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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.05.2009 | Original Article

Dynamic perfusion patterns in temporal lobe epilepsy

verfasst von: Patrick Dupont, John J. Zaknun, Alex Maes, Supatporn Tepmongkol, Silvia Vasquez, C. S. Bal, Wim Van Paesschen, Silvina Carpintiero, Chaichon Locharernkul, Maurizio Dondi

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 5/2009

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Abstract

Purpose

To investigate dynamic ictal perfusion changes during temporal lobe epilepsy (TLE).

Methods

We investigated 37 patients with TLE by ictal and interictal SPECT. All ictal injections were performed within 60 s of seizure onset. Statistical parametric mapping was used to analyse brain perfusion changes and temporal relationships with injection time and seizure duration as covariates.

Results

The analysis revealed significant ictal hyperperfusion in the ipsilateral temporal lobe extending to subcortical regions. Hypoperfusion was observed in large extratemporal areas. There were also significant dynamic changes in several extratemporal regions: ipsilateral orbitofrontal and bilateral superior frontal gyri and the contralateral cerebellum and ipsilateral striatum.

Conclusion

The study demonstrated early dynamic perfusion changes in extratemporal regions probably involved in both propagation of epileptic activity and initiation of inhibitory mechanisms.

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Titel: Dynamic perfusion patterns in temporal lobe epilepsy
verfasst von: Patrick Dupont
John J. Zaknun
Alex Maes
Supatporn Tepmongkol
Silvia Vasquez
C. S. Bal
Wim Van Paesschen
Silvina Carpintiero
Chaichon Locharernkul
Maurizio Dondi
Publikationsdatum: 01.05.2009
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 5/2009
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-008-1040-6

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Dynamic perfusion patterns in temporal lobe epilepsy

Abstract

Purpose

Methods

Results

Conclusion

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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