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Cancer Immunology, Immunotherapy

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01.04.2021 | Original Article

Assessment of systematic inflammatory and nutritional indexes in extensive-stage small-cell lung cancer treated with first-line chemotherapy and atezolizumab

verfasst von: Wei-Xiang Qi, Yi Xiang, Shengguang Zhao, Jiayi Chen

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 11/2021

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Abstract

Background

The present study aims to investigate the prognostic role of systematic inflammatory and nutritional indexes in extensive-stage small-cell lung cancer (ES-SCLC) treated with first-line chemotherapy and atezolizumab.

Materials and methods

Prospective cohort population involving 53 patients were identified from NCT03041311 trial. The following peripheral blood-derived inflammatory and nutritional indexes, including neutrophil–lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), lymphocyte–monocyte ratio (LMR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), prognostic nutrition index (PNI), advanced lung cancer inflammation index (ALI), and lung immune prognostic index (LIPI) were evaluated.

Results

The optimal cut-off values of the ALI, LMR, NLR, PLR, PNI, SII and SIRI were 323.23, 2.73, 2.57, 119.23, 48, 533.28 and 2.32, respectively. With a median follow-up of 17.1 months, the 1-year OS and PFS were 56% and 8%, respectively. Multivariate analysis showed that PLR was the only independent prognostic factors for OS among ES-SCLC patients treated with chemotherapy and atezolizumab (HR 4.63, 95%CI: 1.00–21.46, p = 0.05). K-M analysis showed that the OS and PFS for patients with high PLR (> 119.23) were significantly poorer than these with low PLR (≤ 119.23) (p = 0.0004 for OS and p = 0.014 for PFS). In external validation set, prognosis of patients with high PLR was also significantly poorer than these with low PLR in terms of OS (p = 0.038) and PFS (p = 0.028).

Conclusion

Pre-treatment PLR could serve as a valuable independent prognostic factor for ES-SCLC who receive chemotherapy and immune checkpoint inhibitors. Further, prospective studies are still needed to confirm our findings.

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Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68(6):394–424CrossRefPubMed

Wang S, Zimmermann S, Parikh K, Mansfield AS, Adjei AA (2019) Current diagnosis and management of small-cell lung cancer. Mayo Clin Proc 94(8):1599–1622PubMedCrossRef

Byers LA, Rudin CM (2015) Small cell lung cancer: where do we go from here? Cancer 121(5):664–672PubMedCrossRef

Roth BJ, Johnson DH, Einhorn LH, Schacter LP, Cherng NC, Cohen HJ, Crawford J, Randolph JA, Goodlow JL, Broun GO et al (1992) Randomized study of cyclophosphamide, doxorubicin, and vincristine versus etoposide and cisplatin versus alternation of these two regimens in extensive small-cell lung cancer: a phase III trial of the Southeastern Cancer study group. J Clin Oncol Off J Am Soc Clin Oncol 10(2):282–291CrossRef

Sundstrom S, Bremnes RM, Kaasa S, Aasebo U, Hatlevoll R, Dahle R, Boye N, Wang M, Vigander T, Vilsvik J et al (2002) Cisplatin and etoposide regimen is superior to cyclophosphamide, epirubicin, and vincristine regimen in small-cell lung cancer: results from a randomized phase III trial with 5 years’ follow-up. J Clin Oncol Off J Am Soc Clin Oncol 20(24):4665–4672CrossRef

Horn L, Reck M, Spigel DR (2016) The future of immunotherapy in the treatment of small cell lung cancer. Oncologist 21(8):910–921PubMedPubMedCentralCrossRef

Rudin CM, Ismaila N, Hann CL, Malhotra N, Movsas B, Norris K, Pietanza MC, Ramalingam SS, Turrisi AT 3rd, Giaccone G (2015) Treatment of small-cell lung cancer: American society of clinical oncology endorsement of the American college of chest physicians guideline. J Clin Oncol Off J Am Soc Clin Oncol 33(34):4106–4111CrossRef

George J, Lim JS, Jang SJ, Cun Y, Ozretic L, Kong G, Leenders F, Lu X, Fernandez-Cuesta L, Bosco G et al (2015) Comprehensive genomic profiles of small cell lung cancer. Nature 524(7563):47–53PubMedPubMedCentralCrossRef

Horn L, Mansfield AS, Szczesna A, Havel L, Krzakowski M, Hochmair MJ, Huemer F, Losonczy G, Johnson ML, Nishio M et al (2018) First-line Atezolizumab plus chemotherapy in extensive-stage small-cell lung cancer. N Engl J Med 379(23):2220–2229PubMedCrossRef

10.

Paz-Ares L, Dvorkin M, Chen Y, Reinmuth N, Hotta K, Trukhin D, Statsenko G, Hochmair MJ, Ozguroglu M, Ji JH et al (2019) Durvalumab plus platinum-etoposide versus platinum-etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial. Lancet 394(10212):1929–1939PubMedCrossRef

11.

Reck M, Bondarenko I, Luft A, Serwatowski P, Barlesi F, Chacko R, Sebastian M, Lu H, Cuillerot JM, Lynch TJ (2013) Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: results from a randomized, double-blind, multicenter phase 2 trial. Annal Oncol Off J Eur Soc Med Oncol ESMO 24(1):75–83CrossRef

12.

Chen HL, Tu YK, Chang HM, Lee TH, Wu KL, Tsai YC, Lee MH, Yang CJ, Hung JY, Chong IW (2020) Systematic review and network meta-analysis of immune checkpoint inhibitors in combination with chemotherapy as a first-line therapy for extensive-stage small cell carcinoma. Cancers. https://doi.org/10.3390/cancers12123629CrossRefPubMedPubMedCentral

13.

Iams WT, Porter J, Horn L (2020) Immunotherapeutic approaches for small-cell lung cancer. Nat Rev Clin Oncol 17(5):300–312PubMedPubMedCentralCrossRef

14.

Suresh K, Naidoo J, Lin CT, Danoff S (2018) Immune checkpoint immunotherapy for non-small cell lung cancer: benefits and pulmonary toxicities. Chest 154(6):1416–1423PubMedPubMedCentralCrossRef

15.

Mandaliya H, Jones M, Oldmeadow C, Nordman II (2019) Prognostic biomarkers in stage IV non-small cell lung cancer (NSCLC): neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), platelet to lymphocyte ratio (PLR) and advanced lung cancer inflammation index (ALI). Transl Lung Cancer Res 8(6):886–894PubMedPubMedCentralCrossRef

16.

Kobayashi S, Karube Y, Inoue T, Araki O, Maeda S, Matsumura Y, Chida M (2019) Advanced lung cancer inflammation index predicts outcomes of patients with pathological stage IA lung adenocarcinoma following surgical resection. Annal Thorac Cardiovasc Surg Off J Assoc Thorac Cardiovasc Surg Asia 25(2):87–94

17.

Zhang N, Jiang J, Tang S, Sun G (2020) Predictive value of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in non-small cell lung cancer patients treated with immune checkpoint inhibitors: a meta-analysis. Int Immunopharmacol 85:106677PubMedCrossRef

18.

Mirili C, Guney IB, Paydas S, Seydaoglu G, Kapukaya TK, Ogul A, Gokcay S, Buyuksimsek M, Yetisir AE, Karaalioglu B et al (2019) Prognostic significance of neutrophil/lymphocyte ratio (NLR) and correlation with PET-CT metabolic parameters in small cell lung cancer (SCLC). Int J Clin Oncol 24(2):168–178PubMedCrossRef

19.

Sebastian NT, Raj R, Prasad R, Barney C, Brownstein J, Grecula J, Haglund K, Xu-Welliver M, Williams TM, Bazan JG (2020) Association of Pre- and Posttreatment Neutrophil-Lymphocyte Ratio With Recurrence and Mortality in Locally Advanced Non-Small Cell Lung Cancer. Front Oncol 10:598873PubMedPubMedCentralCrossRef

20.

Luo H, Ge H, Cui Y, Zhang J, Fan R, Zheng A, Zheng X, Sun Y (2018) Systemic Inflammation Biomarkers Predict Survival in Patients of Early Stage Non-Small Cell Lung Cancer Treated With Stereotactic Ablative Radiotherapy - A Single Center Experience. J Cancer 9(1):182–188PubMedPubMedCentralCrossRef

21.

Yang R, Chang Q, Meng X, Gao N, Wang W (2018) Prognostic value of Systemic immune-inflammation index in cancer: A meta-analysis. J Cancer 9(18):3295–3302PubMedPubMedCentralCrossRef

22.

Li X, Hu P, Liu J, Zhang J, Liu Q (2020) Systemic immune-inflammation index predicted overall survival and radiosensitivity in advanced non-small-cell lung cancer. Future Oncol 16(5):103–115PubMedCrossRef

23.

Chen L, Kong X, Wang Z, Wang X, Fang Y, Wang J (2020) Pretreatment Systemic Inflammation Response Index in Patients with Breast Cancer Treated with Neoadjuvant Chemotherapy as a Useful Prognostic Indicator. Cancer Manag Res 12:1543–1567PubMedPubMedCentralCrossRef

24.

Valero C, Pardo L, Sansa A, Garcia Lorenzo J, Lopez M, Quer M, Leon X (2020) Prognostic capacity of Systemic Inflammation Response Index (SIRI) in patients with head and neck squamous cell carcinoma. Head Neck 42(2):336–343PubMedCrossRef

25.

Zhang Y, Liu F, Wang Y (2020) Evidence of the Prognostic Value of Pretreatment Systemic Inflammation Response Index in Cancer Patients: A Pooled Analysis of 19 Cohort Studies. Dis Markers 2020:8854267PubMedPubMedCentral

26.

Jin S, Cao S, Xu S, Wang C, Meng Q, Yu Y (2018) Clinical impact of pretreatment prognostic nutritional index (PNI) in small cell lung cancer patients treated with platinum-based chemotherapy. Clin Respir J 12(9):2433–2440PubMedCrossRef

27.

Jiang AM, Zhao R, Liu N, Ma YY, Ren MD, Tian T, Yao Y (2020) The prognostic value of pretreatment prognostic nutritional index in patients with small cell lung cancer and it’s influencing factors: a meta-analysis of observational studies. J Thorac Dis 12(10):5718–5728PubMedPubMedCentralCrossRef

28.

Mezquita L, Auclin E, Ferrara R, Charrier M, Remon J, Planchard D, Ponce S, Ares LP, Leroy L, Audigier-Valette C et al (2018) Association of the lung immune prognostic index with immune checkpoint inhibitor outcomes in patients with advanced non-small cell lung cancer. JAMA Oncol 4(3):351–357PubMedPubMedCentralCrossRef

29.

Aldea M, Benitez JC, Mezquita L (2020) The lung immune prognostic index (LIPI) stratifies prognostic groups in advanced non-small cell lung cancer (NSCLC) patients. Transl Lung Cancer Res 9(4):967–970PubMedPubMedCentralCrossRef

30.

Wang W, Huang Z, Yu Z, Zhuang W, Zheng W, Cai Z, Shi L, Yu X, Lou G, Hong W et al (2020) Prognostic value of the lung immune prognostic index may differ in patients treated with immune checkpoint inhibitor monotherapy or combined with chemotherapy for non-small cell lung cancer. Front Oncol 10:572853PubMedPubMedCentralCrossRef

31.

Daniel D, Kuchava V, Bondarenko I, Ivashchuk O, Reddy S, Jaal J, Kudaba I, Hart L, Matitashvili A, Pritchett Y et al (2020) Trilaciclib prior to chemotherapy and atezolizumab in patients with newly diagnosed extensive-stage small cell lung cancer: a multicentre randomised double-blind placebo-controlled phase II trial. Int J Cancer. https://doi.org/10.1002/ijc.33453CrossRefPubMed

32.

Gao J, Wang Y, Li F, Zhu Z, Han B, Wang R, Xie R, Xue Y (2019) Prognostic nutritional index and neutrophil-to-lymphocyte ratio are respectively associated with prognosis of gastric cancer with liver metatasis undergoing and without hepatectomy. Biomed Res Int 2019:4213623PubMedPubMedCentral

33.

Galvano A, Peri M, Guarini AA, Castiglia M, Grassadonia A, De Tursi M, Irtelli L, Rizzo S, Bertani A, Gristina V et al (2020) Analysis of systemic inflammatory biomarkers in neuroendocrine carcinomas of the lung: prognostic and predictive significance of NLR, LDH, ALI, and LIPI score. Ther Adv Med Oncol 12:1758835920942378PubMedPubMedCentralCrossRef

34.

Ott PA, Elez E, Hiret S, Kim DW, Morosky A, Saraf S, Piperdi B, Mehnert JM (2017) Pembrolizumab in patients with extensive-stage small-cell lung cancer: results from the phase Ib KEYNOTE-028 Study. J Clin Oncol Off J Am Soc Clin Oncol 35(34):3823–3829CrossRef

35.

Mantovani A, Allavena P, Sica A, Balkwill F (2008) Cancer-related inflammation. Nature 454(7203):436–444PubMedCrossRef

36.

Hu H, Yao X, Xie X, Wu X, Zheng C, Xia W, Ma S (2017) Prognostic value of preoperative NLR, dNLR, PLR and CRP in surgical renal cell carcinoma patients. World J Urol 35(2):261–270PubMedCrossRef

37.

Wang K, Diao F, Ye Z, Zhang X, Zhai E, Ren H, Li T, Wu H, He Y, Cai S et al (2017) Prognostic value of systemic immune-inflammation index in patients with gastric cancer. Chin J Cancer 36(1):75PubMedPubMedCentralCrossRef

38.

Dolan RD, Laird BJA, Horgan PG, McMillan DC (2018) The prognostic value of the systemic inflammatory response in randomised clinical trials in cancer: a systematic review. Crit Rev Oncol Hematol 132:130–137PubMedCrossRef

39.

Duan J, Pan L, Yang M (2018) Preoperative elevated neutrophil-to-lymphocyte ratio (NLR) and derived NLR are associated with poor prognosis in patients with breast cancer: a meta-analysis. Medicine 97(49):e13340PubMedPubMedCentralCrossRef

40.

Lee GW, Park SW, Go SI, Kim HG, Kim MK, Min CK, Kwak JY, Bae SB, Yoon SS, Lee JJ et al (2018) The derived neutrophil-to-lymphocyte ratio is an independent prognostic factor in transplantation ineligible patients with multiple myeloma. Acta Haematol 140(3):146–156PubMedCrossRef

41.

Liu JX, Li A, Zhou LY, Liu XF, Wei ZH, Wang XZ, Ying HQ (2018) Significance of combined preoperative serum Alb and dNLR for diagnosis of pancreatic cancer. Future Oncol 14(3):229–239PubMedCrossRef

42.

Liu XF, Zhou LY, Wei ZH, Liu JX, Li A, Wang XZ, Ying HQ (2018) The diagnostic role of circulating inflammation-based biomarker in gallbladder carcinoma. Biomark Med 12(10):1095–1103PubMedCrossRef

43.

Petrova MP, Eneva MI, Arabadjiev JI, Conev NV, Dimitrova EG, Koynov KD, Karanikolova TS, Valev SS, Gencheva RB, Zhbantov GA et al (2020) Neutrophil to lymphocyte ratio as a potential predictive marker for treatment with pembrolizumab as a second line treatment in patients with non-small cell lung cancer. Biosci Trends 14(1):48–55PubMedCrossRef

44.

Matsubara T, Takamori S, Haratake N, Toyozawa R, Miura N, Shimokawa M, Yamaguchi M, Seto T, Takenoyama M (2020) The impact of immune-inflammation-nutritional parameters on the prognosis of non-small cell lung cancer patients treated with atezolizumab. J Thorac Dis 12(4):1520–1528PubMedPubMedCentralCrossRef

45.

Ohba T, Takamori S, Toyozawa R, Nosaki K, Umeyama Y, Haratake N, Miura N, Yamaguchi M, Taguchi K, Seto T et al (2019) Prognostic impact of the controlling nutritional status score in patients with non-small cell lung cancer treated with pembrolizumab. J Thorac Dis 11(9):3757–3768PubMedPubMedCentralCrossRef

46.

Failing JJ, Yan Y, Porrata LF, Markovic SN (2017) Lymphocyte-to-monocyte ratio is associated with survival in pembrolizumab-treated metastatic melanoma patients. Melanoma Res 27(6):596–600PubMedCrossRef

47.

Kazandjian D, Gong Y, Keegan P, Pazdur R, Blumenthal GM (2019) Prognostic value of the lung immune prognostic index for patients treated for metastatic non-small cell lung cancer. JAMA Oncol. https://doi.org/10.1001/jamaoncol.2019.1747CrossRefPubMedPubMedCentral

48.

Bilen MA, Martini DJ, Liu Y, Lewis C, Collins HH, Shabto JM, Akce M, Kissick HT, Carthon BC, Shaib WL et al (2019) The prognostic and predictive impact of inflammatory biomarkers in patients who have advanced-stage cancer treated with immunotherapy. Cancer 125(1):127–134PubMedCrossRef

49.

Xu H, He A, Liu A, Tong W, Cao D (2019) Evaluation of the prognostic role of platelet-lymphocyte ratio in cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis. Int Immunopharmacol 77:105957PubMedCrossRef

Titel: Assessment of systematic inflammatory and nutritional indexes in extensive-stage small-cell lung cancer treated with first-line chemotherapy and atezolizumab
verfasst von: Wei-Xiang Qi
Yi Xiang
Shengguang Zhao
Jiayi Chen
Publikationsdatum: 01.04.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 11/2021
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-021-02926-3

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Assessment of systematic inflammatory and nutritional indexes in extensive-stage small-cell lung cancer treated with first-line chemotherapy and atezolizumab

Abstract

Background

Materials and methods

Results

Conclusion

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