Introduction
Materials and methods
Clinical sample collection
Parameter | Category | n |
---|---|---|
Gender | Male | 28 |
Female | 16 | |
Age (years) | <60 | 26 |
≥60 | 18 | |
Diameter (cm) | <4 | 33 |
≥4 | 11 | |
Position | Head | 31 |
Body and tail | 12 | |
Differentiation | Well | 9 |
Moderate | 25 | |
Poor | 10 | |
TNM stage | I or II | 20 |
III or IV | 24 | |
Node status | Negative | 24 |
Positive | 20 |
Immunohistochemistry
Quantitative real-time PCR (qRT-PCR)
Statistical analysis
Results
HOXB7 mRNA was over-expressed in PDAC samples
Parameter | HOXB7 protein | HOXB7 mRNA | miR-337 | ||||
---|---|---|---|---|---|---|---|
Negative (n) | Positive (n) | P value | Expression level | P value | Expression level | P value | |
Gender | |||||||
Male | 10 | 18 | 0.764 | 1.319 ± 0.221 | 0.795 | 0.2900 ± 0.09854 | 0.860 |
Female | 5 | 11 | 1.302 ± 0.218 | 0.2981 ± 0.08573 | |||
Age (years) | |||||||
<60 | 9 | 17 | 0.930 | 1.296 ± 0.229 | 0.631 | 0.306 ± 0.105 | 0.132 |
≥60 | 6 | 12 | 1.338 ± 0.203 | 0.274 ± 0.072 | |||
Diameter(cm) | |||||||
<4 | 14 | 19 | 0.043* | 1.259 ± 0.219 | 0.033* | 0.305 ± 0.097 | 0.228 |
≥4 | 1 | 10 | 1.474 ± 0.107 | 0.257 ± 0.072 | |||
Location | |||||||
Head | 12 | 19 | 0.398 | 1.308 ± 0.222 | 0.690 | 0.304 ± 0.095 | 0.521 |
Body or tail | 3 | 9 | 1.325 ± 0.215 | 0.263 ± 0.084 | |||
Differentiation | |||||||
Well | 6 | 3 | 0.009** | 1.221 ± 0.142 | 0.028* | 0.312 ± 0.082 | 0.210 |
Moderate | 9 | 16 | 1.279 ± 0.243 | 0.305 ± 0.102 | |||
Poor | 0 | 10 | 1.481 ± 0.084 | 0.245 ± 0.066 | |||
TNM stage | |||||||
I or II | 11 | 9 | 0.008** | 1.161 ± 0.214 | 0.010* | 0.338 ± 0.109 | 0.002** |
III or IV | 4 | 20 | 1.440 ± 0.117 | 0.256 ± 0.057 | |||
Nodal status | |||||||
Negative | 12 | 12 | 0.015* | 1.199 ± 0.220 | 0.014* | 0.330 ± 0.105 | 0.001** |
Positive | 3 | 17 | 1.450 ± 0.111 | 0.248 ± 0.048 |