Erschienen in:
01.05.2018 | Editorial
25 years of remote ischemic conditioning: from laboratory curiosity to clinical outcome
verfasst von:
Gerd Heusch
Erschienen in:
Basic Research in Cardiology
|
Ausgabe 3/2018
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Excerpt
It is now 25 years ago that Przyklenk et al. first reported the phenomenon of remote ischemic preconditioning [
20]. They were intrigued by infarct size reduction through ischemic preconditioning [
19] and had hypothesized from a mathematical model that a preconditioning cycle of ischemia/reperfusion might initiate a protective signal/molecule which could diffuse over a certain distance [
25]. Indeed, in anesthetized dogs, they demonstrated that four cycles of 5 min left circumflex coronary artery occlusion/5 min reperfusion reduced the infarct size resulting from 60 min left anterior descending coronary artery occlusion/reperfusion [
20]. Initially, such ischemic conditioning interaction between two adjacent coronary vascular perfusion territories seemed like a laboratory curiosity. However, then the paradigm of “cardioprotection at a distance” by ischemic conditioning was quickly extended to other organs and tissues and to longer distances from the heart. …