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International Archives of Occupational and Environmental Health

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01.04.2007 | Original Article

Exposure–response relationship between endotoxin exposure and lung function impairment in cotton textile workers

verfasst von: Marcus Oldenburg, Ute Latza, Xaver Baur

Erschienen in: International Archives of Occupational and Environmental Health | Ausgabe 5/2007

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Abstract

Objectives

Preventive workplace regulations are so far not based on an ubiquitously accepted threshold for airborne endotoxin in the bioaerosol.

Methods

In a cross-sectional study, 150 employees of a cotton spinning mill underwent lung function testing. Furthermore, in a random subset of 75 textile workers cross-shift lung function test and methacholine challenges were performed. Airborne current endotoxin exposure was classified as “low”, “medium”, and “high” (≤100, >100–≤450, and >450 Endotoxin Units (EU)/m³, respectively) based on endotoxin activity.

Results

The exposure–response relationship between current endotoxin exposure and prevalence of an obstructive ventilation pattern was significant (test for linear trend: P = 0.019); the adjusted odds ratio for high endotoxin exposure was 11.22 (95% confidence interval 1.03–121.17). Within individuals, FEV₁/FVC% was significantly reduced after the shift (paired t test: P = 0.009) but not related to current endotoxin exposure. Twelve workers showed bronchial hyperresponsiveness (8.1% before and 12.2% after the work shift; Fisher’s exact test: P = 0.021).

Conclusion

The study among German cotton textile workers suggests an exposure-dependent effect of current endotoxin exposure on lung function impairment with significant effects above 450 EU/m³.

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Titel: Exposure–response relationship between endotoxin exposure and lung function impairment in cotton textile workers
verfasst von: Marcus Oldenburg
Ute Latza
Xaver Baur
Publikationsdatum: 01.04.2007
Verlag: Springer-Verlag
Erschienen in: International Archives of Occupational and Environmental Health / Ausgabe 5/2007
Print ISSN: 0340-0131
Elektronische ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-006-0145-0

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Exposure–response relationship between endotoxin exposure and lung function impairment in cotton textile workers

Abstract

Objectives

Methods

Results

Conclusion

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Objectives

Methods

Results

Conclusion

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