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Erschienen in:

29.09.2016 | Original Article

Serum levels of 25-hydroxyvitamin D are associated with periodontal disease

verfasst von: Markus Laky, Kristina Bertl, Hady Haririan, Oleh Andrukhov, Rudolf Seemann, Ivo Volf, Alice Assinger, Reinhard Gruber, Andreas Moritz, Xiaohui Rausch-Fan

Erschienen in: Clinical Oral Investigations | Ausgabe 5/2017

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Abstract

Objectives

Vitamin D plays an essential role in bone metabolism as well as in immunity. Hence, it might affect the development and extent of periodontal disease. The aim of this study was the assessment of 25-hydroxyvitamin D (25(OH)D) status in periodontal disease.

Materials and methods

Twenty-nine patients with severe periodontal disease and 29 healthy volunteers were recruited in this case-control-study. Serum 25(OH)D levels, Periodontal Probing Depth (PPD), Clinical Attachment Level (CAL), Bleeding on Probing (BOP), Body Mass Index (BMI), and current smoking status and smoking history (packyears) were assessed in all participants. Serum 25(OH)D levels were compared between controls and cases. Multivariable logistic regression was used to determine the odds ratio (OR) and 95 % confidence interval (CI) for periodontal disease in 25(OH)D deficient probands.

Results

Patients with periodontal disease presented a significantly higher proportion of deficient 25(OH)D levels (i.e., <50 nmol/l) compared to healthy controls (48 vs. 14 % respectively). The adjusted OR for periodontal disease with vitamin D deficiency was 1.5 (95 % CI, 1.13–1.98). No correlation between serum 25(OH)D levels and CAL, PPD, and BOP in the group with periodontal disease was found.

Conclusions

In this case-control-study 25(OH)D deficiency is significantly associated with periodontal disease.

Clinical relevance

The assessment of vitamin D levels in patients presenting with periodontal disease seems advisable, as vitamin D deficiency might be involved in the onset and progression of periodontal disease.

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Titel: Serum levels of 25-hydroxyvitamin D are associated with periodontal disease
verfasst von: Markus Laky
Kristina Bertl
Hady Haririan
Oleh Andrukhov
Rudolf Seemann
Ivo Volf
Alice Assinger
Reinhard Gruber
Andreas Moritz
Xiaohui Rausch-Fan
Publikationsdatum: 29.09.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 5/2017
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-016-1965-2

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Serum levels of 25-hydroxyvitamin D are associated with periodontal disease