Skip to main content
Erschienen in: Pediatric Radiology 2/2010

01.02.2010 | Technical Innovation

Functional analysis in MR urography — made simple

verfasst von: Dmitry Khrichenko, Kassa Darge

Erschienen in: Pediatric Radiology | Ausgabe 2/2010

Einloggen, um Zugang zu erhalten

Abstract

MR urography (MRU) has proved to be a most advantageous imaging modality of the urinary tract in children, providing one-stop comprehensive morphological and functional information, without the utilization of ionizing radiation. The functional analysis of the MRU scan still requires external post-processing using relatively complex software. This has proved to be a limiting factor in widespread routine implementation of MRU functional analysis and use of MRU functional parameters similar to nuclear medicine. We present software, developed in a pediatric radiology department, that not only enables comprehensive automated functional analysis, but is also very user-friendly, fast, easily operated by the average radiologist or MR technician and freely downloadable at www.​chop-fmru.​com. A copy of IDL Virtual Machine is required for the installation, which is obtained at no charge at www.​ittvis.​com. The analysis software, known as “CHOP-fMRU,” has the potential to help overcome the obstacles to widespread use of functional MRU in children.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Avni EF, Bali MA, Regnault M et al (2002) MR urography in children. Eur J Radiol 43:154–166CrossRefPubMed Avni EF, Bali MA, Regnault M et al (2002) MR urography in children. Eur J Radiol 43:154–166CrossRefPubMed
2.
3.
Zurück zum Zitat Cerwinka WH, Grattan-Smith D, Kirsch AJ (2008) Magnetic resonance urography in pediatric urology. J Pediatr Urol 4:74–83CrossRefPubMed Cerwinka WH, Grattan-Smith D, Kirsch AJ (2008) Magnetic resonance urography in pediatric urology. J Pediatr Urol 4:74–83CrossRefPubMed
5.
Zurück zum Zitat Rohrschneider WK, Hoffend J, Becker K et al (2000) Combined static-dynamic MR urography for the simultaneous evaluation of morphology and function in urinary tract obstruction. I. Evaluation of normal status in an animal model. Pediatr Radiol 30:511–522CrossRefPubMed Rohrschneider WK, Hoffend J, Becker K et al (2000) Combined static-dynamic MR urography for the simultaneous evaluation of morphology and function in urinary tract obstruction. I. Evaluation of normal status in an animal model. Pediatr Radiol 30:511–522CrossRefPubMed
6.
Zurück zum Zitat Rohrschneider WK, Becker K, Hoffend J et al (2000) Combined static-dynamic MR urography for the simultaneous evaluation of morphology and function in urinary tract obstruction. II. Findings in experimentally induced ureteric stenosis. Pediatr Radiol 30:523–532CrossRefPubMed Rohrschneider WK, Becker K, Hoffend J et al (2000) Combined static-dynamic MR urography for the simultaneous evaluation of morphology and function in urinary tract obstruction. II. Findings in experimentally induced ureteric stenosis. Pediatr Radiol 30:523–532CrossRefPubMed
7.
Zurück zum Zitat Rohrschneider WK, Haufe S, Wiesel M et al (2002) Functional and morphologic evaluation of congenital urinary tract dilatation by using combined static-dynamic MR urography: findings in kidneys with a single collecting system. Radiology 224:683–694CrossRefPubMed Rohrschneider WK, Haufe S, Wiesel M et al (2002) Functional and morphologic evaluation of congenital urinary tract dilatation by using combined static-dynamic MR urography: findings in kidneys with a single collecting system. Radiology 224:683–694CrossRefPubMed
8.
Zurück zum Zitat McDaniel B, Jones RA, Scherz H et al (2005) Dynamic contrast-enhanced MR urography in the evaluation of pediatric hydronephrosis: part 2, anatomic and functional assessment of ureteropelvic junction obstruction. AJR 185:1608–1614CrossRefPubMed McDaniel B, Jones RA, Scherz H et al (2005) Dynamic contrast-enhanced MR urography in the evaluation of pediatric hydronephrosis: part 2, anatomic and functional assessment of ureteropelvic junction obstruction. AJR 185:1608–1614CrossRefPubMed
9.
Zurück zum Zitat Boss A, Schaefer JF, Martirosian P et al (2006) Contrast-enhanced dynamic MR nephrography using the TurboFLASH navigator-gating technique in children. Eur Radiol 16:1509–1518CrossRefPubMed Boss A, Schaefer JF, Martirosian P et al (2006) Contrast-enhanced dynamic MR nephrography using the TurboFLASH navigator-gating technique in children. Eur Radiol 16:1509–1518CrossRefPubMed
10.
Zurück zum Zitat Jones RA, Easley K, Little SB et al (2005) Dynamic contrast-enhanced MR urography in the evaluation of pediatric hydronephrosis: part I, functional assessment. AJR 185:1598–1607CrossRefPubMed Jones RA, Easley K, Little SB et al (2005) Dynamic contrast-enhanced MR urography in the evaluation of pediatric hydronephrosis: part I, functional assessment. AJR 185:1598–1607CrossRefPubMed
11.
Zurück zum Zitat Slovis TL (2008) Magnetic resonance urography (MRU) course introduction. Pediatr Radiol 38 (Suppl 1):S1-S2 (software distributed to participants of MR urography in children workshop by the Society of Pediatric Radiology, February 24–25, 2007, Orlando, FL) Slovis TL (2008) Magnetic resonance urography (MRU) course introduction. Pediatr Radiol 38 (Suppl 1):S1-S2 (software distributed to participants of MR urography in children workshop by the Society of Pediatric Radiology, February 24–25, 2007, Orlando, FL)
12.
Zurück zum Zitat Merewitz L, Sunshine JH (2006) A portrait of pediatric radiologists in the United States. AJR 186:12–22CrossRefPubMed Merewitz L, Sunshine JH (2006) A portrait of pediatric radiologists in the United States. AJR 186:12–22CrossRefPubMed
13.
14.
Zurück zum Zitat van Rijn RR, Owens CM, Avni F et al (2006) The future of pediatric radiology: a European point of view. Radiology 238:1074CrossRefPubMed van Rijn RR, Owens CM, Avni F et al (2006) The future of pediatric radiology: a European point of view. Radiology 238:1074CrossRefPubMed
15.
Zurück zum Zitat Grattan-Smith JD, Little SB, Jones RA (2008) MR urography in children: how we do it. Pediatr Radiol 38(Suppl 1):S3–S17CrossRefPubMed Grattan-Smith JD, Little SB, Jones RA (2008) MR urography in children: how we do it. Pediatr Radiol 38(Suppl 1):S3–S17CrossRefPubMed
16.
Zurück zum Zitat Leyendecker JR, Barnes CE, Zagoria RJ (2008) MR urography: techniques and clinical applications. Radiographics 28:23–46CrossRefPubMed Leyendecker JR, Barnes CE, Zagoria RJ (2008) MR urography: techniques and clinical applications. Radiographics 28:23–46CrossRefPubMed
17.
Zurück zum Zitat Grattan-Smith JD, Perez-Bayfield MR, Jones RA et al (2003) MR imaging of kidneys: functional evaluation using F-15 perfusion imaging. Pediatr Radiol 33:293–304PubMed Grattan-Smith JD, Perez-Bayfield MR, Jones RA et al (2003) MR imaging of kidneys: functional evaluation using F-15 perfusion imaging. Pediatr Radiol 33:293–304PubMed
18.
Zurück zum Zitat Ergen FB, Hussain HK, Carlos RC et al (2007) 3D excretory MR urography: improved image quality with intravenous saline and diuretic administration. J Magn Reson Imaging 25:783–789CrossRefPubMed Ergen FB, Hussain HK, Carlos RC et al (2007) 3D excretory MR urography: improved image quality with intravenous saline and diuretic administration. J Magn Reson Imaging 25:783–789CrossRefPubMed
19.
Zurück zum Zitat Jones RA, Schmotzer B, Little SB et al (2008) MRU post-processing. Pediatr Radiol 38(Suppl 1):S18–S27CrossRefPubMed Jones RA, Schmotzer B, Little SB et al (2008) MRU post-processing. Pediatr Radiol 38(Suppl 1):S18–S27CrossRefPubMed
20.
Zurück zum Zitat Kalb B, Votaw JR, Salman K et al (2008) Magnetic resonance nephrourography: current and developing techniques. Radiol Clin N Am 46:11–24CrossRefPubMed Kalb B, Votaw JR, Salman K et al (2008) Magnetic resonance nephrourography: current and developing techniques. Radiol Clin N Am 46:11–24CrossRefPubMed
21.
Zurück zum Zitat Grenier N, Mendichovszky I, de Senneville BD et al (2008) Measurement of glomerular filtration rate with magnetic resonance imaging: principles, limitations, and expectations. Semin Nucl Med 38:47–55CrossRefPubMed Grenier N, Mendichovszky I, de Senneville BD et al (2008) Measurement of glomerular filtration rate with magnetic resonance imaging: principles, limitations, and expectations. Semin Nucl Med 38:47–55CrossRefPubMed
22.
Zurück zum Zitat Mendichovszky I, Cutajar M, Gordon I (2009) Reproducibility of the aortic input function (AIF) derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of the kidneys in a volunteer study. Eur J Radiol 71:576--581CrossRefPubMed Mendichovszky I, Cutajar M, Gordon I (2009) Reproducibility of the aortic input function (AIF) derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of the kidneys in a volunteer study. Eur J Radiol 71:576--581CrossRefPubMed
23.
Zurück zum Zitat Grattan-Smith JD, Little SB, Jones RA (2008) MR urography evaluation of obstructive uropathy. Pediatr Radiol 38(Suppl 1):S49–S69CrossRefPubMed Grattan-Smith JD, Little SB, Jones RA (2008) MR urography evaluation of obstructive uropathy. Pediatr Radiol 38(Suppl 1):S49–S69CrossRefPubMed
24.
Zurück zum Zitat Jones RA, Perez-Brayfield MR, Kirsch AJ et al (2004) Renal transit time with MR urography in children. Radiology 233:41–50CrossRefPubMed Jones RA, Perez-Brayfield MR, Kirsch AJ et al (2004) Renal transit time with MR urography in children. Radiology 233:41–50CrossRefPubMed
25.
Zurück zum Zitat Mendichovszky I, Pedersen M, Frokiaer J et al (2008) How accurate is dynamic contrast-enhanced MRI in the assessment of renal glomerular filtration rate? A critical appraisal. J Magn Reson Imaging 27:925–931CrossRefPubMed Mendichovszky I, Pedersen M, Frokiaer J et al (2008) How accurate is dynamic contrast-enhanced MRI in the assessment of renal glomerular filtration rate? A critical appraisal. J Magn Reson Imaging 27:925–931CrossRefPubMed
26.
Zurück zum Zitat Rutland MD (1979) A single-injection technique for subtraction of blood background in 1311-hippuran renograms. Br J Radiol 52:134–137CrossRefPubMed Rutland MD (1979) A single-injection technique for subtraction of blood background in 1311-hippuran renograms. Br J Radiol 52:134–137CrossRefPubMed
27.
Zurück zum Zitat Patlak CS, Blasberg RG, Fenstermacher JD (1983) Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 3:1–7PubMed Patlak CS, Blasberg RG, Fenstermacher JD (1983) Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 3:1–7PubMed
28.
Zurück zum Zitat Peters AM (1994) Graphical analysis of dynamic data: the Patlak-Rutland plot. Nucl Med Commun 15:669–672CrossRefPubMed Peters AM (1994) Graphical analysis of dynamic data: the Patlak-Rutland plot. Nucl Med Commun 15:669–672CrossRefPubMed
29.
Zurück zum Zitat Hackstein N, Kooijman H, Tomaselli S et al (2005) Glomerular filtration rate measured using the Patlak plot technique and contrast-enhanced dynamic MRI with different amounts of gadolinium-DTPA. J Magn Reson Imaging 22:406–414CrossRefPubMed Hackstein N, Kooijman H, Tomaselli S et al (2005) Glomerular filtration rate measured using the Patlak plot technique and contrast-enhanced dynamic MRI with different amounts of gadolinium-DTPA. J Magn Reson Imaging 22:406–414CrossRefPubMed
30.
Zurück zum Zitat Sharkey I, Boddy AV, Wallace H et al (2001) Body surface area estimation in children using weight alone: application in paediatric oncology. Br J Cancer 85:23–28CrossRefPubMed Sharkey I, Boddy AV, Wallace H et al (2001) Body surface area estimation in children using weight alone: application in paediatric oncology. Br J Cancer 85:23–28CrossRefPubMed
Metadaten
Titel
Functional analysis in MR urography — made simple
verfasst von
Dmitry Khrichenko
Kassa Darge
Publikationsdatum
01.02.2010
Verlag
Springer-Verlag
Erschienen in
Pediatric Radiology / Ausgabe 2/2010
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-009-1458-4

Weitere Artikel der Ausgabe 2/2010

Pediatric Radiology 2/2010 Zur Ausgabe

Exposure

Exposure

Mammakarzinom: Brustdichte beeinflusst rezidivfreies Überleben

26.05.2024 Mammakarzinom Nachrichten

Frauen, die zum Zeitpunkt der Brustkrebsdiagnose eine hohe mammografische Brustdichte aufweisen, haben ein erhöhtes Risiko für ein baldiges Rezidiv, legen neue Daten nahe.

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

17.05.2024 Klinik aktuell Nachrichten

Sie sei „ethisch geboten“, meint Gesundheitsminister Karl Lauterbach: mehr Transparenz über die Qualität von Klinikbehandlungen. Um sie abzubilden, lässt er gegen den Widerstand vieler Länder einen virtuellen Klinik-Atlas freischalten.

Klinikreform soll zehntausende Menschenleben retten

15.05.2024 Klinik aktuell Nachrichten

Gesundheitsminister Lauterbach hat die vom Bundeskabinett beschlossene Klinikreform verteidigt. Kritik an den Plänen kommt vom Marburger Bund. Und in den Ländern wird über den Gang zum Vermittlungsausschuss spekuliert.

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.