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Archives of Orthopaedic and Trauma Surgery

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01.12.2011 | Orthopaedic Outcome Assessment

Intra-articular injection of hyaluronic acid (MW 1,500–2,000 kDa; HyalOne^®) in symptomatic osteoarthritis of the hip: a prospective cohort study

verfasst von: Migliore Alberto, Massafra Umberto, Bizzi Emanuele, Laganà Bruno, Germano Valentina, Piscitelli Prisco, Granata Mauro, Tormenta Sandro

Erschienen in: Archives of Orthopaedic and Trauma Surgery | Ausgabe 12/2011

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Abstract

Introduction

Clinical trials have demonstrated the safety and efficacy of hyaluronic acid-based products for the treatment of hip osteoarthritis, but data from observational studies of normal medical practice are scarce. This study investigated the long-term efficacy and tolerability of ultrasound-guided intra-articular sodium hyaluronate (MW 1,500–2,000 kDa; Hyalone^®) injections in daily clinical practice.

Methods

In this observational, cohort study of patients with hip osteoarthritis, Hyalone^® was administered under the ultrasound guidance, every 6 months, with the possibility of an additional injection at the intervening 3-month intervals on clinical request. Efficacy measurements included the Lequesne algofunctional index, self-reported pain via the visual analogue scale (VAS), the concomitant use of non-steroidal anti-inflammatory drugs (NSAIDs) and safety. The patients were followed up for 18 months after the first intra-articular injection.

Results

Data from 120 patients were collected. During the study, a statistically significant reduction in algofunctional indexes was demonstrated at 3 months after study product injection, while at 12 months 80% of the patients achieved a decrease of at least 30% in symptoms. These results were maintained over time through cyclical and personalized repetition of ultrasound guided injections, at least one injection every 6 months.

Conclusions

The study treatment reduced pain and improved mobility in osteoarthritis of the hip. These results in daily clinical practice demonstrate a beneficial effect and the safety of the study product and suggest adding intra-articular injections of HyalOne^® to the armamentarium of conservative management of symptomatic hip osteoarthritis.

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Titel: Intra-articular injection of hyaluronic acid (MW 1,500–2,000 kDa; HyalOne®) in symptomatic osteoarthritis of the hip: a prospective cohort study
verfasst von: Migliore Alberto
Massafra Umberto
Bizzi Emanuele
Laganà Bruno
Germano Valentina
Piscitelli Prisco
Granata Mauro
Tormenta Sandro
Publikationsdatum: 01.12.2011
Verlag: Springer-Verlag
Erschienen in: Archives of Orthopaedic and Trauma Surgery / Ausgabe 12/2011
Print ISSN: 0936-8051
Elektronische ISSN: 1434-3916
DOI: https://doi.org/10.1007/s00402-011-1353-y

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Intra-articular injection of hyaluronic acid (MW 1,500–2,000 kDa; HyalOne^®) in symptomatic osteoarthritis of the hip: a prospective cohort study