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01.12.2006 | Article

Lower levels of plasma 25-hydroxyvitamin D among young adults at diagnosis of autoimmune type 1 diabetes compared with control subjects: results from the nationwide Diabetes Incidence Study in Sweden (DISS)

verfasst von: B. Littorin, P. Blom, A. Schölin, H. J. Arnqvist, G. Blohmé, J. Bolinder, A. Ekbom-Schnell, J. W. Eriksson, S. Gudbjörnsdottir, L. Nyström, J. Östman, G. Sundkvist

Erschienen in: Diabetologia | Ausgabe 12/2006

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Abstract

Aims/hypothesis

Low plasma vitamin D concentrations may promote the development of type 1 diabetes. To test this hypothesis, we measured plasma 25-hydroxyvitamin D (25OHD) in young adults with type 1 diabetes.

Methods

The nationwide Diabetes Incidence Study in Sweden (DISS) covers 15- to 34-year-old people with newly diagnosed diabetes. Blood samples at diagnosis were collected during the 2-year period 1987/1988. Patients with islet antibodies (islet cell antibodies, GAD antibodies or tyrosine phosphatase-like protein antibodies) were defined as having autoimmune type 1 diabetes. Plasma 25OHD was measured in samples taken from 459 patients at the time of diagnosis, and in 138 of these subjects 8 years later. The results were compared with age- and sex-matched control subjects (n=208).

Results

At diagnosis, plasma 25OHD levels were significantly lower in patients with type 1 diabetes than in control subjects (82.5±1.3 vs 96.7±2.0 nmol/l; p<0.0001). Eight years later, plasma 25OHD had decreased in patients (81.5±2.6 nmol/l; p=0.04). Plasma 25OHD levels were significantly lower in diabetic men than in diabetic women at diagnosis (77.9±1.4 vs 90.1±2.4 nmol/l; p<0.0001) and at follow-up (77.1±2.8 nmol/l vs 87.2±4.5 nmol/l; p=0.048).

Conclusions/interpretation

The plasma 25OHD level was lower at diagnosis of autoimmune type 1 diabetes than in control subjects, and may have a role in the development of type 1 diabetes. Plasma 25OHD levels were lower in men than in women with type 1 diabetes. This difference may be relevant to the high incidence of type 1 diabetes among young adult men.

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Titel: Lower levels of plasma 25-hydroxyvitamin D among young adults at diagnosis of autoimmune type 1 diabetes compared with control subjects: results from the nationwide Diabetes Incidence Study in Sweden (DISS)
verfasst von: B. Littorin
P. Blom
A. Schölin
H. J. Arnqvist
G. Blohmé
J. Bolinder
A. Ekbom-Schnell
J. W. Eriksson
S. Gudbjörnsdottir
L. Nyström
J. Östman
G. Sundkvist
Publikationsdatum: 01.12.2006
Verlag: Springer-Verlag
Erschienen in: Diabetologia / Ausgabe 12/2006
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-006-0426-x

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Lower levels of plasma 25-hydroxyvitamin D among young adults at diagnosis of autoimmune type 1 diabetes compared with control subjects: results from the nationwide Diabetes Incidence Study in Sweden (DISS)