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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.10.2006 | Short communication

In vivo radionuclide uptake quantification using a multi-pinhole SPECT system to predict renal function in small animals

verfasst von: F. Forrer, R. Valkema, B. Bernard, N. U. Schramm, J. W. Hoppin, E. Rolleman, E. P. Krenning, M. de Jong

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 10/2006

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Abstract

Purpose

In vivo quantification of radiopharmaceuticals has great potential as a tool in developing new drugs. We investigated the accuracy of in vivo quantification with multi-pinhole single-photon emission computed tomography (SPECT) in rats.

Methods

Fifteen male Lewis rats with different stages of renal dysfunction were injected with 50 MBq ^99mTc-dimercaptosuccinic acid. Four to six hours after injection, SPECT of the kidneys was acquired with a new four-headed multi-pinhole collimator camera. Immediately after imaging the rats were sacrificed and the kidneys were counted in a gamma-counter to determine the absorbed activity. SPECT data were reconstructed iteratively and regions of interest (ROIs) were drawn manually. The absolute activity in the ROIs was determined.

Results

Uptake values ranging from 0.71% to 21.87% of the injected activity were measured. A very strong linear correlation was found between the determined activity in vivo and ex vivo (r ²=0.946; slope m=1.059).

Conclusion

Quantification in vivo using this multi-pinhole SPECT system is highly accurate.

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Titel: In vivo radionuclide uptake quantification using a multi-pinhole SPECT system to predict renal function in small animals
verfasst von: F. Forrer
R. Valkema
B. Bernard
N. U. Schramm
J. W. Hoppin
E. Rolleman
E. P. Krenning
M. de Jong
Publikationsdatum: 01.10.2006
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 10/2006
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-006-0178-3

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In vivo radionuclide uptake quantification using a multi-pinhole SPECT system to predict renal function in small animals

Abstract

Purpose

Methods

Results

Conclusion

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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