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16.11.2022 | Hepatobiliary

Preoperative MRI features for characterization of vessels encapsulating tumor clusters and microvascular invasion in hepatocellular carcinoma

verfasst von: Jiawen Yang, Xue Dong, Guanliang Wang, Jinyao Chen, Binhao Zhang, Wenting Pan, Huangqi Zhang, Shengze Jin, Wenbin Ji

Erschienen in: Abdominal Radiology | Ausgabe 2/2023

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Abstract

Purpose

This study aimed to analyze imaging features based on preoperative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for the identification of vessels encapsulating tumor clusters (VETC)-microvascular invasion (MVI) in hepatocellular carcinoma (HCC), VM-HCC pattern.

Methods

Patients who underwent hepatectomy and preoperative DCE-MRI between January 2015 and March 2021 were retrospectively analyzed. Clinical and imaging features related to VM-HCC (VETC + /MVI-, VETC-/MVI +, VETC + /MVI +) and Non-VM-HCC (VETC-/MVI-) were determined by multivariable logistic regression analyses. Early and overall recurrence were determined using the Kaplan–Meier survival curve. Indicators of early and overall recurrence were identified using the Cox proportional hazard regression model.

Results

In total, 221 patients (177 men, 44 women; median age, 60 years; interquartile range, 52–66 years) were evaluated. The multivariable logistic regression analyses revealed fetoprotein > 400 ng/mL (odds ratio [OR] = 2.17, 95% confidence interval [CI] 1.07, 4.41, p = 0.033), intratumor vascularity (OR 2.15, 95% CI 1.07, 4.31, p = 0.031), and enhancement pattern (OR 2.71, 95% CI 1.17, 6.03, p = 0.019) as independent predictors of VM-HCC. In Kaplan–Meier survival analysis, intratumor vascularity was associated with early and overall recurrence (p < 0.05).

Conclusion

Based on DCE-MRI, intratumor vascularity can be used to characterize VM-HCC and is of prognostic significance for recurrence in patients with HCC.

Graphical abstract

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Titel: Preoperative MRI features for characterization of vessels encapsulating tumor clusters and microvascular invasion in hepatocellular carcinoma
verfasst von: Jiawen Yang
Xue Dong
Guanliang Wang
Jinyao Chen
Binhao Zhang
Wenting Pan
Huangqi Zhang
Shengze Jin
Wenbin Ji
Publikationsdatum: 16.11.2022
Verlag: Springer US
Erschienen in: Abdominal Radiology / Ausgabe 2/2023
Print ISSN: 2366-004X
Elektronische ISSN: 2366-0058
DOI: https://doi.org/10.1007/s00261-022-03740-w

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Preoperative MRI features for characterization of vessels encapsulating tumor clusters and microvascular invasion in hepatocellular carcinoma