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Archives of Virology

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03.11.2018 | Brief Report

Baicalein and baicalin as Zika virus inhibitors

verfasst von: Adrian Oo, Boon Teong Teoh, Sing Sin Sam, Sazaly Abu Bakar, Keivan Zandi

Erschienen in: Archives of Virology | Ausgabe 2/2019

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Abstract

At present, there is no effective antiviral agent for Zika virus (ZIKV), an arbovirus that is known for its teratogenic effects on newborns. Baicalein and baicalin were found to be capable of downregulating ZIKV replication up to 10 hours postinfection, while prophylactic effects were evident in pre-treated cells. Baicalein exhibited its highest potency during intracellular ZIKV replication, whereas baicalin was most effective against virus entry. Our in silico interaction assays predicted that both compounds exhibited the strongest binding affinities towards ZIKV NS5, while the virus envelope glycoprotein was the least likely target protein. These findings serve as a crucial platform for further in-depth studies to decipher the underlying anti-ZIKV mechanism(s) of each compound.

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Titel: Baicalein and baicalin as Zika virus inhibitors
verfasst von: Adrian Oo
Boon Teong Teoh
Sing Sin Sam
Sazaly Abu Bakar
Keivan Zandi
Publikationsdatum: 03.11.2018
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 2/2019
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-018-4083-4

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