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Seminars in Immunopathology

Erschienen in:

09.03.2020 | Review

Leishmaniasis immunopathology—impact on design and use of vaccines, diagnostics and drugs

verfasst von: Paul M. Kaye, Israel Cruz, Albert Picado, Katrien Van Bocxlaer, Simon L. Croft

Erschienen in: Seminars in Immunopathology | Ausgabe 3/2020

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Abstract

Leishmaniasis is a disease complex caused by 20 species of protozoan parasites belonging to the genus Leishmania. In humans, it has two main clinical forms, visceral leishmaniasis (VL) and cutaneous or tegumentary leishmaniasis (CL), as well as several other cutaneous manifestations in a minority of cases. In the mammalian host Leishmania parasites infect different populations of macrophages where they multiply and survive in the phagolysosomal compartment. The progression of both VL and CL depends on the maintenance of a parasite-specific immunosuppressive state based around this host macrophage infection. The complexity and variation of immune responses and immunopathology in humans and the different host interactions of the different Leishmania species has an impact upon the effectiveness of vaccines, diagnostics and drugs.

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Titel: Leishmaniasis immunopathology—impact on design and use of vaccines, diagnostics and drugs
verfasst von: Paul M. Kaye
Israel Cruz
Albert Picado
Katrien Van Bocxlaer
Simon L. Croft
Publikationsdatum: 09.03.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Seminars in Immunopathology / Ausgabe 3/2020
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-020-00788-y

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