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European Journal of Applied Physiology

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08.07.2023 | Invited Review

Resistance exercise stress: theoretical mechanisms for growth hormone processing and release from the anterior pituitary somatotroph

verfasst von: Wesley C. Hymer, William J. Kraemer

Erschienen in: European Journal of Applied Physiology | Ausgabe 9/2023

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Abstract

Heavy resistance exercise (HRE) is the most effective method for inducing muscular hypertrophy and stimulating anabolic hormones, including growth hormone, into the blood. In this review, we explore possible mechanisms within the GH secretory pathway of the pituitary somatotroph, which are likely to modulate the flow of hormone synthesis and packaging as it is processed prior to exocytosis. Special emphasis is placed on the secretory granule and its possible role as a signaling hub. We also review data that summarize how HRE affects the quality and quantity of the secreted hormone. Finally, these pathway mechanisms are considered in the context of heterogeneity of the somatotroph population in the anterior pituitary.

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Titel: Resistance exercise stress: theoretical mechanisms for growth hormone processing and release from the anterior pituitary somatotroph
verfasst von: Wesley C. Hymer
William J. Kraemer
Publikationsdatum: 08.07.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Applied Physiology / Ausgabe 9/2023
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-023-05263-8

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