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Skeletal Radiology
Erschienen in: Skeletal Radiology 6/2010

01.06.2010 | Scientific Article

Longitudinal assessment of bone marrow edema-like lesions and cartilage degeneration in osteoarthritis using 3 T MR T1rho quantification

verfasst von: Jian Zhao, Xiaojuan Li, Radu I. Bolbos, Thomas M. Link, Sharmila Majumdar

Erschienen in: Skeletal Radiology | Ausgabe 6/2010

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Abstract

Objective

To quantitatively assess the relationship between bone marrow edema-like lesions (BMELs) and the associated cartilage in knee osteoarthritis (OA) using T1ρ quantification at 3 T MRI.

Materials and Methods

Twenty-four patients with knee OA and 14 control subjects underwent 3 T MRI. Nineteen patients and all control subjects had 1-year follow-up studies. The volume and signal intensity difference of BMELs were calculated. Cartilage degeneration was graded using the cartilage subscore of Whole-Organ MRI Score (WORMS) analysis. Cartilage T1ρ values were calculated in each compartment as well as in cartilage overlying BMELs (OC) and surrounding cartilage (SC).

Results

At baseline, 25 BMELs were found in 16 out of 24 patients. The overall T1ρ values were significantly higher in patients with BMELs than in those without BMELs. At baseline and follow-up, both T1ρ values and WORMS cartilage subscore grading were significantly higher in OC than SC. Cartilage T1ρ increase from baseline to follow-up in OC was significantly higher than that in SC. An increase in T1ρ values in OC was correlated with signal intensity of BMEL at both baseline and follow-up, but was not correlated with BMEL volume.

Conclusions

The results of this study suggest a local spatial correlation between BMELs and more advanced and accelerated cartilage degeneration. MRI T1ρ quantification in cartilage provides a sensitive tool for evaluating such correlations.
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Metadaten
Titel
Longitudinal assessment of bone marrow edema-like lesions and cartilage degeneration in osteoarthritis using 3 T MR T1rho quantification
verfasst von
Jian Zhao
Xiaojuan Li
Radu I. Bolbos
Thomas M. Link
Sharmila Majumdar
Publikationsdatum
01.06.2010
Verlag
Springer-Verlag
Erschienen in
Skeletal Radiology / Ausgabe 6/2010
Print ISSN: 0364-2348
Elektronische ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-010-0892-6

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