Conducting studies on complications and frequencies of secondary surgeries can be problematic from two aspects: the need for sufficiently large materials to detect rare events and to get reliable data. To obtain sufficient volumes of data, national registers can be used. However, in the Swespine, registration of cervical spine procedures was not started until 2006 and data were not initially reported from all settings performing cervical spine surgery. Furthermore, the long-term follow-up rates in registers tend not to be satisfactory and may lead to problems with too large numbers of loss of patients. In a study by Aghayev et al., 5-year follow-up of ADR in the SwissSpine register was only 64.8% [
18]. The retrospective study design is not suitable for research questions requiring baseline data, but may have an advantage for long-term follow-up studies of complications. The follow-up rates of 94% in this study are higher and with more reliable data than we could get from the Swespine register. Previous studies comparing advert events and secondary surgeries between ACDF and ADR have during the last decade been presented in randomized trials and meta-analyzes with most articles reporting fewer secondary interventions in the ADR groups. The randomized controlled trials are predominantly industry sponsored investigational device exemption (IDE) studies with the intention to get FDA approval for the device in the US. Randomized trials with the primary intention to compare outcome between two different treatments may not be the best study design to evaluate rare events as reoperations. Sponsorship also might lead to a bias in decision making in secondary interventions [
19‐
22]. Common reasons for secondary surgeries after ACDF in most randomized trials are pseudarthrosis and ASD. In this study, ASD was also the most common reason for a new intervention in the ACDF group, while intervention for pseudarthrosis was less than 1% which is lower than found in another retrospective study of 672 patients [
23], but consistent with other publications [
24,
25]. A majority of patients in this cohort were treated with iliac crest bone and plating which might create better conditions for healing than alternative methods [
26‐
28]. It should also be pointed out that pseudarthrosis could be a difficult diagnosis to establish as there is no sufficiently accurate radiological method to ensure very small movements in non-healed segments [
29,
30]. Patients in this cohort who were reoperated because of pseudarthrosis were diagnosed with CT after a combination of suspected non-healing on plain x-rays and continuous pain reported by the patient. The possibility that patients without severe symptoms, and thus not examined with CT, may have had a non-healed fusion can, therefore, not be ruled out. Despite a quite large number of patients operated with iliac crest bone in this cohort, no patient was reoperated due to complications at donor site. Reoperation rate because of ASD in this study was 5% in the ACDF group with a follow-up time varying from 0 to 15 years. This is lower than reported in other literature. In a retrospective study by Lee et al., 1038 patients were analyzed regarding reoperation because of ASD and they found a relatively constant rate of 2.4%/year and that smoking and female gender increased the risk and that more than two surgical levels decreased the risk for reoperation because of ASD [
31]. In the present study, complete data for smoking were not available, why the impact of smoking could not be analyzed. Another study comparing reoperations for ASD in a cohort of patients outside RCTs with reoperation rates of patients inside the RCTs, and found a lower rate of 2.1% within 2 years [
10]. Rates of reoperations because of ASD in this study were not statistically different between ACDF and ADR groups (
p = 0.40), consistent with a meta-analysis showing no significant statistical difference between groups [
32]. Ten patients in the ACDF group were reoperated because of the remaining neural compression and in most patients because of posterior pathology in the facet joints. This may reflect that patients in the ACDF group had more advanced degenerative changes than the patients in the ADR group, in which no patient was reoperated because of the same reason. Reoperation because of infection could be established in one patient who was treated with an ACDF. The anterior approach for cervical spine surgery is known for low infection rates and infection is seldom a reason for readmission [
33]. The cohort in this study was followed for at least 5 years with a follow-up of 94% and showed a statistically significant difference in rates of reoperations in total, advantageous for ACDF. This finding is deviant to results from most previously published RCTs and meta-analyzes showing lower rates of reoperations in the ADR groups [
34‐
38]. The results in our study are supported by a study presented by Nandyala et al. in 2014. They used a nationwide inpatient sample database in the US with data from more than 180,000 patients, found revision rates for ACDF and ADR of 2.0 and 7.7%, respectively, for one- and two-level surgeries during the years 2002–2011. They also found that revision surgery of ADR was associated with higher incidence of postoperative infection and greater length of stay [
11]. The majority of patients in the ADR group in the present study were reoperated because of implant migration and/or instability, which is consistent with the results from a previous biomechanical in vivo CT study [
39]. It must be pointed out that biomechanical characteristics may vary between different brands and designs of ADRs, and thus, the data in this study are not completely generalizable [
40]. We cannot with this study point out certain risk factors for reoperation after treatment with ADR, event though we found that women were overrepresented in the group of patients who had undergone a second intervention in the ADR group. This might be a finding that could be associated with gender differences in bone morphology, but needs to be investigated further [
41]. Evaluation of bone mineral density was not performed routinely in this cohort, and therefore, no analysis of association to reoperation rate could be done. There are several limitations with a retrospective study comparing different cohorts of patients as they might differ substantially in demographics and baseline data. There is also a risk for skewness between the groups depending on inclusion bias. As we in this study focused on reoperation following different surgical techniques, no conclusions can be made regarding patient reported outcomes. It can be argued that reoperation is not a good outcome measure and that decision making for this intervention may vary considerably between different surgeons. On the other hand, it is a dichotomous variable, also preceded by new symptoms and radiological findings that could not be neglected. Secondary surgical cervical spine interventions are associated with higher risk for complications, e.g., dysphagia, infection, and neurological damage, and must as far as possible be avoided.