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CardioVascular and Interventional Radiology
Erschienen in: CardioVascular and Interventional Radiology 5/2018

17.01.2018 | Clinical Investigation

Prognostic Factors in Overall Survival of Patients with Unresectable Intrahepatic Cholangiocarcinoma Treated by Means of Yttrium-90 Radioembolization: Results in Therapy-Naïve Patients

verfasst von: P. Reimer, M. K. Virarkar, M. Binnenhei, M. Justinger, M. R. Schön, K. Tatsch

Erschienen in: CardioVascular and Interventional Radiology | Ausgabe 5/2018

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Abstract

Introduction

To investigate prognostic factors in unresectable intrahepatic cholangiocarcinoma (ICC) therapy-naïve patients after yttrium-90 (Y-90) radioembolization (RE) therapy.

Materials and Methods

Between 2005 and 2016, 21 patients with ICC were treated with Y-90 RE only and their survival data were analyzed. Patients were stratified and response was assessed by the Response Evaluation Criteria in Solid Tumors (RECIST) criteria.

Result

The overall median survival was 15 months. Survival was significantly (p = 0.009) prolonged in patients with tumor burden of ≤ 25% (n = 8, OS 37.5 months) versus those with a tumor burden of 25–50% (n = 13, OS 15 months). The other variables: tumor morphology (infiltrative vs. peripheral), tumor distribution (solitary vs. multifocal), lobes involved (unilobar vs. bilobar), FDG PET status (FDG avid vs. non-avid), RE treatment sessions (1 session vs. 2 sessions), metastases (metastasis vs. no metastasis) and RECIST criteria, had no significant impact on survival.

Conclusion

Tumor burden represents a key prognostic factor of survival in therapy-naïve patients with unresectable ICC treated with Y-90 RE therapy only.
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Metadaten
Titel
Prognostic Factors in Overall Survival of Patients with Unresectable Intrahepatic Cholangiocarcinoma Treated by Means of Yttrium-90 Radioembolization: Results in Therapy-Naïve Patients
verfasst von
P. Reimer
M. K. Virarkar
M. Binnenhei
M. Justinger
M. R. Schön
K. Tatsch
Publikationsdatum
17.01.2018
Verlag
Springer US
Erschienen in
CardioVascular and Interventional Radiology / Ausgabe 5/2018
Print ISSN: 0174-1551
Elektronische ISSN: 1432-086X
DOI
https://doi.org/10.1007/s00270-017-1871-2

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