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01.11.2010 | Original Investigation

Epstein-Barr virus-associated pneumonia and bronchiolitis obliterans syndrome in a lung transplant recipient

verfasst von: Andi Krumbholz, Tim Sandhaus, Angela Göhlert, Albert Heim, Roland Zell, Renate Egerer, Martin Breuer, Eberhard Straube, Peter Wutzler, Andreas Sauerbrei

Erschienen in: Medical Microbiology and Immunology | Ausgabe 4/2010

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Abstract

We report the case of a 25-year-old lung and liver transplant recipient who developed respiratory failure. High levels of Epstein-Barr virus (EBV) genome copies were detectable in respiratory tract specimens, while the search for various other viral, bacterial or fungal pathogens remained empty. Post-transplant lymphoproliferative disease was excluded. Due to the rapid progression of respiratory insufficiency, a re-transplantation of the lung was performed. EBV-encoded small RNAs could be demonstrated by in situ hybridization within pneumocytes and lymphocytes of the explanted lung tissue. The clinical situation improved soon after re-transplantation, and the EBV load detected in the lower respiratory tract decreased significantly.

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Titel: Epstein-Barr virus-associated pneumonia and bronchiolitis obliterans syndrome in a lung transplant recipient
verfasst von: Andi Krumbholz
Tim Sandhaus
Angela Göhlert
Albert Heim
Roland Zell
Renate Egerer
Martin Breuer
Eberhard Straube
Peter Wutzler
Andreas Sauerbrei
Publikationsdatum: 01.11.2010
Verlag: Springer-Verlag
Erschienen in: Medical Microbiology and Immunology / Ausgabe 4/2010
Print ISSN: 0300-8584
Elektronische ISSN: 1432-1831
DOI: https://doi.org/10.1007/s00430-010-0165-y

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