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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.01.2007 | Original article

Value of ¹¹C-choline PET and PET/CT in patients with suspected prostate cancer

verfasst von: Bernhard Scher, Michael Seitz, Wolfram Albinger, Reinhold Tiling, Michael Scherr, Hans-Christoph Becker, Michael Souvatzogluou, Franz-Josef Gildehaus, Hans-Jürgen Wester, Stefan Dresel

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 1/2007

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Abstract

Purpose:

The value and limitations of ¹¹C-choline PET and PET/CT for the detection of prostate cancer remain controversial. The aim of this study was to investigate the diagnostic efficacy of ¹¹C-choline PET and PET/CT in a large group of patients with suspected prostate cancer.

Methods:

Fifty-eight patients with clinical suspicion of prostate cancer underwent ¹¹C-choline PET (25/58, Siemens ECAT Exact HR+) or PET/CT (33/58, Philips Gemini) scanning. On average, 500 MBq of ¹¹C-choline was administered intravenously. Studies were interpreted by raters blinded to clinical information and other diagnostic procedures. Qualitative image analysis as well as semiquantitative SUV measurement was carried out. The reference standard was histopathological examination of resection specimens or biopsy.

Results:

Prevalence of prostate cancer in this selected patient population was 63.8% (37/58). ¹¹C-choline PET and PET/CT showed a sensitivity of 86.5% (32/37) and a specificity of 61.9% (13/21) in the detection of the primary malignancy. With regard to metastatic spread, PET showed a per-patient sensitivity of 81.8% (9/11) and produced no false positive findings.

Conclusion:

Based on our findings, differentiation between benign prostatic changes, such as benign prostatic hyperplasia or prostatitis, and prostate cancer is feasible in the majority of cases when image interpretation is primarily based on qualitative characteristics. SUV_max may serve as guidance. False positive findings may occur due to an overlap of ¹¹C-choline uptake between benign and malignant processes. By providing functional information regarding both the primary malignancy and its metastases, ¹¹C-choline PET may prove to be a useful method for staging prostate cancer.

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Titel: Value of 11C-choline PET and PET/CT in patients with suspected prostate cancer
verfasst von: Bernhard Scher
Michael Seitz
Wolfram Albinger
Reinhold Tiling
Michael Scherr
Hans-Christoph Becker
Michael Souvatzogluou
Franz-Josef Gildehaus
Hans-Jürgen Wester
Stefan Dresel
Publikationsdatum: 01.01.2007
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 1/2007
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-006-0190-7

Springer Medizin

Abstract

Purpose:

Methods:

Results:

Conclusion:

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