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01.10.2015 | Hepatobiliary-Pancreas

Comparison between modified Dixon MRI techniques, MR spectroscopic relaxometry, and different histologic quantification methods in the assessment of hepatic steatosis

verfasst von: Guido M. Kukuk, Kanishka Hittatiya, Alois M. Sprinkart, Holger Eggers, Jürgen Gieseke, Wolfgang Block, Philipp Moeller, Winfried A. Willinek, Ulrich Spengler, Jonel Trebicka, Hans-Peter Fischer, Hans H. Schild, Frank Träber

Erschienen in: European Radiology | Ausgabe 10/2015

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Abstract

Objectives

To compare systematically quantitative MRI, MR spectroscopy (MRS), and different histological methods for liver fat quantification in order to identify possible incongruities.

Methods

Fifty-nine consecutive patients with liver disorders were examined on a 3 T MRI system. Quantitative MRI was performed using a dual- and a six-echo variant of the modified Dixon (mDixon) sequence, calculating proton density fat fraction (PDFF) maps, in addition to single-voxel MRS. Histological fat quantification included estimation of the percentage of hepatocytes containing fat vesicles as well as semi-automatic quantification (qHisto) using tissue quantification software.

Results

In 33 of 59 patients, the hepatic fat fraction was >5 % as determined by MRS (maximum 45 %, mean 17 %). Dual-echo mDixon yielded systematically lower PDFF values than six-echo mDixon (mean difference 1.0 %; P < 0.001). Six-echo mDixon correlated excellently with MRS, qHisto, and the estimated percentage of hepatocytes containing fat vesicles (R = 0.984, 0.967, 0.941, respectively, all P < 0.001). Mean values obtained by the estimated percentage of hepatocytes containing fat were higher by a factor of 2.5 in comparison to qHisto. Six-echo mDixon and MRS showed the best agreement with values obtained by qHisto.

Conclusions

Six-echo mDixon, MRS, and qHisto provide the most robust and congruent results and are therefore most appropriate for reliable quantification of liver fat.

Key Points

• Six-echo mDixon correlates excellently with MRS, qHisto, and the estimated percentage of fat-containing hepatocytes.

• Six-echo mDixon, MRS, and qHisto provide the most robust and congruent results.

• Dual-echo mDixon yields systematically lower PDFF values than six-echo mDixon.

• The percentage of fat-containing hepatocytes is 2.5-fold higher than fat fraction determined by qHisto.

• Performance characteristics and systematic differences of the various methods should be considered.

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Titel: Comparison between modified Dixon MRI techniques, MR spectroscopic relaxometry, and different histologic quantification methods in the assessment of hepatic steatosis
verfasst von: Guido M. Kukuk
Kanishka Hittatiya
Alois M. Sprinkart
Holger Eggers
Jürgen Gieseke
Wolfgang Block
Philipp Moeller
Winfried A. Willinek
Ulrich Spengler
Jonel Trebicka
Hans-Peter Fischer
Hans H. Schild
Frank Träber
Publikationsdatum: 01.10.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 10/2015
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-015-3703-6

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Comparison between modified Dixon MRI techniques, MR spectroscopic relaxometry, and different histologic quantification methods in the assessment of hepatic steatosis