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Seminars in Immunopathology

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01.03.2005 | Original Article

Human innate B cells: a link between host defense and autoimmunity?

verfasst von: Eric C. B. Milner, Jennifer Anolik, Amedeo Cappione, Iñaki Sanz

Erschienen in: Seminars in Immunopathology | Ausgabe 4/2005

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Abstract

B cells play a variety of immunoregulatory roles through their antigen-presentation ability and through cytokine and chemokine production. Innate immune activation of B cells may play a beneficial role through the generation of natural cross-reactive antibodies, by maintaining B cell memory and by exercising immunomodulatory functions that may provide protection against autoimmunity. In this article, we review human B cell populations and their functional properties, with a particular focus on a population of inherently autoreactive B cells, which seem to play an important physiological role in innate immunity, but which, if selected into adaptive immune responses, appear to become pathogenic agents in systemic lupus erythematosus.

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Titel: Human innate B cells: a link between host defense and autoimmunity?
verfasst von: Eric C. B. Milner
Jennifer Anolik
Amedeo Cappione
Iñaki Sanz
Publikationsdatum: 01.03.2005
Verlag: Springer-Verlag
Erschienen in: Seminars in Immunopathology / Ausgabe 4/2005
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-004-0188-9

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