Erschienen in:
01.04.2007 | Review Article
Stress-induced abnormalities in myocardial perfusion imaging that are not related to perfusion but are of diagnostic and prognostic importance
verfasst von:
John P. Higgins, Johanna A. Higgins, Gethin Williams
Erschienen in:
European Journal of Nuclear Medicine and Molecular Imaging
|
Ausgabe 4/2007
Einloggen, um Zugang zu erhalten
Abstract
Introduction
Certain stress-induced ancillary findings on myocardial perfusion scintigraphy increase the likelihood that the patient has coronary artery disease (CAD); furthermore, among CAD patients, they indicate more severe and extensive disease, placing these patients at higher risk for future cardiac events. Indeed, in studies with no obvious perfusion defect yet with serious CAD—for example, balanced ischemia—it can be these high-risk findings that necessitate invasive intervention.
Discussion
Besides reversible perfusion defects, such findings include increased pulmonary radiotracer uptake, transient cavity dilatation, increased end-diastolic or end-systolic volume, decreased post-stress ejection fraction, and increased right ventricular tracer uptake on stress images. The pathophysiology underlying these findings is clearly different as they do not always occur together, and each independently predicts more severe and extensive CAD. In the current review, these findings are defined and their significance in diagnosing patients with suspected or known CAD is discussed.