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Diabetologia

Erschienen in:

22.08.2018 | Review

SGLT2 inhibitors and mechanisms of cardiovascular benefit: a state-of-the-art review

verfasst von: Subodh Verma, John J. V. McMurray

Erschienen in: Diabetologia | Ausgabe 10/2018

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Abstract

Sodium–glucose cotransporter (SGLT)2 inhibitors have been demonstrated to reduce cardiovascular events, particularly heart failure, in cardiovascular outcome trials. Here, we review the proposed mechanistic underpinnings of this benefit. Specifically, we focus on the role of SGLT2 inhibitors in optimising ventricular loading conditions through their effect on diuresis and natriuresis, in addition to reducing afterload and improving vascular structure and function. Further insights into the role of SGLT2 inhibition in myocardial metabolism and substrate utilisation are outlined. Finally, we discuss two emerging themes: how SGLT2 inhibitors may regulate Na⁺/H⁺ exchange at the level of the heart and kidney and how they may modulate adipokine production. The mechanistic discussion is placed in the context of completed and ongoing trials of SGLT2 inhibitors in the prevention and treatment of heart failure in individuals with and without diabetes.

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Titel: SGLT2 inhibitors and mechanisms of cardiovascular benefit: a state-of-the-art review
verfasst von: Subodh Verma
John J. V. McMurray
Publikationsdatum: 22.08.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Diabetologia / Ausgabe 10/2018
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-018-4670-7

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