Erschienen in:
01.07.2010 | Article
Changing etiology of community-acquired bacterial meningitis in adults: a nationwide multicenter study in Korea
verfasst von:
S.-Y. Moon, D. R. Chung, S.-W. Kim, H. H. Chang, H. Lee, D. S. Jung, Y.-S. Kim, S. I. Jung, S. Y. Ryu, S. T. Heo, C. Moon, H. K. Ki, J. S. Son, K. T. Kwon, S. Y. Shin, J. S. Lee, S. S. Lee, J.-Y. Rhee, J.-A. Lee, M. K. Joung, H. S. Cheong, K. R. Peck, J.-H. Song
Erschienen in:
European Journal of Clinical Microbiology & Infectious Diseases
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Ausgabe 7/2010
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Abstract
Epidemiologic data on the etiologic organisms is important for appropriate empirical antibiotic treatment of bacterial meningitis. We identified the etiologies of community-acquired bacterial meningitis in Korean adults and the associated epidemiological factors. A retrospective, multicenter nationwide study was carried out. Patients 18 years of age or older with community-acquired bacterial meningitis with a confirmed pathogen were enrolled. Demographic, clinical, and microbiological data were collected. One hundred and ninety-five cases were collected. Streptococcus pneumoniae was the most common pathogen (50.8%), followed by Staphylococcus aureus (10.3%), Klebsiella pneumoniae (7.7%), Listeria monocytogenes (6.7%), and group B Streptococcus (3.1%). The penicillin resistance rate of the S. pneumoniae was 60.3%; 40.0% of the organisms were not susceptible to third-generation cephalosporins. The combination of third-generation cephalosporin with vancomycin was used in 76.3% of cases. Steroids were given before or with the first dose of antibiotics in 37.4% of patients. The 30-day mortality rate was 20.5% and neurological sequelae developed in 15.6% of cases. S. pneumoniae was the most common organism identified in community-acquired bacterial meningitis among Korean adults. S. aureus, K. pneumoniae, L. monocytogenes, and group B Streptococcus were also common. S. pneumoniae had high rates of resistance to penicillin and third-generation cephalosporins.