Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Typ-2-Diabetes und Adipositas Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Die Highlights vom Kongress des American College of Cardiology 2024

Im April diskutierten die Herz-Kreislauf-Spezialisten aus der ganzen Welt auf dem  Kongress des American College of Cardiology (ACC) u.a. neue Therapieansätze bei akutem Myokardinfarkt, koronarer Herzerkrankung, kardiogenem Schock oder Aortenklappenstenose. In unserem Kongress-Dossier haben wir für Sie Berichte über die „Late-Breaking Trials“ und andere wichtige Studien zusammengestellt. 
Erweiterte Suche
Anmelden
nach oben
European Journal of Pediatrics
Erschienen in: European Journal of Pediatrics 5/2015

01.05.2015 | Original Article

Polymorphism rs2239185 in vitamin D receptor gene is associated with severe community-acquired pneumonia of children in Chinese Han population: a case-control study

verfasst von: Wei Li, Linying Guo, Hongri Li, Chunrong Sun, Xiaodai Cui, Guowei Song, Jianhua Wang, Qi Zhang

Erschienen in: European Journal of Pediatrics | Ausgabe 5/2015

Einloggen, um Zugang zu erhalten

Abstract

Vitamin D receptor (VDR) is a potential candidate gene for community-acquired pneumonia (CAP). Examining the susceptibility VDR gene for CAP is essential for early intervention, prevention of related complications, and improvement of outcome. A case-control study was performed to examine the association between rs2239185 of VDR gene and CAP among children in Chinese Han population. Polymerase chain reaction and direct sequencing were used to genotype rs2239185 in 91 CAP children and 94 healthy children. For rs2239185, individuals with TT genotype showed a significantly higher risk of CAP than those with CC plus CT genotypes (P = 0.008). The occurrence of T allele of rs2239185 was significantly more frequent in CAP children than those in normal controls (P = 0.045).We found through stratification analysis that CAP children with systemic inflammatory response syndrome (SIRS), leukocyte count (WBC) >10 × 109/L, C-reactive protein (CRP) >25 mg/L, procalcitonin (PCT) >2 ng/mL, and pediatric critical illness score <80 scores showed significantly higher frequency of TT genotype than those in normal controls (P = 0.0012, 0.0035, 0.0005, 0.0002, and 0.0021, respectively).
Conclusion: TT genotype of rs2239185 in VDR gene might be one of the potential genetic risk factors for CAP, and T allele of rs2239185 might be associated with the susceptibility to CAP and the severity of CAP.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Baig S, Moatter T (2010) Vitamin D is not just about healthy bones anymore. J Coll Physicians Surg Pak 20(6):355PubMed
2.
Ban Y, Ban Y, Taniyama M, Katagiri T (2000) Vitamin D receptor initiation codon polymorphism in Japanese patients with Graves’ disease. Thyroid 10(5):375–380CrossRefPubMed
3.
Ban Y, Taniyama M, Ban Y (2000) Vitamin D receptor gene polymorphism is associated with Graves’ disease in the Japanese population. J Clin Endocrinol Metab 85(12):639–4643
4.
Baqui AH, Black RE, Arifeen SE, Hill K, Mitra SN, al Sabir A (1998) Causes of childhood deaths in Bangladesh: results of a nationwide verbal autopsy study. Bull World Health Organ 76(2):161PubMedCentralPubMed
5.
Bellamy R, Ruwende C, Corrah T, McAdam KPWJ, Thursz M, Whittle HC, Hill AVS (1999) Tuberculosis and chronic hepatitis B virus infection in Africans and variation in the vitamin D receptor gene. J Infect Dis 179(3):721–724CrossRefPubMed
6.
Boussekey N, Leroy O, Alfandari S, Devos P, Georges H, Guery B (2006) Procalcitonin kinetics in the prognosis of severe community-acquired pneumonia. Intensive Care Med 32(3):469–472CrossRefPubMed
7.
Boussekey N, Leroy O, Georges H, Devos P, d’Escrivan T, Guery B (2005) Diagnostic and prognostic values of admission procalcitonin levels in community-acquired pneumonia in an intensive care unit. Infection 33(4):257–263CrossRefPubMed
8.
Chang TJ, Lei HH, Yeh JI, Chiu KC, Lee KC, Chen MC, Chuang LM (2000) Vitamin D receptor gene polymorphisms influence susceptibility to type 1 diabetes mellitus in the Taiwanese population. Clin Endocrinol (Oxf) 52(5):575–580CrossRef
9.
Cherian T (2003) WHO standard radiological definitions. Proceedings from a WHO consultative forum on ARI. World Health Organization, Geneva
10.
Chiu KC, Chuang LM, Yoon C (2001) The vitamin D receptor polymorphism in the translation initiation codon is a risk factor for insulin resistance in glucose tolerant Caucasians. BMC Med Genet 2(1):2CrossRefPubMedCentralPubMed
11.
D’Ambrosio D, Cippitelli M, Cocciolo MG, Mazzeo D, Di Lucia P, Lang R, Sinigaglia F, Panina-Bordignon P (1998) Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB down regulation in transcriptional repression of the p40 gene. J Clin Investig 101(1):252CrossRefPubMedCentralPubMed
12.
Gasser CS, Simonsen CC, Schilling JW, Schimke RT (1982) Expression of abbreviated mouse dihydrofolate reductase genes in cultured hamster cells. Proc Natl Acad Sci U S A 79(21):6522CrossRefPubMedCentralPubMed
13.
Gigane A, Torcianti M, Boldrini E, Manzotti S, Falcone G, Greco F, Mattioli-Belmonte M (2008) Vitamin K and D association stimulates in vitro osteoblast differentiation of fracture site derived human mesenchymal stem cells. J Biol Regul Homeost Agents 22(1):35–44
14.
Goldstein B, Giroir B, Randolph A, International Consensus Conference on Pediatric Sepsis (2005) International Pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med 6(1):2–8CrossRefPubMed
15.
Gombart AF, Borregaard N, Koeffler HP (2005) Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. FASEB J 19(9):1067–1077CrossRefPubMed
16.
Gruss P, Lai CJ, Dhar R, Khoury G (1979) Splicing as a requirement for biogenesis of functional 16S mRNA of simian virus 40. Proc Natl Acad Sci U S A 76(9):4317–4321CrossRefPubMedCentralPubMed
17.
Hamer DH, Leder P, Hamer DH, Leder P, Hamer DH, Leder P (1979) Splicing and the formation of stable RNA. Cell 18(4):1299–1302CrossRefPubMed
18.
Hamer DH, Smith KD, Boyer SH, Leder P (1979) SV40 recombinants carrying rabbit β-globin gene coding sequences. Cell 17(3):725–735CrossRefPubMed
19.
Harbarth S, Holeckova K, Froidevaux C, Pittet D, Ricou B, Grau GE, Vadas L, Pugin J (2001) Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis. Am J Respir Crit Care Med 64(3):396–402CrossRef
20.
Janssen R, Bont L, Siezen CLE, Hodemaekers HM, Ermers MJ, Doornbos G, Slot RV, Wijmenga C, Goeman JJ, Kimpen JLL, Houwelingen HSV, Kimman TG, Hoebee B (2007) Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. J Infect Dis 196(6):826–834CrossRefPubMed
21.
Krieg EF, Butler MA, Chang MH, Liu T, Yesupriya A, Dowling N, Lindegren ML (2010) Lead and cognitive function in VDR genotypes in the third National Health and Nutrition Examination Survey. Neurotoxicol Terato 32(2):262–272CrossRef
22.
23.
Lemire JM, Archer DC, Beck L, Spiegelberg HL (1995) Immunosuppressive actions of 1,25-dihydroxyvitamin D3: preferential inhibition of Th1 functions. J Nutr 125(6Supp):1704S–1708SPubMed
24.
Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G (2003) 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med 29(4):530–538CrossRefPubMed
25.
Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, Zügel U, Gallo RL, Eisenberg D, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL (2006) Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311(5768):1770–1773CrossRefPubMed
26.
Liu W, Zhang CY, Wu XM, Tian L, Li CZ, Zhao QM, Zhang PH, Yang SM, Yang H, Zhang XT, Cao WC (2003) A case-control study on the vitamin D receptor gene polymorphisms and susceptibility to pulmonary tuberculosis. Zhonghua Liu Xing Bing Xue Za Zhi 24(5):389–392PubMed
27.
Lu Q, Li CC (2013) Comment on children with community-acquired pneumonia. Chin J Pediatr 51(10):721–724
28.
Markowitz RI, Ruchelli E (1998) Pneumonia in infants and children: radiological pathological correlation. Semin Roentgenol 33(2):151–162CrossRefPubMed
29.
Matheu V, Bäck O, Mondoc E, Issazadeh-Navikas S (2003) Dual effects of vitamin D-induced alteration of TH1/TH2 cytokine expression: enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease. J Allergy Clin Immuno 112(3):585–592CrossRef
30.
McDermott MF, Ramachandran A, Ogunkolade BW, Aganna E, Curtis D, Boucher BJ, Snehalatha C, Hitman GA (1997) Allelic variation in the vitamin D receptor influences susceptibility to IDDM in Indian Asians. Diabetologia 40(8):971–975CrossRefPubMed
31.
Meisner M, Rotgeri A, Brunkhorst FM (2000) A semi-quantitative point-of-care test for the measurement of procalcitonin. J Lab Med 24:76–85
32.
Müller B, Becker KL, Schächinger H, Rickenbacher PR, Huber PR, Zimmerli W, Ritz R (2000) Calcitonin precursors are reliable markers of sepsis in a medical intensive care unit. Crit Care Med 28((4):977–983CrossRefPubMed
33.
Nyström PO (1998) The systemic inflammatory response syndrome: definitions and aetiology. J Antimicrob Chemother 41(suppl 1):1–7CrossRefPubMed
34.
Pichler J, Gerstmayr M, Szépfalusi Z, Urbanek R, Peterlik M, Willheim M (2002) 1 alpha,25(OH)2D3 inhibits not only Th1 but also Th2 differentiation in human cord blood T cells. Pediatr Res 52(1):12–18PubMed
35.
Poon AH, Laprise C, Lemire M, Montpetit A, Sinnett D, Schurr E, Hudson TJ (2004) Association of vitamin D receptor genetic variants with susceptibility to asthma and atopy. Am J Respir Crit Care Med 170(9):967–973CrossRefPubMed
36.
Raby BA, Lazarus R, Silverman EK, Lake S, Lange C, Wjst M, Weiss ST (2004) Association of vitamin D receptor gene polymorphisms with childhood and adult asthma. Am J Respir Crit Care Med 170(10):1057–1065CrossRefPubMed
37.
Reichel H, Koeffler HP, Tobler A, Norman AW (1987) 1 alpha,25-Dihydroxyvitamin D3 inhibits gamma-interferon synthesis by normal human peripheral blood lymphocytes. Proc Natl Acad Sci U S A 84(10):3385–3389CrossRefPubMedCentralPubMed
38.
Ren XX, Song GW (2006) Pediatric risk of mortality III score and pediatric critical illness score. J Appl Clin Pediatr 21(6):382–384
39.
Ren XX, Song GW, Liao B, Chen SX (2003) Pediatric critical illness score and systemic inflammatory response syndrome in assessing the severity and prognosis of pediatric patients. J Appl Clin Pediatr 18(2):105–107
40.
Roth DE, Jones AB, Prosser C, Robinson JL, Vohra S (2008) Vitamin D receptor polymorphisms and the risk of acute lower respiratory tract infection in early childhood. J Infect Dis 197(5):676–680CrossRefPubMed
41.
Roy S, Frodsham A, Saha B, Hazra SK, Mascie-Taylor CGN, Hill AVS (1999) Association of vitamin D receptor genotype with leprosy type. J Infect Dis 179(1):187–191CrossRefPubMed
42.
Rudan I, Boschi-Pinto C, Biloglav Z, Mulholland K, Campbell H (2008) Epidemiology and etiology of childhood pneumonia. Bull World Health Organ 86(5):408–416BCrossRefPubMedCentralPubMed
43.
Sandra Tjabringa G, Rabe KF, Hiemstra PS (2005) The human cathelicidin LL-37: a multifunctional peptide involved in infection and inflammation in the lung. Pulm Pharmacol Ther 18:321–327CrossRefPubMed
44.
Selvaraj P, Narayanan PR, Reetha AM (2000) Association of vitamin D receptor genotypes with the susceptibility to pulmonary tuberculosis in female patients & resistance in female contacts. Indian J Med Res 111:172–179PubMed
45.
Selwyn BJ et al (1990) The epidemiology of acute respiratory tract infection in young children: comparison of findings from several developing countries. Clin Infect Dis 12:S870–S888CrossRef
46.
Sørensen OE, Follin P, Johnsen AH, Calafat J, Tjabringa GS, Hiemstra PS, Borregaard N et al (2001) Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3. Blood 97:3951–3959CrossRefPubMed
47.
Tang J, Zhou R, Luger D, Zhu W, Silver PB, Grajewski RS, Su SB, Chan CC, Adorini L, Caspi RR (2009) Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response. J Immunol 182(8):4624–4632CrossRefPubMedCentralPubMed
48.
The Group of Emergency, Chinese pediatric Society, and Chinese Medical Association (2006) Pediatric septic shock (septic shock) treatment recommended program. China Pediatr Emerg Med 13(4):313–315
49.
The Subspecialty Group of Respiratory Diseases, The Editorial Board, Chinese Journal of Pediatrics (2007) Guidelines for management of children community acquired pneumonia. Chin J Pediatr 45(3):223–226
50.
Wang TT, Tavera-Mendoza LE, Laperriere D, Libby E, Burton MacLeod N, Nagai Y, Bourdeau V, Lallemant B, Zhang R, Mader S, White JH (2005) Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol 19(11):2685–2695CrossRefPubMed
51.
Wilkinson RJ, Llewelyn M, Toossi Z, Patel P, Pasvol G, Lalvani A, Wright D, Latif M, Davidson RN (2000) Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: a case-control study. Lancet 355(9204):618–621CrossRefPubMed
52.
World Health Organization (1995) The management of acute respiratory infections in children. Practical guidelines for outpatient care. World Health Organization, Geneva
53.
World Health Organization (2001) Standardization of interpretation of chest radiographs for the diagnosis of pneumonia in children. In WHO/V&B/01.35. Pneumonia Vaccine Trials Investigator’s Group. World Health Organization, Geneva
Metadaten
Titel
Polymorphism rs2239185 in vitamin D receptor gene is associated with severe community-acquired pneumonia of children in Chinese Han population: a case-control study
verfasst von
Wei Li
Linying Guo
Hongri Li
Chunrong Sun
Xiaodai Cui
Guowei Song
Jianhua Wang
Qi Zhang
Publikationsdatum
01.05.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Pediatrics / Ausgabe 5/2015
Print ISSN: 0340-6199
Elektronische ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-014-2433-0

Weitere Artikel der Ausgabe 5/2015

European Journal of Pediatrics 5/2015 Zur Ausgabe

Case Report

Stickler syndrome associated with epilepsy: report of three cases

Original Article

Dutch paediatrician’s opinions about acute care for critically ill children in general hospitals

Original Article

Relationship between elevated triglyceride levels with the increase of HOMA-IR and HOMA-β in healthy children and adolescents with normal weight

Review

Vitamin D in childhood and adolescence: an expert position statement

Short Communication

A note of caution on the diagnosis of Martin-Probst syndrome by the detection of the p.D59G mutation in the RAB40AL gene

Correspondence

Transport of infants with congenital heart disease

Neu im Fachgebiet Pädiatrie

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

17.05.2024 Klinik aktuell Nachrichten

Sie sei „ethisch geboten“, meint Gesundheitsminister Karl Lauterbach: mehr Transparenz über die Qualität von Klinikbehandlungen. Um sie abzubilden, lässt er gegen den Widerstand vieler Länder einen virtuellen Klinik-Atlas freischalten.

ADHS-Medikation erhöht das kardiovaskuläre Risiko

16.05.2024 Herzinsuffizienz Nachrichten

Erwachsene, die Medikamente gegen das Aufmerksamkeitsdefizit-Hyperaktivitätssyndrom einnehmen, laufen offenbar erhöhte Gefahr, an Herzschwäche zu erkranken oder einen Schlaganfall zu erleiden. Es scheint eine Dosis-Wirkungs-Beziehung zu bestehen.

Erstmanifestation eines Diabetes-Typ-1 bei Kindern: Ein Notfall!

16.05.2024 DDG-Jahrestagung 2024 Kongressbericht

Manifestiert sich ein Typ-1-Diabetes bei Kindern, ist das ein Notfall – ebenso wie eine diabetische Ketoazidose. Die Grundsäulen der Therapie bestehen aus Rehydratation, Insulin und Kaliumgabe. Insulin ist das Medikament der Wahl zur Behandlung der Ketoazidose.

Frühe Hypertonie erhöht späteres kardiovaskuläres Risiko

16.05.2024 Arterielle Hypertonie in der Pädiatrie Nachrichten

Wie wichtig es ist, pädiatrische Patienten auf Bluthochdruck zu screenen, zeigt eine kanadische Studie: Hypertone Druckwerte in Kindheit und Jugend steigern das Risiko für spätere kardiovaskuläre Komplikationen.

Update Pädiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise