, P. Wimberger, W. Siffert, H. S. Bachmann

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Efficacy and safety of Dexrazoxane (DRZ) in sarcoma patients receiving high cumulative doses of anthracycline therapy – a retrospective study including 32 patients

Markus K. Schuler, Sebastian Gerdes, Antje West, Stephan Richter, Christoph Busemann, Leopold Hentschel, Felicitas Lenz, Hans-Georg Kopp, Gerhard Ehninger, Peter Reichardt, Daniel Pink

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Optimizing the process of fertility preservation in pediatric female cancer patients – a multidisciplinary program

Irit Ben-Aharon, R. Abir, G. Perl, J. Stein, G. Gilad, H. Toledano, S. Elitzur, G. Avrahami, A. Ben-Haroush, G. Oron, E. Freud, D. Kravarusic, M. Ben-Arush, G. Herzel, I. Yaniv, S. M. Stemmer, B. Fisch, S. Ash

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

An evaluation in vitro of PARP-1 inhibitors, rucaparib and olaparib, as radiosensitisers for the treatment of neuroblastoma

Donna L. Nile, Colin Rae, Iain J. Hyndman, Mark N. Gaze, Robert J. Mairs

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

AKT1 E17K mutation profiling in breast cancer: prevalence, concurrent oncogenic alterations, and blood-based detection

Marion Rudolph, Tobias Anzeneder, Anke Schulz, Georg Beckmann, Annette T. Byrne, Michael Jeffers, Carol Pena, Oliver Politz, Karl Köchert, Richardus Vonk, Joachim Reischl

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Metronomic cyclophosphamide activation of anti-tumor immunity: tumor model, mouse host, and drug schedule dependence of gene responses and their upstream regulators

Junjie Wu, Marie Jordan, David J. Waxman

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

IAP antagonists Birinapant and AT-406 efficiently synergise with either TRAIL, BRAF, or BCL-2 inhibitors to sensitise BRAFV600E colorectal tumour cells to apoptosis

Philippos Perimenis, Apostolos Galaris, Alexandra Voulgari, Margarita Prassa, Alexander Pintzas

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Gd-EOB-DTPA-enhanced magnetic resonance imaging combined with T1 mapping predicts the degree of differentiation in hepatocellular carcinoma

Zhenpeng Peng, Mengjie Jiang, Huasong Cai, Tao Chan, Zhi Dong, Yanji Luo, Zi-Ping Li, Shi-Ting Feng

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Metabolic complete response with vinflunine as second-line therapy in a kidney-transplanted patient with advanced urothelial carcinoma: a case report

Paola Bordi, Marcello Tiseo, Giorgio Baldari, Sebastiano Buti

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

PNA clamping-assisted fluorescence melting curve analysis for detecting EGFR and KRAS mutations in the circulating tumor DNA of patients with advanced non-small cell lung cancer

Ji-Youn Han, Jae-Jin Choi, Jin Young Kim, You Lim Han, Geon Kook Lee

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Overexpression of KCNJ3 gene splice variants affects vital parameters of the malignant breast cancer cell line MCF-7 in an opposing manner

S. Rezania, S. Kammerer, C. Li, B. Steinecker-Frohnwieser, A. Gorischek, T. T. J. DeVaney, S. Verheyen, C. A. Passegger, N. Ghaffari Tabrizi-Wizsy, H. Hackl, D. Platzer, A. H. Zarnani, E. Malle, S. W. Jahn, T. Bauernhofer, W. Schreibmayer

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

A germline mutation of CDKN2A and a novel RPLP1-C19MC fusion detected in a rare melanotic neuroectodermal tumor of infancy: a case report

David J. Barnes, Edward Hookway, Nick Athanasou, Takeshi Kashima, Udo Oppermann, Simon Hughes, Daniel Swan, Dietrich Lueerssen, John Anson, A. Bassim Hassan

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Young patients and gastrointestinal (GI) tract malignancies - are we addressing the unmet needs?

G. Perl, S. Nordheimer, S. Lando, C. Benedict, B. Brenner, S. Perry, G. Shmoisman, O. Purim, L. Amit, S. M. Stemmer, I. Ben-Aharon

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Which is better for gastric cancer patients, perioperative or adjuvant chemotherapy: a meta-analysis

Jun-hua Zhao, Peng Gao, Yong-xi Song, Jing-xu Sun, Xiao-wan Chen, Bin Ma, Yu-chong Yang, Zhen-ning Wang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Prognostic relevance of molecular subtypes and master regulators in pancreatic ductal adenocarcinoma

Rekin’s Janky, Maria Mercedes Binda, Joke Allemeersch, Anke Van den broeck, Olivier Govaere, Johannes V. Swinnen, Tania Roskams, Stein Aerts, Baki Topal

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Metformin use and its effect on survival in diabetic patients with advanced non-small cell lung cancer

Oscar Arrieta, Edgar Varela-Santoyo, Enrique Soto-Perez-de-Celis, Roberto Sánchez-Reyes, Martha De la Torre-Vallejo, Saé Muñiz-Hernández, Andrés F. Cardona

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

A case report of a patient with metastatic ocular melanoma who experienced a response to treatment with the BRAF inhibitor vemurafenib

A. Maleka, G. Åström, P. Byström, G. J. Ullenhag

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The usefulness of 18F-FDG PET/CT for assessing methotrexate-associated lymphoproliferative disorder (MTX-LPD)

Shiro Watanabe, Osamu Manabe, Kenji Hirata, Noriko Oyama-Manabe, Naoya Hattori, Yasuka Kikuchi, Kentaro Kobayashi, Takuya Toyonaga, Nagara Tamaki