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European Journal of Nuclear Medicine and Molecular Imaging

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23.07.2021 | Original Article

Comparison of [⁶⁸ Ga]Ga-FAPI-04 and [¹⁸F]-FDG for the detection of primary and metastatic lesions in patients with gastric cancer: a bicentric retrospective study

verfasst von: Donglang Jiang, Xing Chen, Zhiwen You, Hao Wang, Xiaoyun Zhang, Xiuming Li, Shuhua Ren, Qi Huang, Fengchun Hua, Yihui Guan, Jun Zhao, Fang Xie

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 2/2022

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Abstract

Introduction

The low sensitivity of [¹⁸F]-fluorodeoxyglucose ([¹⁸F]-FDG) for the diagnosis of gastric cancer limits its application. In this study, we aimed to investigate the potential advantage of [⁶⁸ Ga]Ga-FAPI-04 over [¹⁸F]-FDG in the evaluation of gastric cancer.

Methods

This was a bicentric retrospective analysis of a prospective parent study (clinical trial: HS-KY-2020–826 (Huashan Hospital) and DF-2020–102 (Shanghai East Hospital)). Thirty-eight patients with gastric cancer (31 with adenocarcinoma and 7 with signet ring cell carcinoma) were included in this study. All of the participants underwent [⁶⁸ Ga]Ga-FAPI-04 and [¹⁸F]-FDG imaging by positron emission tomography (PET)/computed tomography (CT) or PET/magnetic resonance (MR). The scans were interpreted by two experienced nuclear medicine physicians, and the maximum standardized uptake value (SUV_max) was calculated. Histopathological findings obtained from biopsy or resected surgical specimens were used as a reference for the final diagnosis.

Results

For the detection of primary gastric cancer, the sensitivities of [⁶⁸ Ga]Ga-FAPI-04 PET and [¹⁸F]-FDG PET were 100% (38/38) and 82% (31/38), respectively (P = 0.016). Four cases of adenocarcinoma and three cases of signet ring cell carcinoma were missed by [¹⁸F]-FDG PET. The mean SUV_max of [⁶⁸ Ga]Ga-FAPI-04 in tumours greater than 4 cm (11.0 ± 4.5) was higher than that in tumours less than 4 cm (4.5 ± 3.2) (P = 0.0015). The mean SUV_max of [⁶⁸ Ga]Ga-FAPI-04 was higher in T2–4 tumours (9.7 ± 4.4) than in T1 tumours (3.1 ± 1.5) (P = 0.0002). For the detection of metastatic lesions, the sensitivities of [⁶⁸ Ga]Ga-FAPI-04 PET and [¹⁸F]-FDG PET in 10 patients with regional lymph node metastasis and distant metastasis were 6/10 and 5/10, respectively.

Conclusion

In this selected cohort, [⁶⁸ Ga]Ga-FAPI-04 PET had a superior detection rate than [¹⁸F]-FDG PET for primary gastric cancer. [⁶⁸ Ga]Ga-FAPI-04 PET could provide better performance with regard to gastric cancer diagnosis and staging. Prospective clinical trials are warranted.

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Titel: Comparison of [68 Ga]Ga-FAPI-04 and [18F]-FDG for the detection of primary and metastatic lesions in patients with gastric cancer: a bicentric retrospective study
verfasst von: Donglang Jiang
Xing Chen
Zhiwen You
Hao Wang
Xiaoyun Zhang
Xiuming Li
Shuhua Ren
Qi Huang
Fengchun Hua
Yihui Guan
Jun Zhao
Fang Xie
Publikationsdatum: 23.07.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 2/2022
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-021-05441-w

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Comparison of [⁶⁸ Ga]Ga-FAPI-04 and [¹⁸F]-FDG for the detection of primary and metastatic lesions in patients with gastric cancer: a bicentric retrospective study

Abstract

Introduction

Methods

Results

Conclusion

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

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Abstract

Introduction

Methods

Results

Conclusion

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