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Inflammation Research

Erschienen in:

01.11.2009 | Review

The major inflammatory mediator interleukin-6 and obesity

verfasst von: Katalin Eder, Noemi Baffy, Andras Falus, Andras K. Fulop

Erschienen in: Inflammation Research | Ausgabe 11/2009

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Abstract

Adipose tissue is one of the main sources of inflammatory mediators, with interleukin-6 (IL-6) among them. Although high systemic levels of inflammatory mediators are cachectogenic and/or anorexic, today it is a widely propagated thesis that in the background of obesity, a low level of chronic inflammation can be found, with IL-6 being one of the many suggested mediators. This paper reviews the studies describing elevated IL-6 levels in obese patients and the role of adipocytes and adipose-tissue macrophages in the production of IL-6. The secretion of IL-6 is regulated by several physiologic or pathologic factors: hormones, cytokines, diet, physical activity, stress, hypoxia, and others. Adipose tissue-derived IL-6 may have an effect on metabolism through several mechanisms, including adipose tissue-specific gene expression, triglyceride release, lipoprotein lipase downregulation, insulin sensitivity, and so on. Having a better understanding of these mechanisms may contribute to the prevention and treatment of obesity.

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Titel: The major inflammatory mediator interleukin-6 and obesity
verfasst von: Katalin Eder
Noemi Baffy
Andras Falus
Andras K. Fulop
Publikationsdatum: 01.11.2009
Verlag: SP Birkhäuser Verlag Basel
Erschienen in: Inflammation Research / Ausgabe 11/2009
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI: https://doi.org/10.1007/s00011-009-0060-4

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