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Erschienen in: World Journal of Urology 2/2017

04.06.2016 | Original Article

Prospective assessment of perioperative course in 2648 patients after surgical treatment of benign prostatic obstruction

verfasst von: Thorsten Bach, Felix Wölbling, Andreas J. Gross, C. Netsch, S. Tauber, Tobias Pottek, Christian Wülfing, Claus Brunken

Erschienen in: World Journal of Urology | Ausgabe 2/2017

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Abstract

Purpose

TUR-prostate (TUR-P) is considered the reference method for surgical treatment of benign prostatic obstruction (BPO); Greenlight laser photoselective vaporization (PVP) and thulium laser vapoenucleation (ThuVEP) have also been established as treatments of BPO. Objective of this prospective observation was to compare a large numbers of patients treated in everyday routine.

Methods

This prospective multicentre data collection assesses morbidity and perioperative course of consecutive men treated with BPO-related transurethral surgery between 2011 and 2014 in a German metropolis area with TUR-P, PVP or ThuVEP.

Results

Two thousand six hundred and forty-eight patients have been treated in the time period. All treatment options achieved immediate improvement of voiding parameters. Multivariate analyses proved shorter hospital stay after laser treatments as compared to resection (p < 0.001). In terms of hospital stay, the advantage of ThuVEP compared to TUR-P increased with prostate volume (p < 0.001). Patients with ongoing anticoagulation or bridging had prolonged hospital stay (p < 0.001). Overall adverse events were least frequent in PVP (p 0.016), as were Clavien 3b events (p < 0.001).

Conclusions

Surgical treatment of BPO is effective and safe independent of the surgical procedure. Volume reduction is most effective in ThuVEP; PVP has the lowest rate of severe complications. Laser treatment is associated with shorter hospital stay. Surgery under ongoing anticoagulation prolonged the post-operative hospital stay.
Literatur
1.
Zurück zum Zitat Gravas S, Bach T; Bachmann A, Drake M, Gacci M, Gratzke C, Madersbacher S, Mamoulakis C, Tikkinen KAO, Karavitakis M, Malde S, Sakkalis V, Umbach R (2016) EAU guidelines in treatment of non-neurogenic male LUTS. www.uroweb.org. 20th March 2016 Gravas S, Bach T; Bachmann A, Drake M, Gacci M, Gratzke C, Madersbacher S, Mamoulakis C, Tikkinen KAO, Karavitakis M, Malde S, Sakkalis V, Umbach R (2016) EAU guidelines in treatment of non-neurogenic male LUTS. www.​uroweb.​org. 20th March 2016
2.
Zurück zum Zitat Thomas JA, Tubaro A, Barber N, Dáncona F, Muir G, Witzsch U, Grimm MO, Benejam J, Stolzenburg JU, Riddick A, Pahernik S, Roelink H, Amaye F, Saussine C, Bruyere F, Loidl W, Larner T, Gogoi NK, Hindley R, Muschter R, Thorpe A, Shroti N, Grahim S, Hamann M, Miller K, Schostak M, Capitán C, Knispel H, Bachmann A (2016) A multicenter randomized noninferiority trial comparing GreenLight-XPS laser vaporization of the prostate and transurethral resection of the prostate for the treatment of benign prostatic obstruction: two-yr. outcomes of the GOLIATH study. Eur Urol 69:94–102CrossRefPubMed Thomas JA, Tubaro A, Barber N, Dáncona F, Muir G, Witzsch U, Grimm MO, Benejam J, Stolzenburg JU, Riddick A, Pahernik S, Roelink H, Amaye F, Saussine C, Bruyere F, Loidl W, Larner T, Gogoi NK, Hindley R, Muschter R, Thorpe A, Shroti N, Grahim S, Hamann M, Miller K, Schostak M, Capitán C, Knispel H, Bachmann A (2016) A multicenter randomized noninferiority trial comparing GreenLight-XPS laser vaporization of the prostate and transurethral resection of the prostate for the treatment of benign prostatic obstruction: two-yr. outcomes of the GOLIATH study. Eur Urol 69:94–102CrossRefPubMed
3.
Zurück zum Zitat Netsch C, Engbert A, Bach T, Gross AJ (2014) Long-term outcome following Thulium VapoEnucleation of the prostate. World J Urol 32:1551–1558CrossRefPubMed Netsch C, Engbert A, Bach T, Gross AJ (2014) Long-term outcome following Thulium VapoEnucleation of the prostate. World J Urol 32:1551–1558CrossRefPubMed
4.
Zurück zum Zitat Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240:205–213CrossRefPubMedPubMedCentral Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240:205–213CrossRefPubMedPubMedCentral
5.
Zurück zum Zitat Mitropoulos D, Artibani W, Graefen M, Remzi M, Roupret M, Truss M (2012) Reporting and grading of complications after urologic surgical procedures: an ad hoc EAU Guidelines panel assessment and recommendations. Eur Urol 61:341–349CrossRefPubMed Mitropoulos D, Artibani W, Graefen M, Remzi M, Roupret M, Truss M (2012) Reporting and grading of complications after urologic surgical procedures: an ad hoc EAU Guidelines panel assessment and recommendations. Eur Urol 61:341–349CrossRefPubMed
6.
Zurück zum Zitat Bach T, Netsch C, Pohlmann L, Herrman TR, Gross AJ (2010) Thulium:YAG laser enucleation in large volume prostates. J Urol 186:2323–2327CrossRef Bach T, Netsch C, Pohlmann L, Herrman TR, Gross AJ (2010) Thulium:YAG laser enucleation in large volume prostates. J Urol 186:2323–2327CrossRef
7.
Zurück zum Zitat Bachmann A, Tubaro A, Barber N, Dácona F, Muir G, Witzsch U, Grimmm MO, Benejam J, Stolzenburg JU, Riddick A, Pahernik S, Roelink H, Amaye F, Saussine C, Bruyére F, Loidl W, Larner T, Gogoi NK, Hindley R, Muschter R, Thorpe A, Shroti N, Graham S, Hamann M, Miller K, Schostak M, Capitán C, Knispel H, Thomas AJ, The GOLIATH study (2014) 180-W XPS Greenlight laser vaporisation versus transurethral resection of the prostate for the treatment of benign prostatic obstruction: 6-month safety and efficacy results of e European multicentre rendomised trail. Eur Urol 65:931–942CrossRefPubMed Bachmann A, Tubaro A, Barber N, Dácona F, Muir G, Witzsch U, Grimmm MO, Benejam J, Stolzenburg JU, Riddick A, Pahernik S, Roelink H, Amaye F, Saussine C, Bruyére F, Loidl W, Larner T, Gogoi NK, Hindley R, Muschter R, Thorpe A, Shroti N, Graham S, Hamann M, Miller K, Schostak M, Capitán C, Knispel H, Thomas AJ, The GOLIATH study (2014) 180-W XPS Greenlight laser vaporisation versus transurethral resection of the prostate for the treatment of benign prostatic obstruction: 6-month safety and efficacy results of e European multicentre rendomised trail. Eur Urol 65:931–942CrossRefPubMed
8.
Zurück zum Zitat Cornu JN, Ahyai SA, Bachmann A, de la Rosette J, Gilling P, Gratzke C, McVary K, Novara G, Woo H, Madersbacher S (2015) A systematic review and meta-analysis of functional outcomes and complications following transurethral procedures for lower urinary tract symptoms resulting from benign prostatic obstruction: an update. Eur Urol 67:1066–1096CrossRefPubMed Cornu JN, Ahyai SA, Bachmann A, de la Rosette J, Gilling P, Gratzke C, McVary K, Novara G, Woo H, Madersbacher S (2015) A systematic review and meta-analysis of functional outcomes and complications following transurethral procedures for lower urinary tract symptoms resulting from benign prostatic obstruction: an update. Eur Urol 67:1066–1096CrossRefPubMed
9.
Zurück zum Zitat Yang Z, Wang X, Liu T (2013) Thulium laser enucleation versus plasmakinetic resection of the prostate: a randomized prospective trial with 18-month follow-up. Urology 81:396–401CrossRefPubMed Yang Z, Wang X, Liu T (2013) Thulium laser enucleation versus plasmakinetic resection of the prostate: a randomized prospective trial with 18-month follow-up. Urology 81:396–401CrossRefPubMed
10.
Zurück zum Zitat Ahyai SA, Gilling P, Kaplan SA, Kuntz RM, Madersbacher S, Montorsi F, Speakman MJ, Stief CG (2010) Meta-analysis of functional outcomes and complications following transurethral procedures for lower urinary tract symptoms resulting from benign prostatic enlargement. Eur Urol 58:384–397CrossRefPubMed Ahyai SA, Gilling P, Kaplan SA, Kuntz RM, Madersbacher S, Montorsi F, Speakman MJ, Stief CG (2010) Meta-analysis of functional outcomes and complications following transurethral procedures for lower urinary tract symptoms resulting from benign prostatic enlargement. Eur Urol 58:384–397CrossRefPubMed
11.
Zurück zum Zitat Netsch C, Tiburtius C, Bach T, Knipper S, Gross AJ (2014) Association of Prostate size and perioperative morbidity in thulium:YAG vapoenucleation of the prostate. Urol Int 93:22–28PubMed Netsch C, Tiburtius C, Bach T, Knipper S, Gross AJ (2014) Association of Prostate size and perioperative morbidity in thulium:YAG vapoenucleation of the prostate. Urol Int 93:22–28PubMed
12.
Zurück zum Zitat Gross AJ, Netsch C, Knipper S, Hölzel J, Bach T (2013) Complications and early postoperative outcome in 1080 patients after thulium vapoenucleation of the prostate: results at a single institution. Eur Urol 63:859–867CrossRefPubMed Gross AJ, Netsch C, Knipper S, Hölzel J, Bach T (2013) Complications and early postoperative outcome in 1080 patients after thulium vapoenucleation of the prostate: results at a single institution. Eur Urol 63:859–867CrossRefPubMed
13.
Zurück zum Zitat Reich O, Gratzke C, Bachmann A, Seitz M, Schlenker B, Hermanek P, Lack N, Stief CG (2008) Morbidity, mortality and early outcome of transurethral resection of the prostate: a prospective multicenter evaluation of 10654 patients. J Urol 180:246–249CrossRefPubMed Reich O, Gratzke C, Bachmann A, Seitz M, Schlenker B, Hermanek P, Lack N, Stief CG (2008) Morbidity, mortality and early outcome of transurethral resection of the prostate: a prospective multicenter evaluation of 10654 patients. J Urol 180:246–249CrossRefPubMed
14.
Zurück zum Zitat Varkarakis I, Kyriakakis Z, Delis A, Protogerou V, Deliveliotis C (2004) Long-term results of open transvesical prostatectomy from a contemporary series of patients. Urology 64:306–310CrossRefPubMed Varkarakis I, Kyriakakis Z, Delis A, Protogerou V, Deliveliotis C (2004) Long-term results of open transvesical prostatectomy from a contemporary series of patients. Urology 64:306–310CrossRefPubMed
15.
Zurück zum Zitat Adam C, Hofstetter A, Deubner J et al (2004) Retropubic transvesical prostatectomy for significant prostatic enlargement must remain a standard part of urology training. Scand J Urol Nephrol 38:472–476CrossRefPubMed Adam C, Hofstetter A, Deubner J et al (2004) Retropubic transvesical prostatectomy for significant prostatic enlargement must remain a standard part of urology training. Scand J Urol Nephrol 38:472–476CrossRefPubMed
16.
Zurück zum Zitat Serrat V, Morgia G, Fondacaro L et al., members of the Sicilian Calabrian Society of Urology (2002) Open prostatectomy for benign prostatic enlargement in southern Europe in the late 1990s: a contemporary series of 1800 interventions. Urology 60:623–627 Serrat V, Morgia G, Fondacaro L et al., members of the Sicilian Calabrian Society of Urology (2002) Open prostatectomy for benign prostatic enlargement in southern Europe in the late 1990s: a contemporary series of 1800 interventions. Urology 60:623–627
Metadaten
Titel
Prospective assessment of perioperative course in 2648 patients after surgical treatment of benign prostatic obstruction
verfasst von
Thorsten Bach
Felix Wölbling
Andreas J. Gross
C. Netsch
S. Tauber
Tobias Pottek
Christian Wülfing
Claus Brunken
Publikationsdatum
04.06.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
World Journal of Urology / Ausgabe 2/2017
Print ISSN: 0724-4983
Elektronische ISSN: 1433-8726
DOI
https://doi.org/10.1007/s00345-016-1866-7

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