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01.02.2008 | For Debate

Optimising islet engraftment is critical for successful clinical islet transplantation

verfasst von: O Korsgren, T Lundgren, M Felldin, A Foss, B Isaksson, J Permert, N H Persson, E Rafael, M Rydén, K Salmela, A Tibell, G Tufveson, B Nilsson

Erschienen in: Diabetologia | Ausgabe 2/2008

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Abstract

Clinical islet transplantation is currently being explored as a treatment for persons with type 1 diabetes and hypoglycaemia unawareness. Although ‘proof-of-principle’ has been established in recent clinical studies, the procedure suffers from low efficacy. At the time of transplantation, the isolated islets are allowed to embolise the liver after injection in the portal vein, a procedure that is unique in the area of transplantation. A novel view on the engraftment of intraportally transplanted islets is presented that could explain the low efficacy of the procedure.

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Titel: Optimising islet engraftment is critical for successful clinical islet transplantation
verfasst von: O Korsgren
T Lundgren
M Felldin
A Foss
B Isaksson
J Permert
N H Persson
E Rafael
M Rydén
K Salmela
A Tibell
G Tufveson
B Nilsson
Publikationsdatum: 01.02.2008
Verlag: Springer-Verlag
Erschienen in: Diabetologia / Ausgabe 2/2008
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-007-0868-9

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Optimising islet engraftment is critical for successful clinical islet transplantation

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