Skip to main content
Erschienen in: Supportive Care in Cancer 1/2015

01.01.2015 | Original Article

End-of-life characteristics and palliative care provision for elderly patients suffering from acute myeloid leukemia

verfasst von: Hon-Wai Benjamin Cheng, Cho-Wing Li, Kwok-Ying Chan, Ho-Yan Au, Pan-Fong Chan, Yim-Ching Sin, Yan Szeto, Mau-Kwong Sham

Erschienen in: Supportive Care in Cancer | Ausgabe 1/2015

Einloggen, um Zugang zu erhalten

Abstract

Purpose

End-of-life care characteristics and palliative care (PC) utilization of elderly acute myeloid leukemia (AML) patients have rarely been reported. The aim of this study was to evaluate the cause of death, place of death and PC utilization of older adults (age 60 years or above) suffering from AML.

Methods

Patients were recruited retrospectively from two hematology units in Hong Kong, which consisted of one university department with Bone Marrow Transplant service, and one regional hospital with hematology specialty service. Collaboration with PC unit was established. Elderly AML patients referred to PC service were included. Medical records of all identified patients would be reviewed retrospectively by two PC physicians.

Results

From October 2011 to April 2013, 156 hematological cancer patients were referred for PC; 43 elderly AML patients were included into data analysis. The median time from AML diagnosis to death was 9.1 months. Up to 46.5 % patients received supportive care alone since diagnosis. More than half of elderly AML patients died in acute ward and hematology units (53.5 %), while 30.2 % died in PC settings. Overall, 51.2 % of patients spent the whole period of their final month of life in-hospital. Infection-related diagnoses contributed to 51.2 % of deaths. Median time from AML diagnosis to first PC consultation was 1.0 month. PC service includes psychosocial support (100 %), hospice in-patient care (30.2 %), homecare (60.5 %), PC outpatient clinic (14.0 %) and bereavement care (93.0 %).

Conclusions

Elderly AML patients carry dismal prognosis with their final phase of disease mostly hospitalized in acute care settings. Infections and bleeding could complicate course of illness and lead to rapid deterioration. PC collaboration remains important in psychosocial support and coverage of dying AML patients in non-hospice settings.
Literatur
1.
Zurück zum Zitat Klepin HD, Balducci L (2009) Acute myelogenous leukemia in older adults. Oncologist 14:222–232PubMedCrossRef Klepin HD, Balducci L (2009) Acute myelogenous leukemia in older adults. Oncologist 14:222–232PubMedCrossRef
2.
Zurück zum Zitat Estey E (2007) Acute myeloid leukemia and myelodysplastic syndromes in older patients. J Clin Oncol 25:1908–1915PubMedCrossRef Estey E (2007) Acute myeloid leukemia and myelodysplastic syndromes in older patients. J Clin Oncol 25:1908–1915PubMedCrossRef
3.
Zurück zum Zitat Pollyea DA, Kohrt HE, Medeiros BC (2011) Acute myeloid leukaemia in the elderly: a review. Br J Haematol 152:524–542PubMedCrossRef Pollyea DA, Kohrt HE, Medeiros BC (2011) Acute myeloid leukaemia in the elderly: a review. Br J Haematol 152:524–542PubMedCrossRef
4.
Zurück zum Zitat Manitta VJ, Philip JA, Cole-Sinclair MF (2010) Palliative care and the hemato-oncological patient: can we live together? a review of the literature. J Palliat Med 13(8):1021–1025PubMedCrossRef Manitta VJ, Philip JA, Cole-Sinclair MF (2010) Palliative care and the hemato-oncological patient: can we live together? a review of the literature. J Palliat Med 13(8):1021–1025PubMedCrossRef
5.
Zurück zum Zitat Corbett CL, Johnstone M, Trauer JM, Spruyt O (2013) Palliative care and hematological malignancies: increased referrals at a comprehensive cancer centre. J Palliat Med 16(5):537–541PubMedCrossRef Corbett CL, Johnstone M, Trauer JM, Spruyt O (2013) Palliative care and hematological malignancies: increased referrals at a comprehensive cancer centre. J Palliat Med 16(5):537–541PubMedCrossRef
6.
Zurück zum Zitat Bauder F, Capdupuy C, Renoux M (2000) Characteristics of deaths in a department of oncohaematology from a general hospital: a study of 81 cases. Support Care Cancer 8(4):302–306CrossRef Bauder F, Capdupuy C, Renoux M (2000) Characteristics of deaths in a department of oncohaematology from a general hospital: a study of 81 cases. Support Care Cancer 8(4):302–306CrossRef
7.
Zurück zum Zitat Cheng BHW, Sham MMK, Chan KY, Li CW, Au HY (2013) Intensive palliative care for patients with hematological cancer dying in hospice: analysis of the level of medical care in the final week of life. Am J Hosp Palliat Care Cheng BHW, Sham MMK, Chan KY, Li CW, Au HY (2013) Intensive palliative care for patients with hematological cancer dying in hospice: analysis of the level of medical care in the final week of life. Am J Hosp Palliat Care
8.
9.
Zurück zum Zitat O'Donnell MR, Abboud CN, Altman J et al (2012) Acute myeloid leukemia. J Natl Compr Cancer Netw 10(8):984–1021 O'Donnell MR, Abboud CN, Altman J et al (2012) Acute myeloid leukemia. J Natl Compr Cancer Netw 10(8):984–1021
10.
Zurück zum Zitat Tilly H, Castaigne S, Bordessoule D et al (1990) Low dose cytarabine versus intensive chemotherapy in the treatment of acute nonlymphocytic leukemia in the elderly. J Clin Oncol 8:272–279PubMed Tilly H, Castaigne S, Bordessoule D et al (1990) Low dose cytarabine versus intensive chemotherapy in the treatment of acute nonlymphocytic leukemia in the elderly. J Clin Oncol 8:272–279PubMed
11.
Zurück zum Zitat Nosari A, Barberis M, Landonio G et al (1991) Infections in haematologic neoplasms: autopsy findings. Haematologica 76(2):135–140PubMed Nosari A, Barberis M, Landonio G et al (1991) Infections in haematologic neoplasms: autopsy findings. Haematologica 76(2):135–140PubMed
12.
Zurück zum Zitat White PH, Kuhlenschmidt HL, Vancura BG, Navari RM (2003) Antimicrobial use in patients with advanced cancer receiving hospice care. J Pain Symptom Manag 25(5):438–443CrossRef White PH, Kuhlenschmidt HL, Vancura BG, Navari RM (2003) Antimicrobial use in patients with advanced cancer receiving hospice care. J Pain Symptom Manag 25(5):438–443CrossRef
13.
Zurück zum Zitat Benjamin Cheng HW, Sham MK, Chan KY (2014) Emergence of vancomycin-resistant enterococci in the palliative care setting—how to strike the right balance in infection control measures? J Pain Symptom Manag 47(1):e7–e8CrossRef Benjamin Cheng HW, Sham MK, Chan KY (2014) Emergence of vancomycin-resistant enterococci in the palliative care setting—how to strike the right balance in infection control measures? J Pain Symptom Manag 47(1):e7–e8CrossRef
14.
Zurück zum Zitat Maddocks I, Bentley L, Sheedy J (1994) Quality of life in patients dying from haematological diseases. Ann Acad Med 23:244–248 Maddocks I, Bentley L, Sheedy J (1994) Quality of life in patients dying from haematological diseases. Ann Acad Med 23:244–248
15.
Zurück zum Zitat McGrath P, Holewa H (2007) Special considerations for haematology patients in relation to end-of-life care: Australian findings. Eur J Cancer Care 16(2):164–171CrossRef McGrath P, Holewa H (2007) Special considerations for haematology patients in relation to end-of-life care: Australian findings. Eur J Cancer Care 16(2):164–171CrossRef
16.
Zurück zum Zitat Rodin G, Yuen D, Mischitelle A et al (2013) Traumatic stress in acute leukemia. Psychooncology 22(2):299–307PubMed Rodin G, Yuen D, Mischitelle A et al (2013) Traumatic stress in acute leukemia. Psychooncology 22(2):299–307PubMed
17.
Zurück zum Zitat Sekeres MA, Stone RM, Zahrieh D et al (2004) Decision making and quality of life in older adults with AML or advanced MDS. Leukemia 18:809–816PubMedCrossRef Sekeres MA, Stone RM, Zahrieh D et al (2004) Decision making and quality of life in older adults with AML or advanced MDS. Leukemia 18:809–816PubMedCrossRef
18.
Zurück zum Zitat Quill TE, Abernethy AP (2013) Generalist plus specialist palliative care—creating a more sustainable model. N Engl J Med 368(13):1173–1175PubMedCrossRef Quill TE, Abernethy AP (2013) Generalist plus specialist palliative care—creating a more sustainable model. N Engl J Med 368(13):1173–1175PubMedCrossRef
19.
Zurück zum Zitat Temel JS, Greer JA, Muzikansky A et al (2010) Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med 363:733–742PubMedCrossRef Temel JS, Greer JA, Muzikansky A et al (2010) Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med 363:733–742PubMedCrossRef
20.
Zurück zum Zitat Zimmermann C, Yuen D, Mischitelle A et al (2013) Symptom burden and supportive care in patients with acute leukemia. Leuk Res 37(7):731–736PubMedCrossRef Zimmermann C, Yuen D, Mischitelle A et al (2013) Symptom burden and supportive care in patients with acute leukemia. Leuk Res 37(7):731–736PubMedCrossRef
21.
Zurück zum Zitat Cheng HW, Li CW, Chan KY et al (2014) Bringing palliative care into geriatrics in a Chinese culture society—results of a collaborative model between palliative medicine and geriatrics unit in Hong Kong. J Am Geriatr Soc 62(4):779–781PubMedCrossRef Cheng HW, Li CW, Chan KY et al (2014) Bringing palliative care into geriatrics in a Chinese culture society—results of a collaborative model between palliative medicine and geriatrics unit in Hong Kong. J Am Geriatr Soc 62(4):779–781PubMedCrossRef
22.
Metadaten
Titel
End-of-life characteristics and palliative care provision for elderly patients suffering from acute myeloid leukemia
verfasst von
Hon-Wai Benjamin Cheng
Cho-Wing Li
Kwok-Ying Chan
Ho-Yan Au
Pan-Fong Chan
Yim-Ching Sin
Yan Szeto
Mau-Kwong Sham
Publikationsdatum
01.01.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Supportive Care in Cancer / Ausgabe 1/2015
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-014-2333-x

Weitere Artikel der Ausgabe 1/2015

Supportive Care in Cancer 1/2015 Zur Ausgabe

Bei seelischem Stress sind Checkpoint-Hemmer weniger wirksam

03.06.2024 NSCLC Nachrichten

Wie stark Menschen mit fortgeschrittenem NSCLC von einer Therapie mit Immun-Checkpoint-Hemmern profitieren, hängt offenbar auch davon ab, wie sehr die Diagnose ihre psychische Verfassung erschüttert

Antikörper mobilisiert Neutrophile gegen Krebs

03.06.2024 Onkologische Immuntherapie Nachrichten

Ein bispezifischer Antikörper formiert gezielt eine Armee neutrophiler Granulozyten gegen Krebszellen. An den Antikörper gekoppeltes TNF-alpha soll die Zellen zudem tief in solide Tumoren hineinführen.

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

29.05.2024 Larynxkarzinom Nachrichten

Fast ein Viertel der Personen mit mäßig dysplastischen Stimmlippenläsionen entwickelt einen Kehlkopftumor. Solche Personen benötigen daher eine besonders enge ärztliche Überwachung.

15% bedauern gewählte Blasenkrebs-Therapie

29.05.2024 Urothelkarzinom Nachrichten

Ob Patienten und Patientinnen mit neu diagnostiziertem Blasenkrebs ein Jahr später Bedauern über die Therapieentscheidung empfinden, wird einer Studie aus England zufolge von der Radikalität und dem Erfolg des Eingriffs beeinflusst.

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.