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Medical Microbiology and Immunology

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01.05.2004 | Original Investigation

Coxsackievirus replication and the cell cycle: a potential regulatory mechanism for viral persistence/latency

verfasst von: Ralph Feuer, Ignacio Mena, Robb R. Pagarigan, Daniel E. Hassett, J. Lindsay Whitton

Erschienen in: Medical Microbiology and Immunology | Ausgabe 2-3/2004

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Abstract

Coxsackieviruses (CV) are characterized by their ability to cause cytopathic effects in tissue culture and by their capacity to initiate acute disease by inducing apoptosis within targeted organs in vivo. These viruses are considered highly cytolytic, but can establish persistence/latency in susceptible cells, indicating that a regulatory mechanism may exist to shut off viral protein synthesis and replication under certain situations. The persistence of coxsackieviral RNA is of particular medical interest due to its association with chronic human diseases such as dilated cardiomyopathy and chronic inflammatory myopathy. Here, we discuss the potential mechanisms regulating coxsackievirus replication, and the ability of viral RNA to remain in an apparent latent state within quiescent cells.

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Titel: Coxsackievirus replication and the cell cycle: a potential regulatory mechanism for viral persistence/latency
verfasst von: Ralph Feuer
Ignacio Mena
Robb R. Pagarigan
Daniel E. Hassett
J. Lindsay Whitton
Publikationsdatum: 01.05.2004
Verlag: Springer-Verlag
Erschienen in: Medical Microbiology and Immunology / Ausgabe 2-3/2004
Print ISSN: 0300-8584
Elektronische ISSN: 1432-1831
DOI: https://doi.org/10.1007/s00430-003-0192-z

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