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15.03.2018 | Original Article

Prediction of chemotherapy-induced nausea and vomiting from patient-reported and genetic risk factors

verfasst von: Sonam Puri, Kelly A. Hyland, Kristine Crowe Weiss, Gillian C. Bell, Jhanelle E. Gray, Richard Kim, Hui-Yi Lin, Aasha I. Hoogland, Brian D. Gonzalez, Ashley M. Nelson, Anita Y. Kinney, Stacy M. Fischer, Daneng Li, Paul B. Jacobsen, Howard L. McLeod, Heather S. L. Jim

Erschienen in: Supportive Care in Cancer | Ausgabe 8/2018

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Abstract

Purpose

Chemotherapy-induced nausea and vomiting (CINV) is common among cancer patients. Early identification of patients at risk for CINV may help to personalize anti-emetic therapies. To date, few studies have examined the combined contributions of patient-reported and genetic risk factors to CINV. The goal of this study was to evaluate these risk factors.

Methods

Prior to their first chemotherapy infusion, participants completed demographic and risk factor questionnaires and provided a blood sample to measure genetic variants in ABCB1 (rs1045642) and HTR3B (rs45460698) as well as CYP2D6 activity score. The M.D. Anderson Symptom Inventory was completed at 24 h and 5-day post-infusion to assess the severity of acute and delayed CINV, respectively.

Results

Participants were 88 patients (55% female, M = 60 years). A total of 23% experienced acute nausea and 55% delayed nausea. Younger age, history of pregnancy-related nausea, fewer hours slept the night prior to infusion, and variation in ABCB1 were associated with more severe acute nausea; advanced-stage cancer and receipt of highly emetogenic chemotherapy were associated with more severe delayed nausea (p values < 0.05). In multivariable analyses, ABCB1 added an additional 5% predictive value beyond the 13% variance explained by patient-reported risk factors.

Conclusions

The current study identified patient-reported and genetic factors that may place patients at risk for acute nausea despite receipt of guideline-consistent anti-emetic prophylaxis. Additional studies examining other genetic variants are needed, as well as the development of risk prediction models including both patient-reported and genetic risk factors.

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Titel: Prediction of chemotherapy-induced nausea and vomiting from patient-reported and genetic risk factors
verfasst von: Sonam Puri
Kelly A. Hyland
Kristine Crowe Weiss
Gillian C. Bell
Jhanelle E. Gray
Richard Kim
Hui-Yi Lin
Aasha I. Hoogland
Brian D. Gonzalez
Ashley M. Nelson
Anita Y. Kinney
Stacy M. Fischer
Daneng Li
Paul B. Jacobsen
Howard L. McLeod
Heather S. L. Jim
Publikationsdatum: 15.03.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 8/2018
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-018-4120-6

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Prediction of chemotherapy-induced nausea and vomiting from patient-reported and genetic risk factors