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Diabetologia

Erschienen in:

01.01.2005 | Article

Characterisation of subjects with early abnormalities of glucose tolerance in the Stockholm Diabetes Prevention Programme: the impact of sex and type 2 diabetes heredity

verfasst von: J. Kuhl, A. Hilding, C. G. Östenson, V. Grill, S. Efendic, P. Båvenholm

Erschienen in: Diabetologia | Ausgabe 1/2005

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Abstract

Aims/hypothesis

We evaluated the impact of sex and type 2 diabetes heredity on the prevalence and pathogenesis of early abnormalities of glucose homeostasis in subjects participating in the Stockholm Diabetes Prevention Programme.

Methods

A sample of 3,128 men and 4,821 women, of whom approximately half had a family history of type 2 diabetes (FHD) was categorised according to an OGTT: NGT, IFG, IGT, combined glucose intolerance and type 2 diabetes. The homeostasis model assessment was used to determine insulin sensitivity and beta cell function.

Results

Prevalence of early abnormalities of glucose metabolism was two to three times higher in subjects with FHD and two to three times higher in men compared to women. Both maternal and paternal heredity of type 2 diabetes were associated with an increased risk of having early abnormalities of glucose metabolism. However, in women with type 2 diabetes heredity on the father’s side seems to have less impact on an increased risk of having type 2 diabetes. Both waist circumference and systolic blood pressure were increased in subjects with abnormalities of glucose homeostasis, whereas insulin sensitivity and beta cell function were decreased. Subjects with IFG had more pronounced impairment of beta cell function and insulin sensitivity than subjects with IGT.

Conclusion/interpretation

An FHD and male sex increased the prevalence of abnormalities of glucose homeostasis. Subjects with IFG had more pronounced defects of insulin secretion and action than subjects with IGT.

Unwin N, Shaw J, Zimmet P, Alberti KG (2002) Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention. Diabet Med 19:708–723CrossRefPubMed

Köbberling J, Tillil H (1982) Empirical risk figures for first-degree relatives of non-insulin dependent diabetics. In: Köbberling J, Tattersall R (eds) The genetics of diabetes mellitus. Academic Press, London, pp 201–209

de Vegt F, Dekker JM, Stehouwer CD, Nijpels G, Bouter LM, Heine RJ (1998) The 1997 American Diabetes Association criteria versus the 1985 World Health Organization criteria for the diagnosis of abnormal glucose tolerance: poor agreement in the Hoorn Study. Diabetes Care 21:1686–1690PubMed

DECODE (1999) Glucose tolerance and mortality: comparison of WHO and American Diabetes Association diagnostic criteria. The DECODE study group. European Diabetes Epidemiology Group. Diabetes epidemiology: collaborative analysis of diagnostic criteria in Europe. Lancet 354:617–621

Hanefeld M, Koehler C, Fuecker K, Henkel E, Schaper F, Temelkova-Kurktschiev T (2003) Insulin secretion and insulin sensitivity pattern is different in isolated impaired glucose tolerance and impaired fasting glucose: the risk factor in impaired glucose tolerance for atherosclerosis and diabetes study. Diabetes Care 26:868–874PubMed

Tripathy D, Carlsson M, Almgren P et al (2000) Insulin secretion and insulin sensitivity in relation to glucose tolerance: lessons from the Botnia Study. Diabetes 49:975–980PubMed

Jensen CC, Cnop M, Hull RL, Fujimoto WY, Kahn SE (2002) Beta-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the U.S. Diabetes 51:2170–2178PubMed

Carnevale Schianca GP, Rossi A, Sainaghi PP, Maduli E, Bartoli E (2003) The significance of impaired fasting glucose versus impaired glucose tolerance: importance of insulin secretion and resistance. Diabetes Care 26:1333–1337PubMed

Carlsson S, Persson PG, Alvarsson, M et al (1998) Weight history, glucose intolerance, and insulin levels in middle-aged Swedish men. Am J Epidemiol 148:539–545PubMed

10.

Carlsson S, Persson PG, Alvarsson M et al (1999) Low birth weight, family history of diabetes, and glucose intolerance in Swedish middle-aged men. Diabetes Care 22:1043–1047PubMed

11.

Grill V, Persson G, Carlsson S et al (1999) Family history of diabetes in middle-aged Swedish men is a gender unrelated factor which associates with insulinopenia in newly diagnosed diabetic subjects. Diabetologia 42:15–23

12.

Agardh EE, Ahlbom A, Andersson T et al (2003) Work stress and low sense of coherence is associated with type 2 diabetes in middle-aged Swedish women. Diabetes Care 26:719–724PubMed

13.

WHO (1985) Diabetes mellitus. Report of a WHO Study Group. WHO Tech Rep Ser 727:1–113

14.

Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (1997) Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 20:1183–1197

15.

Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412–419PubMed

16.

Herbert V, Lau KS, Gottlieb CW, Bleicher SJ (1965) Coated charcoal immunoassay of insulin. J Clin Endocrinol Metab 25:1375–1384PubMed

17.

Group DS (2003) Age- and sex-specific prevalences of diabetes and impaired glucose regulation in 13 European cohorts. Diabetes Care 26:61–69PubMed

18.

Groop L, Forsblom C, Lehtovirta M et al (1996) Metabolic consequences of a family history of NIDDM (the Botnia study). Diabetes 45:1585–1593PubMed

19.

Hanley AJ, D’Agostino R Jr, Wagenknecht LE et al (2002) Increased proinsulin levels and decreased acute insulin response independently predict the incidence of type 2 diabetes in the insulin resistance atherosclerosis study. Diabetes 51:1263–1270PubMed

20.

Haffner SM, Mykkinän L, Valdez R et al (1994) Disproportionately increased proinsulin levels are associated with the insulin resistance syndrome. J Clin Endocrinol Metab 79:1806–1810

21.

Zethelius B, Byberg L, Hales CN, Lithell H, Berne C (2002) Proinsulin is an independent predictor of coronary heart disease: report from a 27-year follow-up study. Circulation 105:2153–2158CrossRefPubMed

22.

Nagi DK, Hendra TJ, Ryle AJ et al (1990) The relationship of concentrations of insulin, intact proinsulin and 32–33 split proinsulin with cardiovascular risk factors in type 2 (non-insulin-dependent) diabetic subjects. Diabetologia 33:532–537PubMed

23.

Lindahl B, Dinesen B, Eliasson M et al (1999) High proinsulin concentration precedes acute myocardial infarction in a nondiabetic population. Metabolism 48:1197–1202PubMed

24.

Båvenholm P, Karpe F, Proudler A, Tornvall P, Crook D, Hamsten A (1995) Association of insulin and insulin propeptides with an atherogenic lipoprotein phenotype. Metabolism 44:1481–1488PubMed

25.

DeFronzo RA, Ferrannini E, Simonson DC (1989) Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: contributions of excessive hepatic glucose production and impaired tissue glucose uptake. Metabolism 38:387–395PubMed

26.

Haffner SM, Miettinen H, Gaskill SP, Stern MP (1996) Decreased insulin action and insulin secretion predict the development of impaired glucose tolerance. Diabetologia 39:1201–1207PubMed

27.

Båvenholm NP, Pigon J, Östenson C-G, Efendic S (2001) Insulin sensitivity of suppression of endogenous glucose production is the single most important determinator of glucose tolerance. Diabetes 50:1449–1454PubMed

28.

Firth RG, Bell PM, Marsh HM, Hansen I, Rizza RA (1986) Postprandial hyperglycemia in patients with noninsulin-dependent diabetes mellitus. Role of hepatic and extrahepatic tissues. J Clin Invest 77:1525–1532PubMed

29.

Ferrannini E, Bjorkman O, Reichard GAJ et al (1985) The disposal of an oral glucose load in healthy subjects. A quantitative study. Diabetes 34:580–588

Titel: Characterisation of subjects with early abnormalities of glucose tolerance in the Stockholm Diabetes Prevention Programme: the impact of sex and type 2 diabetes heredity
verfasst von: J. Kuhl
A. Hilding
C. G. Östenson
V. Grill
S. Efendic
P. Båvenholm
Publikationsdatum: 01.01.2005
Verlag: Springer-Verlag
Erschienen in: Diabetologia / Ausgabe 1/2005
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-004-1614-1

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Characterisation of subjects with early abnormalities of glucose tolerance in the Stockholm Diabetes Prevention Programme: the impact of sex and type 2 diabetes heredity

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