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Journal of Infection and Chemotherapy
Erschienen in: Journal of Infection and Chemotherapy 2/2011

01.04.2011 | Review Article

Plasmid-mediated quinolone resistance: an update

verfasst von: José Manuel Rodríguez-Martínez, María Eliecer Cano, Carmen Velasco, Luis Martínez-Martínez, Álvaro Pascual

Erschienen in: Journal of Infection and Chemotherapy | Ausgabe 2/2011

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Abstract

In 1998, the first plasmid-mediated gene involved in quinolone resistance (currently named qnrA1) was reported. Extra qnr-like plasmid-mediated genes (qnrB, qnrS, qnrC, qnrD) and their chromosomal homologues have also been characterized. These genes code for a pentapeptide repeat protein that protects type II topoisomerases from quinolones. Since then, there have been reports of two other plasmid-mediated resistance mechanisms: the modification of quinolones with a piperazinyl substituent by the acetyltransferase, Aac(6′)-Ib-cr; and active efflux by QepA and OqxAB, pumps related to major facilitator superfamily (MFS) transporters. These genes have a wide geographic distribution (mainly in Enterobacteriaceae). Because of the difficulties of phenotypic detection of this type of resistance, its real prevalence is only partially known. One important point is that although these mechanisms cause only low-level resistance, they favor and complement the selection of other resistance mechanisms.
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Metadaten
Titel
Plasmid-mediated quinolone resistance: an update
verfasst von
José Manuel Rodríguez-Martínez
María Eliecer Cano
Carmen Velasco
Luis Martínez-Martínez
Álvaro Pascual
Publikationsdatum
01.04.2011
Verlag
Springer Japan
Erschienen in
Journal of Infection and Chemotherapy / Ausgabe 2/2011
Print ISSN: 1341-321X
Elektronische ISSN: 1437-7780
DOI
https://doi.org/10.1007/s10156-010-0120-2

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