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Pathology & Oncology Research

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01.04.2015 | Research

Lantana camara Induces Apoptosis by Bcl-2 Family and Caspases Activation

verfasst von: Eun Byeol Han, Bo Yoon Chang, Young Suk Jung, Sung Yeon Kim

Erschienen in: Pathology & Oncology Research | Ausgabe 2/2015

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Abstract

Breast cancer is one of the most common cancers worldwide, and the second most fatal cancer in women after lung cancer. Because there are instances of cancer resistance to existing therapies, studies focused on the identification of novel therapeutic drugs are very important. In this study, we identified a natural anticancer agent from Lantana camara, a flowering plant species of the genus Verbena. The extract obtained from the L. camara exhibited cell death properties in the human breast cancer cell line, MCF-7. We found that the apoptosis induced by treatment with the L. camara extract was regulated by the Bcl-2 family. Bid and Bax was increased and Bcl-2 was decreased by L. camara extract. L. camara extract modulated cleavage of caspase-8, and caspase-9, as well as poly (ADP-ribose) polymerase (PARP). Our results support the potential use of the L. camara extract as an anti-breast cancer drug.

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Titel: Lantana camara Induces Apoptosis by Bcl-2 Family and Caspases Activation
verfasst von: Eun Byeol Han
Bo Yoon Chang
Young Suk Jung
Sung Yeon Kim
Publikationsdatum: 01.04.2015
Verlag: Springer Netherlands
Erschienen in: Pathology & Oncology Research / Ausgabe 2/2015
Print ISSN: 1219-4956
Elektronische ISSN: 1532-2807
DOI: https://doi.org/10.1007/s12253-014-9824-4

Springer Medizin

Lantana camara Induces Apoptosis by Bcl-2 Family and Caspases Activation

Abstract

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Springer Medizin

Abstract

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