Erschienen in:
01.08.2015 | Letter to the Editor
Lean Body Weight Is Not a Weight Scalar for Estimating Drug Doses in Morbid Obesity
verfasst von:
John H. P. Friesen
Erschienen in:
Obesity Surgery
|
Ausgabe 8/2015
Einloggen, um Zugang zu erhalten
Excerpt
In their recent review article “Controversies in Perioperative Anesthetic Management of the Morbidly Obese: I Am a Surgeon, Why Should I Care?”, Sinha and Singh [
1] mention lean body weight as one of the weight scalars that may be appropriate when adjusting drug doses for morbid obesity. Lean body weight correlates with drug clearance [
2], cardiac output [
3], and blood volume [
4]. It is therefore frequently useful when estimating drug doses for morbidly obese patients [
5]. Nevertheless, it cannot be used without modification. Any weight scalar must not only be proportional to the required doses, but must also equal total body weight for non-obese patients. Because lean body weight is always less than total body weight (by the amount of the fat mass), it must be scaled upwards to avoid under dosing [
6]. …