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Erschienen in: Cancer Chemotherapy and Pharmacology 1/2006

01.01.2006 | Short Communication

Treatment of anthracycline extravasation in mice with dexrazoxane with or without DMSO and hydrocortisone

verfasst von: Seppo W. Langer, Annemette V. Thougaard, Maxwell Sehested, Peter Buhl Jensen

Erschienen in: Cancer Chemotherapy and Pharmacology | Ausgabe 1/2006

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Abstract

Dexrazoxane has been reported to be protective against anthracycline induced subcutaneous ulceration in mice. It is currently under clinical investigation as an acute antidote in accidental anthracycline extravasation, for which indication topical dimethylsulfoxide (DMSO) and intralesional hydrocortisone are used empirically. We studied the effect in 72 mice of monotherapy with and combined therapy of intraperitoneal dexrazoxane, topical DMSO, and intralesional hydrocortisone as acute antidotes against ulceration after subcutaneous daunorubicin. Dexrazoxane completely prevented wounds from occurring, while neither DMSO nor hydrocortisone had any preventive effect. The addition of topical DMSO actually reduced the efficacy of dexrazoxane. In conclusion, the present study does not support the concomitant use of topical DMSO + systemic dexrazoxane or intralesional hydrocortisone + systemic dexrazoxane. Monotherapy with systemic dexrazoxane seems preferable and is highly efficacious in preventing ulceration.
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Metadaten
Titel
Treatment of anthracycline extravasation in mice with dexrazoxane with or without DMSO and hydrocortisone
verfasst von
Seppo W. Langer
Annemette V. Thougaard
Maxwell Sehested
Peter Buhl Jensen
Publikationsdatum
01.01.2006
Verlag
Springer-Verlag
Erschienen in
Cancer Chemotherapy and Pharmacology / Ausgabe 1/2006
Print ISSN: 0344-5704
Elektronische ISSN: 1432-0843
DOI
https://doi.org/10.1007/s00280-005-0022-7

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