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01.08.2003 | Article

Age, body mass index and Type 2 diabetes—associations modified by ethnicity

verfasst von: The DECODE-DECODA Study Group, on behalf of the European Diabetes Epidemiology Group, and the International Diabetes Epidemiology Group

Erschienen in: Diabetologia | Ausgabe 8/2003

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Abstract

Aims/hypothesis

The aim of this study was to assess the effect of ethnicity on the association between age and body mass index as well as the prevalence of diabetes.

Methods

We selected population-based studies carried out after 1980 in the DECODE/A studies representing different ethnic groups: 11 European, 1 Maltese, 3 Indian, 2 Chinese and 3 Japanese surveys. The total numbers of subjects were 14,240 men and 15,129 women who were 30 to 89 years of age. Diabetes was diagnosed according to the 1999 World Health Organization criteria based on a standard 75 g OGTT. Sex-specific prevalence of diabetes by age and BMI was stratified by ethnic group, in particular the interaction of ethnicity on the associations between age/BMI and the prevalence of diabetes.

Results

The prevalence of diabetes was higher in studies from India and Malta compared to Japan, China, and the rest of Europe. The association between BMI and diabetes, adjusted for age, showed noticeable differences between the ethnic groups with an increase in prevalence starting at a BMI between 15 and 20 kg/m² in the Maltese and Indian populations compared to 25 kg/m²in Europeans.

Conclusion/interpretation

The effect of BMI on the age-adjusted prevalence of Type 2 diabetes was modified by ethnicity with considerably lower thresholds in Indian and Maltese subjects compared to those from the rest of Europe. This difference should be reflected in national and international recommendations regarding "optimal" BMI.

Nur mit Berechtigung zugänglich

Neel JV (1962) Diabetes mellitus "thrifty" genotype rendered detrimental by "process"? Am J Hum Genet 14:353–362

King H, Rewers M, WHO AD HOC Diabetes Reporting Group (1993) Global estimates for prevalence of diabetes mellitus and impaired glucose tolerance in adults. Diabetes Care 16:157–177PubMed

Midthjell K, Knuger Ø, Holmen J et al. (1999) Rapid change in the prevalence of obesity and known diabetes in an adult Norwegian population. The third-Trøndelag Health Surveys: 1984–1986 and 1995–1997. Diabetes Care 22:1813–1820PubMed

Fujimoto WY, Leonetti DL, Kinyoun JL et al. (1987) Prevalence of diabetes mellitus and impaired glucose tolerance among second-generation Japanese-American men. Diabetes 36:721–729PubMed

Omar MA, Seedat MA, Dyer RB, Motala AA, Knight LT, Becker PJ (1994) South African Indians show a high prevalence of NIDDM and bimodality in plasma glucose distribution patterns. Diabetes Care 17:70–73PubMed

Haffner SM, Stern MP, Mitchell BD, Hazuda HP, Patterson JK (1990) Incidence of type II diabetes in Mexican Americans predicted by fasting insulin and glucose levels, obesity, and body-fat distribution. Diabetes 39:283–288PubMed

Everhart JE, Pettitt DJ, Bennett PH, Knowler WC (1992) Duration of obesity increases the incidence of NIDDM. Diabetes 41:235–240PubMed

Colditz GA, Willett WC, Rotnitzky A, Manson JE (1995) Weight gain as a risk factor for clinical diabetes mellitus in women. Ann Intern Med 122:481–486PubMed

DECODE Study Group on behalf of the European Diabetes Epidemiology Study Group (1998) Will new diagnostic criteria for diabetes mellitus change phenotype of patients with diabetes? Reanalysis of European epidemiological data. BMJ 317:371–375PubMed

10.

DECODA Study Group on behalf of the International Diabetes Epidemiology Group (2000) Comparison of the fasting and the 2-hour glucose criteria for diabetes in different Asian cohorts. Diabetologia 43:1470–1475

11.

World Health Organization Expert Committee (1980) Diabetes Mellitus: Second report. WHO Technical Report Series, No. 646, WHO, Geneva

12.

Stegmayr B, Asplund K (1995) Diabetes as a risk factor for stroke. A population perspective. Diabetologia 38:1061–1068CrossRefPubMed

13.

Skarfors ET, Selinus KI, Lithell HO (1991) Risk factors for developing non-insulin dependent diabetes: a 10 year follow up of men in Uppsala. BMJ 303:755–760PubMed

14.

Pyorala K, Savolainen E, Lehtovirta E, Punsar S, Siltanen P (1979) Glucose tolerance and coronary heart disease: Helsinki policemen study. Glucose tolerance and coronary heart disease: Helsinki policemen study. J Chronic Dis. 32:729–745

15.

Garancini MP, Calori G, Ruotolo G et al. (1995) Prevalence of NIDDM and impaired glucose tolerance in Italy: an OGTT-based population study. Diabetologia 38:306–313CrossRefPubMed

16.

Vartiainen E, Puska P, Jousilahti P, Korhonen HJ, Tuomilehto J, Nissinen A (1994) Twenty-year trends in coronary risk factors in north Karelia and in other areas of Finland. Int J Epidemiol 23:495–504PubMed

17.

Stengard JH, Pekkanen J, Tuomilehto J et al. (1993) Changes in glucose tolerance among elderly Finnish men during a five-year follow-up: the Finnish cohorts of the Seven Countries Study. Diabet Metab19:121–129

18.

Schranz A, Tuomilehto J, Marti B, Jarrett RJ, Grabauskas V, Vassallo A (1991) Low physical activity and worsening of glucose tolerance: results from a 2-year follow-up of a population sample in Malta. Diabetes Res Clin Pract 11:127–136PubMed

19.

Mohan V, Shanthi Rani CS, Deepa R, Premalatha G, Sastry NG, Saroja R (2001) Intra urban differences in the prevalence of metabolic syndrome in southern India—The Chennai Urban Population Study (CUPS). Diabet Med 18:280–287CrossRefPubMed

20.

Ramachandran A, Snehalatha C, Latha E, Vijay V, Viswanathan M (1997) Rising prevalence of NIDDM in an urban population in India. Diabetologia 40:232–237CrossRefPubMed

21.

Iyer SR, Iyer RR, Upasani SV, Baitule MN (2001) Diabetes mellitus in Dombivli—an urban population study. J Assoc Physicians India 49:713–716PubMed

22.

Ohmura T, Ueda K, Kiyohara Y et al. (1993) Prevalence of Type 2 (non-insulin-dependent) diabetes mellitus and impaired glucose tolerance in the Japanese general population: the Hisayama study. Diabetologia 36:1198–1203PubMed

23.

Nagai M, Sakata K, Yanagawa H, Sueta H, Tanaka T, Shirahama S (1992) The prevalence of diabetes mellitus and impaired glucose tolerance studies by 75-gram oral glucose tolerance test in a rural island population. Japanese Journal of Public Health 39:907–912PubMed

24.

Sekikawa A, Tominaga M, Takahashi K et al. (1993) Prevalence of diabetes and impaired glucose tolerance in Funagata area, Japan. Diabetes Care 16:570–574PubMed

25.

DECODE Study Group on behalf of the European Diabetes Epidemiology Study Group (2003). Age- and sex- specific prevalence of diabetes and impaired glucose regulation in 13 European cohorts. Diabetes Care 26:61–69PubMed

26.

World Health Organization (1999) Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. Report of a WHO Consultation, Part1: Diagnosis and Classification of Diabetes Mellitus. WHO, Geneva (WHO/NCD/NCS/99.2)

27.

Abate N, Chandalia M (2001) Ethnicity and type 2 diabetes: focus on Asian Indians. J Diabetes Complications 15:320–327CrossRefPubMed

28.

Despres JP, Nadeau A, Tremblay A et al. (1989) Role of deep abdominal fat in the association between regional adipose tissue distribution and glucose tolerance in obese women. Diabetes 38:304–309PubMed

29.

Abate N, Garg A, Pershock RM, Stray-Gundersen J, Grundy SM (1995) Relationships of generalized and regional adiposity to insulin sensitivity in men. J Clin Invest 96:88–98PubMed

30.

Goodpaster BH, Thaete FL, Simoneau JA, Kelley DE (1997) Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes 46:1579–1585PubMed

31.

Mckeigue PM, Pierpoint T, Ferrie JE, Marmont MG (1992) Relationship of glucose intolerance and hyperinsulinemia to body fat pattern in South Asians and Europeans. Diabetologia 35:785–791PubMed

32.

Karter AJ, Mayer-Davis EJ, Selby JV et al. (1996) Insulin sensitivity and abdominal obesity in African-American, Hispanic, and non-Hispanic white men and women. The Insulin Resistance and Atherosclerosis Study. Diabetes 45:1547–1555PubMed

33.

Wang J, Thornton JC, Russel M, Burastero S, Heymsfield S (1994) Asians have lower body mass index (BMI) but higher percent body fat than do whites: comparisons of anthropometric measurements. Am J Clin Nutr 60:23–28PubMed

34.

Yajnik CS, Fall CHD, Vaidya U et al. (1995) Fetal growth and glucose and insulin metabolism in four-year-old Indian children. Diabet Med 12:330–336PubMed

35.

Barker DJP, Hales CN, Fall CHD, Osmond C, Phipps K, Clark PMS (1993) Type2 (non-insulin dependent) diabetes mellitus, hypertension and hyperlipidemia (syndrome X): relation to reduced fetal growth. Diabetologia 36:62–67PubMed

36.

Matsumoto K, Miyake S, Yano M et al. (1997) Glucose tolerance, insulin secretion, and insulin sensitivity in nonobese and obese Japanese subjects. Diabetes Care 20:1562–1568PubMed

37.

Regional Office for the Western Pacific of the World Health Organization, International Association for the Study of Obesity and the International Obesity Task Force (2000) The Asia-Pacific perspective: Redefining obesity and its treatment. (http://www.obesityasiapacific.com/) Health Communications Australia:22–29

38.

Norgan NG (1994) Population differences in body composition in relation to body mass index. Eur J Clin Nutr 48 (Suppl):10–27

39.

Deurenberg P, Deurenberg Yap M, Wang J, Lin FP, Schmidt G (1999) The impact of body build on the relationship between body mass index and percent body fat. Int J Obes Relat Metab Disord 23:537–542CrossRefPubMed

40.

Yokoyama H, Okudaira M, Otani T et al. (1998) High incidence of diabetic nephropathy in early-onset Japanese NIDDM patients. Diabetes Care 21:1080–1085PubMed

41.

Pan XR, Li GW, Hu YH et al. (1997) Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and diabetes study. Diabetes Care 20:537–544PubMed

42.

Eriksson KF, Lindgärde F (1991) Prevention of Type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise. The 6-year Malmö feasibility study. Diabetologia 34:891–898PubMed

43.

Tuomilehto J, Lindström J, Eriksson JG et al. (2001) Prevention of Type 2 diabetes by changes in lifestyle among subjects with impaired glucose tolerance. N Eng J Med 344:1343–1350CrossRef

Titel: Age, body mass index and Type 2 diabetes—associations modified by ethnicity
verfasst von: The DECODE-DECODA Study Group
on behalf of the European Diabetes Epidemiology Group
and the International Diabetes Epidemiology Group
Publikationsdatum: 01.08.2003
Verlag: Springer-Verlag
Erschienen in: Diabetologia / Ausgabe 8/2003
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-003-1158-9

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Age, body mass index and Type 2 diabetes—associations modified by ethnicity