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01.01.2004 | Review

Ageing of the retinal pigment epithelium: implications for transplantation

verfasst von: Mike Boulton, Malgorzata Różanowska, Tim Wess

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 1/2004

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Abstract

This review will discuss some of the implications for using cells from aged donors for retinal pigment epithelium (RPE) transplantation. It will consider age-related changes in the structure and function of RPE cells and the accumulation of potentially damaging photoreactive constituents. The review will focus on the role of the ocular pigments lipofuscin and melanin in respect to age-related changes in composition, photoreactivity and potential role in retinal ageing and age-related macular degeneration. The article concludes by considering the suitability of senescent RPE cells for transplantation and whether such cells can be rejuvenated.

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Titel: Ageing of the retinal pigment epithelium: implications for transplantation
verfasst von: Mike Boulton
Malgorzata Różanowska
Tim Wess
Publikationsdatum: 01.01.2004
Verlag: Springer-Verlag
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 1/2004
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-003-0812-8

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Ageing of the retinal pigment epithelium: implications for transplantation

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